Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A7	6.01e-05	3	90	2	GO:0008389
GeneOntologyMolecularFunction	cytoskeletal protein binding	MAGI1 INF2 MICAL2 CEP295NL SYNPO2L NUMA1 KLC2 MACF1 MICAL3 AIF1L TNS1 SMAD4 KIF22 DRG1 NOD2	1.10e-04	1099	90	15	GO:0008092
Domain	PDZ	MAGI1 ARHGAP23 PDZK1 SYNPO2L DLG2 PARD3 MAST3	4.25e-06	141	87	7	PF00595
Domain	PDZ	MAGI1 ARHGAP23 PDZK1 SYNPO2L DLG2 PARD3 MAST3	5.85e-06	148	87	7	SM00228
Domain	-	MAGI1 ARHGAP23 PDZK1 SYNPO2L DLG2 PARD3 MAST3	6.40e-06	150	87	7	2.30.42.10
Domain	PDZ	MAGI1 ARHGAP23 PDZK1 SYNPO2L DLG2 PARD3 MAST3	6.68e-06	151	87	7	PS50106
Domain	PDZ	MAGI1 ARHGAP23 PDZK1 SYNPO2L DLG2 PARD3 MAST3	6.98e-06	152	87	7	IPR001478
Domain	TPR_2	TOMM70 TTC7B KLC2 TTC3	8.59e-05	50	87	4	PF07719
Domain	TPR_2	TOMM70 TTC7B KLC2 TTC3	8.59e-05	50	87	4	IPR013105
Domain	ATP_Ca_trans_C	ATP2B1 ATP2B3	1.28e-04	4	87	2	IPR022141
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A6 CYP2A7	1.28e-04	4	87	2	IPR008067
Domain	ATP_Ca_trans_C	ATP2B1 ATP2B3	1.28e-04	4	87	2	PF12424
Domain	P-type_ATPase_IIB	ATP2B1 ATP2B3	1.28e-04	4	87	2	IPR006408
Domain	-	TXNRD1 MAOA MICAL2 MICAL3	1.34e-04	56	87	4	3.50.50.60
Domain	FAD/NAD-binding_dom	TXNRD1 MAOA MICAL2 MICAL3	1.44e-04	57	87	4	IPR023753
Domain	TF_AP2	TFAP2E TFAP2A	2.13e-04	5	87	2	IPR004979
Domain	TF_AP2_C	TFAP2E TFAP2A	2.13e-04	5	87	2	IPR013854
Domain	TF_AP-2	TFAP2E TFAP2A	2.13e-04	5	87	2	PF03299
Domain	FAD-bd	MICAL2 MICAL3	3.18e-04	6	87	2	IPR002938
Domain	FAD_binding_3	MICAL2 MICAL3	3.18e-04	6	87	2	PF01494
Domain	TPR_1	TOMM70 TTC7B KLC2 TTC3	8.27e-04	90	87	4	PF00515
Domain	TPR_1	TOMM70 TTC7B KLC2 TTC3	8.27e-04	90	87	4	IPR001440
Domain	TPR_REGION	TOMM70 TTC7B KLC2 DELE1 TTC3	1.04e-03	165	87	5	PS50293
Domain	TPR	TOMM70 TTC7B KLC2 DELE1 TTC3	1.04e-03	165	87	5	PS50005
Domain	CARD	CARD6 NOD2	2.47e-03	16	87	2	SM00114
Domain	-	ATP2B1 ATP2B3	2.47e-03	16	87	2	1.20.1110.10
Domain	Guanylate_kinase_CS	MAGI1 DLG2	2.47e-03	16	87	2	IPR020590
Domain	ATPase_P-typ_TM_dom	ATP2B1 ATP2B3	2.47e-03	16	87	2	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP2B1 ATP2B3	2.79e-03	17	87	2	IPR006068
Domain	Cation_ATPase_C	ATP2B1 ATP2B3	2.79e-03	17	87	2	PF00689
Domain	-	TOMM70 TTC7B KLC2 DELE1 TTC3	2.82e-03	207	87	5	1.25.40.10
Domain	TPR	TOMM70 TTC7B KLC2 TTC3	3.11e-03	129	87	4	SM00028
Domain	Cation_ATPase_N	ATP2B1 ATP2B3	3.13e-03	18	87	2	PF00690
Domain	Cation_ATPase_N	ATP2B1 ATP2B3	3.13e-03	18	87	2	SM00831
Domain	CH	MICAL2 MACF1 MICAL3	3.46e-03	65	87	3	SM00033
Domain	TPR_repeat	TOMM70 TTC7B KLC2 TTC3	3.47e-03	133	87	4	IPR019734
Domain	ATPase_P-typ_cation-transptr_N	ATP2B1 ATP2B3	3.48e-03	19	87	2	IPR004014
Domain	Pyr_redox_2	TXNRD1 MICAL2	3.48e-03	19	87	2	PF07992
Domain	CH	MICAL2 MACF1 MICAL3	4.27e-03	70	87	3	PF00307
Domain	-	MICAL2 MACF1 MICAL3	4.44e-03	71	87	3	1.10.418.10
Domain	TPR-like_helical_dom	TOMM70 TTC7B KLC2 DELE1 TTC3	4.67e-03	233	87	5	IPR011990
Domain	CH	MICAL2 MACF1 MICAL3	4.80e-03	73	87	3	PS50021
Domain	GUANYLATE_KINASE_2	MAGI1 DLG2	5.09e-03	23	87	2	PS50052
Domain	GUANYLATE_KINASE_1	MAGI1 DLG2	5.09e-03	23	87	2	PS00856
