Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC24A5 CACNA1A SLC43A2 CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 TPCN2 SLC24A4 SLC15A2 ATP6V0A4 SIDT1 SLC44A2 LRRC8A KCNE5 TRPV6 SERINC5 SLC30A4 TRPV5 ITPR1 SLC35B1 ITPR2 SLC5A3	9.51e-13	1180	71	24	GO:0022857
GeneOntologyMolecularFunction	calcium channel activity	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 SLC24A4 TRPV6 TRPV5 ITPR1 ITPR2	9.78e-13	129	71	11	GO:0005262
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 TPCN2 SLC24A4 SLC15A2 ATP6V0A4 KCNE5 TRPV6 SLC30A4 TRPV5 ITPR1 ITPR2 SLC5A3	4.56e-12	627	71	18	GO:0022890
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 SLC24A4 TRPV6 TRPV5 ITPR1 ITPR2	5.55e-12	151	71	11	GO:0015085
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 TPCN2 SLC24A4 KCNE5 TRPV6 SLC30A4 TRPV5 ITPR1 ITPR2 SLC5A3	5.72e-12	465	71	16	GO:0046873
GeneOntologyMolecularFunction	transporter activity	SLC24A5 CACNA1A SLC43A2 CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 TPCN2 SLC24A4 SLC15A2 ATP6V0A4 SIDT1 SLC44A2 LRRC8A KCNE5 TRPV6 SERINC5 SLC30A4 TRPV5 ITPR1 SLC35B1 ITPR2 SLC5A3	6.23e-12	1289	71	24	GO:0005215
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 TPCN2 SLC24A4 SLC15A2 ATP6V0A4 KCNE5 TRPV6 SLC30A4 TRPV5 ITPR1 ITPR2 SLC5A3	1.18e-11	664	71	18	GO:0008324
GeneOntologyMolecularFunction	G protein-coupled receptor activity	ADRA1B ADRA1A OR2A7 ADRA2A OR2A4 OR10Q1 OR1E1 OR1E2 LGR4 OR5K4 HRH2 TAAR1 GPR171 TACR3 OR51V1 F2RL2 NPFFR1 OR51B2 CX3CR1 OR1J2	1.79e-11	884	71	20	GO:0004930
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 TPCN2 SLC24A4 SLC15A2 ATP6V0A4 LRRC8A KCNE5 TRPV6 SLC30A4 TRPV5 ITPR1 ITPR2 SLC5A3	2.40e-11	793	71	19	GO:0015075
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 TPCN2 SLC24A4 SLC15A2 ATP6V0A4 KCNE5 TRPV6 SLC30A4 TRPV5 ITPR1 ITPR2 SLC5A3	1.03e-10	758	71	18	GO:0015318
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	ADRA1B ADRA1A OR2A7 ADRA2A NRXN3 NRXN2 IL1RAPL2 OR2A4 OR10Q1 OR1E1 OR1E2 LGR4 OR5K4 HRH2 TAAR1 GPR171 TACR3 OR51V1 F2RL2 NPFFR1 OR51B2 CX3CR1 OR1J2	1.22e-10	1353	71	23	GO:0004888
GeneOntologyMolecularFunction	monoatomic ion channel activity	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC9C1 TPCN2 SLC24A4 LRRC8A KCNE5 TRPV6 TRPV5 ITPR1 ITPR2	6.88e-10	459	71	14	GO:0005216
GeneOntologyMolecularFunction	monoatomic cation channel activity	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 SLC24A4 KCNE5 TRPV6 TRPV5 ITPR1 ITPR2	2.81e-09	343	71	12	GO:0005261
GeneOntologyMolecularFunction	channel activity	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC9C1 TPCN2 SLC24A4 LRRC8A KCNE5 TRPV6 TRPV5 ITPR1 ITPR2	3.87e-09	525	71	14	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC9C1 TPCN2 SLC24A4 LRRC8A KCNE5 TRPV6 TRPV5 ITPR1 ITPR2	3.96e-09	526	71	14	GO:0022803
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1A CACNA1B CACNA1E CACNA1S	1.43e-07	14	71	4	GO:0008331
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	ADRA1B ADRA1A ADRA2A HRH2 TAAR1	3.34e-07	41	71	5	GO:0008227
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2	6.03e-07	46	71	5	GO:0005245
GeneOntologyMolecularFunction	alpha-adrenergic receptor activity	ADRA1B ADRA1A ADRA2A	8.55e-07	6	71	3	GO:0004936
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC24A5 SLC6A12 SLC9C1 SLC24A4 SLC15A2 SLC44A2 SLC30A4 SLC35B1 SLC5A3	1.02e-06	296	71	9	GO:0015291
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1A CACNA1B CACNA1E	3.56e-06	9	71	3	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1A CACNA1B CACNA1E	3.56e-06	9	71	3	GO:0099626
GeneOntologyMolecularFunction	adrenergic receptor activity	ADRA1B ADRA1A ADRA2A	5.08e-06	10	71	3	GO:0004935
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC24A5 SLC6A12 SLC9C1 SLC24A4 SLC15A2 ATP6V0A4 SLC44A2 SLC30A4 SLC35B1 SLC5A3	6.90e-06	477	71	10	GO:0022804
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	LGR4 GPR171 TACR3 F2RL2 NPFFR1 CX3CR1	7.83e-06	133	71	6	GO:0008528
GeneOntologyMolecularFunction	antiporter activity	SLC24A5 SLC9C1 SLC24A4 SLC44A2 SLC30A4 SLC35B1	9.68e-06	138	71	6	GO:0015297
GeneOntologyMolecularFunction	peptide receptor activity	LGR4 GPR171 TACR3 F2RL2 NPFFR1 CX3CR1	1.05e-05	140	71	6	GO:0001653
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 KCNE5	1.68e-05	152	71	6	GO:0022843
GeneOntologyMolecularFunction	olfactory receptor activity	OR2A7 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2 OR1J2	2.13e-05	431	71	9	GO:0004984
GeneOntologyMolecularFunction	gated channel activity	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 KCNE5 ITPR1 ITPR2	2.40e-05	334	71	8	GO:0022836
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC24A5 SLC6A12 SLC9C1 TPCN2 SLC24A4 SLC5A3	3.26e-05	171	71	6	GO:0015081
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	TPCN2 ITPR1 ITPR2	3.38e-05	18	71	3	GO:0015278
GeneOntologyMolecularFunction	ceramide phosphoethanolamine synthase activity	SGMS2 SGMS1	3.73e-05	3	71	2	GO:0002950
GeneOntologyMolecularFunction	ceramide cholinephosphotransferase activity	SGMS2 SGMS1	3.73e-05	3	71	2	GO:0047493
GeneOntologyMolecularFunction	alpha1-adrenergic receptor activity	ADRA1B ADRA1A	3.73e-05	3	71	2	GO:0004937
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR2	3.73e-05	3	71	2	GO:0005220
GeneOntologyMolecularFunction	sphingomyelin synthase activity	SGMS2 SGMS1	3.73e-05	3	71	2	GO:0033188
GeneOntologyMolecularFunction	solute:potassium antiporter activity	SLC24A5 SLC9C1 SLC24A4	4.01e-05	19	71	3	GO:0022821
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 KCNE5	4.63e-05	182	71	6	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 KCNE5	4.92e-05	184	71	6	GO:0022832
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC24A5 SLC6A12 SLC9C1 SLC24A4 SLC15A2 ATP6V0A4 SLC5A3	9.61e-05	301	71	7	GO:0022853
GeneOntologyMolecularFunction	calcium, potassium:sodium antiporter activity	SLC24A5 SLC24A4	1.24e-04	5	71	2	GO:0008273
GeneOntologyMolecularFunction	neuroligin family protein binding	NRXN3 NRXN2	1.24e-04	5	71	2	GO:0097109
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	TPCN2 ITPR1 ITPR2	1.80e-04	31	71	3	GO:0099604
GeneOntologyMolecularFunction	symporter activity	SLC24A5 SLC6A12 SLC24A4 SLC15A2 SLC5A3	1.95e-04	150	71	5	GO:0015293
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	TPCN2 ITPR1 ITPR2	2.18e-04	33	71	3	GO:0005217
GeneOntologyMolecularFunction	ion channel regulator activity	NRXN3 NRXN2 KCNE5 ITPR1 SLC5A3	2.79e-04	162	71	5	GO:0099106
GeneOntologyMolecularFunction	channel regulator activity	NRXN3 NRXN2 KCNE5 ITPR1 SLC5A3	3.88e-04	174	71	5	GO:0016247
GeneOntologyMolecularFunction	transporter regulator activity	NRXN3 NRXN2 KCNE5 ITPR1 SLC5A3	4.20e-04	177	71	5	GO:0141108
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC24A5 SLC9C1 SLC24A4	4.80e-04	43	71	3	GO:0140828
GeneOntologyMolecularFunction	calcium:sodium antiporter activity	SLC24A5 SLC24A4	5.51e-04	10	71	2	GO:0005432
GeneOntologyMolecularFunction	neuropeptide receptor activity	GPR171 TACR3 NPFFR1	8.88e-04	53	71	3	GO:0008188
