Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP17L7 USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 JOSD2 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

1.97e-2611413222GO:0004843
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP17L7 USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 JOSD2 USP17L6P USP17L3 SENP6 USP17L22 USP17L15 USP17L8 USP17L13

4.06e-2613713223GO:0019783
GeneOntologyMolecularFunctiondeubiquitinase activity

USP17L7 USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 JOSD2 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

1.43e-2512413222GO:0101005
GeneOntologyMolecularFunctioncysteine-type peptidase activity

USP17L7 USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 CASP8 USP17L10 USP17L19 USP17L18 USP17L17 JOSD2 USP17L6P USP17L3 SENP6 USP17L22 USP17L15 USP17L8 USP17L13

4.99e-2419213224GO:0008234
GeneOntologyMolecularFunctionpeptidase activity

USP17L7 USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 CASP8 USP17L10 USP17L19 F12 USP17L18 USP17L17 JOSD2 RHBDL3 USP17L6P USP17L3 SENP6 USP17L22 USP17L15 USP17L8 USP17L13

1.41e-1365413226GO:0008233
GeneOntologyBiologicalProcessprotein modification by small protein removal

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 JOSD2 USP17L6P USP17L3 SENP6 USP17L22 USP17L15 USP17L8 USP17L13

1.93e-2414413122GO:0070646
GeneOntologyBiologicalProcessprotein deubiquitination

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 JOSD2 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.83e-2412513121GO:0016579
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

USP17L7 USP17L21 VPS18 USP17L4 USP17L2 USP17L12 USP17L1 TRIM58 USP17L20 USP17L11 USP17L24 USP17L5 FBXL15 USP17L10 USP17L19 USP17L18 USP17L17 JOSD2 USP17L6P USP17L3 SENP6 CTNNB1 USP17L22 USP17L15 USP17L8 RNF111 USP17L13

1.68e-10100913127GO:0070647
GeneOntologyBiologicalProcesspost-translational protein modification

USP17L7 USP17L21 VPS18 USP17L4 USP17L2 USP17L12 USP17L1 TRIM58 USP17L20 USP17L11 USP17L24 USP17L5 FBXL15 USP17L10 USP17L19 USP17L18 USP17L17 JOSD2 USP17L6P USP17L3 SENP6 CTNNB1 USP17L22 USP17L15 USP17L8 RNF111 USP17L13

6.67e-10107413127GO:0043687
GeneOntologyCellularComponentendoplasmic reticulum membrane

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 JPH1 USP17L17 USP17L6P USP17L3 USP17L22 ATP2A1 USP17L15 USP17L8 USP17L13

5.33e-05129313121GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 JPH1 USP17L17 USP17L6P USP17L3 USP17L22 ATP2A1 USP17L15 USP17L8 USP17L13

5.70e-05129913121GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 JPH1 USP17L17 USP17L6P USP17L3 USP17L22 ATP2A1 USP17L15 USP17L8 USP17L13

7.73e-05132713121GO:0042175
MousePhenoincreased trophectoderm apoptosis

USP17L2 USP17L15 USP17L13

1.51e-058923MP:0012119
DomainHABP4_PAI-RBP1

USP17L7 USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L13

4.53e-291613214PF04774
DomainHABP4_PAIRBP1-bd

USP17L7 USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L13

4.53e-291613214IPR006861
DomainUCH

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

1.32e-237113218PF00443
DomainUSP_2

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

1.32e-237113218PS00973
DomainUSP_3

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

1.75e-237213218PS50235
DomainUSP_dom

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

1.75e-237213218IPR028889
DomainPeptidase_C19_UCH

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

1.75e-237213218IPR001394
DomainUSP_CS

USP17L7 USP17L21 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

1.78e-226613217IPR018200
DomainUSP_1

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L3 USP17L22 USP17L8 USP17L13

