Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chitobiosyldiphosphodolichol beta-mannosyltransferase activity	ALG1L2 ALG1	1.62e-05	3	47	2	GO:0004578
GeneOntologyMolecularFunction	beta-1,4-mannosyltransferase activity	ALG1L2 ALG1	1.62e-05	3	47	2	GO:0019187
GeneOntologyCellularComponent	ruffle	ASAP3 GAS7 ROCK1 MEFV PACSIN2	1.07e-04	206	48	5	GO:0001726
GeneOntologyCellularComponent	PTW/PP1 phosphatase complex	PPP1CA PPP1CC	1.08e-04	7	48	2	GO:0072357
GeneOntologyCellularComponent	microtubule organizing center	ROCK1 CEP152 CCDC57 TUBD1 DNAAF4 PACSIN2 DYRK3 PPP1CC CCDC18	2.11e-04	919	48	9	GO:0005815
GeneOntologyCellularComponent	centriole	ROCK1 CEP152 CCDC57 TUBD1	6.49e-04	172	48	4	GO:0005814
GeneOntologyCellularComponent	protein phosphatase type 1 complex	PPP1CA PPP1CC	8.61e-04	19	48	2	GO:0000164
GeneOntologyCellularComponent	cell leading edge	ASAP3 GAS7 ROCK1 SLK MEFV PACSIN2	9.51e-04	500	48	6	GO:0031252
GeneOntologyCellularComponent	nuclear body	GCNA DOCK1 MAPK7 SLF2 DDX39B PACSIN2 DYRK3 PPP1CC	9.55e-04	903	48	8	GO:0016604
GeneOntologyCellularComponent	presynaptic active zone cytoplasmic component	UNC13B PPFIA3	1.27e-03	23	48	2	GO:0098831
GeneOntologyCellularComponent	pericentriolar material	CEP152 DYRK3	1.88e-03	28	48	2	GO:0000242
GeneOntologyCellularComponent	glutamatergic synapse	DOCK1 UNC13B PPFIA3 PACSIN2 SH3GL1 PPP1CA PPP1CC	2.47e-03	817	48	7	GO:0098978
GeneOntologyCellularComponent	PML body	GCNA MAPK7 SLF2	2.97e-03	125	48	3	GO:0016605
GeneOntologyCellularComponent	nuclear speck	DOCK1 DDX39B PACSIN2 DYRK3 PPP1CC	3.01e-03	431	48	5	GO:0016607
GeneOntologyCellularComponent	centriolar satellite	CCDC57 PACSIN2 CCDC18	3.17e-03	128	48	3	GO:0034451
GeneOntologyCellularComponent	presynapse	UNC13B PPFIA3 SCGN SLC24A2 SH3GL1 PPP1CA PPP1CC	3.88e-03	886	48	7	GO:0098793
Domain	PKK	STK10 SLK	5.93e-06	2	46	2	PF12474
Domain	PKK	STK10 SLK	5.93e-06	2	46	2	IPR022165
Domain	STPPase_N	PPP1CA PPP1CC	1.78e-05	3	46	2	PF16891
Domain	ALG1-like	ALG1L2 ALG1	1.78e-05	3	46	2	IPR026051
Domain	STPPase_N	PPP1CA PPP1CC	1.78e-05	3	46	2	IPR031675
Domain	Znf_C2H2-like	RLF ZC3H7A ZNF131 ZNF761 ZNF100 ZNF680 TRAFD1 ZNF658 ZNF423	1.18e-04	796	46	9	IPR015880
Domain	Glyco_trans_1	ALG1L2 ALG1	1.24e-04	7	46	2	IPR001296
Domain	Glycos_transf_1	ALG1L2 ALG1	1.24e-04	7	46	2	PF00534
Domain	Znf_C2H2	RLF ZC3H7A ZNF131 ZNF761 ZNF100 ZNF680 TRAFD1 ZNF658 ZNF423	1.29e-04	805	46	9	IPR007087
Domain	ZnF_C2H2	RLF ZC3H7A ZNF131 ZNF761 ZNF100 ZNF680 TRAFD1 ZNF658 ZNF423	1.32e-04	808	46	9	SM00355
Domain	Ser/Thr-sp_prot-phosphatase	PPP1CA PPP1CC	4.55e-04	13	46	2	IPR006186
Domain	SER_THR_PHOSPHATASE	PPP1CA PPP1CC	4.55e-04	13	46	2	PS00125
Domain	PP2Ac	PPP1CA PPP1CC	4.55e-04	13	46	2	SM00156
Domain	ZINC_FINGER_C2H2_2	RLF ZC3H7A ZNF131 ZNF761 ZNF100 ZNF680 ZNF658 ZNF423	5.45e-04	775	46	8	PS50157
Domain	ZINC_FINGER_C2H2_1	RLF ZC3H7A ZNF131 ZNF761 ZNF100 ZNF680 ZNF658 ZNF423	5.55e-04	777	46	8	PS00028
Domain	SH3_1	DOCK1 GAS7 PACSIN2 SH3GL1	7.02e-04	164	46	4	PF00018
Domain	zf-C2H2_6	ZNF761 ZNF100 ZNF680 ZNF658 ZNF423	1.01e-03	314	46	5	PF13912
Domain	-	RLF ZNF131 ZNF761 ZNF100 ZNF680 ZNF658 ZNF423	1.27e-03	679	46	7	3.30.160.60
Domain	FCH	GAS7 PACSIN2	1.33e-03	22	46	2	PF00611
Domain	FCH	GAS7 PACSIN2	1.33e-03	22	46	2	SM00055
