Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	PDZ	MAGI2 IL16 SCRIB MAST3	1.84e-03	141	69	4	PF00595
Domain	PDZ	MAGI2 IL16 SCRIB MAST3	2.20e-03	148	69	4	SM00228
Domain	-	MAGI2 IL16 SCRIB MAST3	2.31e-03	150	69	4	2.30.42.10
Domain	PDZ	MAGI2 IL16 SCRIB MAST3	2.36e-03	151	69	4	PS50106
Domain	PDZ	MAGI2 IL16 SCRIB MAST3	2.42e-03	152	69	4	IPR001478
Pubmed	Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.	FAM90A17 FAM90A23 FAM90A8 FAM90A16	1.81e-07	23	76	4	18602769
Pubmed	Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.	FAM90A17 FAM90A23 FAM90A8 FAM90A16	2.57e-07	25	76	4	17684299
Pubmed	A new allele of Gli3 and a new mutation, circletail (Crc), resulting from a single transgenic experiment.	GLI3 SCRIB	4.71e-06	2	76	2	12112872
Pubmed	Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription.	ATN1 RUNX1T1	4.71e-06	2	76	2	10973986
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	SYNE1 MCM9 HEATR5B	1.11e-05	20	76	3	21689717
Pubmed	Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation.	MAGI2 NLGN1	1.41e-05	3	76	2	20534458
Pubmed	Netrin 1 regulates ventral tangential migration of guidepost neurons in the lateral olfactory tract.	GLI3 DCC	2.82e-05	4	76	2	16439477
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MAGI2 TRIL SYNE1 FAM91A1 ZYG11B NLGN1 SCRIB	3.12e-05	407	76	7	12693553
Pubmed	Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.	MAGI2 ATN1	7.03e-05	6	76	2	9647693
Pubmed	BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor.	HPS1 MON1A	9.83e-05	7	76	2	23084991
Pubmed	Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.	IL16 OXER1 FHIT	1.52e-04	47	76	3	18821565
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	VWA5B2 DHX15 FBXW9 SUSD6 GAA B4GALT3	1.65e-04	371	76	6	15747579
Pubmed	Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors.	DAG1 GRM6	1.68e-04	9	76	2	30282023
Pubmed	Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes.	MAGI2 SCRIB	1.68e-04	9	76	2	20534871
Pubmed	Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site.	IL16 STAMBP	2.10e-04	10	76	2	19906316
Pubmed	Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.	RASIP1 PYROXD2	2.56e-04	11	76	2	24586186
Pubmed	Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.	HPS1 DCC HEATR5B	3.46e-04	62	76	3	17975119
Pubmed	Gene variants associated with ischemic stroke: the cardiovascular health study.	HPS1 DCC HEATR5B	3.62e-04	63	76	3	19023099
Pubmed	Duplication and selection in the evolution of primate beta-defensin genes.	DEFB108A DEFB108B	4.22e-04	14	76	2	12734011
Pubmed	Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.	GLI3 DAG1	4.22e-04	14	76	2	19783738
Pubmed	Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.	MAGI2 ARRDC2	4.86e-04	15	76	2	23236378
