Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	molybdopterin cofactor binding	XDH AOX1	3.96e-05	6	33	2	GO:0043546
GeneOntologyMolecularFunction	peptidase inhibitor activity	SPINT3 AMBP BIRC6 PI15	2.46e-04	187	33	4	GO:0030414
GeneOntologyMolecularFunction	flavin adenine dinucleotide binding	XDH NOS1 AOX1	4.98e-04	94	33	3	GO:0050660
GeneOntologyMolecularFunction	peptidase regulator activity	SPINT3 AMBP BIRC6 PI15	8.18e-04	257	33	4	GO:0061134
GeneOntologyMolecularFunction	cullin family protein binding	KLHL3 KLHL21	8.40e-04	26	33	2	GO:0097602
GeneOntologyMolecularFunction	Notch binding	CUL3 SNED1	9.06e-04	27	33	2	GO:0005112
GeneOntologyMolecularFunction	2 iron, 2 sulfur cluster binding	XDH AOX1	1.05e-03	29	33	2	GO:0051537
GeneOntologyMolecularFunction	FAD binding	XDH AOX1	2.40e-03	44	33	2	GO:0071949
GeneOntologyMolecularFunction	endopeptidase inhibitor activity	SPINT3 AMBP BIRC6	3.22e-03	180	33	3	GO:0004866
GeneOntologyMolecularFunction	calcium channel regulator activity	AMBP NOS1	3.59e-03	54	33	2	GO:0005246
GeneOntologyMolecularFunction	endopeptidase regulator activity	SPINT3 AMBP BIRC6	4.39e-03	201	33	3	GO:0061135
GeneOntologyMolecularFunction	enzyme inhibitor activity	SPINT3 AMBP BIRC6 PI15	5.51e-03	435	33	4	GO:0004857
GeneOntologyMolecularFunction	iron-sulfur cluster binding	XDH AOX1	7.35e-03	78	33	2	GO:0051536
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	CUL3 BIRC6 KLHL21 HACE1	7.39e-03	473	33	4	GO:0004842
GeneOntologyMolecularFunction	oxidoreductase activity	AMBP XDH WWOX NOS1 AOX1	7.98e-03	766	33	5	GO:0016491
GeneOntologyMolecularFunction	metal cluster binding	XDH AOX1	8.29e-03	83	33	2	GO:0051540
GeneOntologyCellularComponent	polar microtubule	CUL3 KLHL21	2.26e-05	5	32	2	GO:0005827
GeneOntologyCellularComponent	Cul3-RING ubiquitin ligase complex	CUL3 KLHL3 KLHL21	2.87e-05	39	32	3	GO:0031463
HumanPheno	Hyperchloremia	CUL3 KLHL3	3.60e-05	4	13	2	HP:0011423
HumanPheno	Pseudohypoaldosteronism	CUL3 KLHL3	8.97e-05	6	13	2	HP:0008242
MousePheno	metabolic acidosis	CUL3 KLHL3 NOS1	9.68e-07	12	24	3	MP:0012551
MousePheno	abnormal bicarbonate level	KLHL3 WWOX NOS1	2.98e-06	17	24	3	MP:0031394
MousePheno	abnormal bicarbonate homeostasis	KLHL3 WWOX NOS1	3.57e-06	18	24	3	MP:0031393
MousePheno	hyperkalemia	CUL3 KLHL3	8.47e-06	3	24	2	MP:0012339
MousePheno	acidosis	CUL3 KLHL3 NOS1	1.42e-05	28	24	3	MP:0003031
MousePheno	abnormal renal tubule morphology	PIKFYVE LRP2 KLHL3 XDH NOS1	3.57e-05	227	24	5	MP:0002703
MousePheno	abnormal pH regulation	CUL3 KLHL3 NOS1	4.89e-05	42	24	3	MP:0004043
MousePheno	increased circulating potassium level	CUL3 KLHL3 WWOX VWA8	4.96e-05	121	24	4	MP:0005627
MousePheno	abnormal cerebellum fissure morphology	LRP2 WWOX	1.01e-04	9	24	2	MP:0009267
MousePheno	abnormal urine homeostasis	LRP2 KLHL3 XDH GCK NOS1 SLC16A10	1.07e-04	466	24	6	MP:0009643
MousePheno	decreased circulating bicarbonate level	KLHL3 WWOX	1.26e-04	10	24	2	MP:0003017
MousePheno	abnormal hindbrain morphology	PIKFYVE CUL3 LRP2 SCUBE1 WWOX SLC9A6	1.34e-04	485	24	6	MP:0000841
MousePheno	abnormal circulating potassium level	CUL3 KLHL3 WWOX VWA8	1.90e-04	171	24	4	MP:0002668
MousePheno	increased urine pH	NOS1 SLC16A10	2.18e-04	13	24	2	MP:0009349
MousePheno	abnormal circulating bicarbonate level	KLHL3 WWOX	2.93e-04	15	24	2	MP:0003015
MousePheno	abnormal potassium level	CUL3 KLHL3 WWOX VWA8	3.20e-04	196	24	4	MP:0020887
MousePheno	abnormal potassium ion homeostasis	CUL3 KLHL3 WWOX VWA8	3.32e-04	198	24	4	MP:0011978
MousePheno	abnormal cerebellum morphology	PIKFYVE CUL3 LRP2 WWOX SLC9A6	4.47e-04	389	24	5	MP:0000849
MousePheno	increased circulating chloride level	CUL3 KLHL3 WWOX	5.90e-04	97	24	3	MP:0003019
MousePheno	abnormal metencephalon morphology	PIKFYVE CUL3 LRP2 WWOX SLC9A6	6.33e-04	420	24	5	MP:0000847
MousePheno	abnormal social/conspecific interaction behavior	AMBP CUL3 WWOX LPAR5 NOS1	6.40e-04	421	24	5	MP:0002557
MousePheno	abnormal nephron morphology	PIKFYVE LRP2 KLHL3 XDH NOS1	6.76e-04	426	24	5	MP:0003881
MousePheno	abnormal urine pH	NOS1 SLC16A10	8.27e-04	25	24	2	MP:0009348
MousePheno	lethality during fetal growth through weaning, complete penetrance	PIKFYVE CUL3 LRP2 XDH SCUBE1 GCK WWOX BIRC6	8.82e-04	1269	24	8	MP:0011111
MousePheno	increased circulating mineralocorticoid level	CUL3 KLHL3	8.95e-04	26	24	2	MP:0003373
MousePheno	increased circulating aldosterone level	CUL3 KLHL3	8.95e-04	26	24	2	MP:0002666
MousePheno	abnormal renal/urinary system physiology	LRP2 KLHL3 XDH GCK NOS1 SLC16A10	9.21e-04	695	24	6	MP:0005502
MousePheno	small cerebellum	CUL3 WWOX SLC9A6	1.07e-03	119	24	3	MP:0000852
Domain	2Fe-2S-bd	XDH AOX1	3.03e-06	2	33	2	IPR002888
Domain	FAD_binding_5	XDH AOX1	3.03e-06	2	33	2	PF00941
Domain	-	XDH AOX1	3.03e-06	2	33	2	3.30.365.10
Domain	Ald_Oxase/Xan_DH_a/b	XDH AOX1	3.03e-06	2	33	2	IPR000674