Domain	zf-C2H2	RLF ZNF131 ZNF761 ZNF100 ZNF680 ZNF658 ZNF423	1.43e-03	693	46	7	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	RLF ZNF131 ZNF761 ZNF100 ZNF680 ZNF658 ZNF423	1.44e-03	694	46	7	IPR013087
Domain	FCH_dom	GAS7 PACSIN2	1.45e-03	23	46	2	IPR001060
Domain	tRNA-bd_arm	CEP152 PPFIA3	1.58e-03	24	46	2	IPR010978
Domain	TRAF-like	TRAFD1 TRIM37	1.58e-03	24	46	2	IPR008974
Domain	F_BAR	GAS7 PACSIN2	1.72e-03	25	46	2	IPR031160
Domain	F_BAR	GAS7 PACSIN2	1.72e-03	25	46	2	PS51741
Domain	Ser/Thr_kinase_AS	STK10 ROCK1 SLK MAPK7 DYRK3	1.79e-03	357	46	5	IPR008271
Domain	S_TKc	STK10 ROCK1 SLK MAPK7 DYRK3	1.83e-03	359	46	5	SM00220
Domain	PROTEIN_KINASE_ST	STK10 ROCK1 SLK MAPK7 DYRK3	1.90e-03	362	46	5	PS00108
Domain	SH3	DOCK1 GAS7 PACSIN2 SH3GL1	1.94e-03	216	46	4	PS50002
Domain	SH3	DOCK1 GAS7 PACSIN2 SH3GL1	1.94e-03	216	46	4	SM00326
Domain	SH3_domain	DOCK1 GAS7 PACSIN2 SH3GL1	2.08e-03	220	46	4	IPR001452
Domain	Calcineurin-like_PHP_ApaH	PPP1CA PPP1CC	2.15e-03	28	46	2	IPR004843
Domain	Metallophos	PPP1CA PPP1CC	2.15e-03	28	46	2	PF00149
Domain	Protein_kinase_ATP_BS	STK10 ROCK1 SLK MAPK7 DYRK3	2.32e-03	379	46	5	IPR017441
Domain	Pkinase	STK10 ROCK1 SLK MAPK7 DYRK3	2.37e-03	381	46	5	PF00069
Domain	-	ASAP3 SH3GL1	2.47e-03	30	46	2	1.20.1270.60
Domain	AH/BAR-dom	ASAP3 SH3GL1	2.47e-03	30	46	2	IPR027267
Domain	Metallo-depent_PP-like	PPP1CA PPP1CC	2.47e-03	30	46	2	IPR029052
Domain	-	PPP1CA PPP1CC	2.47e-03	30	46	2	3.60.21.10
Domain	PROTEIN_KINASE_ATP	STK10 ROCK1 SLK MAPK7 DYRK3	5.25e-03	459	46	5	PS00107
Domain	Prot_kinase_dom	STK10 ROCK1 SLK MAPK7 DYRK3	6.83e-03	489	46	5	IPR000719
Domain	PROTEIN_KINASE_DOM	STK10 ROCK1 SLK MAPK7 DYRK3	7.06e-03	493	46	5	PS50011
Domain	Kinase-like_dom	STK10 ROCK1 SLK MAPK7 DYRK3	1.04e-02	542	46	5	IPR011009
Domain	ZF_DAG_PE_1	UNC13B ROCK1	1.09e-02	64	46	2	PS00479
Domain	ZF_DAG_PE_2	UNC13B ROCK1	1.09e-02	64	46	2	PS50081
Domain	C1	UNC13B ROCK1	1.12e-02	65	46	2	SM00109
Domain	KRAB	ZNF761 ZNF100 ZNF680 ZNF658	1.15e-02	358	46	4	PS50805
Domain	KRAB	ZNF761 ZNF100 ZNF680 ZNF658	1.15e-02	358	46	4	PF01352
Domain	PE/DAG-bd	UNC13B ROCK1	1.15e-02	66	46	2	IPR002219
Domain	BBOX	TRIM37 MEFV	1.25e-02	69	46	2	SM00336
Domain	KRAB	ZNF761 ZNF100 ZNF680 ZNF658	1.27e-02	369	46	4	SM00349
Domain	KRAB	ZNF761 ZNF100 ZNF680 ZNF658	1.29e-02	370	46	4	IPR001909
Domain	-	TRIM37 MEFV	1.32e-02	71	46	2	4.10.45.10
Domain	Prefoldin	URI1 PPFIA3	1.36e-02	72	46	2	IPR009053
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE	PPP1CA PPP1CC	1.57e-04	8	34	2	M47933
Pathway	KEGG_MEDICUS_REFERENCE_CENPE_INTERACTION_WITH_NDC80_COMPLEX	PPP1CA PPP1CC	3.67e-04	12	34	2	M47887
Pathway	KEGG_MEDICUS_REFERENCE_DEPHOSPHORYLATION_OF_KINETOCHORE	PPP1CA PPP1CC	3.67e-04	12	34	2	M47891
Pathway	REACTOME_RHOB_GTPASE_CYCLE	STK10 ROCK1 SLK	6.02e-04	69	34	3	MM15596
Pathway	REACTOME_RHOB_GTPASE_CYCLE	STK10 ROCK1 SLK	6.28e-04	70	34	3	M41806
Pathway	REACTOME_RHOC_GTPASE_CYCLE	STK10 ROCK1 SLK	6.28e-04	70	34	3	MM15597
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_GENOME_REPLICATION_TRANSCRIPTION_AND_TRANSLATION	PPP1CA PPP1CC	6.63e-04	16	34	2	M48235
Pathway	REACTOME_RHOC_GTPASE_CYCLE	STK10 ROCK1 SLK	7.39e-04	74	34	3	M41807
Pathway	REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE	UNC13B PPFIA3	7.51e-04	17	34	2	MM14907
Pathway	REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE	UNC13B PPFIA3	7.51e-04	17	34	2	M93
