Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainNotch

NOTCH3 NOTCH4

4.03e-054492IPR008297
DomainNODP

NOTCH3 NOTCH4

4.03e-054492PF07684
DomainNotch_NODP_dom

NOTCH3 NOTCH4

4.03e-054492IPR011656
DomainNotch_NOD_dom

NOTCH3 NOTCH4

4.03e-054492IPR010660
DomainNOD

NOTCH3 NOTCH4

4.03e-054492PF06816
DomainNOD

NOTCH3 NOTCH4

4.03e-054492SM01338
DomainNODP

NOTCH3 NOTCH4

4.03e-054492SM01339
DomainLNR

NOTCH3 NOTCH4

6.71e-055492PS50258
DomainNotch_dom

NOTCH3 NOTCH4

1.40e-047492IPR000800
DomainNotch

NOTCH3 NOTCH4

1.40e-047492PF00066
DomainNL

NOTCH3 NOTCH4

1.40e-047492SM00004
DomainEGF_3

TENM3 MATN2 NOTCH3 NOTCH4 IMPG2

3.67e-04235495PS50026
DomainEGF-like_dom

TENM3 MATN2 NOTCH3 NOTCH4 IMPG2

4.78e-04249495IPR000742
DomainEGF-like_CS

TENM3 MATN2 NOTCH3 NOTCH4 IMPG2

5.92e-04261495IPR013032
DomainEGF_2

TENM3 MATN2 NOTCH3 NOTCH4 IMPG2

6.34e-04265495PS01186
DomainGrowth_fac_rcpt_

ERBB4 MATN2 NOTCH3 NOTCH4

7.41e-04156494IPR009030
DomainWAP

WFIKKN2 WFDC5

7.90e-0416492SM00217
DomainWAP

WFIKKN2 WFDC5

7.90e-0416492PF00095
DomainWAP

WFIKKN2 WFDC5

8.94e-0417492PS51390
Domain-

WFIKKN2 WFDC5

8.94e-04174924.10.75.10
DomainRib_L2_dom2

CUL9 UHRF2

1.00e-0318492IPR014722
Domain-

CUL9 UHRF2

1.00e-03184922.30.30.30
DomainEGF_CA

MATN2 NOTCH3 NOTCH4

1.49e-0386493PF07645
DomainWAP_dom

WFIKKN2 WFDC5

1.51e-0322492IPR008197
DomainASX_HYDROXYL

MATN2 NOTCH3 NOTCH4

2.30e-03100493PS00010
DomainhEGF

NOTCH3 NOTCH4

2.44e-0328492PF12661
DomainEGF-type_Asp/Asn_hydroxyl_site

MATN2 NOTCH3 NOTCH4

2.71e-03106493IPR000152
DomainEGF

TENM3 MATN2 NOTCH3 NOTCH4

3.32e-03235494SM00181
DomainEGF_CA

MATN2 NOTCH3 NOTCH4

4.02e-03122493SM00179
DomainEGF-like_Ca-bd_dom

MATN2 NOTCH3 NOTCH4

4.21e-03124493IPR001881
DomainEGF

MATN2 NOTCH3 NOTCH4

4.41e-03126493PF00008
DomainEGF_1

TENM3 NOTCH3 NOTCH4 IMPG2

4.44e-03255494PS00022
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH3 NOTCH4

3.26e-055262M27411
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH3 NOTCH4

3.26e-055262MM14733
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH3 NOTCH4

4.88e-056262M27068
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

NOTCH3 NOTCH4

6.83e-057262MM14734
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH3 NOTCH4

1.78e-0411262M47865
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH3 NOTCH4

2.13e-0412262M47532
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH3 NOTCH4

2.13e-0412262M47533
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

NOTCH3 NOTCH4

2.52e-0413262M47423
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH3 NOTCH4

2.52e-0413262M47534
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH3 NOTCH4

4.91e-0418262M614
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

NOTCH3 NOTCH4

8.08e-0423262MM14954
PathwayKEGG_DORSO_VENTRAL_AXIS_FORMATION

NOTCH3 NOTCH4

8.81e-0424262M11190
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

NOTCH3 NOTCH4

1.12e-0327262M39545
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

NOTCH3 NOTCH4

1.20e-0328262M6177
PathwayWP_OSX_AND_MIRNAS_IN_TOOTH_DEVELOPMENT

NOTCH3 NOTCH4

1.77e-0334262M39390
PathwayWP_NEOVASCULARIZATION_PROCESSES

NOTCH3 NOTCH4

2.09e-0337262M39506
Pubmed

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.

