Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionkinase activity

JAK2 TYRO3 SPHK2 AXL OBSCN AK9 FGFR4 PPIP5K2 TESK1 CDK4

4.58e-057645610GO:0016301
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

JAK2 TYRO3 AXL FGFR4 TESK1

5.34e-05145565GO:0004713
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase binding

JAK2 TYRO3 AXL

2.38e-0443563GO:0043548
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

JAK2 TYRO3 SPHK2 AXL OBSCN AK9 FGFR4 PPIP5K2 TESK1 CDK4

2.48e-049385610GO:0016772
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

JAK2 TYRO3 SPHK2 AXL OBSCN FGFR4 TESK1 CDK4

7.65e-04709568GO:0016773
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

TYRO3 AXL FGFR4

8.07e-0465563GO:0004714
GeneOntologyBiologicalProcesspositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

JAK2 TYRO3 MFHAS1 AXL AKR1C4 EXTL3 PLXNB1

1.71e-06217557GO:0051897
GeneOntologyBiologicalProcessregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

JAK2 TYRO3 MFHAS1 AXL OBSCN AKR1C4 EXTL3 PLXNB1

2.73e-06334558GO:0051896
GeneOntologyBiologicalProcessphosphatidylinositol 3-kinase/protein kinase B signal transduction

