Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentcortical actin cytoskeleton

AKAP13 SHROOM3 LLGL1 SHROOM2

5.19e-0593464GO:0030864
GeneOntologyCellularComponentcell cortex

AKAP13 SHROOM3 SPIRE2 LLGL1 SHROOM2 TRIP10

1.54e-04371466GO:0005938
GeneOntologyCellularComponentcortical cytoskeleton

AKAP13 SHROOM3 LLGL1 SHROOM2

1.85e-04129464GO:0030863
DomainCEP170_C

CEP170 CEP170B

5.18e-062432PF15308
DomainCEP170_C

CEP170 CEP170B

5.18e-062432IPR029300
DomainASD1

SHROOM3 SHROOM2

1.55e-053432PF08688
DomainASD1_dom

SHROOM3 SHROOM2

1.55e-053432IPR014800
DomainASD1

SHROOM3 SHROOM2

1.55e-053432PS51306
DomainASD2

SHROOM3 SHROOM2

3.10e-054432PF08687
DomainASD2

SHROOM3 SHROOM2

3.10e-054432PS51307
DomainShroom_fam

SHROOM3 SHROOM2

3.10e-054432IPR027685
DomainASD2_dom

SHROOM3 SHROOM2

3.10e-054432IPR014799
DomainhEGF

JAG2 NOTCH4

1.88e-0328432PF12661
DomainFHA

CEP170 CEP170B

1.88e-0328432SM00240
DomainFHA_DOMAIN

CEP170 CEP170B

2.31e-0331432PS50006
DomainFHA

CEP170 CEP170B

2.31e-0331432PF00498
DomainFHA_dom

CEP170 CEP170B

3.10e-0336432IPR000253
Domain-

CEP170 CEP170B

3.10e-03364322.60.200.20
DomainZnf_FYVE_PHD

SPIRE2 KMT2B MTF2

4.68e-03147433IPR011011
DomainSMAD_FHA_domain

CEP170 CEP170B

6.38e-0352432IPR008984
DomainLRR_6

CEP78 NLRX1

7.12e-0355432PF13516
Pubmed

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.

AKAP13 TERT NOTCH4

1.11e-061548323583980
Pubmed

A human-specific gene in microglia.

SIGLEC16 SIGLEC11

1.87e-06248216151003
Pubmed

SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.

SIGLEC16 SIGLEC11

1.87e-06248218629938
Pubmed

MLL4 binds TET3.

KMT2B TET3

1.87e-06248238579707
Pubmed

Genetic and functional analysis of SHROOM1-4 in a Chinese neural tube defect cohort.

SHROOM3 SHROOM2

1.87e-06248229423651
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

HEXA JAG2 AKAP13 SHROOM3 SPIRE2 KMT2B FHIP1B ZNF592 CEP170B NLRX1

2.20e-061105481035748872
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

JAG2 CEP170 AKAP13 SHROOM3 PLXDC2 SHROOM2 WDR11 TET3 MAN1C1 CEP170B GDE1

4.47e-061489481128611215
Pubmed

The role of Siglec-G on B cells in autoimmune disease and leukemia.

SIGLEC16 SIGLEC11

5.59e-06348238042621
Pubmed

The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells.

SIGLEC16 SIGLEC11

5.59e-06348224790146
Pubmed

SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.

SIGLEC16 SIGLEC11

5.59e-06348224859880
Pubmed

Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population.

SIGLEC16 SIGLEC11

5.59e-06348217572677
Pubmed

Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.

SIGLEC16 SIGLEC11

5.59e-06348223836061
Pubmed

The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle.

CEP170 CEP170B

5.59e-06348223087211
Pubmed

ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling.

JAG2 VPS4B NOTCH4

1.08e-053148337573008
Pubmed

Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activation.

SIGLEC16 SIGLEC11

1.12e-05448217912374
Pubmed

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo.

SIGLEC16 SIGLEC11

1.12e-05448220038598
Pubmed

CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity.

SIGLEC16 SIGLEC11

1.12e-05448220200274
Pubmed

Siglec-G regulates B1 cell survival and selection.

SIGLEC16 SIGLEC11

1.12e-05448220729333
Pubmed

Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice.

SIGLEC16 SIGLEC11

1.12e-05448224695850
Pubmed

Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells.

SIGLEC16 SIGLEC11

1.12e-05448225252961
Pubmed

Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction.

SIGLEC16 SIGLEC11

1.12e-05448230143587
Pubmed

Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.

SIGLEC16 SIGLEC11

1.12e-05448224600033
Pubmed

A new standard nomenclature for proteins related to Apx and Shroom.