Pubmed	TIF1gamma controls erythroid cell fate by regulating transcription elongation.	RUNX1T1 TAL1	7.05e-04	18	76	2	20603019
Pubmed	Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.	ATN1 GLI3	7.05e-04	18	76	2	14645126
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF469 IL16 HMCN2 ATN1 VPS72 GLI3 SCRIB BRD1 PLEKHN1	7.24e-04	1116	76	9	31753913
Pubmed	A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.	IL16 TAL1	7.87e-04	19	76	2	34360789
Pubmed	ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.	BRD1 TAL1	8.73e-04	20	76	2	16407974
Pubmed	DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation.	DAG1 DCC	9.63e-04	21	76	2	33871356
Pubmed	Schwann cell myelination requires integration of laminin activities.	DAG1 LAMC3	9.63e-04	21	76	2	22767514
Pubmed	DOT1L regulates dystrophin expression and is critical for cardiac function.	DAG1 DOT1L	9.63e-04	21	76	2	21289070
Pubmed	NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.	NYAP1 WASF1	1.06e-03	22	76	2	21946561
Pubmed	Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia.	GLI3 TAL1	1.06e-03	22	76	2	28432216
Pubmed	Renal collecting system growth and function depend upon embryonic γ1 laminin expression.	DAG1 LAMC3	1.16e-03	23	76	2	21903675
Pubmed	Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development.	DAG1 GRM6	1.37e-03	25	76	2	28760865
Pubmed	Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.	RASIP1 SYNE1 ALAS1	1.47e-03	102	76	3	21926972
Pubmed	Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling.	GLI3 DCC	1.48e-03	26	76	2	35927240
Pubmed	Retinoic acid deficiency impairs the vestibular function.	NOXO1 GLI3	1.48e-03	26	76	2	23536097
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	VWA5B2 SYNE1 GLI3 MCM9	1.73e-03	233	76	4	37704626
Pubmed	The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap.	GLI3 DCC	1.84e-03	29	76	2	25336744
Pubmed	The zinc-finger transcription factor GLI3 is a regulator of precerebellar neuronal migration.	GLI3 DCC	2.10e-03	31	76	2	30470704
Cytoband	8p23.1	DEFB108A FAM90A17 FAM90A23 FAM90A8 FAM90A16	6.07e-06	154	76	5	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	DEFB108A FAM90A17 FAM90A23 FAM90A8 FAM90A16	4.54e-05	234	76	5	chr8p23
Cytoband	19p13.11	ANKLE1 ARRDC2 MAST3	2.49e-04	73	76	3	19p13.11
GeneFamily	PDZ domain containing	MAGI2 IL16 SCRIB MAST3	4.59e-04	152	43	4	1220
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SYNE1 NLGN1 INKA2 MAST3 KCNH3	9.53e-06	175	72	5	ff0789f5913c9f3c49159e40b1ec3d2ff175ec9f
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SYNE1 NLGN1 INKA2 MAST3 KCNH3	9.53e-06	175	72	5	21f8f11a8b874d4f7c47931010a2535f2a5a3373