JAK2 TYRO3 MFHAS1 AXL OBSCN AKR1C4 EXTL3 PLXNB1

7.32e-06382558GO:0043491
MousePhenoabnormal c-wave shape

C3 C3AR1 SLC4A5

1.08e-067453MP:0012040
DomainPROTEIN_KINASE_TYR

JAK2 TYRO3 AXL OBSCN FGFR4 TESK1

4.42e-0797566PS00109
DomainTyr_kinase_AS

JAK2 TYRO3 AXL OBSCN FGFR4 TESK1

4.42e-0797566IPR008266
Domainfn3

TYRO3 IL12RB2 TSPOAP1 AXL OBSCN ROBO3

8.80e-06162566PF00041
DomainFN3

TYRO3 IL12RB2 TSPOAP1 AXL OBSCN ROBO3

1.87e-05185566SM00060
DomainFN3

TYRO3 IL12RB2 TSPOAP1 AXL OBSCN ROBO3

2.83e-05199566PS50853
DomainFN3_dom

TYRO3 IL12RB2 TSPOAP1 AXL OBSCN ROBO3

3.72e-05209566IPR003961
DomainPkinase_Tyr

JAK2 TYRO3 AXL FGFR4 TESK1

4.19e-05129565PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

JAK2 TYRO3 AXL FGFR4 TESK1

5.78e-05138565IPR001245
DomainProtein_kinase_ATP_BS

JAK2 TYRO3 AXL OBSCN FGFR4 TESK1 CDK4

1.32e-04379567IPR017441
DomainTyrKc

JAK2 TYRO3 AXL FGFR4

1.40e-0488564SM00219
DomainTyr_kinase_cat_dom

JAK2 TYRO3 AXL FGFR4

1.40e-0488564IPR020635
Domain-

TYRO3 IL12RB2 TSPOAP1 AXL OBSCN SIRPB2 FGFR4 ROBO3 PLXNB1

1.44e-046635692.60.40.10
DomainKinase-like_dom

JAK2 TYRO3 AXL OBSCN MACF1 FGFR4 TESK1 CDK4

1.99e-04542568IPR011009
DomainIg-like_fold

TYRO3 IL12RB2 TSPOAP1 AXL OBSCN SIRPB2 FGFR4 ROBO3 PLXNB1

2.31e-04706569IPR013783
DomainIg_I-set

TYRO3 AXL OBSCN FGFR4 ROBO3

2.59e-04190565IPR013098
DomainI-set

TYRO3 AXL OBSCN FGFR4 ROBO3

2.59e-04190565PF07679
DomainPROTEIN_KINASE_ATP

JAK2 TYRO3 AXL OBSCN FGFR4 TESK1 CDK4

4.24e-04459567PS00107
DomainProt_kinase_dom

JAK2 TYRO3 AXL OBSCN FGFR4 TESK1 CDK4

6.18e-04489567IPR000719
DomainPROTEIN_KINASE_DOM

JAK2 TYRO3 AXL OBSCN FGFR4 TESK1 CDK4

6.48e-04493567PS50011
DomainIGc2

TYRO3 OBSCN SIRPB2 FGFR4 ROBO3

6.85e-04235565SM00408
DomainIg_sub2

TYRO3 OBSCN SIRPB2 FGFR4 ROBO3

6.85e-04235565IPR003598
DomainIG

TYRO3 AXL OBSCN SIRPB2 FGFR4 ROBO3

1.59e-03421566SM00409
DomainIg_sub

TYRO3 AXL OBSCN SIRPB2 FGFR4 ROBO3

1.59e-03421566IPR003599
DomainPLAT

DENND5B PKDREJ

1.79e-0321562PS50095
Domain-

DENND5B PKDREJ

1.79e-03215622.60.60.20
DomainPLAT

DENND5B PKDREJ

1.79e-0321562PF01477
DomainPLAT/LH2_dom

DENND5B PKDREJ

1.79e-0321562IPR001024
Domainig

TYRO3 AXL OBSCN FGFR4

2.52e-03190564PF00047
DomainImmunoglobulin

TYRO3 AXL OBSCN FGFR4

2.52e-03190564IPR013151
DomainIG_LIKE

TYRO3 AXL OBSCN SIRPB2 FGFR4 ROBO3

3.42e-03491566PS50835
DomainIg-like_dom

TYRO3 AXL OBSCN SIRPB2 FGFR4 ROBO3

3.85e-03503566IPR007110
Pubmed

An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain.

JAK2 FGFR4 CDK4

8.61e-07125631281307
Pubmed

Microglia aggravate white matter injury via C3/C3aR pathway after experimental subarachnoid hemorrhage.

C3 C3AR1

2.55e-06256238866102
Pubmed

Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice.

C3 C3AR1

2.55e-06256234403734
Pubmed

C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts.

C3 C3AR1

2.55e-06256231931851
Pubmed

Endothelial progenitor cell transplantation alleviated ischemic brain injury via inhibiting C3/C3aR pathway in mice.

C3 C3AR1

2.55e-06256231865842
Pubmed

Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation.

C3 C3AR1

2.55e-06256218812470
Pubmed

Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.

C3 C3AR1

2.55e-06256228283064
Pubmed

Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in Axl/Tyro3 null mice.

TYRO3 AXL

2.55e-06256221539887
Pubmed

Defective engraftment of C3aR-/- hematopoietic stem progenitor cells shows a novel role of the C3a-C3aR axis in bone marrow homing.

C3 C3AR1

2.55e-06256219357704
Pubmed

Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus.

JAK2 IL12RB2

2.55e-06256210198225
Pubmed

Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression.

C3 C3AR1

2.55e-06256229118090
Pubmed

C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury.

C3 C3AR1

2.55e-06256215240660
Pubmed

Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models.

C3 C3AR1

2.55e-06256211342658
Pubmed

Downregulation of complement C3 and C3aR expression in subcutaneous adipose tissue in obese women.

C3 C3AR1

2.55e-06256224743347
Pubmed

Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic-ischemic brain injury.

C3 C3AR1

2.55e-06256223737250
Pubmed

Negative regulation of pulmonary Th17 responses by C3a anaphylatoxin during allergic inflammation in mice.

C3 C3AR1

2.55e-06256223285141
Pubmed

Upregulated flotillins and sphingosine kinase 2 derail AXL vesicular traffic to promote epithelial-mesenchymal transition.

SPHK2 AXL

2.55e-06256235394045
Pubmed

Deletion of the complement anaphylatoxin C3a receptor attenuates, whereas ectopic expression of C3a in the brain exacerbates, experimental autoimmune encephalomyelitis.

C3 C3AR1

2.55e-06256215383607
Pubmed

Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow.

C3 C3AR1

2.55e-06256214604969
Pubmed

Complement component 3C3 and C3a receptor are required in chitin-dependent allergic sensitization to Aspergillus fumigatus but dispensable in chitin-induced innate allergic inflammation.

C3 C3AR1

2.55e-06256223549917
Pubmed

Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity.

C3 C3AR1

2.55e-06256227697835
Pubmed

The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression.

