Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmicrofilament motor activity

MYO1C MYO6 MYO1H MYO15A

1.75e-0538824GO:0000146
GeneOntologyMolecularFunctionselenocysteine insertion sequence binding

SECISBP2L EIF4A3

2.47e-046822GO:0035368
GeneOntologyCellularComponentmyosin complex

MYO1C MYO6 MYO1H MYO15A

8.91e-0559834GO:0016459
GeneOntologyCellularComponentSec61 translocon complex

SEC61A2 SEC61A1

1.55e-045832GO:0005784
GeneOntologyCellularComponenttranslocon complex

SEC61A2 SEC61A1

2.31e-046832GO:0071256
GeneOntologyCellularComponentlysosomal membrane

GPR155 ATP6V1C1 AP2B1 MYO6 LRP1 DEPDC5 SLC66A1 RHEB

4.96e-04462838GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

GPR155 ATP6V1C1 AP2B1 MYO6 LRP1 DEPDC5 SLC66A1 RHEB

4.96e-04462838GO:0098852
GeneOntologyCellularComponentbasal part of cell

SLC2A9 MYO1C TJP1 DOCK7 LRP1 TSHR ITGB4

7.64e-04378837GO:0045178
GeneOntologyCellularComponentunconventional myosin complex

MYO1C MYO6

8.37e-0411832GO:0016461
GeneOntologyCellularComponentvacuolar membrane

GPR155 ATP6V1C1 AP2B1 MYO6 LRP1 DEPDC5 SLC66A1 RHEB

9.09e-04507838GO:0005774
MousePhenoabnormal tectorial membrane morphology

COL11A2 MYO6 TSHR MYO15A

1.76e-0532694MP:0003149
MousePhenoimpaired swimming

DOCK3 MYO6 CNTNAP1 MYO15A LYST

4.56e-0580695MP:0001522
DomainDOCK_C

DOCK3 DOCK7 DOCK10

1.36e-0511833IPR010703
DomainDHR-1_domain

DOCK3 DOCK7 DOCK10

1.36e-0511833IPR027007
DomainDHR_2

DOCK3 DOCK7 DOCK10

1.36e-0511833PS51651
DomainDHR_1

DOCK3 DOCK7 DOCK10

1.36e-0511833PS51650
DomainDOCK-C2

DOCK3 DOCK7 DOCK10

1.36e-0511833PF14429
DomainDHR-2

DOCK3 DOCK7 DOCK10

1.36e-0511833IPR027357
DomainDHR-2

DOCK3 DOCK7 DOCK10

1.36e-0511833PF06920
DomainDOCK

DOCK3 DOCK7 DOCK10

1.36e-0511833IPR026791
DomainPlug_translocon

SEC61A2 SEC61A1

1.95e-052832PF10559
DomainSecY_su_dom

SEC61A2 SEC61A1

1.95e-052832IPR023201
DomainCell_morpho_N

FRY FRYL

1.95e-052832IPR025614
DomainSecY

SEC61A2 SEC61A1

1.95e-052832PF00344
DomainSECY_1

SEC61A2 SEC61A1

1.95e-052832PS00755
DomainSECY_2

SEC61A2 SEC61A1

1.95e-052832PS00756
DomainMOR2-PAG1_mid

FRY FRYL

1.95e-052832IPR029473
Domain-

SEC61A2 SEC61A1

1.95e-0528321.10.3370.10
DomainTranslocon_Sec61/SecY_plug_dom

SEC61A2 SEC61A1

1.95e-052832IPR019561
DomainMOR2-PAG1_mid

FRY FRYL

1.95e-052832PF14228
DomainMOR2-PAG1_C

FRY FRYL

1.95e-052832PF14225
DomainMOR2-PAG1_N

FRY FRYL

1.95e-052832PF14222
DomainSecY_CS

SEC61A2 SEC61A1

1.95e-052832IPR030659
DomainCell_Morphogen_C

FRY FRYL

1.95e-052832IPR025481
DomainSecY/SEC61-alpha

SEC61A2 SEC61A1

1.95e-052832IPR002208
DomainEYA_fam

EYA4 EYA3

1.16e-044832IPR028472
DomainEYA_dom

EYA4 EYA3

1.16e-044832IPR006545
DomainDUF3398

DOCK7 DOCK10

2.89e-046832PF11878
DomainDOCK_C/D_N

DOCK7 DOCK10

2.89e-046832IPR021816
DomainMyosin_head_motor_dom

MYO1C MYO6 MYO15A

6.38e-0438833IPR001609
DomainMYOSIN_MOTOR

MYO1C MYO6 MYO15A

6.38e-0438833PS51456
DomainMyosin_head

MYO1C MYO6 MYO15A

6.38e-0438833PF00063
DomainMYSc

MYO1C MYO6 MYO15A

6.38e-0438833SM00242
DomainCalx_beta

ITGB4 FREM1

6.88e-049832IPR003644
DomainCalx-beta

