Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	CACNA1B AOC1 PCLO PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 CBLB OTOF AGRN	5.97e-06	749	102	15	GO:0005509
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	3.48e-07	187	101	9	GO:0007156
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	2.34e-05	313	101	9	GO:0098742
Domain	Cadherin_tail	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	2.51e-13	37	99	9	PF15974
Domain	Cadherin_CBD	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	2.51e-13	37	99	9	IPR031904
Domain	Cadherin_2	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	5.70e-11	65	99	9	PF08266
Domain	Cadherin_N	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	5.70e-11	65	99	9	IPR013164
Domain	Cadherin_CS	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	6.28e-09	109	99	9	IPR020894
Domain	CADHERIN_1	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	8.64e-09	113	99	9	PS00232
Domain	Cadherin	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	8.64e-09	113	99	9	PF00028
Domain	CADHERIN_2	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	9.34e-09	114	99	9	PS50268
Domain	-	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	9.34e-09	114	99	9	2.60.40.60
Domain	CA	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	1.01e-08	115	99	9	SM00112
Domain	Cadherin-like	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	1.09e-08	116	99	9	IPR015919
Domain	Cadherin	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	1.27e-08	118	99	9	IPR002126
Domain	Znf_C2H2/integrase_DNA-bd	ZNF805 ZIM2 ZNF232 ZBTB14 PRDM2 IKZF5 ZNF546 ZSCAN29 ZBTB34 FIZ1 ZNF398 PRDM13 ZNF687 ZNF574	1.72e-05	694	99	14	IPR013087
Domain	Znf_C2H2	ZNF805 ZIM2 TUT1 ZNF232 ZBTB14 PRDM2 IKZF5 ZNF546 ZSCAN29 ZBTB34 FIZ1 ZNF398 PRDM13 ZNF687 ZNF574	2.12e-05	805	99	15	IPR007087
Domain	ZnF_C2H2	ZNF805 ZIM2 TUT1 ZNF232 ZBTB14 PRDM2 IKZF5 ZNF546 ZSCAN29 ZBTB34 FIZ1 ZNF398 PRDM13 ZNF687 ZNF574	2.22e-05	808	99	15	SM00355
Domain	ZINC_FINGER_C2H2_2	ZNF805 ZIM2 ZNF232 ZBTB14 PRDM2 IKZF5 ZNF546 ZSCAN29 ZBTB34 FIZ1 ZNF398 PRDM13 ZNF687 ZNF574	5.75e-05	775	99	14	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF805 ZIM2 ZNF232 ZBTB14 PRDM2 IKZF5 ZNF546 ZSCAN29 ZBTB34 FIZ1 ZNF398 PRDM13 ZNF687 ZNF574	5.91e-05	777	99	14	PS00028
Domain	-	ZNF805 ZIM2 ZNF232 ZBTB14 PRDM2 IKZF5 ZNF546 ZSCAN29 ZBTB34 FIZ1 ZNF398 PRDM13 ZNF574	6.02e-05	679	99	13	3.30.160.60
Domain	zf-C2H2	ZNF805 ZIM2 ZNF232 ZBTB14 PRDM2 ZNF546 ZSCAN29 ZBTB34 FIZ1 ZNF398 PRDM13 ZNF687 ZNF574	7.41e-05	693	99	13	PF00096
Domain	Znf_C2H2-like	ZNF805 ZIM2 ZNF232 ZBTB14 PRDM2 IKZF5 ZNF546 ZSCAN29 ZBTB34 FIZ1 ZNF398 PRDM13 ZNF687 ZNF574	7.65e-05	796	99	14	IPR015880
Domain	TRP_dom	TRPC7 TRPC6	4.11e-04	6	99	2	IPR013555
Domain	TRP_2	TRPC7 TRPC6	4.11e-04	6	99	2	PF08344
Domain	TRPC_channel	TRPC7 TRPC6	5.74e-04	7	99	2	IPR002153
Domain	TRP_channel	TRPC7 TRPC6	1.48e-03	11	99	2	IPR004729
Domain	SET	SETD1A PRDM2 PRDM13	1.86e-03	46	99	3	SM00317
Domain	SET_dom	SETD1A PRDM2 PRDM13	2.36e-03	50	99	3	IPR001214