C3 C3AR1

2.55e-0625629164946
Pubmed

The complement C3-C3aR pathway mediates microglia-astrocyte interaction following status epilepticus.

C3 C3AR1

2.55e-06256233314324
Pubmed

The Complement C3a-C3a Receptor Axis Regulates Epithelial-to-Mesenchymal Transition by Activating the ERK Pathway in Pancreatic Ductal Adenocarcinoma.

C3 C3AR1

2.55e-06256235220210
Pubmed

Identification of novel protein kinases expressed in the myocardium of the developing mouse heart.

JAK2 TYRO3 FGFR4

4.42e-06205637893599
Pubmed

Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis.

C3 C3AR1

7.63e-06356220625009
Pubmed

Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis.

C3 C3AR1

7.63e-06356232717081
Pubmed

brt, a mouse gene encoding a novel receptor-type protein-tyrosine kinase, is preferentially expressed in the brain.

TYRO3 AXL

7.63e-0635628108111
Pubmed

Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.

TYRO3 AXL

7.63e-06356223071254
Pubmed

TAM receptors are dispensable in the phagocytosis and killing of bacteria.

TYRO3 AXL

7.63e-06356219625016
Pubmed

TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus.

TYRO3 AXL

7.63e-06356220637106
Pubmed

High incidence of distal vaginal atresia in mice lacking Tyro3 RTK subfamily.

TYRO3 AXL

7.63e-06356218393392
Pubmed

Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis.

TYRO3 AXL

7.63e-06356237537628
Pubmed

Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain.

C3 C3AR1

7.63e-06356226822321
Pubmed

Association between peripheral blood WBCs C3aR mRNA level and plasma C3a, C3aR, IL-1β concentrations and acute exacerbation of chronic obstructive pulmonary disease.

C3 C3AR1

7.63e-06356234923262
Pubmed

The role of Tyro 3 subfamily receptors in the regulation of hemostasis and megakaryocytopoiesis.

TYRO3 AXL

7.63e-06356217488688
Pubmed

Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death.

TYRO3 AXL

7.63e-06356223840307
Pubmed

Transplantation studies in C3-deficient animals reveal a novel role of the third complement component (C3) in engraftment of bone marrow cells.

C3 C3AR1

7.63e-06356215284858
Pubmed

Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis.

TYRO3 AXL

7.63e-06356230335822
Pubmed

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages.

C3 C3AR1

7.63e-06356236174103
Pubmed

Complement C3a-induced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness via neutrophilic inflammation in mice.

C3 C3AR1

7.63e-06356222539791
Pubmed

Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation.

TYRO3 AXL

7.63e-06356225074926
Pubmed

Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice.

TYRO3 AXL

7.63e-06356219602523
Pubmed

Autocrine role for Gas6 with Tyro3 and Axl in leiomyosarcomas.

TYRO3 AXL

7.63e-06356223354874
Pubmed

The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases.

TYRO3 AXL

7.63e-06356215964779
Pubmed

TAM and TIM receptors mRNA expression in Zika virus infected placentas.

TYRO3 AXL

7.63e-06356233011564
Pubmed

Tyro-3 family receptors are essential regulators of mammalian spermatogenesis.

TYRO3 AXL

7.63e-06356210227296
Pubmed

Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice.

C3 C3AR1

7.63e-06356219684087
Pubmed

Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells.

TYRO3 AXL

7.63e-06356217442946
Pubmed

TAM receptors and their ligand-mediated activation: Role in atherosclerosis.

TYRO3 AXL

7.63e-06356233234243
Pubmed

Post-translational modifications of the ligands: Requirement for TAM receptor activation.

TYRO3 AXL

7.63e-06356233234244
Pubmed

Recent advancements in role of TAM receptors on efferocytosis, viral infection, autoimmunity, and tissue repair.

TYRO3 AXL

7.63e-06356233234241
Pubmed

Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases.

TYRO3 AXL

7.63e-06356216751775
Pubmed

Immunological role of TAM receptors in the cancer microenvironment.

TYRO3 AXL

7.63e-06356233234245
Pubmed

TAM Receptors Are Not Required for Zika Virus Infection in Mice.

TYRO3 AXL

7.63e-06356228423319
Pubmed

TAM receptors in apoptotic cell clearance, autoimmunity, and cancer.