ITGB4 FREM1

6.88e-049832PF03160
DomainLY

LRP1 ROS1

1.97e-0315832SM00135
DomainLDLR_classB_rpt

LRP1 ROS1

1.97e-0315832IPR000033
DomainIQ

MYO1C MYO6 MYO15A

3.89e-0371833PF00612
DomainDEP

GPR155 DEPDC5

4.25e-0322832PF00610
DomainDEP

GPR155 DEPDC5

4.25e-0322832PS50186
DomainDEP

GPR155 DEPDC5

4.25e-0322832SM00049
DomainDEP_dom

GPR155 DEPDC5

4.65e-0323832IPR000591
DomainIQ

MYO1C MYO6 MYO15A

5.63e-0381833SM00015
Pubmed

Myosins: a diverse superfamily.

MYO1C MYO6 MYO15A

4.72e-07784310722873
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

DOCK3 ZBTB44 FRY AP2B1 SACS MYO6 TJP1 EIF4A3 CNTNAP1 LRP1 EYA3 ZNF606 PLEKHB1 TDP2

2.33e-061285841435914814
Pubmed

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

DOCK3 DOCK7 DOCK10

4.85e-061484312432077
Pubmed

Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.

SEC61A2 SEC61A1

5.76e-06284218480044
Pubmed

Phospholipid metabolism-related genotypes of PLA2R1 and CERS4 contribute to nonobese MASLD.

PLA2R1 CERS4

5.76e-06284238836837
Pubmed

Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells.

MYO6 DOCK7

5.76e-06284227018747
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

MYO1C MYO6 CNTNAP1 DOCK7 FRYL ITGB4

9.94e-0620284633005030
Pubmed

LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking.

LRP1 LDLRAD3

1.73e-05384221795536
Pubmed

Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51.

MYO6 TJP1

1.73e-05384220602916
Pubmed

PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa.

MYO1C PLEKHB1

1.73e-05384215976448
Pubmed

Novel myosin mutations for hereditary hearing loss revealed by targeted genomic capture and massively parallel sequencing.

MYO6 MYO15A

1.73e-05384224105371
Pubmed

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.

AP2B1 MYO6 DOCK7

2.02e-052284326950368
Pubmed

Genetic Hearing Loss Overview

EYA4 COL11A2 MYO6 MYO15A

2.57e-057084420301607
Pubmed

FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes.

TJP1 ITGB4

3.45e-05484223977053
Pubmed

Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness.

EYA4 COL11A2

3.45e-05484227142990
Pubmed

Next-generation sequencing of small RNAs from inner ear sensory epithelium identifies microRNAs and defines regulatory pathways.

MYO6 TJP1

3.45e-05484224942165
Pubmed

Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes.

MYO6 MYO15A

3.45e-05484222105175
Pubmed

Myo15 function is distinct from Myo6, Myo7a and pirouette genes in development of cochlear stereocilia.

MYO6 MYO15A

3.45e-05484212966030
Pubmed

Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis.

EYA4 EYA3

3.45e-05484219901965
Pubmed

The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment.

SEC61A2 SEC61A1

3.45e-05484210212142
Pubmed

Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane.

MYO1C TJP1

3.45e-05484221402783
Pubmed

The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function.

DEPDC5 RHEB

5.74e-05584238411613
Pubmed

Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex.

SEC61A2 SEC61A1

5.74e-0558429565615
Pubmed

Genomics and hearing impairment.

