Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	semaphorin receptor binding	SEMA3A SEMA3G SEMA3B	1.60e-05	23	43	3	GO:0030215
GeneOntologyMolecularFunction	chemorepellent activity	SEMA3A SEMA3G SEMA3B	3.27e-05	29	43	3	GO:0045499
GeneOntologyBiologicalProcess	stem cell differentiation	SEMA3A CHD4 SEMA3G EZH2 PHF5A DNMT3L SEMA3B	2.55e-06	306	42	7	GO:0048863
GeneOntologyBiologicalProcess	semaphorin-plexin signaling pathway	SEMA3A ERBB2 SEMA3G SEMA3B	3.74e-06	52	42	4	GO:0071526
GeneOntologyCellularComponent	CHD-type complex	CHD4 CHD5	5.51e-04	17	43	2	GO:0090545
GeneOntologyCellularComponent	ESC/E(Z) complex	EZH2 DNMT3L	5.51e-04	17	43	2	GO:0035098
GeneOntologyCellularComponent	NuRD complex	CHD4 CHD5	5.51e-04	17	43	2	GO:0016581
MousePheno	fetal bleb	FRAS1 CRIM1	3.86e-05	4	36	2	MP:0008856
MousePheno	abnormal glomerular capsule space morphology	PJA2 FRAS1 CRIM1	4.40e-05	27	36	3	MP:0011499
Domain	VWC_out	MUC19 FRAS1 VWF CRIM1 OTOG	5.77e-10	19	43	5	SM00215
Domain	VWF_dom	MUC19 FRAS1 VWF CRIM1 OTOG	4.06e-08	42	43	5	IPR001007
Domain	CT	MUC19 CCN6 VWF OTOG	1.73e-07	22	43	4	SM00041
Domain	Cys_knot_C	MUC19 CCN6 VWF OTOG	2.97e-07	25	43	4	IPR006207
Domain	CTCK_2	MUC19 CCN6 VWF OTOG	2.97e-07	25	43	4	PS01225
Domain	VWC	MUC19 FRAS1 VWF CRIM1	1.70e-06	38	43	4	SM00214
Domain	VWFC_2	MUC19 FRAS1 VWF CRIM1	1.70e-06	38	43	4	PS50184
Domain	TIL	MUC19 VWF OTOG	2.46e-06	12	43	3	PF01826
Domain	C8	MUC19 VWF OTOG	2.46e-06	12	43	3	PF08742
Domain	PSI	SEMA3A SEMA3G ITGB5 SEMA3B	3.09e-06	44	43	4	IPR016201
Domain	Unchr_dom_Cys-rich	MUC19 VWF OTOG	3.20e-06	13	43	3	IPR014853
Domain	C8	MUC19 VWF OTOG	3.20e-06	13	43	3	SM00832
Domain	PSI	SEMA3A SEMA3G ITGB5 SEMA3B	3.70e-06	46	43	4	SM00423
Domain	TIL_dom	MUC19 VWF OTOG	4.07e-06	14	43	3	IPR002919
Domain	VWD	MUC19 VWF OTOG	6.23e-06	16	43	3	SM00216
Domain	VWF_type-D	MUC19 VWF OTOG	6.23e-06	16	43	3	IPR001846
Domain	VWFD	MUC19 VWF OTOG	6.23e-06	16	43	3	PS51233
Domain	VWD	MUC19 VWF OTOG	6.23e-06	16	43	3	PF00094
Domain	Znf_RING	PJA2 RNF186 CHD4 GTF2H2 RBBP6 RCHY1 CHD5	8.69e-06	326	43	7	IPR001841
Domain	CTCK_1	MUC19 CCN6 VWF	9.05e-06	18	43	3	PS01185
Domain	Semaphorin	SEMA3A SEMA3G SEMA3B	1.26e-05	20	43	3	IPR027231
Domain	CHDCT2	CHD4 CHD5	1.55e-05	3	43	2	PF08074
Domain	CHDNT	CHD4 CHD5	1.55e-05	3	43	2	PF08073
Domain	DUF1086	CHD4 CHD5	1.55e-05	3	43	2	IPR009462
Domain	DUF1087	CHD4 CHD5	1.55e-05	3	43	2	IPR009463
Domain	CHD_N	CHD4 CHD5	1.55e-05	3	43	2	IPR012958
Domain	CHD_C2	CHD4 CHD5	1.55e-05	3	43	2	IPR012957
Domain	DUF1087	CHD4 CHD5	1.55e-05	3	43	2	PF06465
Domain	DUF1086	CHD4 CHD5	1.55e-05	3	43	2	PF06461
Domain	DUF1087	CHD4 CHD5	1.55e-05	3	43	2	SM01147
Domain	DUF1086	CHD4 CHD5	1.55e-05	3	43	2	SM01146
Domain	-	COL6A2 GTF2H2 VWF ITGB5	2.49e-05	74	43	4	3.40.50.410
Domain	Growth_fac_rcpt_	CCN6 ERBB2 FRAS1 CRIM1 NOTCH3	2.84e-05	156	43	5	IPR009030
Domain	VWC	FRAS1 VWF CRIM1	3.58e-05	28	43	3	PF00093
Domain	VWFA	COL6A2 GTF2H2 VWF ITGB5	3.74e-05	82	43	4	PS50234
Domain	VWA	COL6A2 GTF2H2 VWF ITGB5	4.11e-05	84	43	4	SM00327
Domain	Sema	SEMA3A SEMA3G SEMA3B	4.88e-05	31	43	3	SM00630
Domain	Semap_dom	SEMA3A SEMA3G SEMA3B	4.88e-05	31	43	3	IPR001627
Domain	Sema	SEMA3A SEMA3G SEMA3B	4.88e-05	31	43	3	PF01403
Domain	SEMA	SEMA3A SEMA3G SEMA3B	4.88e-05	31	43	3	PS51004
Domain	RING	PJA2 RNF186 CHD4 RBBP6 RCHY1 CHD5	6.62e-05	305	43	6	SM00184
Domain	-	PJA2 RNF186 CHD4 RBBP6 RCHY1 CHD5 DNMT3L	6.75e-05	449	43	7	3.30.40.10
Domain	VWFC_1	FRAS1 VWF CRIM1	7.70e-05	36	43	3	PS01208
Domain	Znf_RING/FYVE/PHD	PJA2 RNF186 CHD4 RBBP6 RCHY1 CHD5 DNMT3L	7.75e-05	459	43	7	IPR013083
Domain	VWF_A	COL6A2 GTF2H2 VWF ITGB5	7.82e-05	99	43	4	IPR002035
Domain	Furin_repeat	ERBB2 FRAS1	7.74e-04	18	43	2	IPR006212
Domain	FU	ERBB2 FRAS1	7.74e-04	18	43	2	SM00261
Domain	IB	CCN6 CRIM1	7.74e-04	18	43	2	SM00121
Domain	ig	SEMA3A SEMA3G GPA33 SEMA3B	9.39e-04	190	43	4	PF00047
Domain	Immunoglobulin	SEMA3A SEMA3G GPA33 SEMA3B	9.39e-04	190	43	4	IPR013151
Domain	IGFBP-like	CCN6 CRIM1	9.58e-04	20	43	2	IPR000867
Domain	IGFBP	CCN6 CRIM1	9.58e-04	20	43	2	PF00219
Domain	IGFBP_N_2	CCN6 CRIM1	9.58e-04	20	43	2	PS51323
Domain	Chromo_domain	CHD4 CHD5	1.38e-03	24	43	2	IPR023780
Domain	Chromo	CHD4 CHD5	1.62e-03	26	43	2	PF00385
Domain	CHROMO_1	CHD4 CHD5	1.88e-03	28	43	2	PS00598
Domain	CHROMO_2	CHD4 CHD5	1.88e-03	28	43	2	PS50013
Domain	EGF	FRAS1 ITGB5 NOTCH3 SORL1	2.05e-03	235	43	4	SM00181
Domain	SNF2_N	CHD4 CHD5	2.46e-03	32	43	2	IPR000330
