Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainPecanex_C

PCNX1 PCNX3

2.68e-054402PF05041
DomainPecanex

PCNX1 PCNX3

2.68e-054402IPR007735
Domain-

CNNM1 CNGA2

4.74e-03484022.60.120.10
DomainRmlC-like_jellyroll

CNNM1 CNGA2

5.34e-0351402IPR014710
Pubmed

Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.

ANTXR1 FBN2 LYRM4

5.44e-062941321998595
Pubmed

The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.

TPR GNE CSPG4 DHX30 HDLBP

3.93e-0532541536168628
Pubmed

Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.

TPR DHX30 HDLBP

6.91e-056741329357390
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

ASPM TPR FLG2 DHX30

1.66e-0423441436243803
Pubmed

Localization of the mouse glucocorticoid receptor-interacting protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysis.

CPS1 HDLBP

1.82e-04174129250876
Pubmed

A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.

FREM3 CSPG4

2.05e-041841214730302
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCNX1 ZNF263 B4GALNT4 PCNX3 FAM83F CSPG4 DHX30

2.80e-04110541735748872
Pubmed

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.

TPR FLG2 EIF4A3 DHX30 POLR1C HDLBP

2.99e-0478641629128334
Pubmed

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

MPV17 PLD6 CPS1 GTPBP3 LYRM4 PNPO DHX30

3.31e-04113641734800366
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

GNE EIF4A3 DHX30 POLR1C HDLBP

3.98e-0453441535032548
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

TPR FLG2 FAM83F EIF4A3 DHX30 POLR1C HDLBP

6.07e-04125741736526897
Pubmed

The layered structure of human mitochondrial DNA nucleoids.

CPS1 DHX30

6.58e-043241218063578
Pubmed

NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer.

FLG2 EIF4A3 DHX30

8.17e-0415541333838681
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

ASPM FLG2 EIF4A3 DHX30 POLR1C HDLBP

9.10e-0497141633306668
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ASPM TPR GNE EIF4A3 DHX30 POLR1C HDLBP

9.36e-04135341729467282
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

TPR FLG2 EIF4A3 DHX30 POLR1C

1.03e-0366041532780723
ToppCellBasal_cells-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

CNNM1 B4GALNT4 FAM83F CYP2W1 NECTIN1

4.33e-07166415aea2ae12e4746149ebc6da063ef694381c098f80
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ADAMTSL1 FBN2 CPS1 FLG2 FFAR2

9.59e-07195415d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ADAMTSL1 FBN2 CPS1 FLG2 FFAR2

9.59e-0719541519853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FBN2 TENM4 CSPG4 STAC3

1.79e-05170414ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCelldroplet-Lung-LUNG-30m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FFAR2 CYP2W1 NECTIN1 PNPO

1.79e-05170414ece7c20e89c190a7ec68032b6c2efeb458c43f9a
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ASPM FAM83F REM2 ZNF551

2.33e-05182414d1c3cc2942faec7527a3c25869fd65c17899e5e4
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ASPM FAM83F REM2 ZNF551

2.33e-0518241492f83f29e358000cd86a709eb8b6199761ffe8bd
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft-Tuft_L.0.7.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ASPM FAM83F REM2 ZNF551

2.33e-0518241402baca9a72c7b559c3e452693b3b134af804c868
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-immature_innate_lymphoid_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANKRD35 B4GALNT4 FREM3 FFAR2

2.59e-05187414fae08f34dc4b15352bd4d10bc6c924fe119b5d5e
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANKRD35 B4GALNT4 FREM3 FFAR2

2.59e-05187414e6b140b9fb582abf07aa6ea9bc437de3ba0d6de1
DrugB-08

FBN2 GNE

9.48e-063412CID016086421
DiseaseFEV change measurement, response to zileuton

PCNX1 CPS1

5.01e-0425392EFO_0005921, EFO_0007676
Diseaselifestyle measurement, maximum cigarettes per day measurement

PCNX1 ADAMTSL1 FREM3

5.65e-04122393EFO_0009264, EFO_0010724
Diseasemitochondrial metabolism disease (implicated_via_orthology)

MPV17 GTPBP3

9.85e-0435392DOID:700 (implicated_via_orthology)
DiseaseCombined oxidative phosphorylation deficiency

GTPBP3 LYRM4

1.10e-0337392cv:C4540031

Protein segments in the cluster

PeptideGeneStartEntry
VRGNGFRHARNVDRV

ANTXR1

241

Q9H6X2
QTISRIFHVARGGRR

CSPG4

1021

Q6UVK1
RRGQRLRSGVHVVVT

GTPBP3

241

Q969Y2
GRRAREVAFIHIQRE

AJM1

891

C9J069
RQFTVRALHSLGVGR

CYP2W1

126

Q8TAV3
RHLQQALSRRRRGGQ

ANKRD35

236

Q8N283
ALSRRRRGGQRLVQH

ANKRD35

241

Q8N283
VSRANVIQRRGRAGR

DHX30

771

Q7L2E3
QSVYRGIRVRRHIQH

ASPM

2101

Q8IZT6
RGNVVRRVFGRIRRF

ARHGAP36

151

Q6ZRI8
LVREDRGGRRVHRFQ

A1BG

336

P04217
HFRLRVVVQDVGTRG

DCHS1

981

Q96JQ0
TVRRRQGTTHGQRGD

FLG2

1306

Q5D862
LVGAQRRRRAVGLAV

FFAR2

211

O15552
NNRELYIHRIGRSGR

EIF4A3

356

P38919
IQTRRQRKLHFVVGG

ADAMTSL1

871

Q8N6G6
STFRRQAVRRRHNAG

PCNX1

786

Q96RV3
SVRRTQAIRRRHNAG

PCNX3

581

Q9H6A9
GQTNRLHDRIVFRRG

PNPO

221

Q9NVS9
RRTSINVVRHLGIVG

CPS1

681

P31327
RQIGRETGENVLHVR

GNE

321

Q9Y223
RDLGVIRRQVHIGQL

LYRM4

61

Q9HD34
ASRVRRRGQQDVLRG

FBN2

71

P35556
VREHFQLLVRIRGGA

FREM3

286

P0C091
LGRAVQLLHQRGVRV

PLD6

106

Q8N2A8
QGLESRIQHFVRRGR

PUS3

421

Q9BZE2
QLVERRGLQEHQRGR

MPV17

36

P39210
RSRVVLGEFGVRNVH

POLR1C

11

O15160
FRIRNIRVRSVTGVG

FAM83F

216

Q8NEG4
VHLGLVRQGRALRQR

B4GALNT4

31

Q76KP1
GRRVNTRARNHVGRV

ANKDD1A

36

Q495B1
QGRSGFRRIVRLVGI

CNGA2

61

Q16280
QEQARRVQAVRGRGT

CNNM1

266

Q9NRU3
TLRQGVRGRQFNRQR

TPR

2331

P12270
VRGRQFNRQRGVSHA

TPR

2336

P12270
RQIFNLIRHRRVHTG

ZNF551

401

Q7Z340
RGQVTVFGRRLRVHN

TENM4

1821

Q6N022
EGAVRQIRLRRGRNH

REM2

271

Q8IYK8
QIRLRRGRNHAGGQR

REM2

276

Q8IYK8
QRFHRTIIGQKGERI

HDLBP

516

Q00341
HRVTRSFVGNREIGQ

STAC3

311

Q96MF2
IRVQGREFRAHRAVL

ZBTB22

61

O15209
RELGRLRQQVTNHGR

ZNF263

121

O14978
VGGIVVALRRRRHTF

NECTIN1

371

Q15223