5.44e-227013217PS00972
DomainARM-like

NCAPD3 DOHH APC2 TRRAP PPP4R3A AP4E1 TELO2 XPO6 EFR3B WDFY3 CTNNB1 GCN1

4.89e-0727013212IPR011989
Domain-

NCAPD3 DOHH APC2 TRRAP AP4E1 TELO2 XPO6 EFR3B WDFY3 CTNNB1 GCN1

5.13e-07222132111.25.10.10
DomainARM-type_fold

NCAPD3 DOHH APC2 TRRAP PPP4R3A AP4E1 TELO2 PIK3CB XPO6 EFR3B WDFY3 CTNNB1 GCN1

8.54e-0733913213IPR016024
DomainPH_dom-like

MYO10 DOK3 FRMPD1 ARHGEF18 FAM43B ARHGEF17 PPP4R3A MTMR11 AFAP1L2 RASA4 RASA4B WDFY3 ARAP1 FRMD3

1.98e-0642613214IPR011993
Domain-

MYO10 DOK3 ARHGEF18 FAM43B ARHGEF17 PPP4R3A AFAP1L2 RASA4 RASA4B ARAP1 FRMD3

1.06e-04391132112.30.29.30
Domain-

RASA4 RASA4B

1.48e-04313224.10.1130.10
DomainFacI_MAC

C7 AGRN

2.95e-0441322IPR003884
DomainFIMAC

C7 AGRN

2.95e-0441322SM00057
DomainMACPF_CS

C7 C9

7.30e-0461322IPR020863
DomainMACPF_2

C7 C9

1.02e-0371322PS51412
DomainMACPF_1

C7 C9

1.02e-0371322PS00279
DomainFYVE

ZFYVE9 ZFYVE26 WDFY3

1.10e-03291323PF01363
DomainFYVE

ZFYVE9 ZFYVE26 WDFY3

1.10e-03291323SM00064
DomainPH

MYO10 DOK3 ARHGEF18 AFAP1L2 RASA4 RASA4B ARAP1

1.23e-032291327PF00169
DomainBTK

RASA4 RASA4B

1.73e-0391322SM00107
DomainZnf_Btk_motif

RASA4 RASA4B

1.73e-0391322IPR001562
DomainBTK

RASA4 RASA4B

1.73e-0391322PF00779
DomainZF_BTK

RASA4 RASA4B

1.73e-0391322PS51113
DomainZnf_FYVE-rel

ZFYVE9 ZFYVE26 WDFY3

1.76e-03341323IPR017455
DomainMAC_perforin

C7 C9

2.15e-03101322IPR001862
DomainZnf_FYVE

ZFYVE9 ZFYVE26 WDFY3

2.43e-03381323IPR000306
DomainMACPF

C7 C9

2.62e-03111322PF01823
DomainZF_FYVE

ZFYVE9 ZFYVE26 WDFY3

2.82e-03401323PS50178
DomainARM

APC2 CTNNB1 GCN1

2.82e-03401323SM00185
DomainMACPF

C7 C9

3.12e-03121322IPR020864
DomainHTH_Psq

TIGD7 LCORL

3.12e-03121322IPR007889
DomainHTH_PSQ

TIGD7 LCORL

3.12e-03121322PS50960
DomainMACPF

C7 C9

3.12e-03121322SM00457
DomainPH

MYO10 DOK3 ARHGEF18 AFAP1L2 RASA4 RASA4B ARAP1

3.65e-032781327SM00233
DomainPH_DOMAIN

MYO10 DOK3 ARHGEF18 AFAP1L2 RASA4 RASA4B ARAP1

3.72e-032791327PS50003
DomainPH_domain

MYO10 DOK3 ARHGEF18 AFAP1L2 RASA4 RASA4B ARAP1

3.79e-032801327IPR001849
DomainFERM_M

MYO10 FRMPD1 FRMD3

4.20e-03461323PF00373
DomainRasGAP

RASA4 RASA4B

4.27e-03141322SM00323
DomainRasGAP_CS

RASA4 RASA4B

4.27e-03141322IPR023152
DomainArmadillo

APC2 CTNNB1 GCN1

4.46e-03471323IPR000225
DomainRasGAP

RASA4 RASA4B

4.90e-03151322PF00616
DomainRAS_GTPASE_ACTIV_1

RASA4 RASA4B

4.90e-03151322PS00509
DomainRAS_GTPASE_ACTIV_2

RASA4 RASA4B

4.90e-03151322PS50018
Domain-

MYO10 FRMPD1 FRMD3

5.02e-034913231.20.80.10
DomainFERM_central

MYO10 FRMPD1 FRMD3

5.02e-03491323IPR019748
DomainFERM_domain

MYO10 FRMPD1 FRMD3

5.02e-03491323IPR000299
DomainFERM/acyl-CoA-bd_prot_3-hlx

MYO10 FRMPD1 FRMD3

5.31e-03501323IPR014352
DomainFERM_1

MYO10 FRMPD1 FRMD3

5.31e-03501323PS00660
DomainFERM_2

MYO10 FRMPD1 FRMD3

5.31e-03501323PS00661
DomainFERM_3

MYO10 FRMPD1 FRMD3

5.31e-03501323PS50057
DomainBand_41_domain

MYO10 FRMPD1 FRMD3

5.31e-03501323IPR019749
DomainB41

MYO10 FRMPD1 FRMD3

5.31e-03501323SM00295
Domain-

TRRAP PIK3CB

5.58e-031613221.10.1070.11
DomainPI3Kc

TRRAP PIK3CB

5.58e-03161322SM00146
Domain-

RASA4 RASA4B

5.58e-031613221.10.506.10
DomainHEAT_type_2

DOHH GCN1

6.29e-03171322IPR021133
DomainPI3_PI4_kinase

TRRAP PIK3CB

7.04e-03181322PF00454
DomainPI3_4_KINASE_1

TRRAP PIK3CB

7.04e-03181322PS00915
DomainPI3_4_KINASE_2

TRRAP PIK3CB

7.04e-03181322PS00916
DomainPI3/4_kinase_cat_dom

TRRAP PIK3CB

7.04e-03181322IPR000403
DomainRasGAP_dom

RASA4 RASA4B

7.04e-03181322IPR001936
DomainPI3_4_KINASE_3

TRRAP PIK3CB

7.04e-03181322PS50290
PathwayREACTOME_RAS_PROCESSING

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.16e-30459619MM15671
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 TRRAP USP17L18 TOMM70 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

6.25e-201919621MM15289
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

USP17L7 USP17L21 ERBB2 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 PIK3CB RASA4 USP17L6P USP17L3 RASA4B USP17L22 USP17L15 VCL USP17L8 USP17L13

7.65e-193189624MM15278
PathwayREACTOME_DEUBIQUITINATION

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 TRRAP USP17L18 TOMM70 USP17L17 JOSD2 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.70e-182629622MM15286
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 TRRAP USP17L18 TOMM70 USP17L17 USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.56e-172219620M27578
PathwayREACTOME_DEUBIQUITINATION

USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 TRRAP USP17L18 TOMM70 USP17L17 JOSD2 USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

6.68e-162999621M27574
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

USP17L7 USP17L21 DOHH USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 NUP88 USP17L5 FBXL15 SEMA5A USP17L10 USP17L19 TRRAP USP17L18 TOMM70 USP17L17 JOSD2 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

1.22e-0613899626MM15307
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

USP17L21 DOHH USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 NUP88 USP17L5 FBXL15 SEMA5A USP17L10 USP17L19 TRRAP USP17L18 TOMM70 USP17L17 JOSD2 USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

1.22e-0514759625M19806
PathwayBIOCARTA_CELL2CELL_PATHWAY

BCAR1 CTNNB1 VCL

2.50e-059963MM1366
PathwayBIOCARTA_CELL2CELL_PATHWAY

BCAR1 CTNNB1 VCL

6.44e-0512963M12851
PathwayKEGG_ENDOMETRIAL_CANCER

ERBB2 APC2 PIK3CB CTNNB1

4.26e-0452964M19877
Pubmed

DUB-1, a deubiquitinating enzyme with growth-suppressing activity.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

1.00e-4421136198622927
Pubmed

DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

1.00e-44211361914583620
Pubmed

DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

1.00e-44211361911468161
Pubmed

The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

1.00e-4421136198756639
Pubmed

Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

1.00e-44211361912447969
Pubmed

DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

1.00e-44211361918980247
Pubmed

JAK2 is required for induction of the murine DUB-1 gene.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

7.33e-4422136199154835
Pubmed

Cytokine-regulated protein degradation by the ubiquitination system.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 JOSD2 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

1.20e-42351362116611142
Pubmed

DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.01e-4224136198995226
Pubmed

Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

8.35e-42251361921115691
Pubmed

Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

3.09e-41261361935816173
Pubmed

Cdc25A and Dub3 in a high-stakes balancing act.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

8.89e-41331362020228807
Pubmed

The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.15e-40341362020403174
Pubmed

DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.15e-40341362014699124
Pubmed

The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.15e-40341362015780755
Pubmed

USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.15e-40341362019188362
Pubmed

Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.15e-40341362011941478
Pubmed

Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.15e-40341362017109758
Pubmed

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.15e-40341362020388806
Pubmed

Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.15e-40341362020715989
Pubmed

Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.15e-4034136209806828
Pubmed

The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.15e-40341362020368735
Pubmed

The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.15e-40341362010936051
Pubmed

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.15e-40341362021448158
Pubmed

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

5.01e-40351362021239494
Pubmed

Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

9.32e-40291361932527007
Pubmed

The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

1.12e-39361362020147298
Pubmed

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.44e-39371362020228808
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 PRAMEF20 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

6.93e-36501362031806660
Pubmed

High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8

1.98e-1810136824207026
Pubmed

Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8

2.17e-1712136824695638
Pubmed

ES cell neural differentiation reveals a substantial number of novel ESTs.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8

1.31e-1614136811793228
Pubmed

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8

3.23e-1519136828067227
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 PRAMEF20 USP17L5 CASP8 USP17L10 USP17L19 USP17L18 USP17L17 NYNRIN USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.43e-146741362237196079
Pubmed

Human and mouse proteases: a comparative genomic approach.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8

1.12e-0981136812838346
Pubmed

A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L19 USP17L18 SAT1 USP17L17

2.42e-08119136828625976
Pubmed

DNA sequence and analysis of human chromosome 8.

USP17L7 USP17L4 USP17L1 JPH1 USP17L3 USP17L8

3.43e-0848136616421571
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

NCAPD3 ERBB2 HAUS5 MCM2 ADGRV1 MELK INTS5 TELO2 EFR3B NINL SENP6 HPS5 ARAP1

1.78e-075291361314621295
Pubmed

Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.