GeneOntologyMolecularFunction	calcium channel regulator activity	NRXN3 NRXN2 ITPR1	9.38e-04	54	71	3	GO:0005246
GeneOntologyMolecularFunction	calcium:monoatomic cation antiporter activity	SLC24A5 SLC24A4	9.48e-04	13	71	2	GO:0015368
GeneOntologyMolecularFunction	odorant binding	OR2A7 OR2A4 OR10Q1 OR5K4	1.09e-03	127	71	4	GO:0005549
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	ITPR1 ITPR2	1.10e-03	14	71	2	GO:0070679
GeneOntologyMolecularFunction	nucleobase-containing compound transmembrane transporter activity	SIDT1 LRRC8A SLC35B1	1.21e-03	59	71	3	GO:0015932
GeneOntologyMolecularFunction	calmodulin binding	CACNA1A CACNA1S SLC24A4 TRPV6 TRPV5	1.36e-03	230	71	5	GO:0005516
GeneOntologyMolecularFunction	phosphotransferase activity, for other substituted phosphate groups	SGMS2 SGMS1	2.75e-03	22	71	2	GO:0016780
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	SLC24A5 SLC9C1 SLC24A4 KCNE5	2.97e-03	167	71	4	GO:0015079
GeneOntologyMolecularFunction	purine ribonucleotide transmembrane transporter activity	LRRC8A SLC35B1	3.01e-03	23	71	2	GO:0005346
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC43A2 SLC44A2 SERINC5	3.23e-03	83	71	3	GO:0015101
GeneOntologyMolecularFunction	transmembrane transporter binding	KCNE5 ITPR1 ITPR2 SLC5A3	3.30e-03	172	71	4	GO:0044325
GeneOntologyMolecularFunction	adenine nucleotide transmembrane transporter activity	LRRC8A SLC35B1	3.83e-03	26	71	2	GO:0000295
GeneOntologyMolecularFunction	protein-cysteine S-palmitoyltransferase activity	ZDHHC11B ZDHHC11	3.83e-03	26	71	2	GO:0019706
GeneOntologyMolecularFunction	protein-cysteine S-acyltransferase activity	ZDHHC11B ZDHHC11	3.83e-03	26	71	2	GO:0019707
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC43A2 SLC6A12 LRRC8A SERINC5 SLC35B1	3.89e-03	293	71	5	GO:0008514
GeneOntologyMolecularFunction	purine nucleotide transmembrane transporter activity	LRRC8A SLC35B1	4.76e-03	29	71	2	GO:0015216
GeneOntologyMolecularFunction	S-acyltransferase activity	ZDHHC11B ZDHHC11	5.08e-03	30	71	2	GO:0016417
GeneOntologyMolecularFunction	alcohol binding	SIDT1 ITPR1 ITPR2	5.75e-03	102	71	3	GO:0043178
GeneOntologyMolecularFunction	nucleotide transmembrane transporter activity	LRRC8A SLC35B1	6.13e-03	33	71	2	GO:0015215
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	SLC43A2 SLC6A12 SERINC5	6.23e-03	105	71	3	GO:0015171
GeneOntologyMolecularFunction	palmitoyltransferase activity	ZDHHC11B ZDHHC11	7.66e-03	37	71	2	GO:0016409
GeneOntologyMolecularFunction	organophosphate ester transmembrane transporter activity	LRRC8A SLC35B1	8.48e-03	39	71	2	GO:0015605
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC6A12 SLC15A2 SLC5A3	8.79e-03	119	71	3	GO:0015294
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 ADRA1A ADRA2A TPCN2 SLC24A4 SLC15A2 ATP6V0A4 LRRC8A KCNE5 TRPV6 SLC30A4 TRPV5 ITPR1 ITPR2 SLC5A3	1.51e-11	1017	71	21	GO:0098660
GeneOntologyBiologicalProcess	import across plasma membrane	CACNA1A SLC43A2 CACNA1B CACNA1E CACNA1S SLC9C1 SLC24A4 SLC15A2 LRRC8A TRPV6 TRPV5 SLC5A3	1.99e-11	230	71	12	GO:0098739
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 ADRA1A ADRA2A TPCN2 SLC24A4 SLC15A2 ATP6V0A4 KCNE5 TRPV6 SLC30A4 TRPV5 ITPR1 ITPR2 SLC5A3	2.14e-11	922	71	20	GO:0098662
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 ADRA1A ADRA2A TPCN2 SLC24A4 SLC15A2 ATP6V0A4 KCNE5 TRPV6 SLC30A4 TRPV5 ITPR1 ITPR2 SLC5A3	3.15e-11	942	71	20	GO:0098655
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 ADRA1A ADRA2A TPCN2 SLC24A4 SLC15A2 ATP6V0A4 LRRC8A KCNE5 TRPV6 SLC30A4 TRPV5 ITPR1 ITPR2 SLC5A3	8.38e-11	1115	71	21	GO:0034220
GeneOntologyBiologicalProcess	calcium ion transmembrane import into cytosol	CACNA1A CACNA1B CACNA1E CACNA1S ADRA1A TPCN2 SLC24A4 TRPV6 TRPV5 ITPR1 ITPR2	2.00e-10	217	71	11	GO:0097553
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	CACNA1A CACNA1B CACNA1E CACNA1S SLC24A4 TRPV6 TRPV5	2.78e-10	48	71	7	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	CACNA1A CACNA1B CACNA1E CACNA1S SLC24A4 TRPV6 TRPV5	2.78e-10	48	71	7	GO:1902656
GeneOntologyBiologicalProcess	calcium ion transmembrane transport	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S ADRA1A ADRA2A TPCN2 SLC24A4 TRPV6 TRPV5 ITPR1 ITPR2	7.42e-10	392	71	13	GO:0070588
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	ADRA1B ADRA1A OR2A7 ADRA2A SLC24A4 OR2A4 OR10Q1 OR1E1 OR1E2 LGR4 OR5K4 HRH2 TAAR1 GPR171 TACR3 OR51V1 F2RL2 NPFFR1 OR51B2 CX3CR1 OR1J2 ITPR1	7.81e-10	1395	71	22	GO:0007186
GeneOntologyBiologicalProcess	monoatomic cation transport	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 ADRA1A ADRA2A TPCN2 SLC24A4 SLC15A2 ATP6V0A4 KCNE5 TRPV6 SLC30A4 TRPV5 ITPR1 ITPR2 SLC5A3	1.18e-09	1157	71	20	GO:0006812
GeneOntologyBiologicalProcess	calcium ion import	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC24A4 TRPV6 TRPV5	1.62e-09	98	71	8	GO:0070509
GeneOntologyBiologicalProcess	monoatomic ion transport	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 ADRA1A ADRA2A TPCN2 SLC24A4 SLC15A2 ATP6V0A4 LRRC8A KCNE5 TRPV6 SLC30A4 TRPV5 ITPR1 ITPR2 SLC5A3	3.71e-09	1374	71	21	GO:0006811
GeneOntologyBiologicalProcess	metal ion transport	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 ADRA1A ADRA2A TPCN2 SLC24A4 KCNE5 TRPV6 SLC30A4 TRPV5 ITPR1 ITPR2 SLC5A3	5.11e-09	1000	71	18	GO:0030001
GeneOntologyBiologicalProcess	calcium ion transport	SLC24A5 CACNA1A CACNA1B CACNA1E CACNA1S ADRA1A ADRA2A TPCN2 SLC24A4 TRPV6 TRPV5 ITPR1 ITPR2	1.70e-08	509	71	13	GO:0006816
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	CACNA1A CACNA1B CACNA1E CACNA1S SLC9C1 SLC24A4 TRPV6 TRPV5	3.05e-08	142	71	8	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	CACNA1A CACNA1B CACNA1E CACNA1S SLC9C1 SLC24A4 TRPV6 TRPV5	3.05e-08	142	71	8	GO:0098659
GeneOntologyBiologicalProcess	chemical homeostasis	SLC24A5 CACNA1A CACNA1E CACNA1S SLC6A12 SLC9C1 ADRA1B ADRA2A TPCN2 SLC24A4 ATP6V0A4 LRRC8A TRPV6 XK CYP39A1 TRPV5 ITPR1 ITPR2	1.53e-07	1249	71	18	GO:0048878
GeneOntologyBiologicalProcess	cellular homeostasis	SLC24A5 CACNA1A CACNA1E CACNA1S SLC6A12 SLC9C1 ADRA2A TPCN2 SLC24A4 ATP6V0A4 LRRC8A XK MSTN TRPV5 ITPR1 ITPR2	1.65e-07	981	71	16	GO:0019725
GeneOntologyBiologicalProcess	intracellular chemical homeostasis	SLC24A5 CACNA1A CACNA1E CACNA1S SLC6A12 SLC9C1 ADRA2A TPCN2 SLC24A4 ATP6V0A4 LRRC8A XK TRPV5 ITPR1 ITPR2	2.00e-07	866	71	15	GO:0055082
GeneOntologyBiologicalProcess	calcium ion homeostasis	SLC24A5 CACNA1A CACNA1S TPCN2 SLC24A4 TRPV6 XK TRPV5 ITPR1 ITPR2	8.41e-07	389	71	10	GO:0055074
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2A7 SLC24A4 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2 OR1J2	2.16e-06	432	71	10	GO:0050911
GeneOntologyBiologicalProcess	sensory perception	CACNA1E OR2A7 ADRA2A SLC24A4 ELFN1 OR2A4 ATP6V0A4 OR10Q1 OR1E1 OR1E2 OR5K4 GPR171 OR51V1 OR51B2 OR1J2	2.92e-06	1072	71	15	GO:0007600
GeneOntologyBiologicalProcess	intracellular calcium ion homeostasis	SLC24A5 CACNA1A CACNA1S TPCN2 SLC24A4 XK TRPV5 ITPR1 ITPR2	3.82e-06	359	71	9	GO:0006874
