Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	FAM47	FAM47A FAM47C FAM47B	3.25e-07	4	82	3	PF14642
Domain	FAM47	FAM47A FAM47C FAM47B	3.25e-07	4	82	3	IPR032743
Domain	DUF3504	ZMYM2 KIAA1958	1.89e-04	5	82	2	IPR021893
Domain	DUF3504	ZMYM2 KIAA1958	1.89e-04	5	82	2	PF12012
Domain	Olfact_rcpt	OR1N1 OR2M4 OR1S1 OR2G2 OR1D5 OR2A5 OR1D4 OR1D2	3.28e-04	393	82	8	IPR000725
Pubmed	Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis.	STK4 TJP1 PARD3	4.40e-06	13	88	3	29712669
Pubmed	ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.	ZDHHC11B ZDHHC11	6.33e-06	2	88	2	28331227
Pubmed	The mouse ZFH-4 protein contains four homeodomains and twenty-two zinc fingers.	ZFHX4 ZFHX3	6.33e-06	2	88	2	10873665
Pubmed	Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences.	OR1D5 OR1D2	6.33e-06	2	88	2	1315913
Pubmed	Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.	TAOK2 TAOK1	6.33e-06	2	88	2	28830982
Pubmed	Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA.	TJP1 CCNB1	6.33e-06	2	88	2	35471687
Pubmed	Par3 and ZO-1 Membrane Clustering is an Indicator of Poor Prognosis in Lung Squamous Cell Carcinoma.	TJP1 PARD3	6.33e-06	2	88	2	34216486
Pubmed	Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization.	ZDHHC11B ZDHHC11	6.33e-06	2	88	2	35384384
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	ZNF462 ZFHX4 CDK2AP1 ZMYM2 ZFHX3	6.66e-06	103	88	5	32744500
Pubmed	Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.	OR1D5 OR1D4 OR1D2	8.56e-06	16	88	3	10673334
Pubmed	Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades.	TAOK2 TAOK1	1.90e-05	3	88	2	9786855
Pubmed	TAO kinases mediate activation of p38 in response to DNA damage.	TAOK2 TAOK1	1.90e-05	3	88	2	17396146
Pubmed	ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†.	ZDHHC11B ZDHHC11	1.90e-05	3	88	2	34897408
Pubmed	Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.	TAOK2 TAOK1	1.90e-05	3	88	2	23585562
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR1N1 OR2M4 OR1D5 OR2A5 OR1D4 OR1D2	2.05e-05	219	88	6	12213199
Pubmed	Interaction network of human early embryonic transcription factors.	ZNF462 SOX5 ALMS1 ZFHX4 TNPO2 ZMYM2 ZFHX3	3.16e-05	351	88	7	38297188
Pubmed	ADAMTS18 regulates early branching morphogenesis of lacrimal gland and has a significant association with the risk of dry eye in mice.	TJP1 PARD3	3.79e-05	4	88	2	35240198
Pubmed	Behavioral abnormalities observed in Zfhx2-deficient mice.	ZFHX4 ZFHX3	3.79e-05	4	88	2	23300874
Pubmed	ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association.	ZDHHC11B ZDHHC11	3.79e-05	4	88	2	29429998
Pubmed	Formin homology 2 domain-containing 3 (Fhod3) controls neural plate morphogenesis in mouse cranial neurulation by regulating multidirectional apical constriction.	TJP1 FHOD3	3.79e-05	4	88	2	30573686
Pubmed	Formation and contraction of multicellular actomyosin cables facilitate lens placode invagination.	TJP1 PARD3	3.79e-05	4	88	2	32113830
Pubmed	Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain.	TAOK2 TAOK1	3.79e-05	4	88	2	10497253
Pubmed	Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex.	TJP1 PARD3	3.79e-05	4	88	2	19640478