Domain	AldOxase/xan_DH_Mopterin-bd	XDH AOX1	3.03e-06	2	33	2	IPR008274
Domain	Ald_Xan_dh_C	XDH AOX1	3.03e-06	2	33	2	PF01315
Domain	Fer2_2	XDH AOX1	3.03e-06	2	33	2	PF01799
Domain	-	XDH AOX1	3.03e-06	2	33	2	3.90.1170.50
Domain	Ald_Xan_dh_C2	XDH AOX1	3.03e-06	2	33	2	PF02738
Domain	CO_deh_flav_C	XDH AOX1	3.03e-06	2	33	2	SM01092
Domain	CO_deh_flav_C	XDH AOX1	3.03e-06	2	33	2	PF03450
Domain	CO_DH_flav_C	XDH AOX1	3.03e-06	2	33	2	IPR005107
Domain	Ald_Oxase/xanthine_DH	XDH AOX1	3.03e-06	2	33	2	IPR016208
Domain	-	XDH AOX1	3.03e-06	2	33	2	1.10.150.120
Domain	Mopterin_DH_FAD-bd	XDH AOX1	3.03e-06	2	33	2	IPR002346
Domain	Ald_Xan_dh_C	XDH AOX1	3.03e-06	2	33	2	SM01008
Domain	EGF_3	LRP2 NTNG1 SNED1 SCUBE1 ADAM28 FBN3	3.10e-06	235	33	6	PS50026
Domain	EGF	LRP2 NTNG1 SNED1 SCUBE1 ADAM28 FBN3	3.10e-06	235	33	6	SM00181
Domain	EGF-like_dom	LRP2 NTNG1 SNED1 SCUBE1 ADAM28 FBN3	4.33e-06	249	33	6	IPR000742
Domain	EGF_1	LRP2 NTNG1 SNED1 SCUBE1 ADAM28 FBN3	4.97e-06	255	33	6	PS00022
Domain	EGF-like_CS	LRP2 NTNG1 SNED1 SCUBE1 ADAM28 FBN3	5.67e-06	261	33	6	IPR013032
Domain	EGF_2	LRP2 NTNG1 SNED1 SCUBE1 ADAM28 FBN3	6.19e-06	265	33	6	PS01186
Domain	MOLYBDOPTERIN_EUK	XDH AOX1	9.07e-06	3	33	2	PS00559
Domain	OxRdtase_Mopterin-bd_dom	XDH AOX1	9.07e-06	3	33	2	IPR000572
Domain	OxRdtase_Mopterin_BS	XDH AOX1	9.07e-06	3	33	2	IPR022407
Domain	cEGF	LRP2 SCUBE1 FBN3	1.27e-05	26	33	3	IPR026823
Domain	cEGF	LRP2 SCUBE1 FBN3	1.27e-05	26	33	3	PF12662
Domain	EGF_Ca-bd_CS	LRP2 SNED1 SCUBE1 FBN3	2.49e-05	97	33	4	IPR018097
Domain	EGF_CA	LRP2 SNED1 SCUBE1 FBN3	2.70e-05	99	33	4	PS01187
Domain	ASX_HYDROXYL	LRP2 SNED1 SCUBE1 FBN3	2.81e-05	100	33	4	PS00010
Domain	2Fe2S_fd_BS	XDH AOX1	3.02e-05	5	33	2	IPR006058
Domain	FAD-bd_2_sub1	XDH AOX1	3.02e-05	5	33	2	IPR016167
Domain	-	XDH AOX1	3.02e-05	5	33	2	3.30.43.10
Domain	2FE2S_FER_1	XDH AOX1	3.02e-05	5	33	2	PS00197
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP2 SNED1 SCUBE1 FBN3	3.53e-05	106	33	4	IPR000152
Domain	Fer2	XDH AOX1	4.52e-05	6	33	2	PF00111
Domain	2FE2S_FER_2	XDH AOX1	4.52e-05	6	33	2	PS51085
Domain	FAD_PCMH	XDH AOX1	4.52e-05	6	33	2	PS51387
Domain	CO_DH_flavot_FAD-bd_sub2	XDH AOX1	4.52e-05	6	33	2	IPR016169
Domain	FAD-bd_2	XDH AOX1	4.52e-05	6	33	2	IPR016166
Domain	-	XDH AOX1	4.52e-05	6	33	2	3.30.465.10
Domain	2Fe-2S_ferredoxin-type	XDH AOX1	4.52e-05	6	33	2	IPR001041
Domain	EGF_CA	LRP2 SNED1 SCUBE1 FBN3	6.12e-05	122	33	4	SM00179
Domain	EGF-like_Ca-bd_dom	LRP2 SNED1 SCUBE1 FBN3	6.52e-05	124	33	4	IPR001881
Domain	Beta-grasp_dom	XDH AOX1	2.72e-04	14	33	2	IPR012675
Domain	-	XDH AOX1	2.72e-04	14	33	2	3.10.20.30
Domain	ATPase_dyneun-rel_AAA	VWA8 DNAH9	2.72e-04	14	33	2	IPR011704
Domain	AAA_5	VWA8 DNAH9	2.72e-04	14	33	2	PF07728
Domain	-	SPINT3 AMBP	4.55e-04	18	33	2	4.10.410.10
Domain	Prtase_inh_Kunz-CS	SPINT3 AMBP	4.55e-04	18	33	2	IPR020901
Domain	KU	SPINT3 AMBP	4.55e-04	18	33	2	SM00131
Domain	EGF_CA	LRP2 SCUBE1 FBN3	4.65e-04	86	33	3	PF07645
Domain	BPTI_KUNITZ_2	SPINT3 AMBP	5.08e-04	19	33	2	PS50279
Domain	Kunitz_BPTI	SPINT3 AMBP	5.08e-04	19	33	2	PF00014
Domain	BPTI_KUNITZ_1	SPINT3 AMBP	5.08e-04	19	33	2	PS00280
Domain	Kunitz_BPTI	SPINT3 AMBP	7.48e-04	23	33	2	IPR002223
Domain	-	KLHL3 KLHL21	1.03e-03	27	33	2	2.130.10.80
Domain	hEGF	SNED1 FBN3	1.11e-03	28	33	2	PF12661
Domain	EGF	LRP2 SNED1 FBN3	1.41e-03	126	33	3	PF00008
Domain	Gal_Oxidase_b-propeller	KLHL3 KLHL21	1.64e-03	34	33	2	IPR015916
Domain	Growth_fac_rcpt_	LRP2 SCUBE1 FBN3	2.59e-03	156	33	3	IPR009030
Domain	BTB-kelch_protein	KLHL3 KLHL21	2.61e-03	43	33	2	IPR017096
Domain	Kelch	KLHL3 KLHL21	4.70e-03	58	33	2	SM00612
Domain	Gal_Oxase/kelch_b-propeller	KLHL3 KLHL21	4.86e-03	59	33	2	IPR011043
Domain	BACK	KLHL3 KLHL21	5.03e-03	60	33	2	SM00875
Domain	BACK	KLHL3 KLHL21	5.19e-03	61	33	2	PF07707
Domain	BACK	KLHL3 KLHL21	5.19e-03	61	33	2	IPR011705
Domain	Kelch_1	KLHL3 KLHL21	6.78e-03	70	33	2	PF01344
Domain	Kelch_1	KLHL3 KLHL21	6.78e-03	70	33	2	IPR006652
Pathway	WP_EFFECTS_OF_NITRIC_OXIDE	XDH NOS1 AOX1	3.90e-07	8	28	3	M39677
Pathway	WP_MOLYBDENUM_COFACTOR_MOCO_BIOSYNTHESIS	XDH AOX1	7.94e-05	7	28	2	M39799
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	CUL3 KLHL3 KLHL21 PSMB3 HACE1	2.73e-04	299	28	5	MM15711
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	CUL3 KLHL3 KLHL21 PSMB3 HACE1	3.13e-04	308	28	5	M1070
Pubmed	Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.	CUL3 KLHL3 KLHL21	1.40e-07	11	34	3	14528312
Pubmed	Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55.	CUL3 KLHL3	9.28e-07	2	34	2	30819806
Pubmed	Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo.	CUL3 KLHL3	9.28e-07	2	34	2	29869755
Pubmed	Crystal structure of KLHL3 in complex with Cullin3.	CUL3 KLHL3	9.28e-07	2	34	2	23573258
Pubmed	Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling.	XDH NOS1	9.28e-07	2	34	2	15486091
