Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cAMP-dependent protein kinase activity	PRKACA PRKACB	1.18e-04	7	48	2	GO:0004691
GeneOntologyMolecularFunction	cyclic nucleotide-dependent protein kinase activity	PRKACA PRKACB	2.02e-04	9	48	2	GO:0004690
GeneOntologyMolecularFunction	AMP-activated protein kinase activity	PRKACA PRKACB	2.52e-04	10	48	2	GO:0004679
GeneOntologyMolecularFunction	sodium ion binding	SCN2A SCN3A	5.06e-04	14	48	2	GO:0031402
GeneOntologyBiologicalProcess	negative regulation of meiotic cell cycle	NPR2 PRKACA PRKACB	2.31e-05	24	48	3	GO:0051447
GeneOntologyCellularComponent	cAMP-dependent protein kinase complex	PRKACA PRKACB	2.39e-04	10	49	2	GO:0005952
HumanPheno	Hypodontia	CACNA1B LEMD3 SCN3A PRKACA PRKACB WNT10A DALRD3	1.07e-05	229	19	7	HP:0000668
Domain	IQ	SCN2A SCN3A OBSCN CAMTA1	5.52e-05	81	48	4	SM00015
Domain	IQ_motif_EF-hand-BS	SCN2A SCN3A OBSCN CAMTA1	8.34e-05	90	48	4	IPR000048
Domain	IQ	SCN2A SCN3A OBSCN CAMTA1	9.48e-05	93	48	4	PS50096
Domain	Na_trans_cytopl	SCN2A SCN3A	9.64e-05	6	48	2	PF11933
Domain	Na_trans_cytopl	SCN2A SCN3A	9.64e-05	6	48	2	IPR024583
Domain	ZnF_C2H2	ZNF526 ZNF878 ZSCAN10 ZSCAN30 ZNF837 ZNF398 KLF15 ZNF275 DHX34	1.86e-04	808	48	9	SM00355
Domain	Na_channel_asu	SCN2A SCN3A	2.87e-04	10	48	2	IPR001696
Domain	Na_trans_assoc	SCN2A SCN3A	2.87e-04	10	48	2	IPR010526
Domain	Na_trans_assoc	SCN2A SCN3A	2.87e-04	10	48	2	PF06512
Domain	zf-C2H2	ZNF526 ZNF878 ZSCAN10 ZSCAN30 ZNF837 ZNF398 KLF15 ZNF275	3.50e-04	693	48	8	PF00096
Domain	Channel_four-helix_dom	CACNA1B SCN2A SCN3A	4.23e-04	57	48	3	IPR027359
Domain	-	CACNA1B SCN2A SCN3A	4.23e-04	57	48	3	1.20.120.350
Domain	ZINC_FINGER_C2H2_2	ZNF526 ZNF878 ZSCAN10 ZSCAN30 ZNF837 ZNF398 KLF15 ZNF275	7.33e-04	775	48	8	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF526 ZNF878 ZSCAN10 ZSCAN30 ZNF837 ZNF398 KLF15 ZNF275	7.46e-04	777	48	8	PS00028
Domain	IQ	SCN3A OBSCN CAMTA1	8.05e-04	71	48	3	PF00612
Domain	Znf_C2H2-like	ZNF526 ZNF878 ZSCAN10 ZSCAN30 ZNF837 ZNF398 KLF15 DHX34	8.73e-04	796	48	8	IPR015880
Domain	Znf_C2H2	ZNF526 ZNF878 ZSCAN10 ZSCAN30 ZNF837 ZNF398 KLF15 ZNF275	9.39e-04	805	48	8	IPR007087
Domain	-	ZNF526 ZNF878 ZSCAN10 ZSCAN30 ZNF837 ZNF398 KLF15	1.64e-03	679	48	7	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF526 ZNF878 ZSCAN10 ZSCAN30 ZNF837 ZNF398 KLF15	1.85e-03	694	48	7	IPR013087
Domain	Ion_trans_dom	CACNA1B SCN2A SCN3A	3.14e-03	114	48	3	IPR005821
Domain	Ion_trans	CACNA1B SCN2A SCN3A	3.14e-03	114	48	3	PF00520
Domain	-	CNNM2 PNPLA6	6.77e-03	48	48	2	2.60.120.10
Domain	RmlC-like_jellyroll	CNNM2 PNPLA6	7.61e-03	51	48	2	IPR014710
Domain	Prot_kinase_dom	TYK2 NPR2 PRKACA PRKACB OBSCN	8.18e-03	489	48	5	IPR000719
Domain	PROTEIN_KINASE_DOM	TYK2 NPR2 PRKACA PRKACB OBSCN	8.45e-03	493	48	5	PS50011
Domain	zf-C2H2_6	ZNF526 ZNF878 ZSCAN10 ZSCAN30	8.53e-03	314	48	4	PF13912
Domain	SCAN	ZSCAN10 ZSCAN30	9.12e-03	56	48	2	SM00431
Domain	AGC-kinase_C	PRKACA PRKACB	9.12e-03	56	48	2	IPR000961
Domain	AGC_KINASE_CTER	PRKACA PRKACB	9.12e-03	56	48	2	PS51285
Domain	S_TK_X	PRKACA PRKACB	9.12e-03	56	48	2	SM00133
Domain	SCAN_BOX	ZSCAN10 ZSCAN30	9.76e-03	58	48	2	PS50804
Domain	SCAN	ZSCAN10 ZSCAN30	9.76e-03	58	48	2	PF02023
Domain	SCAN_dom	ZSCAN10 ZSCAN30	9.76e-03	58	48	2	IPR003309
Domain	Retrov_capsid_C	ZSCAN10 ZSCAN30	1.01e-02	59	48	2	IPR008916
Domain	DH_1	ARHGEF40 OBSCN	1.14e-02	63	48	2	PS00741
Domain	Kinase-like_dom	TYK2 NPR2 PRKACA PRKACB OBSCN	1.24e-02	542	48	5	IPR011009
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	CACNA1B ADRB1 CHP2 PRKACA PRKACB	4.63e-05	178	32	5	M2890
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS	PRKACA PRKACB	4.97e-05	5	32	2	M26988
Pathway	WP_CARDIOMYOCYTE_SIGNALING_CONVERGING_ON_TITIN	ADRB1 PRKACA PRKACB	5.53e-05	33	32	3	M48071