Domain	SET	SETD1A PRDM2 PRDM13	2.36e-03	50	99	3	PS50280
Domain	PB1	PARD6G PARD6A	2.43e-03	14	99	2	SM00666
Domain	PB1	PARD6G PARD6A	2.43e-03	14	99	2	PF00564
Domain	PB1	PARD6G PARD6A	2.43e-03	14	99	2	PS51745
Domain	PB1_dom	PARD6G PARD6A	2.43e-03	14	99	2	IPR000270
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	6.04e-20	15	103	9	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	2.92e-19	17	103	9	29911975
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	5.82e-19	18	103	9	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	5.82e-19	18	103	9	10662547
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	1.54e-17	24	103	9	24698270
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	8.08e-17	28	103	9	15347688
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4	5.31e-16	11	103	7	9655502
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	9.80e-14	57	103	9	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	1.16e-13	58	103	9	30377227
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	5.23e-13	68	103	9	11230163
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4	5.30e-13	12	103	6	10612399
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	8.94e-13	72	103	9	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	1.16e-12	74	103	9	10817752
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	1.31e-12	75	103	9	15372022
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	1.67e-12	77	103	9	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	2.39e-12	80	103	9	10716726
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	9.06e-11	119	103	9	28625976
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA3 PCDHA2 CUL7 OPTC ELK3	4.23e-09	329	103	11	17474147
Pubmed	Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	6.63e-09	193	103	9	22589738
Pubmed	Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model.	PCDHA11 PCDHA5 PCDHA4	2.09e-06	9	103	3	12154121
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SETD1A MUS81 NOD2 NCOR2 ANKRD11 ZNF398 AP1G2 SAC3D1 PRKDC CABIN1 AGRN HCFC1 PLXNA1 ZNF687	4.88e-06	1105	103	14	35748872
Pubmed	Intron-less processed Pcdhalpha genes in the central nervous system.	PCDHA8 PCDHA6	8.69e-06	2	103	2	14697259
Pubmed	Novel role of NOD2 in mediating Ca2+ signaling: evidence from NOD2-regulated podocyte TRPC6 channels in hyperhomocysteinemia.	TRPC6 NOD2	8.69e-06	2	103	2	23856489
Pubmed	Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II.	TRPC7 TRPC6	8.69e-06	2	103	2	23529130
Pubmed	ALKBH5 regulates paclitaxel resistance in NSCLC via inhibiting CEMIP-mediated EMT.	ALKBH5 CEMIP	8.69e-06	2	103	2	38199493
Pubmed	PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels.	TRPC7 TRPC6	8.69e-06	2	103	2	24470487
Pubmed	Human transcription factor protein interaction networks.	SETD1A COX4I1 RC3H1 CUL7 ZBTB14 PRDM2 IKZF5 NCOR2 ARID1B FAM120A UBXN7 ELK3 CABIN1 HCFC1 ZNF687	2.04e-05	1429	103	15	35140242
Pubmed	MLL5, a histone modifying enzyme, regulates androgen receptor activity in prostate cancer cells by recruiting co-regulators, HCF1 and SET1.	SETD1A HCFC1	2.60e-05	3	103	2	33050986
