Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	KN_motif	KANK4 KANK3	3.24e-05	4	44	2	IPR021939
Domain	KN_motif	KANK4 KANK3	3.24e-05	4	44	2	PF12075
Domain	Ank	KANK4 ANKRD17 ANKHD1 KANK3	2.00e-03	228	44	4	PF00023
Domain	ANK	KANK4 ANKRD17 ANKHD1 KANK3	2.84e-03	251	44	4	SM00248
Domain	ANK_REPEAT	KANK4 ANKRD17 ANKHD1 KANK3	2.92e-03	253	44	4	PS50088
Domain	Ankyrin_rpt-contain_dom	KANK4 ANKRD17 ANKHD1 KANK3	2.96e-03	254	44	4	IPR020683
Domain	ANK_REP_REGION	KANK4 ANKRD17 ANKHD1 KANK3	2.96e-03	254	44	4	PS50297
Domain	DNA/RNA_helicase_DEAH_CS	CHD8 DHX37	3.07e-03	35	44	2	IPR002464
Domain	Ankyrin_rpt	KANK4 ANKRD17 ANKHD1 KANK3	3.31e-03	262	44	4	IPR002110
Domain	KH_1	ANKRD17 ANKHD1	3.61e-03	38	44	2	PF00013
Domain	DEAH_ATP_HELICASE	CHD8 DHX37	3.61e-03	38	44	2	PS00690
Domain	KH	ANKRD17 ANKHD1	4.00e-03	40	44	2	SM00322
Domain	KH_dom	ANKRD17 ANKHD1	4.00e-03	40	44	2	IPR004087
Domain	KH_TYPE_1	ANKRD17 ANKHD1	4.40e-03	42	44	2	PS50084
Domain	KH_dom_type_1	ANKRD17 ANKHD1	4.82e-03	44	44	2	IPR004088
Domain	TPR_8	DNAJC3 CTR9	6.93e-03	53	44	2	PF13181
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	TMEFF1 ANKRD17 SNRNP70 TCOF1 CTR9 PPM1G	8.56e-07	251	45	6	28077445
Pubmed	Cone dystrophy in patient with homozygous RP1L1 mutation.	PCDH15 RP1L1	1.64e-06	2	45	2	25692141
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ANKRD17 CHD8 SNRNP70 ANKHD1 TCOF1 DHX37 PPM1G RSF1	1.73e-06	653	45	8	22586326
Pubmed	Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability.	ANKRD17 ANKHD1	4.91e-06	3	45	2	31661072
Pubmed	Kank proteins: a new family of ankyrin-repeat domain-containing proteins.	KANK4 KANK3	9.81e-06	4	45	2	17996375
Pubmed	Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK.	ANKRD17 ANKHD1	9.81e-06	4	45	2	14557257
Pubmed	Kank proteins: structure, functions and diseases.	KANK4 KANK3	9.81e-06	4	45	2	19554261
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ANKRD17 CHD8 AP3B1 ANKHD1 CTR9 DHX37 ZXDB	1.89e-05	650	45	7	38777146
Pubmed	Muted, a new mutant affecting coat colour and otoliths of the mouse, and its position in linkage group XIV.	FOXQ1 AP3B1	2.45e-05	6	45	2	5367369
Pubmed	Global landscape of HIV-human protein complexes.	ANKRD17 ZNF579 ANKHD1 DNAJC3 EML3 PPM1G	2.63e-05	457	45	6	22190034
Pubmed	Molecular markers near two mouse chromosome 13 genes, muted and pearl, which cause platelet storage pool deficiency (SPD).	FOXQ1 AP3B1	3.42e-05	7	45	2	7719021
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	CHD8 ZNF579 SNRNP70 TCOF1 CTR9 RSF1	4.49e-05	503	45	6	16964243
Pubmed	UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.	ZNF579 SNRNP70 ANKHD1 PPM1G	4.90e-05	155	45	4	34921745
Pubmed	Human transcription factor protein interaction networks.	ANKRD17 CHD8 PAGR1 SALL2 FOXQ1 SNRNP70 ANKHD1 DHX37 PPM1G	7.57e-05	1429	45	9	35140242
Pubmed	Strain background effects and genetic modifiers of hearing in mice.	PCDH15 TUB	8.94e-05	11	45	2	16579977
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	CHD8 SNRNP70 TCOF1 DHX37	1.24e-04	197	45	4	20811636
