Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesscellular response to virus

IFNK TLR3 TLR7 WDFY4 IFNL2

1.28e-0590695GO:0098586
DomainLRR

LRRC8E TRIL SLIT2 CIITA TLR3 LRRK2 TLR7 LRRC30 LRRC47

5.25e-08201699PS51450
DomainLRR_1

LRRC8E TRIL SLIT2 CIITA TLR3 LRRK2 TLR7 LRRC30 LRRC47

1.09e-07219699PF00560
DomainLRR_8

LRRC8E TRIL SLIT2 TLR3 LRRK2 TLR7 LRRC30 LRRC47

2.18e-07171698PF13855
DomainLeu-rich_rpt_typical-subtyp

LRRC8E TRIL SLIT2 TLR3 LRRK2 TLR7 LRRC30 LRRC47

2.84e-07177698IPR003591
DomainLRR_TYP

LRRC8E TRIL SLIT2 TLR3 LRRK2 TLR7 LRRC30 LRRC47

2.84e-07177698SM00369
DomainLeu-rich_rpt

LRRC8E TRIL SLIT2 CIITA TLR3 LRRK2 TLR7 LRRC30 LRRC47

6.61e-07271699IPR001611
Domain-

LRRC8E TRIL SLIT2 CIITA TLR3 LRRK2 TLR7 LRRC30 LRRC47

2.68e-063216993.80.10.10
DomainL_dom-like

LRRC8E TRIL SLIT2 CIITA TLR3 LRRK2 TLR7 LRRC30 LRRC47

3.20e-06328699IPR032675
DomainLRRCT

TRIL SLIT2 TLR3 TLR7

5.67e-0632694PF01463
DomainCys-rich_flank_reg_C

TRIL SLIT2 TLR3 TLR7

3.43e-0490694IPR000483
DomainLRRCT

TRIL SLIT2 TLR3 TLR7

3.43e-0490694SM00082
DomainLRRNT

TRIL SLIT2 TLR3 TLR7

4.74e-0498694IPR000372
DomainLRRNT

TRIL SLIT2 TLR3 TLR7

4.74e-0498694SM00013
DomainTransglut_N

TGM3 TGM6

4.76e-049692PF00868
DomainTRANSGLUTAMINASES

TGM3 TGM6

4.76e-049692PS00547
DomainTransglutaminase_N

TGM3 TGM6

4.76e-049692IPR001102
DomainTransglut_C

TGM3 TGM6

4.76e-049692PF00927
Domain-

TGM3 TGM6

4.76e-0496923.90.260.10
DomainGln_gamma-glutamylTfrase_euk

TGM3 TGM6

4.76e-049692IPR023608
DomainTransglutaminase_AS

TGM3 TGM6

4.76e-049692IPR013808
DomainARM-like

ARID2 MROH2B LRRK2 CUL9 HEATR5B WDFY4

4.83e-04270696IPR011989
DomainTransglutaminase_C

TGM3 TGM6

5.94e-0410692IPR008958
DomainTGc

TGM3 TGM6

7.24e-0411692SM00460
DomainTransglut_core

TGM3 TGM6

7.24e-0411692PF01841
DomainTransglutaminase-like

TGM3 TGM6

7.24e-0411692IPR002931
Domain-

MROH2B LRRK2 CUL9 HEATR5B WDFY4

1.37e-032226951.25.10.10
DomainARM-type_fold

ARID2 MROH2B LRRK2 CUL9 HEATR5B WDFY4

1.57e-03339696IPR016024
DomainTIR

TLR3 TLR7

2.70e-0321692SM00255
DomainTIR

TLR3 TLR7

2.96e-0322692PF01582
Domain-

TLR3 TLR7

3.24e-03236923.40.50.10140
DomainTIR

TLR3 TLR7

3.52e-0324692PS50104
DomainTIR_dom

TLR3 TLR7

3.82e-0325692IPR000157
Pubmed

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.

BST1 LRRK2 STK39 SPPL2B

5.89e-073370425064009
Pubmed

Toll-like receptors 3 and 7 agonists enhance tumor cell lysis by human gammadelta T cells.

TLR3 TLR7

3.99e-06270219887600
Pubmed

Plasmacytoid dendritic cells regulate colitis-associated tumorigenesis by controlling myeloid-derived suppressor cell infiltration.

TLR3 TLR7

3.99e-06270232810576
Pubmed

Type I IFN-mediated synergistic activation of mouse and human DC subsets by TLR agonists.

TLR3 TLR7

3.99e-06270226255864
Pubmed

Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL).

TRIL TLR3

3.99e-06270221911501
Pubmed

TLR3\TLR7 as Differentially Expressed Markers Among Viral, Nonviral, and Autoimmune Diseases in Egyptian Patients.

TLR3 TLR7

3.99e-06270234342515
Pubmed

U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.

TLR3 TLR7

3.99e-06270216368889
Pubmed

Extracellular RNA Sensing Mediates Inflammation and Organ Injury in a Murine Model of Polytrauma.

TLR3 TLR7

3.99e-06270237133342
Pubmed

Upregulation of TLR7 and TLR3 gene expression in the lung of respiratory syncytial virus infected mice.

TLR3 TLR7

3.99e-06270219445181
Pubmed

Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages.

TLR3 TLR7

3.99e-06270234161582
Pubmed

RNA receptors, TLR3 and TLR7, are potentially associated with SLE clinical features.

TLR3 TLR7

3.99e-06270233650302
Pubmed

Expression of Toll-like receptor 3 and Toll-like receptor 7 in muscle is characteristic of inflammatory myopathy and is differentially regulated by Th1 and Th17 cytokines.

TLR3 TLR7

3.99e-06270220309865
Pubmed

Activation of autoreactive B cells by endogenous TLR7 and TLR3 RNA ligands.

TLR3 TLR7

3.99e-06270223019335
Pubmed

Prognostic impact of toll-like receptors gene polymorphism on outcome of COVID-19 pneumonia: A case-control study.

