Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	deSUMOylase activity	SENP1 SENP2 USPL1	2.41e-05	7	179	3	GO:0016929
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP34 USP18 USP28 SENP1 PAN2 SENP2 TNFAIP3 USPL1	3.33e-05	137	179	8	GO:0019783
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	TPO CYP1A2 DBH KDM4E PTGS2 PAM BBOX1 KDM6A UTY	6.57e-05	194	179	9	GO:0016705
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	NSUN4 ERCC6 DIS3L ATAD5 POLR2A MRPL44 DHX38 MEIOB METTL4 ANKZF1 DHX8 YARS2 SLFN12L SMARCA2 PAN2 PRORP	2.38e-04	645	179	16	GO:0140640
GeneOntologyMolecularFunction	dioxygenase activity	TDO2 KDM4E PTGS2 BBOX1 KDM6A UTY	2.54e-04	98	179	6	GO:0051213
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP34 USP18 USP28 SENP1 PAN2 SENP2 TNFAIP3 USPL1	3.48e-04	192	179	8	GO:0008234
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	NSUN4 DIS3L POLR2A MRPL44 DHX38 METTL4 ANKZF1 DHX8 YARS2 SLFN12L PAN2 PRORP	3.96e-04	417	179	12	GO:0140098
GeneOntologyMolecularFunction	demethylase activity	CYP1A2 KDM4E KDM6A UTY	6.41e-04	44	179	4	GO:0032451
GeneOntologyMolecularFunction	ubiquitin-like protein-specific endopeptidase activity	SENP1 SENP2	7.85e-04	5	179	2	GO:0070137
GeneOntologyMolecularFunction	SUMO-specific endopeptidase activity	SENP1 SENP2	7.85e-04	5	179	2	GO:0070139
GeneOntologyMolecularFunction	histone H3K27me2/H3K27me3 demethylase activity	KDM6A UTY	7.85e-04	5	179	2	GO:0071558
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	DBH PAM	7.85e-04	5	179	2	GO:0016715
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	DIS3L ACHE MRPL44 MEIOB ACOT1 ANKZF1 PTER PRDX6 SLFN12L MTMR6 MYG1 PAFAH2 PPM1L PAN2 PLD2 PRORP LRRC18	9.74e-04	807	179	17	GO:0016788
GeneOntologyCellularComponent	caveola	ERBB4 LRRK2 IRS1 PTCH1 PTGS2 TGFBR2 LRP6 PLD2	5.59e-06	111	181	8	GO:0005901
GeneOntologyCellularComponent	plasma membrane raft	ERBB4 LRRK2 IRS1 PTCH1 PTGS2 TGFBR2 LRP6 PLD2	4.33e-05	147	181	8	GO:0044853
GeneOntologyCellularComponent	spectrin	SPTA1 SPTB SPTBN5	5.16e-05	9	181	3	GO:0008091
GeneOntologyCellularComponent	membrane raft	DPP4 ERBB4 LRRK2 IRS1 PTCH1 PTGS2 TGFBR2 FCER1A LRP6 PLD2 DMD	3.30e-04	362	181	11	GO:0045121
GeneOntologyCellularComponent	membrane microdomain	DPP4 ERBB4 LRRK2 IRS1 PTCH1 PTGS2 TGFBR2 FCER1A LRP6 PLD2 DMD	3.46e-04	364	181	11	GO:0098857
Domain	Spectrin	SPTA1 SPTB ACTN1 SPTBN5 DMD	1.95e-06	23	174	5	PF00435
Domain	Spectrin_repeat	SPTA1 SPTB ACTN1 SPTBN5 DMD	6.56e-06	29	174	5	IPR002017
Domain	SPEC	SPTA1 SPTB ACTN1 SPTBN5 DMD	1.09e-05	32	174	5	SM00150
Domain	Spectrin/alpha-actinin	SPTA1 SPTB ACTN1 SPTBN5 DMD	1.09e-05	32	174	5	IPR018159
Domain	ACTININ_2	SPTB ACTN1 SPTBN5 DMD	5.61e-05	23	174	4	PS00020
Domain	ACTININ_1	SPTB ACTN1 SPTBN5 DMD	5.61e-05	23	174	4	PS00019
Domain	Actinin_actin-bd_CS	SPTB ACTN1 SPTBN5 DMD	5.61e-05	23	174	4	IPR001589
Domain	Cu2_ascorb_mOase_CS-2	DBH PAM	8.63e-05	2	174	2	IPR014783
Domain	Cu2_monoox_C	DBH PAM	2.57e-04	3	174	2	IPR024548
Domain	Cu2_ascorb_mOase_N	DBH PAM	2.57e-04	3	174	2	IPR000323
Domain	Cu2_monoox_C	DBH PAM	2.57e-04	3	174	2	PF03712
Domain	CU2_MONOOXYGENASE_1	DBH PAM	2.57e-04	3	174	2	PS00084
Domain	CU2_MONOOXYGENASE_2	DBH PAM	2.57e-04	3	174	2	PS00085
Domain	RFX1_trans_act	RFX2 RFX3	2.57e-04	3	174	2	IPR007668
Domain	Cu2_ascorb_mOase_CS-1	DBH PAM	2.57e-04	3	174	2	IPR020611
Domain	PHM/PNGase_F_dom	DBH PAM	2.57e-04	3	174	2	IPR008977
Domain	Cu2_monooxygen	DBH PAM	2.57e-04	3	174	2	PF01082
Domain	Cu2_ascorb_mOase-like_C	DBH PAM	2.57e-04	3	174	2	IPR014784
Domain	-	DBH PAM	2.57e-04	3	174	2	2.60.120.230
Domain	RFX1_trans_act	RFX2 RFX3	2.57e-04	3	174	2	PF04589
Domain	-	DBH PAM	2.57e-04	3	174	2	2.60.120.310
Domain	USP_3	USP34 USP18 USP28 PAN2 USPL1	5.60e-04	72	174	5	PS50235
Domain	USP_dom	USP34 USP18 USP28 PAN2 USPL1	5.60e-04	72	174	5	IPR028889
Domain	Peptidase_C19_UCH	USP34 USP18 USP28 PAN2 USPL1	5.60e-04	72	174	5	IPR001394
Domain	DOCK_N	DOCK1 DOCK5	8.47e-04	5	174	2	PF16172
Domain	DOCK_N	DOCK1 DOCK5	8.47e-04	5	174	2	IPR032376
Domain	Acyltransf_C	AGPAT3 AGPAT4	8.47e-04	5	174	2	PF16076
Domain	Acyltransf_C	AGPAT3 AGPAT4	8.47e-04	5	174	2	IPR032098
Domain	6-blade_b-propeller_TolB-like	TENM3 LGI3 LRP6 PAM	8.75e-04	46	174	4	IPR011042
Domain	TPR_REGION	APPBP2 DNAH10 ZFC3H1 INTS8 ZC3H7A KDM6A UTY	9.13e-04	165	174	7	PS50293
Domain	TPR	APPBP2 DNAH10 ZFC3H1 INTS8 ZC3H7A KDM6A UTY	9.13e-04	165	174	7	PS50005
Domain	Leu-rich_rpt	LRIT2 LRRIQ3 LRRK2 LRRTM3 IGSF10 NISCH LGI3 NLRP4 LRRC18	1.02e-03	271	174	9	IPR001611
Domain	L_dom-like	LRIT2 ERBB4 LRRIQ3 LRRK2 LRRTM3 IGSF10 NISCH LGI3 NLRP4 LRRC18	1.04e-03	328	174	10	IPR032675
Domain	Quino_amine_DH_bsu	LRRK2 BRWD3 ANAPC4	1.07e-03	22	174	3	IPR011044
Domain	EFhand_Ca_insen	SPTA1 ACTN1	1.26e-03	6	174	2	PF08726
Domain	EF-hand_Ca_insen	SPTA1 ACTN1	1.26e-03	6	174	2	IPR014837
Domain	ARM-type_fold	DOCK1 USP34 SMG1 ARMC12 SARM1 LRRK2 ITPR2 DOCK5 PIK3C2B IQCB1	1.33e-03	339	174	10	IPR016024
Domain	JmjC	KDM4E KDM6A UTY	1.39e-03	24	174	3	PF02373
Domain	PH	DOK1 CDC42BPA RASA3 IRS1 SPTBN5 BMX OSBPL3 PLD2	1.40e-03	229	174	8	PF00169
Domain	TPR-like_helical_dom	APPBP2 USP28 ZFC3H1 INTS8 AAR2 ZC3H7A KDM6A UTY	1.56e-03	233	174	8	IPR011990
Pubmed	Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.	DOCK1 DOCK5 PLD2	5.52e-07	4	181	3	23362269
Pubmed	Fine mapping of the human pentraxin gene region on chromosome 1q23.	SPTA1 PTGS2 FCER1A	5.52e-07	4	181	3	8613143
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DNAH10 TUBB8 SPTA1 SPTB ZFC3H1 SPTBN5 TENM3 GAN DMD	6.57e-07	187	181	9	26460568
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DMXL2 CDC42BPA MYO5A ATAD5 AHCTF1 MRPL37 MRPL44 MRPS27 GRB2 FASTKD5 ACOT1 ZFC3H1 NCLN LGALS3BP AAR2 ITPR2 TTLL12 GRAMD1B ZC3H7A SENP1 NISCH SENP2 OGA SF3B2	9.21e-07	1487	181	24	33957083
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	NSUN4 ERCC6 CDC42BPA SFSWAP MYO5A ATAD5 TUBB8 AHCTF1 POLR2A DHX38 RAB22A MRPS27 RDH13 ACTN1 ZFC3H1 PFKL ANKZF1 INTS8 DHX8 ZC3H7A EIF4E SMARCA2 RRP7A KIF22	1.04e-06	1497	181	24	31527615
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	ATP8B1 PFKL LGALS3BP TTLL7 FOXRED2 TENM3 NISCH SVIL EIF4E MED12L UTY	4.38e-06	371	181	11	15747579
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	USP34 ERBB4 ERCC6 SFSWAP DIS3L ATAD5 AHCTF1 POLR2A GRB2 FASTKD5 BRWD3 LGALS3BP SENP1 COQ8A OSBPL3 SMARCA2 SMARCC2 ANAPC4 TCTN2	6.47e-06	1116	181	19	31753913