MYO6 MYO15A

8.59e-0568429927480
Pubmed

Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress.

SEC61A2 SEC61A1

8.59e-05684216705175
Pubmed

EYA4, a novel vertebrate gene related to Drosophila eyes absent.

EYA4 EYA3

8.59e-0568429887327
Pubmed

Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes.

TAF10 TRRAP

8.59e-05684215115762
Pubmed

A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes.

DNAJC1 SEC61A1

8.59e-05684212065409
Pubmed

mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.

MYO1C TJP1 ANKRD12 ALOX12B

9.62e-059884434943047
Pubmed

Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.

MYO1C AP2B1 MYO6 TJP1 DOCK7

1.03e-0419184533762435
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

PLA2R1 LRP1 TSHR ITGB4

1.08e-0410184423382219
Pubmed

Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse.

MYO6 MYO15A

1.20e-04784216962269
Pubmed

Tails of unconventional myosins.

MYO6 MYO15A

1.20e-04784211212352
Pubmed

Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.

ITGB4 ALOX12B

1.20e-04784210727209
Pubmed

Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum.

DNAJC1 SEC61A1

1.20e-04784226085089
Pubmed

Helios is a key transcriptional regulator of outer hair cell maturation.

MYO6 MYO15A

1.20e-04784230464345
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

SEC61A2 COL11A2 MYO1C AP2B1 MYO6 TJP1 DOCK7 LRP1 TRRAP SEC61A1

1.55e-041005841019615732
Pubmed

FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.

FRMD4A TJP1

1.60e-04884220080746
Pubmed

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

AP2B1 MYO6 MYO15A

1.68e-044484327534441
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MYO1C AP2B1 TJP1 AHCTF1 DOCK7 RBM6 FRYL TRRAP

1.84e-0465384822586326
Pubmed

TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.

SEC61A2 MYO1C SEC61A1 ALOX12B

1.91e-0411784436898370
Pubmed

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.

MYO1C AP2B1 DOCK7 ITGB4

1.97e-0411884430979931
Pubmed

beta-Catenin protects the epidermis from mechanical stresses.

TJP1 ITGB4

2.05e-04984223816618
Pubmed

A genome-wide association study of serum uric acid in African Americans.

SLC2A9 TSHR

2.05e-04984221294900
Pubmed

The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.

TJP1 ITGB4

2.05e-04984221074722
Pubmed

Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.

MYO1C MYO15A

2.05e-04984219339464
Pubmed

The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners.

TAF10 TRRAP

2.56e-041084215870280
Pubmed

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression.

TAF10 TRRAP

2.56e-041084218206973
Pubmed

Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates.

TAF10 TRRAP

2.56e-04108429880483
Pubmed

Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease.

PSMA2 LYST

2.56e-041084212446740
Pubmed

Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation.

TAF10 TRRAP

2.56e-041084217694077
Pubmed

CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues.

NFYC TAF10

3.13e-04118429153318
Pubmed

The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.

TAF10 TRRAP

3.13e-04118429885574
Pubmed

Semaphorin-5B Controls Spiral Ganglion Neuron Branch Refinement during Development.

SEMA5B MYO6

3.13e-041184231209173
Pubmed

Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage.

TAF10 TRRAP

3.13e-041184218250150
Pubmed

Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.

DOCK3 MYO1C TJP1

3.43e-045684322745667
Pubmed

Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath.

CNTNAP1 ITGB4

3.75e-041284218579745
Pubmed

The role of assembly in insulin's biosynthesis.

SEC61A2 SEC61A1

3.75e-04128429631292
Pubmed

Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles.

TJP1 ITGB4

4.42e-041384218849982
Pubmed

CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.

GPR3 DOCK7 TSHR RHEB

4.43e-0414684429688375
Pubmed

RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma.

MYO1C MYO6 ALOX12B

4.64e-046284335568845
Pubmed

Identification of a small TAF complex and its role in the assembly of TAF-containing complexes.

TAF10 TRRAP

5.15e-041484217375202
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

SACS LRP1

5.15e-041484215082773
Pubmed

EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation.

TJP1 ITGB4

5.15e-041484221949412
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

EYA4 RASGEF1B DOCK10 LRP1 DAZL KRTAP15-1

5.50e-0442084628065597
Pubmed

WDFY4 is required for cross-presentation in response to viral and tumor antigens.