TLR3 TLR7

3.99e-06270235063671
Pubmed

Dysregulation of Toll-Like Receptor 7 Compromises Innate and Adaptive T Cell Responses and Host Resistance to an Attenuated West Nile Virus Infection in Old Mice.

TLR3 TLR7

3.99e-06270226581984
Pubmed

Differential effects of toll-like receptor stimulation on mRNA-driven myogenic conversion of human and mouse fibroblasts.

TLR3 TLR7

3.99e-06270227586271
Pubmed

Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity.

FBXL18 LRRK2

3.99e-06270227890708
Pubmed

Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway.

TLR3 TLR7

3.99e-06270227046485
Pubmed

TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements.

TLR3 TLR7

3.99e-06270216105838
Pubmed

MACC1 decreases the chemosensitivity of gastric cancer cells to oxaliplatin by regulating FASN expression.

MACC1 FASN

3.99e-06270228339092
Pubmed

Toll-Like Receptor 7 Enhances Rabies Virus-Induced Humoral Immunity by Facilitating the Formation of Germinal Centers.

TLR3 TLR7

3.99e-06270230906301
Pubmed

Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo.

TLR3 TLR7

3.99e-06270216537810
Pubmed

Association of TLR3 gene 1377C/T (rs3775290) and TLR7 gene C/G (rs3853839) polymorphism with hand, foot, and mouth disease caused by human enterovirus 71 infection susceptibility and severity in the Chinese Han population: A meta-analysis of case-control studies.

TLR3 TLR7

3.99e-06270235801751
Pubmed

Friend retrovirus drives cytotoxic effectors through Toll-like receptor 3.

TLR3 TLR7

3.99e-06270225539593
Pubmed

Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production.

TLR3 TLR7

3.99e-06270227084119
Pubmed

Gluten T cell epitope targeting by TG3 and TG6; implications for dermatitis herpetiformis and gluten ataxia.

TGM3 TGM6

3.99e-06270220300788
Pubmed

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.

BST1 LRRK2 STK39

4.29e-061670321292315
Pubmed

Toll-like receptor 3 and 7/8 function is impaired in hepatitis C rapid fibrosis progression post-liver transplantation.

TLR3 TLR7

1.20e-05370223425350
Pubmed

Immunoadjuvant effects of polyadenylic:polyuridylic acids through TLR3 and TLR7.

TLR3 TLR7

1.20e-05370217981792
Pubmed

Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population.

TLR3 TLR7

1.20e-05370224445780
Pubmed

Expression of toll-like receptors 3, 7, and 9 in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.

TLR3 TLR7

1.20e-05370224692849
Pubmed

Toll-like receptor polymorphisms and age-related macular degeneration.

TLR3 TLR7

1.20e-05370218385087
Pubmed

Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth.

TLR3 TLR7

1.20e-05370228300057
Pubmed

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.

TLR3 TLR7

1.20e-05370222565312
Pubmed

Cryo-EM structures of Toll-like receptors in complex with UNC93B1.

TLR3 TLR7

1.20e-05370233432245
Pubmed

Association between Toll-Like Receptor 3 (TLR3) rs3775290, TLR7 rs179008, TLR9 rs352140 and Chronic HCV.

TLR3 TLR7

1.20e-05370230321082
Pubmed

Modulation of TLR 3, 7 and 8 expressions in HCV genotype 3 infected individuals: potential correlations of pathogenesis and spontaneous clearance.

TLR3 TLR7

1.20e-05370225126563
Pubmed

TLR3-, TLR7-, and TLR9-mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells.

TLR3 TLR7

1.20e-05370215210814
Pubmed

Expression of IL-27 p28 by Theiler's virus-infected macrophages depends on TLR3 and TLR7 activation of JNK-MAP-kinases.

TLR3 TLR7

1.20e-05370217675254
Pubmed

Genetically defined variants of toll-like receptors 3, 7 and 9 as phenotype and risk modifier factors for psoriasis.

TLR3 TLR7

1.20e-05370229290528
Pubmed

Synergy of TRIF-dependent TLR3 and MyD88-dependent TLR7 in up-regulating expression of mouse FPR2, a promiscuous G-protein-coupled receptor, in microglial cells.

TLR3 TLR7

1.20e-05370219559490
Pubmed

Vitamin D3 Alters the Expression of Toll-like Receptors in Peripheral Blood Mononuclear Cells of Patients With Systemic Lupus Erythematosus.

TLR3 TLR7

1.20e-05370228544067
Pubmed

Hepatitis C virus infection decreases the expression of Toll-like receptors 3 and 7 via upregulation of miR-758.

TLR3 TLR7

1.20e-05370225008898
Pubmed

High-resolution arrays reveal burden of copy number variations on Parkinson disease genes associated with increased disease risk in random cohorts.

LRRK2 ATP13A2

1.20e-05370227399248
Pubmed

Dendritic cells and NK cells stimulate bystander T cell activation in response to TLR agonists through secretion of IFN-alpha beta and IFN-gamma.

TLR3 TLR7

1.20e-05370215634897
Pubmed

Respiratory macrophages and dendritic cells mediate respiratory syncytial virus-induced IL-33 production in TLR3- or TLR7-dependent manner.

TLR3 TLR7

1.20e-05370226603638
Pubmed

Cervical cancer cell supernatants induce a phenotypic switch from U937-derived macrophage-activated M1 state into M2-like suppressor phenotype with change in Toll-like receptor profile.

TLR3 TLR7

1.20e-05370225309919
Pubmed

The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection.

TLR3 TLR7

1.20e-05370229947302
Pubmed

Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis.

SLIT2 TLR3

1.20e-05370232999457
Pubmed

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.

TLR3 TLR7

1.20e-05370216111635
Pubmed

B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection.

TLR3 TLR7

1.20e-05370223761632
Pubmed

In vivo liver expression of TLR2, TLR3 and TLR7 in chronic hepatitis C.

TLR3 TLR7

1.20e-05370223489702
Pubmed

Toll-like receptors 3, 7, and 9 in Juvenile nasopharyngeal angiofibroma.

