Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

KCNC2 KCNC4

2.02e-0417252GO:0099508
GeneOntologyMolecularFunctiondelayed rectifier potassium channel activity

KCNC2 KCNC4

5.58e-0428252GO:0005251
GeneOntologyMolecularFunctionnucleobase-containing compound kinase activity

LRGUK CLP1

1.57e-0347252GO:0019205
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNC2 KCNC4

7.18e-03102252GO:0005249
DomainK_chnl_volt-dep_Kv3

KCNC2 KCNC4

1.03e-054252IPR003974
DomainK_chnl_volt-dep_Kv

KCNC2 KCNC4

5.92e-0427252IPR003968
DomainVG_K_chnl

KCNC2 KCNC4

8.85e-0433252IPR028325
DomainBTB_2

KCNC2 KCNC4

2.27e-0353252PF02214
DomainT1-type_BTB

KCNC2 KCNC4

2.27e-0353252IPR003131
DomainChannel_four-helix_dom

KCNC2 KCNC4

2.62e-0357252IPR027359
Domain-

KCNC2 KCNC4

2.62e-03572521.20.120.350
DomainIon_trans_dom

KCNC2 KCNC4

1.01e-02114252IPR005821
DomainIon_trans

KCNC2 KCNC4

1.01e-02114252PF00520
DomainCadherin

CDH10 FREM1

1.08e-02118252IPR002126
Domain-

NLRC5 LRGUK CLP1 MYO7B

1.64e-027462543.40.50.300
Pubmed

Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1.

KCNC2 KCNC4

1.49e-0632521740329
Pubmed

Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.

KCNC2 KCNC4

2.97e-06425221912965
Pubmed

Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal.

KCNC2 KCNC4

1.60e-04262527905852
Pubmed

Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome.

KCNC2 KCNC4

2.28e-04312528034307
Pubmed

Identification of the BRD1 interaction network and its impact on mental disorder risk.

PBRM1 EIF3I

2.91e-043525227142060
Pubmed

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

KCNC2 KCNC4

3.80e-044025216382104
CytobandEnsembl 112 genes in cytogenetic band chr2q14

MYO7B ZC3H6 SLC35F5

9.89e-05165253chr2q14
GeneFamilyPotassium voltage-gated channels

KCNC2 KCNC4

7.14e-0440182274
ToppCell3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMRN2 MPZL2 CDH10

1.40e-041822533cbeaf7904a76c32137a00abb20e302d3d3c8bb8
ToppCelldroplet-Heart-HEART-1m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN2 KCNC2 FREM1

1.62e-041912534bfdf44d4402a42530d30c89d94946acdda4321b
ToppCell5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DNAJC5G MMRN2 MPZL2

1.64e-04192253eafead22bba48ac5ee568faa8946c444445c1034
ToppCellCOVID-19-kidney-CNT|COVID-19 / Disease (COVID-19 only), tissue and cell type

KCNC4 ACTR3C FREM1

1.64e-04192253760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCellfacs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN2 MPZL2 FREM1

1.64e-0419225314a816ef116aa992f86edab411f043cf7d07fe04
ToppCellfacs-Heart-LA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN2 MPZL2 FREM1

1.64e-04192253847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MPZL2 FREM1 ADCYAP1R1

1.67e-0419325396c85b250d04b5f400512097d925061c6dc2906b
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MMRN2 MPZL2 KCNC4

1.67e-041932533f8280ef849d95b2fcea5e6824b95a07febc96d0
ToppCelldroplet-Heart-HEART-1m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN2 KCNC2 FREM1

1.67e-04193253d0a5f212f8e8a13dbbe3e41df92548ef82eef70b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNC2 FREM1 ADCYAP1R1

1.69e-041942535d0b0d8e96f0e0297a4dba70a05d87081a4eb323
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNC2 FREM1 ADCYAP1R1

1.69e-041942536ac759828c41ffa974ee82842162caa959351dd1
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNC2 FREM1 ADCYAP1R1

1.74e-041962537af6c5147ac859353504d19727dbe24f63a29dd4
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MPZL2 FREM1 ADCYAP1R1