Pathway	REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE	UNC13B PPFIA3	8.43e-04	18	34	2	M13015
Pathway	REACTOME_SEROTONIN_NEUROTRANSMITTER_RELEASE_CYCLE	UNC13B PPFIA3	8.43e-04	18	34	2	MM14702
Pathway	REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE	UNC13B PPFIA3	8.43e-04	18	34	2	MM14703
Pathway	REACTOME_SEROTONIN_NEUROTRANSMITTER_RELEASE_CYCLE	UNC13B PPFIA3	8.43e-04	18	34	2	M27043
Pathway	WP_FOCAL_ADHESION	DOCK1 ROCK1 PPP1CA PPP1CC	1.28e-03	199	34	4	M39402
Pathway	KEGG_FOCAL_ADHESION	DOCK1 ROCK1 PPP1CA PPP1CC	1.28e-03	199	34	4	M7253
Pathway	REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE	UNC13B PPFIA3	1.38e-03	23	34	2	MM14852
Pathway	REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE	UNC13B PPFIA3	1.38e-03	23	34	2	M12627
Pathway	REACTOME_TRIGLYCERIDE_CATABOLISM	PPP1CA PPP1CC	1.51e-03	24	34	2	M10064
Pathway	REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE	UNC13B PPFIA3	1.51e-03	24	34	2	MM14834
Pathway	REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE	UNC13B PPFIA3	1.51e-03	24	34	2	M630
Pathway	KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	DOCK1 ROCK1 PPP1CA PPP1CC	1.65e-03	213	34	4	M18306
Pathway	REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING	PPP1CA PPP1CC	1.77e-03	26	34	2	M628
Pathway	WP_INTEGRINMEDIATED_CELL_ADHESION	DOCK1 ROCK1 MAPK7	1.87e-03	102	34	3	M39577
Pathway	WP_INTEGRINMEDIATED_CELL_ADHESION	DOCK1 ROCK1 MAPK7	1.87e-03	102	34	3	MM15830
Pathway	KEGG_OOCYTE_MEIOSIS	SLK PPP1CA PPP1CC	2.50e-03	113	34	3	M16817
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	ROCK1 PPP1CA PPP1CC	2.63e-03	115	34	3	M9387
Pubmed	Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene.	PPP1CA PPP1CC	1.87e-06	2	48	2	9882500
Pubmed	PP-1α and PP-1γ display antagonism and differential roles in tumorigenicity of lung cancer cells.	PPP1CA PPP1CC	1.87e-06	2	48	2	23176181
Pubmed	The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.	PPP1CA PPP1CC	5.59e-06	3	48	2	12138106
Pubmed	Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization.	PPP1CA PPP1CC	5.59e-06	3	48	2	7857673
Pubmed	Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.	PPP1CA PPP1CC	5.59e-06	3	48	2	11739654
Pubmed	Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network.	PPP1CA PPP1CC	5.59e-06	3	48	2	19074462
Pubmed	Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1.	PPP1CA PPP1CC	5.59e-06	3	48	2	11588169
Pubmed	Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.	STK10 SLK	5.59e-06	3	48	2	23209304
Pubmed	1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.	PPP1CA PPP1CC	5.59e-06	3	48	2	25073485
Pubmed	Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.	PPP1CA PPP1CC	5.59e-06	3	48	2	21712997
Pubmed	NOM1 targets protein phosphatase I to the nucleolus.	PPP1CA PPP1CC	5.59e-06	3	48	2	17965019
Pubmed	Characterization of protein phosphatases in mouse oocytes.	PPP1CA PPP1CC	5.59e-06	3	48	2	9882488
Pubmed	URI is an oncogene amplified in ovarian cancer cells and is required for their survival.	URI1 PPP1CC	5.59e-06	3	48	2	21397856
Pubmed	Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.	PPP1CA PPP1CC	1.12e-05	4	48	2	23499489
Pubmed	Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.	PPP1CA PPP1CC	1.12e-05	4	48	2	16131488
Pubmed	Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.	PPP1CA PPP1CC	1.12e-05	4	48	2	10194355