USP17L2 USP17L15 USP17L13

2.33e-074136322984479
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PALD1 ERBB2 MYO10 TOR4A TRRAP CABLES1 INTS5 GAREM2 XPO6 MCM3AP NINL ZFYVE26 WDFY3 GCN1 AGRN ARAP1 MVB12B

1.61e-0611051361735748872
Pubmed

Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation.

BCAR1 CTNNB1 VCL

6.88e-0610136311113628
Pubmed

CspA from Borrelia burgdorferi inhibits the terminal complement pathway.

C7 C9

1.52e-052136223943762
Pubmed

CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.

RASA4 RASA4B

1.52e-052136211448776
Pubmed

Fluoro-Chromogenic Labelling for Detection of MCM2 to Assess Proliferation Activity in HER2-amplified Breast Carcinomas.

ERBB2 MCM2

1.52e-052136230358612
Pubmed

Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin.

APC2 CTNNB1

1.52e-05213629823329
Pubmed

CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics.

BCAR1 VCL

1.52e-052136223974298
Pubmed

A novel protein-tyrosine phosphatase related to the homotypically adhering kappa and mu receptors.

PTPRU CTNNB1

1.52e-05213629054423
Pubmed

β-catenin and Her2/neu expression in rectal cancer: association with histomorphological response to neoadjuvant therapy and prognosis.

ERBB2 CTNNB1

1.52e-052136221538055
Pubmed

Necroptosis restricts influenza A virus as a stand-alone cell death mechanism.

CASP8 MLKL

1.52e-052136232797196
Pubmed

β-Catenin-dependent lysosomal targeting of internalized tumor necrosis factor-α suppresses caspase-8 activation in apoptosis-resistant colon cancer cells.

CASP8 CTNNB1

1.52e-052136223264463
Pubmed

Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility.

PTPRU CTNNB1

1.52e-052136224876153
Pubmed

Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin.

PTPRU CTNNB1

1.52e-052136212501215
Pubmed

p130Cas is an essential transducer element in ErbB2 transformation.

ERBB2 BCAR1

1.52e-052136220505116
Pubmed

MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection.

CASP8 MLKL

1.52e-052136236852999
Pubmed

Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells.

ERBB2 BCAR1

1.52e-052136223839042
Pubmed

HER2 and β-catenin protein location: importance in the prognosis of breast cancer patients and their correlation when breast cancer cells suffer stressful situations.

ERBB2 CTNNB1

1.52e-052136225636904
Pubmed

TRIM58 suppresses the tumor growth in gastric cancer by inactivation of β-catenin signaling via ubiquitination.

TRIM58 CTNNB1

1.52e-052136231747856
Pubmed

An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.

RASA4 RASA4B

1.52e-052136216041389
Pubmed

Deubiquitinating enzyme JOSD2 promotes hepatocellular carcinoma progression through interacting with and inhibiting CTNNB1 degradation.

JOSD2 CTNNB1

1.52e-052136235568970
Pubmed

β-Catenin haploinsufficiency promotes mammary tumorigenesis in an ErbB2-positive basal breast cancer model.

ERBB2 CTNNB1

1.52e-052136228096336
Pubmed

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.

APC2 TRRAP CTNNB1

2.57e-0515136316510875
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PALD1 MYO10 FRMPD1 ARHGEF17 TOMM70 STARD9 MCM3AP VPS13B ADGRL3

3.41e-05407136912693553
Pubmed

24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8.

CASP8 MLKL

4.54e-053136225697054
Pubmed

Tumor necrosis factor α stimulates Her-2 cleavage by activated caspase-8.

ERBB2 CASP8

4.54e-053136222922291
Pubmed

Caspase-8 modulates physiological and pathological angiogenesis during retina development.

CASP8 MLKL

4.54e-053136231454332
Pubmed

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis.

CASP8 MLKL

4.54e-053136233510145
Pubmed

CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.

RASA4 RASA4B

4.54e-053136225637021
Pubmed

Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion.

ERBB2 BCAR1

4.54e-053136228442738
Pubmed

HER2 activation results in β-catenin-dependent changes in pulmonary epithelial permeability.

ERBB2 CTNNB1

4.54e-053136225326580
Pubmed

Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering β-catenin signalling and GADD45G expression.

PAX5 CTNNB1

4.54e-053136226843424
Pubmed

c-erbB-2 gene product directly associates with beta-catenin and plakoglobin.

ERBB2 CTNNB1

4.54e-05313627702605
Pubmed

PI3Kβ-regulated β-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression.

PIK3CB CTNNB1

4.54e-053136236179694
Pubmed

Comparing mechano-transduction in fibroblasts deficient of focal adhesion proteins.

BCAR1 VCL

4.54e-053136221924239
Pubmed

Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion.

PTPRU CTNNB1

4.54e-053136216574648
Pubmed

Relation among p130Cas, E-cadherin and beta-catenin expression, clinicopathologic significance and prognosis in human hepatocellular carcinoma.

BCAR1 CTNNB1

4.54e-053136218842495
Pubmed

Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells.

ERBB2 CTNNB1

4.54e-053136223576562
Pubmed

RIPK3 controls MAIT cell accumulation during development but not during infection.

CASP8 MLKL

4.54e-053136236774342
Pubmed

The interrelationship between HER2 and CASP3/8 with apoptosis in different cancer cell lines.

ERBB2 CASP8

4.54e-053136225189649
Pubmed

Expression of p130cas, E-cadherin and β-catenin and their correlation with clinicopathological parameters in non-small cell lung cancer: p130cas over-expression predicts poor prognosis.

BCAR1 CTNNB1

4.54e-053136223042269
Pubmed

Vinculin is associated with the E-cadherin adhesion complex.

CTNNB1 VCL

4.54e-05313629405455
Pubmed

Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.

APC2 CTNNB1

4.54e-053136210021369
Pubmed

ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas.

ERBB2 CTNNB1

4.54e-053136211950845
Pubmed

Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.

APC2 CTNNB1

4.54e-053136223840886
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

MYO10 TOMM70 SENP6 ADGRL3 ARAP1

4.98e-0510113659872452
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

FRMPD1 EFR3B NINL WDFY3 HPS5

5.22e-05102136510231032
Pubmed

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.

ERBB2 ARHGEF18 SNX14 RASA4

5.24e-0552136430655611
Pubmed

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

MCM2 INTS5 SENP6 RASA4B GCN1 SLX4 RNF111

8.12e-05262136736880596
Pubmed

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.

CASP8 MLKL

9.06e-054136230598363
Pubmed

The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2.

APC2 CTNNB1

9.06e-054136227068743
Pubmed

p130Cas promotes invasiveness of three-dimensional ErbB2-transformed mammary acinar structures by enhanced activation of mTOR/p70S6K and Rac1.

ERBB2 BCAR1

9.06e-054136220961652
Pubmed

Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription.

ERBB2 CTNNB1

9.06e-054136211245482
Pubmed

Analysis of c-ErbB1/epidermal growth factor receptor and c-ErbB2/HER-2 expression in bronchial dysplasia: evaluation of potential targets for chemoprevention of lung cancer.

ERBB2 MCM2

9.06e-054136216609045
Pubmed

Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2.