Pubmed	Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders.	SOX5 ZFHX4 ZMYM2	4.90e-05	28	88	3	29365100
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	TAOK2 ZNF384 TJP1 TAOK1 PARD3	5.41e-05	159	88	5	30581152
Pubmed	Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.	TAOK2 TAOK1	6.30e-05	5	88	2	13679851
Pubmed	Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.	TAOK2 TAOK1	6.30e-05	5	88	2	22683681
Pubmed	Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.	TJP1 PARD3	6.30e-05	5	88	2	35283834
Pubmed	Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.	CGB1 SCG2	9.43e-05	6	88	2	21521715
Pubmed	The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity.	TJP1 PARD3	9.43e-05	6	88	2	12953056
Pubmed	ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization.	ZDHHC11B ZDHHC11	9.43e-05	6	88	2	34490261
Pubmed	Non-cell autonomous and non-catalytic activities of ATX in the developing brain.	TJP1 PARD3	9.43e-05	6	88	2	25788872
Pubmed	The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability.	TAOK2 TAOK1	9.43e-05	6	88	2	12639963
Pubmed	Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.	TAOK2 TAOK1	9.43e-05	6	88	2	16893890
Pubmed	FGF signaling gradient maintains symmetrical proliferative divisions of midbrain neuronal progenitors.	TJP1 PARD3 CCNB1	9.66e-05	35	88	3	21074523
Pubmed	Sporadic Hirschsprung Disease: Mutational Spectrum and Novel Candidate Genes Revealed by Next-generation Sequencing.	PHKB ZFHX3	1.32e-04	7	88	2	29093530
Pubmed	Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization.	TJP1 PARD3	1.32e-04	7	88	2	28369449
Pubmed	In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.	ZDHHC11B ZDHHC11	1.32e-04	7	88	2	23687301
Pubmed	Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells.	TJP1 PARD3	1.75e-04	8	88	2	12203721
Pubmed	Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF.	TJP1 PARD3	1.75e-04	8	88	2	22006950
Pubmed	FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.	TJP1 PARD3	1.75e-04	8	88	2	20080746
Pubmed	Mouse-human orthology relationships in an olfactory receptor gene cluster.	OR1D5 OR1D2	1.75e-04	8	88	2	11170746
Pubmed	Nectins localize Willin to cell-cell junctions.	TJP1 PARD3	1.75e-04	8	88	2	22512338
Pubmed	Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.	ZNF462 ZNF384 CDK2AP1 DDX18 ZFHX3 TDP1	2.03e-04	332	88	6	30595499
Pubmed	Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.	STK4 TJP1	2.25e-04	9	88	2	28169360
Pubmed	Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse.	TJP1 PARD3	2.25e-04	9	88	2	12515806
Pubmed	Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation.	GTF2H1 CCNB1	2.25e-04	9	88	2	20974803
Pubmed	The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.	TJP1 PARD3	2.25e-04	9	88	2	21074722
Pubmed	Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.	TJP1 PARD3	2.25e-04	9	88	2	11257119
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF462 PARP4 ALMS1 DYNC2H1 TOGARAM1 TAOK1 MAST3	2.60e-04	493	88	7	15368895
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ZNF462 AMPD1 PARP4 ALMS1 NEB PARD3 CCNB1	2.73e-04	497	88	7	23414517