Domain	CH-domain	MICAL2 MACF1 MICAL3	5.18e-03	75	87	3	IPR001715
Domain	TPR-contain_dom	TOMM70 TTC7B KLC2 TTC3	5.31e-03	150	87	4	IPR013026
Domain	Guanylate_kin	MAGI1 DLG2	6.48e-03	26	87	2	PF00625
Domain	GK/Ca_channel_bsu	MAGI1 DLG2	6.48e-03	26	87	2	IPR008145
Domain	Guanylate_kin-like_dom	MAGI1 DLG2	6.48e-03	26	87	2	IPR008144
Domain	GuKc	MAGI1 DLG2	6.48e-03	26	87	2	SM00072
Domain	CARD	CARD6 NOD2	7.49e-03	28	87	2	PF00619
Domain	CARD	CARD6 NOD2	9.14e-03	31	87	2	IPR001315
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TOMM70 EIF4ENIF1 INTS2 TRIM26 MRM1 PDZK1 HMGXB4 AFG3L2 TOPBP1 MACF1 FBXO11 AIF1L PARD3 GRSF1 HEXIM1 KIF22 DRG1 RAD21	6.60e-08	1497	92	18	31527615
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	MAGI1 H1-10 THOC7 EIF4H INF2 MICAL2 AFG3L2 NUMA1 KLC2 FBXO11 DOT1L PARD3 TRIP12 HEXIM1 KIF22	9.43e-07	1247	92	15	27684187
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	H1-10 EIF4H INF2 PRCC AFG3L2 GHITM MACF1 ATM PARD3 TTC3 ATP2B1 GRSF1 CDKAL1 MAST3 DRG1 RAD21	1.68e-06	1487	92	16	33957083
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	MAGI1 PDZK1 SYNPO2L PARD3	2.25e-06	35	92	4	33864728
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	H1-10 TRIM26 NUMA1 TOPBP1 MACF1 FBXO11 TRIP12 GRSF1 KIF22 DRG1 RAD21	5.38e-06	759	92	11	35915203
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ZMYND19 INTS2 INF2 TRIM26 MACF1 FBXO11 DOT1L PARD3 TTC3 TRIP12 TNS1 ATP2B1 GRSF1	5.58e-06	1084	92	13	11544199
Pubmed	Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.	CYP2A6 CYP2A7	6.92e-06	2	92	2	12325023
Pubmed	CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.	CYP2A6 CYP2A7	6.92e-06	2	92	2	16636685
Pubmed	Regulation of mitochondrial proteostasis by the proton gradient.	AFG3L2 GHITM	6.92e-06	2	92	2	35912435
Pubmed	The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.	CYP2A6 CYP2A7	6.92e-06	2	92	2	2322567
Pubmed	Expression and alternative splicing of the cytochrome P-450 CYP2A7.	CYP2A6 CYP2A7	6.92e-06	2	92	2	7864805
Pubmed	Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms.	CYP2A6 EGLN2	6.92e-06	2	92	2	24045616
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	H1-10 THOC7 INTS2 HMGXB4 AFG3L2 NUMA1 TOPBP1 FBXO11 TRIP12 TFAP2A CDKAL1 SMAD4 KIF22 RAD21	7.62e-06	1294	92	14	30804502
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	TTC7B INF2 AFG3L2 MACF1 MICAL3 PARD3 ATP2B1 CDKAL1	1.65e-05	421	92	8	36976175
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A7	2.07e-05	3	92	2	31645370
Pubmed	Inhibition effects of Vernonia cinerea active compounds against cytochrome P450 2A6 and human monoamine oxidases, possible targets for reduction of tobacco dependence.	CYP2A6 MAOA	2.07e-05	3	92	2	25857233
Pubmed	CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	CYP2A6 CYP2A7	2.07e-05	3	92	2	11960914
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A7	2.07e-05	3	92	2	8297477
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A7	2.07e-05	3	92	2	8188299
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A7	2.07e-05	3	92	2	8250953
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A7	2.07e-05	3	92	2	2703500