TYRO3 AXL

7.63e-06356223662598
Pubmed

The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity.

TYRO3 AXL

7.63e-06356226523970
Pubmed

TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer.

TYRO3 AXL

7.63e-06356218620092
Pubmed

Complement 3a induces the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms during the development and progression of Alzheimer's disease.

C3 C3AR1

7.63e-06356239218048
Pubmed

TAM receptors support neural stem cell survival, proliferation and neuronal differentiation.

TYRO3 AXL

7.63e-06356225514676
Pubmed

Complement system is activated in stenotic aortic valves.

C3 C3AR1

7.63e-06356217498719
Pubmed

Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma.

TYRO3 AXL

7.63e-06356229024938
Pubmed

New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis.

TYRO3 AXL

7.63e-06356232051695
Pubmed

TAM receptor knockout mice are susceptible to retinal autoimmune induction.

TYRO3 AXL

7.63e-06356221467176
Pubmed

Development of a spontaneous liver disease resembling autoimmune hepatitis in mice lacking tyro3, axl and mer receptor tyrosine kinases.

TYRO3 AXL

7.63e-06356223799121
Pubmed

The association of Tyro3/Axl/Mer signaling with inflammatory response, disease activity in patients with primary Sjögren's syndrome.

TYRO3 AXL

7.63e-06356225881761
Pubmed

Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses.

TYRO3 AXL

7.63e-06356215733062
Pubmed

H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3.

JAK2 IL12RB2

7.63e-06356228947543
Pubmed

Transcriptome analysis of neural progenitor cells by a genetic dual reporter strategy.

TYRO3 AXL

7.63e-06356221805534
Pubmed

Antigen-presenting cell-derived complement modulates graft-versus-host disease.

C3 C3AR1

7.63e-06356222585573
Pubmed

Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1.

C3 C3AR1

7.63e-06356212511407
Pubmed

Activation of TYRO3/AXL tyrosine kinase receptors in thyroid cancer.

TYRO3 AXL

7.63e-06356221343401
Pubmed

Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation.

TYRO3 AXL

7.63e-06356230541554
Pubmed

TYRO3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer.

TYRO3 AXL

7.63e-06356230765874
Pubmed

Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation.

TYRO3 AXL

7.63e-06356221192804
Pubmed

Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis.

C3 C3AR1

7.63e-06356216034139
Pubmed

TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti-PD-1 Therapy in Melanoma.

TYRO3 AXL

7.63e-06356231451482
Pubmed

Increased soluble phagocytic receptors sMer, sTyro3 and sAxl and reduced phagocytosis in juvenile-onset systemic lupus erythematosus.

TYRO3 AXL

7.63e-06356225878564
Pubmed

Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family.

TYRO3 AXL

7.63e-06356211452127
Pubmed

Increased hematopoietic cells in the mertk-/- mouse peritoneal cavity: a result of augmented migration.

TYRO3 AXL

7.63e-06356220483720
Pubmed

Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder.

C3 C3AR1

7.63e-06356234543680
Pubmed

Deficiency of the Complement Component 3 but Not Factor B Aggravates Staphylococcus aureus Septic Arthritis in Mice.

C3 C3AR1

7.63e-06356226787717
Pubmed

Tyro3 family-mediated cell entry of Ebola and Marburg viruses.

TYRO3 AXL

7.63e-06356217005688
Pubmed

Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice.

C3 C3AR1

7.63e-06356216547268
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

JAK2 SPHK2 SZT2 MFHAS1 OBSCN NAV2 LRP3 EXTL3 TESK1 DHX30

9.50e-061105561035748872
Pubmed

The protein tyrosine kinase family of the human genome.

JAK2 TYRO3 AXL FGFR4

1.01e-058356411114734
Pubmed

Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer.

AXL ROBO3

1.52e-05456235993361
Pubmed

C3a, C5a renal expression and their receptors are correlated to severity of IgA nephropathy.

C3 C3AR1

1.52e-05456224327134
Pubmed

Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl.

TYRO3 AXL

1.52e-0545628621659
Pubmed

Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.

TYRO3 AXL

1.52e-05456215650770
Pubmed

Role of the Gas6/TAM System as a Disease Marker and Potential Drug Target.