Pubmed	Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal.	TJP1 PARD3	2.81e-04	10	88	2	32150534
Pubmed	CD44 regulates tight-junction assembly and barrier function.	TJP1 PARD3	2.81e-04	10	88	2	21191420
Pubmed	Multicellular rosettes link mesenchymal-epithelial transition to radial intercalation in the mouse axial mesoderm.	TJP1 PARD3	3.43e-04	11	88	2	37080203
Pubmed	HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.	TJP1 PARD3	3.43e-04	11	88	2	28994651
Pubmed	Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.	OR1D4 OR1D2	3.43e-04	11	88	2	8004088
Pubmed	The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1.	STK4 TAOK1	4.11e-04	12	88	2	35027733
Pubmed	A cell polarity protein aPKClambda is required for eye lens formation and growth.	TJP1 PARD3	4.11e-04	12	88	2	19835853
Pubmed	Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.	USP10 STPG2	4.11e-04	12	88	2	24009623
Pubmed	The human olfactory receptor gene family.	OR1N1 OR2M4 OR1S1 OR2G2 OR1D5 OR1D4 OR1D2	4.54e-04	541	88	7	14983052
Pubmed	PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains.	TJP1 PARD3	4.85e-04	13	88	2	16510507
Pubmed	Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development.	TJP1 PARD3	4.85e-04	13	88	2	26490995
Pubmed	Endfoot regeneration restricts radial glial state and prevents translocation into the outer subventricular zone in early mammalian brain development.	TJP1 PARD3	4.85e-04	13	88	2	31871317
Pubmed	Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia.	TJP1 PARD3	4.85e-04	13	88	2	28482867
Pubmed	A molecular blueprint at the apical surface establishes planar asymmetry in cochlear hair cells.	TJP1 PARD3	4.85e-04	13	88	2	24135232
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	HSPA4L TJP1 TNPO2 DDX18 ZMYM2 SNRPA	5.05e-04	394	88	6	27248496
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	SOX5 ZFHX4 HSPA4L DYNC2H1 TNPO2 CCNB1	5.32e-04	398	88	6	35016035
Pubmed	Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling.	TJP1 PARD3	5.65e-04	14	88	2	21396893
Pubmed	Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo.	TJP1 PARD3	5.65e-04	14	88	2	26631503
Pubmed	Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities.	TJP1 PARD3	5.65e-04	14	88	2	24381198
Pubmed	Epicardial spindle orientation controls cell entry into the myocardium.	TJP1 PARD3	5.65e-04	14	88	2	20643355
Pubmed	Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure.	TJP1 PARD3	6.51e-04	15	88	2	34029538
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZNF462 ALMS1 ZFHX4 ZMYM2 KIAA1958 ZFHX3	6.87e-04	418	88	6	34709266
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	TAOK2 ZNF384 ZFHX4 HSPA4L ZMYM2 ZFHX3 CCNB1	7.06e-04	583	88	7	29844126
Pubmed	Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.	ZNF462 ZFHX4	7.42e-04	16	88	2	16096065
Pubmed	Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity.	TJP1 PARD3	7.42e-04	16	88	2	32460029
Pubmed	Pdx1 regulates pancreas tubulogenesis and E-cadherin expression.	TJP1 PARD3	7.42e-04	16	88	2	26657766
Pubmed	Phosphorylated β-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain.	TJP1 PARD3	7.42e-04	16	88	2	21736876
Pubmed	Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling.	CACNA1B ZFHX3	7.42e-04	16	88	2	17444492
