Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF711 ZNF355P ZNF430 ZNF93 ZNF384 ZNF182 ZSCAN12 ZNF585A KLF10 ZNF732 ZNF41 GLI1 GLI2 GLI3 ZNF189 ZNF66 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF81 ZNF860 ZNF524 HSF2 ZNF107 ZNF98 PRDM16 ZNF416 ZNF714 UTY ZFX ZFY ZNF639 ZNF239 ZNF585B	4.07e-21	1244	87	36	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF711 ZNF355P ZNF430 ZNF93 ZNF384 ZNF182 ZSCAN12 ZNF585A KLF10 ZNF732 ZNF41 GLI1 GLI2 GLI3 ZNF189 ZNF66 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF81 ZNF860 ZNF524 HSF2 ZNF107 ZNF98 PRDM16 ZNF416 ZNF714 UTY ZFX ZFY ZNF639 ZNF239 ZNF585B	8.30e-21	1271	87	36	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF711 ZNF355P ZNF430 ZNF93 ZNF384 ZNF182 ZSCAN12 ZNF585A KLF10 ZNF732 TSHZ2 ZNF41 GLI1 GLI2 GLI3 ZNF189 ZNF66 ZBTB40 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF81 ZNF860 HSF2 ZNF107 ZNF98 PRDM16 MYRF ZNF416 ZNF714 ZFX ZFY ZNF639 ZNF239 ZNF585B	2.70e-20	1412	87	37	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF711 ZNF355P ZNF430 ZNF93 ZNF384 ZNF182 ZSCAN12 ZNF585A KLF10 ZNF732 ZNF41 GLI1 GLI2 GLI3 ZNF189 ZNF66 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF81 ZNF860 ZNF524 HSF2 ZNF107 ZNF98 PRDM16 ZNF416 ZNF714 UTY ZFX ZFY ZNF639 ZNF239 ZNF585B	7.71e-19	1459	87	36	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF384 ZNF585A KLF10 GLI1 GLI2 MECOM HSF2 ZNF107 PRDM16 ZFX ZFY ZNF639 ZNF585B	8.86e-07	560	87	13	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF384 ZNF585A KLF10 GLI1 GLI2 MECOM HSF2 ZNF107 PRDM16 ZFX ZFY ZNF639 ZNF585B	9.98e-07	566	87	13	GO:0001216
GeneOntologyMolecularFunction	chromatin DNA binding	H2AC1 GLI2 UTY JMJD1C ZFX ZFY	9.03e-05	167	87	6	GO:0031490
GeneOntologyMolecularFunction	chromatin insulator sequence binding	ZFX ZFY	3.89e-04	7	87	2	GO:0043035
GeneOntologyMolecularFunction	histone H3K9 monomethyltransferase activity	MECOM PRDM16	5.17e-04	8	87	2	GO:0140948
GeneOntologyMolecularFunction	histone H3K9me2 methyltransferase activity	MECOM PRDM16	8.26e-04	10	87	2	GO:0140947
GeneOntologyMolecularFunction	dioxygenase activity	TET2 PHYHD1 UTY JMJD1C	8.89e-04	98	87	4	GO:0051213
GeneOntologyMolecularFunction	JUN kinase kinase kinase activity	MAP3K20 MAP3K21	1.20e-03	12	87	2	GO:0004706
GeneOntologyMolecularFunction	histone H3K9 methyltransferase activity	MECOM PRDM16	1.42e-03	13	87	2	GO:0046974
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	TET2 PHYHD1 UTY	2.87e-03	65	87	3	GO:0016706
GeneOntologyMolecularFunction	chromatin binding	BPHL H2AC1 GLI1 GLI2 GLI3 UTY JMJD1C ZFX ZFY	4.85e-03	739	87	9	GO:0003682
GeneOntologyBiologicalProcess	protein-DNA complex organization	TET2 BDP1 ZNF93 EPC2 UBN1 MYO1C CENPC BAZ2B H2AC1 MECOM METTL4 PRDM16 UTY JMJD1C SPTY2D1 ZFY	5.14e-06	999	89	16	GO:0071824
GeneOntologyBiologicalProcess	chromatin remodeling	TET2 ZNF93 UBN1 MYO1C BAZ2B H2AC1 MECOM METTL4 PRDM16 UTY JMJD1C SPTY2D1 ZFY	1.70e-05	741	89	13	GO:0006338
GeneOntologyBiologicalProcess	notochord regression	GLI1 GLI2	1.84e-05	2	89	2	GO:0060032
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	ZNF711 TET2 ZNF384 ZNF585A KLF10 MYO1C GLI1 GLI2 GLI3 MECOM HSF2 ZNF107 PRDM16 PHIP ZFX ZFY ZNF639 ZNF585B	2.27e-05	1390	89	18	GO:0045944
GeneOntologyBiologicalProcess	chromatin organization	TET2 ZNF93 EPC2 UBN1 MYO1C BAZ2B H2AC1 MECOM METTL4 PRDM16 UTY JMJD1C SPTY2D1 ZFY	2.83e-05	896	89	14	GO:0006325
GeneOntologyBiologicalProcess	smoothened signaling pathway involved in ventral spinal cord interneuron specification	GLI2 GLI3	5.51e-05	3	89	2	GO:0021775
GeneOntologyBiologicalProcess	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	GLI2 GLI3	5.51e-05	3	89	2	GO:0021776
GeneOntologyBiologicalProcess	smoothened signaling pathway involved in ventral spinal cord patterning	GLI2 GLI3	5.51e-05	3	89	2	GO:0021910
GeneOntologyBiologicalProcess	negative regulation of gene expression, epigenetic	ZNF93 H2AC1 METTL4 UTY SPTY2D1 ZFY	2.49e-04	203	89	6	GO:0045814
GeneOntologyBiologicalProcess	ventral midline development	GLI1 GLI2	2.73e-04	6	89	2	GO:0007418
GeneOntologyCellularComponent	GLI-SUFU complex	GLI1 GLI2 GLI3	2.97e-07	4	89	3	GO:1990788
Domain	zf-C2H2	ZNF711 ZNF430 ZNF93 ZNF384 ZNF182 ZNF585A KLF10 ZNF732 TSHZ2 ZNF41 GLI1 GLI2 ZNF189 ZBTB40 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF81 ZNF860 ZNF524 ZNF107 ZNF98 PRDM16 ZNF416 ZNF282 ZNF714 ZNF702P ZFX ZFY ZNF639 ZNF239 ZNF585B	2.72e-26	693	87	34	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF711 ZNF430 ZNF93 ZNF384 ZNF182 ZNF585A KLF10 ZNF732 TSHZ2 ZNF41 GLI1 GLI2 GLI3 ZNF189 ZBTB40 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF81 ZNF860 ZNF524 ZNF107 ZNF98 PRDM16 ZNF416 ZNF282 ZNF714 ZNF702P ZFX ZFY ZNF639 ZNF239 ZNF585B	6.59e-26	775	87	35	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF711 ZNF430 ZNF93 ZNF384 ZNF182 ZNF585A KLF10 ZNF732 TSHZ2 ZNF41 GLI1 GLI2 GLI3 ZNF189 ZBTB40 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF81 ZNF860 ZNF524 ZNF107 ZNF98 PRDM16 ZNF416 ZNF282 ZNF714 ZNF702P ZFX ZFY ZNF639 ZNF239 ZNF585B	7.19e-26	777	87	35	PS00028