Pathway	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION	PRKACA PRKACB	7.45e-05	6	32	2	MM14628
Pathway	KEGG_MEDICUS_REFERENCE_PKA_HOLOENZYME	PRKACA PRKACB	1.04e-04	7	32	2	M47896
Pathway	REACTOME_HDL_ASSEMBLY	PRKACA PRKACB	1.04e-04	7	32	2	MM15560
Pathway	REACTOME_HDL_ASSEMBLY	PRKACA PRKACB	1.39e-04	8	32	2	M27840
Pathway	REACTOME_ROBO_RECEPTORS_BIND_AKAP5	PRKACA PRKACB	1.78e-04	9	32	2	M27877
Pathway	REACTOME_CARDIAC_CONDUCTION	NPR2 SCN2A SCN3A PRKACA	2.03e-04	130	32	4	M27454
Pathway	KEGG_TASTE_TRANSDUCTION	CACNA1B PRKACA PRKACB	2.18e-04	52	32	3	M5785
Pathway	KEGG_MEDICUS_REFERENCE_AVP_V2R_PKA_SIGNALING_PATHWAY	PRKACA PRKACB	2.22e-04	10	32	2	M47648
Pathway	KEGG_HEDGEHOG_SIGNALING_PATHWAY	PRKACA PRKACB WNT10A	2.71e-04	56	32	3	M1053
Pathway	REACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM	PRKACA PRKACB	3.25e-04	12	32	2	M27950
Pathway	REACTOME_CREB1_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_ADENYLATE_CYCLASE	PRKACA PRKACB	3.25e-04	12	32	2	M27363
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1B ADRB1 PRKACA PRKACB	3.60e-04	151	32	4	M39329
Pathway	KEGG_WNT_SIGNALING_PATHWAY	CHP2 PRKACA PRKACB WNT10A	3.60e-04	151	32	4	M19428
Pathway	WP_DOPAMINE_METABOLISM	PRKACA PRKACB	3.83e-04	13	32	2	M39622
Pathway	REACTOME_RAP1_SIGNALLING	PRKACA PRKACB	5.15e-04	15	32	2	MM15019
Pathway	KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY	PRKACA PRKACB	5.15e-04	15	32	2	M47794
Pathway	REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS	PRKACA PRKACB	5.15e-04	15	32	2	MM15103
Pathway	KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY	PRKACA PRKACB	5.15e-04	15	32	2	M47504
Pathway	KEGG_LONG_TERM_POTENTIATION	CHP2 PRKACA PRKACB	5.25e-04	70	32	3	M3115
Pathway	KEGG_MEDICUS_REFERENCE_DRD1_GNAS_AC_PKA_SIGNALING_PATHWAY	PRKACA PRKACB	5.87e-04	16	32	2	M47551
Pathway	KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY	PRKACA PRKACB	5.87e-04	16	32	2	M47645
Pathway	REACTOME_DARPP_32_EVENTS	PRKACA PRKACB	5.87e-04	16	32	2	MM14699
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	PRKACA PRKACB	5.87e-04	16	32	2	M47650
Pathway	REACTOME_RAP1_SIGNALLING	PRKACA PRKACB	5.87e-04	16	32	2	M923
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	PRKACA PRKACB	5.87e-04	16	32	2	MM14492
Pathway	REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING	PRKACA PRKACB	6.65e-04	17	32	2	M26995
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	PRKACA PRKACB	6.65e-04	17	32	2	M47544
Pathway	REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY	PRKACA PRKACB	6.65e-04	17	32	2	MM15561
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	PRKACA PRKACB	6.65e-04	17	32	2	MM15215
Pathway	REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY	PRKACA PRKACB	8.33e-04	19	32	2	M27841
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	PRKACA PRKACB	9.25e-04	20	32	2	M759
Pathway	REACTOME_GLUCOSE_METABOLISM	POM121 PRKACA PRKACB	9.25e-04	85	32	3	M1870
Pathway	KEGG_APOPTOSIS	CHP2 PRKACA PRKACB	9.89e-04	87	32	3	M8492
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	PRKACA PRKACB	1.02e-03	21	32	2	M27485
Pathway	KEGG_GAP_JUNCTION	ADRB1 PRKACA PRKACB	1.09e-03	90	32	3	M4013
Pathway	KEGG_DILATED_CARDIOMYOPATHY	ADRB1 PRKACA PRKACB	1.09e-03	90	32	3	M835
Pathway	REACTOME_MUSCLE_CONTRACTION	NPR2 SCN2A SCN3A PRKACA	1.09e-03	203	32	4	M5485
Pathway	REACTOME_TRIGLYCERIDE_CATABOLISM	PRKACA PRKACB	1.34e-03	24	32	2	M10064
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	PRKACA PRKACB	1.34e-03	24	32	2	M47520
Pathway	REACTOME_DARPP_32_EVENTS	PRKACA PRKACB	1.34e-03	24	32	2	M751
Pathway	KEGG_MELANOGENESIS	PRKACA PRKACB WNT10A	1.52e-03	101	32	3	M7761
Pathway	PID_IL3_PATHWAY	PRKACA PRKACB	1.57e-03	26	32	2	M182