DAB2IP IGF2R ANK2 TENM3 CUL9 PLEKHM1 ITFG1

1.00e-0637150715747579
Pubmed

Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice.

NOTCH3 NOTCH4

2.03e-06250233665264
Pubmed

Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma.

NOTCH3 NOTCH4

2.03e-06250217696940
Pubmed

Novel Roles for Notch3 and Notch4 Receptors in Gene Expression and Susceptibility to Ozone-Induced Lung Inflammation in Mice.

NOTCH3 NOTCH4

2.03e-06250225658374
Pubmed

Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1.

WFIKKN2 CNR1

2.03e-06250220164830
Pubmed

A genetic determinant that specifically regulates the frequency of hematopoietic stem cells.

NOTCH3 NOTCH4

2.03e-06250211777956
Pubmed

Notch receptor expression in human brain arteriovenous malformations.

NOTCH3 NOTCH4

6.07e-06350225846406
Pubmed

Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype.

NOTCH3 NOTCH4

6.07e-06350215645445
Pubmed

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

B3GNT4 MATN2 WFIKKN2 WFDC5 CXCL16 LUZP2 SPACA5 TNMD RSPRY1

9.98e-0698550912975309
Pubmed

Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.

NOTCH3 NOTCH4

1.21e-05450228061457
Pubmed

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.

NOTCH3 NOTCH4

1.21e-05450224145721
Pubmed

A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.

NOTCH3 NOTCH4

1.21e-05450220069356
Pubmed

Expression and clinical significance of Notch receptors in human renal cell carcinoma.

NOTCH3 NOTCH4

1.21e-05450219404845
Pubmed

Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.

NOTCH3 NOTCH4

1.21e-05450228669409
Pubmed

Evolutionary analysis of vertebrate Notch genes.

NOTCH3 NOTCH4

1.21e-05450211466531
Pubmed

Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.

NOTCH3 NOTCH4

1.21e-05450224151014
Pubmed

Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.

NOTCH3 NOTCH4

1.21e-05450211401408
Pubmed

Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.

NOTCH3 NOTCH4

1.21e-05450210194420
Pubmed

Functional conservation of mouse Notch receptor family members.

NOTCH3 NOTCH4

1.21e-0545028898100
Pubmed

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.

NOTCH3 NOTCH4

1.21e-05450211459941
Pubmed

MicroRNA-183 suppresses cancer stem-like cell properties in EBV-associated nasopharyngeal carcinoma.

NOTCH3 NOTCH4

1.21e-05450227431799
Pubmed

Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.

NOTCH3 NOTCH4

1.21e-05450218184405
Pubmed

Notch signaling in the mammalian central nervous system: insights from mouse mutants.

NOTCH3 NOTCH4

1.21e-05450215917835
Pubmed

Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.

NOTCH3 NOTCH4

1.21e-05450223444212
Pubmed

Deregulated expression of Notch receptors in human hepatocellular carcinoma.

NOTCH3 NOTCH4

1.21e-05450217920003
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

ERBB4 CR2 NOTCH3 IMPG2

1.39e-0510150423382219
Pubmed

Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.

NOTCH3 NOTCH4

2.02e-05550221726900
Pubmed

Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.

NOTCH3 NOTCH4

2.02e-05550221124806
Pubmed

Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).

NOTCH3 NOTCH4

2.02e-05550223675950
Pubmed

Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells.

NOTCH3 NOTCH4

2.02e-05550221602525
Pubmed

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.

NOTCH3 NOTCH4

2.02e-05550211101851
Pubmed

Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.

NOTCH3 NOTCH4

2.02e-05550215882997
Pubmed

Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1.

NOTCH3 NOTCH4

2.02e-05550220554499
Pubmed

Functional proteomics mapping of a human signaling pathway.

KIF18A TENM3 ZFYVE16 ZNF451 PYCR2 DNAJC7 UHRF2

2.09e-0559150715231748
Pubmed

RBP-L, a transcription factor related to RBP-Jkappa.

NOTCH3 NOTCH4

3.03e-0565029111338
Pubmed

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.