Pubmed	Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome).	CUL3 KLHL3	9.28e-07	2	34	2	24266877
Pubmed	Nitrite reductase activity of rat and human xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: evaluation of their contribution to NO formation in vivo.	XDH AOX1	9.28e-07	2	34	2	25537183
Pubmed	Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.	CUL3 KLHL3	9.28e-07	2	34	2	22266938
Pubmed	Polymorphism of genes involved in purine metabolism (XDH, AOX1, MOCOS) in kidney transplant recipients receiving azathioprine.	XDH AOX1	2.78e-06	3	34	2	22495427
Pubmed	Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension.	CUL3 KLHL3	2.78e-06	3	34	2	29897280
Pubmed	Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3.	CUL3 KLHL3	2.78e-06	3	34	2	25250572
Pubmed	Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice.	CUL3 KLHL3	2.78e-06	3	34	2	35064051
Pubmed	Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3KLHL21 protein complex during abscission.	CUL3 KLHL21	2.78e-06	3	34	2	28620047
Pubmed	Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease.	XDH AOX1	2.78e-06	3	34	2	19500084
Pubmed	Pseudohypoaldosteronism Type II	CUL3 KLHL3	5.56e-06	4	34	2	22073419
Pubmed	Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation.	CUL3 KLHL3	5.56e-06	4	34	2	26349538
Pubmed	Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.	CUL3 KLHL3	5.56e-06	4	34	2	23576762
Pubmed	Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis.	XDH NOS1	5.56e-06	4	34	2	27609225
Pubmed	Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.	CUL3 KLHL3	5.56e-06	4	34	2	23665031
Pubmed	Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.	CUL3 KLHL3	5.56e-06	4	34	2	23453970
Pubmed	Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms.	CUL3 KLHL3	9.26e-06	5	34	2	23962426
Pubmed	Cardiac nitric oxide synthase-1 localization within the cardiomyocyte is accompanied by the adaptor protein, CAPON.	XDH NOS1	9.26e-06	5	34	2	19800018
Pubmed	The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence.	LRP2 PKHD1L1	9.26e-06	5	34	2	20048263
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	CUL3 LRP2 WWOX BIRC6 AOX1	1.28e-05	313	34	5	20800603
Pubmed	Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors.	CUL3 KLHL3	1.94e-05	7	34	2	26100637
Pubmed	Arf4 is required for Mammalian development but dispensable for ciliary assembly.	LRP2 PKHD1L1	1.94e-05	7	34	2	24586199
Pubmed	Novel CUL3 Variant Causing Familial Hyperkalemic Hypertension Impairs Regulation and Function of Ubiquitin Ligase Activity.	CUL3 KLHL3 KLHL21	2.41e-05	57	34	3	34878901
Pubmed	The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.	CUL3 KLHL3	2.59e-05	8	34	2	23387299
Pubmed	KLHL2 interacts with and ubiquitinates WNK kinases.	CUL3 KLHL3	2.59e-05	8	34	2	23838290
Pubmed	Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.	CUL3 KLHL3	2.59e-05	8	34	2	26286618
Pubmed	Ubiquitylation-dependent localization of PLK1 in mitosis.	CUL3 KLHL21	3.33e-05	9	34	2	23455478
Pubmed	Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.	CUL3 KLHL21	3.33e-05	9	34	2	27387502
Pubmed	The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.	CUL3 KLHL21	6.08e-05	12	34	2	19995937
Pubmed	KEAP1 Mutations Drive Tumorigenesis by Suppressing SOX9 Ubiquitination and Degradation.	CUL3 KLHL3	6.08e-05	12	34	2	33173725
Pubmed	A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.	LRP2 NTNG1	7.19e-05	13	34	2	21079607
Pubmed	Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.	XDH NOS1	9.66e-05	15	34	2	19505917
Pubmed	MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.	NTNG1 NOS1	1.25e-04	17	34	2	27779093
Pubmed	A novel missense variant in CUL3 shows altered binding ability to BTB-adaptor proteins leading to diverse phenotypes of CUL3-related disorders.	CUL3 KLHL21	2.32e-04	23	34	2	33130828
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	AMBP LRP2	2.53e-04	24	34	2	31740596
Pubmed	Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.	CUL3 KLHL21	3.21e-04	27	34	2	30404837
Pubmed	Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling.	SNED1 SCUBE1	4.24e-04	31	34	2	36971701
Pubmed	Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing.	NTNG1 NOS1	4.52e-04	32	34	2	33288908
Pubmed	140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.	PIKFYVE BIRC6 NOS1	5.44e-04	163	34	3	16512683
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	LRP2 ZNF217 WWOX BIRC6	7.17e-04	418	34	4	34709266
Pubmed	Update on the Kelch-like (KLHL) gene family.	KLHL3 KLHL21	7.43e-04	41	34	2	23676014
Cytoband	Ensembl 112 genes in cytogenetic band chr12q24	NOS1 ZNF268 LINC00173	3.56e-03	415	34	3	chr12q24
GeneFamily	Kelch like\|BTB domain containing	KLHL3 KLHL21	1.41e-03	42	24	2	617
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL3 KLHL21	1.35e-02	134	24	2	861