TYRO3 AXL

1.52e-05456233532004
Pubmed

Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion.

C3 C3AR1

1.52e-05456232568214
Pubmed

The Gas6/TAM System and Multiple Sclerosis.

TYRO3 AXL

1.52e-05456227801848
Pubmed

Increased sMer, but not sAxl, sTyro3, and Gas6 relate with active disease in juvenile systemic lupus erythematosus.

TYRO3 AXL

1.52e-05456231655933
Pubmed

Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3.

C3 C3AR1

1.52e-05456234707103
Pubmed

Heterogeneous nuclear ribonucleoprotein P2 is an autoantibody target in mice deficient for Mer, Axl, and Tyro3 receptor tyrosine kinases.

TYRO3 AXL

1.52e-05456216365397
Pubmed

Diversification of TAM receptor tyrosine kinase function.

TYRO3 AXL

1.52e-05456225194421
Pubmed

Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells.

TYRO3 AXL

1.52e-05456218159085
Pubmed

Molecular cloning and characterization of the human anaphylatoxin C3a receptor.

C3 C3AR1

1.52e-0545628702752
Pubmed

Sertoli cell-initiated testicular innate immune response through toll-like receptor-3 activation is negatively regulated by Tyro3, Axl, and mer receptors.

TYRO3 AXL

1.52e-05456220363878
GeneFamilyFibronectin type III domain containing

TYRO3 IL12RB2 TSPOAP1 AXL OBSCN ROBO3

1.12e-06160396555
GeneFamilyReceptor Tyrosine Kinases|CD molecules

TYRO3 AXL FGFR4

8.68e-0540393321
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

TYRO3 OBSCN FGFR4 ROBO3

3.91e-04161394593
GeneFamilyComplement system|Sushi domain containing

C3 C3AR1

2.73e-0336392492
ToppCellfacs-Liver-Hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAAF3 AXL GINS2 C3AR1 SLC4A5

2.24e-061685654ae9e9d93bcd6f4d5815e57fd5afa7a3398a0ec1
ToppCellThalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2-Excitatory_Neuron.Slc17a7.Tac2.Chat_(Habenular_cholinergic_cells)|Thalamus / BrainAtlas - Mouse McCarroll V32

OBSCN FGFR4 ROBO3 PKDREJ

3.50e-068256451dd9ab3ddb26d3d3395d0c1a156a12a86caf89b
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTL5 OBSCN ROBO3 PRSS36

5.02e-05161564ed93cb6c133855a5c244821e1a260aae8ab4df9a
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTL5 OBSCN ROBO3 PRSS36

5.02e-051615640089d7bb305c592392791862a3341fc92af8f3e2
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_3|343B / Donor, Lineage, Cell class and subclass (all cells)

AXL OTUD1 LRP3 C3AR1

5.14e-051625640acb8f7b51bf422d4f4f8e99bd10360163ae4eb7
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTL5 PKDREJ SLX4 PLXNB1

5.27e-05163564132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage|343B / Donor, Lineage, Cell class and subclass (all cells)

RTL5 ACOT11 C3AR1 PRSS36

5.39e-05164564057ca87847373eff7fe97dd9f4358509e66ca4c3
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

SZT2 ACOT11 OBSCN PLXNB1

5.65e-0516656432d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCelldroplet-Lung-LUNG-1m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAK2 DNAAF3 GINS2 CASQ1

5.79e-05167564e30e7ac8ea4399dc3c1d94fc6b857afc80a7a671
ToppCellfacs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAAF3 AXL C3AR1 SLC4A5

5.92e-0516856404e168fe1d6f5f9e3d3bf9d7c13e800e3594868a
ToppCellfacs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAAF3 AXL C3AR1 SLC4A5

6.06e-05169564454b92b9b67299a64278c010db033ca5b9d217a0
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AXL OTUD1 C3 C3AR1

6.06e-051695640867528101767fc65e93b3561480bf830c50368d
ToppCell356C-Myeloid-Macrophage-SPP1+_Macrophage_4|356C / Donor, Lineage, Cell class and subclass (all cells)

C3AR1 SIRPB2 PRSS36 SLX4

6.78e-0517456475b3a852140fb726025c3c987143d67944afde2d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