Pubmed	Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.	STK10 SLK	1.12e-05	4	48	2	18239682
Pubmed	Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.	PPP1CA PPP1CC	1.12e-05	4	48	2	23277204
Pubmed	NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.	PPP1CA PPP1CC	1.12e-05	4	48	2	10880350
Pubmed	The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.	PPP1CA PPP1CC	1.12e-05	4	48	2	12016225
Pubmed	Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.	PPP1CA PPP1CC	1.12e-05	4	48	2	12221103
Pubmed	Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis.	PPP1CA PPP1CC	1.12e-05	4	48	2	15226296
Pubmed	Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1.	PPP1CA PPP1CC	1.12e-05	4	48	2	22768081
Pubmed	Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.	PPP1CA PPP1CC	1.12e-05	4	48	2	12226088
Pubmed	A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.	STK10 SLK	1.12e-05	4	48	2	27919044
Pubmed	Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.	PPP1CA PPP1CC	1.12e-05	4	48	2	17202132
Pubmed	Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif.	PPP1CA PPP1CC	1.12e-05	4	48	2	10807923
Pubmed	A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand.	PPP1CA PPP1CC	1.12e-05	4	48	2	12036952
Pubmed	N-CoR controls differentiation of neural stem cells into astrocytes.	PPP1CA PPP1CC	1.12e-05	4	48	2	12410313
Pubmed	Synphilin-1A is a phosphoprotein phosphatase 1-interacting protein and affects PPP1 sorting to subcellular compartments.	PPP1CA PPP1CC	1.12e-05	4	48	2	24902662
Pubmed	Nuclear protein phosphatase-1 regulates HIV-1 transcription.	PPP1CA PPP1CC	1.12e-05	4	48	2	12788939
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	DOCK1 SEMA6A MAPK7 DNAAF4	1.14e-05	100	48	4	25807483
Pubmed	SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.	PPP1CA PPP1CC	1.86e-05	5	48	2	20424263
Pubmed	Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms.	URI1 PPP1CC	1.86e-05	5	48	2	27505673
Pubmed	Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions.	PPP1CA PPP1CC	1.86e-05	5	48	2	23197154
Pubmed	Initiation factor 2B activity is regulated by protein phosphatase 1, which is activated by the mitogen-activated protein kinase-dependent pathway in insulin-like growth factor 1-stimulated neuronal cells.	PPP1CA PPP1CC	1.86e-05	5	48	2	12624094
Pubmed	Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.	PPP1CA PPP1CC	1.86e-05	5	48	2	19581931
Pubmed	The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.	PPP1CA PPP1CC	1.86e-05	5	48	2	12016208
Pubmed	Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.	PPP1CA PPP1CC	1.86e-05	5	48	2	22801782
Pubmed	Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle.	PPP1CA PPP1CC	1.86e-05	5	48	2	11551964
Pubmed	The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets.	PPP1CA PPP1CC	1.86e-05	5	48	2	28615442
Pubmed	Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220.	PPP1CA PPP1CC	1.86e-05	5	48	2	10209101
Pubmed	The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.	PPP1CA PPP1CC	1.86e-05	5	48	2	17511879
Pubmed	A PP1-PP2A phosphatase relay controls mitotic progression.	PPP1CA PPP1CC	1.86e-05	5	48	2	25487150
Pubmed	The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.	PPP1CA PPP1CC	1.86e-05	5	48	2	24116158
Pubmed	Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).	PPP1CA PPP1CC	2.79e-05	6	48	2	25785436