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A7	2.07e-05	3	92	2	22217847
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A7	2.07e-05	3	92	2	22890016
Pubmed	Trafficking of presynaptic PMCA signaling complexes in mouse photoreceptors requires Cav1.4 α1 subunits.	CACNA1F ATP2B1	2.07e-05	3	92	2	22183401
Pubmed	Smad4-dependent morphogenic signals control the maturation and axonal targeting of basal vomeronasal sensory neurons to the accessory olfactory bulb.	TFAP2E SMAD4	2.07e-05	3	92	2	32341026
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A7	2.07e-05	3	92	2	3346244
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A7	2.07e-05	3	92	2	2733794
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A7	2.07e-05	3	92	2	8484736
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A7	2.07e-05	3	92	2	1417950
Pubmed	A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.	TOPBP1 ATM	2.07e-05	3	92	2	11756551
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A7	2.07e-05	3	92	2	24045421
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A7	2.07e-05	3	92	2	32987105
Pubmed	Divergent mechanisms underlie Smad4-mediated positive regulation of the three genes encoding the basement membrane component laminin-332 (laminin-5).	LAMA3 SMAD4	2.07e-05	3	92	2	18664273
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A7	2.07e-05	3	92	2	2765478
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A7	2.07e-05	3	92	2	2415518
Pubmed	CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.	CYP2A6 CYP2A7	2.07e-05	3	92	2	25710939
Pubmed	Tagging genes with cassette-exchange sites.	EIF4H MACF1 TRIP12 TNS1 CDKAL1 SMAD4 KIF22	3.14e-05	335	92	7	15741177
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	USP53 MAGI1 MAOA INTS2 GUCY1A1 INF2 MICAL2 TRIM26 LAMA3 MACF1 MICAL3 PARD3 TTC3 ATP2B1	3.61e-05	1489	92	14	28611215
Pubmed	Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump.	ATP2B1 ATP2B3	4.14e-05	4	92	2	18029012
Pubmed	Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling.	TOPBP1 ATM	4.14e-05	4	92	2	25301947
Pubmed	Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons.	ATP2B1 ATP2B3	4.14e-05	4	92	2	12209837
Pubmed	Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.	CYP2A6 CYP2A7	4.14e-05	4	92	2	10490589
Pubmed	Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta.	ATP2B1 ATP2B3	4.14e-05	4	92	2	12784250
Pubmed	Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice.	POMC IRS2	4.14e-05	4	92	2	22210743
Pubmed	Gene-gene interactions of CYP2A6 and MAOA polymorphisms on smoking behavior in Chinese male population.	CYP2A6 MAOA	4.14e-05	4	92	2	19415821
Pubmed	Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.	CYP2A6 CYP2A7	4.14e-05	4	92	2	1970547
Pubmed	The plasma membrane calcium pump in health and disease.	ATP2B1 ATP2B3	4.14e-05	4	92	2	23413890
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B1 ATP2B3	4.14e-05	4	92	2	8245032
Pubmed	NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis.	CARD6 NOD2	4.14e-05	4	92	2	26976200