Pubmed	Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.	TRPC7 TRPC6	2.60e-05	3	103	2	28526717
Pubmed	MEFV, TNFRSF1A and CARD15 mutation analysis in Behçet's disease.	MEFV NOD2	2.60e-05	3	103	2	21385537
Pubmed	The Retinal Basis of Light Aversion in Neonatal Mice.	TRPC7 TRPC6	2.60e-05	3	103	2	35396331
Pubmed	The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection.	SETD1A HCFC1	2.60e-05	3	103	2	17578910
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	MUS81 U2AF2 XAB2 ZBTB14 PRDM2 ZSCAN29 NCOR2 LMO7 FIZ1 ANKRD11 PRKDC CABIN1 HCFC1 ZNF687	2.85e-05	1294	103	14	30804502
Pubmed	Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits.	TRPC7 TRPC6	5.19e-05	4	103	2	30017393
Pubmed	Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.	CBLB PRKDC	5.19e-05	4	103	2	20805496
Pubmed	MEFV, TNF1rA, CARD15 and NLRP3 mutation analysis in PFAPA.	MEFV NOD2	5.19e-05	4	103	2	19579027
Pubmed	Autoinflammatory genes and susceptibility to psoriatic juvenile idiopathic arthritis.	MEFV NOD2	5.19e-05	4	103	2	18576390
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	KPNA4 DIS3L2 RC3H1 U2AF2 GFPT1 XAB2 FAM120A HCFC1	8.00e-05	469	103	8	37314180
Pubmed	Cancer-associated mesothelial cell-derived ANGPTL4 and STC1 promote the early steps of ovarian cancer metastasis.	ANGPTL4 MSLN	8.64e-05	5	103	2	36795484
Pubmed	T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency.	RC3H1 CBLB	8.64e-05	5	103	2	20668237
Pubmed	TRPC channels are necessary mediators of pathologic cardiac hypertrophy.	TRPC7 TRPC6	8.64e-05	5	103	2	20351294
Pubmed	Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits.	TRPC7 TRPC6	8.64e-05	5	103	2	21261756
Pubmed	Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease.	PCDHA12 PCDHA7	8.64e-05	5	103	2	34888534
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	CACNA1B PCLO CUL7 CBLB GFPT1 SPTBN5 DCAF8L1 UTP3	1.18e-04	496	103	8	31343991
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	KPNA4 EXPH5 PPFIA1 LMO7 ANKRD11 UTP3 HCFC1 ZNF687	1.19e-04	497	103	8	36774506
Pubmed	NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells.	PCDHA8 PCDHA6	1.29e-04	6	103	2	24743017
Pubmed	PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.	SETD1A HCFC1	1.29e-04	6	103	2	20622854
Pubmed	The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1.	NOD2 DEDD2	1.29e-04	6	103	2	27273576
Pubmed	Juxtaposition of CNR protocadherins and reelin expression in the developing spinal cord.	PCDHA8 PCDHA6	1.29e-04	6	103	2	11312598
Pubmed	MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.	TRPC7 TRPC6	1.81e-04	7	103	2	15757897
Pubmed	Quick validation of genetic quality for conditional alleles in mice.	SLC39A10 IKZF5	1.81e-04	7	103	2	33540482
Pubmed	Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs.	TRPC7 TRPC6	1.81e-04	7	103	2	38109525
Pubmed	A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.	PARD6G PARD6A	1.81e-04	7	103	2	12629547
Pubmed	RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways.	TRPC7 TRPC6	1.81e-04	7	103	2	32350291
