Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	GLI-SUFU complex	GLI1 SUFU	1.05e-04	4	88	2	GO:1990788
Pubmed	Distinct Activities of Gli1 and Gli2 in the Absence of Ift88 and the Primary Cilia.	GLI1 NKX6-1 SUFU	3.01e-06	11	93	3	30791390
Pubmed	Dual function of suppressor of fused in Hh pathway activation and mouse spinal cord patterning.	GLI1 NKX6-1 SUFU	4.00e-06	12	93	3	22182519
Pubmed	Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord.	GLI1 NKX6-1 SUFU	4.00e-06	12	93	3	28412462
Pubmed	Polymorphism of the ACE Gene in dialysis patients: overexpression of DD genotype in type 2 diabetic end-stage renal failure patients.	ACAA1 ACE	7.07e-06	2	93	2	16385653
Pubmed	Effect of the angiotensin-converting enzyme gene deletion polymorphism on the risk of venous thromboembolism.	ACE F5	7.07e-06	2	93	2	11122103
Pubmed	Evaluation of the roles of the Leiden V mutation and ACE I/D polymorphism in subtypes of ischaemic stroke.	ACE F5	7.07e-06	2	93	2	11596779
Pubmed	Lithium Suppresses Hedgehog Signaling via Promoting ITCH E3 Ligase Activity and Gli1-SUFU Interaction in PDA Cells.	GLI1 SUFU	7.07e-06	2	93	2	29249966
Pubmed	A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation.	TICAM1 IRF3	7.07e-06	2	93	2	20418377
Pubmed	Chlamydia muridarum infection elicits a beta interferon response in murine oviduct epithelial cells dependent on interferon regulatory factor 3 and TRIF.	TICAM1 IRF3	7.07e-06	2	93	2	17178782
Pubmed	Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1.	GLI1 SUFU	7.07e-06	2	93	2	10559945
Pubmed	Characterization of the physical interaction of Gli proteins with SUFU proteins.	GLI1 SUFU	7.07e-06	2	93	2	12426310
Pubmed	The frequency of factor V Leiden mutation, ACE gene polymorphism, serum ACE activity and response to ACE inhibitor and angiotensin II receptor antagonist drugs in Iranians type II diabetic patients with microalbuminuria.	ACE F5	7.07e-06	2	93	2	20853144
Pubmed	Angiotensin-converting enzyme genotype and the ventilatory response to exertional hypoxia.	ACAA1 ACE	7.07e-06	2	93	2	14621081
Pubmed	SRPX and HMCN1 regulate cancer‑associated fibroblasts to promote the invasiveness of ovarian carcinoma.	HMCN1 SRPX	7.07e-06	2	93	2	31638245
Pubmed	Induction of Hsp22 (HspB8) by estrogen and the metalloestrogen cadmium in estrogen receptor-positive breast cancer cells.	ESR1 HSPB8	7.07e-06	2	93	2	18229450
Pubmed	Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.	GLI1 GNAS	7.07e-06	2	93	2	25961504
Pubmed	Association among ACE, ESR1 polymorphisms and preeclampsia in Brazilian pregnant women.	ESR1 ACE	7.07e-06	2	93	2	31028794
Pubmed	Expression of Gli1 correlates with the transition of breast cancer cells to estrogen-independent growth.	GLI1 ESR1	7.07e-06	2	93	2	19191023
Pubmed	The relationship of the factor V Leiden mutation or the deletion-deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty.	ACE F5	7.07e-06	2	93	2	11311153
Pubmed	Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis.	GLI1 SUFU	7.07e-06	2	93	2	25373737
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	MDN1 ARHGEF10 KHNYN CHD9 RUSC2	9.15e-06	104	93	5	9205841
Pubmed	Poor replication of candidate genes for major depressive disorder using genome-wide association data.	HTR1A AVPR1B ESR1 ACE	1.09e-05	51	93	4	20351714