Domain	PSI	SEMA3G SEMA3B	2.46e-03	32	43	2	PF01437
Domain	Chromodomain-like	CHD4 CHD5	2.46e-03	32	43	2	IPR016197
Domain	SNF2_N	CHD4 CHD5	2.46e-03	32	43	2	PF00176
Domain	Plexin_repeat	SEMA3G SEMA3B	2.46e-03	32	43	2	IPR002165
Domain	EGF-like_dom	FRAS1 NOTCH3 OTOG SORL1	2.53e-03	249	43	4	IPR000742
Domain	Chromo/shadow_dom	CHD4 CHD5	2.61e-03	33	43	2	IPR000953
Domain	CHROMO	CHD4 CHD5	2.61e-03	33	43	2	SM00298
Pathway	WP_FOCAL_ADHESION	COL6A2 ERBB2 VWF VEGFD ITGB5	5.86e-05	187	32	5	MM15913
Pathway	WP_FOCAL_ADHESION	COL6A2 ERBB2 VWF VEGFD ITGB5	7.87e-05	199	32	5	M39402
Pathway	KEGG_FOCAL_ADHESION	COL6A2 ERBB2 VWF VEGFD ITGB5	7.87e-05	199	32	5	M7253
Pubmed	Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting.	SEMA3A SEMA3G SEMA3B	4.12e-07	12	44	3	19812329
Pubmed	Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.	SEMA3A SEMA3G SEMA3B	4.12e-07	12	44	3	23991118
Pubmed	DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.	CHD4 EZH2 CHD5	8.50e-07	15	44	3	35695185
Pubmed	Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.	ERBB2 NOTCH3	1.56e-06	2	44	2	21743488
Pubmed	NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells.	ERBB2 NOTCH3	1.56e-06	2	44	2	18339869
Pubmed	Mutual regulation between CHD5 and EZH2 in hepatocellular carcinoma.	EZH2 CHD5	1.56e-06	2	44	2	26517514
Pubmed	Expressions of EZH2 and NOTCH3 pathway in osteosarcoma and their roles in osteosarcoma stem cells.	EZH2 NOTCH3	1.56e-06	2	44	2	36946271
Pubmed	Reciprocal modulation of Cav 2.3 voltage-gated calcium channels by copper(II) ions and kainic acid.	SEMA3G SEMA3B	1.56e-06	2	44	2	29972687
Pubmed	CHD4 mediates proliferation and migration of non-small cell lung cancer via the RhoA/ROCK pathway by regulating PHF5A.	CHD4 PHF5A	1.56e-06	2	44	2	32228507
Pubmed	Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation.	CHD4 EZH2	1.56e-06	2	44	2	38461299
Pubmed	Sall1 balances self-renewal and differentiation of renal progenitor cells.	SEMA3A FRAS1 VEGFD RXFP2	1.61e-06	67	44	4	24550112
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SEMA3A TCTN3 ERBB2 FRAS1 CRIM1 ITGB5 SQSTM1 NOTCH3 SORL1 SEMA3B	1.98e-06	1201	44	10	35696571
Pubmed	Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity.	SEMA3A SEMA3G SEMA3B	2.47e-06	21	44	3	36240771
Pubmed	EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy.	ERBB2 EZH2	4.69e-06	3	44	2	33208750
Pubmed	A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance.	ERBB2 SORL1	4.69e-06	3	44	2	33420373
Pubmed	The predictive value of semaphorins 3 expression in biopsies for biochemical recurrence of patients with low- and intermediate-risk prostate cancer.	SEMA3A SEMA3B	4.69e-06	3	44	2	23906303
Pubmed	The role of the plexin-A2 receptor in Sema3A and Sema3B signal transduction.	SEMA3A SEMA3B	4.69e-06	3	44	2	25335892
Pubmed	Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels.	SEMA3A SEMA3G SEMA3B	8.28e-06	31	44	3	22076636
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PJA2 ERBB2 CHD4 ZNHIT6 RBBP6 PHF5A SQSTM1 CHD5 SORL1	9.00e-06	1116	44	9	31753913
Pubmed	EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients.	CHD4 EZH2	9.37e-06	4	44	2	29272522
Pubmed	Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance.	SEMA3A SEMA3B	9.37e-06	4	44	2	10985345
Pubmed	Expression Levels of Semaphorins 3A, 3B, 4A, and 4D on Human Peri-implantitis.	SEMA3A SEMA3B	9.37e-06	4	44	2	29763494
Pubmed	Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors.	SEMA3A SEMA3B	9.37e-06	4	44	2	10196546
Pubmed	CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.	CHD4 EZH2	9.37e-06	4	44	2	28486105
Pubmed	Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs.	EZH2 DNMT3L	1.56e-05	5	44	2	24074865
Pubmed	Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells.	SEMA3A SEMA3G	1.56e-05	5	44	2	18818766
Pubmed	The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.	CHD4 EZH2	1.56e-05	5	44	2	23624931
Pubmed	Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling.	ERBB2 ACVR2A	1.56e-05	5	44	2	28650473
Pubmed	A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis.	SEMA3A SEMA3B	1.56e-05	5	44	2	8817451
Pubmed	Expression of class 3 semaphorins and neuropilin receptors in the developing mouse tooth.	SEMA3A SEMA3B	2.34e-05	6	44	2	11231073
Pubmed	Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension.	SEMA3A SEMA3B	2.34e-05	6	44	2	7748561