Pubmed	PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions.	PARD6G PARD6A	1.81e-04	7	103	2	12459187
Pubmed	A novel function for human factor C1 (HCF-1), a host protein required for herpes simplex virus infection, in pre-mRNA splicing.	U2AF2 HCFC1	1.81e-04	7	103	2	12456665
Pubmed	TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis.	TRPC7 TRPC6	1.81e-04	7	103	2	36592529
Pubmed	Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models.	TRPC7 TRPC6	1.81e-04	7	103	2	15336983
Pubmed	TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer.	TRPC7 TRPC6	1.81e-04	7	103	2	38835669
Pubmed	TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3.	NOD2 DEDD2	1.81e-04	7	103	2	23376921
Pubmed	The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells.	PARD6G PARD6A	1.81e-04	7	103	2	23439680
Pubmed	Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes.	TRPC7 TRPC6	1.81e-04	7	103	2	36257322
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1B TRPC7 TRPC6	1.97e-04	38	103	3	30786075
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	U2AF2 ALKBH5 XAB2 PRKDC UTP3 HCFC1	2.03e-04	283	103	6	30585729
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	MUS81 U2AF2 CBLB XAB2 CEPT1 FAM120A LMO7 PRKDC UTP3 ZNF687	2.14e-04	847	103	10	35850772
Pubmed	The functional interactome landscape of the human histone deacetylase family.	KPNA4 XAB2 NCOR2 ANKRD11 PRKDC ZNF687	2.28e-04	289	103	6	23752268
Pubmed	Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells.	PARD6G PARD6A	2.40e-04	8	103	2	12203721
Pubmed	Subunit composition of mammalian transient receptor potential channels in living cells.	TRPC7 TRPC6	2.40e-04	8	103	2	12032305
Pubmed	Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction.	CGB1 PRKDC	2.40e-04	8	103	2	17478551
Pubmed	Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels.	TRPC7 TRPC6	2.40e-04	8	103	2	25471572
Pubmed	Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.	PARD6G PARD6A	2.40e-04	8	103	2	11260256
Pubmed	Association of immunophilins with mammalian TRPC channels.	TRPC7 TRPC6	2.40e-04	8	103	2	15199065
Pubmed	RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina.	COX4I1 NDUFV1 HCFC1	2.66e-04	42	103	3	26876175
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	MRPS30 PRKDC ZNF574	3.06e-04	44	103	3	26471122
Pubmed	Lack of association between genetic variation in 9 innate immunity genes and baseline CRP levels.	MEFV NOD2	3.08e-04	9	103	2	16907704
Pubmed	The Krüppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway.	U2AF2 XAB2	3.08e-04	9	103	2	17289029
Pubmed	Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity.	PARD6G PARD6A	3.08e-04	9	103	2	18562307
Pubmed	Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels.	TRPC7 TRPC6	3.08e-04	9	103	2	11290752
Pubmed	Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.	PARD6G PARD6A	3.08e-04	9	103	2	11257119
Pubmed	Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion.	TRPC7 TRPC6	3.08e-04	9	103	2	17480026