Pubmed	Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses.	TICAM1 IRF3	2.12e-05	3	93	2	15841462
Pubmed	Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs.	GLI1 SUFU	2.12e-05	3	93	2	21816948
Pubmed	Interferon response factor 3 is essential for house dust mite-induced airway allergy.	TICAM1 IRF3	2.12e-05	3	93	2	20673978
Pubmed	The crosstalk of mTOR/S6K1 and Hedgehog pathways.	GLI1 SUFU	2.12e-05	3	93	2	22439934
Pubmed	Arhgap36-dependent activation of Gli transcription factors.	GLI1 SUFU	2.12e-05	3	93	2	25024229
Pubmed	IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice.	TICAM1 IRF3	2.12e-05	3	93	2	20720199
Pubmed	Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization.	GLI1 SUFU	2.12e-05	3	93	2	24854174
Pubmed	Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.	GLI1 SUFU	2.12e-05	3	93	2	24217340
Pubmed	Rab23 negatively regulates Gli1 transcriptional factor in a Su(Fu)-dependent manner.	GLI1 SUFU	2.12e-05	3	93	2	22365972
Pubmed	Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.	GLI1 SUFU	2.12e-05	3	93	2	28965847
Pubmed	Protein phosphatase 5 is a negative regulator of estrogen receptor-mediated transcription.	PPP5C ESR1	2.12e-05	3	93	2	14764652
Pubmed	The ACE D/D genotype is protective against the development of idiopathic deep vein thrombosis and pulmonary embolism.	ACE F5	2.12e-05	3	93	2	14597977
Pubmed	Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.	ESR1 POLR1B	2.12e-05	3	93	2	11953755
Pubmed	Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.	GLI1 SUFU	2.12e-05	3	93	2	24311597
Pubmed	SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell.	GLI1 SUFU	2.12e-05	3	93	2	18829525
Pubmed	Overestimation of genetic risks owing to small sample sizes in cardiovascular studies.	ACE F5	2.12e-05	3	93	2	12791034
Pubmed	Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.	GLI1 SUFU	2.12e-05	3	93	2	21543335
Pubmed	Mutations in SUFU predispose to medulloblastoma.	GLI1 SUFU	2.12e-05	3	93	2	12068298
Pubmed	Combined effect of Factor V Leiden, MTHFR, and angiotensin-converting enzyme (insertion/deletion) gene mutations in hypertensive adult individuals: a population-based study from Sivas and Canakkale, Turkey.	ACE F5	2.12e-05	3	93	2	21699409
Pubmed	[A study of relationship between oral contraceptives and gene polymorphism and types of stroke].	ACE F5	2.12e-05	3	93	2	11718065
Pubmed	ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1.	GLI1 SUFU	2.12e-05	3	93	2	35831023
Pubmed	Genetic factors for obesity.	ESR1 ACE	2.12e-05	3	93	2	17016614
Pubmed	Trans-ethnic predicted expression genome-wide association analysis identifies a gene for estrogen receptor-negative breast cancer.	ESR1 TP53INP2	2.12e-05	3	93	2	28957356
Pubmed	Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery.	ACE F5	2.12e-05	3	93	2	21955693
Pubmed	Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model.	GLI1 NKX6-1 SUFU	2.38e-05	21	93	3	28688895
Pubmed	Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway.	GLI1 NKX6-1 SUFU	2.75e-05	22	93	3	19223390
Pubmed	Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.	GLI1 NKX6-1 SUFU	3.15e-05	23	93	3	16459298