ToppCell	droplet-Lung-nan-21m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGI2 SAMD10 DOT1L PLEKHN1 KCNH3	1.06e-05	179	72	5	d78eacf47847a50888dd16c35bed9b7afc80010f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI2 SYNE1 GLI3 NLGN1 FBXO17	1.28e-05	186	72	5	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MAGI2 TRIL GLI3 NLGN1 RUNX1T1	1.61e-05	195	72	5	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	DHX15 ZNF469 SAMD10 HPS1 HPDL	1.65e-05	196	72	5	09d197b321ff9f13c0672ea059c850845b0dbbd5
Disease	Headache, type 2 diabetes mellitus	TSKU NLGN1 INKA2	1.92e-05	23	67	3	HP_0002315, MONDO_0005148
Disease	DNA methylation	DHX15 VPS72 GLI3 FAM91A1 NOCT BRD1 DCC FHIT	1.18e-04	656	67	8	GO_0006306
Disease	taste liking measurement	MAGI2 RASIP1 DAG1 DCC FHIT KCNH3	2.52e-04	388	67	6	EFO_0010155
Disease	migraine disorder, type 2 diabetes mellitus	GLI3 NLGN1 INKA2	3.49e-04	60	67	3	MONDO_0005148, MONDO_0005277
Disease	alcohol consumption measurement	DHX15 MAGI2 RASIP1 GLI3 SERGEF LAMC3 DCC RUNX1T1 FHIT TAL1	4.70e-04	1242	67	10	EFO_0007878
Disease	S-7-hydroxywarfarin to S-warfarin ratio measurement	MAGI2 IGFN1 FHIT	8.41e-04	81	67	3	EFO_0803334
Disease	response to anticonvulsant	MAGI2 PYROXD2 FHIT	9.67e-04	85	67	3	GO_0036277
Disease	neuroticism measurement	DHX15 DAG1 ALAS1 NOCT DCC FHIT TAL1 KCNH3	1.03e-03	909	67	8	EFO_0007660
Disease	arginine measurement	HPS1 PYROXD2	1.25e-03	23	67	2	EFO_0020990
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	MAGI2 NIM1K NLGN1 FHIT TAL1	1.43e-03	364	67	5	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	Postural instability	FHIT INKA2	1.47e-03	25	67	2	HP_0002172
Disease	Brain Diseases	LAMC3 STAMBP	1.47e-03	25	67	2	C0006111
Disease	unipolar depression	MAGI2 TRIL OXER1 MCM9 NLGN1 NOCT DCC FHIT TAL1	1.57e-03	1206	67	9	EFO_0003761
Disease	gastroesophageal reflux disease	TSKU MON1A DCC	1.59e-03	101	67	3	EFO_0003948
Disease	unipolar depression, depressive symptom measurement	DCC FHIT	1.59e-03	26	67	2	EFO_0003761, EFO_0007006
Disease	osteoarthritis	TSKU VPS72 DOT1L FHIT	1.65e-03	222	67	4	MONDO_0005178
Disease	eye measurement	RASIP1 ZNF469	1.72e-03	27	67	2	EFO_0004731
Disease	Encephalopathies	LAMC3 STAMBP	1.72e-03	27	67	2	C0085584
Disease	bipolar disorder (is_implicated_in)	SYNE1 BRD1	1.98e-03	29	67	2	DOID:3312 (is_implicated_in)
Disease	body weight	CACNA1B NLGN1 SCRIB MON1A DOT1L DCC RUNX1T1 FHIT TAL1	2.12e-03	1261	67	9	EFO_0004338

Protein segments in the cluster

Peptide	Gene	Start	Entry
VATEHNPVRPLRRCP	FAM229A	86	H3BQW9
DVHTPPGCTRRPLNI	BRD1	386	O95696
PAGCEPRSRTAIIVP	B4GALT3	116	O60512
GREPVGPCRHLPVST	ANKLE1	346	Q8NAG6
RAPVECPSLGPVPHR	ATN1	846	P54259
EVVPCTPSHVGRPRL	DOT1L	746	Q8TEK3
NCPLLTIPGRTHPVE	DHX15	306	O43143