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 WDR17 PKHD1L1 DNAH9 ADCY2	1.37e-07	160	34	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 WDR17 PKHD1L1 DNAH9 ADCY2	1.37e-07	160	34	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 PKHD1L1 DNAH9 ADAM28	8.16e-06	169	34	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMBP GCK DNAH9 ADCY2	1.00e-05	178	34	4	30ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTNG1 GCK DNAH9 ADCY2	1.14e-05	184	34	4	3da93e7d8b62463e307cc0425c47dbd3bef66799
ToppCell	Control-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	NTNG1 PKHD1L1 LINC00173 AOX1	1.17e-05	185	34	4	0af540323c0113203ba6c1a4cb32d2fb9cf79d39
ToppCell	mild-B_memory\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PIKFYVE NTNG1 PKHD1L1 ADAM28	1.55e-05	199	34	4	e6ac9a0959b0de2c6a99298feb7715aa80ade1dd
ToppCell	Biopsy_IPF-Mesenchymal-Mesothelial_cells\|Biopsy_IPF / Sample group, Lineage and Cell type	LRP2 NTNG1 PKHD1L1 AOX1	1.58e-05	200	34	4	553386523fd8f8f36617a0d81032224b7ddce442
ToppCell	COVID-19-Heart-Fib_+_CM\|Heart / Disease (COVID-19 only), tissue and cell type	NOS1 ADCY2 AOX1	6.81e-05	104	34	3	0b60a56a46f1fe3f8224ec6399d009a34a117a21
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	NTNG1 PKHD1L1 DNAH9	8.27e-05	111	34	3	1847dde68d349114286bc3317be6339666df4aa2
ToppCell	droplet-Fat-Gat-18m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WWOX ADCY2 AOX1	1.38e-04	132	34	3	4152529611eeacf0c547e2a134d5b98c45426b13
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPINT3 PIKFYVE ADAM28	1.48e-04	135	34	3	7743a01dc9c4542e910e7c0fe046004692a680bf
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SCUBE1 KLHL21 FBN3	1.51e-04	136	34	3	a2063abe2d7c3277bfbe1514c8c66363cf04b248
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SCUBE1 KLHL21 FBN3	1.54e-04	137	34	3	8e2fa2ef8becace96a68bb85c002329110902fbb
ToppCell	Control-Neu_1\|World / 5 Neutrophil clusters in COVID-19 patients	NOS1 LINC00173 ADAM28	1.58e-04	138	34	3	b7920c9a28d28220e7e4b30cd91ba13d0548eb76
ToppCell	facs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL3 DNAH9 ADAM28	1.68e-04	141	34	3	4aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCell	facs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL3 DNAH9 ADAM28	1.68e-04	141	34	3	e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRP2 LPAR5 ADCY2	1.79e-04	144	34	3	1b9e95e4f6e40042d3cf2f94c067f3a6b19428ea
ToppCell	COVID-19-kidney-Technical/muscle\|kidney / Disease (COVID-19 only), tissue and cell type	NOS1 DNAH9 ADCY2	1.94e-04	148	34	3	0dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCell	COVID-19-Heart-CM_5_(RYR2-)\|Heart / Disease (COVID-19 only), tissue and cell type	NOS1 ADCY2 SLC16A10	2.22e-04	155	34	3	d7e26696fd9c0a759524f331243db43059b33ed9
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Pro-B\|bone_marrow / Manually curated celltypes from each tissue	GCK LINC00173 AOX1	2.26e-04	156	34	3	b093dbba6662e4fffc8aa577587b77f64ac44b56
ToppCell	control-B_cell\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NTNG1 LPAR5 ADAM28	2.30e-04	157	34	3	1269b55f2ef6a493f6116b131cc5cc7b8897d63e
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue-9\|TCGA-Colorectal / Sample_Type by Project: Shred V9	WDR17 NOS1 ADCY2	2.39e-04	159	34	3	f376bf6cd0ed374211edac3c384f3a78f0caef2a
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH9 ADCY2 ADAM28	2.62e-04	164	34	3	e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTNG1 SEMA5B WDR17	2.67e-04	165	34	3	1b7dfa173e83aa8c46a3153a3261866c065c3b73
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTNG1 SEMA5B WDR17	2.67e-04	165	34	3	b4f7d33af7d053ec07b01bd67d861600a9c4822e
ToppCell	Control-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	NTNG1 PKHD1L1 AOX1	2.71e-04	166	34	3	32ebaefa6c074b28193fff764ee7c2c0e9357e20
ToppCell	normal-na-Lymphocytic_B-B_atypical-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	PIKFYVE WDR17 ADAM28	2.71e-04	166	34	3	30a180b67572c3f4fb3a291f271f855e1b20005e
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRP2 PKHD1L1 AOX1	2.86e-04	169	34	3	6937c46b119d4ce382fc8c2fa5925ede5ae89c81
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SNED1 SEMA5B PKHD1L1	2.86e-04	169	34	3	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SNED1 WDR17 DNAH9	2.86e-04	169	34	3	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRP2 PKHD1L1 AOX1	2.86e-04	169	34	3	0cece9b2bb1f58e465c20ec8735a4fc3c1021f03
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMBP ADCY2 AOX1	2.91e-04	170	34	3	02f0be0aab8ba2d35a83238609352ef3677511c9
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMBP WDR17 PI15	2.91e-04	170	34	3	ca88dc0b7a6960facb7c4d3c0f4795431a0a43d2
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMBP WDR17 PI15	2.91e-04	170	34	3	b6882665a27c78a63f3b4a2a8806c8438a98e407