Pubmed	An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.	SEMA3A SEMA3G SEMA3B	4.00e-05	52	44	3	26633812
Pubmed	Semaphorins III and IV repel hippocampal axons via two distinct receptors.	SEMA3A SEMA3B	4.36e-05	8	44	2	9753685
Pubmed	Development of the somatosensory cortex, the cerebellum, and the main olfactory system in Semaphorin 3F knockout mice.	SEMA3G SEMA3B	4.36e-05	8	44	2	20006658
Pubmed	Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons.	SEMA3A SEMA3B	4.36e-05	8	44	2	11906695
Pubmed	Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice.	COL6A2 FRAS1	4.36e-05	8	44	2	12766770
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	TCTN3 FRAS1 ITGB5 SORL1	5.59e-05	164	44	4	32409323
Pubmed	The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins.	SEMA3A SEMA3B	5.60e-05	9	44	2	8812066
Pubmed	Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.	ERBB2 SORL1	5.60e-05	9	44	2	32601248
Pubmed	The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.	COL6A2 FRAS1	6.99e-05	10	44	2	15345741
Pubmed	Class 3 semaphorins negatively regulate dermal lymphatic network formation.	SEMA3G SEMA3B	8.54e-05	11	44	2	26319580
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	SEMA3A ERBB2 EZH2 RBBP6 NOTCH3	8.78e-05	358	44	5	32460013
Pubmed	Functional proteomics mapping of a human signaling pathway.	ZNHIT6 VWF CSRNP2 XPO5 RBBP6 ZNF587B	9.57e-05	591	44	6	15231748
Pubmed	CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression.	EZH2 CHD5	1.21e-04	13	44	2	23948251
Pubmed	Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.	VWF NOTCH3	1.21e-04	13	44	2	20558824
Pubmed	Defining brain wiring patterns and mechanisms through gene trapping in mice.	CRIM1 NOTCH3	1.41e-04	14	44	2	11242070
Pubmed	The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.	SEMA3A SEMA3B	1.41e-04	14	44	2	22955271
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	CRIM1 ITGB5 SQSTM1 NOTCH3	1.56e-04	214	44	4	22199357
Pubmed	The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.	CHD4 CHD5	1.63e-04	15	44	2	25247294
Pubmed	Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.	SEMA3A SEMA3B	1.86e-04	16	44	2	22632726
Pubmed	Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.	SEMA3A SEMA3B	1.86e-04	16	44	2	18489001
Pubmed	Balance between BDNF and Semaphorins gates the innervation of the mammary gland.	SEMA3A SEMA3B	1.86e-04	16	44	2	30628891
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	COL6A2 FRAS1	1.86e-04	16	44	2	16880404
Pubmed	Semaphorin signaling facilitates cleft formation in the developing salivary gland.	SEMA3A SEMA3B	2.10e-04	17	44	2	17626059
Pubmed	A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.	CHD4 CHD5	2.10e-04	17	44	2	27806305
Pubmed	An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.	CHD4 CHD5 DNMT3L	2.12e-04	91	44	3	20362542
Pubmed	TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.	CHD4 EZH2	2.36e-04	18	44	2	28068325
Pubmed	PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.	SEMA3A VWF	2.64e-04	19	44	2	15239958
Pubmed	Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stage.	SEMA3A SEMA3B	2.64e-04	19	44	2	15051154
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	SEMA3A COL6A2 VWF VEGFD	2.74e-04	248	44	4	24006456
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	ERBB2 ITGB5 NOTCH3	2.89e-04	101	44	3	23382219
Pubmed	VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm.	SEMA3A SEMA3B	2.93e-04	20	44	2	21658587
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	CHD4 RBBP6 CHD5	3.06e-04	103	44	3	32744500
Pubmed	The DNA sequence of human chromosome 21.	COL6A2 LIPI KRTAP10-1 DNMT3L	3.18e-04	258	44	4	10830953
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TCTN3 ERBB2 ACVR2A CRIM1 XPO5 PIP4P2 NOTCH3	3.45e-04	1061	44	7	33845483
Pubmed	The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart.	SEMA3A NOTCH3	3.56e-04	22	44	2	36877136
Pubmed	Decoding the fine-scale structure of a breast cancer genome and transcriptome.	ACVR2A RCHY1	3.89e-04	23	44	2	16461635
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	CHD4 VWF ITGB5 ZNF181 NOTCH3	4.01e-04	497	44	5	23414517
Pubmed	Hemodynamic force is required for vascular smooth muscle cell recruitment to blood vessels during mouse embryonic development.	SEMA3A SEMA3G	4.24e-04	24	44	2	30796970
Pubmed	A semaphorin code defines subpopulations of spinal motor neurons during mouse development.	SEMA3A SEMA3B	4.24e-04	24	44	2	15869472