Pubmed	Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.	KREMEN1 ITPR2 STAB1 NISCH	6.95e-06	24	181	4	20935629
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	SPTA1 SPTB GRB2 SPTBN5	8.24e-06	25	181	4	8493579
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	DOCK1 BIN1 RAB1C AGPAT4 GRB2 BMX PIK3C2B TGDS SMARCC2 KIF22	9.71e-06	329	181	10	17474147
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ERBB4 CDC42BPA IRS1 CDK14 PTER PRAG1 TTLL12 BMX PIK3C2B OSBPL3 SVIL IQCB1 ZNF286B GAN TNFAIP3 NUP93	1.25e-05	861	181	16	36931259
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP34 DMXL2 BIN1 MYO5A DIS3L USP28 SPTB ACOT1 ACTN1 ZFC3H1 INTS8 BRWD3 STAB1 TTLL12 NISCH LGI3 ARIH2 USPL1 KDM6A SF3B2	1.35e-05	1285	181	20	35914814
Pubmed	Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.	POLR2A SMARCA2 SMARCC2	1.62e-05	10	181	3	11238380
Pubmed	Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions.	SPTB ACTN1 DMD	1.62e-05	10	181	3	14627610
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	USP34 ANPEP FKBP9 MR1 NCLN GALNT7 LGALS3BP ITPR2 GRAMD1B IGSF10 PLA2R1 FOXRED2 TENM3 FKTN SVIL PPM1L LRP6 PAM ALG12	1.80e-05	1201	181	19	35696571
Pubmed	SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome.	DOK1 GRB2 IRS1 BMX	2.28e-05	32	181	4	22974441
Pubmed	Diagnostic role of markers dipeptidyl peptidase IV and thyroid peroxidase in thyroid tumors.	TPO DPP4	2.69e-05	2	181	2	12820316
Pubmed	Beta-spectrin Promiss-ao: a translation initiation codon mutation of the beta-spectrin gene (ATG --> GTG) associated with hereditary spherocytosis and spectrin deficiency in a Brazilian family.	SPTA1 SPTB	2.69e-05	2	181	2	9414314
Pubmed	Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia.	SPTA1 SPTB	2.69e-05	2	181	2	9005995
Pubmed	SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis.	SENP1 SENP2	2.69e-05	2	181	2	24048451
Pubmed	The elucidation of novel SH2 binding sites on PLD2.	GRB2 PLD2	2.69e-05	2	181	2	16407827
Pubmed	Deubiquitinating enzyme A20 negatively regulates NF-κB signaling in skeletal muscle in mdx mice.	TNFAIP3 DMD	2.69e-05	2	181	2	22012122
Pubmed	Nuclear localization of CD26 induced by a humanized monoclonal antibody inhibits tumor cell growth by modulating of POLR2A transcription.	DPP4 POLR2A	2.69e-05	2	181	2	23638030
Pubmed	Phospholipase D2 mediates signaling by ATPase class I type 8B membrane 1.	ATP8B1 PLD2	2.69e-05	2	181	2	23213138
Pubmed	An insertional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin nice (beta 220/216).	SPTA1 SPTB	2.69e-05	2	181	2	2070088
Pubmed	Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.	KDM6A UTY	2.69e-05	2	181	2	18434530
Pubmed	The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.	ERCC6 PGBD3	2.69e-05	2	181	2	22483866
Pubmed	Thrombosis and secondary hemochromatosis play major roles in the pathogenesis of jaundiced and spherocytic mice, murine models for hereditary spherocytosis.	SPTA1 SPTB	2.69e-05	2	181	2	9373273
Pubmed	Spectrin mutations in hereditary elliptocytosis and hereditary spherocytosis.	SPTA1 SPTB	2.69e-05	2	181	2	8844207
Pubmed	Positive and negative selection on mammalian Y chromosomes.	KDM6A UTY	2.69e-05	2	181	2	15758204
Pubmed	Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis.	SPTA1 SPTB	2.69e-05	2	181	2	2346784
Pubmed	What role (if any) does the highly conserved CSB-PGBD3 fusion protein play in Cockayne syndrome?	ERCC6 PGBD3	2.69e-05	2	181	2	23369858
Pubmed	Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.	LRRK2 LRP6	2.69e-05	2	181	2	27013965
Pubmed	Properties of human red cell spectrin heterodimer (side-to-side) assembly and identification of an essential nucleation site.	SPTA1 SPTB	2.69e-05	2	181	2	1634521
Pubmed	Synergistic action of DPIV and APN in the regulation of T cell function.	DPP4 ANPEP	2.69e-05	2	181	2	12675232
Pubmed	Cloning of a cDNA encoding a 190-kDa insulin receptor substrate-1-like protein of simian COS cells.	GRB2 IRS1	2.69e-05	2	181	2	7488107
Pubmed	Knockdown of Brm and Baf170, Components of Chromatin Remodeling Complex, Facilitates Reprogramming of Somatic Cells.	SMARCA2 SMARCC2	2.69e-05	2	181	2	26121422
Pubmed	A deletional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin Tokyo (beta 220/216).	SPTA1 SPTB	2.69e-05	2	181	2	1391962
Pubmed	An H-YDb epitope is encoded by a novel mouse Y chromosome gene.	KDM6A UTY	2.69e-05	2	181	2	8944031
Pubmed	The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function.	SENP1 SENP2	2.69e-05	2	181	2	24196834
Pubmed	Chaperone activity and prodan binding at the self-associating domain of erythroid spectrin.	SPTA1 SPTB	2.69e-05	2	181	2	15492010
Pubmed	Beta spectrin kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1.	SPTA1 SPTB	2.69e-05	2	181	2	8102379
Pubmed	Identification of the molecular defect in the erythrocyte membrane skeleton of some kindreds with hereditary spherocytosis.	SPTA1 SPTB	2.69e-05	2	181	2	7104494
Pubmed	A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis.	SPTA1 SPTB	2.69e-05	2	181	2	6215583
Pubmed	Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex.	ERCC6 PGBD3	2.69e-05	2	181	2	21143350
Pubmed	Spectrin Nice (beta 220/216): a shortened beta-chain variant associated with an increase of the alpha I/74 fragment in a case of elliptocytosis.	SPTA1 SPTB	2.69e-05	2	181	2	3580577
Pubmed	Recurrent fatal hydrops fetalis associated with a nucleotide substitution in the erythrocyte beta-spectrin gene.	SPTA1 SPTB	2.69e-05	2	181	2	7883966
Pubmed	Spectrin Cosenza: a novel beta chain variant associated with Sp alphaI/74 hereditary elliptocytosis.	SPTA1 SPTB	2.69e-05	2	181	2	9163587
Pubmed	Identification of three novel spectrin alpha I/74 mutations in hereditary elliptocytosis: further support for a triple-stranded folding unit model of the spectrin heterodimer contact site.	SPTA1 SPTB	2.69e-05	2	181	2	8018926
Pubmed	Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation.	DPP4 ANPEP	2.69e-05	2	181	2	16778789
Pubmed	The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF.	GRB2 PLD2	2.69e-05	2	181	2	17276458
Pubmed	High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells.	DPP4 MR1	2.69e-05	2	181	2	25752900
Pubmed	Erythrocyte spectrin is comprised of many homologous triple helical segments.	SPTA1 SPTB	2.69e-05	2	181	2	6472478