Pubmed	IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3.	TICAM1 IRF3	4.23e-05	4	93	2	17548596
Pubmed	Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-β and RANTES production.	TICAM1 IRF3	4.23e-05	4	93	2	21248248
Pubmed	Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes.	TICAM1 IRF3	4.23e-05	4	93	2	23918362
Pubmed	Relationship between preterm labor and thrombophilic gene polymorphism: A prospective sequential cohort study.	ACE F5	4.23e-05	4	93	2	19776610
Pubmed	MicroRNA-181b-2 and MicroRNA-21-1 Negatively Regulate NF-κB and IRF3-Mediated Innate Immune Responses via Targeting TRIF in Teleost.	TICAM1 IRF3	4.23e-05	4	93	2	34956174
Pubmed	Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.	TICAM1 IRF3	4.23e-05	4	93	2	14739303
Pubmed	Maternal IVS1-401 T allele of the estrogen receptor alpha is an independent predictor of late fetal loss.	ESR1 F5	4.23e-05	4	93	2	16753154
Pubmed	Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1.	GLI1 SUFU	4.23e-05	4	93	2	10531011
Pubmed	Genetic polymorphisms associated with retinal vein occlusion: a Greek case-control study and meta-analysis.	ACE F5	4.23e-05	4	93	2	23289804
Pubmed	ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function.	PPP3CB MSS51	4.23e-05	4	93	2	21531385
Pubmed	MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function.	GLI1 SUFU	4.23e-05	4	93	2	29662197
Pubmed	Prevalence of thrombophilic mutations and ACE I/D polymorphism in Turkish ischemic stroke patients.	ACE F5	4.23e-05	4	93	2	18387982
Pubmed	Genetic factors associated with thrombosis in pregnancy in a United States population.	ACE F5	4.23e-05	4	93	2	11084577
Pubmed	Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms.	GLI1 SUFU	4.23e-05	4	93	2	16316410
Pubmed	Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells.	GLI1 SUFU	4.23e-05	4	93	2	30973324
Pubmed	Homo-oligomerization is essential for Toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-kappaB and interferon regulatory factor-3 activation.	TICAM1 IRF3	4.23e-05	4	93	2	18450748
Pubmed	Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors.	TICAM1 IRF3	4.23e-05	4	93	2	22308357
Pubmed	Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.	GLI1 NKX6-1 SUFU	6.43e-05	29	93	3	21209331
Pubmed	Interferon regulatory factor 3 deficiency leads to interleukin-17-mediated liver ischemia-reperfusion injury.	TICAM1 IRF3	7.04e-05	5	93	2	22911673
Pubmed	Normal embryonic and germ cell development in mice lacking alpha 1,3-fucosyltransferase IX (Fut9) which show disappearance of stage-specific embryonic antigen 1.	MDN1 FUT4	7.04e-05	5	93	2	15121843
Pubmed	Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partner.	GLI1 SUFU	7.04e-05	5	93	2	10920228
Pubmed	Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotension.	GNAS ACE	7.04e-05	5	93	2	11910300
Pubmed	The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.	TICAM1 IRF3	7.04e-05	5	93	2	18382764
Pubmed	Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.	GLI1 SUFU	7.04e-05	5	93	2	21076395
Pubmed	PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis.	TICAM1 IRF3	7.04e-05	5	93	2	15251447
Pubmed	The Lyme disease spirochete Borrelia burgdorferi utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes.	TICAM1 IRF3	7.04e-05	5	93	2	20404081
