Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF888 ZNF34 ZNF571 MAFB ZNF836 ZNF721 ZNF841 ZBTB39 ZNF664 ZNF354C	2.81e-05	1244	34	10	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF888 ZNF34 ZNF571 MAFB ZNF836 ZNF721 ZNF841 ZBTB39 ZNF664 ZNF354C	3.38e-05	1271	34	10	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF888 ZNF34 ZNF571 MAFB ZNF836 ZNF721 ZNF841 ZBTB39 ZNF664 ZNF354C	8.25e-05	1412	34	10	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF888 ZNF34 ZNF571 MAFB ZNF836 ZNF721 ZNF841 ZBTB39 ZNF664 ZNF354C	1.09e-04	1459	34	10	GO:0000977
GeneOntologyMolecularFunction	phosphatidic acid binding	DEPTOR MARK1	7.59e-04	24	34	2	GO:0070300
GeneOntologyMolecularFunction	endonuclease activity	ZC3H12B APLF RNASE7	1.58e-03	136	34	3	GO:0004519
MousePheno	absent endolymphatic duct	FGF3 MAFB	4.36e-05	8	18	2	MP:0000041
Domain	zf-C2H2	ZNF34 ZNF571 ZNF836 ZNF721 ZNF841 ZBTB39 ZNF234 ZNF664 ZNF354C ZNF702P	1.98e-07	693	33	10	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF34 ZNF571 ZNF836 ZNF721 ZNF841 ZBTB39 ZNF234 ZNF664 ZNF354C ZNF702P	5.55e-07	775	33	10	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF34 ZNF571 ZNF836 ZNF721 ZNF841 ZBTB39 ZNF234 ZNF664 ZNF354C ZNF702P	5.68e-07	777	33	10	PS00028
Domain	Znf_C2H2	ZNF34 ZNF571 ZNF836 ZNF721 ZNF841 ZBTB39 ZNF234 ZNF664 ZNF354C ZNF702P	7.85e-07	805	33	10	IPR007087
Domain	ZnF_C2H2	ZNF34 ZNF571 ZNF836 ZNF721 ZNF841 ZBTB39 ZNF234 ZNF664 ZNF354C ZNF702P	8.12e-07	808	33	10	SM00355
Domain	-	ZNF34 ZNF571 ZNF836 ZNF721 ZNF841 ZBTB39 ZNF234 ZNF664 ZNF354C	1.85e-06	679	33	9	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF34 ZNF571 ZNF836 ZNF721 ZNF841 ZBTB39 ZNF234 ZNF664 ZNF354C	2.22e-06	694	33	9	IPR013087
Domain	Znf_C2H2-like	ZNF34 ZNF571 ZNF836 ZNF721 ZNF841 ZBTB39 ZNF234 ZNF664 ZNF354C	6.80e-06	796	33	9	IPR015880
Domain	zf-C2H2_6	ZNF571 ZNF836 ZNF721 ZNF841 ZNF234 ZNF354C	1.63e-05	314	33	6	PF13912
Domain	KRAB	ZNF34 ZNF571 ZNF836 ZNF234 ZNF354C	3.84e-04	358	33	5	PS50805
Domain	KRAB	ZNF34 ZNF571 ZNF836 ZNF234 ZNF354C	3.84e-04	358	33	5	PF01352
Domain	KRAB	ZNF34 ZNF571 ZNF836 ZNF234 ZNF354C	4.41e-04	369	33	5	SM00349
Domain	KRAB	ZNF34 ZNF571 ZNF836 ZNF234 ZNF354C	4.46e-04	370	33	5	IPR001909
Pubmed	The role of FGF-3 in early inner ear development: an analysis in normal and kreisler mutant mice.	FGF3 MAFB	9.84e-07	2	35	2	8631508
Pubmed	Requirements for FGF3 and FGF10 during inner ear formation.	FGF3 MAFB	1.47e-05	6	35	2	14623822
Pubmed	Retinoic acid rescues inner ear defects in Hoxa1 deficient mice.	FGF3 MAFB	2.74e-05	8	35	2	11528388
Pubmed	Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr).	FGF3 MAFB	2.74e-05	8	35	2	8100767
Pubmed	FGF8 initiates inner ear induction in chick and mouse.	FGF3 MAFB	3.53e-05	9	35	2	15741321
Pubmed	Development of the vertebrate ear: insights from knockouts and mutants.	FGF3 MAFB	4.40e-05	10	35	2	10354604
Pubmed	Requirement for downregulation of kreisler during late patterning of the hindbrain.	FGF3 MAFB	4.40e-05	10	35	2	11880356
Pubmed	Fgf3 and Fgf10 are required for mouse otic placode induction.	FGF3 MAFB	5.38e-05	11	35	2	12810586
Pubmed	Differential requirements for FGF3, FGF8 and FGF10 during inner ear development.	FGF3 MAFB	6.45e-05	12	35	2	17601531
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF721 ZNF354C	7.62e-05	13	35	2	19850934
Pubmed	Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain.	FGF3 MAFB	8.89e-05	14	35	2	18703040
Pubmed	Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium.	FGF3 MAFB	8.89e-05	14	35	2	17855431