Domain	Znf_C2H2	ZNF711 ZNF430 ZNF93 ZNF384 ZNF182 ZNF585A KLF10 ZNF732 TSHZ2 ZNF41 GLI1 GLI2 GLI3 ZNF189 ZBTB40 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF81 ZNF860 ZNF524 ZNF107 ZNF98 PRDM16 ZNF416 ZNF282 ZNF714 ZNF702P ZFX ZFY ZNF639 ZNF239 ZNF585B	2.36e-25	805	87	35	IPR007087
Domain	-	ZNF711 ZNF430 ZNF93 ZNF384 ZNF182 ZNF585A KLF10 ZNF732 ZNF41 GLI1 GLI2 GLI3 ZNF189 ZBTB40 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF81 ZNF860 ZNF524 ZNF107 ZNF98 PRDM16 ZNF416 ZNF282 ZNF714 ZFX ZFY ZNF639 ZNF239 ZNF585B	2.44e-25	679	87	33	3.30.160.60
Domain	ZnF_C2H2	ZNF711 ZNF430 ZNF93 ZNF384 ZNF182 ZNF585A KLF10 ZNF732 TSHZ2 ZNF41 GLI1 GLI2 GLI3 ZNF189 ZBTB40 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF81 ZNF860 ZNF524 ZNF107 ZNF98 PRDM16 ZNF416 ZNF282 ZNF714 ZNF702P ZFX ZFY ZNF639 ZNF239 ZNF585B	2.67e-25	808	87	35	SM00355
Domain	Znf_C2H2/integrase_DNA-bd	ZNF711 ZNF430 ZNF93 ZNF384 ZNF182 ZNF585A KLF10 ZNF732 ZNF41 GLI1 GLI2 GLI3 ZNF189 ZBTB40 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF81 ZNF860 ZNF524 ZNF107 ZNF98 PRDM16 ZNF416 ZNF282 ZNF714 ZFX ZFY ZNF639 ZNF239 ZNF585B	4.88e-25	694	87	33	IPR013087
Domain	Znf_C2H2-like	ZNF711 ZNF430 ZNF93 ZNF384 ZNF182 ZNF585A KLF10 ZNF732 TSHZ2 ZNF41 GLI1 GLI2 GLI3 ZNF189 ZBTB40 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF81 ZNF860 ZNF524 ZNF107 ZNF98 PRDM16 ZNF416 ZNF282 ZNF714 ZFX ZFY ZNF639 ZNF239 ZNF585B	2.51e-24	796	87	34	IPR015880
Domain	KRAB	ZNF430 ZNF93 ZNF182 ZNF585A ZNF732 ZNF41 ZNF189 ZNF506 ZNF737 ZNF766 ZNF81 ZNF860 ZNF98 ZNF738 ZNF416 ZNF282 ZNF714 ZNF585B	4.61e-14	358	87	18	PS50805
Domain	zf-C2H2_6	ZNF93 ZNF384 ZNF182 ZNF732 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF860 ZNF524 ZNF107 ZNF98 PRDM16 ZNF416 ZNF282 ZNF714	7.61e-14	314	87	17	PF13912
Domain	KRAB	ZNF430 ZNF93 ZNF182 ZNF585A ZNF732 ZNF41 ZNF189 ZNF506 ZNF737 ZNF766 ZNF81 ZNF860 ZNF98 ZNF738 ZNF416 ZNF282 ZNF714 ZNF585B	7.74e-14	369	87	18	SM00349
Domain	KRAB	ZNF430 ZNF93 ZNF182 ZNF585A ZNF732 ZNF41 ZNF189 ZNF506 ZNF737 ZNF766 ZNF81 ZNF860 ZNF98 ZNF738 ZNF416 ZNF282 ZNF714 ZNF585B	8.11e-14	370	87	18	IPR001909
Domain	KRAB	ZNF430 ZNF93 ZNF182 ZNF585A ZNF732 ZNF41 ZNF189 ZNF506 ZNF737 ZNF766 ZNF81 ZNF860 ZNF98 ZNF738 ZNF416 ZNF282 ZNF585B	6.38e-13	358	87	17	PF01352
Domain	Zfx_Zfy_act	ZNF711 ZFX ZFY	9.76e-08	3	87	3	PF04704
Domain	Transcrp_activ_Zfx/Zfy-dom	ZNF711 ZFX ZFY	9.76e-08	3	87	3	IPR006794
Domain	Evi1/Prdm16	MECOM PRDM16	2.14e-05	2	87	2	IPR030413
Domain	JmjC	UTY JMJD1C	5.54e-03	24	87	2	PF02373
Domain	Bromodomain_CS	BAZ2B PHIP	6.48e-03	26	87	2	IPR018359
Domain	AT_hook	BOD1L1 ZNF524	6.98e-03	27	87	2	SM00384
Domain	AT_hook_DNA-bd_motif	BOD1L1 ZNF524	6.98e-03	27	87	2	IPR017956
Domain	JMJC	UTY JMJD1C	9.72e-03	32	87	2	PS51184
Domain	JmjC_dom	UTY JMJD1C	9.72e-03	32	87	2	IPR003347
Domain	JmjC	UTY JMJD1C	1.03e-02	33	87	2	SM00558
Pathway	REACTOME_GLI_PROTEINS_BIND_PROMOTERS_OF_HH_RESPONSIVE_GENES_TO_PROMOTE_TRANSCRIPTION	GLI1 GLI2 GLI3	2.94e-06	7	63	3	M27501
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF711 ZNF430 ELOA ZNF585A ZNF732 ZNF41 GLI2 GLI3 ZNF189 ZNF506 ZNF737 ICE1 ZNF860 ZNF738 ZNF416 ZNF282 ZNF714 ZNF585B	2.32e-05	1387	63	18	M734
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY	GLI1 GLI2 GLI3	2.99e-05	14	63	3	M47414
Pathway	BIOCARTA_SHH_PATHWAY	GLI1 GLI2 GLI3	3.73e-05	15	63	3	MM1498
Pathway	WP_HEDGEHOG_SIGNALING_WP47	GLI1 GLI2 GLI3	4.57e-05	16	63	3	M39675
Pathway	BIOCARTA_SHH_PATHWAY	GLI1 GLI2 GLI3	4.57e-05	16	63	3	M11792
Pathway	WP_HEDGEHOG_SIGNALING_PATHWAY	GLI1 GLI2 GLI3	1.23e-04	22	63	3	MM15924
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF711 ZNF355P BDP1 ZNF93 ELOA ZNF585A MYO1C ZNF189 BOD1L1 ICE1 ZNF107 ZNF416 ZNF282 ZNF585B	1.32e-04	1022	63	14	MM15436
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY	GLI1 GLI2 GLI3	2.86e-04	29	63	3	M47372
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY	GLI1 GLI2 GLI3	2.86e-04	29	63	3	M47377
Pathway	WP_TUMOR_SUPPRESSOR_ACTIVITY_OF_SMARCB1	GLI1 GLI2 GLI3	3.50e-04	31	63	3	M39522
Pathway	WP_HEDGEHOG_SIGNALING_WP4249	GLI1 GLI2 GLI3	9.24e-04	43	63	3	M39706
Pathway	KEGG_MEDICUS_REFERENCE_MLK_JNK_SIGNALING_PATHWAY	MAP3K20 MAP3K21	1.26e-03	12	63	2	M47929
Pathway	PID_HEDGEHOG_GLI_PATHWAY	GLI1 GLI2 GLI3	1.27e-03	48	63	3	M219
Pathway	KEGG_BASAL_CELL_CARCINOMA	GLI1 GLI2 GLI3	1.89e-03	55	63	3	M17807
Pathway	KEGG_HEDGEHOG_SIGNALING_PATHWAY	GLI1 GLI2 GLI3	1.99e-03	56	63	3	M1053
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF711 ZNF355P ZNF93 ELOA ZNF585A ZNF189 ZNF107 ZNF416 ZNF282 ZNF585B	2.01e-03	768	63	10	MM14851
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF430 ZNF93 ZNF182 ZNF41 ZNF737 ZNF766 ZNF107 ZNF98 ZNF738	1.37e-09	181	92	9	37372979
Pubmed	Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.	GLI1 GLI2 GLI3	1.79e-08	3	92	3	26010061
Pubmed	A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.	GLI1 GLI2 GLI3	1.79e-08	3	92	3	8387379