Pubmed	Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.	TICAM1 IRF3	7.04e-05	5	93	2	19656901
Pubmed	Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells.	TICAM1 IRF3	7.04e-05	5	93	2	21441453
Pubmed	A conventional protein kinase C inhibitor targeting IRF-3-dependent genes differentially regulates IL-12 family members.	TICAM1 IRF3	7.04e-05	5	93	2	21550664
Pubmed	Evaluation of the modifying effects of unfavourable genotypes on classical clinical risk factors for ischaemic stroke.	ACE F5	7.04e-05	5	93	2	14638877
Pubmed	Thrombophilic polymorphisms in preterm delivery.	ACE F5	7.04e-05	5	93	2	15223011
Pubmed	Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation.	TICAM1 IRF3	7.04e-05	5	93	2	17275788
Pubmed	Inhibition of viral pathogenesis and promotion of the septic shock response to bacterial infection by IRF-3 are regulated by the acetylation and phosphorylation of its coactivators.	TICAM1 IRF3	7.04e-05	5	93	2	23532979
Pubmed	Prevalence of angiotensin-converting enzyme, methylenetetrahydrofolate reductase, Factor V Leiden, prothrombin and apolipoprotein E gene polymorphisms in Morocco.	ACE F5	7.04e-05	5	93	2	20687780
Pubmed	Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling.	GLI1 SUFU	7.04e-05	5	93	2	26120032
Pubmed	Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.	TICAM1 IRF3	7.04e-05	5	93	2	21059856
Pubmed	Thrombophilic gene polymorphisms and recurrent pregnancy loss in Greek women.	ACE F5	7.04e-05	5	93	2	28603947
Pubmed	The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model.	TICAM1 IRF3	7.04e-05	5	93	2	24078691
Pubmed	Gli regulation by the opposing activities of fused and suppressor of fused.	GLI1 SUFU	7.04e-05	5	93	2	10806483
Pubmed	TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol.	TICAM1 IRF3	7.04e-05	5	93	2	18713975
Pubmed	Genetic risk factors for arterial ischemic stroke in children: a possible MTHFR and eNOS gene-gene interplay?	ACE F5	7.04e-05	5	93	2	19372095
Pubmed	Candidate genetic risk factors of stroke: results of a multilocus genotyping assay.	ACE F5	7.04e-05	5	93	2	17317888
Pubmed	Gene polymorphisms in patients below 35 years of age who underwent coronary artery bypass surgery.	ACE F5	7.04e-05	5	93	2	16374139
Pubmed	[Genetics of blood coagulation in young stroke patients].	ACE F5	7.04e-05	5	93	2	12122980
Pubmed	Dual signaling of MyD88 and TRIF is critical for maximal TLR4-induced dendritic cell maturation.	TICAM1 IRF3	7.04e-05	5	93	2	18641322
Pubmed	Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli.	GLI1 SUFU	7.04e-05	5	93	2	10564661
Pubmed	Neuronal pentraxin with chromo domain (NPCD) is a novel class of protein expressed in multiple neuronal domains.	CBX6 NPTXR	7.04e-05	5	93	2	15593341
Pubmed	Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.	GLI1 NKX6-1 SUFU	8.68e-05	32	93	3	19286674
Pubmed	Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma.	GLI1 FUT4	1.05e-04	6	93	2	19487286
Pubmed	CNBP controls IL-12 gene transcription and Th1 immunity.	TICAM1 IRF3	1.05e-04	6	93	2	30442645
Pubmed	Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence.	TICAM1 IRF3	1.05e-04	6	93	2	20886104
Cytoband	22q13.1	CBX6 NPTXR APOL1	7.05e-04	85	93	3	22q13.1