Pubmed	GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation.	NOTCH3 RXFP2	4.24e-04	24	44	2	32497091
Pubmed	Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS.	ERBB2 SQSTM1	4.24e-04	24	44	2	26115514
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	SEMA3A SEMA3G SEMA3B	4.44e-04	117	44	3	17145500
Pubmed	Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription.	GTF2H2 SQSTM1	4.61e-04	25	44	2	9184228
Pubmed	Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.	SEMA3A CRIM1 SEMA3B	5.52e-04	126	44	3	16284245
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	CHD4 ZNHIT6 PHF5A SQSTM1	5.61e-04	300	44	4	28561026
Pubmed	Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.	SEMA3A SEMA3B	5.79e-04	28	44	2	18617019
Pubmed	Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development.	SEMA3A ERBB2	5.79e-04	28	44	2	37846569
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	CHD4 XPO5 NOTCH3	5.91e-04	129	44	3	23022380
Pubmed	Noggin is required for correct guidance of dorsal root ganglion axons.	SEMA3A SEMA3B	6.21e-04	29	44	2	12435358
Pubmed	Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex.	CHD4 SORL1	6.65e-04	30	44	2	18055048
Pubmed	TBX1 is required for normal stria vascularis and semicircular canal development.	NOTCH3 OTOG	7.11e-04	31	44	2	31550482
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	CHD4 EZH2 PHF5A CHD5	8.01e-04	330	44	4	33301849
Pubmed	Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation.	SEMA3A SEMA3B	8.06e-04	33	44	2	26830346
Pubmed	Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex.	CRIM1 SORL1	8.06e-04	33	44	2	27100196
Pubmed	The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.	CHD4 SQSTM1 CHD5	8.63e-04	147	44	3	28977470
Pubmed	Identification of the BRD1 interaction network and its impact on mental disorder risk.	CHD4 CHD5	9.06e-04	35	44	2	27142060
Pubmed	A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation.	CHD4 CHD5	9.59e-04	36	44	2	29089422
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	COL6A2 VWF SEMA3B	9.69e-04	153	44	3	25037231
Pubmed	Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.	SQSTM1 SORL1	1.01e-03	37	44	2	24162737
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	CHD4 CHD5	1.07e-03	38	44	2	33283408
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	COL6A2 FRAS1 VWF	1.25e-03	167	44	3	22159717
Interaction	CCN6 interactions	CCN6 COL6A2 FRAS1 SORL1	7.48e-08	19	44	4	int:CCN6
Interaction	NRP2 interactions	SEMA3A SEMA3G EZH2 SEMA3B	8.24e-06	59	44	4	int:NRP2
Interaction	NTN5 interactions	FRAS1 NOTCH3 SORL1	1.90e-05	24	44	3	int:NTN5
Interaction	SIRPD interactions	COL6A2 FRAS1 SORL1 SEMA3B	3.68e-05	86	44	4	int:SIRPD
Cytoband	21q22.3	COL6A2 KRTAP10-1 DNMT3L	2.58e-04	128	44	3	21q22.3
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA3A SEMA3G SEMA3B	8.78e-06	20	37	3	736
GeneFamily	PHD finger proteins\|NuRD complex	CHD4 CHD5	2.66e-04	12	37	2	1305
GeneFamily	Immunoglobulin like domain containing	SEMA3A SEMA3G GPA33 SEMA3B	6.31e-04	193	37	4	594
GeneFamily	PHD finger proteins	CHD4 PHF5A CHD5	8.20e-04	90	37	3	88
GeneFamily	Ring finger proteins	PJA2 RNF186 RCHY1	1.85e-02	275	37	3	58
Coexpression	NABA_MATRISOME	SEMA3A MUC19 CCN6 COL6A2 FRAS1 SEMA3G VWF CRIM1 VEGFD WFIKKN2 OTOG SEMA3B	6.63e-08	1008	44	12	MM17056
Coexpression	NABA_MATRISOME	SEMA3A MUC19 CCN6 COL6A2 FRAS1 SEMA3G VWF CRIM1 VEGFD WFIKKN2 OTOG SEMA3B	8.04e-08	1026	44	12	M5889
Coexpression	NABA_CORE_MATRISOME	CCN6 COL6A2 FRAS1 VWF CRIM1 OTOG	5.74e-06	270	44	6	MM17057
Coexpression	NABA_CORE_MATRISOME	CCN6 COL6A2 FRAS1 VWF CRIM1 OTOG	6.38e-06	275	44	6	M5884
Coexpression	DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN	ERBB2 CHD4 RBBP6 ITGB5 NOTCH3 SORL1	6.51e-06	276	44	6	M3063
Coexpression	NABA_ECM_GLYCOPROTEINS	CCN6 FRAS1 VWF CRIM1 OTOG	1.68e-05	191	44	5	MM17059
Coexpression	NABA_ECM_GLYCOPROTEINS	CCN6 FRAS1 VWF CRIM1 OTOG	1.90e-05	196	44	5	M3008
Coexpression	GSE360_L_DONOVANI_VS_L_MAJOR_DC_DN	COL6A2 VWF CRIM1 VEGFD CHD5	1.90e-05	196	44	5	M5194
Coexpression	GSE21360_PRIMARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN	ZNF814 PJA2 CSRNP2 SQSTM1 SORL1	2.00e-05	198	44	5	M7610
Coexpression	GSE7568_IL4_VS_IL4_AND_DEXAMETHASONE_TREATED_MACROPHAGE_DN	TCTN3 ACVR2A CRIM1 SORL1	1.20e-04	151	44	4	M369
Coexpression	NABA_ECM_AFFILIATED	SEMA3A MUC19 SEMA3G SEMA3B	1.43e-04	158	44	4	MM17063