IL12RB2 RTL5 SIRPB2 PRSS36

7.41e-0517856424e8c62060455159235985f456af0c5023a7f3f5
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

IL12RB2 RTL5 SIRPB2 PRSS36

7.41e-051785644f1cc954d4d9b5b2b75a4cf995ba81e2ada27084
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AXL OTUD1 C3 C3AR1

8.07e-0518256416186b7a0c33caa48631962381e3ab7e5d166163
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAAF3 TSPOAP1 C3 MYCBPAP

8.42e-05184564264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

MFHAS1 AXL MACF1 C3

8.42e-05184564d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAAF3 TSPOAP1 C3 MYCBPAP

8.42e-05184564d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAAF3 TSPOAP1 C3 MYCBPAP

8.42e-0518456422010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCellBAL-Severe-Myeloid-Macrophage|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ACOT11 SIRPB2 ROBO3 PRSS36

8.60e-05185564ae966929fb5bbb08ffcbac76cb21941638727f55
ToppCellBAL-Severe-Myeloid-Macrophage-transitional_Macro-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ACOT11 SIRPB2 ROBO3 PRSS36

8.60e-051855643beebaa92275086b1fae5f8c0c3d54016c5ba2aa
ToppCellBAL-Severe-Myeloid-Macrophage-transitional_Macro-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ACOT11 SIRPB2 ROBO3 PRSS36

8.60e-05185564ceff11cfa679147ccfd0a0f8079e697a6bea34d9
ToppCellBAL-Severe-Myeloid-Macrophage|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ACOT11 SIRPB2 ROBO3 PRSS36

8.60e-051855649aea5ed8f9cee5ee933891203aac7adb85d68201
ToppCellBAL-Severe-Myeloid-Macrophage-transitional_Macro|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ACOT11 SIRPB2 ROBO3 PRSS36

8.60e-0518556442939b294ea3e871274d8b73124c850dc1904fd2
ToppCellSevere_COVID-19-Myeloid-transitional_Macro|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

ACOT11 SIRPB2 ROBO3 PRSS36

8.60e-05185564f7ef0d7740b4cfedc38846e802898c402dc411fd
ToppCellBAL-Severe-Myeloid-Macrophage-transitional_Macro|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ACOT11 SIRPB2 ROBO3 PRSS36

8.60e-051855647a3612520ae4f0cd61480eadba31eecce001419d
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AXL OTUD1 C3 C3AR1

9.15e-051885643f47395db7e6159fc95810545bad4b6e028464c5
ToppCellMS-mono3|MS / Condition, Cell_class and T cell subcluster

AXL OTUD1 C3 C3AR1

9.15e-05188564a50a766c2f02e776c8e5c6e0833ec241c61831c4
ToppCellMS-mono3-|MS / Condition, Cell_class and T cell subcluster

AXL OTUD1 C3 C3AR1

9.15e-05188564e8c1c2941ca4919e0097a65b692b7af8018e8886
ToppCellRA-14._Fibroblast_III|RA / Chamber and Cluster_Paper

MFHAS1 AXL NAV2 C3

9.34e-0518956446e9a58aacd79db5a02898a8c7244e1884adcfd1
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast|PND07-28-samps / Age Group, Lineage, Cell class and subclass

NAV2 MACF1 FGFR4 PPM1K

9.34e-05189564dc5164591dea45b420798b94dda211be03daa70c
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3|PND07-28-samps / Age Group, Lineage, Cell class and subclass

LRATD1 NAV2 MACF1 PPM1K

9.53e-051905641196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

NAV2 MACF1 FGFR4 PPM1K

9.73e-05191564e7c605b56934d1383237c1f946dbccef25d91368
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MUC15 NAV2 PPM1K PLXNB1

9.92e-051925648769b67d1cad1be65da3938f916e5bf88f88f6b8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AXL C3 C3AR1 SIRPB2

9.92e-051925645ea1a8119012eb8bc3100b739a0430377a8ac534
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NAV2 MACF1 FGFR4 PPM1K

9.92e-051925640afb9dbe468e0be442c326e11c5fc0f699b32f23
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1|TCGA-Endometrium / Sample_Type by Project: Shred V9

