Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessmaintenance of postsynaptic density structure

DGKZ PRICKLE1

4.65e-059242GO:0099562
GeneOntologyBiologicalProcessrRNA processing

NOLC1 DDX56 POP4 NOP56

1.34e-04230244GO:0006364
GeneOntologyBiologicalProcessmaintenance of postsynaptic specialization structure

DGKZ PRICKLE1

1.75e-0417242GO:0098880
GeneOntologyCellularComponentsno(s)RNA-containing ribonucleoprotein complex

NOLC1 POP4 NOP56

6.45e-0632243GO:0005732
GeneOntologyCellularComponentbox C/D RNP complex

NOLC1 NOP56

2.64e-057242GO:0170049
GeneOntologyCellularComponentbox C/D methylation guide snoRNP complex

NOLC1 NOP56

2.64e-057242GO:0031428
DomainBAH

BAHCC1 ASH1L

9.39e-0511252SM00439
DomainBAH

BAHCC1 ASH1L

9.39e-0511252PF01426
DomainBAH_dom

BAHCC1 ASH1L

9.39e-0511252IPR001025
DomainBAH

BAHCC1 ASH1L

9.39e-0511252PS51038
DomainBTB-kelch_protein

KLHL36 KLHL40

1.50e-0343252IPR017096
DomainKelch-typ_b-propeller

KLHL36 KLHL40

2.45e-0355252IPR015915
DomainKelch

KLHL36 KLHL40

2.72e-0358252SM00612
DomainGal_Oxase/kelch_b-propeller

KLHL36 KLHL40

2.81e-0359252IPR011043
DomainBACK

KLHL36 KLHL40

2.90e-0360252SM00875
DomainBACK

KLHL36 KLHL40

3.00e-0361252PF07707
DomainBACK

KLHL36 KLHL40

3.00e-0361252IPR011705
DomainKelch_1

KLHL36 KLHL40

3.93e-0370252PF01344
DomainKelch_1

KLHL36 KLHL40

3.93e-0370252IPR006652
DomainBTB

KLHL36 KLHL40

1.32e-02131252PF00651
DomainPDZ

DLG5 PARD3

1.52e-02141252PF00595
DomainPDZ

DLG5 PARD3

1.66e-02148252SM00228
Domain-

DLG5 PARD3

1.70e-021502522.30.42.10
DomainPDZ

DLG5 PARD3

1.72e-02151252PS50106
DomainPDZ

DLG5 PARD3

1.75e-02152252IPR001478
DomainBTB

KLHL36 KLHL40

1.92e-02160252PS50097
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

DGKZ DDX56 DLG5 RBM8A POP4 PARD3 VIRMA PBXIP1

6.49e-06149725831527615
Pubmed

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.

NOLC1 PARD3 ARHGEF16 VIRMA

9.98e-0619025415161933
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

CENPU NOLC1 DDX56 POP4 NOP56

2.14e-0548325536912080
Pubmed

Cell-fate determination by ubiquitin-dependent regulation of translation.

NOLC1 NOP56

4.49e-051425226399832
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

NOLC1 DDX56 NOP56

5.53e-0510325332744500
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

NOLC1 DDX56 DLG5 RBM8A NOP56 PBXIP1

9.53e-05108225638697112
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

NOLC1 DDX56 REV3L PARD3 BAHCC1 ASH1L

1.13e-04111625631753913
Pubmed

Regulation of planar cell polarity by Smurf ubiquitin ligases.

PARD3 PRICKLE1

1.47e-042525219379695
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

NOLC1 DDX56 RBM8A NOP56 VIRMA

1.52e-0473125529298432
Pubmed

SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

DDX56 REV3L NOP56

1.69e-0415025330154076
Pubmed

Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis.

DLG5 PARD3

1.72e-042725223466739
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

RALGDS VIRMA ASH1L

1.79e-0415325310718198
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

CENPU NOLC1 DDX56 NOP56 VIRMA

1.81e-0475925535915203
Pubmed

Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.

NOP56 VIRMA PBXIP1

1.89e-0415625329961565
Pubmed

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.

DDX56 RBM8A POP4 ZNHIT1

2.11e-0441725436537216
Pubmed

Nucleolar proteome dynamics.