Pubmed	An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.	ERCC6 PGBD3	2.69e-05	2	181	2	18369450
Pubmed	Cyclooxygenase-2 or tumor necrosis factor-α inhibitors attenuate the mechanotransductive effects of pulsed focused ultrasound to suppress mesenchymal stromal cell homing to healthy and dystrophic muscle.	PTGS2 DMD	2.69e-05	2	181	2	25534849
Pubmed	Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer.	KDM6A UTY	2.69e-05	2	181	2	27533081
Pubmed	Novel mutations in SPTA1 and SPTB identified by whole exome sequencing in eight Thai families with hereditary pyropoikilocytosis presenting with severe fetal and neonatal anaemia.	SPTA1 SPTB	2.69e-05	2	181	2	30198572
Pubmed	Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant in a kindred with hereditary elliptocytosis. Characterization of the molecular defect as exon skipping due to a splice site mutation.	SPTA1 SPTB	2.69e-05	2	181	2	2056132
Pubmed	Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation.	KDM6A UTY	2.69e-05	2	181	2	31097364
Pubmed	Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation.	DPP4 ANPEP	2.69e-05	2	181	2	16700521
Pubmed	Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer.	SENP1 SENP2	2.69e-05	2	181	2	27178176
Pubmed	Recruitment of the putative transcription-repair coupling factor CSB/ERCC6 to RNA polymerase II elongation complexes.	ERCC6 POLR2A	2.69e-05	2	181	2	9372911
Pubmed	Spectrin cagliari. an Ala-->Gly substitution in helix 1 of beta spectrin repeat 17 that severely disrupts the structure and self-association of the erythrocyte spectrin heterodimer.	SPTA1 SPTB	2.69e-05	2	181	2	8226774
Pubmed	Glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis.	SPTA1 SPTB	2.69e-05	2	181	2	22164239
Pubmed	Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex.	SPTA1 SPTB	2.69e-05	2	181	2	20197550
Pubmed	A structural model of the erythrocyte spectrin heterodimer initiation site determined using homology modeling and chemical cross-linking.	SPTA1 SPTB	2.69e-05	2	181	2	17977835
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	SFSWAP DIS3L MRPL37 POLR2A MRPL44 MRPS27 GRB2 DHX8 ZC3H7A EIF4E SMARCC2 RRP7A SF3B2 KIF22	2.84e-05	723	181	14	34133714
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	USP18 DMXL2 CDC42BPA DNAH10 TUBB8 POLR2A GRB2 IRS1 CHI3L2 MTMR6 SENP1 ARIH2 SMARCA2 SENP2	3.15e-05	730	181	14	34857952
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	EFCAB5 CDC42BPA MYO5A SENP1 SMARCC2 DMD UTY SF3B2	3.35e-05	234	181	8	36243803
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CDC42BPA MYO5A ATAD5 POLR2A DHX38 GRB2 CNTROB ITPR2 MTMR6 SVIL PPM1L LRP6 SENP2 NUP93 DMD KDM6A KIF22	3.77e-05	1049	181	17	27880917
Pubmed	Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation.	BIN1 BMX SMARCA2	3.82e-05	13	181	3	15207703
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SMG1 DMXL2 DHX38 PFKL NCLN ANKZF1 TTLL12 DOCK5 COQ8A OSBPL3 NISCH PAM SF3B2	3.97e-05	650	181	13	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 MYO5A AHCTF1 POLR2A DHX38 ACTN1 DHX8 TTLL12 SMARCA2 SMARCC2 RRP7A NUP93 SF3B2	4.16e-05	653	181	13	22586326
Pubmed	Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.	POLR2A SMARCA2 SMARCC2	4.84e-05	14	181	3	8895581
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	TUBB8 POLR2A DHX38 MRPS27 GRB2 RDH13 ACTN1 PFKL NCLN ANKZF1 PTER PRDX6 LGALS3BP DHX8 YARS2 AAR2 EIF4E SMARCC2 KLHDC10 SF3B2	5.25e-05	1415	181	20	28515276
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	USP34 AHCTF1 DHX38 PFKL PTCH1 GALNT7 PTGS2 TBCCD1 SLFN12L MTMR6 COQ8A OSBPL3 PAN2 TNFAIP3 KLHDC10 NLRP4 LRRC18	5.65e-05	1084	181	17	11544199
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DMXL2 DIS3L DHX38 SARM1 MRPS27 ZFC3H1 PRDX6 OSBPL3 ZNF286B PRORP KLHDC10	6.01e-05	493	181	11	15368895
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DMXL2 BIN1 MYO5A SPTA1 SPTB FKBP9 GRB2 ACTN1 PFKL PTGS2 PRDX6 ITPR2 GRAMD1B NISCH LGI3 SVIL EIF4E SMARCC2 DMD CNTN1	6.13e-05	1431	181	20	37142655
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 CDC42BPA RASA3 POLR2A IRS1 NCLN PTCH1 PRAG1 CNTROB ITPR2 PIK3C2B NISCH DISP2 SENP2 TNFAIP3 HAS3 MYRF	7.14e-05	1105	181	17	35748872
Pubmed	A human RNA polymerase II complex containing factors that modify chromatin structure.	POLR2A SMARCA2 SMARCC2	7.39e-05	16	181	3	9710619
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	APPBP2 DHX38 MRPS27 STAB1 KLHDC10	7.55e-05	83	181	5	9039502
Pubmed	ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells.	ERBB4 PTGS2	8.05e-05	3	181	2	20585313
Pubmed	Participation of myosin Va and Pka type I in the regeneration of neuromuscular junctions.	MYO5A DMD	8.05e-05	3	181	2	22815846
Pubmed	Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans.	ERCC6 PGBD3	8.05e-05	3	181	2	23028371
Pubmed	SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response.	USP28 SENP1	8.05e-05	3	181	2	30622440
Pubmed	Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.	RFX2 RFX3	8.05e-05	3	181	2	10330134
Pubmed	The orphan nuclear receptor ROR alpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9.	CYP1A2 MYO5A	8.05e-05	3	181	2	7490103
Pubmed	Ciliogenic RFX transcription factors regulate FGF1 gene promoter.	RFX2 RFX3	8.05e-05	3	181	2	22415835
Pubmed	The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding.	SPTA1 SPTB	8.05e-05	3	181	2	20585040
Pubmed	A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.	GRB2 IRS1	8.05e-05	3	181	2	12679424
Pubmed	Upregulation of fibronectin expression by COX-2 is mediated by interaction with ELMO1.	DOCK1 PTGS2	8.05e-05	3	181	2	20732417
Pubmed	Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.	RFX2 RFX3	8.05e-05	3	181	2	12403718
Pubmed	The UTX gene escapes X inactivation in mice and humans.	KDM6A UTY	8.05e-05	3	181	2	9499428
Pubmed	ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation.	GRB2 IRS1	8.05e-05	3	181	2	12173038
Pubmed	Identification of the major SHPTP2-binding protein that is tyrosine-phosphorylated in response to insulin.	GRB2 IRS1	8.05e-05	3	181	2	7629070
Pubmed	Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.	RFX2 RFX3	8.05e-05	3	181	2	32725242
Pubmed	Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways.	EPOR GRB2	8.05e-05	3	181	2	7534299
Pubmed	Spectrin's E2/E3 ubiquitin conjugating/ligating activity is diminished in sickle cells.	SPTA1 SPTB	8.05e-05	3	181	2	15929114