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	CHD8 SALL2 SNRNP70 DHX37 RSF1	1.86e-04	411	45	5	35182466
Pubmed	Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis.	CHD8 SESN2	1.94e-04	16	45	2	36127134
Pubmed	Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.	KANK4 KANK3	1.94e-04	16	45	2	33253712
Pubmed	Mucocutaneous inflammation in the Ikaros Family Zinc Finger 1-keratin 5-specific transgenic mice.	CHD8 SESN2	1.94e-04	16	45	2	28914974
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ANKRD17 PLEKHA2 CHD8 SALL2 ANKHD1	2.01e-04	418	45	5	34709266
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	ANKRD17 SNRNP70 TCOF1 CTR9 DHX37 PLCH2 PPM1G	2.33e-04	971	45	7	33306668
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	ANKRD17 AP3B1 ANKHD1 TCOF1 DNAJC3 CTR9 PPM1G	2.37e-04	974	45	7	28675297
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ANKRD17 CHD8 SNRNP70 TCOF1 CTR9	2.55e-04	440	45	5	34244565
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	EPHB6 RFTN1 SNRNP70 TCOF1 CTR9 DHX37 PPM1G	2.60e-04	989	45	7	36424410
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	ANKRD17 AP3B1 ANKHD1 PPM1G	2.72e-04	242	45	4	34011540
Pubmed	Transcriptional regulatory network of SOX4 during myoblast differentiation.	CTR9 RP1L1	2.76e-04	19	45	2	25969425
Pubmed	hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.	BRME1 SNRNP70	2.76e-04	19	45	2	35739118
Pubmed	Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.	CT47B1 CT47A1	3.06e-04	20	45	2	16382448
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	SNRNP70 AP3B1 TCOF1 DHX37 PPM1G	3.42e-04	469	45	5	37314180
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	AP3B1 ANKHD1 PPM1G	3.56e-04	106	45	3	31024071
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	KANK4 CHD8 DNAJC3 TUB PPM1G	3.62e-04	475	45	5	31040226
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TMEFF1 ANKRD17 MFAP3 AP3B1 ANKHD1 TUB CTR9	4.52e-04	1084	45	7	11544199
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	SALL2 ZNF579 AP3B1 DNAJC3 CTR9	4.70e-04	503	45	5	36217030
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CHD8 ZNF579 ANKHD1 FAM83F PLEKHM2 EML3 KANK3	5.07e-04	1105	45	7	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ANKRD17 CHD8 SALL2 ZNF579 ANKHD1 TCOF1 RSF1	5.37e-04	1116	45	7	31753913
Pubmed	Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions.	TCOF1 SLC25A23	6.50e-04	29	45	2	24952082
Pubmed	Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis.	COL22A1 IBSP	8.43e-04	33	45	2	32640236
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	DCLRE1B UBQLN3 RSF1	1.11e-03	157	45	3	30686591
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	CHD8 SALL2 ANKHD1 CTR9	1.17e-03	357	45	4	37059091
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	SNRNP70 ANKHD1 TCOF1 PPM1G	1.25e-03	364	45	4	24778252
Interaction	CT45A5 interactions	ANKRD17 CHD8 AP3B1 ANKHD1 PPM1G	7.36e-07	78	44	5	int:CT45A5
Interaction	PYHIN1 interactions	TMEFF1 ANKRD17 SNRNP70 TCOF1 CTR9 PPM1G RSF1	1.15e-05	358	44	7	int:PYHIN1