SHROOM3 SHROOM2

1.12e-05448216615870
Pubmed

CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.

SIGLEC16 SIGLEC11

1.86e-05548219264983
Pubmed

Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice.

SIGLEC16 SIGLEC11

1.86e-05548225987743
Pubmed

B Lymphocyte-Derived CCL7 Augments Neutrophil and Monocyte Recruitment, Exacerbating Acute Kidney Injury.

SIGLEC16 SIGLEC11

1.86e-05548232737150
Pubmed

The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation.

SIGLEC16 SIGLEC11

1.86e-05548227548433
Pubmed

Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells.

SIGLEC16 SIGLEC11

1.86e-05548226947073
Pubmed

Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells.

JAG2 NOTCH4

1.86e-05548221602525
Pubmed

Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.

SIGLEC16 SIGLEC11

1.86e-05548236969253
Pubmed

A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing.

SIGLEC16 SIGLEC11

1.86e-05548221623346
Pubmed

Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G).

SIGLEC16 SIGLEC11

2.79e-05648214559209
Pubmed

Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.

SIGLEC16 SIGLEC11

2.79e-05648211986327
Pubmed

Human ligands of the Notch receptor.

JAG2 NOTCH4

3.90e-05748210079256
Pubmed

Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.

SIGLEC16 SIGLEC11

3.90e-05748228100677
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

JAG2 NOTCH4

3.90e-05748212846471
Pubmed

Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

JAG2 NOTCH4

5.19e-0584829858718
Pubmed

Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.

JAG2 NOTCH4

6.67e-05948211118901
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

JAG2 NOTCH4

6.67e-05948216245338
Pubmed

Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad.

JAG2 NOTCH4

6.67e-05948211944948
Pubmed

Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation.

SIGLEC16 SIGLEC11

6.67e-05948223374343
Pubmed

Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions.

SHROOM3 SHROOM2

6.67e-05948217666436
Pubmed

Notch signaling is essential for vascular morphogenesis in mice.

JAG2 NOTCH4

6.67e-05948210837027
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

JAG2 NOTCH4

8.33e-051048223665443
Pubmed

DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.

KMT2B TET3

8.33e-051048229276034
Pubmed

Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.

JAG2 NOTCH4

1.02e-041148216607638
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

JAG2 NOTCH4

1.02e-041148210878608
Pubmed

Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.

JAG2 NOTCH4

1.02e-041148212866128
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

JAG2 NOTCH4

1.22e-041248215465494
Pubmed

Collagen XIV is important for growth and structural integrity of the myocardium.

PLOD2 LOX

1.22e-041248222906538
Pubmed

CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.

SIGLEC16 SIGLEC11

1.44e-041348235921817
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

JAG2 NOTCH4

1.44e-041348211578869
Pubmed

Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis.

JAG2 NOTCH4

1.68e-041448228192800
Pubmed

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.

JAG2 NOTCH4

1.68e-041448218528438
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

JAG2 NOTCH4

1.68e-041448214757642
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

JAG2 NOTCH4

1.94e-041548212971992
Pubmed

The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver.

SIGLEC16 SIGLEC11

1.94e-041548222496360
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

JAG2 NOTCH4

2.21e-041648212617809
Pubmed

Notch gene expression during pancreatic organogenesis.

JAG2 NOTCH4

2.21e-041648210842072
Pubmed

Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice.

SHROOM3 LLGL1

2.21e-041648215037549
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

JAG2 NOTCH4

2.21e-041648217273555
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

JAG2 NOTCH4

2.50e-041748218694942
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

JAG2 NOTCH4

2.50e-041748215821257
Pubmed

A comprehensive family-based replication study of schizophrenia genes.

POM121L2 NOTCH4

2.50e-041748223894747
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

JAG2 NOTCH4

2.81e-041848218093989
Pubmed

Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci.

VARS2 NOTCH4

2.81e-041848219116923
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

JAG2 NOTCH4

2.81e-041848215689374
Pubmed

Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.

JAG2 NOTCH4

3.14e-041948216518823
Pubmed

Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.

JAG2 NOTCH4

3.85e-042148228656980
Pubmed

Conversion of biliary system to pancreatic tissue in Hes1-deficient mice.

JAG2 NOTCH4

3.85e-042148214702043
Pubmed

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.

JAG2 NOTCH4

4.63e-042348214701881
Pubmed

Rbpj regulates development of prosensory cells in the mammalian inner ear.

JAG2 NOTCH4

5.05e-042448221420948
Pubmed

Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.