CTNNB1 VCL

9.06e-054136215579911
Pubmed

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis.

C7 C9

9.06e-054136225735751
Pubmed

Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.

RASA4 RASA4B

9.06e-054136216234249
Pubmed

Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis.

CASP8 MLKL

9.06e-054136236191211
Pubmed

Abl knockout differentially affects p130 Crk-associated substrate, vinculin, and paxillin in blood vessels of mice.

BCAR1 VCL

9.06e-054136219542491
Pubmed

ErbB2-positive mammary tumors can escape PI3K-p110α loss through downregulation of the Pten tumor suppressor.

ERBB2 PIK3CB

9.06e-054136228783168
Pubmed

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.

CASP8 MLKL

9.06e-054136227487218
Pubmed

Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin.

CTNNB1 VCL

9.06e-054136220086044
InteractionFLT3 interactions

USP17L21 ERBB2 USP17L12 USP17L20 USP17L11 USP17L19 TRRAP USP17L18 SAT1 USP17L17 CTNNB1 GCN1

8.97e-0731812812int:FLT3
Cytoband4p16.1

USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

2.46e-2379136154p16.1
CytobandEnsembl 112 genes in cytogenetic band chr4p16

USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

2.36e-1622213615chr4p16
Cytoband8p23.1

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

7.09e-0615413668p23.1
CytobandEnsembl 112 genes in cytogenetic band chr8p23

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

7.44e-052341366chr8p23
Cytoband18q21.31

NARS1 ALPK2

1.02e-0316136218q21.31
Cytoband9p13.2

FRMPD1 MELK

1.29e-031813629p13.2
Cytoband9q21.32

RASEF FRMD3

1.44e-031913629q21.32
Cytoband16q23.1

BCAR1 MLKL

4.08e-0332136216q23.1
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

ZFYVE9 ZFYVE26 WDFY3

3.06e-043177381
GeneFamilyPleckstrin homology domain containing|SH2 domain containing|C2 and RasGAP domain containing

RASA4 RASA4B

7.88e-0410772830
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

MYO10 FRMPD1 FRMD3

1.26e-03507731293
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

MYO10 ARHGEF18 AFAP1L2 RASA4B ARAP1

1.86e-03206775682
CoexpressionMADAN_DPPA4_TARGETS

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

3.17e-268613419MM1312
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

7.30e-2411213419MM1095
CoexpressionGERY_CEBP_TARGETS

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 SAT1 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.71e-2216013420MM1155
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 BCAR1 USP17L18 USP17L17 RASA4 USP17L6P USP17L3 RASA4B USP17L22 USP17L15 USP17L8 USP17L13

2.05e-1264713422MM981
CoexpressionGRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP

USP17L7 USP17L21 VPS18 USP17L4 USP17L2 USP17L12 USP17L1 HAP1 USP17L20 USP17L11 WDR46 USP17L5 USP17L10 USP17L19 BCAR1 USP17L18 USP17L17 JOSD2 RASA4 USP17L6P USP17L3 RASA4B USP17L22 USP17L15 ARAP1 USP17L8 USP17L13

1.12e-10122613427MM979
CoexpressionMARSON_BOUND_BY_FOXP3_STIMULATED

USP17L7 USP17L21 NCAPD3 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 BCAR1 ST13 USP17L18 USP17L17 POP5 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

5.35e-09107213423MM1031
CoexpressionBRUINS_UVC_RESPONSE_LATE

USP17L7 USP17L21 DOHH USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L5 CASP8 MCM2 USP17L10 USP17L19 USP17L18 MLKL USP17L17 USP17L6P USP17L3 USP17L22 AGRN USP17L15 USP17L8 USP17L13

8.97e-09119813424MM1062
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOHH DAPK2 LRFN3 PTPRU AP4E1 RHBDL3 SLX4 RNF111

1.84e-0815712884766f7d545bf2d775390589460677519cb92f4d5
ToppCellIIH-CD8-exh_CD4|IIH / Condition, Cell_class and T cell subcluster

DMGDH MIS18A ADGRV1 NCOA5 AP4E1 GAREM2 KLC3

3.21e-071541287a2f51a3c5455fe2483e438375ea856afce8262fe
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HAP1 MYO10 SEMA5A BCAR1 ARHGEF17 AFAP1L2 STARD9

1.18e-061871287a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCell(7)_Epithelial-I_(AT1)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ERBB2 DAPK2 SEMA5A EFR3B PATJ AGRN MVB12B

1.62e-061961287150554fa06868d29b0608189862eef6505ba757f
ToppCell10x5'-Lung-Myeloid_Mac-Intestinal_macrophages|Lung / Manually curated celltypes from each tissue

PALD1 MYO10 PTPRU ARHGEF17 C9 ALPK2

3.37e-0614112867671d300b1722711fd2d8034b96a3aa7e3ccb560
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-NP-L6_NP_ALM_Trh|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TRIM58 PTPRU NLRP6 RASA4 RHBDL3 KLC3

4.64e-061491286fe9dff31a30dabd212d53d1295f9f13ff32cb217
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARHGEF17 IL1RAPL1 HMCN2 KCNJ8 C7 FRMD3

1.24e-051771286bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HAP1 ARHGEF17 CENPP AFAP1L2 KCNJ8 AGRN

1.28e-051781286e5e4742e35c3d90f82b830d77bdbdc45828c7deb
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERBB2 ADGRV1 ITPKC DENND2C RASEF PATJ

1.32e-0517912866e965e424eebef50f0202cff75f458be395cfca1
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA5A ARHGEF17 AFAP1L2 KCNJ8 ADGRL3 VCL

1.41e-0518112861db1eb7d330a7e5090994007ae287e11f0a74450
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA5A ARHGEF17 AFAP1L2 KCNJ8 ADGRL3 VCL

1.41e-05181128606174ce9240c9261c0f51a1b0d875335d60722e5
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HAP1 SEMA5A ARHGEF17 AFAP1L2 KCNJ8 AGRN

1.64e-0518612866568358812f0ca4e0161a1a1b29682fbced35c79
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DAPK2 SEMA5A ADGRV1 JPH1 PATJ AGRN

1.69e-0518712864ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCellAT1-AT2_cells-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

DAPK2 SEMA5A KCNJ8 EFR3B AGRN FRMD3

1.75e-051881286be710bc957118cf426dd71c2d57e6f1b41c9a467
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

DAPK2 SEMA5A IL1RAPL1 PATJ ALPK2 VCL

1.80e-0518912869c1debd65c13d63fd4f3158917d621b44b714c26
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRV1 SAT1 NINL PATJ ALPK2 VCL

1.80e-0518912868c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCellMesenchymal-pericyte_cell|World / Lineage, Cell type, age group and donor

HAP1 MYO10 SEMA5A ARHGEF17 AFAP1L2 STARD9

1.80e-051891286d7ed96add29f219183c802895fbff519b627f635
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRV1 SAT1 NINL PATJ ALPK2 VCL

1.80e-0518912865d902a4660a27548764bf04c6de152b565da835c
ToppCellMild-T/NK_proliferative|World / Disease group and Cell class

NCAPD3 DYNC2I2 MIS18A MCM2 MELK CENPP

1.91e-0519112869dba5526fd5ea8065ad305feb2ee562335f887c6
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