NOTCH3 NOTCH4

3.03e-05650220870902
Pubmed

A study on Notch signaling in human breast cancer.

NOTCH3 NOTCH4

3.03e-05650217822320
Pubmed

Characterization of Notch receptor expression in the developing mammalian heart and liver.

NOTCH3 NOTCH4

3.03e-05650212244553
Pubmed

Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.

NOTCH3 NOTCH4

3.03e-05650219503073
Pubmed

Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.

NOTCH3 NOTCH4

3.03e-0565027835890
Pubmed

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

NOTCH3 NOTCH4

3.03e-05650218299578
Pubmed

Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.

NOTCH3 NOTCH4

3.03e-05650215019995
Pubmed

Notch controls the magnitude of T helper cell responses by promoting cellular longevity.

NOTCH3 NOTCH4

3.03e-05650222615412
Pubmed

Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice.

NOTCH3 NOTCH4

3.03e-05650221991352
Pubmed

Human ligands of the Notch receptor.

NOTCH3 NOTCH4

4.23e-05750210079256
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

NOTCH3 NOTCH4

4.23e-05750212846471
Pubmed

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.

NOTCH3 NOTCH4

4.23e-05750211518718
Pubmed

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium.

NOTCH3 NOTCH4

4.23e-05750211344305
Pubmed

Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients.

NOTCH3 NOTCH4

5.64e-05850222156581
Pubmed

Notch1 and Jagged1 expression by the developing pulmonary vasculature.

NOTCH3 NOTCH4

5.64e-05850212242716
Pubmed

Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

NOTCH3 NOTCH4

5.64e-0585029858718
Pubmed

Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.

NOTCH3 NOTCH4

7.25e-05950211118901
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

NOTCH3 NOTCH4

7.25e-05950216245338
Pubmed

Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.

NOTCH3 NOTCH4

7.25e-05950212370315
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

NOTCH3 NOTCH4

9.05e-051050223665443
Pubmed

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein.

NOTCH3 NOTCH4

9.05e-051050214766969
Pubmed

Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.

NOTCH3 NOTCH4

9.05e-051050233915108
Pubmed

Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.

NOTCH3 NOTCH4

1.10e-041150216607638
Pubmed

Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

NOTCH3 NOTCH4

1.10e-041150215499562
Pubmed

Developmental regulation of membrane traffic organization during synaptogenesis in mouse diaphragm muscle.

IGF2R TASOR2

1.10e-04115027642711
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

NOTCH3 NOTCH4

1.10e-041150210878608
Pubmed

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

NOTCH3 NOTCH4

1.10e-04115029187150
Pubmed

Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.

NOTCH3 NOTCH4

1.10e-041150212866128
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

DAB2IP CDCA2 KIF18A IGF2R MTUS1 ZFYVE16 PYCR2 DNAJC7

1.16e-04104950827880917
Pubmed

Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium.

NOTCH3 NOTCH4

1.32e-041250210952889
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

NOTCH3 NOTCH4

1.32e-041250215465494
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

DAB2IP IGF2R TENM3 ZFYVE16 DHX29 NOTCH3

1.55e-0456550625468996
Pubmed

A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.

NOTCH3 NOTCH4

1.56e-041350232929274
Pubmed

Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.

ERBB4 EFTUD2

1.56e-041350220858735
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

NOTCH3 NOTCH4

1.56e-041350211578869
Pubmed

Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.

NOTCH3 NOTCH4

1.56e-041350220558824
Pubmed

Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis.

NOTCH3 NOTCH4

1.82e-041450228192800
Pubmed

Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression.

ERBB4 NOTCH4

1.82e-041450221402699
Pubmed

Cell-fate transition and determination analysis of mouse male germ cells throughout development.

NOTCH3 NOTCH4

1.82e-041450234824237
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

NOTCH3 NOTCH4

1.82e-041450214757642
Pubmed

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

NOTCH3 NOTCH4

2.10e-041550214672936
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

NOTCH3 NOTCH4

2.10e-041550212971992
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

NOTCH3 NOTCH4

2.40e-041650212617809
Pubmed

Notch gene expression during pancreatic organogenesis.

NOTCH3 NOTCH4

2.40e-041650210842072
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

NOTCH3 NOTCH4

2.40e-041650217273555
Pubmed

Requirement of Math1 for secretory cell lineage commitment in the mouse intestine.