Pubmed	Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1.	ZNF182 ZNF41 ZNF81	1.79e-08	3	92	3	8088786
Pubmed	Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.	GLI1 GLI2 GLI3	1.79e-08	3	92	3	16571352
Pubmed	Different expression patterns of Gli1-3 in mouse embryonic maxillofacial development.	GLI1 GLI2 GLI3	1.79e-08	3	92	3	22178118
Pubmed	Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.	ZNF711 ZFX ZFY	1.79e-08	3	92	3	32406922
Pubmed	Gli family members are differentially expressed during the mitotic phase of spermatogenesis.	GLI1 GLI2 GLI3	1.79e-08	3	92	3	9178901
Pubmed	Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.	GLI1 GLI2 GLI3	1.79e-08	3	92	3	8378770
Pubmed	Zinc finger protein genes in the mouse genome.	GLI1 MECOM ZFX ZFY	2.23e-08	12	92	4	1797234
Pubmed	Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans.	MYO6 GLI1 GLI2 GLI3	3.22e-08	13	92	4	18632939
Pubmed	Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region.	GLI1 GLI2 GLI3	7.15e-08	4	92	3	9027508
Pubmed	Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina.	GLI1 GLI2 GLI3	7.15e-08	4	92	3	22281533
Pubmed	Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.	GLI1 GLI2 GLI3	7.15e-08	4	92	3	9006072
Pubmed	Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.	GLI1 GLI2 GLI3	7.15e-08	4	92	3	27793025
Pubmed	Expression profile of Gli family members and Shh in normal and mutant mouse limb development.	GLI1 GLI2 GLI3	7.15e-08	4	92	3	9438426
Pubmed	Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development.	GLI1 GLI2 GLI3	7.15e-08	4	92	3	8150204
Pubmed	Anorectal malformations caused by defects in sonic hedgehog signaling.	GLI1 GLI2 GLI3	7.15e-08	4	92	3	11485934
Pubmed	Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1.	GLI1 GLI2 GLI3	7.15e-08	4	92	3	10531011
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF93 ZNF737 ZNF107 ZNF98	8.14e-08	16	92	4	8467795
Pubmed	A census of human transcription factors: function, expression and evolution.	ZNF711 ZNF384 ZNF182 KLF10 TSHZ2 GLI1 GLI2 GLI3 ZNF524 HSF2 MYRF ZNF282 ZFX ZFY	1.18e-07	908	92	14	19274049
Pubmed	Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development.	GLI1 GLI2 GLI3 PRDM16	1.72e-07	19	92	4	25848030
Pubmed	SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	20711444
Pubmed	Functional compensation in Hedgehog signaling during mouse prostate development.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	16707121
Pubmed	A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	9118802
Pubmed	Evidence for the involvement of the Gli gene family in embryonic mouse lung development.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	9268579
Pubmed	Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	24218555
Pubmed	Gli regulation by the opposing activities of fused and suppressor of fused.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	10806483
Pubmed	p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	26282181
Pubmed	Gli1 is a target of Sonic hedgehog that induces ventral neural tube development.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	9216996
Pubmed	Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	15614767
Pubmed	Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	19996099
Pubmed	Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	16611981
Pubmed	Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	15315762
Pubmed	Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	10564661
Pubmed	Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	19593328
Pubmed	Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	26120032
Pubmed	Expression pattern of Irx1 and Irx2 during mouse digit development.	GLI1 GLI2 GLI3	1.78e-07	5	92	3	11472848
Pubmed	Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells.	GLI1 GLI2 GLI3	3.56e-07	6	92	3	21549329
Pubmed	RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6.	GLI1 GLI2 GLI3	3.56e-07	6	92	3	33895473
Pubmed	Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.	GLI1 GLI2 GLI3	3.56e-07	6	92	3	14681189
Pubmed	Targeted disruption of Sonic Hedgehog in the mouse adrenal leads to adrenocortical hypoplasia.	GLI1 GLI2 GLI3	3.56e-07	6	92	3	19536807
Pubmed	A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.	GLI1 GLI2 GLI3	3.56e-07	6	92	3	12385751
Pubmed	Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.	GLI1 GLI2 GLI3	3.56e-07	6	92	3	31279575
Pubmed	Physical and functional interactions between Zic and Gli proteins.	GLI1 GLI2 GLI3	3.56e-07	6	92	3	11238441
Pubmed	Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium.	GLI1 GLI2 GLI3	3.56e-07	6	92	3	19432668
Pubmed	Titration of GLI3 repressor activity by sonic hedgehog signaling is critical for maintaining multiple adult neural stem cell and astrocyte functions.	GLI1 GLI2 GLI3	3.56e-07	6	92	3	24174682
Pubmed	Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling.	GLI1 GLI2 GLI3	3.56e-07	6	92	3	17202190
Pubmed	Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.	GLI1 GLI2 GLI3	3.56e-07	6	92	3	16254602