Interaction	BNIP5 interactions	ANKRD17 ANKHD1 TCOF1	3.78e-05	30	44	3	int:BNIP5
Interaction	TCEANC2 interactions	ANKRD17 CTR9 PPM1G	5.54e-05	34	44	3	int:TCEANC2
Cytoband	Xq24	CT47B1 CT47A1	1.82e-03	64	45	2	Xq24
Cytoband	Ensembl 112 genes in cytogenetic band chrXq24	CT47B1 CT47A1	2.90e-03	81	45	2	chrXq24
GeneFamily	Ankyrin repeat domain containing\|KN motif and ankyrin repeat domain containing	KANK4 KANK3	1.39e-05	4	28	2	623
GeneFamily	Ankyrin repeat domain containing	KANK4 ANKRD17 ANKHD1 KANK3	4.98e-04	242	28	4	403
Computational	Neighborhood of IKBKG	AP3B1 TCOF1 TUB EML3	3.53e-04	137	27	4	MORF_IKBKG
Computational	Neighborhood of PTPN9	TCOF1 TUB EML3	4.62e-04	61	27	3	MORF_PTPN9
Disease	level of Sphingomyelin (d38:2) in blood serum	ANKRD17 KANK3	3.49e-04	19	43	2	OBA_2045179
Disease	arginine measurement	FOXQ1 FAM83F	5.15e-04	23	43	2	EFO_0020990
Disease	methionine measurement	PCDH15 ANKHD1	6.59e-04	26	43	2	EFO_0009771
Disease	C-C motif chemokine 7 measurement	SALL2 RP1L1	8.21e-04	29	43	2	EFO_0008054
Disease	hearing threshold measurement, hearing measurement	AP3B1 UBQLN3	3.59e-03	61	43	2	EFO_0007616, EFO_0007618
Disease	sphingomyelin measurement	KANK4 KANK3 PPM1G	7.73e-03	278	43	3	EFO_0010118

Protein segments in the cluster

Peptide	Gene	Start	Entry
QDGGGGDVGNSSASE	CHD8	51	Q9HCK8
EAAGAGNQEGGDSGP	CT47B1	26	P0C2W7
GGGGGTSSNNSEEEE	ANKRD17	106	O75179
GDDDGGPEATGNQSA	DCLRE1B	461	Q9H816
GEDPLDAESQQGGGG	DNAJC3	461	Q13217
SGSESGEQGESGEEG	AP3B1	696	O00203
GSGGEEAQGEVPSAG	PAGR1	61	Q9BTK6
SGEGDGGELSPQGVS	RFTN1	241	Q14699
EAAGAGNQEGGDSGP	CT47A1	26	Q5JQC4
GNQEGGDSGPDSSDV	CT47A1	31	Q5JQC4
PGGDSDDGSLNEQGQ	MFAP3	296	P55082
SGDNGATDIDDGPNG	PCDH15	171	Q96QU1
TGETTGESGEAGQDG	BRME1	391	Q0VDD7
EGSGQGSGNESEPEG	CTR9	1141	Q6PD62
PQGSQGERGADGEVG	COL22A1	1166	Q8NFW1
SQTATPGEGECGDNG	KANK3	801	Q6NY19
IEEAGTEQEGGPQGG	KANK4	501	Q5T7N3
GSGEERGGQGSDSEQ	KLHDC7A	121	Q5VTJ3
GASEEPSGTQSEGGG	EML3	111	Q32P44
LGDGGQDGGEQPDAS	DHX37	571	Q8IY37
SNGTSGGQEAGAPEE	RSF1	1406	Q96T23
PEGGGAAQENGSEQS	SALL2	726	Q9Y467
GARDTQGDGEQSAGG	FOXQ1	56	Q9C009
QGDGEQSAGGGPGAE	FOXQ1	61	Q9C009
SPEAAGQEEEGGGGE	PLEKHM2	496	Q8IWE5
GQEEEGGGGEGQTPR	PLEKHM2	501	Q8IWE5
GGNGSNPVAGLETDD	FAM174A	81	Q8TBP5
GLNGEENCSETDGPG	NRK	1076	Q7Z2Y5
GGGQDNGLEGLGNDS	SNRNP70	396	P08621
SQNGGDGQEGSEPGS	PLEKHA2	161	Q9HB19
GGVGDSGPGEEQRES	SESN2	21	P58004
NEEEGSGGGGSEEDP	RNF19B	621	Q6ZMZ0
DSSSGSEEDGEGPQG	TCOF1	1151	Q13428
AEPEEDGVGGQAGGS	EPHB6	266	O15197
GTGEEPGSQGLNGEA	PPM1G	176	O15355
AENGNGSSGGDNGEE	IBSP	186	P21815
GGGDEDENEAVGQPG	SKIV2L	221	Q15477
AGGNPEGQEEGASGG	FAM83F	351	Q8NEG4
EPRGGGAGGNSDSDN	ANKHD1	1581	Q8IWZ3
AEEGPGLQGGESGAN	ZXDB	121	P98169
QGPGVDEGEDGEGSQ	RP1L1	1736	Q8IWN7
GGDQDPGQSDGAEGI	RP1L1	1821	Q8IWN7
EGPQQSAEGSASGGG	SOGA3	316	Q5TF21
VEEGDEGQDSPGGQS	PLCH2	596	O75038
DGQGRGGGSSQAETE	USP20	296	Q9Y2K6
QQGISSEGDADPDGG	SLC25A23	51	Q9BV35
SKTGGECGNGPDDQG	XAGE3	76	Q8WTP9
DNGSGSGEGEEEGSG	TMEFF1	146	Q8IYR6
SEGGEGQNGGDAAPA	ZNF579	361	Q8NAF0
GETAAGGGERPSGQD	TUB	166	P50607
PTENSTGQGGDQDGA	UBQLN3	416	Q9H347