HAP1 MYO10 SEMA5A ADGRV1 PPP1R17 JPH1

2.09e-0519412867c6c0376603e5fcb64814fd6204d153629c2fbf5
ToppCellnormal_Lung-Epithelial_cells-AT1|normal_Lung / Location, Cell class and cell subclass

ERBB2 DAPK2 SEMA5A EFR3B PATJ AGRN

2.15e-051951286569d1ebc5a5aa110a2430b096755ae35354040c4
ToppCellParenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HAP1 PRAMEF20 SEMA5A ARHGEF17 AFAP1L2 STARD9

2.27e-051971286f66945f9007d59d4208849c7fd727f8519713fbc
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Pericyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

HAP1 SEMA5A ARHGEF17 CENPP AFAP1L2 KCNJ8

2.27e-05197128644cd1ece3633a31e8c9b667cd3cbc2749c06f478
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NCAPD3 DYNC2I2 MIS18A MCM2 MELK CENPP

2.34e-0519812866981cd5b1585c8ae6febdf0c4fb83067127f106c
ToppCellsevere_influenza-T/NK_proliferative|severe_influenza / disease group, cell group and cell class (v2)

NCAPD3 DYNC2I2 MIS18A MCM2 MELK CENPP

2.41e-051991286638b1491c47f2884daf1c1d38a779ad8e0f59c52
ToppCell(7)_Epithelial_cells-(7)_Epithelial-I_(AT1)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

DAPK2 SEMA5A EFR3B AGRN FRMD3 MVB12B

2.41e-0519912865a002d49a8b84c158f7b4d7a3e78e6a937757bb7
ToppCelldistal-1-Epithelial-Proliferating_Basal|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NCAPD3 ADGRV1 MELK F12 KLC3 PMAIP1

2.41e-05199128693450257180d918c310bca7b5defc74390c48091
ToppCellCOVID-19-Lymphoid-Proliferating_CD4_T_cells|COVID-19 / Condition, Lineage and Cell class

NCAPD3 DYNC2I2 MIS18A MCM2 MELK CENPP

2.41e-051991286e1dfc856a85a91e8f7ab8d600a8a891d16b2aefb
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NCAPD3 DYNC2I2 MIS18A MCM2 MELK CENPP

2.41e-051991286616c04b0605907fb218263f2164c36cb2fa26b87
ToppCellMild-T/NK_proliferative|Mild / Disease group and Cell class

NCAPD3 DYNC2I2 MIS18A MCM2 MELK CENPP

2.41e-05199128664a5c91243ee999ea21ffddd450d3e5fdbf6470b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells|GW13 / Sample Type, Dataset, Time_group, and Cell type.

NCAPD3 MIS18A NVL PPP1R17 MELK CENPP

2.47e-052001286d933978b55fefe52cad599b36f6b47a0c7f71f96
ToppCelldistal-Epithelial-Proliferating_Basal|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NCAPD3 ADGRV1 MELK F12 KLC3 PMAIP1

2.47e-05200128625cc494ef831511840d8c02ec1bd086635cc7edd
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ERBB2 DAPK2 ADGRV1 PTPRU PATJ KLC3

2.47e-0520012868683445ad5b70748c4a1f12eb77d47623085147e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells-Neuroepithelial_cell|GW13 / Sample Type, Dataset, Time_group, and Cell type.

NCAPD3 MIS18A NVL PPP1R17 MELK CENPP

2.47e-0520012863d932765c31aef1f80a118d51e8e66c50a758dbb
ToppCelldistal-Epithelial-Proliferating_Basal-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NCAPD3 ADGRV1 MELK F12 KLC3 PMAIP1

2.47e-052001286cc31e8c28d01e6757c5dd7f485db6acf7409a47e
ToppCellParenchymal-10x3prime_v2-Hematologic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRIM58 GAREM2 SLX4

4.94e-052512837b267cdcb6afcf603d566c4d5268eb44eacf47b6
ToppCellParenchymal-10x3prime_v2-Hematologic-Erythrocyte|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRIM58 GAREM2 SLX4

4.94e-05251283096ca30d9277cfd9cb2501c40b085cc358cb628b
ToppCellParenchymal-10x3prime_v2-Hematologic-Erythrocyte-Erythrocyte|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRIM58 GAREM2 SLX4

4.94e-052512833d7b43ecf6ae64996d91765c50f614742e18bd25
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

APC2 MELK CENPP TELO2 RHBDL3

5.11e-051391285c9bf98bed77415a1438f3f9e441a1346e75c26b0
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PALD1 TIGD7 PTPRU MYCBPAP XPO6

5.65e-051421285d52da766e031f7409eb5a7a9fa88f48e14a79d8b
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PALD1 TIGD7 PTPRU MYCBPAP XPO6

5.65e-051421285a05b320cf182b2aaf18df7c40045dc65b659bf20
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DAPK2 ARHGEF17 IL1RAPL1 AFAP1L2 STARD9

1.12e-041641285f6a961fa2002da7d9679f32af99e1314c0593ef9
ToppCellfacs-Lung-EPCAM-3m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCAR1 MTMR11 TBCK AGRN MVB12B

1.12e-0416412851d0d88132baaa3154c3e6e4ef0aff795afab08a2
ToppCellfacs-Lung-EPCAM-3m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCAR1 MTMR11 TBCK AGRN MVB12B

1.12e-041641285bd2e10b015d5e6a338675500ec5d81dc39583b3e
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|343B / Donor, Lineage, Cell class and subclass (all cells)

NCAPD3 ARHGEF18 MCM2 MELK F12

1.21e-0416712857efa0081e79f22b219eac64ffcaedb2179cde299
ToppCelldroplet-Heart-nan-24m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO10 NUP88 SYBU EFR3B HPS5

1.21e-041671285a35ace2c722936d2a3e1f0826e5b6ec6b1340d2b
ToppCellBAL-Control-cDC_6|Control / Compartment, Disease Groups and Clusters

NCAPD3 DYNC2I2 MYO10 ARHGEF18 DENND2C

1.25e-04168128565ec473cff748b334c0a66e33bc34a8465fe7631
ToppCell3'-Adult-SmallIntestine-Hematopoietic-B_cells-Cycling_B_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLHL6 PALD1 DOK3 NLRP6 PAX5

1.28e-041691285203971cceeba150d0e8891c92662545e84c77837
ToppCelldroplet-Spleen-nan-3m-Myeloid-macrophage|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HAP1 PIK3CB RASA4 ADGRL3 PMAIP1

1.36e-0417112855b74df72e36ad04dfb25c72f1ca8efe043f6cda6
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

DMGDH DOHH FRMPD1 NYNRIN RASA4B

1.36e-0417112857c8304573b892ef9ea4e048cba9ea9fbab848dcd
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

NCAPD3 ARHGEF18 MCM2 MELK PAX5

1.39e-041721285e9b97f37bb1732ad9aa89c5e9b513d14022801ac
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DAPK2 ARHGEF17 IL1RAPL1 AFAP1L2 STARD9

1.39e-04172128508a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DAPK2 ARHGEF17 IL1RAPL1 AFAP1L2 STARD9