Pubmed	Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium.	GLI1 GLI2 GLI3	3.56e-07	6	92	3	21209912
Pubmed	Irx1 and Irx2 expression in early lung development.	GLI1 GLI2 GLI3	3.56e-07	6	92	3	11472847
Pubmed	Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice.	GLI1 GLI2 GLI3	6.22e-07	7	92	3	9152005
Pubmed	A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.	GLI1 GLI2 GLI3	6.22e-07	7	92	3	21653639
Pubmed	Analysis of the Sonic Hedgehog signaling pathway in normal and abnormal bladder development.	GLI1 GLI2 GLI3	6.22e-07	7	92	3	23308271
Pubmed	Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain.	GLI1 GLI2 GLI3	6.22e-07	7	92	3	20943901
Pubmed	Hedgehog regulates Norrie disease protein to drive neural progenitor self-renewal.	GLI1 GLI2 GLI3	6.22e-07	7	92	3	23201751
Pubmed	FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine.	GLI1 GLI2 GLI3	6.22e-07	7	92	3	19049965
Pubmed	Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus.	GLI1 GLI2 GLI3	6.22e-07	7	92	3	14568100
Pubmed	Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line.	GLI1 GLI2 GLI3	6.22e-07	7	92	3	28799057
Pubmed	The GLI-Kruppel family of human genes.	GLI1 GLI2 GLI3	6.22e-07	7	92	3	2850480
Pubmed	Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus.	GLI1 GLI2 GLI3	6.22e-07	7	92	3	9731531
Pubmed	Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3.	GLI1 GLI2 GLI3	6.22e-07	7	92	3	12435627
Pubmed	Gli3-mediated repression of Hedgehog targets is required for normal mammary development.	GLI1 GLI2 GLI3	6.22e-07	7	92	3	16914490
Pubmed	Morphogenesis.	GLI1 GLI2 GLI3	9.94e-07	8	92	3	9988217
Pubmed	Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1.	GLI1 GLI2 GLI3	9.94e-07	8	92	3	10529434
Pubmed	Gli1 is not required for Pdgfralpha expression during mouse embryonic development.	GLI1 GLI2 GLI3	9.94e-07	8	92	3	15811134
Pubmed	GLI transcriptional repression is inert prior to Hedgehog pathway activation.	GLI1 GLI2 GLI3	9.94e-07	8	92	3	35145123
Pubmed	Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity.	GLI1 GLI2 GLI3	9.94e-07	8	92	3	10631181
Pubmed	Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube.	GLI1 GLI2 GLI3	9.94e-07	8	92	3	22265416
Pubmed	Expression of hedgehog signalling components in adult mouse testis.	GLI1 GLI2 GLI3	9.94e-07	8	92	3	16958114
Pubmed	The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh.	GLI1 GLI2 GLI3	9.94e-07	8	92	3	28533268
Pubmed	Spatiotemporal expression of sonic hedgehog signalling molecules in the embryonic mesencephalic dopaminergic neurons.	GLI1 GLI2 GLI3	9.94e-07	8	92	3	34767969
Pubmed	Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation.	GLI1 GLI2 GLI3	9.94e-07	8	92	3	12221011
Pubmed	Unique functions of Sonic hedgehog signaling during external genitalia development.	GLI1 GLI2 GLI3	9.94e-07	8	92	3	11684660
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF355P ZNF93 ZNF506 ZNF107	1.04e-06	29	92	4	14563677
Pubmed	Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	38848388
Pubmed	Sonic Hedgehog mediator Gli2 regulates bladder mesenchymal patterning.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	18710724
Pubmed	Gli3 null mice display glandular overgrowth of the developing stomach.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	16247775
Pubmed	New Insights into Development of Female Reproductive Tract-Hedgehog-Signal Response in Wolffian Tissues Directly Contributes to Uterus Development.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	33530552
Pubmed	Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	27802276
Pubmed	Identification of GLI Mutations in Patients With Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	26261006
Pubmed	Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	23249739
Pubmed	Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett's metaplasia.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	25083987
Pubmed	Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	17395647
Pubmed	Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	15315763
Pubmed	Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	10725236
Pubmed	The loss of Hh responsiveness by a non-ciliary Gli2 variant.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	25834022
Pubmed	Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	29311969
Pubmed	The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis.	GLI1 GLI2 GLI3	1.49e-06	9	92	3	11748155
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF93 ZSCAN12 KLF10 GLI3 EIF2B2 ZNF506 ZBTB41 PRDM16 ZNF282 UTY ZNF639 ZNF239	1.51e-06	808	92	12	20412781
Pubmed	The Shh signalling pathway in early tooth development.	GLI1 GLI2 GLI3	2.12e-06	10	92	3	10512189
Pubmed	The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling.	GLI1 GLI2 GLI3	2.12e-06	10	92	3	19549984
Pubmed	Increasing Sufu gene dosage reveals its unorthodox role in promoting polydactyly and medulloblastoma tumorigenesis.	GLI1 GLI2 GLI3	2.12e-06	10	92	3	38358805