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAI_AC_PKA_SIGNALING_PATHWAY	PRKACA PRKACB	1.57e-03	26	32	2	M47553
Pathway	REACTOME_CA_DEPENDENT_EVENTS	PRKACA PRKACB	1.57e-03	26	32	2	MM14495
Pathway	KEGG_MEDICUS_REFERENCE_CRHR_PKA_ACTH_SIGNALING_PATHWAY	PRKACA PRKACB	1.69e-03	27	32	2	M47518
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_RASD1_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	PRKACA PRKACB	1.69e-03	27	32	2	M47519
Pathway	REACTOME_GPER1_SIGNALING	PRKACA PRKACB	1.69e-03	27	32	2	MM15664
Pathway	KEGG_MEDICUS_REFERENCE_GHRHR_PKA_GH_SIGNALING_PATHWAY	PRKACA PRKACB	1.82e-03	28	32	2	M47647
Pathway	WP_DRAVET_SYNDROME	SCN2A SCN3A	1.82e-03	28	32	2	M45519
Pathway	WP_CANNABINOID_RECEPTOR_SIGNALING	PRKACA PRKACB	1.95e-03	29	32	2	M39676
Pathway	WP_LIPID_METABOLISM_PATHWAY	PRKACA PRKACB	1.95e-03	29	32	2	M39762
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	PRKACA PRKACB	1.95e-03	29	32	2	M47515
Pathway	KEGG_MEDICUS_REFERENCE_TSH_TG_SIGNALING_PATHWAY	PRKACA PRKACB	1.95e-03	29	32	2	M47627
Pathway	WP_GPR143_IN_MELANOCYTES_AND_RETINAL_PIGMENT_EPITHELIUM_CELLS	PRKACA PRKACB	2.09e-03	30	32	2	M42578
Pathway	KEGG_OOCYTE_MEIOSIS	CHP2 PRKACA PRKACB	2.10e-03	113	32	3	M16817
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	NPR2 PRKACA PRKACB	2.21e-03	115	32	3	M9387
Pathway	REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS	PRKACA PRKACB	2.23e-03	31	32	2	MM15094
Pathway	KEGG_MEDICUS_VARIANT_CYP11B1_CYP11B2_FUSION_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	PRKACA PRKACB	2.23e-03	31	32	2	M47507
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN2A SCN3A	2.23e-03	31	32	2	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN2A SCN3A	2.37e-03	32	32	2	M27455
Pathway	KEGG_MEDICUS_REFERENCE_ACTH_CORTISOL_SIGNALING_PATHWAY	PRKACA PRKACB	2.37e-03	32	32	2	M47506
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	PRKACA PRKACB	2.37e-03	32	32	2	MM14983
Pathway	PID_INTEGRIN_A4B1_PATHWAY	PRKACA PRKACB	2.52e-03	33	32	2	M277
Pathway	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION	PRKACA PRKACB	2.52e-03	33	32	2	M11575
Pathway	KEGG_PRION_DISEASES	PRKACA PRKACB	2.83e-03	35	32	2	M13036
Pathway	KEGG_MEDICUS_REFERENCE_ADRB3_UCP1_SIGNALING_PATHWAY	PRKACA PRKACB	2.83e-03	35	32	2	M47969
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	PRKACA PRKACB	2.83e-03	35	32	2	MM15109
Pathway	KEGG_MAPK_SIGNALING_PATHWAY	CACNA1B CHP2 PRKACA PRKACB	2.98e-03	267	32	4	M10792
Pathway	PID_GMCSF_PATHWAY	PRKACA PRKACB	3.00e-03	36	32	2	M22
Pathway	REACTOME_CA_DEPENDENT_EVENTS	PRKACA PRKACB	3.16e-03	37	32	2	M749
Pathway	REACTOME_TRIGLYCERIDE_METABOLISM	PRKACA PRKACB	3.33e-03	38	32	2	M27856
Pathway	REACTOME_RET_SIGNALING	PRKACA PRKACB	3.33e-03	38	32	2	MM15493
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	PRKACA PRKACB	3.51e-03	39	32	2	MM14496
Pathway	REACTOME_RET_SIGNALING	PRKACA PRKACB	3.69e-03	40	32	2	M27746
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	PRKACA PRKACB	3.69e-03	40	32	2	MM15115
Pathway	WP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION	PRKACA PRKACB	3.87e-03	41	32	2	M39655
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	PRKACA PRKACB	3.87e-03	41	32	2	M512
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	PRKACA PRKACB	4.06e-03	42	32	2	M791
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	ADRB1 PRKACA PRKACB	4.09e-03	143	32	3	MM15055
Pathway	REACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION	PRKACA PRKACB	4.25e-03	43	32	2	M29837
Pathway	WP_HEDGEHOG_SIGNALING_WP4249	PRKACA PRKACB	4.25e-03	43	32	2	M39706
Pathway	REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS	PRKACA PRKACB	4.25e-03	43	32	2	M933
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1B ADRB1 PRKACB	4.42e-03	147	32	3	MM15854