Pubmed	TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field.	TJP1 PARD3	7.42e-04	16	88	2	25371366
Pubmed	EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development.	TJP1 PARD3	7.42e-04	16	88	2	33605987
Pubmed	Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.	TJP1 PARD3	7.42e-04	16	88	2	20823064
Pubmed	A large family of endosome-localized proteins related to sorting nexin 1.	SNX8 SNX13	8.40e-04	17	88	2	11485546
Pubmed	Sorting out the cellular functions of sorting nexins.	SNX8 SNX13	8.40e-04	17	88	2	12461558
Pubmed	Numb is required for the production of terminal asymmetric cell divisions in the developing mouse retina.	TJP1 PARD3	8.40e-04	17	88	2	23197712
Pubmed	Wnts regulate planar cell polarity via heterotrimeric G protein and PI3K signaling.	TJP1 PARD3	8.40e-04	17	88	2	32805026
Pubmed	Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.	TJP1 DYNC2H1	8.40e-04	17	88	2	22357932
Pubmed	Network organization of the human autophagy system.	ATG101 STK4 USP10 TJP1 TAOK1 MAST3	8.65e-04	437	88	6	20562859
Pubmed	A neurogenomics approach to gene expression analysis in the developing brain.	CALU SCG2 ZFHX3 RUFY3	9.33e-04	170	88	4	15582152
Pubmed	Huntingtin regulates mammary stem cell division and differentiation.	TJP1 PARD3	9.43e-04	18	88	2	24749073
Pubmed	Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development.	TJP1 PARD3	9.43e-04	18	88	2	26209645
Pubmed	Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles.	TJP1 PARD3	9.43e-04	18	88	2	29229865
Pubmed	RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.	USP10 TJP1	9.43e-04	18	88	2	27558965
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	STK4 USP10 ALMS1 TJP1 PARD3 RUFY3	9.61e-04	446	88	6	24255178
Pubmed	HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention.	GTF2H1 CCNB1	1.05e-03	19	88	2	21489275
Pubmed	Gli3 is required for the specification and differentiation of preplate neurons.	TJP1 PARD3	1.05e-03	19	88	2	16168404
Pubmed	ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development.	TJP1 PARD3	1.05e-03	19	88	2	20619750
Pubmed	The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.	ZFHX4 ZFHX3	1.17e-03	20	88	2	35177643
Pubmed	Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon.	TJP1 PARD3	1.17e-03	20	88	2	26802325
Pubmed	Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.	SOX5 FHOD3	1.29e-03	21	88	2	20195266
Cytoband	Xp21.1	FAM47A FAM47C FAM47B	3.90e-05	34	88	3	Xp21.1
Cytoband	Ensembl 112 genes in cytogenetic band chrXp21	FAM47A FAM47C FAM47B	5.80e-04	84	88	3	chrXp21
Cytoband	17p13.3	OR1D5 OR1D4 OR1D2	6.64e-04	88	88	3	17p13.3
Cytoband	5p15.33	ZDHHC11B ZDHHC11	1.74e-03	32	88	2	5p15.33
GeneFamily	Olfactory receptors, family 1	OR1N1 OR1S1 OR1D5 OR1D4 OR1D2	2.22e-07	40	61	5	147
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZFHX4 ZFHX3	1.14e-03	15	61	2	529
GeneFamily	Armadillo repeat containing\|Importins	IPO8 TNPO2	1.65e-03	18	61	2	596
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC11B ZDHHC11	2.95e-03	24	61	2	76
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	TAOK2 TAOK1	2.95e-03	24	61	2	654
