Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionacetylcholine receptor regulator activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

2.58e-1127185GO:0030548
GeneOntologyMolecularFunctionneurotransmitter receptor regulator activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

3.15e-1128185GO:0099602
GeneOntologyMolecularFunctionprotein kinase binding

SPDYE2B SPDYE1 SPDYE21 SPDYE6 SPDYE18 SPDYE16 SPDYE2

6.21e-06873187GO:0019901
GeneOntologyMolecularFunctionkinase binding

SPDYE2B SPDYE1 SPDYE21 SPDYE6 SPDYE18 SPDYE16 SPDYE2

1.23e-05969187GO:0019900
GeneOntologyMolecularFunctionprotein folding chaperone

CALR APLF CLGN

3.68e-0573183GO:0044183
GeneOntologyMolecularFunctionsignaling receptor regulator activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

1.69e-04616185GO:0030545
GeneOntologyMolecularFunctiongated channel activity

CACNA1A CNGB1 PIEZO2

3.14e-03334183GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1A CNGB1 PIEZO2

3.39e-03343183GO:0005261
GeneOntologyMolecularFunctionmolecular carrier activity

CALR APLF

4.19e-03108182GO:0140104
GeneOntologyMolecularFunctionunfolded protein binding

CALR CLGN

5.66e-03126182GO:0051082
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1A CNGB1

5.92e-03129182GO:0005262
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1A CNGB1 PIEZO2

7.62e-03459183GO:0005216
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1A CNGB1

8.03e-03151182GO:0015085
GeneOntologyMolecularFunctionchannel activity

CACNA1A CNGB1 PIEZO2

1.10e-02525183GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1A CNGB1 PIEZO2

1.10e-02526183GO:0022803
GeneOntologyMolecularFunctionnuclear receptor binding

CALR PPARGC1B

1.21e-02187182GO:0016922
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

7.40e-1225165GO:0045737
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein kinase activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

1.37e-1128165GO:1904031
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

8.25e-0996165GO:0000079
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein kinase activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

1.01e-08100165GO:1904029
GeneOntologyBiologicalProcesspositive regulation of protein serine/threonine kinase activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

2.74e-07193165GO:0071902
GeneOntologyBiologicalProcesspositive regulation of cell cycle

SPDYE2B SPDYE1 CALR SPDYE6 SPDYE16 SPDYE2

3.85e-07407166GO:0045787
GeneOntologyBiologicalProcesspositive regulation of protein kinase activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

5.12e-06350165GO:0045860
GeneOntologyBiologicalProcessregulation of protein serine/threonine kinase activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

5.72e-06358165GO:0071900
GeneOntologyBiologicalProcesspositive regulation of kinase activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

1.04e-05405165GO:0033674
GeneOntologyBiologicalProcesspositive regulation of phosphorylation

SPDYE2B SPDYE1 PPARGC1B SPDYE6 SPDYE16 SPDYE2

1.66e-05780166GO:0042327
GeneOntologyBiologicalProcesspositive regulation of transferase activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

2.61e-05490165GO:0051347
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

SPDYE2B SPDYE1 PPARGC1B SPDYE6 SPDYE16 SPDYE2

3.26e-05879166GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

SPDYE2B SPDYE1 PPARGC1B SPDYE6 SPDYE16 SPDYE2

3.26e-05879166GO:0010562
GeneOntologyBiologicalProcessregulation of protein kinase activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

7.47e-05611165GO:0045859
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

SPDYE2B SPDYE1 PPARGC1B SPDYE6 SPDYE16 SPDYE2

7.86e-051028166GO:0043085
GeneOntologyBiologicalProcessregulation of kinase activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

1.29e-04686165GO:0043549
GeneOntologyBiologicalProcesspositive regulation of protein phosphorylation

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

1.66e-04724165GO:0001934
GeneOntologyBiologicalProcessregulation of phosphorylation

SPDYE2B SPDYE1 PPARGC1B SPDYE6 SPDYE16 SPDYE2

2.08e-041226166GO:0042325
GeneOntologyBiologicalProcessregulation of cell cycle

SPDYE2B SPDYE1 CALR SPDYE6 SPDYE16 SPDYE2

2.37e-041256166GO:0051726
GeneOntologyBiologicalProcessregulation of transferase activity

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

2.81e-04810165GO:0051338
GeneOntologyBiologicalProcessregulation of phosphate metabolic process