Cytoband	17q23.3	SCN4A ACE	1.70e-03	30	93	2	17q23.3
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP3CB PPP5C	7.19e-04	13	56	2	693
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MAG HMCN1 FSTL4 LINGO4	1.55e-03	161	56	4	593
ToppCell	E16.5-Endothelial-Endothelial_lymphatic\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HMCN1 LINGO4 GNAS PCDH12 ZNF831 SEZ6	1.23e-06	167	91	6	b93103a868fba63a8910bffb690a6242b9252833
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HMCN1 LINGO4 GNAS PCDH12 ZNF831 SEZ6	1.23e-06	167	91	6	fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HMCN1 LINGO4 GNAS PCDH12 ZNF831 SEZ6	1.23e-06	167	91	6	f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HMCN1 LINGO4 GNAS PCDH12 ZNF831 SEZ6	1.23e-06	167	91	6	26cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCell	Adult-Immune-enucleated_erythrocyte-D231\|Adult / Lineage, Cell type, age group and donor	ZSCAN32 HLA-G MUC16 PCDH12 ACE HSPB8	1.72e-06	177	91	6	15ee303fb6caea1fd645c3b777666196ce500a1c
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Intermediate_Fibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	HIVEP3 DSC1 AVPR1B GLI1 TNS1	9.17e-06	137	91	5	dd5364a1002650d21e0c83d8c701b5f7b09d1c19
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|368C / Donor, Lineage, Cell class and subclass (all cells)	PASK ARHGEF10 FSTL4 PCDH12 ACE	2.32e-05	166	91	5	30a991fc3275b571d53bd0976df4789e5d40b01d
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	PASK ARHGEF10 FSTL4 PCDH12 ACE	2.32e-05	166	91	5	76b4cd32698900797ec009f17e50ea7ae36b85f4
ToppCell	Bronchial_Biopsy-Immune-T_and_NK\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	NPTXR LPCAT4 EGFLAM SRPX ZNF831	2.45e-05	168	91	5	435b2f238fbb3f50427e8cdecf2220615015153c
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PASK ARHGEF10 FSTL4 PCDH12 ACE	2.60e-05	170	91	5	f0b0d2d0402de3ed7322284a599646db43475761
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PASK ARHGEF10 FSTL4 PCDH12 ACE	2.60e-05	170	91	5	054360a3b05f5e41221c98b122d241b1affad26a
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGEF10 APOL1 PCDH12 HSPB8 RUSC2	2.75e-05	172	91	5	e359c59631f6a262429b6896a409f2ffbd4f6a76
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-SMG_basal_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	HCAR2 NEURL3 RASSF6 TICAM1 FSTL4	2.98e-05	175	91	5	4462000b22af227555413ba202a872868eecde6c
ToppCell	Control-Epithelial_cells-Airway_goblet\|Control / group, cell type (main and fine annotations)	NALF1 LPCAT4 MUC16 APOL1 WNK2	3.79e-05	184	91	5	d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAT8L MDN1 SHF LPCAT4 SUFU	3.89e-05	185	91	5	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 GLI1 EGFLAM SRPX GASK1A	3.89e-05	185	91	5	785c55d39909fac74415f24427979691e7e694e6
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 GLI1 EGFLAM SRPX GASK1A	3.89e-05	185	91	5	97a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 GLI1 EGFLAM SRPX GASK1A	3.99e-05	186	91	5	94d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF10 EGFLAM PCDH12 ACE ITPKB	4.20e-05	188	91	5	73f6ec915934154f435a376cb274b058ff7c5f35
ToppCell	COVID-19-kidney-DCT\|kidney / Disease (COVID-19 only), tissue and cell type	GALNT17 NALF1 HMCN1 FSTL4 ITPKB	4.20e-05	188	91	5	df1fd0819d301679f3c9ea404e942e39095912eb