Pubmed	CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.	GLI1 GLI2 GLI3	2.12e-06	10	92	3	18298960
Pubmed	Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction.	GLI1 GLI2 GLI3	2.12e-06	10	92	3	14602680
Pubmed	Patched1 patterns Fibroblast growth factor 10 and Forkhead box F1 expression during pulmonary branch formation.	GLI1 GLI2 GLI3	2.12e-06	10	92	3	28939119
Pubmed	Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.	GLI1 GLI2 GLI3	2.12e-06	10	92	3	16284117
Pubmed	Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.	GLI1 GLI2 GLI3	2.12e-06	10	92	3	12812795
Pubmed	Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development.	GLI1 GLI2 GLI3	2.12e-06	10	92	3	15496441
Pubmed	Fusion of lung lobes and vessels in mouse embryos heterozygous for the forkhead box f1 targeted allele.	GLI1 GLI2 GLI3	2.12e-06	10	92	3	11943666
Cytoband	19p12	ZNF430 ZNF93 ZNF66 ZNF737 ZNF98 ZNF738 ZNF714	6.71e-10	90	92	7	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF430 ZNF93 ZNF66 ZNF737 ZNF98 ZNF738 ZNF714	5.71e-09	122	92	7	chr19p12
Cytoband	2q24.2	BAZ2B MAP3K20	8.94e-04	22	92	2	2q24.2
Cytoband	Xp11.23	ZNF182 ZNF41 ZNF81	9.43e-04	95	92	3	Xp11.23
Cytoband	20q13.2	GCNT7 TSHZ2	1.35e-03	27	92	2	20q13.2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF711 ZNF430 ZNF93 ZNF384 ZNF182 ZSCAN12 ZNF585A KLF10 ZNF732 TSHZ2 ZNF41 GLI1 GLI2 GLI3 ZNF189 ZBTB40 ZNF506 ZNF737 MECOM ZNF766 ZBTB41 ZNF81 ZNF860 ZNF524 ZNF107 ZNF98 PRDM16 ZNF416 ZNF282 ZNF714 ZFX ZFY ZNF639 ZNF239 ZNF585B	8.99e-33	718	63	35	28
GeneFamily	X-linked mental retardation\|Angiotensin receptors	ZNF711 ZNF41 ZNF81	8.34e-04	53	63	3	103
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	MECOM PRDM16	1.57e-03	17	63	2	1197
GeneFamily	WD repeat domain containing\|DDB1 and CUL4 associated factors	DCAF10 PHIP	1.76e-03	18	63	2	498
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K20 MAP3K21	3.14e-03	24	63	2	654
GeneFamily	PHD finger proteins\|Lysine demethylases	UTY JMJD1C	3.14e-03	24	63	2	485
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	MECOM PRDM16	6.24e-03	34	63	2	487
Coexpression	YAGI_AML_WITH_T_9_11_TRANSLOCATION	ABAT MYO6 HSF2 JMJD1C PHIP ZFX	6.97e-06	131	92	6	M16922
CoexpressionAtlas	facebase_RNAseq_e10.5_MaxArch_2500_K3	ZNF711 TET2 ZNF93 EPC2 ZNF182 ZSCAN12 ZNF585A SNCAIP CENPC ZNF41 GLI2 GLI3 DOCK7 ZNF506 BOD1L1 HSF2 PRDM16	1.50e-05	1252	89	17	facebase_RNAseq_e10.5_MaxArch_2500_K3
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 BDP1 CENPC BOD1L1 ZCCHC2 BIRC6 JMJD1C PHIP	8.96e-09	200	92	8	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-Bergmann_glial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNCAIP PTPRZ1 GLI1 GLI2 GLI3 PHYHD1	2.23e-06	183	92	6	99bb4ceb92f6467f2359a42ab2cff6df18825a30
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8\|TCGA-Bladder / Sample_Type by Project: Shred V9	ZNF66 ZNF737 ZNF107 ZNF738 ZNF714	1.50e-05	150	92	5	1aa9320d97ff10994ea024751790524fe133aba9
ToppCell	10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-HSC/MPP\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	DYTN MECOM PHYHD1 LRRC70 PRDM16	1.81e-05	156	92	5	bb2876bdf2375866d7509eba3c48322326349fa8
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TET2 CENPC FCGR3B BOD1L1 METTL4	2.82e-05	171	92	5	2b7c5a557c4bc5c573211c4d618bdd6766a24916
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TET2 CENPC FCGR3B BOD1L1 METTL4	2.82e-05	171	92	5	dcb15bc54aeea06ef8f07f1134f3ff1e21ac0e4f
ToppCell	ASK452-Immune-B_cell\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	ABAT ZSCAN12 ARRDC1-AS1 DOCK7 ZNF506	3.06e-05	174	92	5	69723f5666abc3af5f0431901a60246c9915ef81
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK7 MECOM MAP3K21 ZNF98 PRDM16	3.60e-05	180	92	5	788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4\|TCGA-Thryoid / Sample_Type by Project: Shred V9	ZNF430 UBN1 ZNF714 CEP170B ZNF702P	3.99e-05	184	92	5	d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK7 MECOM MAP3K21 ZNF98 PRDM16	4.42e-05	188	92	5	4154f4787483c7e076e87a187733a9f666742c3d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK7 MECOM MAP3K21 ZNF98 PRDM16	4.54e-05	189	92	5	8ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK7 MECOM MAP3K21 ZNF98 PRDM16	4.54e-05	189	92	5	90aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK7 MECOM MAP3K21 ZNF98 PRDM16	4.65e-05	190	92	5	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PTPRZ1 GLI2 GLI3 PHYHD1 PRDM16	5.01e-05	193	92	5	b03d908d4b8940927f72c76a1b0f237d13f39056
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PTPRZ1 GLI2 GLI3 PHYHD1 PRDM16	5.01e-05	193	92	5	40edc07b6e7f19f6ee885fa5af0b63ef1b0f2468
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM FHIT MAP3K21 PRDM16 HYDIN	5.14e-05	194	92	5	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	Non-neuronal-Dividing-Radial_Glia-vRG-20\|World / Primary Cells by Cluster	MYO6 PTPRZ1 GLI3 PRDM16 PHIP	5.66e-05	198	92	5	bce0bc1e3f2257e0f42a1fa6e5b57cf71e4514ba