GeneOntologyBiologicalProcess	sensory perception of smell	OR2A7 SLC24A4 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2 OR1J2	4.16e-06	465	71	10	GO:0007608
GeneOntologyBiologicalProcess	monoatomic cation homeostasis	SLC24A5 CACNA1A CACNA1S SLC9C1 TPCN2 SLC24A4 ATP6V0A4 TRPV6 XK TRPV5 ITPR1 ITPR2	4.67e-06	705	71	12	GO:0055080
GeneOntologyBiologicalProcess	monoatomic ion homeostasis	SLC24A5 CACNA1A CACNA1S SLC9C1 TPCN2 SLC24A4 ATP6V0A4 TRPV6 XK TRPV5 ITPR1 ITPR2	5.54e-06	717	71	12	GO:0050801
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2A7 SLC24A4 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2 OR1J2	6.02e-06	485	71	10	GO:0050907
GeneOntologyBiologicalProcess	phospholipase C-activating G protein-coupled receptor signaling pathway	ADRA1B ADRA1A ADRA2A F2RL2 CX3CR1 ITPR1	6.52e-06	133	71	6	GO:0007200
GeneOntologyBiologicalProcess	regulation of system process	CACNA1B CACNA1E CACNA1S ADRA1B ADRA1A ADRA2A NRXN2 HRH2 KCNE5 GPR171 TACR3 MSTN	7.03e-06	734	71	12	GO:0044057
GeneOntologyBiologicalProcess	export from cell	CACNA1A CACNA1B CACNA1E ADRA2A TPCN2 NRXN3 SLC24A4 NRXN2 SLC15A2 LRRC8A KCNE5 TRPV6 SLC30A4 F2RL2 ITPR1	7.07e-06	1153	71	15	GO:0140352
GeneOntologyBiologicalProcess	intracellular monoatomic cation homeostasis	SLC24A5 CACNA1A CACNA1S SLC9C1 TPCN2 SLC24A4 ATP6V0A4 XK TRPV5 ITPR1 ITPR2	7.19e-06	611	71	11	GO:0030003
GeneOntologyBiologicalProcess	intracellular monoatomic ion homeostasis	SLC24A5 CACNA1A CACNA1S SLC9C1 TPCN2 SLC24A4 ATP6V0A4 XK TRPV5 ITPR1 ITPR2	8.51e-06	622	71	11	GO:0006873
GeneOntologyBiologicalProcess	organic cation transport	CACNA1A SLC43A2 SLC6A12 ADRA2A SLC44A2 SERINC5	1.07e-05	145	71	6	GO:0015695
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2A7 SLC24A4 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2 OR1J2	1.18e-05	524	71	10	GO:0009593
GeneOntologyBiologicalProcess	import into cell	CACNA1A SLC43A2 CACNA1B CACNA1E CACNA1S SLC6A12 SLC9C1 TPCN2 SLC24A4 SLC15A2 LRRC8A TRPV6 TRPV5 SLC5A3	1.47e-05	1074	71	14	GO:0098657
GeneOntologyBiologicalProcess	regulation of blood circulation	CACNA1B CACNA1E ADRA1B ADRA1A ADRA2A HRH2 KCNE5 TACR3	1.60e-05	326	71	8	GO:1903522
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2A7 SLC24A4 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2 OR1J2	1.71e-05	547	71	10	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2A7 SLC24A4 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2 OR1J2	2.91e-05	582	71	10	GO:0050906
GeneOntologyBiologicalProcess	inorganic ion homeostasis	SLC24A5 CACNA1A CACNA1S TPCN2 SLC24A4 TRPV6 XK TRPV5 ITPR1 ITPR2	5.10e-05	622	71	10	GO:0098771
GeneOntologyBiologicalProcess	amino acid transport	CACNA1A SLC43A2 SLC6A12 LRRC8A XK SERINC5	5.68e-05	195	71	6	GO:0006865
GeneOntologyBiologicalProcess	muscle contraction	CACNA1S SSPN ADRA1B ADRA1A ADRA2A TPCN2 KCNE5 TACR3	6.83e-05	400	71	8	GO:0006936
GeneOntologyBiologicalProcess	positive regulation of heart rate by epinephrine-norepinephrine	ADRA1B ADRA1A	6.98e-05	4	71	2	GO:0001996
GeneOntologyBiologicalProcess	positive regulation of the force of heart contraction by epinephrine-norepinephrine	ADRA1B ADRA1A	6.98e-05	4	71	2	GO:0001997
GeneOntologyBiologicalProcess	signal release	CACNA1A CACNA1B CACNA1E ADRA2A NRXN3 NRXN2 LRRC8A TRPV6 F2RL2 ITPR1	7.64e-05	653	71	10	GO:0023061
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SLC24A5 SLC6A12 SLC9C1 TPCN2 SLC24A4 SLC5A3	8.12e-05	208	71	6	GO:0035725
GeneOntologyBiologicalProcess	regulation of heart rate	CACNA1E ADRA1B ADRA1A KCNE5 TACR3	8.28e-05	129	71	5	GO:0002027
GeneOntologyBiologicalProcess	presynaptic modulation of chemical synaptic transmission	ADRA1A ADRA2A NRXN3 NRXN2	8.39e-05	67	71	4	GO:0099171
GeneOntologyBiologicalProcess	adenylate cyclase-activating adrenergic receptor signaling pathway	ADRA1B ADRA1A ADRA2A	8.51e-05	25	71	3	GO:0071880
GeneOntologyBiologicalProcess	modulation of chemical synaptic transmission	CACNA1A CACNA1B CACNA1E ADRA1A ADRA2A NRXN3 NRXN2 RNF19A HRH2 CX3CR1	8.67e-05	663	71	10	GO:0050804
GeneOntologyBiologicalProcess	regulation of trans-synaptic signaling	CACNA1A CACNA1B CACNA1E ADRA1A ADRA2A NRXN3 NRXN2 RNF19A HRH2 CX3CR1	8.78e-05	664	71	10	GO:0099177
GeneOntologyBiologicalProcess	muscle system process	CACNA1S SSPN ADRA1B ADRA1A ADRA2A TPCN2 KCNE5 TACR3 MSTN	1.05e-04	547	71	9	GO:0003012
GeneOntologyBiologicalProcess	synaptic signaling	CACNA1A CACNA1B CACNA1E ADRA1A ADRA2A NRXN3 NRXN2 RNF19A ELFN1 HRH2 CX3CR1 ITPR1	1.14e-04	976	71	12	GO:0099536
GeneOntologyBiologicalProcess	neuron-glial cell signaling	ADRA1B ADRA1A	1.16e-04	5	71	2	GO:0150099
GeneOntologyBiologicalProcess	positive regulation of the force of heart contraction by chemical signal	ADRA1B ADRA1A	1.16e-04	5	71	2	GO:0003099
GeneOntologyBiologicalProcess	positive regulation of cytosolic calcium ion concentration	CACNA1A ADRA1B ADRA1A TRPV5 CX3CR1 ITPR1	1.22e-04	224	71	6	GO:0007204
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback	ADRA1B ADRA1A	1.74e-04	6	71	2	GO:0001978
GeneOntologyBiologicalProcess	detection of stimulus	OR2A7 SLC24A4 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2 OR1J2	1.74e-04	722	71	10	GO:0051606
GeneOntologyBiologicalProcess	circulatory system process	CACNA1B CACNA1E ADRA1B ADRA1A ADRA2A SLC15A2 HRH2 KCNE5 TACR3 SLC5A3	1.97e-04	733	71	10	GO:0003013
GeneOntologyBiologicalProcess	regulation of heart contraction	CACNA1B CACNA1E ADRA1B ADRA1A KCNE5 TACR3	2.17e-04	249	71	6	GO:0008016
GeneOntologyBiologicalProcess	behavior	CACNA1A CACNA1B CACNA1E ADRA1B NRXN3 SLC24A4 NRXN2 HRH2 GPR171 TACR3 CX3CR1	2.19e-04	891	71	11	GO:0007610
GeneOntologyBiologicalProcess	positive regulation of heart rate	ADRA1B ADRA1A TACR3	2.36e-04	35	71	3	GO:0010460
GeneOntologyBiologicalProcess	adrenergic receptor signaling pathway	ADRA1B ADRA1A ADRA2A	2.36e-04	35	71	3	GO:0071875
GeneOntologyBiologicalProcess	positive regulation of blood pressure by epinephrine-norepinephrine	ADRA1B ADRA1A	2.43e-04	7	71	2	GO:0003321
GeneOntologyBiologicalProcess	neurotransmitter transport	CACNA1A CACNA1B CACNA1E SLC6A12 NRXN3 NRXN2	2.68e-04	259	71	6	GO:0006836
GeneOntologyBiologicalProcess	export across plasma membrane	SLC24A4 SLC15A2 KCNE5 SLC30A4	2.75e-04	91	71	4	GO:0140115
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by norepinephrine-epinephrine	ADRA1B ADRA1A	3.23e-04	8	71	2	GO:0001993
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by baroreceptor feedback	ADRA1B ADRA1A	3.23e-04	8	71	2	GO:0003025
GeneOntologyBiologicalProcess	regulation of the force of heart contraction by chemical signal	ADRA1B ADRA1A	3.23e-04	8	71	2	GO:0003057
GeneOntologyBiologicalProcess	regulation of vasoconstriction	ADRA1B ADRA1A ADRA2A HRH2	3.65e-04	98	71	4	GO:0019229
GeneOntologyBiologicalProcess	sodium ion transport	SLC24A5 SLC6A12 SLC9C1 TPCN2 SLC24A4 SLC5A3	3.69e-04	275	71	6	GO:0006814
GeneOntologyBiologicalProcess	regulation of secretion	CACNA1A CACNA1B CACNA1E ADRA2A TPCN2 LRRC8A HRH2 TRPV6 F2RL2 ITPR1	3.99e-04	801	71	10	GO:0051046