1.39e-041721285553701349444eb366df3c11f54bb093434f153c6
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DAPK2 ARHGEF17 IL1RAPL1 C7 VCL

1.51e-0417512851b4cefae400bf756d09ece32d3f5c0bd4c6ad73f
ToppCell367C-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DYNC2I2 MIS18A MCM2 MELK CENPP

1.51e-0417512850b1aaa028ba844d4bcb4509fdab8bee648373935
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYO10 SEMA5A ARHGEF17 AFAP1L2 STARD9

1.64e-041781285185b44700f06ec58b3c09c80520502166c965fd6
ToppCell343B-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NCAPD3 DYNC2I2 MCM2 MELK CENPP

1.64e-041781285c7e890cd02206c516cf1d7692ea7abc8ce746482
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APC2 SEMA5A CABLES1 KCNJ8 TBCK

1.68e-041791285e880c507f11ce75d104593a4ca29f0295f8125e8
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA5A ARHGEF17 IL1RAPL1 KCNJ8 ADGRL3

1.68e-041791285a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCellAT1_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

DAPK2 SEMA5A AGRN VCL FRMD3

1.72e-0418012852d52cb5f77dde0e3dccac1333d4ec67ec680fcb2
ToppCell5'-Adult-SmallIntestine-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCNJ8 MDH1B EFR3B ADGRL3 VCL

1.77e-041811285fc51468c74534b60b4e786bd512d0f1c5dc05de7
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYO10 SEMA5A ARHGEF17 AFAP1L2 STARD9

1.77e-041811285451b87ac95154bb80018b8dd245b4a6389d81411
ToppCellCOVID-19-Heart-Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

SEMA5A ARHGEF17 KCNJ8 ADGRL3 FRMD3

1.77e-04181128533cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ERBB2 DAPK2 SEMA5A PATJ AGRN

1.77e-041811285b45b11428d13950369347e051d4d517efb2bd4fd
ToppCellfacs-Heart-LV-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOK3 ARHGEF18 NLRP6 PAX5 PMAIP1

1.77e-04181128557f82f54e20e19aa17a2ea22af22e3bc8965d622
ToppCellfacs-Heart-LV-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOK3 ARHGEF18 NLRP6 PAX5 PMAIP1

1.77e-0418112858855812c85ef45c1be6bd511619b2dfe5e441264
ToppCellfacs-Heart-LV-18m-Lymphocytic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOK3 ARHGEF18 NLRP6 PAX5 PMAIP1

1.81e-041821285d0d18dd5d8b2d21e42c3c4259f824c91f24a54bc
ToppCell343B-Lymphocytic-NK_cells-Proliferating_NK_cell|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

NCAPD3 DYNC2I2 MCM2 MELK CENPP

1.81e-041821285b1e66ccd5f33b4801f1cafddf97f5fc0c6dba8d1
ToppCellCOVID-19-lung-AT1|lung / Disease (COVID-19 only), tissue and cell type

DAPK2 ADGRV1 JPH1 EFR3B PATJ

1.86e-041831285942530449e9c6583705eeb8f6f12621daea57252
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l14|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NCAPD3 DAPK2 CABLES1 ITPKC KLC3

1.86e-0418312856e5b39c0170d62eb7fdd411dcfff51ed176573d0
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NCAPD3 DOHH DYNC2I2 MCM2 MELK

1.91e-041841285a0831e850bc0b585296ed350fdd075c1f730308e
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1|Children_(3_yrs) / Lineage, Cell type, age group and donor

DAPK2 SEMA5A EFR3B PATJ FRMD3

1.96e-0418512851c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HAP1 MYO10 SEMA5A ARHGEF17 AFAP1L2

1.96e-041851285a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma-muscle|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

DMGDH ERBB2 PCDHGA3 JPH1 STARD9

1.96e-0418512850094f9baddb20214d2a2c166f1637d1a9cf1169a
ToppCellLA-07._Pericyte|LA / Chamber and Cluster_Paper

SEMA5A ARHGEF17 KCNJ8 ADGRL3 FRMD3

1.96e-041851285ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TBCK NINL PATJ HPS5 VPS13B

2.01e-04186128577bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCellEpithelial-alveolar_epithelial_cell_type_1|World / Lineage, Cell type, age group and donor

DAPK2 SEMA5A EFR3B PATJ AGRN

2.01e-04186128509d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TBCK NINL PATJ HPS5 VPS13B

2.01e-04186128513bc41c60fd628af31899a5e8b480e06cc4781be
ToppCell5'-Adult-LargeIntestine-Mesenchymal-Pericytes-Pericyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA5A ARHGEF17 KCNJ8 ADGRL3 FRMD3

2.01e-0418612850c477016c1b539b3086a8066c3c6443f08c222a3
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DAPK2 ARHGEF17 IL1RAPL1 C7 VCL

2.06e-041871285d591a3c216997663ab77710fed0d230ffc37e41a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A ARHGEF17 IL1RAPL1 STARD9 ADGRL3

2.06e-04187128548bfdb3504c3fefe5db3abac4b790c369680ab4e
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DAPK2 ARHGEF17 IL1RAPL1 C7 VCL

2.06e-041871285d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DAPK2 ARHGEF17 IL1RAPL1 C7 VCL

2.06e-041871285ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|368C / Donor, Lineage, Cell class and subclass (all cells)

DAPK2 NINL RASEF PATJ AGRN

2.06e-041871285b827d9da7032bf051756ddf88352af922eb0f87b
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|368C / Donor, Lineage, Cell class and subclass (all cells)

DAPK2 NINL RASEF PATJ AGRN

2.06e-04187128561c00604dda8b36a5c3eea6554e5601aa1b884f7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NCAPD3 MELK CENPP AFAP1L2 EFR3B

2.06e-041871285057569c9437219ecc396aa6e673b1178a2273837
ToppCellRV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

DAPK2 SEMA5A IL1RAPL1 PATJ ALPK2

2.06e-04187128578cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A ARHGEF17 IL1RAPL1 STARD9 ADGRL3

2.06e-041871285958402fcc78f4c7a7d13d659d776f3817137975f
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R17 RASA4 PATJ ALPK2 FRMD3

2.11e-0418812851efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYO10 SEMA5A ARHGEF17 AFAP1L2 STARD9

2.11e-041881285ee151792c7ac9afe820f1a281c6dab383799f358
ToppCellIPF-Myeloid-ncMonocyte|Myeloid / Disease state, Lineage and Cell class

ARHGEF18 PPP1R17 NLRP6 SAT1 XPO6

2.16e-0418912855c22d2d935f7bb270260b8bc6be67b565ec401bf
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D231|Adult / Lineage, Cell type, age group and donor

DAPK2 SEMA5A EFR3B PATJ FRMD3

2.16e-0418912855a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DAPK2 ADGRV1 CABLES1 JPH1 PATJ

2.21e-0419012858aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCellCOPD-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

ARHGEF18 PPP1R17 SAT1 XPO6 VCL

2.21e-041901285aece860b5609ad5a8fc920d685f0d0ec71bf9018
ToppCellCOPD-Myeloid-ncMonocyte|Myeloid / Disease state, Lineage and Cell class

ARHGEF18 PPP1R17 SAT1 XPO6 VCL

2.21e-041901285ed978cd5d9da87b49878a330e362762c487f849f
ToppCellIPF-Epithelial-Basal|IPF / Disease state, Lineage and Cell class