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PROSER2 SEMA3G VWF CRIM1 VEGFD	1.38e-06	195	44	5	4658fb197657d7692ee344ae76b11b0210c418ba
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DLG3 FRAS1 PHF5A WFIKKN2	1.74e-05	157	44	4	ffb8dd381e6b9adc5283fb49586e8bd63773c8d6
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DLG3 FRAS1 PHF5A WFIKKN2	1.74e-05	157	44	4	c488ab1d6c6c7e5c2f4426805d1366b44711a031
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A MUC19 FRAS1 RXFP2	1.87e-05	160	44	4	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A MUC19 FRAS1 RXFP2	1.87e-05	160	44	4	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CRIM1 LIPI CHD5 NOTCH3	2.01e-05	163	44	4	51dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3G ACVR2A CHD5 SORL1	2.32e-05	169	44	4	4e1322cc5e1733e9fb19e08f739a30206f43cea8
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ERBB2 FRAS1 PROSER2 SEMA3B	3.03e-05	181	44	4	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA3A COL6A2 CRIM1 NOTCH3	3.23e-05	184	44	4	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	facs-Kidney-nan-3m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 PROSER2 VEGFD NOTCH3	3.59e-05	189	44	4	a5306561026e4dfcc39beeb785e5108ac595d136
ToppCell	facs-Kidney-nan-3m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 PROSER2 VEGFD NOTCH3	3.59e-05	189	44	4	302b950a6ad578f8aeff7ea6fd15fe631225287d
ToppCell	facs-Kidney-nan-3m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 PROSER2 VEGFD NOTCH3	3.59e-05	189	44	4	381058f55908f84375b54601d617389ef43ab855
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	SEMA3A VEGFD ITGB5 DNMT3L	3.74e-05	191	44	4	5ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A COL6A2 ITGB5 SEMA3B	3.82e-05	192	44	4	b35f0e422070ba9c7c1d9ff3eace4edc10286cde
ToppCell	ASK452-Endothelial-Lymphatic\|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq	SEMA3A PJA2 ACVR2A XPO5	4.06e-05	195	44	4	20f492299a684ac1b7dd1bbc36a533cd6f9a1c93
ToppCell	Control-PLT_1\|Control / Disease Group and Platelet Clusters	PROSER2 PIP4P2 RBBP6 SQSTM1	4.06e-05	195	44	4	20ee45983a5675d9fa072d02dd45c6ce8662d7d7
ToppCell	(3)_Chondrocytes-(34)_Chondro-progen\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	COL6A2 PROSER2 ZNHIT6 CRIM1	4.06e-05	195	44	4	d00cb2fab25f2026a9668a7f0686938a2e7155e2
ToppCell	Bronchial_Biopsy-Mesenchymal-Smooth_muscle\|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X	SEMA3G VWF CRIM1 NOTCH3	4.22e-05	197	44	4	98f0184a09563a544f0c2d4df22c9db2fbc95019
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PROSER2 SEMA3G VWF CRIM1	4.30e-05	198	44	4	218f33e068eb126458ec33176de3cfa6fc06ddf0
ToppCell	Transplant_Alveoli_and_parenchyma-Endothelial\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	SEMA3A SEMA3G VWF CRIM1	4.30e-05	198	44	4	56b746e5791b47fe33a7872f0942ae0747b13d4a
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PROSER2 SEMA3G VWF CRIM1	4.30e-05	198	44	4	7cddd474416651088a4e08edfc0ac420ff10a5fe
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PROSER2 SEMA3G VWF CRIM1	4.30e-05	198	44	4	e1fa02184ce93c4f8aa5cf04b70949cd4c425ff0
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A COL6A2 ITGB5 SEMA3B	4.39e-05	199	44	4	edd5300da1a3b758210ff8f949e9d1988b8bc7e2
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Intermediate\|6m / Sample Type, Dataset, Time_group, and Cell type.	SEMA3A CHD4 ACVR2A RBBP6	4.48e-05	200	44	4	7c261e39ac30b318511373ab7302aa53b8b81b9c
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	COL6A2 FRAS1 ITGB5 NOTCH3	4.48e-05	200	44	4	ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCell	COVID-19-Fibroblasts-Vascular_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	COL6A2 SEMA3G VWF NOTCH3	4.48e-05	200	44	4	c7f82196a0768ad96b1df8b8915bc541fb118a76
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2-Excitatory_Neuron.Slc17a7.Tac2.Syt15_(Medial_habenula)\|Thalamus / BrainAtlas - Mouse McCarroll V32	CCN6 WFIKKN2 RXFP2	6.07e-05	77	44	3	7f624e9262bd0dc2ac4176f43c91a4bc0f521fe5
ToppCell	TCGA-Ovary-Primary_Tumor\|TCGA-Ovary / Sample_Type by Project: Shred V9	TCTN3 CHD4 VWF	1.57e-04	106	44	3	14f548be39cec604fbdae0382cbf434fa4049840
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma\|TCGA-Ovary / Sample_Type by Project: Shred V9	TCTN3 CHD4 VWF	1.57e-04	106	44	3	939b80950d39cdc7149a05fdfb64c8810064cdb1