Pathway	KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION	PRKACA PRKACB	4.45e-03	44	32	2	M9011
Pathway	WP_VASOPRESSINREGULATED_WATER_REABSORPTION	PRKACA PRKACB	4.45e-03	44	32	2	M42554
Pathway	REACTOME_SIGNALING_BY_GPCR	ARHGEF40 ADRB1 PRKACA PRKACB OBSCN WNT10A	4.46e-03	702	32	6	M746
Pathway	REACTOME_GPER1_SIGNALING	PRKACA PRKACB	4.65e-03	45	32	2	M45008
Pathway	REACTOME_SENSORY_PERCEPTION_OF_TASTE	SCN2A SCN3A	5.06e-03	47	32	2	M42524
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	ADRB1 PRKACA PRKACB	5.30e-03	157	32	3	M4904
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	PRKACA PRKACB	6.17e-03	52	32	2	M920
Pathway	BIOCARTA_PPARA_PATHWAY	PRKACB ME1	6.17e-03	52	32	2	M2404
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	POM121 LEMD3	6.40e-03	53	32	2	M27212
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	PRKACA PRKACB	6.64e-03	54	32	2	M26911
Pathway	KEGG_VIBRIO_CHOLERAE_INFECTION	PRKACA PRKACB	6.64e-03	54	32	2	M17906
Pathway	REACTOME_NEURONAL_SYSTEM	CACNA1B LRFN1 PRKACA PRKACB	6.66e-03	335	32	4	MM14503
Pubmed	Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.	SCN2A SCN3A	2.03e-06	2	50	2	20346423
Pubmed	Systems-level identification of PKA-dependent signaling in epithelial cells.	PRKACA PRKACB	2.03e-06	2	50	2	28973931
Pubmed	Polymorphisms of beta-adrenoceptor and natriuretic peptide receptor genes influence the susceptibility to and the severity of idiopathic dilated cardiomyopathy in a Chinese cohort.	NPR2 ADRB1	2.03e-06	2	50	2	20123316
Pubmed	Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.	PRKACA PRKACB	2.03e-06	2	50	2	36152045
Pubmed	PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.	PRKACA PRKACB	2.03e-06	2	50	2	38841868
Pubmed	Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase.	PRKACA PRKACB	2.03e-06	2	50	2	3023318
Pubmed	Global consequences of activation loop phosphorylation on protein kinase A.	PRKACA PRKACB	2.03e-06	2	50	2	19965870
Pubmed	Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.	SCN2A SCN3A	2.03e-06	2	50	2	11245985
Pubmed	Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.	PRKACA PRKACB	2.03e-06	2	50	2	37871652
Pubmed	Molecular and behavioral effects of a null mutation in all PKA C beta isoforms.	PRKACA PRKACB	2.03e-06	2	50	2	12139926
Pubmed	A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes.	ADRB1 PRKACA	2.03e-06	2	50	2	24713698
Pubmed	Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis.	PRKACA PRKACB	2.03e-06	2	50	2	12180908
Pubmed	Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.	SCN2A SCN3A	2.03e-06	2	50	2	23016767
Pubmed	Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.	SCN2A SCN3A	2.03e-06	2	50	2	27153334
Pubmed	Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase.	PRKACA PRKACB	2.03e-06	2	50	2	2833513
Pubmed	Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct.	PRKACA PRKACB	2.03e-06	2	50	2	31678302
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	CRTC3 POM121 PNPLA6 RBM12B LEMD3 PRKACA PRKACB	3.96e-06	457	50	7	32344865
Pubmed	β1-Adrenergic receptor signaling activates the epithelial calcium channel, transient receptor potential vanilloid type 5 (TRPV5), via the protein kinase A pathway.	ADRB1 PRKACA	6.07e-06	3	50	2	24828496
Pubmed	Voltage-gated sodium channels in taste bud cells.	SCN2A SCN3A	6.07e-06	3	50	2	19284629
Pubmed	A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning.	PRKACA PRKACB	6.07e-06	3	50	2	8548807
Pubmed	Epidermal growth factor receptor levels are reduced in mice with targeted disruption of the protein kinase A catalytic subunit.	PRKACA PRKACB	6.07e-06	3	50	2	18380891
Pubmed	Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.	SCN2A SCN3A	6.07e-06	3	50	2	16052353