SPDYE2B SPDYE1 PPARGC1B SPDYE6 SPDYE16 SPDYE2

4.64e-041421166GO:0019220
GeneOntologyBiologicalProcessregulation of phosphorus metabolic process

SPDYE2B SPDYE1 PPARGC1B SPDYE6 SPDYE16 SPDYE2

4.68e-041423166GO:0051174
GeneOntologyBiologicalProcesspositive regulation of molecular function

SPDYE2B SPDYE1 PPARGC1B SPDYE6 SPDYE16 SPDYE2

4.80e-041430166GO:0044093
GeneOntologyBiologicalProcesspositive regulation of protein modification process

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

5.50e-04937165GO:0031401
GeneOntologyBiologicalProcessphotoreceptor cell maintenance

LCA5 CNGB1

5.98e-0447162GO:0045494
GeneOntologyBiologicalProcessprotein folding

CALR APLF CLGN

8.37e-04246163GO:0006457
GeneOntologyBiologicalProcessretina homeostasis

LCA5 CNGB1

1.11e-0364162GO:0001895
GeneOntologyBiologicalProcessregulation of protein phosphorylation

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

1.30e-031133165GO:0001932
GeneOntologyBiologicalProcessregulation of cytosolic calcium ion concentration

CACNA1A CNGB1

1.90e-0384162GO:0051480
GeneOntologyBiologicalProcessanatomical structure homeostasis

LCA5 CNGB1 PPARGC1B

2.02e-03334163GO:0060249
GeneOntologyBiologicalProcesstissue homeostasis

LCA5 CNGB1 PPARGC1B

2.02e-03334163GO:0001894
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

CACNA1A CNGB1 CALR

2.47e-03359163GO:0006874
GeneOntologyBiologicalProcessembryo implantation

CALR APLF

2.52e-0397162GO:0007566
GeneOntologyBiologicalProcesscalcium ion homeostasis

CACNA1A CNGB1 CALR

3.11e-03389163GO:0055074
GeneOntologyBiologicalProcessERAD pathway

CALR CLGN

3.76e-03119162GO:0036503
GeneOntologyBiologicalProcessmembrane depolarization

CACNA1A CNGB1

3.88e-03121162GO:0051899
GeneOntologyBiologicalProcesspositive regulation of protein metabolic process

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

3.96e-031458165GO:0051247
GeneOntologyBiologicalProcessregulation of protein modification process

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

4.33e-031488165GO:0031399
DomainSpy1

SPDYE2B SPDYE1 SPDYE21 SPDYE6 SPDYE16 SPDYE2

9.68e-1711176PF11357
DomainSpeedy

SPDYE2B SPDYE1 SPDYE21 SPDYE6 SPDYE16 SPDYE2

9.68e-1711176IPR020984
Domain-

CALR CLGN

2.34e-0631722.10.250.10
DomainCALRETICULIN_REPEAT

CALR CLGN

2.34e-063172PS00805
DomainCalret/calnex_CS

CALR CLGN

4.67e-064172IPR018124
DomainCalret/calnex

CALR CLGN

4.67e-064172IPR001580
DomainCALRETICULIN_1

CALR CLGN

4.67e-064172PS00803
DomainCALRETICULIN_2

CALR CLGN

4.67e-064172PS00804
DomainCalreticulin

CALR CLGN

4.67e-064172PF00262
DomainCalreticulin/calnexin_P_dom

CALR CLGN

7.79e-065172IPR009033
Domain-

CALR CLGN

3.31e-03951722.60.120.200
DomainIon_trans_dom

CACNA1A CNGB1

4.73e-03114172IPR005821
DomainIon_trans

CACNA1A CNGB1

4.73e-03114172PF00520
DomainRRM_1

SART3 PPARGC1B

1.50e-02208172PF00076
DomainRRM

SART3 PPARGC1B

1.63e-02217172SM00360
DomainConA-like_dom

CALR CLGN

1.66e-02219172IPR013320
DomainRRM_dom

SART3 PPARGC1B

1.77e-02227172IPR000504
DomainRRM

SART3 PPARGC1B

1.82e-02230172PS50102
Domain-

SART3 PPARGC1B

2.03e-022441723.30.70.330
DomainNucleotide-bd_a/b_plait

SART3 PPARGC1B

2.26e-02258172IPR012677
PathwayWP_BARDETBIEDL_SYNDROME

LCA5 CNGB1

1.05e-038882M45557
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1A CALR

2.90e-0314782MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1A CALR

3.06e-0315182M39329
PathwayWP_CILIOPATHIES

LCA5 CNGB1

4.51e-0318482M39880
PathwayREACTOME_ORGANELLE_BIOGENESIS_AND_MAINTENANCE

CNGB1 PPARGC1B

1.14e-0229782M27050
Pubmed

Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

2.54e-15918536272447
Pubmed

Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

2.59e-141318515611625
Pubmed

Characterization of a new family of cyclin-dependent kinase activators.