Pubmed	TGF-β2 induces Grb2 to recruit PI3-K to TGF-RII that activates JNK/AP-1-signaling and augments invasiveness of Theileria-transformed macrophages.	GRB2 TGFBR2	8.05e-05	3	181	2	26511382
Pubmed	Inherited hemolytic disease in mice: a review and update.	SPTA1 SPTB	8.05e-05	3	181	2	6763106
Interaction	IRAK2 interactions	SARM1 FASTKD5 TGFBR2 SENP1 COQ8A IQCB1 TNFAIP3	1.80e-06	66	177	7	int:IRAK2
GeneFamily	EF-hand domain containing\|Spectrins	SPTA1 SPTB SPTBN5	1.08e-05	7	124	3	1113
GeneFamily	Ubiquitin specific peptidases	USP34 USP18 USP28 PAN2 USPL1	4.04e-05	56	124	5	366
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM4E KDM6A UTY	5.74e-04	24	124	3	485
GeneFamily	SUMO specific peptidases	SENP1 SENP2	9.58e-04	7	124	2	984
GeneFamily	Regulatory factor X family	RFX2 RFX3	1.27e-03	8	124	2	1153
GeneFamily	1-acylglycerol-3-phosphate O-acyltransferases	AGPAT3 AGPAT4	2.46e-03	11	124	2	46
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 TTLL7 IGSF10 TGFBR2 PLA2R1 PIK3C2B PAM C1QTNF1	7.61e-07	180	181	8	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 TTLL7 IGSF10 TGFBR2 PLA2R1 PIK3C2B PAM C1QTNF1	7.61e-07	180	181	8	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CFAP251 RASA3 ACTN1 PTGS2 PLA2R1 TENM3 DMD CNTN1	1.01e-06	187	181	8	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP4 ANPEP FKBP9 ATP8B1 PTGS2 IGSF10 TGFBR2 C1QTNF1	1.24e-06	192	181	8	beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCell	NS-moderate-d_16-33-Epithelial-Secretory\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CDC42BPA ATP8B1 GALNT7 LGALS3BP PLA2R1 PPM1L PAM GAN	1.44e-06	196	181	8	70384c1da9baed843f414cfd1403ddd586a2db07
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK1 DNAH10 FKBP9 ADAMTSL3 IGSF10 TENM3 PAM DMD	1.44e-06	196	181	8	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK1 DNAH10 FKBP9 ADAMTSL3 IGSF10 TENM3 PAM DMD	1.44e-06	196	181	8	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	10x3'2.3-week_12-13-Hematopoietic\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	EPOR ACHE SPTA1 SPTB TRIM10 IGSF10 FCER1A MED12L	1.44e-06	196	181	8	05b437af66cb43ba098ea93a02dc2f7430bf8c1b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BIN1 TNFSF18 TUBB8 FOLR2 ITPR2 IGSF10 EIF4E NLRP4	1.50e-06	197	181	8	b597c292fc1cb381a4325fed15a32966c38def28
ToppCell	LPS-antiTNF-Myeloid-Myeloid_granulocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANPEP AGPAT4 GPR141 PTGS2 DHX8 DOCK5 CNTN1	2.00e-06	143	181	7	4a0f26eef935fe68a1da5d319503059a8a8682dd
ToppCell	LPS-antiTNF-Myeloid-Myeloid_granulocytic-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANPEP AGPAT4 GPR141 PTGS2 DHX8 DOCK5 CNTN1	2.00e-06	143	181	7	65328a0a2f3972fac596e07933e74b2ef7cceb84
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	USP34 SMG1 OSBPL3 TNFAIP3 OGA KDM6A UTY	9.46e-06	181	181	7	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	RASA3 ACTN1 RFX2 PRAG1 SVIL PAM KDM6A	1.05e-05	184	181	7	d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ERBB4 CFAP251 DNAH10 C1orf87 ANKDD1B CCDC180 TCTN2	1.09e-05	185	181	7	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	DMXL2 AHCTF1 ITPR2 SLFN12L OSBPL3 USPL1 UTY	1.13e-05	186	181	7	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP18 MEIOB RFX2 ITPR2 TGFBR2 TNFAIP3 BBOX1	1.25e-05	189	181	7	1cfc1fe27c4b57b4e52700fa8f679ce172cee5a9
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SPTB ATP8B1 LRRTM3 ACTN1 TTLL7 C1QTNF1 DMD	1.30e-05	190	181	7	d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCell	Control-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	DPP4 GRAMD1B MED12L SMARCA2 TNFAIP3 PRORP PHTF1	1.53e-05	195	181	7	6687e579582d7a239bee80846de0cf827a6f6a62
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP251 DNAH10 C1orf87 RFX2 RFX3 CCDC180 TCTN2	1.53e-05	195	181	7	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP251 DNAH10 C1orf87 RFX2 RFX3 CCDC180 TCTN2	1.53e-05	195	181	7	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	COPD-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	DPP4 GRAMD1B TGFBR2 SMARCA2 TNFAIP3 PRORP PHTF1	1.59e-05	196	181	7	c9bdd505c3ab380ed7b272aa518df31a0a706a06
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP251 DNAH10 C1orf87 RFX3 OSBPL3 DMD CCDC180	1.64e-05	197	181	7	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	AT2_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	DPP4 LRRK2 CHI3L2 LGI3 HABP2 HAS3 BBOX1	1.64e-05	197	181	7	8b5d4e1c33a57c899c51feb9a6f347232f8910a3
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 USP34 ERBB4 ITPR2 DMD KDM6A UTY	1.75e-05	199	181	7	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	RASA3 TDO2 CDK14 IGSF10 TENM3 LRP6 C1QTNF1	1.75e-05	199	181	7	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	Control-Control-Myeloid-Neutrophil\|Control / Disease, condition lineage and cell class	ANPEP AHCTF1 LRRK2 ACTN1 PTGS2 DOCK5 PLA2R1	1.81e-05	200	181	7	95c41f147a1594d49e73cb56d86d301c3115ce20
ToppCell	Sepsis-Int-URO-Myeloid-tDC\|Int-URO / Disease, condition lineage and cell class	CFAP251 CNTROB TBCCD1 IGSF10 FCER1A MED12L TCTN2	1.81e-05	200	181	7	f5d0497a72da21cad24e0ef51c3dc4d024dbf294
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Tgfb1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	EPOR ACOT1 PTER PTGS2 SPTBN5 TENM3	2.85e-05	145	181	6	84d50a13b48d50c16e768422908e371a55972d0e
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5A LRRK2 AGPAT4 GPR141 BRWD3 FOXRED2	3.33e-05	149	181	6	48fca6ae33d7722c024b43ce04f4dbce7b6b424b
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5A LRRK2 AGPAT4 GPR141 BRWD3 FOXRED2	3.72e-05	152	181	6	7e686721b95c837f2b0d5116927c8ecacef055ee
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNFSF18 LRRK2 AGPAT4 GPR141 CDK14 BMX	4.62e-05	158	181	6	91d265e95156f16459924d3e4dd11c180e164eee
ToppCell	Control-Myeloid-Monocytes,_Macrophages-Mast-cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPR141 TTLL12 DOCK5 FCER1A CACNA1I C1QTNF1	4.78e-05	159	181	6	81782e9e370558d61af5e0c760ac9759d69fb725
ToppCell	droplet-Liver-Hepatocytes-24m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACHE SPTA1 SPTB PAQR8 TRIM10 FCER1A	4.95e-05	160	181	6	9f24ee4fe1ba4590dce5dd4d43707fb007dca82f