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 KLF10 FCGR3B BAZ2B JMJD1C	5.66e-05	198	92	5	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	BAZ2B MECOM FHIT BIRC6 UTY	5.79e-05	199	92	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Control-Control-Myeloid-Neutrophil\|Control / Disease, condition lineage and cell class	UBN1 FCGR3B BAZ2B BOD1L1 JMJD1C	5.93e-05	200	92	5	95c41f147a1594d49e73cb56d86d301c3115ce20
Drug	Clorgyline	BDP1 CENPC MYO6 BAZ2B BOD1L1 PHIP ZFY	4.69e-06	168	90	7	ctd:D003010
Drug	vinylene	ZNF93 KLF10 GLI1 ZNF81 ZNF107 ZNF98 ZFX ZFY	5.81e-06	245	90	8	CID000006326
Drug	36355A	ABAT AFF2 MITD1	1.28e-05	12	90	3	CID000013729
Disease	primary bacterial infectious disease (implicated_via_orthology)	GLI1 GLI2 GLI3	1.65e-06	9	81	3	DOID:0050338 (implicated_via_orthology)
Disease	omega-6:omega-3 polyunsaturated fatty acid ratio	MAP4K5 DOCK7 MYRF JMJD1C	1.10e-05	50	81	4	EFO_0010732
Disease	polyunsaturated fatty acids to monounsaturated fatty acids ratio	MAP4K5 DOCK7 MYRF JMJD1C	1.19e-05	51	81	4	EFO_0022302
Disease	cholesteryl esters to total lipids in very large VLDL percentage	MAP4K5 DOCK7 MYRF JMJD1C	1.39e-05	53	81	4	EFO_0022258
Disease	cholesterol to total lipids in very large VLDL percentage	MAP4K5 DOCK7 MYRF JMJD1C	1.50e-05	54	81	4	EFO_0022244
Disease	free cholesterol to total lipids in medium VLDL percentage	MAP4K5 DOCK7 MYRF JMJD1C	1.86e-05	57	81	4	EFO_0022284
Disease	triglycerides to total lipids in medium VLDL percentage	MAP4K5 DOCK7 MYRF JMJD1C	2.77e-05	63	81	4	EFO_0022335
Disease	cholesterol to total lipids in medium VLDL percentage	MAP4K5 DOCK7 MYRF JMJD1C	2.77e-05	63	81	4	EFO_0022239
Disease	cholesteryl esters to total lipids in medium VLDL percentage	MAP4K5 DOCK7 MYRF JMJD1C	2.95e-05	64	81	4	EFO_0022253
Disease	level of Phosphatidylinositol (18:0_20:4) in blood serum	MAP4K5 DOCK7 MYRF	3.39e-05	23	81	3	OBA_2045158
Disease	triglycerides to total lipids in very small VLDL percentage	MAP4K5 DOCK7 MYRF JMJD1C	3.98e-05	69	81	4	EFO_0022341
Disease	free cholesterol to total lipids in large LDL percentage	MAP4K5 DOCK7 MYRF JMJD1C	5.24e-05	74	81	4	EFO_0022280
Disease	monounsaturated fatty acids; 16:1, 18:1 measurement	MAP4K5 DOCK7 MYRF JMJD1C	6.44e-05	78	81	4	EFO_0022187
Disease	Mental Retardation, X-Linked	ZNF711 ZNF41 ZNF81	6.92e-05	29	81	3	C1136249
Disease	cholesteryl esters to total lipids in large LDL percentage	MAP4K5 DOCK7 JMJD1C	8.47e-05	31	81	3	EFO_0022249
Disease	Mental Retardation, X-Linked 1	ZNF711 ZNF41 ZNF81	9.33e-05	32	81	3	C2931498
Disease	apolipoprotein A 1 measurement	TET2 FCGR3B TSHZ2 MAP4K5 GLI1 MAP3K20 DOCK7 MYRF JMJD1C PHIP	1.08e-04	848	81	10	EFO_0004614
Disease	gondoic acid measurement	MAP4K5 MYRF	1.11e-04	6	81	2	EFO_0007975
Disease	triglyceride measurement, physical activity	MAP4K5 DOCK7 JMJD1C	1.12e-04	34	81	3	EFO_0003940, EFO_0004530
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	H2AC1 MAP4K5 DOCK7 BIRC6 MYRF JMJD1C	1.14e-04	276	81	6	EFO_0004612, EFO_0020943
Disease	neuropilin-1 measurement	MAP4K5 DOCK7	1.55e-04	7	81	2	EFO_0020603
Disease	degree of unsaturation measurement	MAP4K5 MYRF JMJD1C	1.70e-04	39	81	3	EFO_0022261
Disease	sleep duration, triglyceride measurement	MAP4K5 DOCK7 MYRF JMJD1C	1.97e-04	104	81	4	EFO_0004530, EFO_0005271
Disease	level of Phosphatidylinositol (16:0_20:4) in blood serum	MAP4K5 MYRF	2.06e-04	8	81	2	OBA_2045154
Disease	coffee consumption measurement, tea consumption measurement	TET2 MAP4K5 JMJD1C	2.43e-04	44	81	3	EFO_0006781, EFO_0010091
Disease	cholesterol to total lipids in large VLDL percentage	MAP4K5 MYRF JMJD1C	2.60e-04	45	81	3	EFO_0022236
Disease	Acute Promyelocytic Leukemia	TET2 GLI1 GLI2	2.78e-04	46	81	3	C0023487
Disease	Gastrointestinal Stromal Sarcoma	GLI1 GLI2 GLI3	2.96e-04	47	81	3	C3179349
Disease	neutrophil count, eosinophil count	TET2 MYO1C FCGR3B MAP4K5 JMJD1C	3.07e-04	213	81	5	EFO_0004833, EFO_0004842
Disease	omega-3 polyunsaturated fatty acid measurement	MAP4K5 DOCK7 MYRF JMJD1C	3.19e-04	118	81	4	EFO_0010119
Disease	level of Phosphatidylcholine (18:0_22:5) in blood serum	MAP4K5 MYRF	3.30e-04	10	81	2	OBA_2045096
Disease	cholesteryl esters to total lipids in small VLDL percentage	MAP4K5 DOCK7 JMJD1C	3.35e-04	49	81	3	EFO_0022256
Disease	Gastrointestinal Stromal Tumors	GLI1 GLI2 GLI3	3.56e-04	50	81	3	C0238198
Disease	depressive symptom measurement, stressful life event measurement	SNCAIP ZCCHC2 METTL4	3.56e-04	50	81	3	EFO_0007006, EFO_0007781
Disease	polyunsaturated fatty acids to total fatty acids percentage	MAP4K5 DOCK7 JMJD1C	3.56e-04	50	81	3	EFO_0022303
Disease	cholesterol to total lipids in small HDL percentage	H2AC1 MAP4K5 DOCK7	3.77e-04	51	81	3	EFO_0022240
Disease	cholesterol to total lipids in small VLDL percentage	MAP4K5 DOCK7 JMJD1C	3.77e-04	51	81	3	EFO_0022242
Disease	phospholipids:total lipids ratio	H2AC1 MAP4K5 DOCK7 MYRF JMJD1C	4.11e-04	227	81	5	EFO_0020946
Disease	docosahexaenoic acid measurement	MAP4K5 DOCK7 MYRF JMJD1C	4.21e-04	127	81	4	EFO_0007761
Disease	triglycerides to total lipids in very large VLDL percentage	MAP4K5 MYRF JMJD1C	4.23e-04	53	81	3	EFO_0022340