SIGLEC16 SIGLEC11

5.05e-042448215331780
Pubmed

Proteomic characterization of the human centrosome by protein correlation profiling.

CEP170 CEP78

5.93e-042648214654843
Pubmed

Notch signaling controls liver development by regulating biliary differentiation.

JAG2 NOTCH4

5.93e-042648219369401
Pubmed

Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.

JAG2 NOTCH4

7.39e-042948224971735
Pubmed

EGFL7 is expressed in bone microenvironment and promotes angiogenesis via ERK, STAT3, and integrin signaling cascades.

JAG2 NOTCH4

7.39e-042948224909139
Pubmed

Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.

JAG2 NOTCH4

7.39e-042948225535917
Pubmed

Notch signaling in stomach epithelial stem cell homeostasis.

JAG2 NOTCH4

7.39e-042948221402740
Pubmed

Notch signaling regulates ovarian follicle formation and coordinates follicular growth.

JAG2 NOTCH4

7.92e-043048224552588
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

CUL7 LLGL1 CEP78 WDR11

9.17e-0431348438270169
Pubmed

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.

JAG2 NOTCH4

1.02e-033448221311046
Pubmed

A genome-wide association study (GWAS) for bronchopulmonary dysplasia.

CEP170 PLXDC2

1.02e-033448223897914
Pubmed

Notch signaling regulates smooth muscle differentiation of epicardium-derived cells.

JAG2 NOTCH4

1.08e-033548221252157
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

HEXA CUL7 KMT2B SHROOM2

1.10e-0332948417474147
Pubmed

Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification.

JAG2 NOTCH4

1.20e-033748224673559
Pubmed

Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells.

JAG2 NOTCH4

1.20e-033748227631609
Pubmed

Functional proteomics mapping of a human signaling pathway.

KMT2B MTF2 ZNF592 MAN1C1 ZNF587B

1.31e-0359148515231748
CytobandEnsembl 112 genes in cytogenetic band chr15q25

AKAP13 ST20-AS1 ZNF592

6.40e-04160483chr15q25
GeneFamilyZinc fingers CXXC-type

KMT2B TET3

1.51e-0412282136
GeneFamilyCD molecules|C2-set domain containing|Sialic acid binding Ig like lectins

SIGLEC16 SIGLEC11

8.53e-0428282745
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

SIGLEC16 SIGLEC11

1.74e-0340282592
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

AKAP13 TRIP10

2.81e-0351282870
GeneFamilyPHD finger proteins

KMT2B MTF2

8.52e-039028288
CoexpressionGSE26030_UNSTIM_VS_RESTIM_TH17_DAY5_POST_POLARIZATION_UP

HEXA AKAP13 VARS2 PLXDC2 CEP170B

1.80e-05181475M8579
CoexpressionGSE40443_INDUCED_VS_TOTAL_TREG_UP

MIDN CUL7 LLGL1 PLXDC2 PLOD2

2.84e-05199475M9198
CoexpressionGSE3039_NKT_CELL_VS_ALPHABETA_CD8_TCELL_UP

CCDC90B CUL7 LLGL1 LOX CEP170B

2.91e-05200475M6429
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SIGLEC11 MIDN KLHL1 PLXDC2 USH2A TET3

4.29e-0818647623b8d51d20b05795a73892d3e20e0f9b6a207820
ComputationalGenes in the cancer module 175.

TERT PLOD2 TRIP10

2.25e-0454243MODULE_175
ComputationalGenes in the cancer module 120.

TERT PLOD2 TRIP10

5.06e-0471243MODULE_120
Diseasechronic kidney disease (implicated_via_orthology)

SHROOM3 TERT

1.62e-0412472DOID:784 (implicated_via_orthology)
Diseaseinterstitial lung disease

AKAP13 TERT NOTCH4

1.69e-0467473EFO_0004244
DiseaseX-11470 measurement

VARS2 NOTCH4

4.17e-0419472EFO_0021241
DiseaseCarcinoma, Pancreatic Ductal

JAG2 NOTCH4

6.70e-0424472C0887833
Diseasebreast cancer, lung cancer

POM121L2 TERT

7.28e-0425472MONDO_0007254, MONDO_0008903
Diseaseeosinophil percentage of leukocytes

AKAP13 KMT2B MTF2 TERT TET3 GGT5

1.14e-03746476EFO_0007991
Diseaselower urinary tract symptom, benign prostatic hyperplasia