LRATD1 NAV2 GINS2 EXTL3

1.01e-04193564c2673d86f7d7b849788036032a93a6d136a70040
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AXL OTUD1 C3 C3AR1

1.01e-0419356426a55e98005163122d277480d1d44dd6910ab42f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AXL OTUD1 C3 C3AR1

1.05e-04195564b6bf75669f267ecdc96818c7022db852e37a9fe1
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast|PND01-03-samps / Age Group, Lineage, Cell class and subclass

NAV2 MACF1 FGFR4 PPM1K

1.07e-0419656454f4cf778f95a9ff662e5c7520916a25e605bf95
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

C3 C3AR1 SIRPB2 SEC23A

1.12e-04198564af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellnormal_Lung-Fibroblasts-COL13A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

NAV2 MACF1 FGFR4 PPM1K

1.12e-04198564e0e47cf65774191981840b22905b2094b95abe0f
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

C3 C3AR1 SIRPB2 SEC23A

1.12e-04198564ad39cce004867f083f8da1954e0cf5a263815184
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

C3 C3AR1 SIRPB2 SEC23A

1.12e-0419856462cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AXL OTUD1 C3 C3AR1

1.14e-041995645a291fa161c37ec31e9c43d9b3075c3e06333261
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AXL OTUD1 C3 C3AR1

1.14e-04199564e7faf7d0cb43cf93149c446e5f718f84fa85477c
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Slco3a1_(Slco3a1)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CASQ1 FGFR4 CREB3L4

1.16e-0475563574ed1836f6bf5fa38a53af0a05fa4437f68f36b
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Slco3a1_(Slco3a1)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CASQ1 FGFR4 CREB3L4

1.16e-047556345f7861bfeb1c6371b73cf2ea527801342e534bc
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AXL C3 C3AR1 TESK1

1.16e-04200564838f87cc55652512d240c5952ee4b3870fb2399f
ToppCellLA-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

AVPR2 AKR1C4 PLXNB1

1.86e-04885637232b13a9788f89600411222c0d93bdc3788816f
Diseaseclonal hematopoiesis

JAK2 DNAAF3

1.47e-0410542EFO_0010819
Diseasedystonia (is_implicated_in)

TSPOAP1 NUP54

2.95e-0414542DOID:543 (is_implicated_in)
Diseasefertility measurement

LRATD1 NAV2

2.95e-0414542EFO_0006923
Diseaseglomerulonephritis (implicated_via_orthology)

AXL C3

4.39e-0417542DOID:2921 (implicated_via_orthology)
Diseaseparental emotion expression measurmement, conduct disorder

MFHAS1 PPM1K

9.60e-0425542EFO_0004216, EFO_0008342
Diseasehepatocellular carcinoma (biomarker_via_orthology)

JAK2 C3 CDK4

1.03e-03108543DOID:684 (biomarker_via_orthology)
Diseasedigestive system infectious disorder