Disease	free cholesterol to total lipids in small LDL percentage	MAP4K5 DOCK7 JMJD1C	4.23e-04	53	81	3	EFO_0022286
Disease	mean platelet volume	TET2 UBN1 MYO1C MAP4K5 DOCK7 MECOM PRDM16 KYNU JMJD1C PHIP	4.74e-04	1020	81	10	EFO_0004584
Disease	ceramide measurement	SNCAIP MAP4K5 FHIT PPP1R36 MYRF	4.81e-04	235	81	5	EFO_0010222
Disease	tumor protein p53-inducible protein 11 measurement	MAP4K5 DOCK7	4.83e-04	12	81	2	EFO_0802169
Disease	triglycerides in large VLDL measurement	MAP4K5 DOCK7 JMJD1C	4.97e-04	56	81	3	EFO_0022178
Disease	triglycerides in very large VLDL measurement	MAP4K5 DOCK7 JMJD1C	4.97e-04	56	81	3	EFO_0022325
Disease	triglycerides in chylomicrons and extremely large VLDL measurement	MAP4K5 DOCK7 JMJD1C	4.97e-04	56	81	3	EFO_0022316
Disease	cholesteryl esters to total lipids in large VLDL percentage	MAP4K5 MYRF JMJD1C	4.97e-04	56	81	3	EFO_0022250
Disease	triglycerides to total lipids in small VLDL percentage	MAP4K5 DOCK7 JMJD1C	5.51e-04	58	81	3	EFO_0022338
Disease	Mental Retardation, X-Linked Nonsyndromic	ZNF711 ZNF81	5.69e-04	13	81	2	C3501611
Disease	level of Phosphatidylinositol (18:1_18:1) in blood serum	DOCK7 MYRF	5.69e-04	13	81	2	OBA_2045159
Disease	apolipoprotein E measurement	MAP4K5 DOCK7	5.69e-04	13	81	2	EFO_0008029
Disease	triglycerides in VLDL measurement	MAP4K5 DOCK7 JMJD1C	5.80e-04	59	81	3	EFO_0022326
Disease	triglycerides to total lipids in small LDL percentage	MAP4K5 DOCK7 JMJD1C	5.80e-04	59	81	3	EFO_0022337
Disease	concentration of chylomicrons and extremely large VLDL particles measurement	MAP4K5 DOCK7 JMJD1C	5.80e-04	59	81	3	EFO_0022260
Disease	free cholesterol to total lipids in very large VLDL percentage	MAP4K5 MYRF JMJD1C	5.80e-04	59	81	3	EFO_0022289
Disease	free androgen index	TET2 H2AC1 MAP4K5 FHIT JMJD1C PHIP	5.81e-04	374	81	6	EFO_0007005
Disease	cholesterol in chylomicrons and extremely large VLDL measurement	MAP4K5 DOCK7 JMJD1C	6.09e-04	60	81	3	EFO_0021898
Disease	total lipids in VLDL measurement	MAP4K5 DOCK7 JMJD1C	6.09e-04	60	81	3	EFO_0022314
Disease	glucose measurement	TET2 TSHZ2 MAP4K5 GLI3 MECOM PRDM16	6.31e-04	380	81	6	EFO_0004468
Disease	triglycerides in small VLDL measurement	MAP4K5 DOCK7 JMJD1C	6.39e-04	61	81	3	EFO_0022145
Disease	free cholesterol in very large VLDL measurement	MAP4K5 DOCK7 JMJD1C	6.39e-04	61	81	3	EFO_0022274
Disease	triglycerides in small HDL measurement	MAP4K5 DOCK7 JMJD1C	6.71e-04	62	81	3	EFO_0022158
Disease	phospholipids in large VLDL measurement	MAP4K5 DOCK7 JMJD1C	6.71e-04	62	81	3	EFO_0022169
Disease	triglycerides to total lipids in very large HDL percentage	MAP4K5 DOCK7 JMJD1C	6.71e-04	62	81	3	EFO_0022339
Disease	total lipids in chylomicrons and extremely large VLDL measurement	MAP4K5 DOCK7 JMJD1C	6.71e-04	62	81	3	EFO_0022306
Disease	total lipids in very large VLDL measurement	MAP4K5 DOCK7 JMJD1C	6.71e-04	62	81	3	EFO_0022313
Disease	free cholesterol in chylomicrons and extremely large VLDL measurement	MAP4K5 DOCK7 JMJD1C	6.71e-04	62	81	3	EFO_0022263
Disease	phospholipids in very large VLDL measurement	MAP4K5 DOCK7 JMJD1C	6.71e-04	62	81	3	EFO_0022299
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	H2AC1 MAP4K5 DOCK7 JMJD1C	6.76e-04	144	81	4	EFO_0004611, EFO_0020943
Disease	red blood cell density measurement	TET2 FCGR3B MAP4K5 ZBTB40 ARFGEF2 MECOM HSF2 MYRF JMJD1C	6.86e-04	880	81	9	EFO_0007978
Disease	triglycerides to total lipids in IDL percentage	MAP4K5 DOCK7 JMJD1C	7.03e-04	63	81	3	EFO_0022329
Disease	free cholesterol to total lipids in medium LDL percentage	MAP4K5 DOCK7 JMJD1C	7.03e-04	63	81	3	EFO_0022283
Disease	phospholipids in chylomicrons and extremely large VLDL measurement	MAP4K5 DOCK7 JMJD1C	7.03e-04	63	81	3	EFO_0022292
Disease	liver volume	MAP4K5 JMJD1C	7.64e-04	15	81	2	EFO_0600048
Disease	cholesterol in large VLDL measurement	MAP4K5 DOCK7 JMJD1C	7.70e-04	65	81	3	EFO_0021902
Disease	total lipids in large VLDL	MAP4K5 DOCK7 JMJD1C	8.41e-04	67	81	3	EFO_0022175
Disease	phosphatidylcholine 32:2 measurement	MAP4K5 METTL4	8.71e-04	16	81	2	EFO_0010374
Disease	triglycerides to phosphoglycerides ratio	MAP4K5 DOCK7 JMJD1C	8.78e-04	68	81	3	EFO_0022327
Disease	free cholesterol in large VLDL measurement	MAP4K5 DOCK7 JMJD1C	8.78e-04	68	81	3	EFO_0022265
Disease	pre-malignant neoplasm (biomarker_via_orthology)	GLI1 GLI3	9.85e-04	17	81	2	DOID:0060071 (biomarker_via_orthology)
Disease	triglycerides to total lipids in small HDL percentage	MAP4K5 DOCK7 JMJD1C	1.04e-03	72	81	3	EFO_0022336
Disease	asthma	FLG THEMIS GLI3 MECOM PRDM16 MYRF KYNU JMJD1C	1.06e-03	751	81	8	MONDO_0004979
Disease	myeloid white cell count	TET2 MYO1C FCGR3B MAP4K5 MECOM ZCCHC2 HSF2 ZNF282 JMJD1C	1.07e-03	937	81	9	EFO_0007988
Disease	level of Phosphatidylinositol (18:0_18:1) in blood serum	DOCK7 MYRF	1.11e-03	18	81	2	OBA_2045155
Disease	free cholesterol to total lipids in small VLDL percentage	MAP4K5 DOCK7 JMJD1C	1.17e-03	75	81	3	EFO_0022287