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMBP WDR17 PI15	2.91e-04	170	34	3	626c12b9a51218f72ee32afb5fd5d4b075025d75
ToppCell	facs-Brain_Myeloid-Striatum-24m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMBP WDR17 PI15	2.91e-04	170	34	3	31daac8696ae8c021c0302d3b30dd8194054b3e7
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA5B WDR17 PI15	2.96e-04	171	34	3	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8\|TCGA-Liver / Sample_Type by Project: Shred V9	XDH SCUBE1 VWA8	2.96e-04	171	34	3	c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD8-Tem/emra_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	LRP2 DNAH9 ADCY2	2.96e-04	171	34	3	f28684ea0e74a22f4c140658496068e28a6d3605
ToppCell	ICU-SEP-Lymphocyte-B-B_intermediate\|ICU-SEP / Disease, Lineage and Cell Type	NTNG1 PKHD1L1 ADAM28	2.96e-04	171	34	3	2e44bf6f3d90193e7cadcac48bb852bd632a81bc
ToppCell	10x5'-Lung-Lymphocytic_B-Memory_B_cells\|Lung / Manually curated celltypes from each tissue	NTNG1 PKHD1L1 ADAM28	3.01e-04	172	34	3	2cb2dc7cfd6db5a98a393b1a84c23abf3d692a53
ToppCell	ASK454-Epithelial-Transformed_epithelium\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	PKHD1L1 ZNF268 SLC16A10	3.01e-04	172	34	3	3986f0f098ef5e096c8d9ee3d335b8404083701f
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMBP ADCY2 AOX1	3.06e-04	173	34	3	07798461d12d04f3dabff03481c999cb07c5af2f
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMBP ADCY2 AOX1	3.06e-04	173	34	3	f31e738c2b3b319fb40b0b16b2393a51c9a8999c
ToppCell	mild_COVID-19_(asymptomatic)-B_memory\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	NTNG1 SNED1 ADAM28	3.06e-04	173	34	3	9082ad77b44f65b72094df6e502cce81b62fe81a
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 PKHD1L1 DNAH9	3.06e-04	173	34	3	66f37c1437705734b20601656fa4aa1d92ca30be
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 PKHD1L1 DNAH9	3.06e-04	173	34	3	649b08a409095592cccf31883be69c754411280d
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	WDR17 PI15 AOX1	3.11e-04	174	34	3	778e0317c0c63fa4efd74114feb760975b819d92
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIKFYVE LPAR5 ADAM28	3.11e-04	174	34	3	ebe6ce173ad12d4a2afa39f8d6185c0e4f97fb1e
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 NOS1 DNAH9	3.17e-04	175	34	3	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 NOS1 DNAH9	3.22e-04	176	34	3	c6484334187f64cd00cd35e77d8ae436556b4260
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMBP ADCY2 AOX1	3.22e-04	176	34	3	2e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCell	mild_COVID-19_(asymptomatic)-B_memory\|World / disease group, cell group and cell class (v2)	NTNG1 SNED1 ADAM28	3.27e-04	177	34	3	057871e211c6508b2a679d391f3cf0ac7ccfc628
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRP2 PKHD1L1 AOX1	3.38e-04	179	34	3	056df2aaff750e0e283e7da78fcc3c90c366aac0
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRP2 PKHD1L1 AOX1	3.38e-04	179	34	3	f5f3945ef3b9efc5921a71fd51deeb2c80f0ce11
ToppCell	Severe-Lymphoid-B-\|Severe / Condition, Lineage, Cell class and cell subclass	PIKFYVE PKHD1L1 ADAM28	3.44e-04	180	34	3	fd3eb751704b14ff1500e4bd041441644d233e9c
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMBP PKHD1L1 ADCY2	3.44e-04	180	34	3	6b1606238417490e0d9930870a7827419d1c3737
ToppCell	Severe-Lymphoid-B\|Severe / Condition, Lineage, Cell class and cell subclass	PIKFYVE PKHD1L1 ADAM28	3.44e-04	180	34	3	67ffaf5096f025c3c61fffe52f6c8a96f120fc6f
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRP2 NTNG1 PKHD1L1	3.50e-04	181	34	3	65eaa9bc1022bcf0c5f0f92c07a2cbbf11f9b59c
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(PRG4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRP2 NTNG1 PKHD1L1	3.50e-04	181	34	3	eaac7d58117eddfff06b25521efc431c1351d592
ToppCell	10x5'-Liver-Lymphocytic_B-Memory_B_cells\|Liver / Manually curated celltypes from each tissue	NTNG1 PKHD1L1 ADAM28	3.50e-04	181	34	3	a9f4df288c34e3b2b6ed861ac6cda970c3ee08b1
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPINT3 LRP2 DNAH9	3.55e-04	182	34	3	587636c0f127231de21acd8aa632b74ff22ca8c2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPINT3 LRP2 DNAH9	3.55e-04	182	34	3	adfadd7893e74b3002f13f00875e3667d3493e0c
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIKFYVE LPAR5 ADAM28	3.55e-04	182	34	3	9c120ddd109103ef6fac9c32b84d16a7624d0580
ToppCell	10x5'-Lung-Lymphocytic_B\|Lung / Manually curated celltypes from each tissue	NTNG1 PKHD1L1 ADAM28	3.55e-04	182	34	3	310f94437d197eaaaf6e30e68063b33e94befe77
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GCK DNAH9 ADCY2	3.55e-04	182	34	3	398ce074a04f6482470b488f1affae4af7d2ec58
ToppCell	URO-Lymphocyte-B-B_memory\|URO / Disease, Lineage and Cell Type	NTNG1 PKHD1L1 ADAM28	3.55e-04	182	34	3	8ffdf15230349ad53fe15bb467724d28c5a05bf6