MYO1C AP2B1 MYO6 SEC61A1

5.69e-0415684430409884
Pubmed

RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.

TJP1 MYO15A

5.93e-041584236260679
Pubmed

Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.

TAF10 TRRAP

5.93e-041584212601814
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

TJP1 PSMA2 AHCTF1 CNTNAP1 DOCK7 TMEM209 LRP1 DNAJC1 SEC61A1 TDP2

6.41e-041203841029180619
Pubmed

Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR.

MYO1C AP2B1 MYO6 EIF4A3 DOCK7

6.92e-0428984537132043
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SEC61A2 MYO1C AP2B1 SACS TJP1 EIF4A3 PSMA2 PCLO SPAG17 SEC61A1 LYST

6.93e-041442841135575683
Pubmed

Histone-like TAFs within the PCAF histone acetylase complex.

TAF10 TRRAP

7.66e-04178429674425
Pubmed

Chromosomal locations of the mouse fatty acid oxidation genes Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene.

EYA3 CRAT

7.66e-04178429680378
Pubmed

Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women.

CNTNAP1 ALOX12B

7.66e-041784219372141
Pubmed

Desmoplakin is essential in epidermal sheet formation.

TJP1 ITGB4

7.66e-041784211781569
Pubmed

A germline-specific class of small RNAs binds mammalian Piwi proteins.

TMEM209 LRP1 DAZL ANKRD12 EYA3 SLC66A1

7.88e-0445084616751776
Pubmed

Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles.

EYA4 TJP1

8.60e-041884229229865
Pubmed

Identification of genes concordantly expressed with Atoh1 during inner ear development.

MYO6 MYO15A

9.60e-041984221519551
Pubmed

Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development.

TJP1 ITGB4

9.60e-041984232582689
Pubmed

Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice.

MYO1C MYO6

9.60e-041984232888949
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

MYO1C MYO6 PSMA2 TAF10 SEC61A1 ITGB4 ALOX12B

9.81e-0464784726618866
Pubmed

UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation.

TAF10 TRRAP

1.06e-032084211406595
Pubmed

Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module.

TAF10 TRRAP

1.06e-032084227601583
Pubmed

Function of TAF(II)-containing complex without TBP in transcription by RNA polymerase II.

TAF10 TRRAP

1.06e-03208429603525
Pubmed

Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.

TAF10 TRRAP

1.06e-032084210373431
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

MYO1C AP2B1 MYO6 TJP1 EIF4A3 DOCK7 NFYC

1.10e-0366084732780723
Pubmed

Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.

TJP1 TSHR

1.17e-032184223707896
Pubmed

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.

ITGB4 FREM1

1.17e-032184227856617
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FRMD4A PCLO FRYL

1.24e-038784312465718
Pubmed

An approach based on a genome-wide association study reveals candidate loci for narcolepsy.

HIPK3 PCLO CRAT TDP2

1.25e-0319384420677014
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SECISBP2L DOCK3 SACS MYO6 ZNF606 TBC1D9

1.26e-0349384615368895
Pubmed

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.

SEC61A2 TJP1 PSMA2 SEC61A1

1.30e-0319584417110338
Pubmed

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

MYO6 HTR3B

1.41e-032384225217961
Pubmed

The small GTPase Rac1 regulates auditory hair cell morphogenesis.

MYO6 MYO15A

1.41e-032384220016102
Pubmed

New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity.

TJP1 ITGB4

1.41e-032384218809908
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

MYO1C MYO6 AHCTF1 DOCK7 TAF10 TRRAP

1.44e-0350684630890647
Pubmed

Par3 is essential for the establishment of planar cell polarity of inner ear hair cells.

MYO6 TJP1

1.54e-032484230814219
Pubmed

Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.

TJP1 ITGB4

1.54e-032484224043783
Pubmed

Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice.