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B1 ATP2B3	4.14e-05	4	92	2	7989379
Pubmed	Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.	ATP2B1 ATP2B3	4.14e-05	4	92	2	11152753
Pubmed	The MICAL proteins and rab1: a possible link to the cytoskeleton?	MICAL2 MICAL3	4.14e-05	4	92	2	15694364
Pubmed	PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†.	ATP2B1 ATP2B3	4.14e-05	4	92	2	36130203
Pubmed	Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse.	ATP2B1 ATP2B3	4.14e-05	4	92	2	10434059
Pubmed	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.	CYP2A6 CYP2A7	4.14e-05	4	92	2	9408084
Pubmed	Calcium pumps of plasma membrane and cell interior.	ATP2B1 ATP2B3	4.14e-05	4	92	2	15101689
Pubmed	Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability.	NUMA1 ATM	4.14e-05	4	92	2	25936915
Pubmed	Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function.	ATP2B1 ATP2B3	4.14e-05	4	92	2	10577388
Pubmed	Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.	MICAL2 MICAL3	4.14e-05	4	92	2	24440334
Pubmed	Structural organization, ion transport, and energy transduction of P-type ATPases.	ATP2B1 ATP2B3	4.14e-05	4	92	2	8634322
Pubmed	A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.	CYP2A6 CYP2A7	4.14e-05	4	92	2	7565685
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	MRM1 AFG3L2 NUMA1 KLC2 MICAL3 IRS2 ATM TRIP12	5.35e-05	497	92	8	36774506
Pubmed	MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.	MICAL2 MICAL3	6.89e-05	5	92	2	12110185
Pubmed	Do checkpoint kinases contribute to HIV-1-mediated apoptosis?	TOPBP1 ATM	6.89e-05	5	92	2	19164952
Pubmed	The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope.	TOPBP1 ATM	6.89e-05	5	92	2	19023333
Pubmed	Analysis of transcription factor AP-2 expression and function during mouse preimplantation development.	TFAP2E TFAP2A	6.89e-05	5	92	2	16672719
Pubmed	Pro-apoptotic function of checkpoint kinase-2 in syncytia elicited by the HIV-1 envelope.	TOPBP1 ATM	6.89e-05	5	92	2	19177012
Pubmed	Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue.	MAOA POMC	6.89e-05	5	92	2	16610949
Pubmed	Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1).	TOPBP1 ATM	6.89e-05	5	92	2	21502314
Pubmed	CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents.	CYP2A6 MAOA	6.89e-05	5	92	2	16272956
Pubmed	Differential regulation of the apical plasma membrane Ca(2+) -ATPase by protein kinase A in parotid acinar cells.	ATP2B1 ATP2B3	6.89e-05	5	92	2	17938178
Pubmed	AP-2α and AP-2β regulate dorsal interneuron specification in the spinal cord.	TFAP2E TFAP2A	6.89e-05	5	92	2	27984181
Pubmed	SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex.	NUMA1 PARD3	6.89e-05	5	92	2	26766442
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	TOMM70 EIF4H GHITM FBXO11 ATP2B1 RAD21	8.62e-05	271	92	6	25737280
Pubmed	A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.	KLC2 IRS2 PARD3 MAST3	8.63e-05	87	92	4	17979178
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	TOMM70 ZNF536 HMGXB4 FBXO11 TRIP12 ATP2B1 ATP2B3 TFAP2A SMAD4 KIF22	9.13e-05	857	92	10	25609649