Pubmed	TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.	MEFV NOD2	3.08e-04	9	103	2	22829933
Pubmed	Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.	COX4I1 ALKBH5 MRPS30 FAM120A UBXN7	3.47e-04	202	103	5	29540532
Pubmed	Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.	SETD1A HCFC1	3.85e-04	10	103	2	17998332
Pubmed	Heterogeneous distribution of TRPC proteins in the embryonic cortex.	TRPC7 TRPC6	3.85e-04	10	103	2	18989690
Pubmed	The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.	PARD6G PARD6A	3.85e-04	10	103	2	10934474
Pubmed	Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.	SETD1A HCFC1	3.85e-04	10	103	2	18838538
Pubmed	The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.	TRPC7 TRPC6	3.85e-04	10	103	2	27177420
Pubmed	Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK.	CACNA1B PPFIA1	3.85e-04	10	103	2	18054859
Pubmed	Enhancer activation requires trans-recruitment of a mega transcription factor complex.	NCOR2 PRKDC	3.85e-04	10	103	2	25303530
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	U2AF2 NCOR2 ARID1B PRKDC HCFC1	5.12e-04	220	103	5	35785414
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	U2AF2 XAB2 ARID1B UBXN7 HCFC1 ZNF687	5.31e-04	339	103	6	30415952
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	SETD1A XAB2 ARID1B UBXN7 HCFC1 ZNF687	5.47e-04	341	103	6	32971831
Pubmed	LncRNA DUXAP9-206 directly binds with Cbl-b to augment EGFR signaling and promotes non-small cell lung cancer progression.	SRMS CBLB	5.62e-04	12	103	2	30515972
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	SETD1A HCFC1	5.62e-04	12	103	2	27563068
Pubmed	hCOA3 stabilizes cytochrome c oxidase 1 (COX1) and promotes cytochrome c oxidase assembly in human mitochondria.	COX4I1 NDUFV1	5.62e-04	12	103	2	23362268
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	ARID1B ANKRD11 PRKDC HCFC1	5.84e-04	128	103	4	23858473
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	PPFIA1 PCLO CUL7 NCOR2 FAM120A CCDC87 PRKDC AGRN	6.40e-04	639	103	8	23443559
Pubmed	A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells.	PARD6G PARD6A	6.63e-04	13	103	2	17057644
Pubmed	Melanopsin signalling in mammalian iris and retina.	TRPC7 TRPC6	6.63e-04	13	103	2	22051675
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	SETD1A XAB2 ARID1B HCFC1	6.93e-04	134	103	4	25452129
Interaction	PCDHA10 interactions	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	7.16e-16	22	102	9	int:PCDHA10
Interaction	PCDHA7 interactions	PCDHA12 PCDHA8 PCDHA7 PCDHA4 PCDHA2	5.81e-09	14	102	5	int:PCDHA7
Interaction	PCDHA8 interactions	PCDHA12 PCDHA8 PCDHA7 PCDHA6 PCDHA4 PCDHA3 PCDHA2	1.15e-08	55	102	7	int:PCDHA8
Interaction	FLT3 interactions	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 CBLB FIZ1 PRKDC	7.36e-08	318	102	12	int:FLT3
Interaction	PCDHA1 interactions	PCDHA11 PCDHA8 PCDHA4 PCDHA3	7.64e-08	9	102	4	int:PCDHA1
Interaction	PCDHGA10 interactions	PCDHA12 PCDHA11 PCDHA8 PCDHA4	2.26e-06	19	102	4	int:PCDHGA10
Interaction	PCDHA11 interactions	PCDHA12 PCDHA11 PCDHA4 PCDHA3	2.26e-06	19	102	4	int:PCDHA11