Pubmed	Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.	PRKACA PRKACB	6.07e-06	3	50	2	2342480
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN2A SCN3A	6.07e-06	3	50	2	12610651
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN2A SCN3A	6.07e-06	3	50	2	23859570
Pubmed	Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein.	PRKACA PRKACB	6.07e-06	3	50	2	12842892
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN2A SCN3A	6.07e-06	3	50	2	14973256
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN2A SCN3A	6.07e-06	3	50	2	18784617
Pubmed	The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits.	PRKACA PRKACB	6.07e-06	3	50	2	19383776
Pubmed	Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing.	PRKACA PRKACB	6.07e-06	3	50	2	17594903
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN2A SCN3A	6.07e-06	3	50	2	17544618
Pubmed	Cross-talk from β-adrenergic receptors modulates α2A-adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin.	ADRB1 PRKACA	1.21e-05	4	50	2	23965992
Pubmed	Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway.	PRKACA PRKACB	1.21e-05	4	50	2	23116618
Pubmed	Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation.	PRKACA PRKACB	1.21e-05	4	50	2	15111495
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN2A SCN3A	1.21e-05	4	50	2	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN2A SCN3A	1.21e-05	4	50	2	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN2A SCN3A	1.21e-05	4	50	2	29578003
Pubmed	GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.	PRKACA PRKACB	1.21e-05	4	50	2	31112131
Pubmed	Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C.	PRKACA PRKACB	1.21e-05	4	50	2	23709216
Pubmed	Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype.	PRKACA PRKACB	1.21e-05	4	50	2	18385332
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN2A SCN3A	1.21e-05	4	50	2	35801810
Pubmed	Cloning of a mouse protein kinase A catalytic subunit pseudogene and chromosomal mapping of C subunit isoforms.	PRKACA PRKACB	1.21e-05	4	50	2	7873880
Pubmed	Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.	PRKACA PRKACB	1.21e-05	4	50	2	33058759
Pubmed	Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.	PRKACA PRKACB	1.21e-05	4	50	2	21852354
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN2A SCN3A	1.21e-05	4	50	2	8974318
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN2A SCN3A	2.02e-05	5	50	2	1679748
Pubmed	PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation.	PRKACA PRKACB	2.02e-05	5	50	2	28934360
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN2A SCN3A	2.02e-05	5	50	2	8812438
Pubmed	Developmentally acquired PKA localisation in mouse oocytes and embryos.	PRKACA PRKACB	2.02e-05	5	50	2	18367160
Pubmed	HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction.	PRKACA PRKACB	2.02e-05	5	50	2	21745501
Pubmed	HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling.	PRKACA PRKACB	2.02e-05	5	50	2	12972513
Pubmed	Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts.	PRKACA PRKACB	2.02e-05	5	50	2	9540970
Pubmed	PKA-mediated stabilization of FoxH1 negatively regulates ERalpha activity.	PRKACA PRKACB	2.02e-05	5	50	2	19711044
Pubmed	Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls.	PRKACA PRKACB	2.02e-05	5	50	2	19573263
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN2A SCN3A	2.02e-05	5	50	2	24337656
Pubmed	Involvement of protein kinase A in patterning of the mouse somatosensory cortex.	PRKACA PRKACB	2.02e-05	5	50	2	16707791
Pubmed	Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways.	PRKACA PRKACB	2.02e-05	5	50	2	19483721
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN2A SCN3A	2.02e-05	5	50	2	17724025