Pubmed	Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.	PPP1CA PPP1CC	2.79e-05	6	48	2	21998301
Pubmed	S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling.	URI1 PPP1CC	2.79e-05	6	48	2	17936702
Pubmed	Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins.	PPP1CA PPP1CC	2.79e-05	6	48	2	23088536
Pubmed	Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.	PPP1CA PPP1CC	2.79e-05	6	48	2	18641122
Pubmed	SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1.	PPP1CA PPP1CC	2.79e-05	6	48	2	14640981
Pubmed	Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality.	PPP1CA PPP1CC	3.90e-05	7	48	2	18689497
Pubmed	SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein.	PPP1CA PPP1CC	3.90e-05	7	48	2	17123353
Pubmed	Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells.	PPP1CA PPP1CC	3.90e-05	7	48	2	33537097
Pubmed	A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.	PPP1CA PPP1CC	3.90e-05	7	48	2	12147701
Pubmed	Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex.	PPP1CA PPP1CC	3.90e-05	7	48	2	10637318
Pubmed	A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat.	PPP1CA PPP1CC	5.19e-05	8	48	2	12036313
Pubmed	Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.	PPP1CA PPP1CC	5.19e-05	8	48	2	16262633
Pubmed	The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.	PPP1CA PPP1CC	5.19e-05	8	48	2	21930935
Pubmed	RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits.	PPP1CA PPP1CC	6.67e-05	9	48	2	20926688
Pubmed	Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF.	PPP1CA PPP1CC	6.67e-05	9	48	2	21566083
Pubmed	Molecular and functional architecture of striatal dopamine release sites.	UNC13B PPFIA3	1.02e-04	11	48	2	34767769
Pubmed	PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.	PPP1CA PPP1CC	1.22e-04	12	48	2	10830164
Pubmed	Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.	URI1 PPP1CA	1.44e-04	13	48	2	31738558
Pubmed	Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.	PPP1CA PPP1CC	1.68e-04	14	48	2	16048649
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CEP152 INPP5F SLF2 SH3GL1 PPP1CA CCDC102A CCDC18	1.69e-04	861	48	7	36931259
Pubmed	Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).	PACSIN2 SH3GL1	1.94e-04	15	48	2	25036101
Pubmed	BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.	PPP1CA PPP1CC	1.94e-04	15	48	2	12931191
Pubmed	Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance.	PPP1CA PPP1CC	2.21e-04	16	48	2	17683050
Pubmed	Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer.	PPP1CA PPP1CC	2.21e-04	16	48	2	36484700
Pubmed	Regulation of HIV-1 transcription by protein phosphatase 1.	PPP1CA PPP1CC	2.50e-04	17	48	2	17266553
Pubmed	[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].	PPP1CA PPP1CC	2.50e-04	17	48	2	21351466
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	ASAP3 PPFIA3 TUBD1 SH3GL1	2.57e-04	223	48	4	33187986
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	CEP152 CCDC57 TRIM37	3.74e-04	101	48	3	24613305
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	DOCK1 PPP1CA PPP1CC	3.96e-04	103	48	3	21706016
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	ZC3H7A CEP152 TRAFD1 CCDC18	4.02e-04	251	48	4	29778605
Pubmed	CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP.	ROCK1 PPFIA3	4.23e-04	22	48	2	34187934