Interaction	PCDHA12 interactions	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA4	3.50e-06	46	102	5	int:PCDHA12
Interaction	PCDHA6 interactions	PCDHA8 PCDHA6 PCDHA3	1.03e-05	9	102	3	int:PCDHA6
Interaction	PCDHA4 interactions	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA4	1.32e-05	60	102	5	int:PCDHA4
Interaction	LONP2 interactions	PCDHA12 PCDHA11 PCDHA8 PCDHA4 PCDHA3	1.55e-05	62	102	5	int:LONP2
Interaction	PCDHA9 interactions	PCDHA11 PCDHA7 PCDHA4 PCDHA3	1.99e-05	32	102	4	int:PCDHA9
Interaction	PCDHA3 interactions	PCDHA11 PCDHA8 PCDHA6 PCDHA3	2.55e-05	34	102	4	int:PCDHA3
Interaction	PCDHA2 interactions	PCDHA8 PCDHA7 PCDHA2	4.40e-05	14	102	3	int:PCDHA2
Interaction	DCAF8L1 interactions	CUL7 DCAF8L1	7.58e-05	3	102	2	int:DCAF8L1
Cytoband	5q31	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	5.82e-12	115	103	9	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	TRPC7 PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	1.58e-09	298	103	10	chr5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	RPS6KA4 PPFIA1 MUS81 NDUFV1 CCDC87 SAC3D1	5.77e-04	454	103	6	chr11q13
GeneFamily	Clustered protocadherins	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	5.75e-12	64	76	9	20
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF805 ZIM2 ZNF232 ZBTB14 IKZF5 ZNF546 ZSCAN29 ZBTB34 FIZ1 ZNF398 ZNF747 ZNF574	4.22e-05	718	76	12	28
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM2 PRDM13	2.28e-03	17	76	2	1197
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	7.89e-07	261	101	9	MM1277
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED	PCDHA12 PCDHA11 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	4.02e-06	238	101	8	M2020
Coexpression	GSE11961_MARGINAL_ZONE_BCELL_VS_GERMINAL_CENTER_BCELL_DAY40_UP	PPFIA1 TRPC6 PARD6G ARID1B ANGPTL4 ACAA2 MPPED2	1.27e-05	200	101	7	M9317
Drug	Acebutolol hydrochloride [34381-68-5]; Up 200; 10.8uM; MCF7; HT_HG-U133A	SETD1A U2AF2 CUL7 CEMIP ZNF747 CD70 ACAA2 CABIN1 HCFC1	2.70e-07	198	102	9	1493_UP
Drug	Sulfaguanidine [57-67-0]; Up 200; 18.6uM; MCF7; HT_HG-U133A	PCLO PCDHA6 TUT1 CUL7 PRDM2 SPTBN5 AP1G2 AGAP2	3.10e-06	198	102	8	4839_UP
Disease	1,5 anhydroglucitol measurement	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	3.86e-16	29	100	9	EFO_0008009
Disease	visceral adipose tissue measurement, body mass index	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	1.68e-11	87	100	9	EFO_0004340, EFO_0004765
Disease	post-traumatic stress disorder symptom measurement	PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	1.28e-08	82	100	7	EFO_0008535
Disease	neutrophil count, basophil count	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	7.45e-08	224	100	9	EFO_0004833, EFO_0005090
Disease	post-traumatic stress disorder	PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 FAM120A	4.56e-07	202	100	8	EFO_0001358
Disease	vital capacity	DIS3L2 AOC1 PCLO PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 GFPT1 NCOR2 UBXN7 MPPED2 PLXNA1	8.39e-07	1236	100	17	EFO_0004312