Pubmed	Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation.	PRKACA PRKACB	3.03e-05	6	50	2	19197368
Pubmed	Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis.	PRKACA PRKACB	3.03e-05	6	50	2	30385877
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN2A SCN3A	3.03e-05	6	50	2	23652591
Pubmed	Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy.	PRKACA PRKACB	3.03e-05	6	50	2	17557924
Pubmed	Architectural DNA-binding properties of the spermatidal transition proteins 1 and 2.	PRKACA PRKACB	3.03e-05	6	50	2	9837753
Pubmed	Dynamic binding of PKA regulatory subunit RI alpha.	PRKACA PRKACB	4.23e-05	7	50	2	16407073
Pubmed	Distinct patterns of cAMP-dependent protein kinase gene expression in mouse brain.	PRKACA PRKACB	4.23e-05	7	50	2	2619996
Pubmed	Phosphorylation of HIV Nef by cAMP-dependent protein kinase.	PRKACA PRKACB	4.23e-05	7	50	2	15629779
Pubmed	Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha.	PRKACA PRKACB	5.64e-05	8	50	2	8794865
Pubmed	Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes.	SYNPO2 PRKACA	5.64e-05	8	50	2	17923693
Pubmed	Control of PKA stability and signalling by the RING ligase praja2.	PRKACA PRKACB	5.64e-05	8	50	2	21423175
Pubmed	Probing cellular protein complexes using single-molecule pull-down.	ADRB1 PRKACA	5.64e-05	8	50	2	21614075
Pubmed	Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).	PRKACA PRKACB	5.64e-05	8	50	2	12628924
Pubmed	CCL3L1 prevents gp120-induced neuron death via the CREB cell signaling pathway.	PRKACA PRKACB	5.64e-05	8	50	2	19100722
Pubmed	Ellis-van Creveld Syndrome	PRKACA PRKACB	7.25e-05	9	50	2	37903214
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN2A SCN3A	7.25e-05	9	50	2	15746173
Pubmed	Protein kinase A deficiency causes axially localized neural tube defects in mice.	PRKACA PRKACB	7.25e-05	9	50	2	11886853
Pubmed	Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.	PRKACA PRKACB	7.25e-05	9	50	2	7688126
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN2A SCN3A	7.25e-05	9	50	2	16382098
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	CRTC3 PIMREG LONRF2 DHX34 ARHGAP33	7.94e-05	307	50	5	37499664
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	IGSF10 LRFN1 OBSCN ILDR1	8.84e-05	162	50	4	25826454
Pubmed	HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition.	PRKACA PRKACB	9.05e-05	10	50	2	20433920
Pubmed	Neural crest-specific loss of Prkar1a causes perinatal lethality resulting from defects in intramembranous ossification.	PRKACA PRKACB	1.10e-04	11	50	2	20534695
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	SCN2A SCN3A	1.32e-04	12	50	2	8169823
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN2A SCN3A	1.32e-04	12	50	2	30175250
Pubmed	PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.	PRKACA PRKACB	1.32e-04	12	50	2	10830164
Pubmed	Viral genetic determinants of nonprogressive HIV type 1 subtype C infection in antiretroviral drug-naive children.	PRKACA PRKACB	1.56e-04	13	50	2	19895210
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN2A SCN3A	1.56e-04	13	50	2	15123669
Pubmed	Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif.	PRKACA PRKACB	1.56e-04	13	50	2	18836454
Pubmed	The HIV-1 matrix protein p17 activates the transcription factors c-Myc and CREB in human B cells.	PRKACA PRKACB	1.56e-04	13	50	2	20402410
Pubmed	Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection.	PRKACA PRKACB	1.56e-04	13	50	2	20392842
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TYK2 ARHGEF40 LRFN1 PNPLA6 OBSCN ZNF398 DHX34 ARHGAP33	1.66e-04	1105	50	8	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TYK2 ZNF526 ARHGEF40 PNPLA6 DROSHA RERE DHX34 ARHGAP33	1.78e-04	1116	50	8	31753913