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma\|TCGA-Ovary / Sample_Type by Project: Shred V9	TCTN3 CHD4 VWF	1.57e-04	106	44	3	e9e1b55f32b3d5b9eeec94a997912e5c21c1fb48
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RXFP2 OTOG SEMA3B	1.66e-04	108	44	3	d620f07243c2628494e689bbfabc14c453f4b1f4
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)-\|Striatum / BrainAtlas - Mouse McCarroll V32	COL6A2 VEGFD NOTCH3	3.13e-04	134	44	3	a3547a68012d879d4dfe80394eace70808722e43
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)\|Striatum / BrainAtlas - Mouse McCarroll V32	COL6A2 VEGFD NOTCH3	3.13e-04	134	44	3	9458e2d0dbc18d9025b66b59f3ecc2fbc5384940
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SEMA3A MUC19 COL6A2	3.86e-04	144	44	3	1c001a5a3bbe4ecbce8305f8b260e933033550dd
ToppCell	E18.5-samps-Mesenchymal-Pericyte-pericyte_C\|E18.5-samps / Age Group, Lineage, Cell class and subclass	CRIM1 NOTCH3 DHRS7C	4.44e-04	151	44	3	3f2abaa42876ce7a71d934ff16abe0cab0991a05
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 NOTCH3 RXFP2	4.52e-04	152	44	3	d5ba87b5d34e52cef8475befafea962d70fa8a1d
ToppCell	droplet-Liver-LIVER_HEPATOCYTES\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 NOTCH3 RXFP2	4.52e-04	152	44	3	d88d68a788a3256671ebbc06e104833f1f58f07d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A2 ITGB5 NOTCH3	4.88e-04	156	44	3	6365b69ede98bc866e996bc52736b00401aacf6f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A DNMT3L RXFP2	4.88e-04	156	44	3	abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A DNMT3L RXFP2	4.88e-04	156	44	3	dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A2 ITGB5 NOTCH3	4.97e-04	157	44	3	bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D231\|Adult / Lineage, Cell type, age group and donor	COL6A2 CRIM1 NOTCH3	5.06e-04	158	44	3	8d64c0c9de910a3f4658778642d183c8b9b6f6a2
ToppCell	facs-Thymus-Epithelium-3m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF186 GPA33 WFIKKN2	5.45e-04	162	44	3	25323785dd33337bcefd05958a4a1a208a9ceb04
ToppCell	facs-Thymus-Epithelium-3m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF186 GPA33 WFIKKN2	5.45e-04	162	44	3	3dc39db0d5f6f3d7bcc312a6bce7aaeb914138d1
ToppCell	facs-Thymus-Epithelium-3m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF186 GPA33 WFIKKN2	5.45e-04	162	44	3	0a7138266054ea5954649c8b61ef93905d56b068
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MUC19 SEMA3G VWF	5.45e-04	162	44	3	25bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3G VWF CRIM1	5.85e-04	166	44	3	7a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCell	TCGA-Lung-Solid_Tissue_Normal\|TCGA-Lung / Sample_Type by Project: Shred V9	SEMA3G VEGFD GPA33	5.85e-04	166	44	3	a8ebdd3cb7f59b3feeaacda45ce6d40d10db556f
ToppCell	TCGA-Lung-Solid_Tissue_Normal-Lung\|TCGA-Lung / Sample_Type by Project: Shred V9	SEMA3G VEGFD GPA33	5.85e-04	166	44	3	c64971c27cb445dffc5a636d4b6a60261b93a2db
ToppCell	TCGA-Lung-Solid_Tissue_Normal-Lung-Lung_normal_tissue-6\|TCGA-Lung / Sample_Type by Project: Shred V9	SEMA3G VEGFD GPA33	5.85e-04	166	44	3	188f2575511f418216874aed9118aa6f165252cb
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3G VWF CRIM1	5.85e-04	166	44	3	bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCell	TCGA-Lung-Solid_Tissue_Normal-Lung-Lung_normal_tissue\|TCGA-Lung / Sample_Type by Project: Shred V9	SEMA3G VEGFD GPA33	5.85e-04	166	44	3	2f3072a7af048f184d33065fdd36153fd563155a
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A2 ITGB5 ZNF587B	5.95e-04	167	44	3	805129f887078340b260aa136b0ba19f2bd6ea03
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-NK_CD56bright\|ICU-NoSEP / Disease, Lineage and Cell Type	ZNF814 ERBB2 RBBP6	5.95e-04	167	44	3	f4f188a8efca8cdd0ecfb857fe4538c10847eadd
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A2 ITGB5 ZNF587B	5.95e-04	167	44	3	31cf8bf2eb523f6e7e319620648ff37fc09e2601
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A2 ITGB5 ZNF587B	5.95e-04	167	44	3	3acb18428d1d33ad430c2fd031b1a91baee3c01d
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	COL6A2 CRIM1 VEGFD	6.05e-04	168	44	3	3fe432267656aff81b6d92c18d1b6fc0cde73d6a