ToppCell	droplet-Liver-Hepatocytes-24m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACHE SPTA1 SPTB PAQR8 TRIM10 FCER1A	4.95e-05	160	181	6	3b3b99305558f5b49d050fb9b249007630ea9085
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	USP34 SMG1 SMARCA2 TNFAIP3 KDM6A UTY	5.31e-05	162	181	6	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	11.5-Distal-RBC\|Distal / Age, Tissue, Lineage and Cell class	ACHE TUBB8 SPTA1 SPTB MEIOB GRAMD1B	5.49e-05	163	181	6	e9d814952d824539ff1dea119e4fca14a8c335a8
ToppCell	11.5-Distal-RBC-RBC\|Distal / Age, Tissue, Lineage and Cell class	ACHE TUBB8 SPTA1 SPTB MEIOB GRAMD1B	5.49e-05	163	181	6	31b60e065bac4ad380247964e7574f210106ebae
ToppCell	severe-HSPC\|severe / disease stage, cell group and cell class	CDC42BPA ZSWIM3 IGSF10 FCER1A MED12L PHTF1	5.88e-05	165	181	6	acd837d88ad3786c263f74651a6c0e02fa2fa2c5
ToppCell	Int-URO-Myeloid-tDC\|Int-URO / Disease, Lineage and Cell Type	CFAP251 CNTROB TBCCD1 IGSF10 MED12L TCTN2	5.88e-05	165	181	6	9803c3db6cdcf925bea7d9c382bf4fd05acf3509
ToppCell	facs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR ACHE SPTA1 SPTB RFX2 TRIM10	6.49e-05	168	181	6	17fb9426eeea407b26fb895b8397faca95b7552d
ToppCell	facs-Aorta-Heart-24m-Endothelial-endocardial_endothelial_cells\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MR1 TDO2 STAB1 BMX COQ8A PLD2	6.49e-05	168	181	6	edbab94f14e16a1a76546a18fe777a183080d1de
ToppCell	healthy_donor-Myeloid-Monocytic-Neutrophil\|healthy_donor / Disease condition, Lineage, Cell class and subclass	ANPEP LRRK2 ACTN1 PTGS2 DOCK5 BMX	6.49e-05	168	181	6	04259f5a9b067cd1b5619e34591e4b2fccc18535
ToppCell	facs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR ACHE SPTA1 SPTB RFX2 TRIM10	6.49e-05	168	181	6	a61b39884851384cffd430079040546d125b2b40
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	DOCK1 DPP4 ACHE IGSF10 FCER1A MED12L	6.49e-05	168	181	6	968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 LRRK2 ACTN1 DOCK5 BMX SVIL	7.16e-05	171	181	6	ab21f20ec041cbaacccbd7da4dccdb77ec8bc5c6
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 LRRK2 ACTN1 DOCK5 BMX SVIL	7.16e-05	171	181	6	97ad2cfff568a9d006ab1d2e6e00946ee4e3beb3
ToppCell	T_cells-GNLY+GZMB+_T_cells\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	RASA3 USP28 AGPAT4 PTCH1 DOCK5 PPM1L	7.16e-05	171	181	6	04c811817cfec45af5f2891793106cc7ddb0300e
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DOK1 AGPAT4 METTL4 TENM3 TGDS PAM	8.13e-05	175	181	6	a5db428b078938627e61b7e944c1e0c1d61ac2da
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DOK1 AGPAT4 METTL4 TENM3 TGDS PAM	8.13e-05	175	181	6	8b498eea1ec1c1f27b171025c3d08adf3687bafc
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 MYO5A ZFC3H1 LGI3 MED12L OGA	8.13e-05	175	181	6	1ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCell	droplet-Fat-Mat-18m-Hematologic-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTGS2 GRAMD1B FOXRED2 FCER1A COQ8A TNFAIP3	8.39e-05	176	181	6	867936a20f73f638055c19c8d88834aa2cc657cf
ToppCell	Adult-Immune-enucleated_erythrocyte-D231\|Adult / Lineage, Cell type, age group and donor	LRRIQ3 SPTB MRPL44 TRPC5 MEIOB BMX	8.66e-05	177	181	6	15ee303fb6caea1fd645c3b777666196ce500a1c
ToppCell	(05)_Ciliated-(4)_1wkpi\|(05)_Ciliated / shred by cell type and Timepoint	USP34 DNAH10 C1orf87 ACOT1 IQCB1 PAM	9.50e-05	180	181	6	85fc9b164147b28545e2397d32302eea03ef6346
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLR2 IRS1 CDK14 ITPR2 IGSF10 PPM1L	9.79e-05	181	181	6	4e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLR2 IRS1 CDK14 ITPR2 IGSF10 PPM1L	9.79e-05	181	181	6	ad30c01290fb98adbd0caed301a584761212c977
ToppCell	HSPCs-Erythroblasts\|HSPCs / Lineage and Cell class	EPOR SPTA1 SPTB AGPAT4 TRIM10 TTLL12	9.79e-05	181	181	6	4ded490f190af7ace343acdf317edc7373484d08
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOLR2 IRS1 CDK14 ITPR2 IGSF10 PPM1L	9.79e-05	181	181	6	3a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCell	HSPCs-Erythroblasts\|World / Lineage and Cell class	EPOR SPTA1 SPTB TRIM10 TTLL12 KIF22	9.79e-05	181	181	6	ce26f1accc8f69b7bc4b929073e975c887566c6a
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP28 STAB1 ENAM BMX PIK3C2B SMARCA2	9.79e-05	181	181	6	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANPEP IRS1 ATP8B1 SLC25A25 HABP2 MYRF	1.01e-04	182	181	6	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-LMPP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	LRRIQ3 ZSWIM3 ZNF559 CHI3L2 CCDC112 GAN	1.01e-04	182	181	6	69b5cae6fe3bbb0fc60bd2f71b6cfa6cbb0b00ee
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANPEP IRS1 ATP8B1 SLC25A25 HABP2 MYRF	1.01e-04	182	181	6	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANPEP IRS1 ATP8B1 SLC25A25 HABP2 MYRF	1.01e-04	182	181	6	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-C1ql2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EPOR DBH TDO2 PTER RFX3	1.03e-04	114	181	5	f48fd7d378626eb7ef972ff1df87dd6149cb355c
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-hematologic\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CDC42BPA ACHE SPTA1 SPTB TRIM10 FCER1A	1.04e-04	183	181	6	1db466cf757813322db1cdcc0bf1d91c062fd9de
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_3\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	IRS1 LRRTM3 ACTN1 PTCH1 PRAG1 SLFN12L	1.04e-04	183	181	6	f4ea7113ce9099222743d9ff02388d3d8a9e987b
ToppCell	10x5'v1-week_17-19-Hematopoietic-erythroid\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	EPOR CDC42BPA ACHE SPTA1 SPTB TRIM10	1.07e-04	184	181	6	0efc757d9512d6a8fe8176e977a94e4494ed9778
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	MYO5A GPR141 LRRTM3 ADAMTSL3 ITPR2 TENM3	1.07e-04	184	181	6	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ERBB4 LRRK2 GALNT7 RFX2 BBOX1 CNTN1	1.07e-04	184	181	6	8fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPOR ACHE MEIOB ADAMTSL3 TTLL7 C1QTNF1	1.07e-04	184	181	6	4cb5f299dd7413e0be1ad7af817ee614b23a18ae
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPOR ACHE MEIOB ADAMTSL3 TTLL7 C1QTNF1	1.07e-04	184	181	6	39bb0eb55bdc2cea46e41c7f21d8c5883f14e6bd
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-myocytic\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCDHAC2 ACTN1 PTCH1 TTLL7 SVIL DMD	1.07e-04	184	181	6	5cfc19ffb9f074bdf0d81c86e212a708ec141631