NOTCH3 NOTCH4

2.40e-041650211739954
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

NOTCH3 NOTCH4

2.72e-041750218694942
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

NOTCH3 NOTCH4

2.72e-041750215821257
Pubmed

Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking.

NOTCH3 NOTCH4

2.72e-041750239315665
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DAB2IP TENM3 ZFYVE16 ZNF451 CUL9

2.94e-0440750512693553
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

NOTCH3 NOTCH4

3.05e-041850218093989
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

NOTCH3 NOTCH4

3.05e-041850215689374
Pubmed

Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.

TENM3 H6PD

3.41e-041950214671302
Pubmed

Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.

NOTCH3 NOTCH4

3.41e-041950216518823
Pubmed

Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.

NOTCH3 NOTCH4

4.18e-042150228656980
Pubmed

Conversion of biliary system to pancreatic tissue in Hes1-deficient mice.

NOTCH3 NOTCH4

4.18e-042150214702043
Pubmed

E3 ubiquitin ligase FBXW7 balances airway cell fates.

NOTCH3 NOTCH4

4.59e-042250234998785
Pubmed

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.

NOTCH3 NOTCH4

5.03e-042350214701881
Pubmed

Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility.

NOTCH3 NOTCH4

5.03e-042350236239412
Pubmed

Rbpj regulates development of prosensory cells in the mammalian inner ear.

NOTCH3 NOTCH4

5.48e-042450221420948
Pubmed

Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.

CR2 NOTCH4

5.48e-042450211739537
Pubmed

A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.

CUL9 EFTUD2

5.48e-042450233705438
Pubmed

The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice.

NOTCH3 NOTCH4

5.95e-042550221786021
Pubmed

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning.

NOTCH3 NOTCH4

6.44e-042650225446530
Pubmed

Notch signaling controls liver development by regulating biliary differentiation.

NOTCH3 NOTCH4

6.44e-042650219369401
CytobandEnsembl 112 genes in cytogenetic band chr17q21

WFIKKN2 DNAJC7 PLEKHM1 EFTUD2

1.76e-03473504chr17q21
CytobandEnsembl 112 genes in cytogenetic band chr11p14

KIF18A LUZP2

1.98e-0360502chr11p14
Cytoband19q13.4

ZNF132 ZNF304

3.39e-037950219q13.4
Cytoband17q21.31

PLEKHM1 EFTUD2

3.65e-038250217q21.31
GeneFamilyWAP four-disulfide core domain containing|Fibronectin type III domain containing

WFIKKN2 WFDC5

5.78e-0418362361
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF132 HIC1 ZNF451 ZNF683 ZNF639 ZNF304

2.70e-0371836628
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 LUZP2 TAFA4 CNR1 IL9

1.63e-061775051cb78133ac09ea3a3f5b5de07151033998406512
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 LUZP2 TAFA4 CNR1 IL9

1.82e-061815052f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 LUZP2 TAFA4 CNR1 IL9

2.14e-0618750502105c82a9ba79d2f19e002188377fc3440770c2
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-MC4R|Neuronal / cells hierarchy compared to all cells using T-Statistic

ERBB4 LUZP2 TAFA4 CNR1 IL9

2.97e-06200505c1797542541747b524c9c22c723d24c8d027d486
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-MC4R-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

ERBB4 LUZP2 TAFA4 CNR1 IL9

2.97e-06200505a0cc84add181109bb66ba9d49c732e1790222c96
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HIC1 SLC16A14 CNR1 NOTCH3

3.05e-05159504cfb4a8c8aac34b1a857956d98382d487abcf5444
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HIC1 SLC16A14 CNR1 NOTCH3

3.05e-05159504a75ab494959575143cefdaec99e7aee3f318d559
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 LUZP2 TAFA4 CNR1

3.87e-051695046a2ef66d7ff69a92e8c62759482e823a07352440
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D175|Adult / Lineage, Cell type, age group and donor

NLRP11 MATN2 SLC16A14 NOTCH4

4.43e-051755040a65ddfa8c2e8efb5b5338cf07661cb78157a23c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 MTUS1 LUZP2 TAFA4

4.43e-0517550411f49f00e000cbc137e3540a6d6805cde21d96e6
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 TENM3 LUZP2 TAFA4