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRP2 PKHD1L1 AOX1	3.61e-04	183	34	3	c5caac6ed6c8d67f5c336281d9fd903976509445
ToppCell	Severe_COVID-19-B_cell-B_cell\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	PIKFYVE PKHD1L1 ADAM28	3.61e-04	183	34	3	5634e528001c389efd1e380f01ad40072f60e943
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTNG1 GCK ADCY2	3.61e-04	183	34	3	d26c7b79895de28961b8d68351f28d4bb531c75c
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRP2 PKHD1L1 AOX1	3.61e-04	183	34	3	9d5a363fbe6f0a1668c9d584df65ee1c283349c7
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 PKHD1L1 DNAH9	3.67e-04	184	34	3	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	Healthy/Control-B_memory\|World / Disease group and Cell class	NTNG1 PKHD1L1 ADAM28	3.67e-04	184	34	3	9e1879d86b535ede9b47deb0752e291f987a5d5e
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 PKHD1L1 DNAH9	3.67e-04	184	34	3	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Memory_B_cells\|bone_marrow / Manually curated celltypes from each tissue	NTNG1 PKHD1L1 ADAM28	3.67e-04	184	34	3	ffc9eec123de34a4f17ed27fe4f0a1b3cb84697f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 PKHD1L1 DNAH9	3.67e-04	184	34	3	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NTNG1 SEMA5B PI15	3.67e-04	184	34	3	4d4d8f3f44c67d74c57e7af7b7c158f0157b2f49
ToppCell	COPD-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	NTNG1 PKHD1L1 AOX1	3.73e-04	185	34	3	23579988036fc1925992c31919750f9b3fe9f790
ToppCell	COPD-Lymphoid-B\|World / Disease state, Lineage and Cell class	CUL3 SNED1 ADAM28	3.73e-04	185	34	3	22891ed75e25ef30dfa541cb82d85e08ce07e7d9
ToppCell	BL-critical-LOC-Lymphoid-B_cell\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NTNG1 PKHD1L1 ADAM28	3.79e-04	186	34	3	27d4c38b180e4ce2bf3e7c4ad3db3a2ffca05ca8
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA5B WDR17 PI15	3.79e-04	186	34	3	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRP2 ADCY2 AOX1	3.79e-04	186	34	3	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	Control-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	PIKFYVE SNED1 ADAM28	3.85e-04	187	34	3	4e64be635f445276e71f2937f33f041c3a4204ab
ToppCell	Healthy_donor-B_memory\|World / disease group, cell group and cell class (v2)	NTNG1 PKHD1L1 ADAM28	3.85e-04	187	34	3	4f68e3243071a4549c80aff8bff32c6ad892ee7f
ToppCell	lymphoid-B_cell-Naive_B_cell\|World / Lineage, cell class and subclass	PIKFYVE PKHD1L1 ADAM28	3.85e-04	187	34	3	904ffd8cf4513e86fcd4c2b7faf24a34fbd2dce3
ToppCell	IPF-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	PIKFYVE SNED1 ADAM28	3.85e-04	187	34	3	af1327559f7e01bec070881cae52834917c3da65
ToppCell	lymphoid-B_cell\|World / Lineage, cell class and subclass	PIKFYVE PKHD1L1 ADAM28	3.85e-04	187	34	3	2abbc01fd7f5b4e52113699625287893c991f8da
ToppCell	Control-Lymphoid_B-B_memory\|Control / Disease group, lineage and cell class	NTNG1 PKHD1L1 ADAM28	3.91e-04	188	34	3	ba4245de3bee29118abab57c4fce60b2007a189c
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_memory-B_memory-3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NTNG1 PKHD1L1 ADAM28	3.91e-04	188	34	3	cd833a125a5279ac32a9a9cb9ecd05ae24bea3a9
ToppCell	Healthy/Control-B_memory\|Healthy/Control / Disease group and Cell class	NTNG1 PKHD1L1 ADAM28	3.91e-04	188	34	3	3aff07f77b2b15e7a30e47b30115178abe64474e
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_memory\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NTNG1 PKHD1L1 ADAM28	3.91e-04	188	34	3	9256c5f45c97df209bb9c322c3b557d4f726a333
ToppCell	COVID-19-lung-Vein_EC\|lung / Disease (COVID-19 only), tissue and cell type	KLHL3 PKHD1L1 NOS1	3.91e-04	188	34	3	d582b76fc2faac526c9bf97503041129e1a6a211
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRP2 NTNG1 AOX1	3.91e-04	188	34	3	e82104f71bcdab7392fdb076dc3560255964fd9e
ToppCell	COPD-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	NTNG1 PKHD1L1 AOX1	3.91e-04	188	34	3	159d63ecc3653a7449fc6acefd6ef0464845260e
ToppCell	COPD-Epithelial-Mesothelial\|COPD / Disease state, Lineage and Cell class	NTNG1 PKHD1L1 AOX1	3.97e-04	189	34	3	79bb2593ad5d17f94b17972884241f03a0f43770
ToppCell	CTRL-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	PIKFYVE SNED1 ADAM28	3.97e-04	189	34	3	14f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NTNG1 SNED1 AOX1	3.97e-04	189	34	3	a153b83314cf52808f685296cff8c95af3f4983d
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_memory-B_memory-3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NTNG1 PKHD1L1 ADAM28	3.97e-04	189	34	3	ac0203f17b481d608587113ea2de0f383b29ed27
ToppCell	CF-Lymphoid-B_cell\|CF / Disease state, Lineage and Cell class	PIKFYVE SNED1 ADAM28	4.03e-04	190	34	3	374d8fd63c733178acab07682ed1519693efab45