WDR11 TERT

1.19e-0332472EFO_0000284, EFO_0008008
Diseasethyroid carcinoma

TERT DBX1

1.77e-0339472EFO_0002892
Diseasebronchopulmonary dysplasia

CEP170 PLXDC2

2.35e-0345472MONDO_0019091
Diseaseserum albumin measurement

SHROOM3 LLGL1 KCNT2 TERT NOTCH4

2.45e-03592475EFO_0004535
Diseaserheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement

KMT2B TET3 CEP170B

2.53e-03170473EFO_0000685, EFO_0007791, EFO_0007837
Diseasehair colour measurement

AKAP13 SHROOM3 SPIRE2 PLXDC2 ARL17A

2.88e-03615475EFO_0007822
Diseaseretinal drusen

CCDC185 KCNT2

3.01e-0351472EFO_1001155

Protein segments in the cluster

PeptideGeneStartEntry
LGRHLGRWSPSSVPS

CCDC185

176

Q8N715
WFLVSSGGTRHRLPR

CEP170

6

Q5SW79
WASRSLHPLPGSRDR

CCSMST1

21

Q4G0I0
RSLSPFRRHSWGPGK

AKAP13

1556

Q12802
TWKGPERLAHGSPFR

CAMTA2

696

O94983
WKGGRSHPFLPHSSR

ARL17A

116

Q8IVW1
PWRTAERAKRHRGFP

CEP78

391

Q5JTW2
IRRGHRPRGSLDWPS

CEP170B

1031

Q9Y4F5
GDRWVSRPRGHFSPA

CCDC90B

16

Q9GZT6
KRTRTGRSWPAAIPH

MTF2

481

Q9Y483
FTWKGHERLSPRTGP

LLGL1

566

Q15334
WLSRLASRGPGHRIP

FHIP1B

6

Q8N612
FTKDPGRSPGRPAHW

JAG2

1201

Q9Y219
PRPKGRNRSHDWSSL

CUL7

1116

Q14999
GTFSWPLAARGKPRR

DBX1

166

A6NMT0
GWGRPRSFPRAPTVH

KRT23

21

Q9C075
KRRWATRGPAHPAFA

HRES1

161

P13985
GPSYPTRATRKRRHW

KMT2B

1281

Q9UMN6
HDPKYWRRSTRLPNG

KMT2B

1511

Q9UMN6
QWARRLSRKGPKHSG

KCNT2

1016

Q6UVM3
HLPRASWGSGFRRAL

NLRX1

6

Q86UT6
SPRKGWSFMHPGRLT

PLOD2

701

O00469
HRPWSLSHTGDGKPR

GDE1

226

Q9NZC3
GQRWRLGDPRSHPKL

GGT5

331

P36269
PSSWASPRRRKGGLR

MAN1C1

96

Q9NR34
GVTAGRPRPTARHWF

LOX

111

P28300
GSWPRPYLTGKRHTL

HEXA

76

P06865
RKARRDARGPYHWSP

MIDN

406

Q504T8
PPFWGLRHSRGLPRF

VARS2

11

Q5ST30
GSRKAHVRWEAPFRP

USH2A

2341

O75445
RWPAMKFRRGSGHPA

PLXDC2

496

Q6UX71
TDRPWRSAHPGSLGK

SHROOM2

366

Q13796
SWRPRPSSAHVGLRS

SHROOM3

956

Q8TF72
REHGALWLPPGFTRR

NOTCH4

1476

Q99466
RPGPLKRSLHSWGSD

POM121L2

211

Q96KW2
RGPGRSRTKRWPFGK

TRIP10

311

Q15642
SRSHSRGREGLRPPW

NKAPL

41

Q5M9Q1
FPHLFTGKRTPWRGI

VPS4B

156

O75351
RPSRRGYSSHHGPSW

ZC3H3

56

Q8IXZ2
ESGPGWLHKARRPTR

ST20-AS1

86

Q8NBB2
RPRAGSAHVWRPGSR

SPIRE2

471

Q8WWL2
SSLPSGRWGRPEAHR

ZNF592

956

Q92610
ASHSGGRLRGKPWSP

TET3

1501

O43151
KPSLSYHQRFGRPRW

ZNF587B

366

E7ETH6
PTHRSWVRKIRFAPG

WDR11

746

Q9BZH6
FSWTGAALSPRRTRP

SIGLEC11

191

Q96RL6
WAHPGRTRGPSDRGF

TERT

256

O14746
RVLSSSHPWGPRTLG

SIGLEC16

276

A6NMB1
RLRWKLFSHPSPSTG

KLHL1

16

Q9NR64
WARGSRPRHASLPSS

GRIN2C

1071

Q14957