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	EVA1C STK10 ROCK1 CEP152 PACSIN2 SH3GL1	4.48e-04	719	48	6	35337019
Pubmed	New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).	PPP1CA PPP1CC	4.63e-04	23	48	2	21360054
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ZC3H7A SLK DDX39B SH3GL1 PPP1CA PPP1CC	4.65e-04	724	48	6	36232890
Pubmed	Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation.	PPP1CA PPP1CC	5.05e-04	24	48	2	27754788
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	STK10 ZC3H7A URI1 TRAFD1 MAPK7 TRIM37 IL33	5.23e-04	1038	48	7	26673895
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	ASAP3 MAPK7 CCDC57 DNAAF4 TRIM37 DDX39B	5.29e-04	742	48	6	26871637
Pubmed	A human MAP kinase interactome.	DOCK1 ZC3H7A GAS7 MAPK7 PACSIN2	5.45e-04	486	48	5	20936779
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PHLPP1 ROCK1 URI1 PPFIA3 PPP1CA PPP1CC CCDC18	5.57e-04	1049	48	7	27880917
Pubmed	Comprehensive Proteomic Analysis of PGC7-Interacting Proteins.	SLK DDX39B PPP1CA PPP1CC	6.64e-04	287	48	4	28712289
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ZC3H7A ZNF658 CCDC57 TUBD1 DDX39B PPP1CA SKIDA1 PPP1CC	7.37e-04	1442	48	8	35575683
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	GAS7 PACSIN2 PPP1CA	7.46e-04	128	48	3	23858473
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	CEP152 SEMA6A SLK	7.80e-04	130	48	3	12421765
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	PPP1CA PPP1CC	8.45e-04	31	48	2	20516061
Pubmed	The synaptic vesicle cycle.	UNC13B PPFIA3	8.45e-04	31	48	2	15217342
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	DOCK1 CEP152 ZNF423 PACSIN2 SH3GL1	8.46e-04	536	48	5	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	DOCK1 CEP152 ZNF423 PACSIN2 SH3GL1	8.60e-04	538	48	5	10512203
Pubmed	A quantitative telomeric chromatin isolation protocol identifies different telomeric states.	PPP1CA PPP1CC	1.02e-03	34	48	2	24270157
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	SLK DDX39B PACSIN2 SH3GL1 PPP1CA	1.07e-03	565	48	5	25468996
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	ASAP3 STK10 ROCK1 SEMA6A PACSIN2	1.10e-03	569	48	5	30639242
Pubmed	ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2.	PPP1CA PPP1CC	1.27e-03	38	48	2	30629181
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	ZNF131 CEP152 ZNF100 INPP5F TRIM37 ZNF423 PACSIN2	1.31e-03	1215	48	7	15146197
Interaction	GYS1 interactions	CEP152 SLK MAPK7 PPP1CA PPP1CC	1.05e-05	125	47	5	int:GYS1
Interaction	PPP1R2C interactions	PPP1CA PPP1CC	3.18e-05	4	47	2	int:PPP1R2C
Interaction	TPTE2 interactions	URI1 TRIM37 SH3GL1 CCDC18	4.37e-05	84	47	4	int:TPTE2
Interaction	PPP2R5C interactions	PPFIA3 PACSIN2 PPP1CA PPP1CC	5.02e-05	87	47	4	int:PPP2R5C
Interaction	CSRNP2 interactions	PPP1CA PPP1CC	5.30e-05	5	47	2	int:CSRNP2
Interaction	SPAG1 interactions	ATL3 DDX39B PPP1CC	5.62e-05	32	47	3	int:SPAG1
Interaction	KIFBP interactions	ZC3H7A SLK SH3GL1 PPP1CA PPP1CC	6.09e-05	180	47	5	int:KIFBP
Interaction	KRT222 interactions	ASAP3 CEP152 CCDC102A	7.38e-05	35	47	3	int:KRT222
Interaction	SFRP5 interactions	PPP1CA PPP1CC	7.94e-05	6	47	2	int:SFRP5
Interaction	MYPN interactions	PHLPP1 PPP1CA PPP1CC	1.11e-04	40	47	3	int:MYPN
Interaction	MT1E interactions	CCDC57 TRIM37	1.11e-04	7	47	2	int:MT1E