DDX56 RBM8A POP4 NOP56

2.15e-0441925415635413
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

NOLC1 DDX56 DLG5 RBM8A NOP56 VIRMA

2.16e-04125725636526897
Pubmed

Distinct nuclear and cytoplasmic assemblies and interactomes of the mammalian CTLH E3 ligase complex.

DDX56 RBM8A NOP56

2.31e-0416725335833506
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

NOLC1 DLG5 PARD3 ARHGEF16 VIRMA

3.23e-0486125536931259
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

DDX56 DLG5 RBM8A NOP56 PARD3 VIRMA

3.45e-04137125636244648
Pubmed

Update on the Kelch-like (KLHL) gene family.

KLHL36 KLHL40

4.00e-044125223676014
Pubmed

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.

FRAS1 NOP56

4.61e-044425227505670
Pubmed

Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.

CENPU VIRMA

5.26e-044725215009096
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

NOLC1 DLG5 FRAS1 NOP56 PARD3 PBXIP1

5.31e-04148725633957083
Pubmed

Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae.

AP4E1 CYP7B1

5.71e-044925231609468
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

DLG5 NOP56 PARD3 ARHGEF16

6.65e-0456525425468996
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

DDX56 DLG5 VIRMA

6.83e-0424225334011540
InteractionBRPF3 interactions

DDX56 PARD3 VIRMA BAHCC1 ASH1L

1.66e-06166255int:BRPF3
InteractionFGFBP1 interactions

CENPU DDX56 NOP56 VIRMA ASH1L

1.40e-05257255int:FGFBP1
InteractionRPL18A interactions

CENPU NOLC1 DDX56 RBM8A POP4 NOP56

1.43e-05447256int:RPL18A
InteractionRPL10 interactions

CENPU DDX56 FRAS1 RBM8A POP4 NOP56 VIRMA

1.68e-05702257int:RPL10
InteractionPOP1 interactions

DDX56 RBM8A POP4 NOP56 VIRMA

2.01e-05277255int:POP1
InteractionZNF81 interactions

VIRMA KLHL40

2.21e-056252int:ZNF81
InteractionRHOBTB2 interactions

DDX56 DLG5 RBM8A VIRMA

4.79e-05165254int:RHOBTB2
InteractionRMRP interactions

POP4 VIRMA

5.29e-059252int:RMRP
InteractionARHGAP42 interactions

PRICKLE1 VIRMA DENND2C

5.51e-0560253int:ARHGAP42
InteractionUSP36 interactions

CENPU NOLC1 DDX56 POP4 NOP56 VIRMA

7.35e-05599256int:USP36
InteractionWDR36 interactions

NOLC1 DGKZ DDX56 NOP56

1.18e-04208254int:WDR36
InteractionPARD6A interactions

DGKZ PARD3 ASH1L

1.21e-0478253int:PARD6A
InteractionPDCD11 interactions

DGKZ DDX56 POP4 NOP56 VIRMA

1.22e-04405255int:PDCD11
InteractionNOP2 interactions

NOLC1 DDX56 RBM8A NOP56 ASH1L

1.38e-04416255int:NOP2
InteractionUTRN interactions

RBM8A PARD3 ARHGEF16 VIRMA

1.38e-04217254int:UTRN
InteractionZNF106 interactions

NOP56 VIRMA KLHL40

1.50e-0484253int:ZNF106
InteractionCEP104 interactions

AP4E1 DLG5 VIRMA

1.78e-0489253int:CEP104
InteractionGOLIM4 interactions

AP4E1 VIRMA PBXIP1

1.97e-0492253int:GOLIM4
GeneFamilyKelch like|BTB domain containing

KLHL36 KLHL40

5.43e-0442152617
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KLHL36 KLHL40

5.37e-03134152861
GeneFamilyPDZ domain containing

DLG5 PARD3

6.86e-031521521220
CoexpressionSUNG_METASTASIS_STROMA_DN

CENPU NOLC1 NOP56

1.84e-0554253M2904
CoexpressionGSE11057_CD4_CENT_MEM_VS_PBMC_UP

DDX56 NOP56 PBXIP1 ASH1L

3.53e-05198254M3116
CoexpressionFUNG_IL2_SIGNALING_1

NOLC1 NOP56

3.91e-0510252M14139
ToppCellfacs-Marrow-B-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPU AP4E1 RALGDS REV3L