4.43e-05175504955f10982a487e12cdc3a9f80b3be06bf6c59de7
ToppCellILEUM-inflamed-(9)_Enteric_neurons|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ANK2 TENM3 MATN2 WFIKKN2

4.73e-05178504d9142151819afb0dc22bfb32a9c9dba5f553067d
ToppCellILEUM-inflamed-(9)_Neuro_cell|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ANK2 TENM3 MATN2 WFIKKN2

4.73e-05178504611504b0a9e6318b18fba83787b03f9245c82252
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 LUZP2 TAFA4 CNR1

4.94e-05180504b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 MTUS1 LUZP2 CNR1

5.05e-0518150435bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDCA2 MATN2 CXCL16 CFAP46

5.05e-05181504c26d3cbbc592299786d79d1b15fc6bead2aafb9a
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 MTUS1 LUZP2 CNR1

5.16e-051825043d7a8d2ee2137b098248597058974ef5ae09c19e
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SHROOM4 HIC1 MTUS1 NOTCH4

5.16e-05182504997d37ca2af661c92a56add888762724dfccc890
ToppCelltumor_Lymph_Node_/_Brain-Endothelial_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

SHROOM4 MATN2 CNR1 NOTCH4

5.16e-05182504d7cce5dd7046f06bf40f00c9dbfa610722b03333
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 TENM3 MTUS1 TAFA4

5.27e-0518350404d3cc76038b8192c915f1c08c3e26f2ad3b3779
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 TAFA4 CNR1 IL9

5.27e-051835046e6128c5be5e0a2db6d84eecbf4dddd02d0216f8
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 LUZP2 TAFA4 CNR1

5.27e-051835045e361be3ae3fe05098968e58427630127bd12675
ToppCellControl-T_cells-Cycling_NK/T_cells|Control / group, cell type (main and fine annotations)

CDCA2 KIF18A UHRF2 CR2

5.50e-051855049766216b41ee62bbac4caa25cb98ec5627a24075
ToppCellAnterior_Cingulate_gyrus_(CgG)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 TENM3 LUZP2 CNR1

5.61e-0518650432af3f211f9ad5d5c6b86b83325cfbf2f8466b56
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-proliferating_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SHROOM4 HIC1 MTUS1 NOTCH4

5.61e-05186504a844d4f79e0ad5d6c60a4488ffd8f4f21b7eed04
ToppCelltumor_Lymph_Node_/_Brain-Endothelial_cells-Tumor_ECs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

SHROOM4 MATN2 CNR1 NOTCH4

5.73e-05187504be5f8c5802b0fa8cc1e274fdf06b13eb8ceb8ad4
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 TENM3 MTUS1 TAFA4

5.85e-051885048de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IGF2R ANK2 MATN2 NOTCH3

6.10e-05190504106862ef44fcaa0971c3ba0147d13eb08015ca77
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 TENM3 MTUS1 TAFA4

6.10e-051905043f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 TENM3 MTUS1 TAFA4

6.10e-05190504305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 TENM3 MTUS1 TAFA4

6.10e-0519050439ab890104b4264c68a968f920f4ccd84f0bc681
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 TENM3 MTUS1 TAFA4

6.10e-05190504e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCell3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHROOM4 MTUS1 SLC16A14 NOTCH4

6.10e-05190504ec6b8e2852e1cce0217ff61243defe98b2351640
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SHROOM4 MTUS1 SLC16A14 NOTCH4

6.22e-0519150404c7aa2e39fdd08ca24c10d43b29a5e41a73b9e0
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SHROOM4 MTUS1 SLC16A14 NOTCH4

6.22e-05191504db8dd6bbba803585bdd6a55d5c403d383f2e9acf
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 TENM3 LUZP2 TAFA4

6.35e-051925040003d7ef9a8e521e70ac33c63aad843d9b6215c2
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SHROOM4 AMER2 MTUS1 ZFYVE16

6.61e-05194504cb0422e7607dbd77204428b7e2c70dfe14a6ca11
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK2 TENM3 MATN2 PYCR2

6.74e-05195504bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHROOM4 MTUS1 SLC16A14 NOTCH4

6.74e-05195504b0979c1b5e4576468b8fe4e9027650859e598b34
ToppCell15-Trachea-Epithelial-Epithelial|Trachea / Age, Tissue, Lineage and Cell class