SEMA5A PTPRU DENND2C RASEF PATJ

2.21e-041901285ea19e9ce954f2dfde97388db9695325cd92ab88f
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MYO10 SEMA5A ARHGEF17 AFAP1L2 STARD9

2.21e-0419012854eb92aef1ee868f4537483d19014d947b7684612
ToppCellfacs-Heart-RA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF17 GAREM2 KCNJ8 ADGRL3 VCL

2.21e-041901285bfbdf16d488359d7935a419c4c1823288f39c183
ToppCellfacs-Heart-RA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF17 GAREM2 KCNJ8 ADGRL3 VCL

2.21e-041901285eb1f8bb4d903b08e50c2dc173b06c0c79d8e316e
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DAPK2 SEMA5A PATJ VCL FRMD3

2.21e-04190128530b50d183d7649146eb1e79b47ba897355f1998a
Diseaseprimary ovarian insufficiency (implicated_via_orthology)

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

1.16e-354613220DOID:5426 (implicated_via_orthology)
Diseasecongenital heart disease (implicated_via_orthology)

USP17L7 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L3 USP17L22 USP17L15 USP17L8 USP17L13

2.20e-316913220DOID:1682 (implicated_via_orthology)
Diseasecardiac troponin I measurement

LCORL MYO10 TOR4A F12 TAF3 VCL MVB12B

1.50e-051761327EFO_0010071
Diseasecalcinosis (is_marker_for)

ERBB2 CTNNB1

2.94e-0461322DOID:182 (is_marker_for)
DiseaseOvarian neoplasm

ERBB2 CTNNB1

4.11e-0471322cv:C0919267
Diseaseinvasive lobular carcinoma (is_marker_for)

ERBB2 CTNNB1

4.11e-0471322DOID:3457 (is_marker_for)
DiseaseHEPATOCELLULAR CARCINOMA

CASP8 CTNNB1

7.00e-0491322114550
DiseaseAdult Hepatocellular Carcinoma

CASP8 CTNNB1

7.00e-0491322C0279607
DiseaseHepatocellular carcinoma

CASP8 CTNNB1

7.00e-0491322cv:C2239176
DiseaseGlioma

ERBB2 CTNNB1

7.00e-0491322cv:C0017638
DiseaseNeoplasm of uncertain or unknown behavior of breast

ERBB2 CASP8 PIK3CB

8.24e-04411323C0496956
DiseaseBreast adenocarcinoma

ERBB2 CASP8 PIK3CB

8.24e-04411323C0858252
Diseasedipeptidase 2 measurement

F12 DUS2

8.73e-04101322EFO_0801528
DiseaseHead and Neck Carcinoma

ERBB2 PIK3CB

8.73e-04101322C3887461
DiseaseAdenocarcinoma of large intestine

ERBB2 TRRAP TBCK CTNNB1

9.25e-04961324C1319315
DiseaseGastric Adenocarcinoma

TRRAP MLKL CTNNB1

1.08e-03451323C0278701
Diseasemembranous glomerulonephritis (biomarker_via_orthology)

PTPRU C7

1.74e-03141322DOID:10976 (biomarker_via_orthology)
DiseaseNeoplasm of lung

ERBB2 CASP8

1.74e-03141322cv:C0024121
DiseaseLung cancer

ERBB2 CASP8

1.74e-03141322cv:C0242379
Diseaseautosomal dominant polycystic kidney disease (is_marker_for)

GPBAR1 C9

1.74e-03141322DOID:898 (is_marker_for)
DiseaseLUNG CANCER

ERBB2 CASP8

1.74e-03141322211980
Diseasepolycystic kidney disease (biomarker_via_orthology)

GPBAR1 C9

3.23e-03191322DOID:0080322 (biomarker_via_orthology)
DiseaseHIV-1 infection, Susceptibility to viral and mycobacterial infections