Disease	neuroticism measurement, cognitive function measurement	PCLO PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 FAM120A	3.56e-06	566	100	11	EFO_0007660, EFO_0008354
Disease	neutrophil count	COX4I1 RC3H1 MUS81 PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 CEPT1 ERAP2 ANKRD11 ZNF398 PRKDC	3.80e-06	1382	100	17	EFO_0004833
Disease	Acne Vulgaris	MEFV NOD2	6.79e-05	4	100	2	C0001144
Disease	Acne	MEFV NOD2	6.79e-05	4	100	2	C0702166
Disease	Pyoderma Gangrenosum	MEFV NOD2	6.79e-05	4	100	2	C0085652
Disease	Abnormality of refraction	PCLO PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2	9.76e-05	673	100	10	HP_0000539
Disease	Hidradenitis Suppurativa	MEFV NOD2	2.36e-04	7	100	2	C0162836
Disease	pulse pressure measurement	PCDHA12 PCDHA11 PCDHA8 PCDHA7 PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 SLC39A10 ARID1B ANKRD11 MPPED2 HCFC1	2.51e-04	1392	100	14	EFO_0005763
Disease	familial Mediterranean fever (is_implicated_in)	MEFV NOD2	4.03e-04	9	100	2	DOID:2987 (is_implicated_in)
Disease	depressive symptom measurement	PCLO PCDHA6 PCDHA5 PCDHA4 PCDHA3 PCDHA2 FAM120A	6.29e-04	426	100	7	EFO_0007006
Disease	nicotine dependence (implicated_via_orthology)	TRPC7 TRPC6	7.34e-04	12	100	2	DOID:0050742 (implicated_via_orthology)
Disease	Arthritis, Psoriatic	MEFV NOD2	1.01e-03	14	100	2	C0003872
Disease	Myasthenic Syndromes, Congenital, Slow Channel	GFPT1 AGRN	1.32e-03	16	100	2	C0751885
Disease	Congenital Myasthenic Syndromes, Postsynaptic	GFPT1 AGRN	1.50e-03	17	100	2	C0751883
Disease	dehydroepiandrosterone sulphate measurement	ABCA13 TRPC6 TECRL	1.61e-03	68	100	3	EFO_0007001
Disease	Congenital Myasthenic Syndromes, Presynaptic	GFPT1 AGRN	1.87e-03	19	100	2	C0751884
Disease	ulcerative colitis, Crohn's disease	NOD2 NCOR2	2.08e-03	20	100	2	EFO_0000384, EFO_0000729
Disease	Deaf Mutism	GJB3 OTOF	2.08e-03	20	100	2	C4082305
Disease	Deafness, Acquired	GJB3 OTOF	2.08e-03	20	100	2	C0751068
Disease	Hearing Loss, Extreme	GJB3 OTOF	2.08e-03	20	100	2	C0086395
Disease	Complete Hearing Loss	GJB3 OTOF	2.08e-03	20	100	2	C0581883
Disease	Prelingual Deafness	GJB3 OTOF	2.08e-03	20	100	2	C0011052
Disease	Bilateral Deafness	GJB3 OTOF	2.08e-03	20	100	2	C3665473
Disease	Self-injurious behavior	PCDHA4 SPTBN5 ARID1B	2.39e-03	78	100	3	HP_0100716
Disease	Myasthenic Syndromes, Congenital	GFPT1 AGRN	2.99e-03	24	100	2	C0751882
Disease	Deafness	GJB3 OTOF	3.24e-03	25	100	2	C0011053

Protein segments in the cluster

Peptide	Gene	Start	Entry
HLDHEVAKPARRKRL	ANGPTL4	151	Q9BY76
ELLRHHRDEQKPATR	ANKRD11	1491	Q6UB99
HRKADPDAAHRPRIL	ALKBH5	326	Q6P6C2
AVRRALGKHRLHLIP	ASB1	306	Q9Y576
RDVVVGRHPLHLLED	AGRN	2041	O00468
DGDPVHRHRQLAKLL	AP1G2	41	O75843
IPLRERHVKGRVDPH	CGB1	11	A6NKQ9
IRRLHLEAHADKPVA	ABCA13	4841	Q86UQ4
PGKKRHERLFHRQDA	AGAP2	61	Q99490
GKLILLHHEHPERKR	ARID1B	2046	Q8NFD5
RVLARHDLLPHLARK	DEDD2	91	Q8WXF8
HDLLPHLARKRRRPV	DEDD2	96	Q8WXF8
HVLRFLDKGERHPVR	AOC1	81	P19801
TRHPAAGHRLEELEK	CCDC87	386	Q9NVE4
KIHRAFPEQALLRRH	DIS3L2	596	Q8IYB7
DPPRRHHRHRDKDKT	CACNA1B	846	Q00975
KDHDEPIVLRTRHIL	CEMIP	86	Q8WUJ3