AMER2 ANK2 MATN2 CNR1

6.74e-051955049e9283a397f56732a0a5f2e2527f154d4c2dd56a
ToppCell(7)_MNP-(7)_Macrophage|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)

SARM1 CUL9 CR2 NOTCH3

6.88e-0519650471ec157163278ad259c190051926bf41e4ecef46
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANK2 MTUS1 LUZP2 CNR1

7.01e-05197504b9478212f14b7888e3abac02995177974ac3bd17
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-tip_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SHROOM4 HIC1 MTUS1 NOTCH4

7.01e-05197504b212ff28ca2d1fea4140f186ab90941bdca21249
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal-GABAergic_neurons|GW09 / Sample Type, Dataset, Time_group, and Cell type.

ERBB4 CXCL16 NOTCH4 EFTUD2

7.01e-0519750421f3ef7c3c10b4e3adde431097dfdcd513c74a95
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SHROOM4 HIC1 MTUS1 NOTCH4

7.29e-051995041c69395c9305b6ecb0a826d46c8e8ec95795ad6d
ToppCelldistal-Endothelial-Artery-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DAB2IP MTUS1 MATN2 NOTCH4

7.29e-051995043788f3218356aaaa10684e48d63757037f8a3a3c
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-BAGE2|Neuronal / cells hierarchy compared to all cells using T-Statistic

ERBB4 LUZP2 TAFA4 CNR1

7.44e-0520050426f07d271e984f375145e4c10528fba44a5811e1
ToppCellTracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SHROOM4 MTUS1 NOTCH4 IMPG2

7.44e-052005045ec31c1be6bcc4124e1489d136570f3de33cc2e9
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-TYR-L2-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

ERBB4 MTUS1 LUZP2 CNR1

7.44e-0520050404954fbe1e2264077228bb582c9a5897a70e6da2
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-BAGE2-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

ERBB4 LUZP2 TAFA4 CNR1

7.44e-05200504c3637827ceba16b0d7956c280dd2ddbc8b1ba55e
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-TYR|Neuronal / cells hierarchy compared to all cells using T-Statistic

ERBB4 MTUS1 LUZP2 CNR1

7.44e-05200504bfdafb024a7b20d46837b2e6480dd4929253cd62
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST|Neuronal / cells hierarchy compared to all cells using T-Statistic

ERBB4 LUZP2 TAFA4 CNR1

7.44e-0520050453d5e427f0cbf5cf0b63efe4ec01da302f555704
DiseaseMalignant neoplasm of skin

ERBB4 NOTCH3 NOTCH4

1.01e-0459453C0007114
DiseaseSkin Neoplasms

ERBB4 NOTCH3 NOTCH4

1.01e-0459453C0037286
DiseaseBreast Carcinoma

HIC1 ERBB4 H6PD TAFA4 NOTCH3 NOTCH4

1.59e-04538456C0678222
DiseaseCarcinoma, Pancreatic Ductal

NOTCH3 NOTCH4

6.14e-0424452C0887833
DiseaseLiver carcinoma

CDCA2 KIF18A IGF2R MTUS1 NOTCH3

1.02e-03507455C2239176
Diseaseintestinal cancer (implicated_via_orthology)

ERBB4 NOTCH3

1.10e-0332452DOID:10155 (implicated_via_orthology)
DiseaseMalignant neoplasm of breast

HIC1 ERBB4 ANK2 H6PD TAFA4 NOTCH3 NOTCH4

1.12e-031074457C0006142
DiseaseMammary Carcinoma, Human

HIC1 H6PD TAFA4 NOTCH3 NOTCH4

1.19e-03525455C4704874
DiseaseMammary Neoplasms, Human

HIC1 H6PD TAFA4 NOTCH3 NOTCH4

1.19e-03525455C1257931
DiseaseMammary Neoplasms

HIC1 H6PD TAFA4 NOTCH3 NOTCH4

1.21e-03527455C1458155
Diseasetongue squamous cell carcinoma (is_marker_for)

ERBB4 MTUS1

1.46e-0337452DOID:0050865 (is_marker_for)
Diseasehip circumference

CDCA2 H6PD PLEKHM1 NOTCH4

1.74e-03338454EFO_0005093
DiseaseCutaneous Melanoma

ERBB4 CNR1

1.80e-0341452C0151779
Diseasehepatocellular carcinoma (is_implicated_in)