GeneOntologyBiologicalProcess	central nervous system maturation	CACNA1A CX3CR1	4.14e-04	9	71	2	GO:0021626
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ADRA1B ADRA1A ADRA2A LGR4 TAAR1 GPR171	4.54e-04	286	71	6	GO:0007188
GeneOntologyBiologicalProcess	regulation of calcium ion-dependent exocytosis	CACNA1A ADRA2A TRPV6	5.00e-04	45	71	3	GO:0017158
GeneOntologyBiologicalProcess	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ADRA1B ADRA1A ADRA2A LGR4 TAAR1	5.13e-04	191	71	5	GO:0007189
GeneOntologyBiologicalProcess	signal release from synapse	CACNA1A CACNA1B CACNA1E NRXN3 NRXN2	5.63e-04	195	71	5	GO:0099643
GeneOntologyBiologicalProcess	neurotransmitter secretion	CACNA1A CACNA1B CACNA1E NRXN3 NRXN2	5.63e-04	195	71	5	GO:0007269
GeneOntologyBiologicalProcess	heart contraction	CACNA1B CACNA1E ADRA1B ADRA1A KCNE5 TACR3	5.64e-04	298	71	6	GO:0060047
GeneOntologyBiologicalProcess	sphingomyelin biosynthetic process	SGMS2 SGMS1	6.30e-04	11	71	2	GO:0006686
GeneOntologyBiologicalProcess	positive regulation of heart contraction	ADRA1B ADRA1A TACR3	6.43e-04	49	71	3	GO:0045823
GeneOntologyBiologicalProcess	regulation of muscle contraction	CACNA1S ADRA1B ADRA1A ADRA2A TACR3	6.61e-04	202	71	5	GO:0006937
GeneOntologyBiologicalProcess	heart process	CACNA1B CACNA1E ADRA1B ADRA1A KCNE5 TACR3	6.81e-04	309	71	6	GO:0003015
GeneOntologyBiologicalProcess	response to pain	CACNA1A CACNA1B CACNA1E	7.23e-04	51	71	3	GO:0048265
GeneOntologyBiologicalProcess	regulation of uterine smooth muscle contraction	ADRA2A TACR3	7.54e-04	12	71	2	GO:0070472
GeneOntologyBiologicalProcess	regulation of muscle system process	CACNA1S ADRA1B ADRA1A ADRA2A TACR3 MSTN	7.78e-04	317	71	6	GO:0090257
GeneOntologyBiologicalProcess	vasoconstriction	ADRA1B ADRA1A ADRA2A HRH2	8.08e-04	121	71	4	GO:0042310
GeneOntologyBiologicalProcess	positive regulation of blood circulation	ADRA1B ADRA1A TACR3	8.09e-04	53	71	3	GO:1903524
GeneOntologyBiologicalProcess	learning	CACNA1E ADRA1B NRXN3 NRXN2 HRH2	8.22e-04	212	71	5	GO:0007612
GeneOntologyBiologicalProcess	secretion	CACNA1A CACNA1B CACNA1E ADRA2A TPCN2 NRXN3 NRXN2 LRRC8A HRH2 TRPV6 F2RL2 ITPR1	8.74e-04	1221	71	12	GO:0046903
GeneOntologyBiologicalProcess	uterine smooth muscle contraction	ADRA2A TACR3	8.89e-04	13	71	2	GO:0070471
GeneOntologyBiologicalProcess	multicellular organismal response to stress	CACNA1A CACNA1B CACNA1E ADRA2A	9.40e-04	126	71	4	GO:0033555
GeneOntologyBiologicalProcess	regulation of secretion by cell	CACNA1A CACNA1B CACNA1E ADRA2A TPCN2 LRRC8A TRPV6 F2RL2 ITPR1	9.56e-04	740	71	9	GO:1903530
GeneOntologyBiologicalProcess	secretion by cell	CACNA1A CACNA1B CACNA1E ADRA2A TPCN2 NRXN3 NRXN2 LRRC8A TRPV6 F2RL2 ITPR1	9.73e-04	1064	71	11	GO:0032940
GeneOntologyBiologicalProcess	positive regulation of blood pressure	ADRA1B ADRA1A TACR3	1.11e-03	59	71	3	GO:0045777
GeneOntologyBiologicalProcess	positive regulation of muscle contraction	CACNA1S ADRA1A TACR3	1.11e-03	59	71	3	GO:0045933
GeneOntologyBiologicalProcess	smooth muscle contraction	ADRA1A ADRA2A TPCN2 TACR3	1.15e-03	133	71	4	GO:0006939
GeneOntologyBiologicalProcess	vascular process in circulatory system	ADRA1B ADRA1A ADRA2A SLC15A2 HRH2 SLC5A3	1.19e-03	344	71	6	GO:0003018
GeneOntologyBiologicalProcess	pre-B cell differentiation	LRRC8A LAPTM5	1.19e-03	15	71	2	GO:0002329
GeneOntologyBiologicalProcess	regulation of insulin secretion	CACNA1E ADRA2A LRRC8A F2RL2 ITPR1	1.20e-03	231	71	5	GO:0050796
GeneOntologyCellularComponent	calcium channel complex	CACNA1A CACNA1B CACNA1E CACNA1S TRPV6 TRPV5	1.76e-07	73	71	6	GO:0034704
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 LRRC8A KCNE5 TRPV6 TRPV5 SLC5A3	5.75e-07	378	71	10	GO:0034702
GeneOntologyCellularComponent	cation channel complex	CACNA1A CACNA1B CACNA1E CACNA1S KCNE5 TRPV6 TRPV5 SLC5A3	1.31e-06	235	71	8	GO:0034703
GeneOntologyCellularComponent	transmembrane transporter complex	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 ATP6V0A4 LRRC8A KCNE5 TRPV6 TRPV5 SLC5A3	1.43e-06	523	71	11	GO:1902495
GeneOntologyCellularComponent	transporter complex	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 ATP6V0A4 LRRC8A KCNE5 TRPV6 TRPV5 SLC5A3	2.32e-06	550	71	11	GO:1990351
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1A CACNA1B CACNA1E CACNA1S	1.79e-05	46	71	4	GO:0005891
GeneOntologyCellularComponent	presynaptic active zone	CACNA1A CACNA1B ADRA2A NRXN3 NRXN2	1.18e-04	141	71	5	GO:0048786
GeneOntologyCellularComponent	presynaptic active zone membrane	CACNA1A ADRA2A NRXN3 NRXN2	1.44e-04	78	71	4	GO:0048787
GeneOntologyCellularComponent	synaptic membrane	CACNA1A CACNA1E SSPN ADRA1A ADRA2A NRXN3 NRXN2 ELFN1 ITPR1	1.53e-04	583	71	9	GO:0097060
GeneOntologyCellularComponent	presynapse	CACNA1A CACNA1B CACNA1E SLC6A12 ADRA1A ADRA2A NRXN3 NRXN2 ELFN1 ATP6V0A4 ITPR1	1.86e-04	886	71	11	GO:0098793
GeneOntologyCellularComponent	GABA-ergic synapse	CACNA1E ADRA1A ADRA2A NRXN3 ITPR1	2.40e-04	164	71	5	GO:0098982
GeneOntologyCellularComponent	presynaptic membrane	CACNA1A CACNA1E ADRA1A ADRA2A NRXN3 NRXN2	3.57e-04	277	71	6	GO:0042734
GeneOntologyCellularComponent	platelet dense tubular network membrane	ITPR1 ITPR2	4.03e-04	9	71	2	GO:0031095
GeneOntologyCellularComponent	platelet dense tubular network	ITPR1 ITPR2	6.13e-04	11	71	2	GO:0031094
GeneOntologyCellularComponent	nuclear membrane	ADRA1B ADRA1A DPY19L3 TEX2 DHCR7 ITPR1	1.19e-03	349	71	6	GO:0031965
GeneOntologyCellularComponent	apical plasma membrane	SLC24A4 SLC15A2 UPK1A ATP6V0A4 F2RL2 TRPV5 SLC5A3	1.31e-03	487	71	7	GO:0016324
GeneOntologyCellularComponent	mitotic spindle midzone	OR2A7 OR2A4	1.32e-03	16	71	2	GO:1990023
GeneOntologyCellularComponent	glutamatergic synapse	CACNA1A CACNA1B ADRA1A ADRA2A NRXN3 NRXN2 IL1RAPL2 RNF19A ELFN1	1.73e-03	817	71	9	GO:0098978
GeneOntologyCellularComponent	T-tubule	CACNA1S ADRA1B ADRA1A	2.47e-03	79	71	3	GO:0030315
GeneOntologyCellularComponent	dopaminergic synapse	ADRA1A ADRA2A	2.51e-03	22	71	2	GO:0098691
GeneOntologyCellularComponent	postsynaptic membrane	CACNA1A CACNA1E SSPN ADRA1A ADRA2A ELFN1	2.53e-03	405	71	6	GO:0045211
GeneOntologyCellularComponent	sarcoplasmic reticulum	CACNA1S ITPR1 ITPR2	3.35e-03	88	71	3	GO:0016529
GeneOntologyCellularComponent	apical part of cell	SLC24A4 SLC15A2 UPK1A ATP6V0A4 F2RL2 TRPV5 SLC5A3	3.92e-03	592	71	7	GO:0045177
GeneOntologyCellularComponent	sarcolemma	CACNA1S SSPN ADRA1B ADRA1A	4.00e-03	190	71	4	GO:0042383
GeneOntologyCellularComponent	endoplasmic reticulum membrane	SGMS2 DPY19L3 SGMS1 TEX2 DHCR7 XK ZDHHC11 CYP39A1 ITPR1 SLC35B1 ITPR2	4.05e-03	1293	71	11	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	SGMS2 DPY19L3 SGMS1 TEX2 DHCR7 XK ZDHHC11 CYP39A1 ITPR1 SLC35B1 ITPR2	4.20e-03	1299	71	11	GO:0098827
GeneOntologyCellularComponent	membrane protein complex	CACNA1A CACNA1B CACNA1E CACNA1S SSPN TPCN2 ATP6V0A4 LRRC8A KCNE5 TRPV6 TRPV5 SLC5A3	4.33e-03	1498	71	12	GO:0098796
GeneOntologyCellularComponent	basolateral plasma membrane	SLC43A2 SLC6A12 ADRA2A ATP6V0A4 SLC5A3	4.65e-03	320	71	5	GO:0016323