Disease	bilirubin measurement	MAP4K5 GLI2 DOCK7 BIRC6 JMJD1C PHIP	1.38e-03	442	81	6	EFO_0004570
Disease	free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	H2AC1 MAP4K5 GLI1 DOCK7 BIRC6	1.50e-03	303	81	5	EFO_0004612, EFO_0020945
Disease	prothrombin time measurement	MAP4K5 JMJD1C	1.51e-03	21	81	2	EFO_0008390
Disease	docosahexaenoic acid to total fatty acids percentage	MYRF JMJD1C	1.51e-03	21	81	2	EFO_0022262
Disease	level of Phosphatidylcholine (16:1_18:2) in blood serum	MAP4K5 MYRF	1.51e-03	21	81	2	OBA_2045083
Disease	coffee consumption measurement	TET2 MAP4K5 BIRC6 HYDIN	1.61e-03	182	81	4	EFO_0006781
Disease	phosphatidylcholine 34:3 measurement	MAP4K5 METTL4	1.66e-03	22	81	2	EFO_0010377
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	H2AC1 MAP4K5 DOCK7	1.73e-03	86	81	3	EFO_0008595, EFO_0020945
Disease	fasting blood glucose measurement, HOMA-B, fasting blood insulin measurement	MAP4K5 MYRF	2.14e-03	25	81	2	EFO_0004465, EFO_0004466, EFO_0004469
Disease	aggressive behavior	ABAT ARFGEF2	2.14e-03	25	81	2	EFO_0003015
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement	MAP4K5 DOCK7 JMJD1C	2.30e-03	95	81	3	EFO_0004529, EFO_0008317, EFO_0008596
Disease	diet measurement	ZNF585A MAP4K5 ARFGEF2 ZCCHC2 FHIT PRDM16 ZNF714 JMJD1C ZNF585B	2.31e-03	1049	81	9	EFO_0008111
Disease	unipolar depression, depressive symptom measurement	ARFGEF2 FHIT	2.32e-03	26	81	2	EFO_0003761, EFO_0007006
Disease	chylomicron measurement, triglyceride measurement, very low density lipoprotein cholesterol measurement	MAP4K5 DOCK7 JMJD1C	2.37e-03	96	81	3	EFO_0004530, EFO_0008317, EFO_0008596

Protein segments in the cluster

Peptide	Gene	Start	Entry
KHPHHLSLKEEASDV	EPC2	316	Q52LR7
CIIPHVHSKDKSHIP	BDP1	2011	A6H8Y1
HKVAKWATVTFHLPH	BIRC6	211	Q9NR09
FHLPHHVLKSIASAI	BIRC6	221	Q9NR09
KTQHHSHPAKSLVEQ	BAZ2B	576	Q9UIF8
HSSLHAAPAKPDHKE	AFF2	816	P51816
HAKAPFTSATHLDHV	ARFGEF2	876	Q9Y6D5
KENLPISGHKHRKHS	FLG	91	P20930
DLPVHTRTLKGHKHE	CEP170B	341	Q9Y4F5
EIKHEEKPGKSIHHS	C2orf73	26	Q8N5S3
SGLKQHKHIHSSVKP	MECOM	361	Q03112
HKHIHSSVKPFICEV	MECOM	366	Q03112
KHVKTVHGPEAHVTK	GLI3	626	P10071
HSSPPLTKTLVDHHK	JMJD1C	941	Q15652
ATTHSKAIHKIDIPS	ABAT	226	P80404
HHFAKHKSPLVVILI	OR51A7	261	Q8NH64
DPISSKHIKTLSEAH	DCAF10	196	Q5QP82
KHVKTVHGPDAHVTK	GLI1	381	P08151
LRKHVKTVHGPDAHV	GLI2	581	P10070
IKHFPKHVADLHASS	PTPRZ1	1701	P23471
AVVKSPHIHHKTTAL	LRRC70	416	Q7Z2Q7
HSPAKHASAFIHADI	MEI1	311	Q5TIA1
AKASITSKRHIPEAH	BOD1L1	1356	Q8NFC6
TVKHVHVHVLPRKAG	FHIT	91	P49789
ESPIHQKKAASHVRH	HYDIN	3211	Q4G0P3
TKVFSTEPHHSEHKL	ICE1	661	Q9Y2F5
TEPHHSEHKLQTKTL	ICE1	666	Q9Y2F5
EIKVKLPATLTDHHH	DOCK7	631	Q96N67
KTPHKSEIHAHLHTP	GCNT7	71	Q6ZNI0
KLSELERPHKVSHGH	ELOA	161	Q14241
HNILPKTLANDKHSH	CENPC	351	Q03188
HSKSHQKSHPVIEHC	DYTN	261	A2CJ06
HSSVFHHSVKAPKED	PIK3CD-AS1	131	Q5SR53
SHFKHIIHGLLPAAS	CEP89	11	Q96ST8
HIIHFKSAIEKLTHD	MAP3K20	396	Q9NYL2
FHHNSDFHIPKATLK	FCGR3B	151	O75015
TVHFKSLSDTAKPHI	KLF10	116	Q13118
VHFIDKVTDKPSHSH	ARRDC1-AS1	41	Q9H2J1
THTLALAAKHHSTPL	EIF2B2	251	P49770
LLPKKTESHHHKAQS	H2AC1	116	Q96QV6
LVPRFHADFIHKHVK	BPHL	246	Q86WA6
HKLIVSVPCTLHSHK	METTL4	406	Q8N3J2
PEKSINKIGHALHAH	PHYHD1	96	Q5SRE7
ALHAHDPVFKSITHS	PHYHD1	106	Q5SRE7
HAKKPGLAAHIQTHR	MAP4K5	586	Q9Y4K4
IVKEPTDNHHHKVPH	HSF2	216	Q03933
KVNNIHPAVHTKTDH	UTY	746	O14607
HLPREVSPKKHSTVH	MAP3K21	926	Q5TCX8
RPCHETTVDIFHKKH	MITD1	231	Q8WV92
LKQHKHIHSTVKPFI	PRDM16	381	Q9HAZ2
PHLRKASAVIHDQHK	SNCAIP	216	Q9Y6H5
AVEHKAKKSLSHPSH	SPTY2D1	336	Q68D10
QHAIIHKKHTGKSPI	ZCCHC2	501	Q9C0B9
HVVATKAFHSPHDKL	THEMIS	366	Q8N1K5
HLTTHKILHTGEKPY	ZNF93	551	P35789
SLVKHQRIHTGEKPH	ZNF189	246	O75820
AFKQASHLTIHKIIH	ZNF107	196	Q9UII5
SHLTIHKIIHTGEKP	ZNF107	201	Q9UII5
SHLTKHKTIHAGEKP	ZNF738	301	Q8NE65
HSKSHTETKPHKCPH	ZNF384	246	Q8TF68
NHPSALTTHKFIHVK	ZNF714	266	Q96N38
LIIHHSTHTGKKPHE	ZNF182	361	P17025
LKIHLDFKHSADLPH	ZNF639	446	Q9UID6
SLVIHKAIHTGEKPH	ZNF702P	76	Q9H963
NKIPTVSKNHAHEHF	PHIP	766	Q8WWQ0
TLKEHLRIHSGEKPH	ZBTB41	561	Q5SVQ8
SQLHVHKRIHTGEKP	ZNF585B	451	Q52M93
LKHHPHFTPAAEVKE	PPP1R36	56	Q96LQ0
LHLSKTHSKSPEHHS	TSHZ2	1011	Q9NRE2
SQLHVHKRIHTGEKP	ZNF585A	451	Q6P3V2
HLTTHKIIHTGEKPY	ZNF430	331	Q9H8G1
EKHLSHKQAPTHHQK	ZNF41	291	P51814
SHHLKTKHSELENKP	ZMYM6	786	O95789
TTLNKHHKVHTAERP	ZNF416	451	Q9BWM5
KGLPEVHQSKAKHHS	UBN1	771	Q9NPG3
VHQSKAKHHSLPRTS	UBN1	776	Q9NPG3
FHRPSELKKHVAAHK	ZFX	671	P17010
SHLTTHKIIHTGKKP	ZNF98	251	A6NK75
FKHSSPLSKHKRIHT	ZNF66	406	Q6ZN08
AFKHPSGLTLHKRIH	ZNF355P	136	Q9NSJ1
KTFHHNSALVIHKAI	ZNF860	461	A6NHJ4
SLEDPKSITHHKLIH	UBAC1	51	Q9BSL1
SHLARHQKIHTGEKP	ZNF766	396	Q5HY98
RHSISHSELKPHQCK	ZNF524	131	Q96C55
KIHETVAKHPAVCSH	ZNF732	66	B4DXR9
SSLLIHHAVHTGEKP	ZNF239	276	Q16600
KRHIISVHTKDFPHK	ZNF711	606	Q9Y462
PSHQVHFSKTDHLPK	TET2	656	Q6N021
HFSKTDHLPKAHVQS	TET2	661	Q6N021
AGLFHHIKIHTRDKP	ZSCAN12	371	O43309
FNHPATLFSHKKIHT	ZNF506	266	Q5JVG8
KSLIIHHRSHTKERP	ZNF282	531	Q9UDV7
FSKKPHLKVHQRIHT	ZNF81	591	P51508
PNTIEHKKHIKAEHA	ZBTB40	1056	Q9NUA8
GFHRPSELKKHVAVH	ZFY	666	P08048
AFKHPSVLTTHKRIH	ZNF737	321	O75373
AGAFIHEKHAHTIKP	KYNU	286	Q16719
TVKHHPHFLTHKLAD	MYO1C	516	O00159
AVHQKHKDHFRLTIP	MYO6	546	Q9UM54
IGHSKHHKSLEPLAS	MYRF	946	Q9Y2G1