TLR3 TLR7

1.20e-05370225912131
Pubmed

Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.

TLR3 TLR7

1.20e-05370216935934
Pubmed

Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection.

TLR3 TLR7

1.20e-05370218021446
Pubmed

Contribution of Toll like receptor polymorphisms to dengue susceptibility and clinical outcome among eastern Indian patients.

TLR3 TLR7

1.20e-05370231481269
Pubmed

Innate immune memory and homeostasis may be conferred through crosstalk between the TLR3 and TLR7 pathways.

TLR3 TLR7

1.20e-05370227405980
Pubmed

Down-regulation of LRRK2 in control and DAT transfected HEK cells increases manganese-induced oxidative stress and cell toxicity.

LRRK2 ATP13A2

1.20e-05370223628791
Pubmed

Characterization of TLR-induced inflammatory responses in COPD and control lung tissue explants.

TLR3 TLR7

1.20e-05370227729782
Pubmed

MAVS mediates a protective immune response in the brain to Rift Valley fever virus.

TLR3 TLR7

1.20e-05370235584192
Pubmed

Lack of association between three single nucleotide polymorphisms in the PARK9, PARK15, and BST1 genes and Parkinson's disease in the northern Han Chinese population.

BST1 ATP13A2

1.20e-05370222490479
Pubmed

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.

TLR3 TLR7

1.20e-05370229768176
Pubmed

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.

TLR3 TLR7

1.20e-05370237020259
Pubmed

Transcriptomic Analysis and C-Terminal Epitope Tagging Reveal Differential Processing and Signaling of Endogenous TLR3 and TLR7.

TLR3 TLR7

1.20e-05370234211474
Pubmed

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling.

TLR3 TLR7

2.39e-05470217452530
Pubmed

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.

TLR3 TLR7

2.39e-05470219451267
Pubmed

Structural imaging in the presymptomatic stage of genetically determined parkinsonism.

LRRK2 ATP13A2

2.39e-05470220483373
Pubmed

TLR7/9 versus TLR3/MDA5 signaling during virus infections and diabetes.

TLR3 TLR7

2.39e-05470221844166
Pubmed

Painful pathways induced by TLR stimulation of dorsal root ganglion neurons.

TLR3 TLR7

2.39e-05470221515789
Pubmed

Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.

TLR3 TLR7

2.39e-05470216985170
Pubmed

Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design.

TLR3 TLR7

2.39e-05470228416600
Pubmed

Expression of TLR3, 4, 7 and 9 in cutaneous malignant melanoma: relationship with clinicopathological characteristics and prognosis.

TLR3 TLR7

2.39e-05470223179584
Pubmed

Extracellular MicroRNAs Induce Potent Innate Immune Responses via TLR7/MyD88-Dependent Mechanisms.

TLR3 TLR7

2.39e-05470228768728
Pubmed

Endosomal TLR3, TLR7, and TLR8 control neuronal morphology through different transcriptional programs.

TLR3 TLR7

2.39e-05470229777026
Pubmed

The Src-ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage.

TLR3 TLR7

2.39e-05470237158982
Pubmed

Overexpression of TLR3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma.

TLR3 TLR7

2.39e-05470221990957
Pubmed

Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico.

TLR3 TLR7

2.39e-05470233138336
Pubmed

Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via Toll-like receptor 7 signaling.

TLR3 TLR7

2.39e-05470226363072
Pubmed

Double-stranded RNA induces shedding of the 34-kDa soluble TNFR1 from human airway epithelial cells via TLR3-TRIF-RIP1-dependent signaling: roles for dual oxidase 2- and caspase-dependent pathways.

TLR3 DUOX2

2.39e-05470221148036
Pubmed

Recognition of pathogen-associated nucleic acids by endosomal nucleic acid-sensing toll-like receptors.

TLR3 TLR7

2.39e-05470223369718
Pubmed

Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus.

BST1 LRRK2

2.39e-05470220697102
Pubmed

The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells.

TLR3 TLR7

2.39e-05470221538349
Pubmed

Regulation of Toll-like receptor-induced chemokine production in murine dendritic cells by mitogen-activated protein kinases.

TLR3 TLR7

2.39e-05470220451253
Pubmed

Toll-like receptors 3, 7, 8, and 9 in gastric cancer.

TLR3 TLR7

2.39e-05470236271773
Pubmed

A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity.

TLR3 TLR7

3.98e-05570221525388
Pubmed

UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major.

TLR3 TLR7

3.98e-05570223325805
Pubmed

TLR3 and TLR7 are involved in expression of IL-23 subunits while TLR3 but not TLR7 is involved in expression of IFN-beta by Theiler's virus-infected RAW264.7 cells.

TLR3 TLR7

3.98e-05570217897860
Pubmed

Expression of soluble Toll-like receptors in pleural effusions.

TLR3 TLR7

3.98e-05570220819670
Pubmed

Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.

TLR3 TLR7

3.98e-05570223290966
Pubmed

Upregulation of Toll-like receptor (TLR) expression and release of cytokines from P815 mast cells by GM-CSF.

TLR3 TLR7

3.98e-05570219426550
Pubmed

IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells.

TLR7 IFNL2

3.98e-05570222636319
Pubmed

Macrophages recognize streptococci through bacterial single-stranded RNA.

TLR3 TLR7

3.98e-05570221164516
Pubmed

TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification.

TLR3 TLR7

3.98e-05570222821982
Pubmed

Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.

TLR3 TLR7

3.98e-05570216286015
Pubmed

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9.

TLR3 TLR7

3.98e-05570219740627
Pubmed

Distinct dictation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signal pathways.

TLR3 TLR7

3.98e-05570225188232
Pubmed

Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.

TLR3 TLR7

3.98e-05570225756897
Pubmed

TLR agonists downregulate H2-O in CD8alpha- dendritic cells.

TLR3 TLR7

3.98e-05570221918198
Pubmed

Variable requirement of dendritic cells for recruitment of NK and T cells to different TLR agonists.