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	TOMM70 TTC7B ARHGAP23 INF2 MICAL2 AFG3L2 KLC2 MACF1 DLG2 MICAL3 TNS1 ATP2B1 ATP2B3	9.96e-05	1431	92	13	37142655
Pubmed	A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.	CYP2A6 CYP2A7	1.03e-04	6	92	2	7668294
Pubmed	Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults.	CYP2A6 MAOA	1.03e-04	6	92	2	18188752
Pubmed	Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange.	ATP2B1 ATP2B3	1.03e-04	6	92	2	12767889
Pubmed	Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy.	ATM RAD21	1.03e-04	6	92	2	18829510
Pubmed	Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.	CYP2A6 CYP2A7	1.03e-04	6	92	2	8587134
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	MAGI1 AFG3L2 NUMA1 MACF1 MICAL3 IRS2 PARD3 ATP2B1 CDKAL1	1.10e-04	708	92	9	39231216
Pubmed	Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.	MAGI1 PDZK1 DLG2	1.20e-04	36	92	3	26053890
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	MAGI1 H1-10 EIF4H ARHGAP23 KLC2 MACF1 PARD3 ATP2B1	1.30e-04	565	92	8	25468996
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1F ATP2B1 ATP2B3	1.41e-04	38	92	3	30786075
Pubmed	Direct cDNA selection with DNA microdissected from mouse chromosome 16: isolation of novel clones and construction of a partial transcription map of the C3-C4 region.	TOMM70 TTC3	1.44e-04	7	92	2	8858343
Pubmed	Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.	CYP2A6 CYP2A7	1.44e-04	7	92	2	9630227
Pubmed	Genome-wide analysis of H4K5 acetylation associated with fear memory in mice.	EIF4ENIF1 DRG1	1.44e-04	7	92	2	23927422
Pubmed	Robust control of mitotic spindle orientation in the developing epidermis.	NUMA1 PARD3	1.44e-04	7	92	2	21098114
Pubmed	Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.	CYP2A6 CYP2A7	1.44e-04	7	92	2	14630516
Pubmed	Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb.	TFAP2E TFAP2A	1.44e-04	7	92	2	14572467
Pubmed	AP-2ε Expression in Developing Retina: Contributing to the Molecular Diversity of Amacrine Cells.	TFAP2E TFAP2A	1.44e-04	7	92	2	29467543
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	MAGI1 KLC2 IRS2 PARD3	1.60e-04	102	92	4	15778465
Pubmed	Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.	LAMA3 PARD3 SMAD4	1.65e-04	40	92	3	27068110
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	H1-10 ZNF536 EIF4ENIF1 ARHGAP23 HMGXB4 AFG3L2 MACF1 IRS2 PARD3 CDKAL1 DRG1	1.77e-04	1116	92	11	31753913
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	AFG3L2 MACF1 DLG2 MICAL3 FAM81A	1.83e-04	197	92	5	36604605
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	MAGI1 EIF4ENIF1 IFFO1 KLC2 IRS2 PARD3 RAD21	1.87e-04	446	92	7	24255178
Pubmed	Genome-wide meta-analyses identify multiple loci associated with smoking behavior.	CYP2A6 EGLN2	1.92e-04	8	92	2	20418890
Pubmed	Gene knockout studies of Ca2+-transporting ATPases.	ATP2B1 ATP2B3	1.92e-04	8	92	2	10951186
GeneFamily	PDZ domain containing	MAGI1 ARHGAP23 PDZK1 SYNPO2L DLG2 PARD3 MAST3	1.33e-06	152	66	7	1220
GeneFamily	ATPases Ca2+ transporting	ATP2B1 ATP2B3	4.65e-04	9	66	2	1209