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT17 NALF1 HMCN1 FSTL4 ITPKB	4.31e-05	189	91	5	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT17 NALF1 HMCN1 FSTL4 ITPKB	4.31e-05	189	91	5	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-Activated_CD4_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PASK DSC1 GYPC ZNF831 ITPKB	4.53e-05	191	91	5	dabb2d0210e39455db99db155cb36a3b6af43f37
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF10 EGFLAM PCDH12 ACE ITPKB	4.64e-05	192	91	5	c618ede75dce3988c87a5b8f98d8e94e1dd66efd
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF10 EGFLAM PCDH12 ACE HSPB8	4.76e-05	193	91	5	a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGEF10 FSTL4 PCDH12 ACE HSPB8	5.12e-05	196	91	5	a53caedd0103bd162b3aee8ab87b4442a5e0338f
ToppCell	proximal-Epithelial-Differentiating_Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EPN3 HCAR2 NEURL3 RASSF6 MUC16	5.50e-05	199	91	5	c607346f60e5997e757e5a31cab412ab3734377b
ToppCell	Control_saline\|World / Treatment groups by lineage, cell group, cell type	HMCN1 EGFLAM GNAS PCDH12 ACE	5.50e-05	199	91	5	11c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCell	proximal-3-Epithelial-Differentiating_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EPN3 HCAR2 NEURL3 RASSF6 MUC16	5.50e-05	199	91	5	12e07084fc2d5d4c418df564ccc0e132b056e549
ToppCell	proximal-Epithelial-Differentiating_Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EPN3 HCAR2 NEURL3 RASSF6 MUC16	5.50e-05	199	91	5	96a89a2578fad9a99c52d2cf9e26e06516a96568
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	BPTF FAT4 HMCN1 PCDH12 ACE	5.63e-05	200	91	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ARHGEF10 EGFLAM PCDH12 ACE HSPB8	5.63e-05	200	91	5	66f7e8ee63c828f17468e79a4b816346b33e8980
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	ARHGEF10 EGFLAM PCDH12 ACE HSPB8	5.63e-05	200	91	5	432384faeade8e609154fab3d96c955a8ec868dd
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_basal-Suprabasal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	EPN3 NEURL3 RASSF6 MUC16 WNK2	5.63e-05	200	91	5	ce969c958a31145bbfe315a9a865d7900ecc9549
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Desmoid_Tumor\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	ZNF469 HTR1A DSC1 HMCN1	1.04e-04	119	91	4	d8fbea9ded96fcc3ebdfb4d28873c563427ce811
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Desmoid_Tumor-7\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	ZNF469 HTR1A DSC1 HMCN1	1.04e-04	119	91	4	9e38f13bf98b9ee44b178300e6f80fd08a006296
Disease	Psychoses, Substance-Induced	HTR1A ESR1 ACE	1.81e-05	17	90	3	C0033941
Disease	Psychoses, Drug	HTR1A ESR1 ACE	3.51e-05	21	90	3	C0033937
Disease	non-arteritic anterior ischemic optic neuropathy (is_implicated_in)	ACE F5	9.15e-05	5	90	2	DOID:0050864 (is_implicated_in)
Disease	Herpetic Acute Necrotizing Encephalitis	TICAM1 IRF3	9.15e-05	5	90	2	C0001338
Disease	Herpetic meningoencephalitis	TICAM1 IRF3	1.37e-04	6	90	2	C0019385
Disease	non-melanoma skin carcinoma	ZNF469 TICAM1 HLA-G IRF3 TP53INP2 FANCA	1.64e-04	265	90	6	EFO_0009260