GeneFamily	Sorting nexins\|PX-BAR domain containing	SNX8 SNX13	4.29e-03	29	61	2	754
CoexpressionAtlas	DevelopingGonad_e11.5_testes_emap-3226_k-means-cluster#1_top-relative-expression-ranked_1000	ZNF462 SOX5 ZFHX4 KIAA1958 RUFY3	1.92e-05	89	78	5	gudmap_developingGonad_e11.5_testes_k1_1000
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EECs\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SOX5 SCG2 ZDHHC11 RNF24 STPG2 AMIGO2	1.16e-06	171	88	6	dd37e1693a5cfc42e40992d504f92048a8038b52
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCG2 HCN1 BEX4 ST8SIA5 PLEKHD1 UNC5D	1.56e-06	180	88	6	3d54cc767e25d91ed2203d8a03e5bf5e15f21699
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-intermediate_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CACNA1B SCG2 OGDHL ST8SIA5 HEPACAM2 UNC5D	1.77e-06	184	88	6	9e5f98f9113e5e38bdadba6d9d2c346177fb35fe
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1B SCG2 HCN1 HEPACAM2 UNC5D AMIGO2	2.00e-06	188	88	6	c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B OGDHL ZFHX3 HEPACAM2 RNF24	2.09e-05	168	88	5	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Pulmonary_NE_precursor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SCG2 ST8SIA5 HEPACAM2 PRRT1B AMIGO2	2.21e-05	170	88	5	98d13dbd76a826e47d55553f9d11f71c043b573e
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCG2 SRGAP1 CHST11 PARD3 MN1	2.40e-05	173	88	5	af85fb9f6e26a044ca4d23e5872039b1a7b73b1b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP1 FHOD3 CHST11 PARD3 UNC5D	2.75e-05	178	88	5	a0ab20c588e7d43d0320d4779d9ab95c1c86e297
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	CACNA1B SCG2 HCN1 HEPACAM2 UNC5D	3.06e-05	182	88	5	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF462 ZFHX4 CHST11 PARD3 TNR	3.06e-05	182	88	5	8a8b08ac4bb3cba3541dbe234e088703842285b9
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF462 ZFHX4 CHST11 PARD3 TNR	3.06e-05	182	88	5	e36766309c4d96a90d213ce37d3acef1029a3fdc
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF462 ZFHX4 CHST11 PARD3 TNR	3.31e-05	185	88	5	2e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF462 ZFHX4 CHST11 PARD3 TNR	3.31e-05	185	88	5	7aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TLR10 SOX5 RHOBTB2 SNX8 NEB	3.40e-05	186	88	5	d7d884ff4184636081c350d29f797bd923c6a3b4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF462 FHOD3 PARD3 UNC5D NR1H4	3.40e-05	186	88	5	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1B SCG2 HCN1 UNC5D AMIGO2	3.40e-05	186	88	5	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF462 FHOD3 PARD3 UNC5D NR1H4	3.48e-05	187	88	5	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	CTRL-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	TLR10 SOX5 PHKB SNX8 MAST3	3.66e-05	189	88	5	14f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCell	15-Trachea-Epithelial-Neuroendocrine\|Trachea / Age, Tissue, Lineage and Cell class	SCG2 ST8SIA5 HEPACAM2 NEB TNR	3.85e-05	191	88	5	76311fa5f3ae9bb27cf04387a8c92300f2888c28
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_atypical\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TLR10 SOX5 RHOBTB2 SNX8 NEB	3.95e-05	192	88	5	24797e80b1f5b3ea5a0410caaf57ccf2ae9d716e