GeneOntologyCellularComponent	lysosomal membrane	TPCN2 ATP6V0A4 SLC44A2 LRRC8A SLC30A4 LAPTM5	4.81e-03	462	71	6	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	TPCN2 ATP6V0A4 SLC44A2 LRRC8A SLC30A4 LAPTM5	4.81e-03	462	71	6	GO:0098852
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	SGMS2 DPY19L3 SGMS1 TEX2 DHCR7 XK ZDHHC11 CYP39A1 ITPR1 SLC35B1 ITPR2	4.93e-03	1327	71	11	GO:0042175
GeneOntologyCellularComponent	Flemming body	OR2A7 OR2A4	6.65e-03	36	71	2	GO:0090543
GeneOntologyCellularComponent	sarcoplasm	CACNA1S ITPR1 ITPR2	6.90e-03	114	71	3	GO:0016528
GeneOntologyCellularComponent	basal plasma membrane	SLC43A2 SLC6A12 ADRA2A ATP6V0A4 SLC5A3	7.08e-03	354	71	5	GO:0009925
GeneOntologyCellularComponent	postsynapse	CACNA1A CACNA1E CACNA1S SSPN ADRA1A ADRA2A RNF19A ELFN1 ITPR1	7.36e-03	1018	71	9	GO:0098794
GeneOntologyCellularComponent	vacuolar membrane	TPCN2 ATP6V0A4 SLC44A2 LRRC8A SLC30A4 LAPTM5	7.49e-03	507	71	6	GO:0005774
GeneOntologyCellularComponent	spindle midzone	OR2A7 OR2A4	8.16e-03	40	71	2	GO:0051233
GeneOntologyCellularComponent	somatodendritic compartment	CACNA1A CACNA1B CACNA1E CACNA1S ADRA2A ELFN1 HRH2 TACR3 CX3CR1 ITPR1	8.30e-03	1228	71	10	GO:0036477
GeneOntologyCellularComponent	dendritic tree	CACNA1A CACNA1B CACNA1S ELFN1 HRH2 TACR3 CX3CR1 ITPR1	8.57e-03	860	71	8	GO:0097447
GeneOntologyCellularComponent	basal part of cell	SLC43A2 SLC6A12 ADRA2A ATP6V0A4 SLC5A3	9.25e-03	378	71	5	GO:0045178
GeneOntologyCellularComponent	neuronal cell body membrane	TACR3 CX3CR1	9.39e-03	43	71	2	GO:0032809
GeneOntologyCellularComponent	mitotic spindle pole	OR2A7 OR2A4	9.39e-03	43	71	2	GO:0097431
GeneOntologyCellularComponent	cell body membrane	TACR3 CX3CR1	1.11e-02	47	71	2	GO:0044298
Domain	GPCR_Rhodpsn_7TM	ADRA1B ADRA1A OR2A7 ADRA2A OR2A4 OR10Q1 OR1E1 OR1E2 LGR4 OR5K4 HRH2 TAAR1 GPR171 TACR3 OR51V1 F2RL2 NPFFR1 OR51B2 CX3CR1 OR1J2	2.09e-13	670	69	20	IPR017452
Domain	7tm_1	ADRA1B ADRA1A OR2A7 ADRA2A OR2A4 OR10Q1 OR1E1 OR1E2 LGR4 OR5K4 HRH2 TAAR1 GPR171 TACR3 OR51V1 F2RL2 NPFFR1 OR51B2 CX3CR1 OR1J2	2.54e-13	677	69	20	PF00001
Domain	G_PROTEIN_RECEP_F1_1	ADRA1B ADRA1A OR2A7 ADRA2A OR2A4 OR10Q1 OR1E1 OR1E2 LGR4 OR5K4 HRH2 TAAR1 GPR171 TACR3 OR51V1 F2RL2 NPFFR1 OR51B2 CX3CR1 OR1J2	3.16e-13	685	69	20	PS00237
Domain	G_PROTEIN_RECEP_F1_2	ADRA1B ADRA1A OR2A7 ADRA2A OR2A4 OR10Q1 OR1E1 OR1E2 LGR4 OR5K4 HRH2 TAAR1 GPR171 TACR3 OR51V1 F2RL2 NPFFR1 OR51B2 CX3CR1 OR1J2	3.71e-13	691	69	20	PS50262
Domain	GPCR_Rhodpsn	ADRA1B ADRA1A OR2A7 ADRA2A OR2A4 OR10Q1 OR1E1 OR1E2 LGR4 OR5K4 HRH2 TAAR1 GPR171 TACR3 OR51V1 F2RL2 NPFFR1 OR51B2 CX3CR1 OR1J2	3.81e-13	692	69	20	IPR000276
Domain	Ion_trans_dom	CACNA1A CACNA1B CACNA1E CACNA1S SLC9C1 TPCN2 TRPV6 TRPV5 ITPR1 ITPR2	1.21e-11	114	69	10	IPR005821
Domain	Ion_trans	CACNA1A CACNA1B CACNA1E CACNA1S SLC9C1 TPCN2 TRPV6 TRPV5 ITPR1 ITPR2	1.21e-11	114	69	10	PF00520
Domain	GPHH_dom	CACNA1A CACNA1B CACNA1E CACNA1S	5.92e-09	7	69	4	IPR031649
Domain	VDCC_a1su_IQ	CACNA1A CACNA1B CACNA1E CACNA1S	5.92e-09	7	69	4	IPR014873
Domain	Ca_chan_IQ	CACNA1A CACNA1B CACNA1E CACNA1S	5.92e-09	7	69	4	SM01062
Domain	Ca_chan_IQ	CACNA1A CACNA1B CACNA1E CACNA1S	5.92e-09	7	69	4	PF08763
Domain	GPHH	CACNA1A CACNA1B CACNA1E CACNA1S	5.92e-09	7	69	4	PF16905
Domain	VDCCAlpha1	CACNA1A CACNA1B CACNA1E CACNA1S	3.52e-08	10	69	4	IPR002077
Domain	Channel_four-helix_dom	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2	2.14e-06	57	69	5	IPR027359
Domain	-	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2	2.14e-06	57	69	5	1.20.120.350
Domain	7TM_GPCR_Srsx	ADRA1B ADRA1A ADRA2A HRH2 TAAR1 NPFFR1	3.58e-06	112	69	6	SM01381
Domain	ADR_fam	ADRA1B ADRA1A ADRA2A	5.68e-06	10	69	3	IPR002233
Domain	TRPV5/TRPV6	TRPV6 TRPV5	1.35e-05	2	69	2	IPR008344
Domain	Olfact_rcpt	OR2A7 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2 OR1J2	1.37e-05	393	69	9	IPR000725
Domain	PAP2_C	SGMS2 SGMS1	4.03e-05	3	69	2	PF14360
Domain	InsP3_rcpt-bd	ITPR1 ITPR2	4.03e-05	3	69	2	IPR000493
Domain	Sphingomyelin_synth-like_dom	SGMS2 SGMS1	4.03e-05	3	69	2	IPR025749
Domain	K/Na/Ca-exchanger	SLC24A5 SLC24A4	1.34e-04	5	69	2	IPR004481
Domain	RIH_assoc	ITPR1 ITPR2	2.00e-04	6	69	2	PF08454
Domain	RIH_assoc-dom	ITPR1 ITPR2	2.00e-04	6	69	2	IPR013662
Domain	RYDR_ITPR	ITPR1 ITPR2	2.00e-04	6	69	2	PF01365
Domain	RIH_dom	ITPR1 ITPR2	2.00e-04	6	69	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR1 ITPR2	2.00e-04	6	69	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR1 ITPR2	2.00e-04	6	69	2	IPR015925
Domain	Ins145_P3_rec	ITPR1 ITPR2	2.00e-04	6	69	2	PF08709
Domain	-	ITPR1 ITPR2	2.00e-04	6	69	2	1.25.10.30
Domain	Syndecan	NRXN3 NRXN2	2.79e-04	7	69	2	PF01034
Domain	Syndecan/Neurexin_dom	NRXN3 NRXN2	2.79e-04	7	69	2	IPR027789
Domain	NaCa_Exmemb	SLC24A5 SLC24A4	4.76e-04	9	69	2	IPR004837
Domain	Na_Ca_ex	SLC24A5 SLC24A4	4.76e-04	9	69	2	PF01699
Domain	MIR	ITPR1 ITPR2	5.94e-04	10	69	2	PS50919
Domain	MIR	ITPR1 ITPR2	5.94e-04	10	69	2	PF02815
Domain	MIR	ITPR1 ITPR2	5.94e-04	10	69	2	SM00472
Domain	MIR_motif	ITPR1 ITPR2	5.94e-04	10	69	2	IPR016093
Domain	TRP_channel	TRPV6 TRPV5	7.24e-04	11	69	2	IPR004729
Domain	Neurexin-like	NRXN3 NRXN2	1.19e-03	14	69	2	IPR003585
Domain	4.1m	NRXN3 NRXN2	1.19e-03	14	69	2	SM00294
Domain	P_Acid_Pase_2/haloperoxidase	SGMS2 SGMS1	2.45e-03	20	69	2	IPR000326
Domain	PAP2	SGMS2 SGMS1	2.45e-03	20	69	2	PF01569
Domain	LAM_G_DOMAIN	NRXN3 NRXN2	8.68e-03	38	69	2	PS50025
Domain	Laminin_G_2	NRXN3 NRXN2	9.58e-03	40	69	2	PF02210
Domain	LamG	NRXN3 NRXN2	1.15e-02	44	69	2	SM00282
Domain	MFS_dom	SLC43A2 SLC15A2 UNC93A	1.34e-02	134	69	3	IPR020846
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	CACNA1A CACNA1B CACNA1E CACNA1S ADRA1B ADRA1A HRH2 TACR3 ITPR1 ITPR2	3.49e-09	178	60	10	M2890
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	ADRA1B ADRA1A ADRA2A OR2A4 OR1E1 OR1E2 HRH2 GPR171 F2RL2 NPFFR1 CX3CR1	1.05e-08	260	60	11	M39397
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1A CACNA1B CACNA1E CACNA1S	9.57e-08	11	60	4	M47958
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1A CACNA1B CACNA1E CACNA1S ADRA1B ADRA1A ITPR1 ITPR2	1.87e-07	147	60	8	MM15854
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1A CACNA1B CACNA1E CACNA1S ADRA1B ADRA1A ITPR1 ITPR2	2.30e-07	151	60	8	M39329
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	ADRA1B ADRA1A ADRA2A HRH2 TAAR1	8.88e-07	42	60	5	M5868
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	ADRA1B ADRA1A ADRA2A HRH2 TAAR1	8.88e-07	42	60	5	MM14971
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	ADRA1B ADRA1A ADRA2A HRH2 XK TAAR1 TACR3 F2RL2 NPFFR1 CX3CR1	1.15e-06	330	60	10	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	ADRA1B ADRA1A ADRA2A HRH2 XK TAAR1 TACR3 F2RL2 NPFFR1 CX3CR1	1.25e-06	333	60	10	MM14963
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY	ADRA1B ADRA1A TACR3 ITPR1 ITPR2	2.16e-06	50	60	5	M47951
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1A CACNA1B CACNA1E CACNA1S	2.47e-06	23	60	4	M47666