Disease	Herpes encephalitis	TICAM1 IRF3	1.91e-04	7	90	2	C0276226
Disease	brain disease (is_implicated_in)	TICAM1 IRF3	5.95e-04	12	90	2	DOID:936 (is_implicated_in)
Disease	Alzheimer's disease (implicated_via_orthology)	HIVEP3 TM2D1 ACE	7.13e-04	57	90	3	DOID:10652 (implicated_via_orthology)
Disease	peak expiratory flow	NALF1 ESR1 SCN4A MRPL52 MTCL1 NKX6-1 TP53INP2	8.37e-04	498	90	7	EFO_0009718
Disease	Bladder Neoplasm	BPTF GLI1 ESR1 FANCA	9.04e-04	140	90	4	C0005695
Disease	Malignant neoplasm of urinary bladder	BPTF GLI1 ESR1 FANCA	9.29e-04	141	90	4	C0005684
Disease	breast cancer (is_implicated_in)	ESR1 ACE F5 FANCA	1.17e-03	150	90	4	DOID:1612 (is_implicated_in)
Disease	pre-malignant neoplasm (biomarker_via_orthology)	GLI1 SUFU	1.21e-03	17	90	2	DOID:0060071 (biomarker_via_orthology)
Disease	pentachlorophenol measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022071
Disease	parathion measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022070
Disease	potassium chromate measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022072
Disease	mercuric chloride measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022068
Disease	heptachlor epoxide measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022067
Disease	methoxychlor measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022069
Disease	4,6-dinitro-o-cresol measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022053
Disease	2,4,5-trichlorophenol measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022052
Disease	azinphos methyl measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022055
Disease	aldrin measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022054
Disease	dicofol measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022060
Disease	disulfoton measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022062
Disease	dieldrin measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022061
Disease	endrin measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022064
Disease	endosulfan measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022063
Disease	heptachlor measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022066
Disease	ethion measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022065
Disease	chlorpyrifos measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022057
Disease	cadmium chloride measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022056
Disease	diazinon measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022059
Disease	dibutyl phthalate measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0022058
Disease	environmental exposure measurement	MUC16 F5 TNS1	1.46e-03	73	90	3	EFO_0008360
Disease	DDT metabolite measurement	MUC16 F5 TNS1	1.52e-03	74	90	3	EFO_0007886
Disease	psoriatic arthritis	GYPC HLA-G TNS1	2.42e-03	87	90	3	EFO_0003778
Disease	pre-eclampsia (is_implicated_in)	ACE F5	2.64e-03	25	90	2	DOID:10591 (is_implicated_in)
Disease	eye color	HIVEP3 MUC16 ITPKB	2.66e-03	90	90	3	EFO_0003949

Protein segments in the cluster

Peptide	Gene	Start	Entry
PIRAAWSPPSAAMSG	nan	41	Q9H8V8
SAMAPPWLPGIVSAA	nan	66	A8MWP4
TAWEPSRPFPVDMAG	B3GAT3	241	O94766
WSCSMDQREPLPPAP	ARHGEF10	21	O15013
DMRPWPLGKALSGAD	EGFLAM	546	Q63HQ2