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_atypical-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TLR10 SOX5 RHOBTB2 SNX8 NEB	4.15e-05	194	88	5	b8f05efb16fbed7317019efc3da7f97f81e90972
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SCG2 HCN1 OGDHL HEPACAM2 TNR	4.57e-05	198	88	5	8f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SCG2 CHST11 PARD3 MN1 AMIGO2	4.79e-05	200	88	5	c74bc12e13d002dedaaf75a2244ec111e47524e1
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-BAGE2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SCG2 SRGAP1 CHST11 PARD3 MN1	4.79e-05	200	88	5	26f07d271e984f375145e4c10528fba44a5811e1
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SCG2 CHST11 PARD3 MN1 AMIGO2	4.79e-05	200	88	5	ead9eb579bb25fde05fc15602e3d05ab6617f7ac
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-BAGE2-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SCG2 SRGAP1 CHST11 PARD3 MN1	4.79e-05	200	88	5	c3637827ceba16b0d7956c280dd2ddbc8b1ba55e
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZFHX4 SCG2 CHST11 PARD3 MN1	4.79e-05	200	88	5	d0167f96314be78b6d867bbcc6e4396071d931b8
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZFHX4 SCG2 CHST11 PARD3 MN1	4.79e-05	200	88	5	862db57d043bdf3cb059fbfc8b29bc1eafdf64ec
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	ZFHX4 TNPO2 ZFHX3 RNF24 MAST3	4.79e-05	200	88	5	c92e4fc0442404481fcac623d691dae6215b852d
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR--L1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZFHX4 SCG2 CHST11 PARD3 MN1	4.79e-05	200	88	5	a91345f268f13170c27309333603eb82400c9947
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZFHX4 SCG2 CHST11 PARD3 MN1	4.79e-05	200	88	5	d416a7be1a4e6232fb58a9687774da24821f1fdd
Disease	Global developmental delay	ZNF462 CACNA1B RHOBTB2 TAOK1 MN1	4.48e-05	133	86	5	C0557874
Disease	low density lipoprotein cholesterol measurement, response to escitalopram, response to citalopram	ZFHX3 CHST11 SNX13	4.63e-05	24	86	3	EFO_0004611, EFO_0006329, EFO_0007871
Disease	response to perphenazine	SOX5 HCN1 FHOD3	5.92e-05	26	86	3	GO_0097334
Disease	response to opioid	USP10 IPO8 TNR	7.61e-04	61	86	3	EFO_0008541
Disease	central nervous system disease (implicated_via_orthology)	TAOK2 TAOK1	9.81e-04	16	86	2	DOID:331 (implicated_via_orthology)
Disease	Paroxysmal atrial fibrillation	ZNF462 SOX5 CALU ZFHX3	1.14e-03	156	86	4	C0235480
Disease	familial atrial fibrillation	ZNF462 SOX5 CALU ZFHX3	1.14e-03	156	86	4	C3468561
Disease	Persistent atrial fibrillation	ZNF462 SOX5 CALU ZFHX3	1.14e-03	156	86	4	C2585653
Disease	Atrial Fibrillation	ZNF462 SOX5 CALU ZFHX3	1.25e-03	160	86	4	C0004238
Disease	Craniosynostosis	ZNF462 MN1	1.54e-03	20	86	2	C0010278
Disease	Intellectual Disability	ZNF462 CACNA1B RHOBTB2 ZMYM2 TAOK1 MN1	1.98e-03	447	86	6	C3714756
Disease	response to mTOR inhibitor	USP10 STPG2	2.41e-03	25	86	2	EFO_0005417
Disease	thyroid stimulating hormone measurement	ZDHHC11B LINC00303 SNX8 HEMGN NEB	2.57e-03	323	86	5	EFO_0004748