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A VWF CRIM1	6.05e-04	168	44	3	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A VWF CRIM1	6.05e-04	168	44	3	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL6A2 VWF VEGFD	6.26e-04	170	44	3	7fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EZH2 NOTCH3 RXFP2	6.37e-04	171	44	3	b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell	10x5'-GI_small-bowel-Lymphocytic_NK-NK_CD16\|GI_small-bowel / Manually curated celltypes from each tissue	COL6A2 ERBB2 SORL1	6.37e-04	171	44	3	1ee505b91f15191d294a5d491ecdf154c08b8622
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EZH2 NOTCH3 RXFP2	6.37e-04	171	44	3	b0373ed8283ee1792b6a490bff93906546978593
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell\|Adult / Lineage, Cell type, age group and donor	COL6A2 CRIM1 NOTCH3	6.48e-04	172	44	3	c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MUC19 SEMA3G VWF	6.48e-04	172	44	3	de9b11ab109d04937186c09772cec9105a935f95
ToppCell	facs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A VWF CRIM1	6.48e-04	172	44	3	f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	XPO5 PIP4P2 SEMA3B	6.48e-04	172	44	3	da959c1abadafd79b7a0088a25eb8ef8efa3a0c2
ToppCell	facs-Heart-LV-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A VWF CRIM1	6.48e-04	172	44	3	6ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCell	Endothelial-B-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	SEMA3A COL6A2 VEGFD	6.48e-04	172	44	3	8a527dff06d841a86c7eb04a1dd9630787294da4
ToppCell	facs-Trachea-nan-24m-Mesenchymal-chondrocyte\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PROSER2 CRIM1 CHD5	6.59e-04	173	44	3	2226505610af1becc253d0a5550627144ef0ed6b
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MUC19 SEMA3G VWF	6.59e-04	173	44	3	3a9e9a09b3eeb37cbe56d650e112a8398879477f
ToppCell	ASK428-Immune-B_cell\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	ZNF814 GTF2H2 XPO5	6.70e-04	174	44	3	b5a7a612a515736cf3489afd0f6ad2054d54526f
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DLG3 CHD5 NOTCH3	6.70e-04	174	44	3	a7ade7372e83edd4e3983e77f8417b51f0b47340
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3A RXFP2 SEMA3B	6.81e-04	175	44	3	442f261a3b2c4d2523f7d4089178f8c79cac2f0f
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3A RXFP2 SEMA3B	6.81e-04	175	44	3	35fb7735dd3355476fe60404833cb60bd066bcf1
ToppCell	P03-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SEMA3A FRAS1 SEMA3B	6.93e-04	176	44	3	f3a54038cde58326f1caed96ecca33c141bcc8b3
ToppCell	ASK452-Endothelial-Lymphatic\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	SEMA3A ACVR2A XPO5	6.93e-04	176	44	3	b4d280ecc07701d526f50d44c45ea91b3eeb00b1
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Mesenchymal-Mes\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL6A2 SEMA3G NOTCH3	6.93e-04	176	44	3	396061ce25574d7d688bbc66275ce94f27e96b05
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Mesenchymal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL6A2 SEMA3G NOTCH3	6.93e-04	176	44	3	5e38cc9779121cdab574a38a8f5a02d2c1b33b2b
ToppCell	Club_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	ERBB2 NOTCH3 SEMA3B	6.93e-04	176	44	3	88c4ed0ab4a4ede8cad21385d799b723b5786cd9
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MUC19 SEMA3G VWF	7.04e-04	177	44	3	5ff8dcfb030312126695d53a026d2e104a401b83
ToppCell	356C-Fibroblasts-Fibroblast-G-\|356C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 CRIM1 VEGFD	7.04e-04	177	44	3	7617270f49cd6b7ba66db72d20560cee985012b2
ToppCell	356C-Fibroblasts-Fibroblast-G\|356C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 CRIM1 VEGFD	7.04e-04	177	44	3	8220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A2 CRIM1 CHD5	7.16e-04	178	44	3	e5e5f5b4a27e120a1076b1cb250fa25d0c336956
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A2 CRIM1 CHD5	7.16e-04	178	44	3	c661246269ce26c4fc62e12f86c5f90a2dcfdce0
ToppCell	droplet-Fat-Scat-21m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 GPA33 DHRS7C	7.16e-04	178	44	3	5fc9f41609735b972a2cd0830182d13742cd5bf5
ToppCell	facs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PROSER2 VWF CRIM1	7.16e-04	178	44	3	ccd37575b60102f5e647c01546e8ff8fec638bd7
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MUC19 SEMA3G VWF	7.16e-04	178	44	3	c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCell	facs-Lung-18m-Endothelial-venous_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PROSER2 VWF CRIM1	7.16e-04	178	44	3	87b04753650e45f12299c8456fb980d6c0d5961c
ToppCell	facs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PROSER2 VWF CRIM1	7.16e-04	178	44	3	ebfae386a518ea33911ba3ff40464c94d18ef695