Interaction	LINC02370 interactions	UNC13B PACSIN2	1.48e-04	8	47	2	int:LINC02370
Interaction	PFN1 interactions	DOCK1 PHLPP1 CEP152 INPP5F TRIM37 DDX39B PPP1CA	1.65e-04	509	47	7	int:PFN1
Interaction	RPAP3 interactions	PHLPP1 SLK URI1 PPP1CA PPP1CC	1.74e-04	225	47	5	int:RPAP3
Interaction	MAP7D3 interactions	PHLPP1 ZC3H7A TRIM37 PPP1CC	1.92e-04	123	47	4	int:MAP7D3
Interaction	SH2D4A interactions	PHLPP1 SH3GL1 PPP1CA PPP1CC	2.05e-04	125	47	4	int:SH2D4A
Interaction	SYCE1 interactions	ROCK1 CEP152 CCDC102A CCDC18	2.18e-04	127	47	4	int:SYCE1
GeneFamily	Glycosyl transferases group 1 domain containing	ALG1L2 ALG1	1.44e-04	10	33	2	427
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP1CA PPP1CC	2.49e-04	13	33	2	693
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	RLF ZNF131 ZNF761 ZNF100 ZNF680 ZNF658 ZNF423	2.62e-04	718	33	7	28
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	GAS7 PACSIN2	7.98e-04	23	33	2	1288
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ASAP3 PHLPP1 ROCK1	6.18e-03	206	33	3	682
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	DOCK1 RLF PHLPP1 STK10 ROCK1 SLK URI1 INPP5F TRIM37	1.81e-05	856	47	9	M4500
Coexpression	GSE36392_MAC_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP	STK10 INPP5F MAPK7 TRIM37 CCDC102A	2.91e-05	200	47	5	M5285
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Vein\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ASAP3 EVA1C SEMA6A IL33 ZNF423	1.78e-06	192	47	5	81baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ASAP3 EVA1C SEMA6A IL33 ZNF423	1.78e-06	192	47	5	52acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GAS7 SEMA6A IL33 ZNF423	4.77e-05	190	47	4	876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCell	COVID-19-lung-Vein_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	EVA1C SEMA6A IL33 ZNF423	4.77e-05	190	47	4	1caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GAS7 SEMA6A IL33 ZNF423	4.77e-05	190	47	4	be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GAS7 SEMA6A IL33 ZNF423	4.77e-05	190	47	4	09a8855901c3c9332dbaab3e40166485b696d0f1
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Vein\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ASAP3 EVA1C IL33 ZNF423	4.97e-05	192	47	4	717f3d3bbee4d0f64ba1341ee2b00a407ba1e0f3
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EVA1C SEMA6A IL33 ZNF423	5.07e-05	193	47	4	7261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCell	Endothelial-endothelial_cell_of_vein\|World / Lineage, Cell type, age group and donor	EVA1C SEMA6A IL33 ZNF423	5.17e-05	194	47	4	3cbd9622a68e89add90e589867d88c83c5a33476
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EVA1C SEMA6A IL33 ZNF423	5.17e-05	194	47	4	fc2e0081005c0c496e41197a2d06e4a37708221f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EVA1C PHLPP1 STK10 ZNF423	5.49e-05	197	47	4	412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell	Hematolymphoid-Endothelial-NOSTRIN\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK1 UNC13B EVA1C ZNF423	5.82e-05	200	47	4	032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHLPP1 GAS7 SLC24A2 IL33	5.82e-05	200	47	4	0e85c90719d9ec51a566e230c9dd2909d8df1f52
ToppCell	Hematolymphoid-Endothelial-NOSTRIN--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK1 UNC13B EVA1C ZNF423	5.82e-05	200	47	4	7fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAS7 SEMA6A SLC24A2 IL33	5.82e-05	200	47	4	e5b4821fff40566c4a7dc3f74a14e27eb06b165d