Disease	Ischemic stroke	SOX5 CDK2AP1 ZFHX3 TNR STPG2	2.61e-03	324	86	5	HP_0002140

Protein segments in the cluster

Peptide	Gene	Start	Entry
HMNMDGDYINIFPKR	ADGRL4	271	Q9HBW9
NYPMQHERKVMQRHP	LINC00303	111	Q3SY05
MDPQEMVVKNPYAHI	CYSRT1	1	A8MQ03
EQQMRHYMRFQTPEP	BEX4	96	Q9NWD9
LYRDGKDQPFMQMPQ	BTNL8	66	Q6UX41
KHREHMCLPLPYQNM	ALMS1	3521	Q8TCU4
RVDPHFRAPKMEMFQ	CGB1	21	A6NKQ9
PDPDDGFNYKQMMVR	CALU	141	O43852
FLDVSYNRIPSMPMH	AMIGO2	196	Q86SJ2
PMQFHFTKEPLMEEY	AMPD1	651	P23109
YNDMFEMLKHMSPPL	CACNA1B	1746	Q00975
LLHFIMDSYNKQRMP	NR1H4	266	Q96RI1
RMLDKDLMPYFQPSA	OTOA	1041	Q7RTW8
VEAQLMTKHPLAMYP	FAM47C	121	Q5HY64
LPFYPDMVNRDTKMA	NXF3	226	Q9H4D5
RPDVMFMVYPLDQNL	OAZ2	171	O95190
PMINPFIYSLRNKDM	OR1S1	296	Q8NH92
VSRLEPKLHMPMYFF	OR2G2	51	Q8NGZ5
LRHQLMPMYNFDPTE	C3orf18	91	Q9UK00
PMFTQPLMYKQIHRQ	OGDHL	506	Q9ULD0
MFMYMRPASKHTPDQ	OR2M4	256	Q96R27
VEAQLMTKHPLAMYP	FAM47B	121	Q8NA70
VMIPFTNANYDSHPM	DSE	31	Q9UL01
QLQKMMTEFYRLIPH	PARP4	316	Q9UKK3
RLLDHMQNTPGFMYK	DDX18	311	Q9NVP1
IQDHPFKMYQDMAKR	HEMGN	211	Q9BXL5
IVMYMAPKSRHPEEQ	OR2A5	256	Q96R48
KAMPRYQLLGHIDMD	DYNC2H1	2011	Q8NCM8
VEVMNRHEYLPKMPT	ATG101	156	Q9BSB4
MLDYDMVHFPPSQIA	CCNB1	331	P14635
QYMSFHKLPADMRQK	HCN1	416	O60741
RFMLDMLYAHNRKSP	FHOD3	676	Q2V2M9
MSYKPNLAAHMPAAA	CDK2AP1	1	O14519
MMNHVYRERFPKATA	MAST3	171	O60307
VEAQLMAKHPLAMYP	FAM47A	121	Q5JRC9
DLEYQHKFTMMPPNA	HEPACAM2	91	A8MVW5
KHLPQQPTLSDMTMY	PHKB	961	Q93100
IMYMAPKSRHPEEQQ	OR2A1;	256	Q8NGT9
HMMDALYAQVKKPRN	PARD3	1121	Q8TEW0
QAKEYMKPHVRPIMQ	IPO8	531	O15397
TPMMNPFIYSLRNKD	OR1D2	281	P34982
TPMMNPFIYSLRNKD	OR1D4	281	P47884
TPMMNPFIYRLRNKD	OR1D5	281	P58170
PMLNPFIYSLRNKDM	OR1N1	281	Q8NGS0
NRSMHPYSEPVFSMQ	MN1	416	Q10571
PTHEDPNYLMANERM	RUFY3	56	Q7L099
APEMMKASPALAHYV	SNX13	666	Q9Y5W8
FHRMASFMPDPQNLE	SULT1C3	151	Q6IMI6
PRSDKQRFMEMYPAA	SRGAP1	311	Q7Z6B7
FQEMLLHKFPYRMVP	SNX8	116	Q9Y5X2
AQMPHMLFPNYPTKF	TLR10	336	Q9BXR5
VDFKYIAEPSMHSMP	CDC40	451	O60508
AMREIYDFMDDPKPH	PTDSS2	361	Q9BVG9
FPRDMKAMSPENQEY	RHOBTB2	646	Q9BYZ6
LKHMQFPPMYEENSR	SCG2	161	P13521
HINQEIFRMFPKDMP	ST8SIA5	141	O15466
MSSDFPHYNFRMPNI	RNF24	1	Q9Y225
RKPPLFNMNAMSALY	TAOK1	221	Q7L7X3
RKPPLFNMNAMSALY	TAOK2	221	Q9UL54
EEMLQRCKYSHMEPP	TEX45	426	Q8NA69
FYFQSMLHPVMRRNP	CHST11	31	Q9NPF2
PTNDMRYPMKSEKIH	TGDS	296	O95455
GRSNAMPHIKTYMRP	TDP1	486	Q9NUW8
PAVKMKYAENVPHNM	GTF2H1	201	P32780
NQFLHSPFLERPMDM	ZFHX4	2476	Q86UP3
TYLMKHMRKHNPPDL	ZNF384	446	Q8TF68
EPSMPYAMKISHQDF	PLEKHD1	96	A6NEE1
QPIQMKYMEHEERPK	HSPA4L	686	O95757
HPSEMRLYKNIPQMS	PITHD1	101	Q9GZP4
SYEMSQVKHKYMPPR	STPG2	361	Q8N412
MMYTQHPEQYEAPDK	TNPO2	621	O14787
FSIPFVEMKMRPYNH	TNR	1331	Q92752
FRKHLSIPMMDPFEQ	TTC41P	506	Q6P2S7
MHPRNKMPYIQNLSS	UNC5D	521	Q6UXZ4
RLMKNYSQPMPLFDR	ZDHHC11	101	Q9H8X9
RDHMQDSFLMQPEKY	ZMYM2	516	Q9UBW7
DPYPEEMMRQNHVLK	TJP1	1006	Q07157
NMKRHAMVDQPPVTY	ZNF430	96	Q9H8G1
QALVACPPMYHLMKF	USP10	431	Q14694
MPHYQRMHPTVKINN	ZNF462	941	Q96JM2
KPPYADIHPMRAIFM	STK4	221	Q13043
SNEPHIKRPMNAFMV	SOX5	551	P35711
MCHPNFEKMLEKYVP	TOGARAM1	1396	Q9Y4F4
RLMKNYSQPMPLFDR	ZDHHC11B	101	P0C7U3
EHRPLPKDYMMESVL	PRRT1B	181	A0A1B0GWB2
SMQGFPFYDKPMRIQ	SNRPA	71	P09012
PMFADQPDNIAHMKA	UGT2A2	401	P0DTE5
IHPQFLDRSLDMPFM	ZFHX3	2561	Q15911
YMYIHRPPTQMEAKS	KIAA1958	636	Q8N8K9
NYSIMLEPPEVKHAM	NEB	5701	P20929