Pubmed	Genetic mapping of the mouse genes encoding the voltage-sensitive calcium channel subunits.	CACNA1B SCN3A	1.82e-04	14	50	2	7490102
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	SCN2A SCN3A	2.10e-04	15	50	2	9726281
Pubmed	cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.	PRKACA PRKACB	2.10e-04	15	50	2	2165385
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	ZNF526 SYNPO2 ZNF275 DHX34	2.71e-04	217	50	4	34048709
Pubmed	Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner.	LEFTY1 LEMD3	2.72e-04	17	50	2	18697220
Pubmed	Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all.	PRKACA PRKACB	2.72e-04	17	50	2	24189052
Pubmed	Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.	PRKACA PRKACB	4.18e-04	21	50	2	22007132
Pubmed	The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.	PRKACA PRKACB	4.18e-04	21	50	2	22114277
Pubmed	Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.	PRKACA PRKACB	4.18e-04	21	50	2	9671211
Cytoband	19q13.2	ZNF526 LRFN1 CCNP	7.75e-04	164	50	3	19q13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	TYK2 ZNF878 PNPLA6 PRKACA FBN3	1.73e-03	797	50	5	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF526 LRFN1 ZNF837 CCNP DHX34 ARHGAP33	1.81e-03	1192	50	6	chr19q13
Cytoband	19p13.2	TYK2 ZNF878 PNPLA6	2.02e-03	229	50	3	19p13.2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF526 ZNF878 ZSCAN10 ZSCAN30 ZNF837 ZNF398 KLF15 ZNF275	5.40e-05	718	35	8	28
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN2A SCN3A	1.30e-04	9	35	2	1203
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	IGSF10 LRFN1 OBSCN	3.68e-03	161	35	3	593
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF40 OBSCN	7.23e-03	66	35	2	722
Coexpression	ZHONG_PFC_C3_ASTROCYTE	CACNA1B PNPLA6 SCN3A OBSCN RERE CBFA2T3 FBN3	7.55e-06	389	49	7	M39102
Coexpression	GSE45365_WT_VS_IFNAR_KO_CD8A_DC_MCMV_INFECTION_UP	TYK2 CRTC3 PNPLA6 PRKACA RERE	3.49e-05	199	49	5	M9964
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CACNA1B SCN2A PRKACB CAMTA1 LONRF2	2.08e-06	186	50	5	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	Control-Endothelial-Endothelial-Activated_Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ENTPD7 ARHGEF40 ADRB1 BTBD19	1.04e-05	121	50	4	a5962d1c476e6966870832b72d511607e047248b
ToppCell	BAL-Mild-cDC_5\|Mild / Compartment, Disease Groups and Clusters	NPR2 PRKACA DHX34 ARHGAP33	3.20e-05	161	50	4	7a6e8ed0b5d999efce8945d8083ab01d71be9a92
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SCN2A SCN3A LONRF2 FBN3	3.61e-05	166	50	4	6fe8db8d45177a78605681f22e04fa8d0594f2df
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_memory-B_memory-0\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SCN2A BRWD1-AS2 ILDR1 CBFA2T3	4.84e-05	179	50	4	fce1ba53815145f6248d4e90aedca3dad84e33e4
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CACNA1B SCN2A SCN3A PRKACB	5.85e-05	188	50	4	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNNM2 ADRB1 ILDR1 CAMTA1	5.85e-05	188	50	4	d2d2b6c49448da24f457cedcd213f68841834a99
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNNM2 ADRB1 ILDR1 CAMTA1	5.85e-05	188	50	4	ab6fa1beff91584d9303c2a33735de89aae8d5cd
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	IGSF10 ADRB1 SCN2A SCN3A	6.10e-05	190	50	4	6e92c78799f34b31d098854503c796edb0dc7f80
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-ELP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SCN3A PRKACB RERE CBFA2T3	6.35e-05	192	50	4	38ec82aa2ec4f2c0a843e83f7fe54f6b2483ca3d
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IGSF10 NPR2 SCN3A KLF15	6.35e-05	192	50	4	ff4b728a55c2550c806c47e9ae3d057c35df8464
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-alveolar_fibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IGSF10 NPR2 SCN3A KLF15	6.35e-05	192	50	4	2d3790bd80a7f214b37094121a2a86ff16362569