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TOMM70 TTC7B KLC2 TTC3	8.26e-04	115	66	4	769
Coexpression	GSE17721_0.5H_VS_8H_PAM3CSK4_BMDC_UP	ARHGAP23 MICAL2 FFAR2 LAMA3 ATM TNS1 SMAD4	6.87e-06	200	92	7	M4110
ToppCell	Striatum-Neuronal-Excitatory\|Striatum / BrainAtlas - Mouse McCarroll V32	TOMM70 JPH4 ARPP21 KCNS2 ATP2B1 MAST3	3.31e-06	196	92	6	67400193ba469cf4d939e94f5ed94995e384bc07
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF536 LAMA3 IGDCC3 PODN PARD3	3.69e-05	181	92	5	154d5e586cab25155c6d06dfe6ae01203b88e0fb
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIGB THOC7 FFAR2 MAST3 PHTF1	3.79e-05	182	92	5	d486b0213bd3cf20965cb4e38e95981c4aaff259
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI1 GUCY1A1 LAMA3 DLG2 PARD3	3.89e-05	183	92	5	6847c1252d6bb105524f812658112517fd351eab
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MAGI1 MICAL2 LAMA3 PARD3 TNS1	3.99e-05	184	92	5	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MAGI1 MICAL2 LAMA3 PARD3 TNS1	3.99e-05	184	92	5	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ARPP21 INF2 ATP2B1 FAM81A MAST3	4.21e-05	186	92	5	56c139e679d640ea901ead657a8e8887e0fca098
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MAGI1 MICAL2 LAMA3 DOT1L PARD3	4.42e-05	188	92	5	43a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Striatum / BrainAtlas - Mouse McCarroll V32	TOMM70 JPH4 ARPP21 ATP2B1 MAST3	4.42e-05	188	92	5	e34ea7014c5a059a7db38f78bd903cf02616ddd3
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI1 MICAL2 LAMA3 PARD3 TNS1	4.65e-05	190	92	5	30b50d183d7649146eb1e79b47ba897355f1998a
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI1 MICAL2 LAMA3 DLG2 PARD3	4.77e-05	191	92	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	Control-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	MAGI1 MAOA MICAL2 DLG2 PARD3	4.89e-05	192	92	5	1bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI1 MACF1 DLG2 PARD3 CDKAL1	4.89e-05	192	92	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MAGI1 MICAL2 LAMA3 DLG2 PARD3	5.14e-05	194	92	5	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAGI1 MICAL2 LAMA3 DLG2 PARD3	5.14e-05	194	92	5	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MAGI1 MICAL2 LAMA3 DLG2 PARD3	5.26e-05	195	92	5	9406866f99555198a9be311fbd65751b70f35446
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF536 DLG2 AIF1L TFAP2A KIF22	5.39e-05	196	92	5	4924a36a81d62863c1004b8c76f8096a1f89c548
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF536 DLG2 AIF1L TFAP2A KIF22	5.66e-05	198	92	5	a11ac83dbd69d1c068971266d7c7343d114a6294
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	JPH4 ARPP21 DLG2 TTC3 ATP2B1	5.79e-05	199	92	5	058373b4ac3cec2108cb24265628ff0a50646e33
Disease	Hailey-Hailey disease (implicated_via_orthology)	ATP2B1 ATP2B3	1.28e-04	6	87	2	DOID:0050429 (implicated_via_orthology)
Disease	Adenoid Cystic Carcinoma	MAGI1 GUCY1A1 PDZK1 ATM	2.23e-04	100	87	4	C0010606
Disease	Liver Diseases, Parasitic	CYP2A6 SMAD4	3.05e-04	9	87	2	C0023897
Disease	familial Mediterranean fever (is_implicated_in)	POMC NOD2	3.05e-04	9	87	2	DOID:2987 (is_implicated_in)
