Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	GNA11 NT5C3B PDE4B PDE6B POLD1 ACOT13 RAD50	6.11e-04	807	37	7	GO:0016788
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE4B PDE6B	7.54e-04	22	37	2	GO:0004115
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	GNA11 PDE4B PDE6B	7.66e-04	97	37	3	GO:0008081
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE4B PDE6B	8.99e-04	24	37	2	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE4B PDE6B	9.76e-04	25	37	2	GO:0004114
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE4B PDE6B	1.14e-03	27	37	2	GO:0004112
MousePheno	absent photoreceptor outer segment	LPCAT1 CLCN7 PDE6B	8.69e-06	18	32	3	MP:0008585
MousePheno	abnormal photoreceptor outer segment number	LPCAT1 CLCN7 PDE6B	1.21e-05	20	32	3	MP:0020815
Domain	PDEase	PDE4B PDE6B	6.05e-04	19	36	2	IPR023088
Domain	PDEase_I	PDE4B PDE6B	7.41e-04	21	36	2	PF00233
Domain	PDEASE_I	PDE4B PDE6B	7.41e-04	21	36	2	PS00126
Domain	PDEase_CS	PDE4B PDE6B	7.41e-04	21	36	2	IPR023174
Domain	-	PDE4B PDE6B	8.14e-04	22	36	2	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE4B PDE6B	8.91e-04	23	36	2	IPR002073
Domain	HDc	PDE4B PDE6B	9.71e-04	24	36	2	SM00471
Domain	HD/PDEase_dom	PDE4B PDE6B	9.71e-04	24	36	2	IPR003607
Pubmed	Using siRNA to define functional interactions between melanopsin and multiple G Protein partners.	GNA11 PDE6B	1.65e-05	6	37	2	24958088
Pubmed	Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.	TRRAP RAD50	1.65e-05	6	37	2	20070254
Pubmed	TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi.	FKBP15 GOLGA4	3.07e-05	8	37	2	29084197
Pubmed	Proteomic characterization of the human sperm nucleus.	AKAP3 MAP3K7 ACOT13 TMEM89 GPC4	9.68e-05	438	37	5	21630459
Pubmed	Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.	GNA11 PDE6B	2.28e-04	21	37	2	30270038
Pubmed	Overview of PDEs and their regulation.	PDE4B PDE6B	3.25e-04	25	37	2	17307970
Pubmed	Interactome of the negative regulator of nuclear import BRCA1-binding protein 2.	AKAP3 SHCBP1L	3.52e-04	26	37	2	25820252
Pubmed	Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein.	MAP3K7 TRRAP	3.80e-04	27	37	2	18838386
Pubmed	GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma.	MAP3K7 POLD1	5.69e-04	33	37	2	34841685
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	TMPPE ACACA NOS2 GPC4	5.87e-04	363	37	4	14691545
Pubmed	A quantitative telomeric chromatin isolation protocol identifies different telomeric states.	POLD1 RAD50	6.05e-04	34	37	2	24270157
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	CD81 ABCA6 NOS2 POLD1	6.57e-04	374	37	4	19625176
Pubmed	An investigation into the human serum "interactome".	AP4E1 PDE4B ABCA6	6.86e-04	162	37	3	15174051
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	CD81 ABCA6 NOS2 POLD1	7.04e-04	381	37	4	18676680
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	CD81 ABCA6 NOS2 POLD1	7.11e-04	382	37	4	19170196
Pubmed	Mouse model resources for vision research.	LPCAT1 PDE6B	8.80e-04	41	37	2	21052544
Pubmed	Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB.	GNA11 CD81	1.01e-03	44	37	2	30024968