TLR3 TLR7

3.98e-05570217339488
Pubmed

Low expression of Toll-like receptors in peripheral blood mononuclear cells of pediatric patients with acute lymphoblastic leukemia.

TLR3 TLR7

3.98e-05570227277333
GeneFamilyTransglutaminases

TGM3 TGM6

2.25e-049462773
GeneFamilyCD molecules|Toll like receptors

TLR3 TLR7

2.81e-0410462948
GeneFamilyParkinson disease associated genes

LRRK2 ATP13A2

7.43e-0416462672
GeneFamilyInterferons

IFNK IFNL2

2.99e-0332462598
CoexpressionAtlasMyeloid Cells, DC.8+.Sp, CD11b CD45 CD4 CD11c CD8a, Spleen, avg-1

CIITA TLR3 LRRK2 WDFY4

9.71e-0577664GSM605827_100
CoexpressionAtlasMyeloid Cells, DC.8+.Sp, CD11b CD11c CD45 CD8a CD4, Spleen, avg-2

CIITA TLR3 LRRK2 WDFY4

1.18e-0481664GSM538260_100
CoexpressionAtlasMyeloid Cells, DC.103+11b-.Lv, CD45+ CD11c+ MHC-II+ CD11b low CD103+, Liver, avg-2

CIITA TLR3 LRRK2 WDFY4

1.18e-0481664GSM538234_100
CoexpressionAtlasMyeloid Cells, DC.103+11b-.Lu, CD11chi CD11b low CD103+ MHCII+ SiglecF-, Lung, avg-3

CIITA TLR3 LRRK2 WDFY4

1.24e-0482664GSM538231_100
CoexpressionAtlasMyeloid Cells, DC.8+.Sp, CD11b CD4 CD45 CD11c CD8a, Spleen, avg-2

CIITA TLR3 LRRK2 WDFY4

1.43e-0485664GSM538258_100
CoexpressionAtlasMyeloid Cells, DC.8+.MLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-3

CIITA TLR3 LRRK2 WDFY4

1.56e-0487664GSM538252_100
CoexpressionAtlasMyeloid Cells, DC.8-.Th, CD11b-FITC CD4-PE MHCII-APC CD11c-eFluor780 CD8-eF, Thymus, avg-3

CIITA TLR3 LRRK2 WDFY4

1.56e-0487664GSM605831_100
CoexpressionAtlasMyeloid Cells, DC.8+.SLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-3

CIITA TLR3 LRRK2 WDFY4

1.56e-0487664GSM538255_100
CoexpressionAtlasMyeloid Cells, DC.8+.Th, CD11b-FITC CD4-PE MHCII-APC CD11c-eFluor780 CD8-eF, Thymus, avg-3

CIITA TLR3 LRRK2 WDFY4

1.56e-0487664GSM605828_100
CoexpressionAtlasMyeloid Cells, DC.103+11b-.Lu, MHCII+ CD11c+ CD103+ CD11b, Lung, avg-2

CIITA BST1 TLR3 LRRK2 ALPK1 SKIL WDFY4

2.46e-04402667GSM854241_500
CoexpressionAtlasMyeloid Cells, DC.103+11b-.Lv, CD45+ CD11c+ MHC-II+ CD11b low CD103+, Liver, avg-2

CIITA BST1 TLR3 LRRK2 DEPDC1 ALPK1 WDFY4

2.74e-04409667GSM538234_500
CoexpressionAtlasMyeloid Cells, DC.8+.Th, CD11b-FITC CD4-PE MHCII-APC CD11c-eFluor780 CD8-eF, Thymus, avg-3

CIITA BST1 TLR3 LRRK2 DEPDC1 ALPK1 WDFY4

2.86e-04412667GSM605828_500
CoexpressionAtlasMyeloid Cells, DC.8-.Th, CD11b-FITC CD4-PE MHCII-APC CD11c-eFluor780 CD8-eF, Thymus, avg-3

CIITA BST1 TLR3 LRRK2 DEPDC1 ALPK1 WDFY4

2.90e-04413667GSM605831_500
CoexpressionAtlasMyeloid Cells, DC.103+11b-.Lu, CD11chi CD11b low CD103+ MHCII+ SiglecF-, Lung, avg-3

CIITA BST1 TLR3 LRRK2 PCOLCE2 ALPK1 WDFY4

3.40e-04424667GSM538231_500
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE SLIT2 LRRK2 VAV3 ACVR1C CRHR2

5.49e-071907061bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE SLIT2 LRRK2 VAV3 ACVR1C CRHR2

5.84e-0719270625460ca9ebd3d49f666394cf99ab77a5e8f77250
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Alcam_(Alcam)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC22A6 PHYKPL P2RX6 ALPK1 KIF7

2.99e-061427056a656d28c9f5dfb03a3a2d908cf2edbe0a5b1206
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC22A6 PHYKPL P2RX6 ALPK1 KIF7

2.99e-06142705671ba8869db7a6dc69fd1caf0e561f15a312b170
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC22A6 PHYKPL P2RX6 ALPK1 KIF7

2.99e-061427053557084150670fd2e2634fc674f228ab85181b59
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Alcam_(Alcam)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC22A6 PHYKPL P2RX6 ALPK1 KIF7

2.99e-06142705a3d1f4b570b75402171e38c5a7c88e2896520c8f
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MACC1 HKDC1 TGM6 ACVR1C GPR88

3.67e-06148705223d6a640f3c34e73646a615593b9c0b4a4cbd6f
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-Klrb1a/b/c(-)_NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 STK39 TGM6 LRRC30 IFNL2

4.31e-06153705cb144b8c487286384b47fdff88ff98fcf0508899
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLIT2 TGM3 MACC1 HKDC1 GPR88

4.89e-061577055aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA EMB LRRK2 VAV3 DEPDC1

5.05e-0615870591d265e95156f16459924d3e4dd11c180e164eee
ToppCelldroplet-Liver-Npc-18m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA EMB TLR3 LRRK2 WDFY4