FAM168A PLEKHB1

1.54e-032484219706712
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

MYO1C DOCK7 DOCK10 SEC61A1

1.65e-0320884433230847
GeneFamilyEYA transcriptional coactivator and phosphatases

EYA4 EYA3

5.84e-0545721044
GeneFamilyMyosins, class I

MYO1C MYO1H

2.70e-0485721097
GeneFamilyBeta 4-glycosyltransferases

CHSY3 B4GALT6

1.29e-0317572425
GeneFamilyLysine acetyltransferases|ATAC complex|SAGA complex|GCN5 related N-acetyltransferases

TAF10 TRRAP

1.29e-03175721059
CoexpressionGSE20198_UNTREATED_VS_IFNA_TREATED_ACT_CD4_TCELL_UP

GPR155 FRMD4A COL11A2 RASGEF1B NFYC CRAT SLC66A1

3.74e-06200847M7366
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#5_top-relative-expression-ranked_1000

ZBTB44 PLA2R1 ATP6V1C1 SACS ANKRD12 CERS4 HSF5

2.81e-05230817gudmap_developingGonad_e18.5_ovary_1000_k5
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000

SEC61A2 ZBTB44 PLA2R1 SEMA5B SACS DEPDC5 DAZL ANKRD12 DNAJC1 SEC61A1 CERS4 HSF5

4.60e-057958112gudmap_developingGonad_e16.5_ovary_1000
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRY EYA4 EYA3 SPAG17 FREM1 TBC1D9

1.30e-06183846b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCellCOVID-19-lung-Macrophage_PPARGhi_CD5Lhi|lung / Disease (COVID-19 only), tissue and cell type

FRMD4A SLC2A9 SLC22A15 DOCK10 LRP1 LDLRAD3

1.67e-06191846dab953682b8c9ed680a799161f837f792a7e4f33
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK3 CNTN3 ROS1 DMBT1 MYO15A

8.16e-0614584596712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellfacs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARPP21 NRAP JMJD7 SEMA5B PLCH2

9.01e-061488455983c4546f527a0b599cfcbd8a6cb937a1d6f895
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRY EYA4 SPAG17 FREM1 TBC1D9

2.38e-05181845aa233b652921848af2257cc3687a7a09c3acfb67
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO ROS1 MYO15A SPAG17 FREM1

2.57e-051848452cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO ROS1 MYO15A SPAG17 FREM1

2.57e-05184845ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO ROS1 MYO15A SPAG17 FREM1

2.57e-051848452b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

AHCTF1 DOCK10 PDP2 FRYL B4GALT6

2.64e-05185845a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

AHCTF1 DOCK10 PDP2 FRYL B4GALT6

2.71e-051868458571956890fc9894d766ba294a28e376b4aba428
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EYA4 DOCK7 EYA3 FREM1 TBC1D9

2.85e-0518884558ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

GPR155 FRMD4A MYO6 LDLRAD3 FREM1

2.85e-05188845b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC2A9 LRP1 P4HA3 LDLRAD3 CERS4

2.93e-05189845f7d57723b8fb0f1e1485f51e3eff93ec0f39761e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRY DOCK7 EYA3 FREM1 TBC1D9

2.93e-051898458ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EYA4 MYO6 DOCK7 EYA3 FREM1

2.93e-05189845532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRY DOCK7 EYA3 FREM1 TBC1D9

3.00e-051908454836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

AHCTF1 DOCK10 FRYL LYST B4GALT6

3.08e-051918459454f642c3621370fa23640b631301346b300950
ToppCellASK454-Epithelial-Secretory|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

ZBTB44 RBM6 EYA3 PLEKHB1 SLC66A1

3.08e-05191845c63c781e7e93265e591cf494cb4ce8ed797c24fb
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR3 PLCH2 FRYL PLEKHB1 ITGB4

3.08e-051918458691eba35793e4e90f93d50c2145847ee51289f7
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D122|Adult / Lineage, Cell type, age group and donor

FRMD4A SLC2A9 SLC22A15 LRP1 LDLRAD3

3.23e-05193845cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EYA4 MYO6 ITGB4 FREM1 TBC1D9

3.32e-051948454579b4a44f7c731553a284843c296866027d7c0e
ToppCellChildren_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

FRMD4A SLC2A9 RASGEF1B LRP1 LDLRAD3

3.32e-0519484569cf7c989ac355c459db13f9d4267b55adc3c174
ToppCellChildren_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FRMD4A SLC22A15 RASGEF1B LRP1 LDLRAD3