FRMPD1 PAX5

3.94e-03211322EFO_0000180, Orphanet_391311
Diseaseopioid dependence

ADGRV1 BCAR1 NCOA5 C9 RNF111

4.34e-032371325EFO_0005611

Protein segments in the cluster

PeptideGeneStartEntry
IDSECRPRFRELVSE

ERBB2

961

P04626
RRLSLDASAVDEEPC

ARHGEF18

91

Q6ZSZ5
LDRLVACSRAVPEDA

BCAR1

576

P56945
LTLENVCDEPRDREA

ALPK2

786

Q86TB3
CPERALERREEEANV

AGRN

31

O00468
IPALEESCEAVEARE

ADGRL3

491

Q9HAR2
VFILDPECLEREVAE

ADGRV1

1241

Q8WXG9
PECLEREVAEDVLSE

ADGRV1

1246

Q8WXG9
EECRGEESRRVDLEL

AFAP1L2

721

Q8N4X5
LQAEIAALRRACEDP

CENPP

11

Q6IPU0
HADDPERVVRESCEV

DOHH

261

Q9BU89
REFDDLPLAEQREAC

ATP2A1

656

O14983
LLPVDRSCEDLVVDA

AP4E1

606

Q9UPM8
AAIRDCDRAIEINPD

ST13

166

P50502
RCSVLEARDLAPKDR

RASA4

136

O43374
RCSVLEARDLAPKDR

RASA4B

136

C9J798
EEFRALCTELRVRPA

RASEF

31

Q8IZ41
LCTELRVRPADAEAV

RASEF

36

Q8IZ41
VACLEELREALEISP

ITPKC

596

Q96DU7
DEVDALCPRRSDRET

NVL

681

O15381
ELPSCELSRLEEIAE

PPP4R3A

131

Q6IN85
FCVREEPVLFLRADE

PALD1

161

Q9ULE6
DRLLAERVCDNDTVP

PAX5

116

Q02548
RFDILCVVRDTVDPV

MCM2

656

P49736
VISPERRCRSVELDL

MELK

496

Q14680
LSLRAEPDVEACIAV

ARHGEF17

1531

Q96PE2
DREDITEPAICALRH

CTNNB1

456

P35222
ERFVAEVTCLDPLRR

KLHL6

331

Q8WZ60
VKVAAPRCSARELDE

KCNJ8

346

Q15842
VDARNPLLFRCEDLE

LSG1

181

Q9H089
RLRALCLPDSSVAED

MTMR11

321

A4FU01
RLERAVCRDEPSALA

GPBAR1

201

Q8TDU6
DAPCELLRVQLERVA

EDRF1

1071

Q3B7T1
VRAVAEEEVLLPCEA

HMCN2

3951

Q8NDA2
EPCARACRSDLDERE

C17orf58

191

Q2M2W7
ERPEVLSLARELRTC

FAM43B

286

Q6ZT52
RRDLSLFEDCEPEEL

LCORL

66

Q8N3X6
DVSDRLRALAPSAEC

MCM3AP

1271

O60318
ACECVRSPRESLDDL

HPS5

706

Q9UPZ3
EAADEICKRLAPDSR

JOSD2

41

Q8TAC2
ECDIARAVARELSPD

JPH1

401

Q9HDC5
PREAEDLDCLAAEVA

DYNC2I2

521

Q96EX3
EISCRDIEDFLLPTR

IL1RAPL1

161

Q9NZN1
EEIQRRFDAERPVDC

NCOA5

186

Q9HCD5
RFDAERPVDCSVIVV

NCOA5

191

Q9HCD5
ESPAELAERCLRELL

EFR3B

226

Q9Y2G0
CREFVPSRDEIEALI

MYO10

1681

Q9HD67
RVIRLADCVSVLPAD

DOK3

126

Q7L591
AVPLCRQALEDLERS

KLC3

226

Q6P597
RKALCDPLEEVREAA

GCN1

2011

Q92616
PCALRELSVDLRAER

AMH

461

P03971
RRLAREDDLEACASP

LRFN3

261

Q9BTN0
VAPQSRELLRCLEEE

HAUS5

436

O94927
DCPSELREIIDECRA

MLKL

436

Q8NB16
LREIIDECRAHDPSV

MLKL

441

Q8NB16
IPRDSTEAAICDIRI

MVB12B

151

Q9H7P6
DVEECSIALLPRNRD

PTPRU

1191

Q92729
TAERIDREELCAQIP

PCDHGA3

86

Q9Y5H0
CELVSDDPRCRLSLD

POP5

11

Q969H6
DDPRCRLSLDDRVLS

POP5

16

Q969H6
RPDEVLECIERGVDL

QTRT2

256

Q9H974
LFDCPSRLELEREDT

FRMD3

466

A2A2Y4
LDIADCRERCRLPSE

APC2

1241

O95996
RAPAELEVECATQLR

PMAIP1

16

Q13794
VLPVDLERERAALCA

DOCK8-AS1

121

Q5T8R8
EDIEENAPLRRCRTL

CABLES1

296

Q8TDN4
VHLRPDEDLRNCESD

DAPK2

336

Q9UIK4
EVDCVLEPLSDRRLV

FRMPD1

531

Q5SYB0
ERAAFIRELEEALCP

HAP1

146

P54257
EDRCEDSERRPSCDI

C7

116

P10643
DESIELCRPLDSRLE

DENND2C

651

Q68D51
ERCPRGDDILTILTE

CASP8

431

Q14790
EVFTLEDCLRSRVPL

MDH1B

221

Q5I0G3
RLVCLTLATDDVDPE

DMGDH

771

Q9UI17
VAPDDRVVFRTCERE

DUS2

66

Q9NX74
TRSLADLILDQCPDR

NLRP6

246

P59044
PDAVCRDLSEALRAA

NLRP6

741

P59044
PCRDRVVEESELART

C9

141

P02748
VFRVECPSLSEEILR

NYNRIN

1026

Q9P2P1
LCTREDVEVAESPLR

NUP88

506

Q99567
PLVCEDQAAERRLTL

F12

566

P00748
AELAEDCASPRRARL

GAREM2

366

Q75VX8
IDAVIARACAEREPD

TAF3

391

Q5VWG9
RCPEDSRLTESVDVL

NARS1

451

O43776
VAACAEAERIEELEP

RHBDL3

11

P58872
LADRCPALEELDLTA

FBXL15

161

Q9H469
VRALREPERILFCTD

PRAMEF20

441

Q5VT98
EKDPDEDCRTLALRA

TELO2

806

Q9Y4R8
IRPATAADCSDILRL

SAT1

6

P21673
LTETALEIPACREVR

STARD9

1756

Q9P2P6
AVPDTVREACDRLIQ

INTS5

426

Q6P9B9
ELEDETRRLCDVRPF

PIK3CB

91

P42338
ELCDAATEARRVPEQ

NINL

116

Q9Y2I6
PERLRHASEECSLEA

SLX4

221

Q8IY92
SSCLLEEIELFPERR

SEMA5A

441

Q13591
TCFEVNEREEAERPL

ARAP1

1221

Q96P48
SIPALVRELEVCEDV

NCAPD3

941

P42695
ELSEDRLDKLDPRCS

PPP1R17

11

O96001
ETRVDLCDDLAPVAR

USP17L3

46

A6NCW0
DPREFIRVHREALEC

WDFY3

2886

Q8IZQ1
ETRVDLCDDLAPVAR

USP17L4

46

A6NCW7
EEAAAAEERPLVFLC

MIS18A

71

Q9NYP9
LSILEEGEDVRRLPC

RNF111

946

Q6ZNA4
CLTVEEFNDRILRPE

SNX14

366

Q9Y5W7
ACVEERLDGVIPLAR

SYBU

581

Q9NX95
CRRLFDDEASVDEPR

PATJ

636

Q8NI35
RERPDCLDTVLAREA

VPS18

416

Q9P253
ETRVDLCDDLAPVAR

USP17L18

46

D6R9N7
ALAEARKIAELCDDP

VCL

411

P18206
ETRVDLCDDLAPVAR

USP17L5

46

A8MUK1
LEPEALREHCRRAAE

UAP1L1

41

Q3KQV9
ETRVDLCDDLAPVAR

USP17L21

46

D6R901
ETRVDLCDDLVPEAR

USP17L13

46

C9JLJ4
EERELIDCTLPTRRD

MYCBPAP

246

Q8TBZ2
ENTCRAERELRSIPE

SENP6

376

Q9GZR1
VADFDECIRLRPESA

TOMM70

421

O94826
ETRVDLCDDLAPVAR

USP17L19

46

D6RCP7
ETRVDLCDDLAPVAR

USP17L1

46

Q7RTZ2
LFSDLPEIDIERCVR

TBCK

681

Q8TEA7
AELICLDPRALAEVD

WDR46

511

O15213
PEARAAQDCREELAR

TOR4A

231

Q9NXH8
ETRVDLCDDLAPVAR

USP17L12

46

C9JPN9
ETRVDLCDDLAPVAR

USP17L24

46

Q0WX57
ACDVEVDGVRERLSE

VPS13B

3936

Q7Z7G8
ETRFDLCDDLAPVAR

USP17L7

46

P0C7H9
ETRVDLCDDLAPVAR

USP17L8

46

P0C7I0
ETRVDLCDDLAPVAR

USP17L6P

46

Q6QN14
ELACPREDLSVARKE

XPO6

156

Q96QU8
ETRVDLCDDLAPVAR

USP17L22

46

D6RA61
DEDVRALLLLDSCPA

TIGD7

286

Q6NT04
ETRVDLCDDLAPVAR

USP17L15

46

C9J2P7
ETRVDLCDDLAPVAR

USP17L17

46

D6RBQ6
PLAAEQVARECERLL

ZFYVE26

1346

Q68DK2
RCATPLKDEERAEEI

TRRAP

1216

Q9Y4A5
ETRVDLCDDLAPVAR

USP17L23

46

D6RBM5
ERCSDCLVPNEVRAD

ZFYVE9

356

O95405
REDARCPVCLDFLQE

TRIM58

11

Q8NG06
EARVDLCDDLAPVAR

USP17L2

46

Q6R6M4
ETRVDLCDDLAPVAR

USP17L20

46

D6RJB6
ETRVDLCDDLAPVAR

USP17L10

46

C9JJH3
ILTRIERGEEPCLDR

ZNF783

191

Q6ZMS7
ETRVDLCDDLAPVAR

USP17L11

46

C9JVI0