TYRO3 MFHAS1

1.04e-0326542MONDO_0043424
Diseasemyeloperoxidase measurement

TSPOAP1 SIRPB2

1.04e-0326542EFO_0005243
DiseaseMiddle Cerebral Artery Embolus

SPHK2 C3

1.78e-0334542C0751845
DiseaseEmbolic Infarction, Middle Cerebral Artery

SPHK2 C3

1.78e-0334542C0751847
DiseaseLeft Middle Cerebral Artery Infarction

SPHK2 C3

1.78e-0334542C0751846
DiseaseRight Middle Cerebral Artery Infarction

SPHK2 C3

1.78e-0334542C0751849
DiseaseThrombotic Infarction, Middle Cerebral Artery

SPHK2 C3

1.78e-0334542C0751848
DiseaseMiddle Cerebral Artery Occlusion

SPHK2 C3

1.78e-0334542C0740391
DiseaseInfarction, Middle Cerebral Artery

SPHK2 C3

1.78e-0334542C0740392
DiseaseMiddle Cerebral Artery Thrombosis

SPHK2 C3

1.78e-0334542C0740376
DiseaseMiddle Cerebral Artery Syndrome

SPHK2 C3

1.78e-0334542C0238281

Protein segments in the cluster

PeptideGeneStartEntry
ILLPPILWRDELEPC

VANGL1

131

Q8TAA9
LWVDPNSPVLLEDPV

AKR1C4

226

P17516
PPDGWELIEPTLDEL

BUD31

11

P41223
DAWPFLLPVNLKLVP

BAZ2B

2081

Q9UIF8
SLDLPLDPLWEFPRD

FGFR4

451

P22455
LGVLPLSWDIPELVN

C3

186

P01024
LDADDQPQLLPWIRP

ACOT11

326

Q8WXI4
LDPSNEALIWLDPLP

DNHD1

3556

Q96M86
WIAPELRLQSDDILP

DHX30

371

Q7L2E3
TDLLSQPWNEPPVIL

C3AR1

11

Q16581
IWDNRIDEPILLPPS

PPM1K

66

Q8N3J5
SVVLAWEPPPEQVEL

TSPOAP1

806

O95153
ILQERIPWVPPECIE

JAK2

711

O60674
WLLEELLRPDCPEPA

OTUD1

166

Q5VV17
PWNAPIADEDLLPIS

MUC15

121

Q8N387
PLVEELNVLLQEWPG

MFHAS1

961

Q9Y4C4
QLPLDRLLIDWPTPE

IL12RB2

686

Q99665
PLEATPILEWPGIQL

PLXNB1

391

O43157
EPVLEEWIPVLQRPS

MACF1

821

O94854
LDWLLLGPAAPPRQE

LRP3

101

O75074
EPGDLLELLWLQPAP

LRATD1

121

Q96KN4
DPQEPPWVEVLVEIL

MYBBP1A

641

Q9BQG0
LALPVWRPPDFEEEL

OBSCN

6006

Q5VST9
LLQNPPAGVDPIIWE

NUP54

296

Q7Z3B4
VQEADPLPLPWVLQE

PRSS36

181

Q5K4E3
PLPLPWVLQEVELRL

PRSS36

186

Q5K4E3
VPEPDRLEEQLPWLS

DNAAF3

141

Q8N9W5
IFDLIGLPPEDDWPR

CDK4

226

P11802
LPSEDLLWPDIGVPI

EXTL3

701

O43909
LSIIWIDPDDFPLLV

CASQ1

316

P31415
RLLPQWIPLLAECPA

DENND5B

1216

Q6ZUT9
WRNPLPPIDLADIED

C9orf40

156

Q8IXQ3
PDLLDAWLEPPEDIF

CREB3L4

6

Q8TEY5
LLGLSEWPEEQPLLF

OR1N2

31

Q8NGR9
WPVPIVPVLAEENLE

RTL5

56

Q5HYW3
LLELAEQPPDRPLWR

SYT3

406

Q9BQG1
QELEVLSVLPPGWQP

SZT2

56

Q5T011
EPLPPEILEVILSEW

AK9

1096

Q5TCS8
PDWTQPLDLPQLEIR

PKDREJ

271

Q9NTG1
FNPGLPVEVPLWLAI

GINS2

36

Q9Y248
QHEWPPLLQLRPEDV

NAV2

2406

Q8IVL1
TLEPPLPEDTVLWEL

PSD4

286

Q8NDX1
TDLLGELQRDPWPVP

SEC23A

241

Q15436
EPLSPIPIDHWNLER

SLX4

1431

Q8IY92
PVLPPTITDQIRLWE

GTF2H4

381

Q92759
EPDLWIIQPQELVLG

SIRPB2

156

Q5JXA9
PLPPDWVTLEGDFVL

SPHK2

526

Q9NRA0
PLPPPEEEASWALEL

ROBO3

1271

Q96MS0
PEPVDLLWLQDAVPL

AXL

166

P30530
EPDGLPLLEWNLCLE

MYCBPAP

711

Q8TBZ2
EVIVLPPGEWDPNIR

SLC4A5

396

Q9BY07
PLLIECWVEAVPPQL

TEX10

326

Q9NXF1
LEWILEQLPEPAPLT

TESK1

311

Q15569
IPWSIPLEAEDIPIV

PPIP5K2

356

O43314
IEEPFFSPLWPLLLA

VPS9D1

446

Q9Y2B5
EWEEVIPEAPLEGPL

TYRO3

341

Q06418
WDPEAPLEGAPFVLL

AVPR2

296

P30518