3.40e-051958459d649ac7d2af313481069c95349efc0c68449e2b
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)|Adult / Lineage, Cell type, age group and donor

FRMD4A SLC2A9 DOCK10 LRP1 LDLRAD3

3.40e-0519584555e25f702af19146a161861cfd15f40bbda1dc35
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EYA4 MYO6 ITGB4 FREM1 TBC1D9

3.40e-051958453d6d3de8ada6dce3dc789c15b50cc066e7100496
ToppCellAdult-Immune|Adult / Lineage, Cell type, age group and donor

FRMD4A SLC2A9 DOCK10 LRP1 LDLRAD3

3.65e-051988459bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SECISBP2L MYO6 DOCK10 PLEKHB1 ITGB4

3.65e-05198845fef9a4c96450078527b94d25e681410e4ea01b13
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK3 PLA2R1 DMBT1 LDLRAD3 ITGB4

3.83e-05200845030efc36bbb848da31b0db3f74d46aac9c79cc9b
DiseaseDrug habituation

FRMD4A PLA2R1 MYO6 ZNF606 LDLRAD3

1.39e-05115785C0013170
DiseaseSubstance-Related Disorders

FRMD4A PLA2R1 MYO6 ZNF606 LDLRAD3

1.39e-05115785C0236969
DiseaseDrug abuse

FRMD4A PLA2R1 MYO6 ZNF606 LDLRAD3

1.39e-05115785C0013146
DiseaseDrug Use Disorders

FRMD4A PLA2R1 MYO6 ZNF606 LDLRAD3

1.39e-05115785C0013222
DiseaseDrug Dependence

FRMD4A PLA2R1 MYO6 ZNF606 LDLRAD3

1.39e-05115785C1510472
DiseaseSubstance Dependence

FRMD4A PLA2R1 MYO6 ZNF606 LDLRAD3

1.39e-05115785C0038580
DiseaseSubstance Use Disorders

FRMD4A PLA2R1 MYO6 ZNF606 LDLRAD3

1.39e-05115785C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

FRMD4A PLA2R1 MYO6 ZNF606 LDLRAD3

1.39e-05115785C0029231
DiseasePrescription Drug Abuse

FRMD4A PLA2R1 MYO6 ZNF606 LDLRAD3

1.39e-05115785C4316881
DiseaseSubstance abuse problem

FRMD4A PLA2R1 MYO6 ZNF606 LDLRAD3

1.45e-05116785C0740858
DiseaseNonsyndromic genetic hearing loss

EYA4 COL11A2 MYO6 MYO15A

5.02e-0576784cv:C5680182
DiseaseAutosomal dominant nonsyndromic hearing loss

EYA4 COL11A2 MYO6

6.18e-0529783cv:C5779548
DiseaseNonsyndromic Deafness

EYA4 COL11A2 MYO6 MYO15A

6.44e-0581784C3711374
Diseasesensorineural hearing loss (is_implicated_in)

EYA4 MYO6 MYO15A

9.16e-0533783DOID:10003 (is_implicated_in)
Diseaseeye disease (implicated_via_orthology)

EYA4 EYA3

1.03e-046782DOID:5614 (implicated_via_orthology)
Diseasebranchiootorenal syndrome (implicated_via_orthology)

EYA4 EYA3

1.44e-047782DOID:14702 (implicated_via_orthology)
Diseasepulmonary function measurement, smoking behaviour measurement, FEV/FEC ratio

FAM168A LRP1 PLEKHB1

2.65e-0447783EFO_0003892, EFO_0004713, EFO_0005671
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

COL11A2 MYO6 MYO15A

3.38e-0451783cv:CN043650
Diseasecongenital diaphragmatic hernia (implicated_via_orthology)

LRP1 FREM1

4.48e-0412782DOID:3827 (implicated_via_orthology)
DiseaseTesticular Germ Cell Tumor

DAZL ALOX12B

6.15e-0414782C1336708
DiseaseHereditary hearing loss and deafness

EYA4 COL11A2 MYO6 MYO15A

6.18e-04146784cv:C0236038
DiseaseHeadache

MYO1H LRP1 CHSY3

6.59e-0464783HP_0002315
Diseaseplatelet storage pool deficiency (implicated_via_orthology)