2.13e-06166254b21e45bd43f26149b9cd6e45c19241c82d54fb2f
ToppCellfacs-Marrow-B-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPU AP4E1 RALGDS REV3L

2.13e-0616625413027ae342994db4540e64eb910df1f42b160931
ToppCellAT1-AT2_cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

CYP7B1 DLG5 FRAS1

1.17e-041712530b9912f07393aca889db72b40da08e0bc9bc1e8c
ToppCelldroplet-Marrow-nan-21m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOLC1 DDX56 NOP56

1.54e-041882537c67330c36696a7772364af67c6df4e6406fa742
ToppCelldroplet-Marrow-nan-21m-Myeloid-Cd4_positive_Macrophages|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOLC1 DDX56 NOP56

1.54e-04188253f94dc08948a823f47882aa0714b9a60de4ff85d5
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Myeloid-Cd4_positive_Macrophages|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOLC1 DDX56 NOP56

1.62e-0419125345023854f285ac465f23ea1b33c970e14992e709
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOLC1 DDX56 NOP56

1.62e-041912536890a8e4b4530987a5b044614fcd7e00716a4d66
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 PARD3 ASH1L

1.64e-04192253e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellhuman_hepatoblastoma-Tumor_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

DLG5 FRAS1 PARD3

1.67e-04193253503a979328c68b096680b71359a26f02fafdff35
ToppCellCD8+_Memory_T_cell-CV-0|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

RALGDS DGKZ PBXIP1

1.67e-04193253995781d87a919c0380750878bafe584342bb83ad
ToppCellmoderate-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CENPU REV3L NOP56

1.69e-04194253dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-intestinal_crypt_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOLC1 DDX56 NOP56

1.72e-04195253f4f53fcfcce9d4337e09f1f8582a9c813ed40c35
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

CYP7B1 FRAS1 PARD3

1.72e-04195253603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DLG5 FRAS1 ARHGEF16

1.77e-041972531e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

CYP7B1 PARD3 PRICKLE1

1.77e-04197253f1c8936986123a3151140c374fcd62d6705c530b
ToppCellControl-PLT_4|Control / Disease Group and Platelet Clusters

CENPU RALGDS DENND2C

1.80e-04198253387fd3037fd52e4d4c42de0588767e58af228b59
ToppCellCV-Severe-2|Severe / Virus stimulation, Condition and Cluster

CENPU NOLC1 NOP56

1.80e-04198253254659bb53dc2511c714295c2df1ab1fddb2f867
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CENPU FRAS1 NOP56

1.80e-04198253d5e125f0c4f41b47d567568d0838adcca7655f6d
ToppCellCV-Moderate-2|Moderate / Virus stimulation, Condition and Cluster

CENPU NOLC1 NOP56

1.82e-0419925370d6f2a328eec4cb2cecb7cd85859fba9e15c9c8
ToppCellCD8+_Memory_T_cell-CV-2|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

CENPU NOLC1 NOP56

1.82e-041992531e33d8e2e0d6a54ef6e2e13f986e19fd209275a8
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DLG5 ARHGEF16 DENND2C

1.82e-04199253c88a28a73f54dc571f2ff1e4b55073f83cbead2c
ToppCellCV-Moderate-2|CV / Virus stimulation, Condition and Cluster

CENPU NOLC1 NOP56

1.82e-041992532d98424a5247e87f98095c11fb945289092a9d75
ToppCellcritical-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CENPU REV3L NOP56

1.85e-04200253f39db4250ce220a3eb58edee3f7fc3671701d46f
DrugRapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A

NOLC1 AP4E1 DDX56 NOP56 BAHCC1

1.83e-061912555204_DN
DrugMethoxamine hydrochloride [61-16-5]; Down 200; 16.2uM; PC3; HT_HG-U133A