6.80e-06168705ce5e92a1df3acfa5cd8d5a134e4af231dc592a13
ToppCelldroplet-Liver-Npc-18m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA EMB TLR3 LRRK2 WDFY4

6.80e-0616870522c89d4eb44573f6301069ec7ca7cbd0dd958403
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MACC1 CIITA TLR3 LRRK2 WDFY4

7.84e-0617370570c0c13febd28b395fb3171ec8d7fbbc6c9d4eb7
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MACC1 OR51Q1 PCOLCE2 CRHR2 EGFEM1P

8.07e-06174705e0de0a14319be1a115e5be05d6f9b562e7b32c4a
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC22A6 MACC1 ARHGEF28 HKDC1 PAPPA

9.51e-06180705358923e4228035a3e90e2957392089219e90dcd7
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE SLIT2 LRRK2 VAV3 CRHR2

1.06e-05184705658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

TRHDE SLC22A6 ARHGEF28 HKDC1 PAPPA

1.14e-05187705d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCellChildren_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRHDE ARHGEF28 PCOLCE2 HEATR5B WDFY4

1.17e-05188705d7a9fb5b021e127b8d927658a55a71098d513b5c
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLIT2 EMB HKDC1 PAPPA STK39

1.17e-05188705ab6fa1beff91584d9303c2a33735de89aae8d5cd
ToppCellControl-Myeloid-Macrophage_Alveolar|Control / Disease state, Lineage and Cell class

TRHDE MACC1 ARHGEF28 PCOLCE2 HEATR5B

1.20e-05189705937e876122bc4b94372a4104e9c1a9068c232018
ToppCellIPF-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

TRHDE MACC1 ARHGEF28 PCOLCE2 HEATR5B

1.23e-051907052592765016f291565697265800a232b2edef3792
ToppCellCOPD-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

TRHDE MACC1 ARHGEF28 PCOLCE2 HEATR5B

1.23e-051907059fc763d65470ba8858b973689c4d4358faab7dd3
ToppCellControl-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

TRHDE MACC1 ARHGEF28 PCOLCE2 HEATR5B

1.27e-05191705a7bb8aba9c59c037d995a77928cc7b4d5cbb82b9
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MACC1 ARHGEF28 SYNE1 LRRK2

1.36e-05194705e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MACC1 ARHGEF28 LRRK2 VAV3

1.43e-051967056ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

TRHDE SLIT2 SYNE1 PAPPA ALPK1

1.47e-05197705fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

EMB BST1 SYNE1 LRRK2 ALPK1

1.54e-05199705b7af2b4fe6866cc8c78cf0f78390aab1b1b389ba
ToppCellCOVID-19-COVID-19_Severe-Myeloid-immature_Neutrophil|COVID-19_Severe / Disease, condition lineage and cell class

EMB BST1 SYNE1 PCOLCE2 ALPK1

1.58e-05200705cbe667eda1af222467df8bfa157aa22df488f133
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

EMB BST1 SYNE1 LRRK2 ALPK1

1.58e-05200705808571d74bb5c4d765ff13fc9393f88020d4e90d
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRHDE MACC1 CIITA PCOLCE2 WDFY4

1.58e-05200705ed785a6d08ca2b350dc3307b587eadfb2886d1f9
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

TGM3 HKDC1 ACVR1C GPR88

3.85e-05120704a6d0406a174d46ce06b41280292931954af88a59
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Gad2-Inhibitory_Neuron.Gad1Gad2.Gad2-Kcnc3_(GABAergic,_K/Na_Channel_State)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

MACC1 BPIFC TGM6

7.99e-0553703a58b0b1c9991cfebf20e206a129b79f494785138
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Gad2-Inhibitory_Neuron.Gad1Gad2.Gad2-Kcnc3_(GABAergic,_K/Na_Channel_State)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

MACC1 BPIFC TGM6

7.99e-0553703e90685a7c6ef223783b1c1a6b1896fd566449422
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Gad2|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

MACC1 BPIFC TGM6

7.99e-05537035ad1a5c5c9a1dc66dd7e6de6edbee0176678966c
ToppCellLPS_only-Myeloid-Dendritic_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCOLCE2 TLR7 ATP13A2 WDFY4

8.71e-05148704cb9365663f9cba35d47b5dd9079f42e88b70d915
ToppCellfacs-Pancreas-Exocrine-3m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VAV3 TLR7 ALPK1 WDFY4

8.71e-05148704bbf4933582b50b3412c805de5ed137107c996236
ToppCellfacs-Pancreas-Exocrine-3m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VAV3 TLR7 ALPK1 WDFY4

8.71e-051487046543860e3207a7de92a35bb6004be51287582f7a
ToppCellfacs-Pancreas-Exocrine-3m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VAV3 TLR7 ALPK1 WDFY4

8.71e-0514870479e376503a3f9504a1ec5af4a60a09cc80e19059
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EMB LRRK2 ALPK1 WDFY4

8.94e-0514970448fca6ae33d7722c024b43ce04f4dbce7b6b424b
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TRIL SLIT2 DEPDC1 RNF26

9.41e-0515170432d35906f4b2bd46b173e87f2dec972eb5da87b3
ToppCellfacs-Marrow-T-cells-24m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC22A6 SYNE1 TGM6 SLC27A4

9.41e-05151704ced4f7ee377a23a804ae6fde624e8b55b79f1fd8
ToppCellfacs-Marrow-T-cells-24m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC22A6 SYNE1 TGM6 SLC27A4

9.41e-05151704b52bb3b88e9a6473f571053537b8beb418678539
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EMB LRRK2 ALPK1 WDFY4

9.65e-051527047e686721b95c837f2b0d5116927c8ecacef055ee
ToppCellCOVID-19-Heart-Adipocyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

FASN PCOLCE2 ACVR1C ELL3

9.90e-0515370493958bd9c951222ba5b740d1cb83fd5d78a10e1e
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACC1 EMB HKDC1 ALPK1

1.02e-041547041e32969bee810adaf2d560f0824a16227df513d8
ToppCellFetal_29-31_weeks-Immune-dendritic_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CIITA TLR3 VAV3 WDFY4