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1A CACNA1B CACNA1E CACNA1S	3.51e-06	25	60	4	M47948
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	CACNA1A CACNA1E ADRA2A ITPR1 ITPR2	5.84e-06	61	60	5	MM15071
Pathway	REACTOME_ADRENOCEPTORS	ADRA1B ADRA1A ADRA2A	6.05e-06	9	60	3	M27302
Pathway	REACTOME_ADRENOCEPTORS	ADRA1B ADRA1A ADRA2A	6.05e-06	9	60	3	MM15009
Pathway	WP_MONOAMINE_GPCRS	ADRA1B ADRA1A ADRA2A HRH2	8.56e-06	31	60	4	MM15871
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC24A5 SLC43A2 SLC6A12 SLC9C1 TPCN2 SLC24A4 SLC15A2 ATP6V0A4 SLC44A2 LRRC8A TRPV6 TRPV5 SLC5A3	1.02e-05	736	60	13	M27287
Pathway	WP_MONOAMINE_GPCRS	ADRA1B ADRA1A ADRA2A HRH2	1.11e-05	33	60	4	M39585
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1A CACNA1B CACNA1E	1.18e-05	11	60	3	MM14498
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1A CACNA1B CACNA1E	1.18e-05	11	60	3	M26913
Pathway	REACTOME_GPCR_LIGAND_BINDING	ADRA1B ADRA1A ADRA2A HRH2 XK TAAR1 TACR3 F2RL2 NPFFR1 CX3CR1	1.21e-05	430	60	10	MM15160
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	CACNA1A CACNA1E ADRA2A ITPR1 ITPR2	1.33e-05	72	60	5	MM14631
Pathway	REACTOME_SIGNALING_BY_GPCR	ADRA1B ADRA1A ADRA2A HRH2 XK TAAR1 TACR3 F2RL2 NPFFR1 CX3CR1 ITPR1 ITPR2	1.43e-05	646	60	12	MM14962
Pathway	WP_GPCRS_NONODORANT	ADRA1B ADRA1A ADRA2A HRH2 TAAR1 TACR3 F2RL2 CX3CR1	1.58e-05	266	60	8	MM15843
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	ADRA1B ADRA1A ADRA2A HRH2 TAAR1 TACR3 F2RL2 NPFFR1	1.86e-05	272	60	8	M13380
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	CACNA1A CACNA1E ADRA2A ITPR1 ITPR2	1.96e-05	78	60	5	M1921
Pathway	REACTOME_GPCR_LIGAND_BINDING	ADRA1B ADRA1A ADRA2A HRH2 XK TAAR1 TACR3 F2RL2 NPFFR1 CX3CR1	2.29e-05	463	60	10	M507
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC24A5 SLC43A2 SLC6A12 TPCN2 SLC24A4 SLC15A2 ATP6V0A4 SLC44A2 LRRC8A TRPV6 TRPV5 SLC5A3	2.42e-05	681	60	12	MM14985
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	ADRA1B ADRA1A TACR3 F2RL2 NPFFR1 ITPR1 ITPR2	2.91e-05	210	60	7	MM15043
Pathway	REACTOME_SIGNALING_BY_GPCR	ADRA1B ADRA1A ADRA2A HRH2 XK TAAR1 TACR3 F2RL2 NPFFR1 CX3CR1 ITPR1 ITPR2	3.27e-05	702	60	12	M746
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	ADRA1B ADRA1A TACR3 F2RL2 NPFFR1 ITPR1 ITPR2	3.59e-05	217	60	7	M18437
Pathway	WP_GPCRS_ODORANT	OR2A7 OR2A4 OR1E1 OR1E2 LGR4 GPR171	5.28e-05	157	60	6	MM15872
Pathway	WP_GPCRS_OTHER	OR2A7 OR2A4 OR1E1 OR1E2 TACR3	5.36e-05	96	60	5	MM15939
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2A7 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2 OR1J2	6.17e-05	417	60	9	M4072
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC24A5 SLC43A2 SLC6A12 SLC24A4 SLC15A2 SLC44A2 SLC5A3	6.46e-05	238	60	7	MM15076
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC24A5 SLC43A2 SLC6A12 SLC24A4 SLC15A2 SLC44A2 SLC5A3	8.57e-05	249	60	7	M5988
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	CACNA1A CACNA1E ADRA2A ITPR1 ITPR2	9.39e-05	108	60	5	M17034
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC24A5 SLC43A2 SLC6A12 SLC24A4 SLC15A2	9.39e-05	108	60	5	M823
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC24A5 SLC43A2 SLC6A12 SLC24A4 SLC15A2	9.81e-05	109	60	5	MM15074
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	CACNA1S ADRA1B ADRA1A ITPR1 ITPR2	1.26e-04	115	60	5	M9387
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	ADRA1B ADRA1A ADRA2A HRH2 F2RL2 CX3CR1	1.35e-04	186	60	6	MM15994
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR1 ITPR2	1.77e-04	5	60	2	M49000
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2A7 OR2A4 OR10Q1 OR1E1 OR1E2 OR51V1 OR51B2 OR1J2	2.28e-04	389	60	8	M14091
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1B CACNA1S	2.64e-04	6	60	2	M47762
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	2.64e-04	6	60	2	M47960
Pathway	WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY	CACNA1S SSPN ITPR1 ITPR2	2.73e-04	74	60	4	M48080
Pathway	REACTOME_NEURONAL_SYSTEM	CACNA1A CACNA1B CACNA1E SLC6A12 NRXN3 NRXN2 IL1RAPL2	5.27e-04	335	60	7	MM14503
Pathway	KEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	6.29e-04	9	60	2	M47852
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	7.84e-04	10	60	2	M47661
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	9.56e-04	11	60	2	M49033
Pathway	REACTOME_SODIUM_CALCIUM_EXCHANGERS	SLC24A5 SLC24A4	9.56e-04	11	60	2	M27336
Pathway	REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION	ITPR1 ITPR2	9.56e-04	11	60	2	M27466
Pathway	KEGG_TYPE_II_DIABETES_MELLITUS	CACNA1A CACNA1B CACNA1E	1.04e-03	47	60	3	M19708
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	SLC9C1 TPCN2 TRPV6 TRPV5	1.07e-03	106	60	4	M27200
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	SLC9C1 TPCN2 ATP6V0A4 TRPV6 TRPV5	1.07e-03	183	60	5	M997
Pathway	REACTOME_SODIUM_CALCIUM_EXCHANGERS	SLC24A5 SLC24A4	1.35e-03	13	60	2	MM15078
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.35e-03	13	60	2	M47696
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.35e-03	13	60	2	M47751
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	1.35e-03	13	60	2	M47656
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2	1.35e-03	13	60	2	MM14553
Pathway	REACTOME_SENSORY_PERCEPTION	OR2A7 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2 OR1J2	1.38e-03	636	60	9	M41834
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	XK TACR3 F2RL2 NPFFR1 CX3CR1	1.48e-03	197	60	5	M12289
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	XK TACR3 F2RL2 NPFFR1 CX3CR1	1.48e-03	197	60	5	MM14970
Pathway	REACTOME_NEURONAL_SYSTEM	CACNA1A CACNA1B CACNA1E SLC6A12 NRXN3 NRXN2 IL1RAPL2	1.73e-03	411	60	7	M735
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2	2.06e-03	16	60	2	M26945
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	NRXN3 NRXN2 IL1RAPL2	2.89e-03	67	60	3	MM15327
Pathway	REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION	ITPR1 ITPR2	2.91e-03	19	60	2	M27423
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	2.91e-03	19	60	2	M47760
Pathway	KEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	2.91e-03	19	60	2	M47733
Pathway	KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	3.22e-03	20	60	2	M47688
Pathway	KEGG_LONG_TERM_DEPRESSION	CACNA1A ITPR1 ITPR2	3.28e-03	70	60	3	M8232
Pathway	WP_METABOLISM_OF_SPHINGOLIPIDS_IN_ER_AND_GOLGI_APPARATUS	SGMS2 SGMS1	3.55e-03	21	60	2	M39459
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	3.55e-03	21	60	2	M47689
Pathway	WP_ALZHEIMERS_DISEASE	CACNA1S ITPR1 ITPR2	3.83e-03	74	60	3	MM15962
Pathway	WP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA	CACNA1A ITPR1	3.90e-03	22	60	2	M39795
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	3.90e-03	22	60	2	M47690
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	3.90e-03	22	60	2	M47675
Pathway	WP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES	SGMS2 SGMS1	3.90e-03	22	60	2	M45544
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC6A12 SLC44A2 SLC5A3	4.13e-03	76	60	3	MM15072