Disease	sleep disorder (implicated_via_orthology)	TFAP2E TFAP2A	4.65e-04	11	87	2	DOID:535 (implicated_via_orthology)
Disease	Bipolar Disorder	MAGI1 MAOA HMGXB4 POMC DLG2 GDNF NOD2	5.30e-04	477	87	7	C0005586
Disease	nicotine metabolite ratio	CYP2A6 CYP2A7	5.56e-04	12	87	2	EFO_0007794
Disease	Prenatal Exposure Delayed Effects	MAOA ATM	5.56e-04	12	87	2	C0033054
Disease	Behavior Disorders	MAOA POMC	5.56e-04	12	87	2	C0004930
Disease	Mental disorders	MAOA POMC	5.56e-04	12	87	2	C0004936
Disease	Huntington Disease, Late Onset	MAOA GDNF	5.56e-04	12	87	2	C0393574
Disease	TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)	CYP2A6 EGLN2	5.56e-04	12	87	2	C1861063
Disease	Mental Disorders, Severe	MAOA POMC	5.56e-04	12	87	2	C4046029
Disease	Akinetic-Rigid Variant of Huntington Disease	MAOA GDNF	5.56e-04	12	87	2	C0751207
Disease	Juvenile Huntington Disease	MAOA GDNF	5.56e-04	12	87	2	C0751208
Disease	Diagnosis, Psychiatric	MAOA POMC	5.56e-04	12	87	2	C0376338
Disease	neutrophil count	USP53 MAGI1 THOC7 ARHGAP23 SNX32 PRCC MICAL2 FFAR2 HSPA7 CDKAL1 PHTF1 DRG1	7.30e-04	1382	87	12	EFO_0004833
Disease	Body Weight	POMC CDKAL1	8.80e-04	15	87	2	C0005910
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	ZNF536 PRCC POMC ATM	9.79e-04	148	87	4	C0279702
Disease	Pheochromocytoma, Extra-Adrenal	MAOA GDNF	1.00e-03	16	87	2	C1257877
Disease	succinylcarnitine measurement	ZNF536 CRAT	1.00e-03	16	87	2	EFO_0020020
Disease	MAJOR AFFECTIVE DISORDER 2	MAGI1 HMGXB4	1.14e-03	17	87	2	C1839839
Disease	pre-malignant neoplasm (biomarker_via_orthology)	ATM SMAD4	1.14e-03	17	87	2	DOID:0060071 (biomarker_via_orthology)
Disease	Huntington Disease	MAOA GDNF	1.14e-03	17	87	2	C0020179
Disease	caffeine metabolite measurement	CYP2A6 CYP2A7	1.42e-03	19	87	2	EFO_0007872
Disease	leukemia (implicated_via_orthology)	ATM DOT1L	1.42e-03	19	87	2	DOID:1240 (implicated_via_orthology)
Disease	Pheochromocytoma	MAOA GDNF	1.42e-03	19	87	2	C0031511
Disease	cigarettes per day measurement	MAGI1 CYP2A6 CYP2A7 EGLN2 ZNF536 SMAD4	1.90e-03	438	87	6	EFO_0006525
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	EGLN2 GDNF	2.09e-03	23	87	2	C1708353
Disease	smoking status measurement, chronic obstructive pulmonary disease	TRIM26 MICAL3 TNS1	2.27e-03	88	87	3	EFO_0000341, EFO_0006527
Disease	Pseudoaphakia	ATM ATP2B1	2.27e-03	24	87	2	C0524524
Disease	Lens Opacities	ATM ATP2B1	2.27e-03	24	87	2	C1510497
Disease	Hypertensive disease	GUCY1A1 POMC ATP2B1 ATP2B3	2.44e-03	190	87	4	C0020538
Disease	nevus count, cutaneous melanoma	TTC7B ATM CDKAL1	2.49e-03	91	87	3	EFO_0000389, EFO_0004632
Disease	age-related hearing impairment	MAGI1 ZNF536 EIF4ENIF1 DLG2 DRG1	2.74e-03	324	87	5	EFO_0005782
Disease	hypertension, COVID-19	GUCY1A1 ATP2B1	2.88e-03	27	87	2	EFO_0000537, MONDO_0100096
Disease	Adenocarcinoma of large intestine	ATM SMAD4 RAD21	2.90e-03	96	87	3	C1319315

Protein segments in the cluster

Peptide	Gene	Start	Entry
GGKAFGLLKARQERR	AIF1L	11	Q9BQI0
RGKGDLALQRRADAK	CEP295NL	86	Q96MC4
RRKRIVGGKRAQLGD	CFI	336	P05156
NRRGLDLLTAEKGGL	nan	456	Q9N2K0