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGSF10 CACNA1B SCN3A LONRF2	6.48e-05	193	50	4	a189d46c39067b717509cd144e0225cc93d7731d
ToppCell	severe-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LEFTY1 SCN2A SCN3A ILDR1	6.61e-05	194	50	4	2fee6083fb56b16d1f04fd0b92ec622fd26ba3fa
ToppCell	severe-B_cell\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LEFTY1 SCN2A SCN3A ILDR1	6.74e-05	195	50	4	0fc3c605609c9e6bdea15d73c45def2188ae5fb1
ToppCell	Frontal_cortex-Neuronal\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SCN2A PRKACA CAMTA1 LONRF2	7.29e-05	199	50	4	f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCell	Striatum-Neuronal\|Striatum / BrainAtlas - Mouse McCarroll V32	SCN2A PRKACB CAMTA1 LONRF2	7.44e-05	200	50	4	c888fd487990cad482a4ca47601cdebc0ca3f3ce
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SYNPO2 CNNM2 LEMD3 KLF15	7.44e-05	200	50	4	a372ef3f9e6ff6e3c3376d6e10182977c5067788
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN2A SCN3A	1.06e-04	10	46	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN2A SCN3A	1.06e-04	10	46	2	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN2A SCN3A	1.55e-04	12	46	2	DOID:0060170 (implicated_via_orthology)
Disease	anxiety disorder (implicated_via_orthology)	SCN2A SCN3A	5.38e-04	22	46	2	DOID:2030 (implicated_via_orthology)
Disease	Intrahepatic Cholangiocarcinoma	PRKACA PRKACB	6.42e-04	24	46	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	PRKACA PRKACB	6.42e-04	24	46	2	C3805278
Disease	macular telangiectasia type 2	KLF15 FBN3	7.55e-04	26	46	2	EFO_1002009
Disease	Cholangiocarcinoma	PRKACA PRKACB	7.55e-04	26	46	2	C0206698
Disease	congestive heart failure (is_implicated_in)	ADRB1 PRKACA	8.14e-04	27	46	2	DOID:6000 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
AHEHPSSPRRRSYRR	BEST3	401	Q8N1M1
PSERRRHSPLERSRH	C2orf16	1801	Q68DN1
RHSPLERSRHSLLER	C2orf16	1806	Q68DN1
ERSRHSLLERSHRSP	C2orf16	1811	Q68DN1
RAARRRHATHGDRPR	ADRB1	396	P08588
RRSPLREARRANPHF	BRWD1-AS2	71	P59051
FLRRCRHSPLVDHRL	CAMTA1	1646	Q9Y6Y1
ERLRSFHRTHFLREL	ARHGEF40	1131	Q8TER5
VSSFRIRHRPHDQLR	NPR2	941	P20594
AERRILSRLDFRLHH	CCNP	191	Q9H8S5
LSPRDRPRRSAHRDH	FBN3	2681	Q75N90
RRHHRRGSPEEAAER	CACNA1B	916	Q00975
HFRRPPQEHFRRSRE	RBM12B	786	Q8IXT5
LKDDSLSRHRPRRTH	LEMD3	276	Q9Y2U8
HLHLRCPRRLFSRRS	PNPLA6	931	Q8IY17
SHLRRIGRFSEPHAR	PRKACA	131	P17612
HRHGRLSPRSARARV	LEFTY1	131	O75610
PRRRHTHQRGYLLTR	ME1	6	P48163
RLRRIHHRQTRASAP	ENTPD7	571	Q9NQZ7
SHSYPRRARRTKRHR	LRFN1	716	Q9P244
RRARRTKRHRSTPHL	LRFN1	721	Q9P244
TQRHGRRRRHRSYSP	ILDR1	456	Q86SU0
AIGISRFRVLSHRHR	LONRF2	611	Q1L5Z9
AHPLRRSRREAAFRS	PIMREG	171	Q9BSJ6
AYRHPDPRELRERHR	CBFA2T3	356	O75081
ALAPGSRRHPARRRH	OBSCN	6886	Q5VST9
THHARRRRRARLPAP	PANO1	196	I0J062
SRPLSSFVRKARHRR	POM121	76	Q96HA1
ARHRRPLSSFVRKAR	POM121	86	Q96HA1
RLHRLRRPHSSSDAF	ARHGAP33	651	O14559
CRRRRGTLPREHHRF	BTBD19	271	C9JJ37
DSTHRRFRENRRHFP	IGSF10	731	Q6WRI0
SHLRRIGRFSEPHAR	PRKACB	131	P22694
ERPSRNRFHPLHRRS	CRTC3	96	Q6UUV7
RFSRSDELSRHRRSH	KLF15	361	Q9UIH9
CSLSHHRPRLFHRRR	LCE2C	71	Q5TA81
RTRHLRSRDFLAPHR	DALRD3	31	Q5D0E6
TREGRDRRDHHRAPS	DHX34	6	Q14147
RHRHRDNRRSPSLER	DROSHA	291	Q9NRR4
SRRDSLFVPHRHGER	SCN3A	606	Q9NY46
TPEAASSRAHRRHRR	RERE	441	Q9P2R6
RCLEHALTARHPRTR	RDH5	266	Q92781
ASLLRLHHRFRALDR	CHP2	26	O43745
SRIAFTEHERRRHSP	CNNM2	116	Q9H8M5
HSAERHRRGPVLARR	ZNF837	321	Q96EG3
RFVRRASLARHLLTH	ZSCAN10	531	Q96SZ4
FRGSSELIRHRRIHT	ZSCAN30	366	Q86W11
HRARHARLRRSESLS	SYNPO2	351	Q9UMS6
RLTSHRRAHASERPF	ZNF398	441	Q8TD17
SRRDSLFVPHRHGER	SCN2A	606	Q99250
HRRLHLRPVAFARAP	ZNF526	546	Q8TF50
RSRFHRATLIRPHNR	WNT10A	291	Q9GZT5
FRRSSGLSRHRRIHS	ZNF275	386	Q9NSD4
AFRFPSSVRRHERIH	ZNF878	151	C9JN71
PRSFRRHIRQHSALT	TYK2	216	P29597