Pubmed	Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest.	FGF3 MAFB	1.02e-04	15	35	2	11532923
Pubmed	Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling.	FGF3 MAFB	1.17e-04	16	35	2	15829521
Pubmed	Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea.	FGF3 MAFB	1.66e-04	19	35	2	34124068
Pubmed	Specification of the mammalian cochlea is dependent on Sonic hedgehog.	FGF3 MAFB	2.24e-04	22	35	2	12231626
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF34 ZNF721 ZNF841	8.03e-04	181	35	3	37372979
Pubmed	A GO catalogue of human DNA-binding transcription factors.	ZNF234 ZNF702P	8.26e-04	42	35	2	34673265
Cytoband	19q13.41	ZNF888 ZNF836 ZNF841 ZNF702P	3.88e-07	78	35	4	19q13.41
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF888 ZNF571 ZNF836 ZNF841 ZNF234 ZNF702P	2.58e-04	1192	35	6	chr19q13
Cytoband	11q13	BBS1 FGF3	3.69e-03	118	35	2	11q13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF888 ZNF34 ZNF571 ZNF836 ZNF721 ZNF841 ZBTB39 ZNF234 ZNF664 ZNF354C	1.08e-08	718	24	10	28
ToppCell	droplet-Marrow-BM-30m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCTD7 BBS1 KIAA1958 MCUB	7.77e-06	162	35	4	75df7ff779a3b9159ba97d852da1f8df650b9ce5
Disease	manic episode measurement, depressive episode measurement	DEPTOR RNLS	3.83e-05	9	31	2	EFO_0007704, EFO_0007705
Disease	Cleft upper lip	FGF3 MAFB	7.73e-04	39	31	2	C0008924
Disease	apolipoprotein B measurement	BBS1 MAFB ZNF664 GCNT4	4.91e-03	663	31	4	EFO_0004615
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement	MAFB MCUB	5.55e-03	106	31	2	EFO_0008317, EFO_0008596
Disease	neuritic plaque measurement	TLK1 RNLS CYP4F11	5.77e-03	349	31	3	EFO_0006798
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipid measurement	MAFB MCUB	5.86e-03	109	31	2	EFO_0004639, EFO_0008317, EFO_0008596
Disease	free cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	MAFB MCUB	5.97e-03	110	31	2	EFO_0008317, EFO_0008591, EFO_0008596
Disease	cholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	MAFB MCUB	5.97e-03	110	31	2	EFO_0008317, EFO_0008596, EFO_0010351
Disease	chylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement	MAFB MCUB	5.97e-03	110	31	2	EFO_0004574, EFO_0008317, EFO_0008596

Protein segments in the cluster

Peptide	Gene	Start	Entry
YRHQRIHTGEKPYQC	ZNF354C	456	Q86Y25
SCYRKNPQHKIEYRH	APLF	426	Q8IW19
QHYCHGLESKRLRKY	CDKL3	91	Q8IVW4
HVYLKSKARQCHPRF	OSMR	661	Q99650
YYCRRKCLKPRQHHR	FAM171A1	326	Q5VUB5
VCDKHLVNHYYCKRP	KCTD7	266	Q96MP8
RVKLCGNVKYYQSHH	MCUB	36	Q9NWR8
YAQSCRYKRVQQKHH	MAFB	251	Q9Y5Q3
RKLYCATKYHLQLHP	FGF3	46	P11487
YIIHRNAHRKNKPCT	CASD1	331	Q96PB1
QHNIYCIHYDRKAPD	GCNT4	156	Q9P109
LYHLAKHPEYQEQCR	CYP4F11	341	Q9HBI6
KDRRHHLKTYPNCFV	DEPTOR	51	Q8TB45
QYCHQKYIVHRDLKA	MARK1	171	Q9P0L2
NIYILRRDSKHPKYC	BBS1	271	Q8NFJ9
HPNCRYKEKRQNKSY	RNASE7	116	Q9H1E1
YHRAPRCIHVYKKNG	MRPL14	51	Q6P1L8
EKKENYHKHACREYR	TLK1	496	Q9UKI8
LDKKHRNHYRVYNLC	TPTE	271	P56180
KVFNQKRYLAYHHRC	ZNF702P	41	Q9H963
QYITCTPHYAKKHQR	RNLS	61	Q5VYX0
SNPVAHRKPKVYYNC	SLCO4C1	531	Q6ZQN7
YVHRRIHTGEKPYKC	ZNF721	561	Q8TF20
VRKRCHKHQVFDYPQ	EXT2	296	Q93063
HKCKYYHPERANQPQ	ZC3H12B	371	Q5HYM0
YHRRVHTGEKPYKCE	ZNF234	641	Q14588
NYHRRIHTGEKPYQC	ZBTB39	621	O15060
VYHQRNHTGEKPYKC	ZNF841	721	Q6ZN19
ARHYRRHTGEKPYKC	ZNF888	286	P0CJ79
HQRVHTGEKPYKCYE	ZNF664	161	Q8N3J9
YHQRIHSGEKPYECK	ZNF571	296	Q7Z3V5
YHQRNHTGEKPYKCI	ZNF836	851	Q6ZNA1
IYHQRIHTGEKPYKC	ZNF34	351	Q8IZ26
YRERCHQKVYHPITK	GOLGA8CP	446	A6NN73
KIYHEHSRGHKQCPY	KIAA1958	616	Q8N8K9
HSRGHKQCPYCLLYK	KIAA1958	621	Q8N8K9