RDFGVGKRGIEERIQ	CYP2A6	136	P11509
IDEIDAVGRKRGRGN	AFG3L2	406	Q9Y4W6
GGRSLREKLDKIGLN	TFAP2A	261	P05549
SGGVGERLQKGLERR	CRAT	76	P43155
RQLDGLAGLKGEGSR	DOT1L	1371	Q8TEK3
REGGILTDSFGRIKR	CCM2L	491	Q9NUG4
GKDFNRRIRNEKGEI	ATP2B1	736	P20020
KKRQLFRGNRDGSGR	ARPP21	326	Q9UBL0
LEGKEFNRRIRNEKG	ATP2B3	731	Q16720
KNGGRCLRERLEKIG	TFAP2E	266	Q6VUC0
LRKGHQLDGTRRGDN	ADIPOR2	21	Q86V24
LRKRRKGGEADNLDE	RAD21	401	O60216
QNKGGGDRLARLFLE	FAM81A	66	Q8TBF8
GIHFLLNRDGKRRGD	GRSF1	181	Q12849
DLGLEVGKLAARGAR	PCDHB1	51	Q9Y5F3
KAGLQDGDRVLRING	PDZK1	46	Q5T2W1
LNIARGKEDGEKTRR	ANKRD36C	836	Q5JPF3
AGERAAREVLNGLGK	MAOA	451	P21397
FRRRKEKGLLGNDAA	CACNA1F	1596	O60840
GNLEFGDISKDRGRL	PODN	581	Q7Z5L7
FQDDGGLGRPKRERR	CT55	246	Q8WUE5
LRVDIAEGRKQDKGG	EIF4H	111	Q15056
GGDGRRNTLEGFRRK	MICAL3	221	Q7RTP6
LRNQGSSLLGRRGKD	FFAR2	291	O15552
GARRGQRGQLGRDEK	IGDCC3	696	Q8IVU1
RGGSRSAERKGDLQR	MED14OS	96	P0DP75
NGGRRVRLFLKRGDG	MAGI1	1221	Q96QZ7
KDGKGRGRQVIAVAR	DRG1	126	Q9Y295
DGEKGRLVVDGLRAR	LAMA3	3076	Q16787
IGIRRGRTGQELKEA	GHITM	51	Q9H3K2
LNRKKLEGGGERRGA	H1-10	116	Q92522
QQGKREGLGVERKSR	JPH4	66	Q96JJ6
NRLRLESKRLGGDDA	HEXIM1	306	O94992
AGSEDNRRTGNKGLR	KIF22	276	Q14807
NRRTGNKGLRLKESG	KIF22	281	Q14807
KNGERQDEESLGGRR	INTS2	231	Q9H0H0
DGEIRINVGGFKRRL	KCNS2	16	Q9ULS6
FKRELTGQRLREGDG	POMC	176	P01189
ENSRGKGRRGQRGKN	GDNF	101	P39905
DIGLAAGRSQREKKR	HMGXB4	21	Q9UGU5
EVKGALRRLLGKGRE	OR2C1	296	O95371
RKGFQLRKTARGRGD	INF2	981	Q27J81
GLDRRGAGKRNVLIF	HSPA7	186	P48741
LKRRGEELIGRSQGA	MACF1	5951	Q9UPN3
VVELLKDGSGRRGDR	KLC2	491	Q9H0B6
EGKQGRRGLGRRDQA	IFFO1	111	Q0D2I5
GDAAQDLDRGLRKRT	IRS2	561	Q9Y4H2
GSDGKERRQLVKGRD	ATM	2706	Q13315
TGQEKGRAEGRQARK	LINC00482	176	Q8N8I6
ERGDAGDRRKNMEGL	CARD6	611	Q9BX69
ILKGEKGDRGDRGLQ	C1QTNF1	96	Q9BXJ1
TLRRNKIHDGRDGGI	FBXO11	721	Q86XK2
QKKDNGRRLGGARLD	CDKAL1	181	Q5VV42
RDFGVGKRGIEERIQ	CYP2A7	136	P20853
KLGTGERLDGEAGRR	MAST3	1226	O60307
GAAQKDGRLQVGDRL	DLG2	231	Q15700
EALKRGGRLRDGQLV	EGLN2	211	Q96KS0
EKGLGVQRNLGEALR	DELE1	396	Q14154
GADGRRNTLEGFRRK	MICAL2	221	O94851
LRNGEVKGALRRALG	OR2A1;	291	Q8NGT9
RAGRKGLEARLQQLG	NUMA1	761	Q14980
RGAAIQDGRLKAGDR	PARD3	496	Q8TEW0
QEKSARRRGDLLGEN	PIGB	46	Q92521
GRGGELFAKRQSRAD	SYNPO2L	756	Q9H987
DEAFKRLQGKRNRGR	PRCC	391	Q92733
AGKAGLQGKRAELLR	MRM1	76	Q6IN84
RTLDGRLQVAGRKGF	SMAD4	76	Q13485
GFREKTGALRKALRG	OVCA2	21	Q8WZ82
EKDSDGLRLLGGRRI	EIF4ENIF1	141	Q9NRA8
LEKGQRKDLGRHRDL	USP53	466	Q70EK8
ELQTKGKNGDGRRRS	TXNRD1	16	Q16881
ANSRGTEKRRVLLGG	TIGD3	201	Q6B0B8
FDKNRGRGSGRLLHE	ZMYND19	56	Q96E35
EERLARKAARGLNVG	NOD2	751	Q9HC29
DNKRKSRELNGGVDG	RNF19A	76	Q9NV58
GEKCRREAFRRLGNG	PHTF1	256	Q9UMS5
RAGLRTGDRLVKVNG	ARHGAP23	111	Q9P227
DRLLSGFGLEREKQG	TNS1	441	Q9HBL0
GKKESGQLRFGGRDR	SNRNP35	146	Q16560
LRTGQFRNALGDGKR	TTC3	276	P53804
REARGRGDASGLKRN	TOMM70	66	O94826
RKRLLIDGDGAGDDR	THOC7	11	Q6I9Y2
LRRDRDKIQGFQAKG	TRIM26	156	Q12899
KLGNLGKGRGRVREE	ZNF536	181	O15090
GAETRLRNGRRAGVK	ZNF252P-AS1	146	Q0IIN9
KEQIREKLSRGDGGR	ZNF547	126	Q8IVP9
KNGNLTRGVGRFREL	TTC7B	231	Q86TV6
DLSVRGKNRKELLGG	SNX32	166	Q86XE0
GLGKRGAAEARRQEK	TRIP12	341	Q14669
GRKLDKLRRLINSGG	TOPBP1	371	Q92547
RRLDQSGRDGGAVAK	nan	66	Q8NAQ8
GEQARAQDGLKKRLG	GUCY1A1	416	Q02108