ERBB4 IGF2R EFTUD2

2.67e-03181453DOID:684 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
MCCPEVAKSCGHELL

C21orf140

156

B9A014
DPQCEKMEDGLLTCH

ERBB4

556

Q15303
ADMDLHCDCAAETPA

AMER2

41

Q8N7J2
AHLCRAQMCAPKSAE

CFAP46

86

Q8IYW2
QELMSCLDLKECGHA

CXCL16

91

Q9H2A7
EELCLHIMKCNLGSP

DHX29

1016

Q7Z478
TDQPKICDGHGCEAM

ANK2

2766

Q01484
AADLPEHQGNLKMCC

DAB2IP

461

Q5VWQ8
CALNKPGCEHECVNM

MATN2

406

O00339
DNGITPTKNLCHMDC

SPACA5

86

Q96QH8
DMHKDSICQCPALVG

MTUS1

96

Q9ULD2
DGMNILCDALLHPNC

NLRP11

761

P59045
SHLGLKPFACDACGM

HIC1

556

Q14526
SDNCLKMLCEVAIPH

KIF18A

741

Q8NI77
ACCPAKMILDNHDIS

KIAA2026

546

Q5HYC2
PMGKTGLLCHLDDAC

NOTCH3

341

Q9UM47
KMQEDPASKCHCSAN

IL9

36

P15248
CGDLNMHPEDLGCCL

SMPD2

176

O60906
HCKEVNCSSPADMDG

CR2

906

P20023
AACPQAHFMLKGDDD

B3GNT4

206

Q9C0J1
PLDNSMGDSDCLHKH

CNR1

421

P21554
NLPHTDFTLCKCMID

EIF3K

76

Q9UBQ5
ACDSQDEGRPCSMKH

LUZP2

281

Q86TE4
RLMPNSQKDCHCLGD

CDCA2

781

Q69YH5
ALRMAPDHEKACIAC

DNAJC7

236

Q99615
PLGCDDDLPSLCCMH

CUL9

2076

Q8IWT3
APIEKNEGCLHMTCA

CUL9

2241

Q8IWT3
CPKDMAPSHCAEHKD

H6PD

86

O95479
QCGPSSAVCMHDLKT

IGF2R

76

P11717
NGSKSPDHCEEPMSC

PLEKHM1

276

Q9Y4G2
HMNPCLEGEDCKVLP

TAFA4

106

Q96LR4
DTQLKPCGHSDLCMD

RSPRY1

536

Q96DX4
ECPDQAGHRKNMCAL

SLC16A14

266

Q7RTX9
LENSMCCKPLHCGDF

SHROOM4

866

Q9ULL8
LGAAKMLLDSEQHPC

PYCR2

211

Q96C36
LQPDFCLNDGKCDIM

IMPG2

1056

Q9BZV3
HLEDMCLSQPCHGDA

NOTCH4

391

Q99466
MAKNPPENCEDCHIL

TNMD

1

Q9H2S6
GGKHEPNMQLLCDEC

UHRF2

351

Q96PU4
PMNHLCHKDSDCSGK

WFDC5

91

Q8TCV5
CDMCGPFLKDILHLA

ZNF132

116

P52740
CPIMHCNKEFDNGHL

ZNF451

171

Q9Y4E5
ADLPHKCSDCLMRFG

ZNF639

456

Q9UID6
LSPGALDKCMQDHDC

SARM1

621

Q6SZW1
CEILKTMCPDQCSGH

TENM3

641

Q9P273
CHPSLERKDDNMGCA

TASOR2

1031

Q5VWN6
ESGLFQKAHPCEMCD

ZNF304

81

Q9HCX3
QKAHPCEMCDPLLKD

ZNF304

86

Q9HCX3
GHMDHLLPGCEDKNC

ITFG1

271

Q8TB96
SDCDPDGPLMCHTTK

EFTUD2

466

Q15029
MKEESAAQLGCCHRP

ZNF683

1

Q8IZ20
AKEIAMACSAALCPH

ZFYVE16

1451

Q7Z3T8
PKEATCDHFMCLQQG

WFIKKN2

106

Q8TEU8