Pubmed	Mouse models of ocular diseases.	LPCAT1 PDE6B	1.01e-03	44	37	2	16332269
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	CD81 ABCA6 NOS2 POLD1	1.02e-03	421	37	4	19692168
Cytoband	4q25	RRH TACR3	1.35e-03	67	37	2	4q25
GeneFamily	Phosphodiesterases	PDE4B PDE6B	3.49e-04	24	21	2	681
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	FKBP15 CLCN7	1.85e-02	181	21	2	694
Coexpression	GSE27786_CD4_TCELL_VS_ERYTHTROBLAST_UP	NT5C3B PDE4B GOLGA4 TMEM161B PHTF1	8.79e-06	200	37	5	M4827
Drug	1pzj	MAP3K7 PDE6B TRRAP NOS2 GOLGA4	6.27e-06	167	36	5	CID000447976
Drug	P-NE	RRH AKAP3 PDE4B PDE6B NOS2	6.65e-06	169	36	5	CID000446755
Drug	EHNA	RRH NT5C3B PDE4B PDE6B	1.07e-05	87	36	4	CID000003206
Drug	Xylazine [7361-61-7]; Down 200; 18.2uM; PC3; HT_HG-U133A	CHRNA10 CPLANE1 PDE6B RAD50 GPC4	1.40e-05	197	36	5	4066_DN
Drug	T-0156	PDE6B NOS2	2.42e-05	5	36	2	CID000005368
Drug	septilin	PDE4B NOS2	2.42e-05	5	36	2	ctd:C047352
Drug	vardenafil	PDE4B PDE6B NOS2	2.72e-05	37	36	3	CID000110634
Disease	Asthma	PDE4B NOS2 RAD50	9.87e-05	80	33	3	C0004096
Disease	Hypogonadotropic hypogonadism	TACR3 POLD1	1.26e-04	15	33	2	C0271623
Disease	Primary hypogonadism	TACR3 POLD1	1.26e-04	15	33	2	C0948896
Disease	Hypogonadism, Isolated Hypogonadotropic	TACR3 POLD1	1.26e-04	15	33	2	C3489396
Disease	Hypogonadism	TACR3 POLD1	1.44e-04	16	33	2	C0020619
Disease	anterior uveitis	CLCN7 NOS2	5.89e-04	32	33	2	EFO_1000811
Disease	Cholestasis, Extrahepatic	MAP3K7 NOS2	5.89e-04	32	33	2	C0005398
Disease	dilated cardiomyopathy (is_marker_for)	MAP3K7 NOS2	8.76e-04	39	33	2	DOID:12930 (is_marker_for)
Disease	Cutaneous Melanoma	GNA11 TRRAP	9.68e-04	41	33	2	C0151779
Disease	Congenital Heart Defects	GNA11 TRRAP	1.11e-03	44	33	2	C0018798
Disease	Alcohol Use Disorder	PDE4B TACR3	1.11e-03	44	33	2	C0001956

Protein segments in the cluster

Peptide	Gene	Start	Entry
MTSMTQSLREVIKAM	ACOT13	1	Q9NPJ3
MTMVTFSTALTILIM	CHRNA10	306	Q9GZZ6
MAEEVSTLMKATVLM	NT5C3B	1	Q969T7
TMTIMVEDIMKLLCS	C19orf12	11	Q9NSK7
MEELMSVTAITMKTL	ABCA6	196	Q8N139
EIEVMKMVMTLTAVE	ACACA	781	Q13085
VVAVIMIFEMILSMV	CD81	211	P60033
TTTLKMMKECMVRLI	AP4E1	71	Q9UPM8
EMMIVMRTTELVNKD	RAD50	1106	Q92878
IDVTKMSVIMICMFL	RRH	236	O14718
CMLMRKTMASRVRVT	NOS2	526	P35228
AIPVTMTMSSIVMKA	LPCAT1	141	Q8NF37
ILRQIMALRVMTSKM	GPC4	461	O75487
MMGRETKTMAKVITT	GOLGA4	2186	Q13439
RMTLSLTVIMMEATS	CLCN7	561	P51798
LRKMVIDMVLATDMS	PDE4B	506	Q07343
LETTRKEIVMAMMMT	PDE6B	701	P35913
VTMETSMIMSNIQRI	FKBP15	556	Q5T1M5
SMEEIVKIMTHLMRY	MAP3K7	276	O43318
EEMMSVVMHSIQKVR	CPLANE1	1401	Q9H799
AMQAMIRAMETLKIL	GNA11	86	P29992
VRMMQAQEAVSRIKM	APBA1	481	Q02410
TKVVSMVGRVQMDML	POLD1	446	P28340
TSMEDLQKMMVVALI	FAM8A1	296	Q9UBU6
ERKITLMVMMVVMVF	SSTR1	266	P30872
IQLVVTMVMASVMQK	TMEM161B	6	Q8NDZ6
TITHIVAKMMTTEMI	SHCBP1L	381	Q9BZQ2
KVVKMMIIVVMTFAI	TACR3	296	P29371
SVVSDMMVSIMKTLK	AKAP3	291	O75969
RMSIEMEAMKTNILL	CCDC110	566	Q8TBZ0
KMDMSVLEISGIIMS	PHTF1	451	Q9UMS5
MRTVVLTMKASVIEM	VIT	1	Q6UXI7
VSNIFLTIRMMMKIS	TLCD1	146	Q96CP7
AVMITTTMLMICRKI	TMEM89	71	A2RUT3
SIMLMARMVATVKQA	SMYD5	166	Q6GMV2
VKTRLAVMSMEMRKN	TRRAP	2331	Q9Y4A5
VGRTKMEMFVRMVNV	TMPPE	221	Q6ZT21