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	DMXL2 AHCTF1 SLFN12L OSBPL3 USPL1 UTY	1.10e-04	185	181	6	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPOR ACHE SPTA1 TRIM10 MED12L ANKDD1B	1.17e-04	187	181	6	46e15419e80bd7180f3171a99d845b01bb635e53
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic-Megakaryocytic-Megakaryocyte\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPOR ACHE SPTA1 TRIM10 MED12L ANKDD1B	1.17e-04	187	181	6	0d17b07770e4c881a7ca53a5bd42471457d198fb
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic-Megakaryocytic\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPOR ACHE SPTA1 TRIM10 MED12L ANKDD1B	1.17e-04	187	181	6	69068480f6819a6c8560ecbb05deb156b4055e12
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPOR ACHE SPTA1 TRIM10 MED12L ANKDD1B	1.17e-04	187	181	6	9c8b932a15b8b50982cba4cf8db750e257eb9503
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DMXL2 MYO5A FOLR2 GRB2 STAB1 GRAMD1B	1.21e-04	188	181	6	3be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP4 LRRTM3 TTLL7 STAB1 PLA2R1 C1QTNF1	1.21e-04	188	181	6	0aa8747c2931b0c91f6d78bb2db8fd8ede6dd559
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PRAG1 PTGS2 DOCK5 PAM CATSPERB MYRF	1.21e-04	188	181	6	43a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCell	droplet-Marrow-BM-30m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR ATAD5 ACHE SPTA1 AGPAT4 TRIM10	1.21e-04	188	181	6	f1a9d8ea174a4bef0fae8188e3bd96b7ac1a39bb
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 TRPC5 GALNT7 MTMR6 TENM3 PAM	1.21e-04	188	181	6	8de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCell	facs-Skin-nan-18m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASA3 SLC25A25 RFX2 TGFBR2 TNFAIP3 BBOX1	1.24e-04	189	181	6	6c71e81373cb7822de23c193a6350b6df9f567bc
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KREMEN1 ANPEP LRRK2 PTGS2 DOCK5 BMX	1.24e-04	189	181	6	235c24eeab5139f5821fccd5c879d8787682f4ef
ToppCell	droplet-Marrow-nan-3m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR ATAD5 ACHE SPTA1 SPTB TRIM10	1.24e-04	189	181	6	8a38baee58a27c2fa3f4bd131ab9f15723ed9295
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP4 LRRTM3 TTLL7 STAB1 PLA2R1 C1QTNF1	1.28e-04	190	181	6	a08c5929b05a4969852e351a93c4e4deb4c8d5b6
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TPO SPTB LRRTM3 ADAMTSL3 C1QTNF1 DMD	1.28e-04	190	181	6	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	MS-CD8-antiviral_CD4\|MS / Condition, Cell_class and T cell subcluster	USP18 AHCTF1 PTER SLFN12L MTMR6 SMARCA2	1.28e-04	190	181	6	8c831c4560b8e70f92b4c15644fea39f7f7afcf2
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP4 LRRTM3 TTLL7 STAB1 PLA2R1 C1QTNF1	1.28e-04	190	181	6	25525fee1da8a808034d9c916159fd0b6b26bce8
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	ERBB4 LRRTM3 GRAMD1B SVIL PAM DMD	1.28e-04	190	181	6	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	18-Airway-Mesenchymal-Airway_Smooth_Muscle\|Airway / Age, Tissue, Lineage and Cell class	TNFSF18 IRS1 ACTN1 PTCH1 PRAG1 SLFN12L	1.31e-04	191	181	6	86ce98d2c90c196474b06869de888cf5d1eed196
ToppCell	droplet-Marrow-BM-30m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR ACHE SPTA1 AGPAT4 TRIM10 KIF22	1.31e-04	191	181	6	08be56a4055a73c920d345fd3b2052a5ccb675d8
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	ERBB4 USP28 LRRTM3 SVIL PAM DMD	1.31e-04	191	181	6	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	droplet-Spleen-SPLEEN-1m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR CDC42BPA FKBP9 MEIOB TTLL12 KIF22	1.35e-04	192	181	6	a94f47a664a3c9d1b0250269674453309ab4bf95
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BIN1 AGPAT4 TTLL7 PIK3C2B LGI3 MYRF	1.35e-04	192	181	6	3916de42b9a626b5679ca98057d6e69f146b2810
ToppCell	Ciliated-cil-3\|World / Class top	CFAP251 DNAH10 ACOT1 RFX2 LGALS3BP CCDC180	1.35e-04	192	181	6	4989ebb8812b8af1870599acd932849122c05a29
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	RASA3 ACTN1 RFX2 PRAG1 TENM3 SVIL	1.35e-04	192	181	6	8b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IRS1 ACTN1 PTCH1 TTLL7 SVIL DMD	1.39e-04	193	181	6	146e8c148478ab61b1c1dbaf1ee98a8cd4a0ff8a
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BIN1 AGPAT4 TTLL7 PIK3C2B LGI3 MYRF	1.39e-04	193	181	6	4274c95cedad2ae8c6693ad00deda2b1ba5b5682
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FKBP9 LRRTM3 ADAMTSL3 IGSF10 PLA2R1 C1QTNF1	1.39e-04	193	181	6	64edc1d6fb0fe117767d494cf4a5723bf8be2804
Drug	leflunomide	CYP1A2 DHX38 PTGS2 DHX8 CBLIF BMX TNFAIP3 HAS3	3.59e-07	85	179	8	CID000003899
Drug	clozapine; Up 200; 10uM; MCF7; HG-U133A	EPOR BIN1 FOLR2 MR1 PFKL CHI3L2 ITPR2 SIX6 GAN NUP93 KLHDC10	5.32e-07	199	179	11	416_UP
Drug	N-phenylphthalimide	DPP4 ANPEP PTCH1 IQCB1	7.48e-07	10	179	4	CID000068215
Drug	phenylhydrazine	EPOR SPTA1 SPTB DBH TDO2 PRDX6 SPTBN5	3.82e-06	82	179	7	CID000007516
Drug	Esculin Hydrate [531-75-9]; Down 200; 11.8uM; HL60; HT_HG-U133A	CYP1A2 DMXL2 RASA3 TRPC5 AGPAT3 AGPAT4 PTCH1 ITPR2 CBLIF FOXRED2	4.35e-06	200	179	10	3052_DN
Drug	Hcys	APPBP2 ANPEP MYO5A DBH TDO2 PRDX6 LGALS3BP PLA2R1 TGDS CACNA1I BBOX1	4.91e-06	250	179	11	CID000000594
Drug	Be-B	ERCC6 CBLIF PGBD3	2.60e-05	8	179	3	CID000445304
Drug	pure blue	ERCC6 PTGS2 PGBD3	2.60e-05	8	179	3	CID005388082
Drug	aspirin, USP; Down 200; 100uM; MCF7; HT_HG-U133A	USP34 EPOR ATP8B1 FOXRED2 ARIH2 PAFAH2 SMARCA2 PLD2 KLHDC10	2.60e-05	196	179	9	1629_DN
Drug	Stachydrine hydrochloride; Down 200; 22.2uM; PC3; HT_HG-U133A	CYP1A2 BIN1 SPTB ATP8B1 TTLL7 MTMR6 OSBPL3 PLD2 KLHDC10	2.60e-05	196	179	9	4469_DN
Drug	Sulfanilamide [63-74-1]; Down 200; 23.2uM; PC3; HT_HG-U133A	BIN1 ATAD5 SPTB MRPL44 SARM1 ATP8B1 MTMR6 LRP6 UTY	2.71e-05	197	179	9	4474_DN
Drug	nifedipine; Up 200; 10uM; MCF7; HG-U133A	BIN1 CDC42BPA RASA3 CDK14 ITPR2 STAB1 SIX6 FOXRED2 TNFAIP3	2.71e-05	197	179	9	335_UP
Drug	Dapsone [80-08-0]; Up 200; 16.2uM; MCF7; HT_HG-U133A	EPOR ERCC6 SFSWAP ATAD5 AGPAT3 PAFAH2 SMARCA2 LRP6 CNTN1	2.93e-05	199	179	9	1705_UP
Drug	SC-58125; Up 200; 10uM; MCF7; HG-U133A	EPOR BIN1 RASA3 FOLR2 TDO2 ANKZF1 FOXRED2 LRP6 UTY	2.93e-05	199	179	9	254_UP
Disease	Leiomyosarcoma, Epithelioid	USP18 PTGS2 DMD	2.18e-06	5	179	3	C0205815
Disease	Leiomyosarcoma, Myxoid	USP18 PTGS2 DMD	2.18e-06	5	179	3	C0205816
Disease	leiomyosarcoma	USP18 PTGS2 DMD	2.18e-06	5	179	3	C0023269