SPDYE2B SPDYE1 SPDYE6 SPDYE16 SPDYE2

1.25e-131718515574121
Pubmed

Evolution of the Cdk-activator Speedy/RINGO in vertebrates.

SPDYE6 SPDYE2

7.59e-07318222763696
Pubmed

Identification of chromosomes associated with dental caries susceptibility using quantitative trait locus analysis in mice.

CACNA1A CALR

3.79e-06618214767162
Pubmed

The DNA sequence of human chromosome 7.

SPDYE2B SPDYE21 SPDYE6 SPDYE16

6.78e-0544118412853948
Pubmed

Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice.

CACNA1A CALR

1.85e-043918224095980
Cytoband7q22.1

SPDYE2B SPDYE6 SPDYE2

1.15e-051131837q22.1
CytobandEnsembl 112 genes in cytogenetic band chr7q22

SPDYE2B SPDYE6 SPDYE2

8.29e-05219183chr7q22
CytobandEnsembl 112 genes in cytogenetic band chr7q11

SPDYE21 SPDYE18 SPDYE16

1.55e-04271183chr7q11
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE2B SPDYE1 SPDYE6 SPDYE2

1.40e-111294756
GeneFamilyRNA binding motif containing

SART3 PPARGC1B

4.71e-0321392725
ToppCellSmart-seq2|World / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SPDYE2B SPDYE6 SPDYE2

1.78e-051361731c831c25ae6fbf0888b8119e22e794c17c59f4d0
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)|Adult / Lineage, Cell type, age group and donor

CACNA1A SPDYE6 PIEZO2

3.78e-051751734db1a3c284488b3f6de7568363f176d74e2a4587
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231|Adult / Lineage, Cell type, age group and donor

CACNA1A SPDYE6 PIEZO2

3.78e-051751738d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCellMegakaryocytic-erythropoietic-Erythro-cells-Basophilic_Erythroblast|World / Lineage, cell class and subclass

LCA5 PIEZO2 CLGN

5.13e-05194173f054d78429364622d402ce1d9bf6ad13a1a1bf7e
ComputationalImmune response.

CACNA1A CLGN

7.92e-049752MODULE_169
Diseasesuntan

PPARGC1B PIEZO2

7.78e-04103122EFO_0004279
DiseaseParkinson's disease (implicated_via_orthology)

CALR PPARGC1B

1.79e-03157122DOID:14330 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
CEEEELEPWQKKVKE

ZNF280D

21

Q6N043
LEPWQKKVKEVEDDD

ZNF280D

26

Q6N043
KKEEEEDDRGEDGPK

CACNA1A

1201

O00555
EDSDWEPGKEDEEKE

APLF

481

Q8IW19
EEKEEDEEKGDWKPR

HIRIP3

246

Q9BW71
EKLEDEWEREELDKK

LCA5

406

Q86VQ0
DAKKPEDWDEEMDGE

CALR

246

P27797
EKRGADEDDEKEWGD

SART3

621

Q15020
EEEEKEEEEEWGRKR

PPARGC1B

441

Q86YN6
KREWSDESEEEPEKE

SPDYE2B

71

A6NHP3
EIEDPNDKKPEEWDE

CLGN

266

O14967
WEEVGEEAKKEAEEK

CNGB1

406

Q14028
KKEWSDESEEEPEKE

SPDYE16

31

A6NNV3
KKEWSDESEEEPEKE

SPDYE18

71

P0DV79
KKEWSDESEEEPEKE

SPDYE21

71

A0A494C086
KREWSDESEEEPEKE

SPDYE2

71

Q495Y8
KREWSDESEEEPEKE

SPDYE6

71

P0CI01
KREWSDESEEEPEKE

SPDYE1

31

Q8NFV5
VEWEDREDEPIKKKS

PIEZO2

1621

Q9H5I5
KKEWSDESEEEPEKE

nan

31

A6NJR5