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	COL6A2 WFIKKN2 SEMA3B	7.16e-04	178	44	3	cda7695411655bd6d0ba69e5041ca7530a9dad3a
ToppCell	C_00\|World / shred on cell type and cluster	ZNHIT6 CSRNP2 SQSTM1	7.27e-04	179	44	3	da2dadc3266ffebd4a34ac61bfa05fddcadcde4c
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SEMA3G VWF CRIM1	7.27e-04	179	44	3	8c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell	COPD-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	ERBB2 VWF CRIM1	7.27e-04	179	44	3	e816dd846a6918ec143b57a380c3a47ed073b66e
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SEMA3G VWF CRIM1	7.27e-04	179	44	3	d2db9e70b780643f1e004c41a70464d0abe26088
ToppCell	390C-Fibroblasts-Fibroblast-G\|390C / Donor, Lineage, Cell class and subclass (all cells)	COL6A2 FRAS1 VEGFD	7.39e-04	180	44	3	137fc14859c89e1ecd98bee388bb58c04b835847
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CCN6 SEMA3G VWF	7.39e-04	180	44	3	67c5068b660cd5e727a665cefe3bd5f8ae887221
ToppCell	droplet-Limb_Muscle-Pre-Sort\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF CRIM1 NOTCH3	7.39e-04	180	44	3	af2bafcd1b2082629de3ea336711add01565c4c4
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VWF NOTCH3 DNMT3L	7.39e-04	180	44	3	455d1e3ccf2ab609954f3b870e8f514ddca735f4
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Mesenchymal-Mes-Pericyte\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL6A2 SEMA3G NOTCH3	7.39e-04	180	44	3	1e5a3f93df453f716cd78d29bb500653b2f5efb1
Computational	Placenta genes.	COL6A2 ERBB2 VWF CRIM1 ITGB5 GPA33 NOTCH3	8.47e-05	463	26	7	MODULE_38
Drug	angiogenesis inhibitor	SEMA3A COL6A2 VWF VEGFD SEMA3B	4.73e-06	128	44	5	CID002812173
Disease	Endometrial Neoplasms	CHD4 EZH2 SEMA3B	7.29e-05	58	41	3	C0014170
Disease	Endometrial Carcinoma	CHD4 EZH2 SEMA3B	1.39e-04	72	41	3	C0476089
Disease	Impaired cognition	NOTCH3 SORL1	1.70e-04	14	41	2	C0338656
Disease	Replication Error Phenotype	ACVR2A XPO5	1.96e-04	15	41	2	C1721098
Disease	Microsatellite Instability	ACVR2A XPO5	1.96e-04	15	41	2	C0920269
Disease	heart rate	PROSER2 RBBP6 LIPI SORL1	2.67e-04	225	41	4	EFO_0004326
Disease	prion disease	SEMA3A RCHY1	3.17e-04	19	41	2	EFO_0004720
Disease	urinary bladder cancer (is_marker_for)	ERBB2 EZH2 VEGFD	4.47e-04	107	41	3	DOID:11054 (is_marker_for)
Disease	cancer (implicated_via_orthology)	DLG3 RBBP6 ITGB5 NOTCH3	5.17e-04	268	41	4	DOID:162 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	SEMA3A ERBB2 VWF EZH2 CHD5 NOTCH3 SORL1	6.32e-04	1074	41	7	C0006142
Disease	colorectal cancer (is_implicated_in)	CHD4 EZH2 XPO5	6.40e-04	121	41	3	DOID:9256 (is_implicated_in)
Disease	intestinal cancer (implicated_via_orthology)	ERBB2 NOTCH3	9.10e-04	32	41	2	DOID:10155 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
CEKCSKPCARVCYGL	ERBB2	331	P04626
VCKDGGELLCCDACP	CHD5	421	Q8TDI0
PDCTRCYCFECVDSL	DNMT3L	111	Q9UJW3
EECGCDCRLYCDPEA	CSRNP2	211	Q9H175
CVEKKDSPEVYFCCC	ACVR2A	91	P27037
YFCAECDVPLCVVPC	PGBD4	561	Q96DM1
GKCCPECISRNGYCV	FRAS1	336	Q86XX4
IIGIIIYCCCCRGKD	GPA33	251	Q99795
CPCYLAVRECDPDLC	EZH2	571	Q15910
DTCCEIGYCEPRTCL	MUC19	8216	Q7Z5P9
KCVDQPDGYECRCAE	NOTCH3	521	Q9UM47
LCECSPGYLGTRCEC	ITGB5	486	P18084
VIPCCGNSYCDECIR	RBBP6	271	Q7Z6E9
YKPTFCGICLDKRCC	CCN6	291	O95389
TYVRETCGCCDCEKR	COL6A2	596	P12110
ETCGTEEAKYRCPRC	ZNHIT6	221	Q9NWK9
CCDLYECKPVFGVDC	CRIM1	241	Q9NZV1
HCCKCPECYEVTRLA	DLG3	6	Q92796
CCKPVCYVPTCSEDS	KRTAP10-1	146	P60331
CVPDVAKEVLDCYGC	DHRS7C	106	A6NNS2
FCRVCKDGGELLCCD	CHD4	451	Q14839
RCCPYKSCECDCDTI	OTOG	2636	Q6ZRI0
CDLECLVCREPYSCP	RNF186	36	Q9NXI6
CPQCRAKYCELPVEC	GTF2H2C;	291	Q6P1K8
CIPLSYKCDLEDDCG	SORL1	1131	Q92673
CVDCDCFKEKSCPRL	LIPI	286	Q6XZB0
FEEPVLCDGGVCCLC	PROSER2	76	Q86WR7
YVRCPCNCLLICKDT	PIP4P2	96	Q8N4L2
YPQCCDCKETELECV	RXFP2	111	Q8WXD0
GKACAECCLARDPYC	SEMA3A	521	Q14563
KCSVCPDYDLCSVCE	SQSTM1	141	Q13501
ADQCCPEYECVCDPV	VWF	2316	P04275
CPQCRAKYCELPVEC	GTF2H2	291	Q13888
RVCTECCLARDPYCA	SEMA3B	521	Q13214
FCEEFKEKCPICVPC	XPO5	36	Q9HAV4
LPREECYVCCECGKS	ZNF587B	236	E7ETH6
GTACAECCLARDPYC	SEMA3G	526	Q9NS98
GCLLKAPCCDKLYTC	RCHY1	26	Q96PM5
EDRCECVCKTPCPKD	VEGFD	266	O43915
PGACDINCCCDRDCY	TCTN3	96	Q6NUS6
CDGKCVICDSYVRPC	PHF5A	26	Q7RTV0
EQCCPICCSEYIKDD	PJA2	631	O43164
LTREECYVCCECGKS	ZNF814	236	B7Z6K7
PYECRECGKAFCCSS	ZNF181	376	Q2M3W8
CETDQECETYEKCCP	WFIKKN2	66	Q8TEU8
ECETYEKCCPNVCGT	WFIKKN2	71	Q8TEU8