Disease	Muscular Dystrophy	ACHE FKTN DMD	1.20e-05	8	179	3	C0026850
Disease	esophagus squamous cell carcinoma (is_marker_for)	DPP4 ERBB4 PTCH1 TNFAIP3 KDM6A	8.92e-05	74	179	5	DOID:3748 (is_marker_for)
Disease	Kabuki syndrome (implicated_via_orthology)	KDM6A UTY	1.09e-04	3	179	2	DOID:0060473 (implicated_via_orthology)
Disease	Hereditary elliptocytosis	SPTA1 SPTB	2.18e-04	4	179	2	cv:C0013902
Disease	platelet component distribution width	CYP1A2 KREMEN1 RASA3 SPTA1 LRRK2 IRS1 RDH13 ACTN1 RFX2 DOCK5 SVIL ANKDD1B CATSPERB ALG12	2.22e-04	755	179	14	EFO_0007984
Disease	hereditary spherocytosis (is_implicated_in)	SPTA1 SPTB	3.62e-04	5	179	2	DOID:12971 (is_implicated_in)
Disease	Hereditary spherocytosis	SPTA1 SPTB	3.62e-04	5	179	2	cv:C0037889
Disease	Anemia, hereditary spherocytic hemolytic	SPTA1 SPTB	3.62e-04	5	179	2	C0221409
Disease	gastritis (implicated_via_orthology)	PTGS2 CBLIF	3.62e-04	5	179	2	DOID:4029 (implicated_via_orthology)
Disease	mean platelet volume	CFAP251 MYO5A DIS3L ATAD5 SPTA1 POLR2A LRRK2 PAQR8 IRS1 RDH13 ACTN1 RFX2 DOCK5 GRAMD1B SVIL CATSPERB	5.12e-04	1020	179	16	EFO_0004584
Disease	Elliptocytosis, Hereditary	SPTA1 SPTB	5.40e-04	6	179	2	C0013902
Disease	nischarin measurement	SARM1 NISCH	5.40e-04	6	179	2	EFO_0801841
Disease	growth/differentiation factor 5 measurement	ANPEP SARM1	5.40e-04	6	179	2	EFO_0020429
Disease	platelet measurement	CFAP251 LRRK2 PAQR8 RDH13 ACTN1 ANKZF1 SLFN12L MED12L	7.12e-04	315	179	8	EFO_0005036
Disease	Bone neoplasms	PTGS2 TGFBR2	1.00e-03	8	179	2	C0005967
Disease	Malignant Bone Neoplasm	PTGS2 TGFBR2	1.00e-03	8	179	2	C0279530
Disease	Hereditary spherocytosis	SPTA1 SPTB	1.00e-03	8	179	2	C0037889
Disease	alcohol use disorder (implicated_via_orthology)	ERBB4 DBH SMARCA2 SMARCC2 KDM6A UTY	1.26e-03	195	179	6	DOID:1574 (implicated_via_orthology)
Disease	opportunistic bacterial infectious disease (implicated_via_orthology)	SMARCA2 SMARCC2	1.28e-03	9	179	2	DOID:0050340 (implicated_via_orthology)
Disease	Growth Disorders	CYP1A2 ERCC6 ACHE	1.35e-03	36	179	3	C0018273
Disease	sex interaction measurement, Crohn's disease	USP34 LRRK2 PRORP	1.47e-03	37	179	3	EFO_0000384, EFO_0008343
Disease	cognitive function measurement, self reported educational attainment	DMXL2 ERBB4 PTCH1 STAB1 PAM CACNA1I OGA ANAPC4	1.53e-03	355	179	8	EFO_0004784, EFO_0008354
Disease	Asthma, Occupational	PTGS2 TENM3	1.59e-03	10	179	2	C0264423
Disease	theophylline measurement	CYP1A2 LRRK2	1.59e-03	10	179	2	EFO_0021180
Disease	myeloid white cell count	USP34 BIN1 CDC42BPA DNAH10 RASA3 CHI3L2 NCLN PRDX6 TTLL12 PLA2R1 SLFN12L MED12L TNFAIP3 PRORP	1.81e-03	937	179	14	EFO_0007988
Disease	Microphthalmos	ERCC6 MYRF	1.94e-03	11	179	2	C0026010
Disease	gastrin-releasing peptide measurement	SARM1 HABP2	1.94e-03	11	179	2	EFO_0022000
Disease	B-Cell Lymphomas	PTGS2 TNFAIP3	2.32e-03	12	179	2	C0079731
Disease	Ck-beta-8-1 measurement	MMP28 SLFN12L	2.32e-03	12	179	2	EFO_0008085
Disease	Malignant neoplasm of breast	EPOR ERBB4 ERCC6 ACHE FOLR2 C1orf87 ATP8B1 RFX2 PTGS2 FKTN NISCH PLD2 DMD KLHDC10 PGBD3	2.39e-03	1074	179	15	C0006142
Disease	household income	ERBB4 FASTKD5 PIK3C2B SMARCA2 CACNA1I C1QTNF1 OGA	2.65e-03	304	179	7	EFO_0009695
Disease	cholangiocarcinoma (biomarker_via_orthology)	EPOR TGFBR2	2.73e-03	13	179	2	DOID:4947 (biomarker_via_orthology)
Disease	esophageal cancer (is_implicated_in)	TGFBR2 TNFAIP3	2.73e-03	13	179	2	DOID:5041 (is_implicated_in)
Disease	Coffin-Siris syndrome	SMARCA2 SMARCC2	2.73e-03	13	179	2	C0265338
Disease	Gastrointestinal Stromal Sarcoma	PTCH1 TGFBR2 DMD	2.93e-03	47	179	3	C3179349
Disease	frontal fibrosing alopecia	EFCAB5 PAQR8 TGFBR2	3.11e-03	48	179	3	EFO_0009855
Disease	Gastrointestinal Stromal Tumors	PTCH1 TGFBR2 DMD	3.49e-03	50	179	3	C0238198
Disease	pulmonary fibrosis (biomarker_via_orthology)	PTGS2 TGFBR2 HABP2	3.49e-03	50	179	3	DOID:3770 (biomarker_via_orthology)
Disease	Duchenne muscular dystrophy, disease progression measurement	DOCK1 SLFN12L NUP93	3.49e-03	50	179	3	EFO_0008336, MONDO_0010679
Disease	schizophrenia (biomarker_via_orthology)	ERBB4 PTGS2	3.65e-03	15	179	2	DOID:5419 (biomarker_via_orthology)
Disease	lifestyle measurement, depressive symptom measurement	DOCK1 DIS3L GPR141 ATP8B1	3.89e-03	105	179	4	EFO_0007006, EFO_0010724
Disease	Alzheimer disease, educational attainment	DPP4 BIN1 PIK3C2B ARIH2 SMARCA2 OGA	4.09e-03	247	179	6	EFO_0011015, MONDO_0004975
Disease	Heschl's gyrus morphology measurement	METTL4 MED12L DISP2	4.12e-03	53	179	3	EFO_0005852
Disease	vision disorder	TPO CNTN1	4.15e-03	16	179	2	MONDO_0021084
Disease	coffee consumption, cups of coffee per day measurement	EFCAB5 CYP1A2	4.15e-03	16	179	2	EFO_0004330, EFO_0006782
Disease	phosphatidylcholine 38:6 measurement	AHCTF1 MYRF	4.15e-03	16	179	2	EFO_0010388
Disease	diabetic neuropathy (biomarker_via_orthology)	LRRK2 PTGS2	4.69e-03	17	179	2	DOID:9743 (biomarker_via_orthology)
Disease	reticulocyte count	USP34 DNAH10 MMP28 SPTA1 SPTB FKBP9 IRS1 ACTN1 TRIM10 DOCK5 SLFN12L SENP1 NISCH MYRF	4.78e-03	1045	179	14	EFO_0007986
Disease	sphingosine 1-phosphate measurement	DMD KDM6A	5.25e-03	18	179	2	EFO_0800185
Disease	Tourette syndrome, schizophrenia	DNAH10 CACNA1I	5.25e-03	18	179	2	EFO_0004895, MONDO_0005090
Disease	level of Phosphatidylcholine (16:0_22:5) in blood serum	AGPAT3 MYRF	5.25e-03	18	179	2	OBA_2045079
Disease	Malignant neoplasm of skin	ERBB4 PTCH1 PTGS2	5.56e-03	59	179	3	C0007114
Disease	Skin Neoplasms	ERBB4 PTCH1 PTGS2	5.56e-03	59	179	3	C0037286
Disease	Lung Neoplasms	DOK1 CYP1A2 USP18 ERCC6 PRDX6 TGFBR2	5.73e-03	265	179	6	C0024121
Disease	Malignant neoplasm of lung	DOK1 CYP1A2 USP18 ERCC6 PRDX6 TGFBR2	5.83e-03	266	179	6	C0242379
Disease	DiGeorge syndrome (implicated_via_orthology)	DOCK1 TGFBR2	5.85e-03	19	179	2	DOID:11198 (implicated_via_orthology)
Disease	cumulative dose response to bevacizumab	GRAMD1B TGFBR2	5.85e-03	19	179	2	EFO_0005944

Protein segments in the cluster

Peptide	Gene	Start	Entry
VHWKNQFDHYSKQDR	ACHE	596	P22303
LVGQDDHNWKSEFYA	ACOT1	321	Q86TX2
VYFSQSAANLDNAWK	ATAD5	1756	Q96QE3
QNKFLCYADTIHWQD	ERBB4	151	Q15303
ALKYWYENHNISITN	FCER1A	151	P12319
YKNVNIQNFHISWKD	ACTN1	161	P12814
AWDDYDHQNFVKVRN	CCDC112	166	Q8NEF3
QDEVQQHEKWYQKFL	CCDC112	201	Q8NEF3
QWYDFLQNSSHLKES	ANAPC4	496	Q9UJX5
WFQHDDSPSLNIVKY	CATSPERB	721	Q9H7T0