RALGDS NOP56 PBXIP1 BAHCC1

5.85e-051962546627_DN
DrugIodixanol [92339-11-2]; Down 200; 2.6uM; MCF7; HT_HG-U133A

RALGDS DLG5 BAHCC1 ASH1L

5.85e-051962543362_DN
DrugIoversol [87771-40-2]; Down 200; 5uM; PC3; HT_HG-U133A

CYP7B1 RALGDS ARHGEF16 KLHL36

6.08e-051982546726_DN
DrugMoricizine hydrochloride [31883-05-3]; Up 200; 8.6uM; PC3; HT_HG-U133A

NOLC1 AP4E1 RALGDS KLHL36

6.20e-051992547297_UP
DrugNorfloxacin [70458-96-7]; Up 200; 12.6uM; HL60; HG-U133A

DLG5 PARD3 PBXIP1 BAHCC1

6.20e-051992541406_UP
DrugPyrazinamide [ 98-96-4]; Down 200; 32.4uM; PC3; HT_HG-U133A

CYP7B1 ARHGEF16 BAHCC1 ASH1L

6.20e-051992546617_DN
DrugHydroquinine hydrobromide hydrate [304695-81-6]; Down 200; 9.4uM; PC3; HT_HG-U133A

RALGDS ARHGEF16 BAHCC1 ASH1L

6.20e-051992545789_DN
Diseaseretinal detachment, retinal break

DLG5 FRAS1

4.03e-0435252EFO_0005773, EFO_0010698
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

PARD3 ASH1L

7.91e-0449252DOID:0060037 (implicated_via_orthology)
DiseaseProfound Mental Retardation

AP4E1 RALGDS

6.16e-03139252C0020796
DiseaseMental deficiency

AP4E1 RALGDS

6.16e-03139252C0917816
DiseaseMental Retardation, Psychosocial

AP4E1 RALGDS

6.16e-03139252C0025363
DiseaseIntellectual Disability

AP4E1 RALGDS ASH1L

6.20e-03447253C3714756
Diseaseserum gamma-glutamyl transferase measurement

DLG5 PARD3 BAHCC1 ASH1L

6.89e-03914254EFO_0004532
Diseaseautism spectrum disorder (implicated_via_orthology)

PRICKLE1 ASH1L

7.32e-03152252DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
LGKGRKLSKVKHKAG

BAHCC1

1831

Q9P281
HKKSGRSKEKRKSKH

ASH1L

2306

Q9NR48
KKTLGRKRGHKGSFK

ARHGEF16

196

Q5VV41
KGKISHDKRKKSRSK

CENPU

211

Q71F23
HKFRRKSKVKEAKSG

AP4E1

791

Q9UPM8
KGKSFRHEKTKKKRG

NOLC1

666

Q14978
HKLKEKAKKRKGRGF

RBM8A

26

Q9Y5S9
GHRSGSKKKRKFSKE

NOP56

551

O00567
DKKKKGKGKRHQDRG

KLHL36

601

Q8N4N3
KKVRFVHSKEKLRKG

FRAS1

1176

Q86XX4
RSFKHKGKKFRPTAK

DDX56

531

Q9NY93
RKHKHKRSGSKDGKD

DLG5

1691

Q8TDM6
HEGRITTLRKKKKGK

KLHL40

261

Q2TBA0
GQRTTKSKKKKGHKG

PRICKLE1

811

Q96MT3
KRGKKKVKLHSYTGK

DENND2C

421

Q68D51
KKRTFTKGVKVKHGA

RALGDS

881

Q12967
DGKKKTTFFKRGKKL

CYP7B1

421

O75881
KKRASFKRKSSKKGP

DGKZ

261

Q13574
FGKHRKDDKIEKTGK

PARD3

1026

Q8TEW0
FTRHKRKEKKKKAKG

POP4

61

O95707
HFFGDKALKKRSGKK

PBXIP1

691

Q96AQ6
HRRKSKHKSAKKKTG

REV3L

1046

O60673
KKKKKTRGDHFKLRF

ZNHIT1

66

O43257
GRTKTTKGFKLGKHK

VIRMA

1581

Q69YN4
SHKKRNTGKKVFKCK

ZNF680

171

Q8NEM1