DOCK7 LYST

7.08e-0415782DOID:2223 (implicated_via_orthology)
Diseasephosphatidylcholine 38:6 measurement

AHCTF1 DEPDC5

8.08e-0416782EFO_0010388
Diseasethrombin activatable fibrinolysis inhibitor activation peptide measurement

ARPP21 DOCK10

1.15e-0319782EFO_0008582
Diseaseattention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement

ARPP21 NRAP KCNU1 FAM168A DOCK10 CNTN3 DNAJC1 PLEKHB1

1.25e-03801788EFO_0003888, EFO_0007052, MONDO_0002491
Diseaseage-related hearing impairment

EYA4 COL11A2 MYO6 DOCK10 SPAG17

1.70e-03324785EFO_0005782
Diseaseantiphospholipid syndrome

FRMD4A TSHR

1.83e-0324782EFO_0002689
Diseasesmoking behavior

NRAP FAM168A DOCK10 DNAJC1 PLEKHB1

2.12e-03341785EFO_0004318
Diseaseblood rubidium measurement

FRMD4A ATP6V1C1

2.15e-0326782EFO_0021529
Diseasehearing impairment

EYA4 COL11A2 MYO15A

2.26e-0398783C1384666
Diseaseneurotic disorder

ARPP21 MYO1H PCLO

2.46e-03101783EFO_0004257
DiseaseColorectal Carcinoma

EYA4 SACS PSMA2 SLC22A15 LRP1 SPAG17 RHEB

2.57e-03702787C0009402
Diseasesodium measurement

ARPP21 HDAC8 DNAJC1

2.60e-03103783EFO_0009282

Protein segments in the cluster

PeptideGeneStartEntry
PTQILYTTYYESISN

CERS4

281

Q9HA82
RYQLGTSPYVYQLTT

CNTNAP1

1121

P78357
PEVSQYIYQVYDSIL

AP2B1

921

P63010
VNSPSYLNSGPLVYY

CSRNP2

406

Q9H175
IERYPDLPYVYVNSS

HTR3B

126

O95264
AYLQYRQPVVIYSSP

CRAT

106

P43155
VIPQAPQYYDEYVTF

ANKRD12

1856

Q6UB98
PVYTPLETTYIQSYD

DNAJC1

286

Q96KC8
YPSGQYPTSTTQQYR

ARPP21

641

Q9UBL0
QTQPYAVYPQATQTY

EYA3

101

Q99504
QPTLYQIPSLYCSYE

P4HA3

311

Q7Z4N8
TVTRYLPKYPYESAQ

DEPDC5

871

O75140
TSENQLVYYPSITYA

LDLRAD3

161

Q86YD5
AYYTQPVYAAQPHVI

FAM168A

151

Q92567
DIVDYNYPATLTPSY

NRAP

451

Q86VF7
IYTYIGSILVSVNPY

MYO15A

1251

Q9UKN7
YPIVEALYQTTYPEY

GPR155

151

Q7Z3F1
IPYELYTPATYQLTE

JMJD7

206

P0C870
LADQLPLQTYTAVYY

SLC66A1

91

Q6ZP29
PYYNYIISFTVPDID

LRP1

1601

Q07954
IYDVYRYLPPATQVV

EIF4A3

201

P38919
SQLVPPTSPYTQYQY

PCLO

3876

Q9Y6V0
LYTYTLPQSYHTPIK

OR2T6

256

Q8NHC8
QLSPLPHLYSVSYYQ

FRYL

1256

O94915
YVITSPPRYGQIEYV

FREM1

1431

Q5H8C1
QEPQSQPTESLYYDY

COL11A2

261

P13942
VTETLYSPVYSYQPR

KCNU1

1081

A8MYU2
YSPVYSYQPRTNSLS

KCNU1