SLPMWSTGPEARDGD	CCDC187	96	A0A096LP49
SEPEAGDWRPEMSPC	CBX6	351	O95503
TSLELSPMPPEFWEG	ACE	331	P12821
DPWGPPSSLMSEIAD	EPN3	31	Q9H201
MDLAPDRATGRPWLP	FAT4	1	Q6V0I7
SLRWDDMAAKAPPGG	BPTF	1916	Q12830
MLWEETGAAPAPARA	RASSF6	1	Q6ZTQ3
PRPVAMWPCADADSI	MTCL1	1306	Q9Y4B5
PSSALSWMPEGARPG	NOBOX	641	O60393
SAPDPAWMARLSLPL	PCDH12	1051	Q9NPG4
DSDSACPRMEPRAPW	HLA-G	61	P17693
PMSRGPEDVSWPSRP	MUC16	8831	Q8WXI7
PMSRGPEDVSWPSPL	MUC16	9411	Q8WXI7
WRSQDLAPSPSGMAG	PASK	621	Q96RG2
GMGLWPDSVPSALFA	MDN1	2431	Q9NU22
CGADSNPPPLLTWMR	MAG	261	P20916
MSQGSPGDWAPLDPT	LPCAT4	1	Q643R3
PGAPPRTLTWEAMEQ	NGRN	76	Q9NPE2
PGFHSSPDLMEAWLP	MSS51	356	Q4VC12
DWMAGAVAPPARPPR	GPC2	511	Q8N158
EGASWPAPFEMPSSV	EDRF1	241	Q3B7T1
APEALMANSGEPWSP	HCAR2	341	Q8TDS4
LPVRAMGAPWGSPTA	FUT4	121	P22083
GMDPFPDDLTASWPD	HSPB8	36	Q9UJY1
GSAGDMRAANLWPSP	ESR1	281	P03372
MPWDPSSGSDAPLPA	C19orf85	141	A0A1B0GUS0
EDPSWPSTAMNRAAP	LCT	1236	P09848
ASSLDRIGGLPMPPW	GLI1	606	P08151
RDTMADGPWDSPALI	NPTXR	176	O95502
ESLPEKMRPASWGAP	MFSD14A	211	Q96MC6
GTPAPSMAWLRDGQP	HMCN1	3461	Q96RW7
VSPLPGSDMAALPAW	GASK1A	171	Q9UFP1
PNGLFPDVSDGSPMW	CHD9	111	Q3L8U1
WPSPTPGGRSSELMD	CROCC2	1346	H7BZ55
MAASSVAPPERQGPW	FANCA	731	O15360
SLPAALGWMDPGTSR	FSTL4	16	Q6MZW2
WDAGDPSLPIRTPAM	GALNT17	311	Q6IS24
PMLGWRTPEDRSDPD	HTR1A	171	P08908
PLGDWAAGTMDPESS	APOL1	51	O14791
WAPIPASLMENSLGP	DSC1	136	Q08554
MPTWGARPASPDRFA	KHNYN	1	O15037
AWPLSLEPDPGMASA	GYPC	11	P04921
PPSLREMEEGPEFWA	GADL1	446	Q6ZQY3
PAFGPMCDLLWSDPS	PPP3CB	231	P16298
LPPGTMPSASDWIGI	CALCOCO1	36	Q9P1Z2
SGDGDPAPTVSWMRP	LINGO4	436	Q6UY18
WPVTLPDPGMSLTDR	IRF3	241	Q14653
RPVEFSEFPDPMWGS	MAP3K4	566	Q9Y6R4
METPPWDPARNDSLP	GPR137B	16	O60478
MDLLGPDPSPPWSTQ	RUSC2	606	Q8N2Y8
LRGPADSGWMPQAAP	ACAA1	11	P09110
LPDWSYADGRPAPPM	MRPL52	46	Q86TS9
GLMPISPSDTAWPPA	SCN4A	1806	P35499
AACRMAAGPEPPEWE	RNF187	106	Q5TA31
PSGMRPWEDLPSQDT	F5	901	P12259
GSPSRMRPWKDPPSD	F5	916	P12259
PGVMQSPPWRDARLA	NKX6-1	206	P78426
PSGRMLEPLPCWDAA	ITPKB	471	P27987
PDSGPMCDLLWSDPQ	PPP5C	376	P53041
TGSSPWMEISGPPFE	GNAS	296	Q5JWF2
SEPRMLWGSDPYPHA	PRRC2C	801	Q9Y520
STLSGAAMEPAPRWL	SELENOO	31	Q9BVL4
ENGRPPDPADWAVMD	SAMD13	41	Q5VXD3
EPSLAPMWRENPAGY	WIZ	481	O95785
PMWRENPAGYDPSLA	WIZ	486	O95785
SEGPWGAPREDMTPL	WIZ	1201	O95785
AWSGRPASCVDMEPP	SRPX	166	P78539
TPGWPSRDQEAPGSM	C11orf21	41	Q9P2W6
SMEPSSPLGEWTDPA	SHF	301	Q7M4L6
MDSGPLWDANPTPRG	AVPR1B	1	P47901
DWAQPLLMGRPESPA	ZFR2	561	Q9UPR6
SWASAPPMASDAVPG	ZSCAN32	341	Q9NX65
MRPIDDPGVPSEWTS	RALGAPA1	881	Q6GYQ0
PPAPSLMDESWFVTP	TP53INP2	61	Q8IXH6
MPERELWPAGTGSEP	SARG	1	Q9BW04
AQSSPEAWSFPPMRL	PRR19	341	A6NJB7
APPWLRDMAAAGISS	SAGE2P	141	A6NJ88
EEMSWPPSGEIASPP	TICAM1	251	Q8IUC6
PSPGFGWRAINPSMA	TNS1	1191	Q9HBL0
GWRAINPSMAAPSSP	TNS1	1196	Q9HBL0
SAPPTWPAELMQGLA	SUFU	131	Q9UMX1
GSTWQLVDPMRPGPS	HIVEP3	116	Q5T1R4
MAAAWPSGPSAPEAV	TM2D1	1	Q9BX74
QLRSPWPMTAAGPAS	SCAND2P	146	Q9GZW5
KEGPWSPESESPMLR	SEZ6	136	Q53EL9
VSAWMRALPSPDCPG	SNHG28	181	P0DPA3
LDPTASRLPTPMPWD	NEURL3	171	Q96EH8
PAAWRGLEMPAPADD	ZNF469	2966	Q96JG9
MAANGDSPPWSPALA	ZNF41	1	P51814
WAAPGEARAMTAPRA	WNK2	2201	Q9Y3S1
REAPWDSAPMASPGL	ZNF831	276	Q5JPB2
MDPGSRWRNLPSGPS	POLR1B	1	Q9H9Y6
MGDLPWAPPEAQAPS	nan	1	Q8N6K4
LSAPWLSLFPPEGNM	ZNF263	191	O14978
APLDMPLAEAPASTW	GARIN5B	171	Q8N5Q1
PSWPALLASMGESSP	NALF1	101	B1AL88
LLAAAGAMWPPLPAA	NAT8L	31	Q8N9F0