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	4.26e-03	23	60	2	M47676
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	SGMS2 SGMS1	5.02e-03	25	60	2	MM15931
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	ITPR1 ITPR2	5.02e-03	25	60	2	MM14511
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	SGMS2 SGMS1	5.42e-03	26	60	2	M39784
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	SGMS2 SGMS1	5.42e-03	26	60	2	MM15892
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC6A12 SLC44A2 SLC5A3	5.47e-03	84	60	3	M27334
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	ITPR1 ITPR2	5.84e-03	27	60	2	M12123
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	SGMS2 SGMS1	5.84e-03	27	60	2	M39863
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR1 ITPR2	5.84e-03	27	60	2	MM15053
Pathway	WP_HIPPOCAMPAL_SYNAPTOGENESIS_AND_NEUROGENESIS	NRXN3 NRXN2	5.84e-03	27	60	2	M45550
Pathway	REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS	SGMS2 SGMS1	5.84e-03	27	60	2	MM14646
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	NRXN3 NRXN2 IL1RAPL2	6.03e-03	87	60	3	M27617
Pathway	REACTOME_TRP_CHANNELS	TRPV6 TRPV5	6.27e-03	28	60	2	MM14943
Pathway	REACTOME_TRP_CHANNELS	TRPV6 TRPV5	6.27e-03	28	60	2	M27241
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR1 ITPR2	6.27e-03	28	60	2	M924
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TPCN2 ATP6V0A4 TRPV6 TRPV5	6.65e-03	176	60	4	MM15718
Pathway	WP_SPHINGOLIPID_PATHWAY	SGMS2 SGMS1	7.18e-03	30	60	2	M39501
Pathway	WP_VITAMIN_D_RECEPTOR_PATHWAY	ADRA1B LRRC8A TRPV6 TRPV5	7.90e-03	185	60	4	M39718
Pathway	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE	SLC43A2 SLC6A12	8.14e-03	32	60	2	MM14957
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	NRXN3 NRXN2	8.14e-03	32	60	2	MM15326
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	ITPR1 ITPR2	8.14e-03	32	60	2	MM14983
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	CACNA1A CACNA1B CACNA1E NRXN3 NRXN2	1.98e-13	6	72	5	12827191
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1A CACNA1B CACNA1E TRPV6 TRPV5 ITPR1 ITPR2	1.45e-12	38	72	7	30786075
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1A CACNA1B CACNA1E CACNA1S	2.11e-09	9	72	4	16382099
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1A CACNA1B CACNA1E	8.51e-09	3	72	3	38996073
Pubmed	Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.	CACNA1A CACNA1B CACNA1E	8.51e-09	3	72	3	24523520
Pubmed	Evolution of odorant receptors expressed in mammalian testes.	OR2A7 OR2A4 OR1E1 OR1E2	1.19e-08	13	72	4	11014824
Pubmed	Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.	OR2A7 OR2A4 OR1E1 OR1E2	1.66e-08	14	72	4	7528109
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1A CACNA1B CACNA1E CACNA1S	2.26e-08	15	72	4	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1A CACNA1B CACNA1E CACNA1S	2.26e-08	15	72	4	24453333
Pubmed	Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.	CACNA1A CACNA1B CACNA1E	3.40e-08	4	72	3	32616470
Pubmed	Cerebellar granule cell signaling is indispensable for normal motor performance.	CACNA1A CACNA1B CACNA1E	3.40e-08	4	72	3	37141091
Pubmed	Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.	CACNA1A CACNA1B CACNA1E	8.48e-08	5	72	3	8825650
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1A CACNA1B CACNA1E	8.48e-08	5	72	3	15451373
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1A CACNA1B CACNA1E	8.48e-08	5	72	3	11296258
Pubmed	Expression of adrenergic receptors in mouse preimplantation embryos and ovulated oocytes.	ADRA1B ADRA1A ADRA2A	1.69e-07	6	72	3	17636168
Pubmed	An action potential initiation mechanism in distal axons for the control of dopamine release.	CACNA1A CACNA1B CACNA1E	1.69e-07	6	72	3	35324301
Pubmed	Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.	CACNA1A CACNA1B CACNA1E	1.69e-07	6	72	3	9238069
Pubmed	Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.	CACNA1A CACNA1S NRXN3 NRXN2 TACR3	2.89e-07	67	72	5	16987237
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1A CACNA1B CACNA1E	2.96e-07	7	72	3	35176221
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1B CACNA1E CACNA1S	4.73e-07	8	72	3	28330839
Pubmed	Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.	ADRA1B ADRA1A ADRA2A	4.73e-07	8	72	3	9139936
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2A7 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2	5.34e-07	340	72	8	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2A7 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2	5.34e-07	340	72	8	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2A7 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2	5.70e-07	343	72	8	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2A7 OR2A4 OR10Q1 OR1E1 OR1E2 OR5K4 OR51V1 OR51B2	6.09e-07	346	72	8	14611657
Pubmed	Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo.	ADRA1B ADRA1A ADRA2A	7.08e-07	9	72	3	21209093
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	SLC43A2 SSPN ADRA1A TPCN2 NRXN3 SLC44A2 TAAR1 SERINC5 ZDHHC11 SLC35B1	1.72e-06	697	72	10	28298427
Pubmed	Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.	ADRA2A TRPV6 TRPV5	2.40e-06	13	72	3	22266179
Pubmed	Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus.	SGMS2 SGMS1	4.23e-06	2	72	2	27892528
Pubmed	An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes.	ADRA1B ADRA1A	4.23e-06	2	72	2	17283256
Pubmed	ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.	ZDHHC11B ZDHHC11	4.23e-06	2	72	2	28331227
Pubmed	Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload.	ADRA1B ADRA1A	4.23e-06	2	72	2	16585965
Pubmed	Evaluation of the genes for the adrenergic receptors alpha 2A and alpha 1C and Gilles de la Tourette Syndrome.	ADRA1A ADRA2A	4.23e-06	2	72	2	12707939
Pubmed	Chlamydia trachomatis-infected human cells convert ceramide to sphingomyelin without sphingomyelin synthases 1 and 2.	SGMS2 SGMS1	4.23e-06	2	72	2	31596951
Pubmed	Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta.	TRPV6 TRPV5	4.23e-06	2	72	2	20178461
Pubmed	The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.	TRPV6 TRPV5	4.23e-06	2	72	2	22354706
Pubmed	Oligomerization of the alpha 1a- and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization.	ADRA1B ADRA1A	4.23e-06	2	72	2	12888550
Pubmed	Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane.	TRPV6 TRPV5	4.23e-06	2	72	2	16564089
Pubmed	Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells.	TRPV6 TRPV5	4.23e-06	2	72	2	19295174
Pubmed	Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity.	TRPV6 TRPV5	4.23e-06	2	72	2	23968883
Pubmed	Blocking the R-type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance.	CACNA1B CACNA1E	4.23e-06	2	72	2	15610184
Pubmed	Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.	CACNA1A CACNA1B	4.23e-06	2	72	2	23426690
Pubmed	Expression of calcium channels along the differentiation of cultured trophoblast cells from human term placenta.	TRPV6 TRPV5	4.23e-06	2	72	2	12390878