1086

A8MYU2
VPNVDYYPDRTYIFT

RASGEF1B

51

Q0VAM2
LVYPPYVYQTQSSAF

HIPK3

6

Q9H422
YTQYRTQDYPSVPTL

ITGB4

296

P16144
PLYTYLTLLPATYNS

GPR3

276

P46089
NTRIEPYYSIYNSSP

GPR75

476

O95800
PVQYYFTLAQQPTAV

NFYC

141

Q13952
IYIIPPAYSSVVTYV

FANCB

226

Q8NB91
PQTYSIDINGYILVY

RHEB

71

Q15382
PYTITNVFYEQYLTI

NPC1L1

1121

Q9UHC9
EALNIYQFTPPHYYT

PDP2

371

Q9P2J9
SQPSSQYRIKEYPLY

FRMD4A

826

Q9P2Q2
YSQTGQPYSLPTYDL

EYA4

181

O95677
DPKYAYIQVTYVTPF

DOCK10

1941

Q96BY6
QYLQIYAVTPIPDYV

DOCK3

1416

Q8IZD9
PNTTYRNLLYIYPQS

DOCK7

556

Q96N67
QTTTYLPENFTYSPY

B4GALT6

91

Q9UBX8
SLDYSYSPVQLPSYA

COLCA2

46

A8K830
TTYCPAQYTIYEPVI

LYST

1746

Q99698
PYYYLDPVLIENSIS

ALOX12B

686

O75342
YGYNLSVVNAPTPYI

SLC2A9

71

Q9NRM0
YPVSTYNLFYPSNAI

KRTAP15-1

21

Q3LI76
YYIQLESGQVPVYAV

AHCTF1

256

Q8WYP5
ITQYVQAYPTYPNSP

DAZL

161

Q92904
TLTVQPAYQPEYLYT

FRY

1721

Q5TBA9
GQSLVPVYIYSPEYV

HDAC8

11

Q9BY41
LYPVTSRPYYVDLNQ

DMBT1

2266

Q9UGM3
NIVYIYTSELYPTVI

SLC22A15

416

Q8IZD6
SYQPTYTYAIIVQEV

SACS

4196

Q9NZJ4
YVFRNESIVPYSPYE

CNTN3

761

Q9P232
TPSAQYSQAYYPTAV

HSF5

296

Q4G112
IPGLNLSQQEYYPYV

ATP6V1C1

356

P21283
TYYDPNTQQEVYVPQ

RBM6

806

P78332
YTPTIPDAVTGYYLN

TAF10

126

Q12962
YSSYPIKLFYTSNIP

SEC61A2

276

Q9H9S3
ISAQPPVSTEYTYYQ

SECISBP2L

96

Q93073
NPYYPATNFSTVYLE

PLA2R1

1436

Q13018
NIPTQISGSNYYLYP

SPAG17

1026

Q6Q759
VYYPIIFSQYDPKVT

CHSY3

741

Q70JA7
NFYTLSIDYPRVNYP

RNASE13

31

Q5GAN3
YNTYPIKLFYTSNIP

SEC61A1

276

P61619
VRVYSPYQDYYEVVP

PLEKHB1

166

Q9UF11
IYPSSYRVDSSNYNP

PLCH2

681

O75038
APYRILYQTPDSLVY

TBC1D9

61

Q6ZT07
NVQYPYQLYIAPSTS

ZBTB44

371

Q8NCP5
DVIFLQEVIPPYYSY

TDP2

146

O95551
QYYLVYQEPIPTAQL

PSMA2

96

P25787
TSPTPTYLVYYAEVN

ROS1

1481

P08922
PLQQTNVYTTTYYPS

SEMA5B

1116

Q9P283
NVYTTTYYPSPLNKH

SEMA5B

1121

Q9P283
IYQSAINPPHYELIY

TMEM209

496

Q96SK2
YFEQYSRSYEQVPPQ

TJP1

1191

Q07157
HIYPIVQYDVYSQEP

TRAPPC10

771

P48553
YPQAVYFPIRTLYLT

TRRAP

3261

Q9Y4A5
PYSVATLVQYLPFYA

TAS2R4

241

Q9NYW5
YDKTVYQSIQPIYPA

ZNF606

266

Q8WXB4
YVKIYITVRNPQYNP

TSHR

601

P16473
IYTYIGPVLVSVNPY

MYO1C

76

O00159
IYTYIGTLLVSVNPY

MYO1H

41

Q8N1T3
IYTYVANILIAVNPY

MYO6

86

Q9UM54