1.04e-041557049f937ae48767fdcf1a944af4de0530d9c0ab441d
ToppCellfacs-Brain_Myeloid-Cortex_-18m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGM3 CIITA EMB VAV3

1.07e-041567042ba838bc864c2c1767bcab7bb4d790af96b91387
ToppCellfacs-Brain_Myeloid-Striatum_-18m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EMB BST1 SYNE1 LRRK2

1.09e-041577049d4308312301cb922f156a7b6aededc9e1c62807
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA EMB LRRK2 WDFY4

1.12e-0415870490ca742739a208d457db087655ba3d1c18a9da57
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA EMB LRRK2 VAV3

1.15e-04159704323cb4a2416d2e6bff0a3f225d2edeae9ab7dc76
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBXL18 EMB GRIN2D KIF7

1.18e-04160704830e3ef8c9708d25872c3052a0b2682fa9372111
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA EMB LRRK2 WDFY4

1.18e-041607048dae9b0cf90a09acb196223f45a14680102630b2
ToppCell367C-Epithelial_cells-Epithelial-D_(AT2)|367C / Donor, Lineage, Cell class and subclass (all cells)

FASN LRRK2 HKDC1 ACVR1C

1.18e-04160704ac5d573c135d66d6adddd42dfddd9d3e01532172
ToppCell367C-Epithelial_cells-Epithelial-D_(AT2)-|367C / Donor, Lineage, Cell class and subclass (all cells)

FASN LRRK2 HKDC1 ACVR1C

1.18e-04160704b81d218c20fe37921cf3c6c7db2da3bfd367230a
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

EMB BST1 SYNE1 LRRK2

1.18e-04160704bb1bb3673059768c0ea0160d29fff127f3a4ecb4
ToppCellLPS-IL1RA-Myeloid-Dendritic_cells-pDC|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TLR7 ATP13A2 WDFY4 ELL3

1.18e-04160704dee756a2dc9725520d439e7273c489c2284015d8
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

EMB BST1 SYNE1 LRRK2

1.18e-0416070476f49b8b4450fa8acd36326bfa36a5d1f4bd95fb
ToppCellfacs-Brain_Myeloid-Cerebellum-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA EMB LRRK2 VAV3

1.18e-041607041f7acdc8b08152d5817fc53bbf47b4a22d9c91b5
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA EMB LRRK2 DEPDC1

1.23e-0416270493bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|356C / Donor, Lineage, Cell class and subclass (all cells)

SMG8 PCOLCE2 WDFY4 SLC27A4

1.23e-041627047d43d59531cbefe3ac94953b7faf7156b2a31441
ToppCelldroplet-Marrow-BM-30m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 LRRK2 STK39 SLC27A4

1.36e-04166704019d365df44c3bbd88c1f4bdceb3de0ff76d3e8d
ToppCellmild-Lymphocytic-B_cells_2|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PLPP5 CIITA TLR7 WDFY4

1.39e-041677040811f7559c2a7151693771e52e14af3978997118
ToppCellMild/Remission-B_naive-4|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

PLPP5 CIITA VAV3 HEATR5B

1.45e-04169704c3a6179a64589a370108fea809b157839347759c
ToppCellCOVID-19-Heart-Adipocyte|Heart / Disease (COVID-19 only), tissue and cell type

TRHDE FASN ACVR1C ELL3

1.45e-04169704bd39f85b48207955f80ca120a11e15a0124117b9
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EMB BST1 WDFY4 ABCC10

1.45e-04169704305cedbd97059029d7d2a248a8a4b6cfe281aa54
ToppCelldroplet-Lung-nan-18m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA TLR3 LRRK2 WDFY4

1.45e-04169704149a4f83da15bdeb170e980fb5b5b1af89ae07a6
ToppCellP28-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FASN EMB LRRK2 HKDC1

1.49e-04170704d0ed3a8a7ad96c05641ec409b0a69c4fb094893c
ToppCelldroplet-Marrow-BM-1m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 LRRK2 LRRC30 SLC27A4

1.52e-041717048a0c08f0aa3a80cd6346c81deb242e430ebd897b
ToppCelldroplet-Liver-nan-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACC1 HKDC1 ACVR1C SKIL

1.55e-04172704f814b6134ad608015765399d54cc1e5e1873ed34
ToppCelldroplet-Liver-nan-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACC1 HKDC1 ACVR1C SKIL

1.55e-041727041f335ccb92b22d0412954e8fc3af212f96410b67
ToppCelldroplet-Marrow-nan-3m-Hematologic-proerythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGM3 BST1 SYNE1 LRRK2

1.55e-04172704cfcfa7eeff1805bedf10a3c07826459914c3e872
ToppCelldroplet-Liver-LIVER-NPC-1m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGM3 CIITA EMB LRRK2

1.55e-04172704a125ac2db9c8ece95970a93aa6f7918d1dcef886
ToppCelldroplet-Liver-nan-3m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACC1 HKDC1 ACVR1C SKIL

1.55e-04172704bb96c896d125e10b71e94e2bdad243899045af5c
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA TLR3 LRRK2 WDFY4

1.55e-04172704a5344760b10ecdc0101f78b93b8fc0f8107068c5
ToppCelldroplet-Liver-LIVER-NPC-1m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGM3 CIITA EMB LRRK2

1.55e-041727046aab59add5b180cee0ca31179c620e89d352d5c1
ToppCelldroplet-Marrow-nan-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 LRRK2 STK39 SLC27A4

1.55e-04172704d354424c1f861b6607dfd63b9724f4c237b30275
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA LRRK2 TLR7 WDFY4

1.62e-041747042f4bc0275cbcaa830d04a4c76e042456908d2277
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA LRRK2 TLR7 WDFY4

1.62e-0417470401eff218e71a04201189a0313aaf91437fffed95
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA LRRK2 TLR7 WDFY4

1.62e-04174704f0f6d135e1fb4c15022be103b00d8d5456515a18
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMG8 COL20A1 TGFBRAP1 SKIL