ARPPLERGHSTEIPV	CACNA1B	1951	Q00975
CLPLGHQPRIESTTP	DEFB108B	56	Q8NET1
LRIPPVGPSILHCRV	ARRDC2	261	Q8TBH0
PDILPRHCTVRAGPE	RASIP1	431	Q5U651
ECVRVPRGGIPPRAH	CPSF7	176	Q8N684
VQLVLAPHREGPCPR	KCNH3	906	Q9ULD8
VKPTHSRPEGGCREV	FAM90A23	226	A8MXZ1
TGVSHLCPEPPETRV	FAM47C	601	Q5HY64
SRVSHLCPEPPETGV	FAM47C	721	Q5HY64
IPTACVRPTHPLRSF	DCC	1331	P43146
IRVHVPTDPPRTICT	FBXW9	411	Q5XUX1
PGVALPPVHAPRRCS	GLI3	966	P10071
RTVPCTTRPHKEGEV	MAGI2	136	Q86UL8
GIRQLHVPCRGPVPD	NMUR1	201	Q9HB89
VCGRDLAPLPRTQPH	INKA2	111	Q9NTI7
PVVHCPSHIIPVRVA	ALAS1	521	P13196
EHPSKRPCTISPGQR	RUNX1T1	261	Q06455
RPVALECVARGHPSP	HMCN2	1641	Q8NDA2
IRPVSSCTPQHIGPA	FAM91A1	511	Q658Y4
GSCRHLQFIPVVPPR	DAG1	711	Q14118
IERTHPGLPKGVTCP	C9orf131	741	Q5VYM1
QVRPAVLPTRCPHPG	KLK15	121	Q9H2R5
VLPTRCPHPGEACVV	KLK15	126	Q9H2R5
SHCDPGPVPIIVSRH	IL16	426	Q14005
VKPTHSRPEGGCREV	FAM90A17	226	P0DV74
SIHPHEVVLRTACPP	NLGN1	786	Q8N2Q7
PPHVSEPCHRLIRGV	NIM1K	291	Q8IY84
VKPTHSRPEGGCREV	FAM90A16	226	P0DV73
VPIIPLCPEHSCRGR	OXER1	11	Q8TDS5
AALGCSVPVPPVRVR	HPDL	96	Q96IR7
CPVIIHPGRSSRAPF	PTER	196	Q96BW5
APHSISRCPRPLGAV	PANO1	11	I0J062
VKPTHSRPEGGCREV	FAM90A8	226	A6NJQ4
SHVPPRSLVTRCRPV	FBXO17	31	Q96EF6
HVCVRRGPGPREAVP	MON1A	46	Q86VX9
VVPGHVLVCPLRPVE	FHIT	31	P49789
SPRPEEPIEHVTACL	HEATR5B	1601	Q9P2D3
PNHTGCRPTPVVRLS	GRM6	566	O15303
CLPLGHQPRIESTTP	DEFB108A	56	A8MXU0
VIRGPPRCREPGTAH	FRMD6-AS1	156	P0C7T7
HPGRPRAVPTQCDVP	GAA	71	P10253
SPVCGSLRPPIVIHS	MAST3	941	O60307
AIPPRVVVPLAETHC	IGFN1	306	Q86VF2
VPSVERQPPHRRPCL	FAM90A20P	356	A6NIJ5
QTLVPHCPVPSGPRR	HPS1	336	Q92902
HCPVPSGPRRIFLDA	HPS1	341	Q92902
VKPTHSRPEGGCREV	FAM90A5P	226	A8MXJ8
DLRTDCPSTHPPIRV	NOCT	131	Q9UK39
VKPTHSRPEGGCREV	FAM90A24P	226	P0C7X0
PRKSGTPPCRRQHTV	NYAP1	821	Q6ZVC0
SGLPVCPELVREHIP	MCM9	101	Q9NXL9
EEPVLVPRPHQVSRC	HHLA1	426	C9JL84
PHGPRRCVVPQAIEL	SERGEF	136	Q9UGK8
SPHCPLTTPRREIVV	TRMT44	191	Q8IYL2
CLRAVTHREGAPPLP	PLEKHN1	311	Q494U1
RDPVRDTPGTCHVTL	SYNE1	1091	Q8NF91
HRVPTTELCRPPGPA	TAL1	86	P17542
VKPTHSRPEGGCREV	FAM90A12P	226	A8MX19
VKPTHSRPEGGCREV	FAM90A13P	226	P0C7W8
VSAESIPCHLPRTPG	SAMD10	46	Q9BYL1
PESPGPLRQRHVACL	SCRIB	851	Q14160
HPRPCRDPLTAGSVI	SUSD6	56	Q92537
RPRGCVDSVPHPTTE	NOXO1	361	Q8NFA2
VVKGHRPELPPVCRA	RIPK4	236	P57078
VKPTHSRPEGGCREV	FAM90A15P	226	P0C7V4
SLEKHIVRHGRPPPC	ZYG11B	721	Q9C0D3
GLPSHRPVIELCIPS	PYROXD2	426	Q8N2H3
TALITPGPVRHCQIP	TMEM39A	51	Q9NV64
CHTTVRPAKPPVVDR	STAMBP	221	O95630
PVAPRDHCAGLVTLP	TRIL	671	Q7L0X0
RPVDPVTHPIRGCEL	ZNF469	3501	Q96JG9
SLKSGPRQERVHPPC	ZBTB42	191	B2RXF5
AVPPQAPRCHVVIRG	VWA5B2	831	Q8N398
ARAAPVCETVPVHPL	WASF1	401	Q92558
VPVREVCPVTHRPAL	VPS72	286	Q15906
RFTCPSLALHPREPV	WDR25	426	Q64LD2
PRRPGSSPKVALHCV	TSKU	326	Q8WUA8
HPVVRSAAVRPVCLP	TMPRSS6	676	Q8IU80
IPESREVVCTHCPPG	LAMC3	766	Q9Y6N6