LHGPELDKGQLRIHR	CD70	86	P32970
QPHPSLDELHRRRKE	RC3H1	746	Q5TC82
DSPRHRLLVLVKDHG	PCDHA2	641	Q9Y5H9
DSPRHRLLVLVKDHG	PCDHA6	641	Q9UN73
DAPRHRLLVLVKDHG	PCDHA7	641	Q9UN72
RPRHGHRAVAIKELI	HCFC1	31	P51610
RRVRPKLHVFGGIHE	MPPED2	241	Q15777
AGRSIHEIPREELRH	NCOR2	1421	Q9Y618
SPRHRLLVLVKDHGE	PCDHA11	641	Q9Y5I1
RELHRRRKLDPGKMH	C20orf96	81	Q9NUD7
DSPRHRLLVLVKDHG	PCDHA8	641	Q9Y5H6
DAPRHRLLVLVKDHG	PCDHA3	641	Q9Y5H8
RVGSDPVLMRKHRRH	CBLB	631	Q13191
GHGLDRKLPERLVHS	PCLO	4456	Q9Y6V0
LRLDDLFKLGEPHHR	PLXNA1	141	Q9UIW2
PEEHKHTRRQLEDIR	OPTC	291	Q9UBM4
LHLLGKGTLRRHDDR	CUL7	1626	Q14999
RGEFLAPPRHHKRED	LMO7	231	Q8WWI1
PRALRLDRLHKGALH	PPFIA1	746	Q13136
PFRNERGKGKIRHHI	EXPH5	966	Q8NEV8
LGPHVEGLKAEERHR	MSLN	551	Q13421
LRGGELLEHIRKKRH	RPS6KA4	486	O75676
GHRVRPIEEVALEHK	MEFV	406	O15553
EERGHPLHPRHRKAV	C6orf223	81	Q8N319
VAPEVLRVAEHRHKK	FAM120A	551	Q9NZB2
APRHRLLVLVKDHGE	PCDHA5	641	Q9Y5H7
RLIEHIRIHTGEKPH	IKZF5	96	Q9H5V7
HRRVRLHRHGCEKPL	PARD6G	156	Q9BYG4
RRVRLHKHGSDRPLG	PARD6A	156	Q9NPB6
DAPRHRLLVLVKDHG	PCDHA4	641	Q9UN74
PPLSRHQLKRLEEHR	CEPT1	41	Q9Y6K0
GHVALRLIRIPLARH	CABIN1	131	Q9Y6J0
PAHGKEVRQLRHLHR	LINC00315	56	P59091
PEGREAHKHGLAALR	ELK3	116	P41970
PRDLERHVLVHTGEK	FIZ1	426	Q96SL8
HTLLRPKDRVGLIHD	ERAP2	651	Q6P179
RVAKHRGPAHELALE	DCAF8L1	281	A6NGE4
EQRHLPRVAGHIKKR	SDR42E2	216	A6NKP2
REGRILPKRIHLRAE	CCDC168	4891	Q8NDH2
CHRVLRGLHKDKPRG	GJB3	211	O75712
RRDHPLPEVAHVKHL	COX4I1	41	P13073
RRRDLERHVKSRHPG	PRDM13	641	Q9H4Q3
KARRVPAHGHPVIER	UTP3	286	Q9NQZ2
REHRLHRLEVVPGCR	SAC3D1	71	A6NKF1
NEGELRHTRKREAPH	SLC39A10	301	Q9ULF5
AVRKHAKGLHIVPRL	CHID1	136	Q9BWS9
THPRIDPDVIHRLRK	HS3ST4	416	Q9Y661
LHIPLKHLERRDAES	MOCS3	371	O95396
RRHERRHEAGLKRKP	PRDM2	406	Q13029
HQRRVHERHLIPKGV	PRDM2	501	Q13029
RKPTDEHVALLALRH	OTOF	1656	Q9HC10
DAPRHRLLVLVKDHG	PCDHA12	641	Q9UN75
SILKRSRPEHHRPEA	NRAC	46	Q8N912
HTQFHLLPDKLRRER	MRPS30	296	Q9NP92
HKRVALHQGRPREII	XAB2	361	Q9HCS7
RLSIHRIKRTAGDHP	GFPT1	306	Q06210
EKRPEEVALGLHHRL	CCDC51	46	Q96ER9
KDREILRHDPHKLLE	NDUFV1	126	P49821
KRSEHREPRLNEKLH	SLC9A3	466	P48764
TLKGLRHERLIRLHA	SRMS	276	Q9H3Y6
LLHPRTRKHLGLARV	SETD1A	126	O15047
RLLRKHEELEREVHP	SPTBN5	2401	Q9NRC6
RRLKVEGHRFPRTIH	ACY1	126	Q03154
ITAHLVHELRRRGGK	ACAA2	361	P42765
LKDHERRHRGEKPFV	ZBTB14	376	O43829
LRKRHHEPGVADRLI	NOD2	456	Q9HC29
GGRKHRHLVELRAAR	TUT1	36	Q9H6E5
KVEIHSRRLLHLEGR	ZNF398	56	Q8TD17
LKDHRRLHTGERPFA	ZNF574	781	Q6ZN55
KHRAIHRGERPHRCP	ZNF747	226	Q9BV97
KLKRRRVSLVLPEHH	SPDYE1	141	Q8NFV5
LRARRKGGAPVHVRH	TRIL	726	Q7L0X0
AELARHRRIHTGEKP	ZNF546	426	Q86UE3
RKLEGKPLRFRGVHH	SLC25A27	161	O95847
ARHPRVKRDKAVHER	SLC6A11	36	P48066
KRIIIRGHDEREHPF	PRKDC	3736	P78527
VALRRHERIHTGKKP	ZIM2	341	Q9NZV7
EEHGGLIRSPRHEKK	U2AF2	71	P26368
PHKDLGHRKEENRRP	UBXN7	351	O94888
SELIRHRRVHARKEP	ZNF232	401	Q9UNY5
PSLRRHVRVNHEGIK	ZNF687	1006	Q8N1G0
GKESARRLRHPVVHL	TECRL	171	Q5HYJ1
HTLLRKGARIERPHD	TRPC6	236	Q9Y210
ARLIRHRRIHTGEKP	ZSCAN29	691	Q8IWY8
RLLARHERIHSGVKP	ZNF805	216	Q5CZA5
KKRHIDLRRPHRQEL	ZAR1L	286	A6NP61
HLRKNHPGVAEVRSR	ZBTB34	446	Q8NCN2
HILLLKGARIERPHD	TRPC7	181	Q9HCX4
RDEHLLKRRNVPHED	KPNA4	41	O00629
GGHRPELLRELQRLH	MUS81	281	Q96NY9