1.66e-04175704c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCelldroplet-Marrow-nan-21m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 LRRK2 STK39 SLC27A4

1.70e-04176704f7d8eb90489a6d22240179abeb0aa16ac24615d3
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE LRRK2 VAV3 CRHR2

1.70e-0417670440993c41c1017b53039a337174fc56632b278609
ToppCellwk_20-22-Hematologic-Myeloid-Promyelocyte-like|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

EMB LRRK2 GRIN2D SLC27A4

1.70e-04176704ee33d7077a92c1fd371081e7c990c7266e711957
ToppCell3'-Adult-SmallIntestine-Hematopoietic-B_cells-Memory_B|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CIITA EMB LRRK2 WDFY4

1.73e-041777040d1c39e99144fdb9c7f6f98a1ade41c73db45b65
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA BST1 LRRK2 WDFY4

1.77e-04178704ee674e379ee57e40eb2560ff5ed4c13d8db7ed9d
ToppCell3'-Adult-SmallIntestine-Hematopoietic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CIITA EMB LRRK2 WDFY4

1.77e-04178704da1695a936dbe3ca9ee3fb28ceb60511c47b35f8
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TRHDE SLIT2 DUOX2 PAPPA

1.77e-041787048f31b3fac51591f7f2bcb898c07708b3e9f93a16
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA BST1 LRRK2 WDFY4

1.77e-041787046c45bf197d6c1be0ef7d3a644c0062acf1e24e4d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-macrophage|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIITA BST1 LRRK2 WDFY4

1.77e-04178704cd85dcefe94ee742db64b63e105e13532321894a
ToppCell3'-Adult-SmallIntestine-Hematopoietic-B_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CIITA EMB LRRK2 WDFY4

1.77e-04178704580fc1d45b82010c665a313b2e7a21e0116819ef
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CIITA TLR7 ATP13A2 WDFY4

1.81e-04179704c9f45cfea0ceb0cdc31bcfd123aeab69aeb35c35
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EMB TLR7 ATP13A2 WDFY4

1.85e-04180704cc31d2cd06161300b91b17a67bb432b75f0d719b
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC22A6 ARHGEF28 HKDC1 PAPPA

1.85e-04180704864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCellFetal_29-31_weeks-Immune-B_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CIITA EMB VAV3 WDFY4

1.89e-0418170457f20341c3e9f9f6ed5b6c181605ad35bae91414
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TRHDE SLIT2 DUOX2 PAPPA

1.89e-0418170447dce04db3392333eb2f7b9b24c32e6740d2d02f
ToppCellControl-Myeloid-Alveolar_macrophages|Control / group, cell type (main and fine annotations)

TRHDE PCOLCE2 HEATR5B WDFY4

1.89e-041817048d2102c8c86c59a82610f26f90946b290552e666
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TRHDE SLIT2 DUOX2 PAPPA

1.89e-0418170419103221c3a5a16b16378348004b2c50caee4f01
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TRHDE P2RX6 EMB COL20A1

1.89e-04181704fad7ba168f541ac9d04edebc206f191e48bb7e99
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLIT2 MROH2B PAPPA GPR88

1.93e-041827043dfa9187e9d2bab1d199079d29209c4648220ada
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EMB TLR7 ATP13A2 WDFY4

1.93e-0418270494d061b7b5ebbfc564c644bc8b2d52341927145d
DrugMephentermine hemisulfate [1212-72-2]; Down 200; 9.4uM; PC3; HT_HG-U133A

PASK SYNE1 TUBGCP3 CUL9 ALPK1 ATP13A2 INVS

2.55e-061987077384_DN
Diseasecomplement component C6 measurement

EMB MROH2B

3.90e-0413672EFO_0020281
Diseasecaffeine measurement

LRRK2 STK39

5.23e-0415672EFO_0021177
Diseaseperinatal necrotizing enterocolitis (biomarker_via_orthology)

TLR3 TLR7

6.76e-0417672DOID:8677 (biomarker_via_orthology)
Diseaseamino acid measurement

SLIT2 PASK ARHGEF28 SYNE1 GAN STK39 TGM6

8.64e-04678677EFO_0005134
DiseaseNerve Degeneration

LRRK2 GRIN2D ATP13A2

9.03e-0483673C0027746
DiseaseParkinson Disease

BST1 LRRK2 ATP13A2

9.67e-0485673C0030567
DiseaseLiver carcinoma

SLIT2 TGM3 FASN FBXL18 ARID2 DEPDC1

1.03e-03507676C2239176
Diseaseblood pressure

SYNE1 STK39

1.14e-0322672EFO_0004325
DiseaseParkinson disease

LRRK2 ATP13A2

1.14e-0322672cv:C0030567
Diseasecongenital diaphragmatic hernia (biomarker_via_orthology)

SLIT2 KIF7

1.36e-0324672DOID:3827 (biomarker_via_orthology)
DiseaseDisorder of eye

PCARE ATP13A2 INVS KIF7

1.39e-03212674C0015397
Diseaseanogenital venereal wart (is_marker_for)

TLR3 TLR7

1.59e-0326672DOID:11168 (is_marker_for)
DiseaseAutosomal Dominant Parkinsonism

LRRK2 ATP13A2

1.85e-0328672C0752098
DiseaseAutosomal Dominant Juvenile Parkinson Disease

LRRK2 ATP13A2

1.85e-0328672C0752097
DiseaseParkinsonism, Experimental

LRRK2 ATP13A2

1.85e-0328672C0752101
DiseaseAutosomal Recessive Parkinsonism

LRRK2 ATP13A2

1.85e-0328672C0752100
DiseaseFamilial Juvenile Parkinsonism

LRRK2 ATP13A2

1.85e-0328672C0752104
DiseaseRamsay Hunt Paralysis Syndrome

LRRK2 ATP13A2

1.85e-0328672C0242423
DiseasePARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE

LRRK2 ATP13A2

1.85e-0328672C1868675
DiseaseCiliopathies

PCARE INVS KIF7

2.03e-03110673C4277690
DiseaseParkinsonism, Juvenile

LRRK2 ATP13A2

2.12e-0330672C0752105
Diseasemalate measurement

FASN CARD19

2.12e-0330672EFO_0010508
DiseaseParkinsonian Disorders

LRRK2 ATP13A2

2.12e-0330672C0242422
DiseaseOvarian Mucinous Adenocarcinoma

LRRK2 ALPK1

2.26e-0331672C1335167

Protein segments in the cluster

PeptideGeneStartEntry
ALTCSDDRNLLNRLL

TRHDE

891

Q9UKU6
CAASRLLQLLLQLLL

BST1

6

Q10588
QLRLCFTQAARTSLL

ELL3

11

Q9HB65
SLAASLLRLSLYNNC

CIITA

1041

P33076
CSALRQALLLLAAAA

ACVR1C

6

Q8NER5
LAANRTCLRFLLLSA

ARID2

306

Q68CP9
TLALRQRLISSSCRL

PHYKPL

11

Q8IUZ5
LLASLRASILARDCA

ALPK1

91

Q96QP1
ACRLARLLVTQANRL

ARHGEF28

96

Q8N1W1
SLSLGQRQLLCLARA

ABCC10

1381

Q5T3U5
QRQLLCLARALLTDA

ABCC10

1386

Q5T3U5
RNGLSRLCQSRTALS

PASK

51

Q96RG2
LLLSQSRQRIVCLNS

KIAA0100

341

Q14667
RAQRRLSGLSVLLLC

GPR88

276

Q9GZN0
ADLARCAPRLQSLNL

LRRC47

146

Q8N1G4
LLSDRCLQVLNRHLT

DUOX2

666

Q9NRD8
RLRALNNCLSHILAV

OR51Q1

236

Q8NH59
LLFLALRSIRCLRNV

CRHR2

136

Q13324
QLCRSQSLLLRSSTR

DEPDC1

506

Q5TB30
RQRVLRASASLLSQC

KIF7

1066

Q2M1P5
LRRLALDVANNSICL

LRRK2

791

Q5S007
RCLLDSDSRALLNQL

TUBGCP3

761

Q96CW5
LLTLRALQELDLTAC

LRRC29

71

Q8WV35
CRKLRTLLLGDNQLS

LRRC8E

721

Q6NSJ5
CLLLAAATQLSRQQS

PCOLCE2

11

Q9UKZ9
SNSSLRRRLILANCD

PAPPA

401

Q13219
TNLLLTRTLSSCLLN

EXOC6

521

Q8TAG9
LLRALATCHALSRLQ

ATP13A2

551

Q9NQ11
LLRRAAVACLRQLAQ

HEATR5B

1081

Q9P2D3
QRLVCSLSLNRFRLA

BPIFC

396

Q8NFQ6
LLELLASALLALCSR

C6orf47

186

O95873
ALAGLLSRLICQRLQ

COL20A1

346

Q9P218
AALRIANCKLFRLQL

GAN

571

Q9H2C0
LSLDCNLLNVHLRRV

IFNK

26

Q9P0W0
NLFRLLTRDLNCVAS

IFNL2

181

Q8IZJ0
ASLRVRLCDLLSHLQ

CARD19

56

Q96LW7
RQLARSCLDLNTISQ

MACC1

186

Q6ZN28
SELQATRLLCLRSLL

FAM98C

121

Q17RN3
AARNGLLLLNLLLCN

CUL9

866

Q8IWT3
RLLLLQCLLAAARPS

EMB

16

Q6PCB8
QELPRLLSAACRLQL

FASN

1176

P49327
LRCISLTNLALSRRS

EGFEM1P

141

Q0D2K5
LVCSHRALRQLAQSL

SLC22A6

126

Q4U2R8
RSLCLVTSLELLNLN

LRRC30

226

A6NM36
LALASQARLAECLRR

P2RX6

391

O15547
LRADSQRRAALCALN

PCARE

1171

A6NGG8
LRLNSVSNLQCIHLL

INVS

1026

Q9Y283
LLLTSICDNSQLLRA

SMG8

151

Q8ND04
ITLTDAQRLCNALLR

SKIL

221

P12757
RLCSQLLTSHQNLLR

SYNE1

2596

Q8NF91
CAAALAAILTRLREN

HKDC1

386

Q2TB90
LSVCERLNLALSLSL

NKX1-1

321

Q15270
CQLLARLRHLRSLSL

FBXL18

406

Q96ME1
CQLALELLASAARLL

RNF26

206

Q9BY78
SLRRSIFINLLQQIC

MROH2B

271

Q7Z745
FSSALCAARLLRQRL

PDXP

86

Q96GD0
LSICLSILDRSLNFR

TGM3

186

Q08188
AQCSFILLLSIIRAR

TEPP

6

Q6URK8
LRSCLLISVASLNFL

PIGV

111

Q9NUD9
ELRAASALNRLLVLC

TGFBRAP1

81

Q8WUH2
LCLELANTSIRNLSL

TLR3

241

O15455
NSACLHLRKLLLLSR

TLCD2

141

A6NGC4
INTNLRRDALLHCLT

SLC27A4

156

Q6P1M0
NRVLLSNLQRCDLAS

SOGA1

356

O94964
RLLAAFLLLAAQVAC

SPPL2B

11

Q8TCT7
RLRELSLRNNALSAL

TRIL

326

Q7L0X0
SRQACLAASLALALN

PLPP5

86

Q8NEB5
ATDCVRLSLQNLSRL

WDFY4

261

Q6ZS81
TQLLTLILSYNRLRC

SLIT2

801

O94813
ERLSNCSRSLKNLIL

TLR7

716

Q9NYK1
EASSCAVNLVLRLRN

STK39

446

Q9UEW8
LRLALCLANLTSRAQ

TGM6

511

O95932
QRALLANALTSALRL

TMEM33

56

P57088
VLLCQLLNNLRAHSI

VAV3

41

Q9UKW4
LRSVSAQIRLLFCAR

GRIN2D

236

O15399