ToppCell	Hematolymphoid-Endothelial-NOSTRIN---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK1 UNC13B EVA1C ZNF423	5.82e-05	200	47	4	68fce28690246895fd33354b30960ebcc31aa4cc
ToppCell	Hematolymphoid-Endothelial-NOSTRIN-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK1 UNC13B EVA1C ZNF423	5.82e-05	200	47	4	376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCell	Hematolymphoid-Endothelial-NOSTRIN----L2-6\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK1 UNC13B EVA1C ZNF423	5.82e-05	200	47	4	878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCell	Hematolymphoid-Endothelial\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK1 UNC13B EVA1C ZNF423	5.82e-05	200	47	4	7136936d05ab344a560cf159684c881063b5430d
Disease	congenital disorder of glycosylation Ik (implicated_via_orthology)	ALG1L2 ALG1	7.44e-06	3	47	2	DOID:0080563 (implicated_via_orthology)
Disease	congenital disorder of glycosylation (implicated_via_orthology)	ALG1L2 ALG1	3.71e-05	6	47	2	DOID:5212 (implicated_via_orthology)
Disease	congenital disorder of glycosylation type I (implicated_via_orthology)	ALG1L2 ALG1	2.57e-04	15	47	2	DOID:0050570 (implicated_via_orthology)
Disease	Neoplasms, Experimental	URI1 MAPK7	4.99e-03	66	47	2	C0027659
Disease	mean corpuscular hemoglobin concentration	ZNF131 SLK HBE1 MEFV CCDC102A DYRK3	7.88e-03	1105	47	6	EFO_0004528
Disease	acute myeloid leukemia (is_implicated_in)	MEFV SH3GL1	7.97e-03	84	47	2	DOID:9119 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ETALDIARKKHHKEC	ASAP3	656	Q8TDY4
IARKKHHKECEELLE	ASAP3	661	Q8TDY4
LKDCHKKIEDLHQVK	CEP152	571	O94986
AVNFKCLHELVKHEE	ALG1	391	Q9BT22
VNFKCLHELVKHEEN	ALG1L2	176	C9J202
NLKHIKHFILDECDK	DDX39B	186	Q13838
KCLHELVKHEENGLV	ALG1L	91	Q6GMV1
LKHFKHDNIIAIKDI	MAPK7	106	Q13164
FAKLSELHCDKLHVD	HBE1	86	P02100
LKSLFEHHKALDEKV	PPFIA3	156	O75145
KRHLKQVQLLFCEDH	MEFV	376	O15553
VVAKFLHKHDLDLIC	PPP1CA	231	P62136
KKAHHAACKEEKLAI	PACSIN2	156	Q9UNF0
DQELKLHCHESKFLN	EVA1C	171	P58658
ANNKEHSVELHKCEK	IL33	196	O95760
KVLFDKILLEHCRKH	DOCK1	1146	Q14185
HEKICLAFEKAKKIH	CCDC18	626	Q5T9S5
LFEKNKELADLKHVH	CCDC102A	411	Q96A19
HKFKTLEKHLEDVLD	CCDC57	591	Q2TAC2
KHCEFKQLALDHFKK	ATL3	386	Q6DD88
AACHLKLKNLHKAIE	DNAAF4	331	Q8WXU2
ECHTHEEKKAKLLEI	GCNA	86	Q96QF7
DLFLHHKKAISEAKL	SCGN	136	O76038
DLELELCKKHHFGIN	INPP5F	101	Q9Y2H2
LHKNKIIHCDLKPEN	DYRK3	326	O43781
EKDKCENHHEKLSVF	TRIM37	91	O94972
KCDFEFKAKHRIAHK	URI1	166	O94763
EKCHLLVEHETQKLK	SLK	1151	Q9H2G2
QHCDLELSILKLKEH	TRAFD1	91	O14545
LHKIAKKKCHVDENE	SLC24A2	386	Q9UI40
KKCDHHIADLRKQLA	GAS7	316	O60861
KHHCDLEELRKLKAI	SKIDA1	56	Q1XH10
KHFVLLCGALEKHVK	SLF2	1111	Q8IX21
LLLHENDAIHKICAK	TUBD1	201	Q9UJT1
SVDECKVHKEHDNKL	ZNF100	151	Q8IYN0
LCEKDLKEIQHHLKK	SH3GL1	146	Q99961
RKHQIIHLADKYKCD	ZNF761	231	Q86XN6
NHKQKHDDLRYKCEL	RLF	761	Q13129
EKVLKEIDSHCHLRK	SAGE2P	591	A6NJ88
GKHKDECHNFIKVLL	SEMA6A	111	Q9H2E6
EKCHLLVEHETQKLK	STK10	886	O94804
KYALEEHEKDHLCKS	UNC13B	1016	O14795
VVAKFLHKHDLDLIC	PPP1CC	231	P36873
VKCHRDHLDKKEDLI	ROCK1	1266	Q13464
EKLQLDIKHEKAHAE	ZNF658	171	Q5TYW1
TYHANIDHKCKKDIL	ZC3H7A	461	Q8IWR0
KVEEVKKHQHCLAFS	PHLPP1	591	O60346
ELQLSHVKDLFHCEK	ZNF131	251	P52739
LLEKHLREKHCVFDA	ZNF423	821	Q2M1K9
HKKIHIEEKPFKCEE	ZNF680	256	Q8NEM1