Drug	urothione	AMBP XDH WWOX AOX1	8.65e-10	10	34	4	CID000086845
Drug	SR4330	AMBP WWOX AOX1	2.54e-07	9	34	3	CID000088336
Drug	AC1Q1UX1	XDH GCK WWOX AOX1	2.64e-07	37	34	4	CID000165917
Drug	nimorazole	XDH WWOX AOX1	4.98e-07	11	34	3	CID000023009
Drug	tungstate	XDH GCK WWOX ADCY2 AOX1	5.46e-07	108	34	5	CID000001152
Drug	pterin	AMBP XDH WWOX NOS1 AOX1	5.46e-07	108	34	5	CID000073000
Drug	NSC-13158	AMBP WWOX AOX1	8.61e-07	13	34	3	CID000079470
Drug	isoxanthopterin	AMBP XDH AOX1	1.10e-06	14	34	3	CID000010729
Drug	5-hydroxypyrazinoic acid	XDH AOX1	2.16e-06	2	34	2	CID000161825
Drug	5-hydroxypyrazinamide	XDH AOX1	2.16e-06	2	34	2	CID000151823
Drug	2-hydroxypurine	XDH AOX1	6.49e-06	3	34	2	CID000075323
Drug	AC1L212F	XDH AOX1	1.30e-05	4	34	2	CID000013118
Drug	picrolonic acid	XDH AOX1	1.30e-05	4	34	2	CID000068369
Drug	AC1L3UXH	XDH AOX1	1.30e-05	4	34	2	CID000065446
Drug	1 Tc1	XDH WWOX NOS1 AOX1	1.47e-05	100	34	4	CID000083786
Drug	NSC344479	XDH WWOX AOX1	1.76e-05	34	34	3	CID000023850
Drug	quinonoid dihydro-(6H)-biopterin	XDH WWOX NOS1	1.76e-05	34	34	3	CID000000252
Drug	N-methylnicotinamide	XDH WWOX AOX1	1.76e-05	34	34	3	CID000064950
Drug	pyrimidin-4-one	XDH AOX1	2.16e-05	5	34	2	CID000020695
Drug	4-methylquinoline	WWOX AOX1	2.16e-05	5	34	2	CID000010285
Drug	phosphoglycocyamine	AMBP WWOX	3.23e-05	6	34	2	CID000188984
Drug	nicotinamide N-oxide	AMBP AOX1	3.23e-05	6	34	2	CID000072661
Drug	BOF-4272	XDH AOX1	3.23e-05	6	34	2	CID000121917
Drug	MEcPP	AMBP WWOX	4.52e-05	7	34	2	CID000160264
Drug	6-mercapto-FAD	XDH WWOX	4.52e-05	7	34	2	CID003035860
Drug	isovanillic acid	WWOX AOX1	4.52e-05	7	34	2	CID000012575
Drug	HMMF	AMBP WWOX	4.52e-05	7	34	2	CID000107853
Drug	Furaltadone hydrochloride	XDH AOX1	6.03e-05	8	34	2	CID000003434
Drug	1-methyl-4-phenylpyridinium	ZMAT3 WWOX NOS1 AOX1	6.14e-05	144	34	4	CID000039484
Drug	benzamidine	AMBP LRP2 XDH AOX1	6.65e-05	147	34	4	CID000002332
Drug	2,4-dimethylaniline	AMBP AOX1	7.74e-05	9	34	2	CID000007250
Drug	3-hydroxy-3-methyloxindole	WWOX AOX1	7.74e-05	9	34	2	CID000151066
Drug	N-methyl-2-pyridone-5-carboxamide	AMBP AOX1	9.67e-05	10	34	2	CID000069698
Drug	1-methyluracil	XDH WWOX	9.67e-05	10	34	2	CID000012009
Drug	Y-S-H	AMBP XDH	9.67e-05	10	34	2	CID000449035
Drug	rhodoquinone	WWOX BIRC6	9.67e-05	10	34	2	CID006441300
Drug	benzaldehyde	XDH WWOX AOX1	9.82e-05	60	34	3	CID000000240
Drug	aminotriazole	LRP2 XDH WWOX NOS1	1.09e-04	167	34	4	CID000001639
Drug	bicarbonate	XDH BIRC6 ADCY2 SLC9A6 SLC16A10	1.14e-04	325	34	5	CID000000767
Drug	AC1L1EJT	LRP2 XDH AOX1	1.19e-04	64	34	3	CID000002823
Drug	riboflavin 5'-phosphate	XDH WWOX NOS1 AOX1	1.19e-04	171	34	4	CID000000710
Drug	nitrate	AMBP XDH WWOX BIRC6 NOS1	1.24e-04	331	34	5	CID000000943
Drug	mercuric bromide	AMBP CUL3 ZMAT3 PI15 ADCY2 KLHL21 ADAM28 AOX1	1.47e-04	1076	34	8	ctd:C042720
Drug	pteridine	XDH WWOX NOS1	1.62e-04	71	34	3	CID000001043
Drug	AC1L9AGE	GCK WWOX	1.67e-04	13	34	2	CID000441043
Drug	ferric ammonium sulfate	XDH WWOX	1.67e-04	13	34	2	CID000186086
Drug	3-aminopyridine adenine dinucleotide	XDH WWOX	1.67e-04	13	34	2	CID003080722
Drug	oxypurinol	XDH NOS1 AOX1	1.69e-04	72	34	3	CID000004644
Drug	flavin adenine dinucleotide sodium	XDH GCK WWOX NOS1 AOX1	1.74e-04	356	34	5	CID000000703
Drug	AC1L4O4H	XDH WWOX	1.95e-04	14	34	2	CID000189136
Drug	ronidazole	XDH AOX1	1.95e-04	14	34	2	CID000005094
Drug	AC1L9T0X	NOS1 AOX1	1.95e-04	14	34	2	CID000500472
Drug	AC1L8RPK	XDH WWOX	1.95e-04	14	34	2	CID000407011
Drug	ethanol	PIKFYVE XDH GCK BIRC6 NOS1 ADCY2 AOX1	2.00e-04	837	34	7	CID000000702
Drug	Methylergometrine maleate [113-42-8]; Up 200; 8.8uM; PC3; HT_HG-U133A	CUL3 SNED1 ZNF268 ADCY2	2.02e-04	196	34	4	6704_UP
Drug	Lithocholic acid [434-13-9]; Down 200; 10.6uM; PC3; HT_HG-U133A	CUL3 NTNG1 XDH NOS1	2.02e-04	196	34	4	3816_DN
Drug	3-nitropropionic acid; Up 200; 10uM; MCF7; HT_HG-U133A	AMBP LRP2 NTNG1 ADAM28	2.06e-04	197	34	4	6367_UP
Drug	Esculin Hydrate [531-75-9]; Up 200; 11.8uM; MCF7; HT_HG-U133A	KLHL3 GCK ADCY2 ADAM28	2.06e-04	197	34	4	3390_UP
Drug	uric acid	AMBP XDH WWOX AOX1	2.14e-04	199	34	4	CID000001175
Drug	Piribedil hydrochloride [78213-63-5]; Up 200; 12uM; PC3; HT_HG-U133A	XDH WWOX ADCY2 ADAM28	2.18e-04	200	34	4	6333_UP
Drug	Xyl-Glc	XDH WWOX	2.25e-04	15	34	2	CID003083150
Drug	coenzyme 1	XDH ZNF217 GCK WWOX ADCY2 AOX1	2.26e-04	596	34	6	CID000000925
Drug	thiosulfate	XDH WWOX AOX1	2.31e-04	80	34	3	CID000001084
Drug	hydroxyl radical	XDH WWOX NOS1 AOX1	2.44e-04	206	34	4	CID000157350
Drug	biopterin	AMBP WWOX NOS1	2.49e-04	82	34	3	CID000002380
Drug	o-aminobenzaldehyde	WWOX AOX1	2.56e-04	16	34	2	CID000068255
Drug	PQQ cofactor	XDH WWOX	2.56e-04	16	34	2	CID000363188
Drug	Sodium thioglucse	XDH WWOX	2.56e-04	16	34	2	CID000151466
Drug	pyridine N-oxide	AMBP XDH	2.56e-04	16	34	2	CID000012753
Drug	Tag Peptide	BIRC6 AOX1	2.90e-04	17	34	2	CID005486959