WEAYANLHTAVNEEK	BMX	146	P51813
NVYEAFEHWKRLLNL	AAR2	266	Q9Y312
LHQFYNEAKERNWQI	BRWD3	1036	Q6RI45
NYWVTDVALHQVFKL	PAM	591	P19021
EKVFEYHNVLSNWNR	APPBP2	531	Q92624
LFYFERWENHNKSLQ	ARIH2	366	O95376
NTIYLNLWDHLQEAV	ANPEP	511	P15144
DVSWIYPDQKENTHF	CHI3L2	141	Q15782
FQLYNWLEKEIAALH	DMXL2	2071	Q8TDJ6
QAWNKLSYVNHAEDL	CDK14	381	O94921
SHQWYQYKRQADDLL	DMD	1876	P11532
SHLFKYFQEVVQLWE	CCDC180	516	Q9P1Z9
QLFYNEVSHWLAAEL	DISP2	921	A7MBM2
TEWAQLLESQQKYHD	GRAMD1B	676	Q3KR37
NHNKIEQVDFSWNTY	ATP8B1	486	O43520
KWHYNEQSLHESLFG	ARMC12	271	Q5T9G4
SFNLQATHDLLYHWQ	ALG12	36	Q9BV10
HQDLGYQNEIKWQNF	C1orf87	366	Q8N0U7
GNIKFYDHTLSIVNW	CFAP251	521	Q8TBY9
AQHQLGEFKTWFQEY	NUP93	341	Q8N1F7
YANVKQWLQEIDRHA	RAB1C	96	Q92928
TVQYQNELHKFLIWD	RAB22A	46	Q9UL26
DLQKYHNRDTWFQLQ	RASA3	101	Q14644
LWFLQKTVQEHYQDF	CYP1A2	261	P05177
NNHSWLIIQADIYFA	INTS8	831	Q75QN2
LSHQEFWAQLKNLFF	GPR141	216	Q7Z602
IYTSNHIWKLFENFL	ITPR2	1441	Q14571
NYQGTKRWLEDNLDH	NCLN	281	Q969V3
LVLQNAWQLHKTYDE	ERCC6	961	P0DP91
HFVNAASWGNEDYIK	MEIOB	61	Q8N635
RKEGVTHQQWYLFND	PAN2	881	Q504Q3
KLNNLLLNDYWVHNE	nan	251	O00370
ETLYHKIFWANQNKD	MED12L	481	Q86YW9
LFELQFNLSLYWSHE	LGALS3BP	356	Q08380
FNLSLYWSHEALFQK	LGALS3BP	361	Q08380
NSHWQLSDANRDYKI	MTMR6	141	Q9Y217
LEYLWLNFNNISVIH	LRIT2	81	A6NDA9
EEFLQRLDFYQHSWL	MYG1	226	Q9HB07
DFWALYNHIQLSSNL	EIF4E	71	P06730
FHYNAFQWAIKAFQE	KDM6A	141	O15550
LNKIHAYNLETNAWE	KLHDC10	286	Q6PID8
IANWRNHQETLKYQF	KIF22	76	Q14807
GSFENNWNIYKLLAH	PFKL	376	P17858
LKALNAHWSADAVYQ	TPO	421	P07202
PHQNFADLEQRYWKS	KDM4E	111	B2RXH2
KFQNLRWLDLHSNYI	LRRC18	71	Q8N456
LYWADAKLNFIHKSN	LRP6	196	O75581
WALYSFNDGEEHQKI	LRRK2	1811	Q5S007
YILTHFKGFWNVVNN	PTGS2	76	P35354
LFWNETFQHPYNTLK	KREMEN1	56	Q96MU8
RWISDHEYLYKQENN	DPP4	61	P27487
ANLLIKHYEEQQAWN	NLRP4	56	Q96MN2
LDKDRQAWNGHYFIL	FOXRED2	151	Q8IWF2
AEQDSWYQALLQLHN	IRS1	101	P35568
KNLAWVDSDQLLYQH	MRPL37	371	Q9BZE1
WVVKFNSLNELVDYH	GRB2	121	P62993
HIDFDDLNWQTRKYN	RDH13	181	Q8NBN7
QKYGALVNNFAAWDH	NSUN4	71	Q96CB9
NLYWIQKNAYSHKEN	PTER	56	Q96BW5
FSKYLFHLIVWDQQI	PIK3C2B	676	O00750
LDAYAEHKLQFWAVT	GBA	256	P04062
QNAWLFYHLAQTSDL	PCDHAC2	616	Q9Y5I4
QEQAAWYHTLQILFF	PAQR8	241	Q8TEZ7
IWNSEDQVQIHTYFK	FKBP9	141	O95302
NIFFWNQSRNKHDYN	EFCAB5	1086	A4FU69
LYWNSHLLLQENYNM	HABP2	216	Q14520
FLNIFSSYLNLHWKD	FASTKD5	261	Q7L8L6
AENQFWHKPYSEIAE	IGSF10	1571	Q6WRI0
IAENVNHKTYWQFLS	CBLIF	376	P27352
GLYFFSLNVHTWNQK	C1QTNF1	191	Q9BXJ1
NFELQLWNNYFHLAV	DOCK1	1016	Q14185
LWNNYFHLAVAFLTQ	DOCK1	1021	Q14185
ASFELQLWNNYFHLA	DOCK5	1036	Q9H7D0
QLWNNYFHLAVAFLT	DOCK5	1041	Q9H7D0
LYWDLYEHAQQQLLK	DOK1	336	Q99704
FQNHQEQREHYKLDW	ANKZF1	81	Q9H8Y5
NLNEFKEWQYFKNLH	GALNT7	601	Q86SF2
KNYLDNFWPDLKAAH	DIS3L	186	Q8TF46
HDEFKRWIYLNDQNL	GAN	496	Q9H2C0
WVHHKYNFDNLGQAL	CACNA1I	1356	Q9P0X4
QIRYWAAHDKEEAAN	CNTN1	841	Q12860
YFADAWSDQKGQIHL	DBH	111	P09172
FYGHTWQVQDKIDAN	BBOX1	176	O75936
WSNFFYDPQQHKVAL	COQ8A	491	Q8NI60
QELHKDTSRLYNFNW	FOLR2	66	P14207
TAFALQYHLWKNEEG	FKTN	111	O75072
NQSWYLNENIKHFCT	HEPHL1	236	Q6MZM0
YAPNKNWEFEKQHVD	HEPHL1	746	Q6MZM0
NLHWDVLNYDKATDI	MARCHF11	316	A6NNE9
EQKLHQAACLIQAYW	IQCB1	291	Q15051
LFTTHKGNFQLWLYQ	EPOR	296	P19235
HYQLWDYDQVRESNL	C19orf54	296	Q5BKX5
RNSLLQQFLEDWYHQ	HAS3	291	O00219
QQFLEDWYHQKFLGS	HAS3	296	O00219
YFNRNIWDQATHLQK	ENAM	781	Q9NRM1
LIQGFWLIDHNDYES	AHCTF1	811	Q8WYP5
NKIAENNDLLWMDYH	BIN1	101	O00499
NNDLLWMDYHQKLVD	BIN1	106	O00499
WQYFVNKSANNLHIV	DNAH10	2916	Q8IVF4
YFHLISGANDDQLQW	MEP1B	476	Q16820
WLLDHLSFINKINYQ	METTL4	11	Q8N3J2
TWAQQEHQLKEHYQA	CNTROB	361	Q8N137
DHLTLLAVYNSWKNN	DHX8	1041	Q14562
NFIKAKYWSTNAHEI	OSBPL3	721	Q9H4L5
FLQKHLDLKEDYNQW	PAFAH2	356	Q99487
IKQAWEANQHELLYQ	MR1	161	Q95460
EANQHELLYQKNWLE	MR1	166	Q95460
FELVLQNAWQLHKTY	PGBD3	491	Q8N328
QQQLYIFKGSHFWEV	MMP28	336	Q9H239
DIATYEQNLQQWHLD	MRPS27	371	Q92552
DIQTLKNYHWLNDEV	SENP2	401	Q9HC62
NAFHWAIKAFQDVLY	UTY	141	O14607
SEKPNWDYHAEIQAF	MRPL44	61	Q9H9J2
KNDQRFEFLQPWHQY	SFSWAP	481	Q12872
YVANLTNLVWEHKQA	SMARCA2	536	P51531
QLAKHLWNGTFDYEN	SVIL	1621	O95425
LFIITHQAYELWFKQ	TDO2	71	P48775
FKGLNQLTWLYLDHN	LRRTM3	81	Q86VH5
VIWDNIHANDYDQKR	OGA	276	O60502
LNSHLQWLLDNYETA	RFX2	196	P48378
NSHLQWLLDNYETAE	RFX3	181	P48380
LDNSAWYQKQHLVDF	YARS2	171	Q9Y2Z4
WYQKQHLVDFLAAVG	YARS2	176	Q9Y2Z4
DILNQDAKNYHAWQH	FNTA	191	P49354
VEDHLAWSKDINAYN	PRDX6	76	P30041
HEKWFQDNYGDAIEN	SMG1	2036	Q96Q15
KLNEFEQWITHYQAA	SMG1	2556	Q96Q15
WEFKNHNVAVYSIQG	PPM1L	86	Q5SGD2
YVSHINWNEDKAAAI	PTCH1	381	Q13635
NHLNWLNDEIINFYM	SENP1	461	Q9P0U3
KLQALWLEAHYQEAE	SIX6	86	O95475
YWLITAFHAKGNLQE	TGFBR2	321	P37173
LHQDVNTAWNLYQEL	PRORP	256	O15091
NGDNKWITTLHYAFQ	CDC42BPA	131	Q5VT25
WITTLHYAFQDDNNL	CDC42BPA	136	Q5VT25
HAFLEQWGLINYQVD	SMARCC2	501	Q8TAQ2
TIWEKDLNSHICYQF	PLA2R1	231	Q13018
NFVNELLHSKFNWTE	PLA2R1	716	Q13018
NKHQALQEELAIYWS	SPTBN5	1666	Q9NRC6
DLAYHQLKANEWQRL	ANKDD1B	431	A6NHY2
KELLNFYAWQHRESK	RRP7A	236	Q9Y3A4
HQKIKNWEQSFEYNE	ZNF37A	136	P17032
KNAWLQHYAVNSADP	SLC25A25	361	Q6KCM7
YRENFHNWKNVEKAL	TGDS	331	O95455
IDYQKLHDAFFKWQT	SF3B2	566	Q13435
YRANNHFITWILDAD	USPL1	451	Q5W0Q7
YQKFHQDSWSSKELQ	UBTFL6	236	P0CB48
AQWLHKLYQEKDALQ	AGPAT3	271	Q9NRZ7
FELVQHEYKKWQENS	TNFAIP3	346	P21580
QNGNYFHIFVKSWSL	SLFN12L	116	Q6IEE8
VLQGHKTFLNDAYNW	PHTF1	631	Q9UMS5
LTFNGIKWSHEYQEA	SARM1	676	Q6SZW1
FNIQDKNSSYFADWL	TUBB8	331	Q3ZCM7
IFNSEHQVLKNNTYW	TNFSF18	151	Q9UNG2
LELYAEWKHVNEDSQ	POLR2A	196	P24928
EPLQDFWHQKNTDYN	NISCH	1201	Q9Y2I1
LEWNKNINTYTSFHD	KRT10-AS1	181	Q8N816
EANAHFSIFYQWLKS	STAB1	996	Q9NY15
WHLAFYNDGKNAEQV	TENM3	491	Q9P273
SDHLTYLNVYLQWKN	DHX38	1006	Q92620
KQYQDHLNTRWQAFQ	SPTB	926	P11277
FQQYLADLHEAETWI	SPTA1	901	P02549
ELKHYIQEDNWRFEQ	USP28	676	Q96RU2
ELHFNENNWSLFKLT	PRAG1	981	Q86YV5
WKFNQTYQLAHGTAE	TTLL12	171	Q14166
HDAIAQESKRYWQNL	ZC3H7A	671	Q8IWR0
VQHDAAQLYLKLWNL	USP41	136	Q3LFD5
SEDHQRAQFSYKWQN	TRIM10	326	Q9UDY6
FTWASYLAQHEKIHN	ZNF790	431	Q6PG37
AYKLCHNEWEVVQNS	ZSWIM3	506	Q96MP5
FKWNSDFINHQIIYA	ZNF165	301	P49910
KAVRLDSNNHLYWNA	TTC37	816	Q6PGP7
NSYQLIADHADIEWK	TRPC5	626	Q9UL62
VQHDAAQLYLKLWNL	USP18	136	Q9UMW8
EHDVYWKSFNQKSVL	ZNF286B	191	P0CG31
SAWLHKLYQEKDAFQ	AGPAT4	271	Q9NRZ5
ENKFYEWLINTGHRQ	TBCCD1	526	Q9NVR7
HNKQALLSFWYNVCA	USP34	2796	Q70CQ2
NYKNLVAVDWESHIN	ZNF559	46	Q9BR84
HNQFFWLGKDYSNLI	PLD2	501	O14939
YLQTNQHDKARAVWL	ZFC3H1	1646	O60293
VEEHYIFKWNNNTIS	TCTN2	381	Q96GX1
WFTEFLQANQHDVAK	TTLL7	276	Q6ZT98
MWNNKNDLYLDDDHI	ADAMTSL3	1036	P82987
LSHLQYLFIENNDIW	LGI3	111	Q8N145
WSHYNENIREGQKDF	LRRIQ3	16	A6PVS8
HIYAKLFNWIVDNVN	MYO5A	406	Q9Y4I1
HQQNKWATLYDANYK	MYRF	356	Q9Y2G1