1.74e-04196253308fa54385ca34e9e590967d4553b84aad96c92f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LRGUK EIF3I TIMM21

1.74e-041962537e98380d815fbf6254289ace2af37aac6fef51e8
ToppCell368C-Endothelial_cells-Endothelial-A_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MMRN2 EIF3I MPZL2

1.80e-041982536b8baa0b76242736f6dba482cdaad019256877ea
ToppCell368C-Endothelial_cells-Endothelial-A_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MMRN2 EIF3I MPZL2

1.80e-041982538519c7bd5f6c5a97f5e43f4729b1411d3b07e4c8
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MPZL2 KCNC4 FREM1

1.80e-041982530d9d401190792fd61434f1b82548253187d805f0
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MMRN2 MPZL2 KCNC4

1.82e-041992530602e2b2aa56d106da63bd342a38bef437b4d496
ToppCell367C-Endothelial_cells-Endothelial-A_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MMRN2 EIF3I MPZL2

1.82e-0419925362936fb64b33f7ad671f9c610bed665f17d3145e
ToppCell367C-Endothelial_cells-Endothelial-A_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MMRN2 EIF3I MPZL2

1.82e-04199253f53e0e4c34e6aec81ab07593aa11e045ba04df06
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MPZL2 FREM1 ADCYAP1R1

1.82e-04199253eeb7d370d4dfacf705306c72ccc4919ddefacff1
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

MMRN2 MPZL2 MYO7B

1.85e-04200253a8b59e6fe04271fef61db911a286b5c48438bb84
ToppCell390C-Endothelial_cells-Endothelial-B_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MMRN2 MPZL2 MYO7B

1.85e-042002538a2c6c53a39fab86750526083f7254b7413b29af
ToppCell390C-Endothelial_cells-Endothelial-B_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MMRN2 MPZL2 MYO7B

1.85e-04200253c32ad15dede3f879007c0b856f2fed1f5b058103
Diseasecomplex trait

MMRN2 NLRC5 FREM1

1.52e-03271253EFO_0010578
DiseaseDNA methylation

KCNC2 CDH10 FREM1 ADCYAP1R1

2.11e-03656254GO_0006306

Protein segments in the cluster

PeptideGeneStartEntry
YFDPHFVRIFEGEGY

C4orf47

61

A7E2U8
DGAAYFYGPIFIHPE

PBRM1

1186

Q86U86
EFFFDRHPGVFAYVL

KCNC2

101

Q96PR1
FPEHGYFRAPERGVY

MMRN2

856

Q9H8L6
DVGYERFLGPEIFFH

ACTR3C

141

Q9C0K3
RYHRDAGAPVYFYEF

CES5A

421

Q6NT32
IYYRHFGGEIFEDSF

FREM1

596

Q5H8C1
RPLDGGPEQFVFYYH

MPZL2

66

O60487
RPPYFGEGDRVDYHF

LRGUK

451

Q96M69
GFDGPRVEEYVNHFF

NLRC5

366

Q86WI3
PFPHYFDACGFDEYE

ADCYAP1R1

126

P41586
GIYLYDHFGEEGVRY

DNAJC5G

101

Q8N7S2
ENTHVDPRFYYLGPF

CDH10

351

Q9Y6N8
DGYVRIHYFDPQYFE

EIF3I

306

Q13347
FSLGFEFRPGHEYYY

EFNA2

136

O43921
IPDHEFFTAYGPDYV

HDAC8

331

Q9BY41
LEFVEDVFHGPYGNF

DIPK1A

276

Q5T7M9
NGYGFFYHIRDDRFV

CROT

561

Q9UKG9
PGFFLLHYTGFEDFE

SLC35F5

376

Q8WV83
FRDHFFDRGYYEVTP

NARS1

256

O43776
IREYFYGFRGCFYPH

CLP1

301

Q92989
GFYRDYDIPFTQRGH

ZC3H6

101

P61129
GEDGRPFHYLFYTGK

MRPS9

141

P82933
PGSGEYDFRYIFVEI

TIMM21

216

Q9BVV7
GCEFFFDRHPGVFAY

KCNC4

91

Q03721
DARFGIAHFAGEVYY

MYO7B

546

Q6PIF6