Drug	alternariol	XDH AOX1	2.90e-04	17	34	2	CID005359485
Drug	hexonate	WWOX AOX1	2.90e-04	17	34	2	CID000199748
Drug	hypoxanthine	XDH WWOX ADAM28 AOX1	3.13e-04	220	34	4	CID000000790
Drug	isocycloheximide	LRP2 XDH WWOX BIRC6 NOS1 PI15 ADCY2	3.22e-04	905	34	7	CID000002900
Drug	isosorbide-5-mononitrate	XDH BIRC6	3.26e-04	18	34	2	CID000027661
Drug	AC1L1B45	WWOX AOX1	3.26e-04	18	34	2	CID000001275
Drug	AC1O7EMV	XDH WWOX	3.26e-04	18	34	2	CID005460650
Drug	Flavin-Adenine Dinucleotide	XDH NOS1	3.26e-04	18	34	2	DB03147
Drug	CPD-4	XDH WWOX AOX1	3.27e-04	90	34	3	CID000000459
Drug	2-Acetylaminofluorene	ZMAT3 XDH WWOX AOX1 SLC16A10	3.31e-04	409	34	5	ctd:D015073
Drug	syringaldazine	WWOX AOX1	3.64e-04	19	34	2	CID005379425
Drug	SK&F 82958	NOS1 ADCY2	3.64e-04	19	34	2	ctd:C071262
Drug	phenazine	XDH WWOX NOS1	3.83e-04	95	34	3	CID000004757
Drug	DCPIP	XDH WWOX NOS1	3.83e-04	95	34	3	CID000013726
Drug	propranolol	AMBP BIRC6 NOS1 ADCY2 AOX1	4.34e-04	434	34	5	CID000004946
Drug	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin	XDH NOS1	4.47e-04	21	34	2	ctd:C502230
Drug	BQ-788	GCK AOX1	4.47e-04	21	34	2	CID003081333
Drug	26 C	LRP2 WWOX	4.47e-04	21	34	2	CID005327159
Drug	Ibuprofen	AMBP ZMAT3 PKHD1L1 NOS1 SLC16A10	4.48e-04	437	34	5	ctd:D007052
Drug	NSC 117356	XDH WWOX NOS1 AOX1	4.78e-04	246	34	4	CID000004112
Drug	diphenyl sulfoxide	XDH AOX1	4.91e-04	22	34	2	CID000013679
Drug	benznidazole	XDH AOX1	4.91e-04	22	34	2	CID000031593
Drug	acriflavine	XDH WWOX	4.91e-04	22	34	2	CID000002016
Drug	nitrite ion	AMBP XDH WWOX NOS1	5.31e-04	253	34	4	CID000000946
Drug	N1-methylnicotinamide	XDH AOX1	5.37e-04	23	34	2	CID000000457
Drug	phenanthridine	XDH AOX1	5.37e-04	23	34	2	CID000009189
Drug	indophenol blue	XDH WWOX NOS1	5.58e-04	108	34	3	CID000067235
Drug	zinc superoxide	XDH WWOX NOS1	5.58e-04	108	34	3	CID000014809
Drug	trimetoquinol	XDH ADCY2	5.85e-04	24	34	2	CID000005581
Drug	mangrove	PIKFYVE LRP2 GCK NOS1 ADCY2	6.11e-04	468	34	5	CID000000965
Disease	xanthinuria (implicated_via_orthology)	XDH AOX1	1.29e-06	2	34	2	DOID:0060236 (implicated_via_orthology)
Disease	Pseudohypoaldosteronism type 2A	CUL3 KLHL3	7.72e-06	4	34	2	cv:C1840389
Disease	Pseudohypoaldosteronism, type 2	CUL3 KLHL3	7.72e-06	4	34	2	cv:C1449844
Disease	pseudohypoaldosteronism (is_implicated_in)	CUL3 KLHL3	3.59e-05	8	34	2	DOID:4479 (is_implicated_in)
Disease	anorexia nervosa	LRP2 NTNG1 WWOX	7.26e-05	70	34	3	MONDO_0005351
Disease	X-11444 measurement	XDH BIRC6	9.97e-05	13	34	2	EFO_0021237
Disease	Nerve Degeneration	ZMAT3 XDH NOS1	1.21e-04	83	34	3	C0027746
Disease	hypertension (implicated_via_orthology)	LRP2 XDH NOS1	4.32e-04	128	34	3	DOID:10763 (implicated_via_orthology)
Disease	verbal-numerical reasoning measurement	WDR17 BIRC6 FBN3	4.63e-04	131	34	3	EFO_0008394
Disease	multiple system atrophy	XDH PKHD1L1	9.78e-04	40	34	2	EFO_1001050
Disease	end stage renal disease (biomarker_via_orthology)	LRP2 NOS1	1.35e-03	47	34	2	DOID:783 (biomarker_via_orthology)
Disease	ocular hypertension, response to triamcinolone acetonide	ZNF217 VWA8	1.46e-03	49	34	2	EFO_0006954, EFO_1001069
Disease	colorectal health	WWOX VWA8 HACE1	1.59e-03	201	34	3	EFO_0008460
Disease	acute graft vs. host disease	CUL3 WWOX	1.78e-03	54	34	2	EFO_0004599
Disease	vascular endothelial growth factor measurement	SEMA5B VWA8	1.91e-03	56	34	2	EFO_0004762
Disease	vital capacity	CUL3 LRP2 WWOX LPAR5 ADAM28 FBN3	2.62e-03	1236	34	6	EFO_0004312
Disease	congenital heart disease (implicated_via_orthology)	LRP2 ADCY2	2.88e-03	69	34	2	DOID:1682 (implicated_via_orthology)
Disease	Manic Disorder	NTNG1 ADCY2	3.05e-03	71	34	2	C0024713

Protein segments in the cluster

Peptide	Gene	Start	Entry
CQLGYSAGPCMGMTS	AMBP	231	P02760
GTSMACETFQYGGCM	AMBP	251	P02760
MACGYMGRQGSLATC	BIRC6	3061	Q9NR09
VGLAFMSTMCSPYSV	ADAM28	306	Q9UKQ2
CLCYDGFMATPDMRT	FBN3	1221	Q75N90
GTQCGFCTPGMVMSI	AOX1	111	Q06278
EVGMIVGTGCNACYM	GCK	221	P35557
FVVSGTCAEQMYGMC	PSMB3	136	P49720
TTGAIFQMNMYGSCI	LPAR5	96	Q9H1C0
IQAFYMCCSCQMPPG	HACE1	456	Q8IYU2
QLSGSTYCMPMCSST	LRP2	3501	P98164
CTEYICMGSIMHPSQ	NOS1	331	P29475
SYQCPSMFCDTPMVH	PIKFYVE	1266	Q9Y2I7
CLVAMGYLFMCFGGT	ADCY2	116	Q08462
QPMTYPMDNCSTTAC	KLHL21	406	Q9UJP4
VPNGLKTMCECMSSY	CUL3	306	Q13618
CSPYFCAMFTGDMSE	KLHL3	71	Q9UH77
VQRMMGLCCGYQSTF	DNAH9	996	Q9NYC9
CVSCMPGTYQDMEGQ	SCUBE1	646	Q8IWY4
PETFCAMGNPYMCNN	NTNG1	76	Q9Y2I2
CFVIGSIMYGCVTLM	SLC9A6	191	Q92581
MMISVCFPCVGYSVP	WDR17	1016	Q8IZU2
MPCNMNTQCPDGGYC	SNED1	506	Q8TER0
MSFSPYSTMITVCVC	LINC00173	1	Q6ZV60
CQQMYMGEKPFGCSC	ZNF268	266	Q14587
CAFPMEKGPCQTYMT	SPINT3	36	P49223
LGGMYFNNCCRCMPS	WWOX	371	Q9NZC7
SQCGFCTPGIVMSMY	XDH	111	P47989
VFMCGTNAFSPMCTS	SEMA5B	196	Q9P283
CSYNIPMMAVSFGQI	PKHD1L1	886	Q86WI1
LAMCVTPSGQFYCSM	ZMAT3	236	Q9HA38
GYMPLDCMFCSQTFT	ZNF217	61	O75362
CPMRCFGPMCTHYTQ	PI15	161	O43692
VTCNPASLYFMNMTG	VWA8	1131	A3KMH1
SMGMIFFCCPIVSVF	SLC16A10	121	Q8TF71