Pubmed	Alpha-adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in Black adolescents and young adults.	ADRA1A ADRA2A	4.23e-06	2	72	2	22091949
Pubmed	Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.	TRPV6 TRPV5	4.23e-06	2	72	2	12574114
Pubmed	Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.	CACNA1A CACNA1E	4.23e-06	2	72	2	16381801
Pubmed	Carboxyl-terminal Tail-mediated Homodimerizations of Sphingomyelin Synthases Are Responsible for Efficient Export from the Endoplasmic Reticulum.	SGMS2 SGMS1	4.23e-06	2	72	2	27927984
Pubmed	The domain responsible for sphingomyelin synthase (SMS) activity.	SGMS2 SGMS1	4.23e-06	2	72	2	18694848
Pubmed	Effect of liver total sphingomyelin synthase deficiency on plasma lipid metabolism.	SGMS2 SGMS1	4.23e-06	2	72	2	33545384
Pubmed	Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.	TRPV6 TRPV5	4.23e-06	2	72	2	11549322
Pubmed	[TRPV5 and TRPV6 calcium channels in human T cells].	TRPV6 TRPV5	4.23e-06	2	72	2	19140341
Pubmed	TRPV5 and TRPV6 are expressed in placenta and bone tissues during pregnancy in mice.	TRPV6 TRPV5	4.23e-06	2	72	2	30916584
Pubmed	Sphingomyelin synthases regulate production of diacylglycerol at the Golgi.	SGMS2 SGMS1	4.23e-06	2	72	2	18370930
Pubmed	Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice.	SGMS2 SGMS1	4.23e-06	2	72	2	16508036
Pubmed	alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse.	ADRA1B ADRA1A	4.23e-06	2	72	2	19540213
Pubmed	Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.	TRPV6 TRPV5	4.23e-06	2	72	2	16565876
Pubmed	Deficiency of sphingomyelin synthase 1 but not sphingomyelin synthase 2 reduces bone formation due to impaired osteoblast differentiation.	SGMS2 SGMS1	4.23e-06	2	72	2	31847800
Pubmed	Exploring an interaction of adenosine A2A receptor variability with coffee and tea intake in Parkinson's disease.	ADRA1A ADRA2A	4.23e-06	2	72	2	16823803
Pubmed	An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.	ITPR1 ITPR2	4.23e-06	2	72	2	18708078
Pubmed	The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse.	ADRA1B ADRA1A	4.23e-06	2	72	2	12782680
Pubmed	Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.	ITPR1 ITPR2	4.23e-06	2	72	2	15201137
Pubmed	Differential localization of sphingomyelin synthase isoforms in neurons regulates sphingomyelin cluster formation.	SGMS2 SGMS1	4.23e-06	2	72	2	22209789
Pubmed	Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy.	SGMS2 SGMS1	4.23e-06	2	72	2	22106271
Pubmed	Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes.	ADRA1B ADRA1A	4.23e-06	2	72	2	22120526
Pubmed	Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.	TRPV6 TRPV5	4.23e-06	2	72	2	16705151
Pubmed	Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.	ITPR1 ITPR2	4.23e-06	2	72	2	23582047
Pubmed	Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.	CACNA1A CACNA1B	4.23e-06	2	72	2	23376566
Pubmed	SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis.	SGMS2 SGMS1	4.23e-06	2	72	2	17982138
Pubmed	Hypokalaemic periodic paralysis due to the CACNA1S R1239H mutation in a large African family.	CACNA1A CACNA1S	4.23e-06	2	72	2	17418573
Pubmed	2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity.	SGMS2 SGMS1	4.23e-06	2	72	2	30305392
Pubmed	Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in retinal pigment epithelium.	TRPV6 TRPV5	4.23e-06	2	72	2	20405023
Pubmed	Allelic variants of the alpha1a adrenoceptor and the promoter region of the alpha2a adrenoceptor and temperament factors.	ADRA1A ADRA2A	4.23e-06	2	72	2	11425010
Pubmed	A Functional Study of Mutations in K+-dependent Na+-Ca2+ Exchangers Associated with Amelogenesis Imperfecta and Non-syndromic Oculocutaneous Albinism.	SLC24A5 SLC24A4	4.23e-06	2	72	2	27129268
Pubmed	A single amino acid mutation results in a rapid inactivation of epithelial calcium channels.	TRPV6 TRPV5	4.23e-06	2	72	2	11846401
Pubmed	First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation.	TRPV6 TRPV5	4.23e-06	2	72	2	25164318
Pubmed	Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells.	SGMS2 SGMS1	4.23e-06	2	72	2	17449912
Pubmed	[Distribution and significance of α1-adrenoceptor subtypes in patients with chronic prostatitis in prostate, bladder detrusor and posterior urethral tissue].	ADRA1B ADRA1A	4.23e-06	2	72	2	21223784
Pubmed	Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization.	SGMS2 SGMS1	4.23e-06	2	72	2	17616479
Pubmed	{alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium.	ADRA1B ADRA1A	4.23e-06	2	72	2	19919991
Pubmed	Expression and prognostic roles of TRPV5 and TRPV6 in non-small cell lung cancer after curative resection.	TRPV6 TRPV5	4.23e-06	2	72	2	24761864
Pubmed	CaV 2.1 α1 subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.	CACNA1A CACNA1B	4.23e-06	2	72	2	38155373
Pubmed	Effects of ablation of N- and R-type Ca(2+) channels on pain transmission.	CACNA1B CACNA1E	4.23e-06	2	72	2	12074836
Pubmed	Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin.	TRPV6 TRPV5	4.23e-06	2	72	2	15123711
Pubmed	ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain.	LRRC8A CX3CR1	4.23e-06	2	72	2	36989353
Pubmed	Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.	TRPV6 TRPV5	4.23e-06	2	72	2	12077127
Pubmed	Sphingomyelin synthases regulate protein trafficking and secretion.	SGMS2 SGMS1	4.23e-06	2	72	2	21980337
Pubmed	An inositolphosphorylceramide synthase is involved in regulation of plant programmed cell death associated with defense in Arabidopsis.	SGMS2 SGMS1	4.23e-06	2	72	2	19001565
Pubmed	Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes.	ADRA1B ADRA1A	4.23e-06	2	72	2	18802028
Pubmed	Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.	ITPR1 ITPR2	4.23e-06	2	72	2	19120126
Pubmed	Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2.	TRPV6 TRPV5	4.23e-06	2	72	2	11719848
Pubmed	Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.	TRPV6 TRPV5	4.23e-06	2	72	2	17233615
Pubmed	Differences in the signaling pathways of α(1A)- and α(1B)-adrenoceptors are related to different endosomal targeting.	ADRA1B ADRA1A	4.23e-06	2	72	2	23717684
Pubmed	[The functional characteristics oF TRPV5 and TRPV6 channels in normal and transformed human blood lymphocytes].	TRPV6 TRPV5	4.23e-06	2	72	2	24592736
Pubmed	Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.	CACNA1A CACNA1B	4.23e-06	2	72	2	15050706
Pubmed	Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice.	SGMS2 SGMS1	4.23e-06	2	72	2	22641779
Pubmed	Abnormal myocardial contraction in alpha(1A)- and alpha(1B)-adrenoceptor double-knockout mice.	ADRA1B ADRA1A	4.23e-06	2	72	2	14519431
Pubmed	Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization.	ZDHHC11B ZDHHC11	4.23e-06	2	72	2	35384384
Pubmed	Sphingomyelin synthases 1 and 2 exhibit phosphatidylcholine phospholipase C activity.	SGMS2 SGMS1	4.23e-06	2	72	2	34774525
Pubmed	The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.	ADRA1B ADRA1A ADRA2A	4.67e-06	16	72	3	15824464
Pubmed	Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.	NRXN3 NRXN2	1.27e-05	3	72	2	34133920
Cytoband	17p13.3	SLC43A2 OR1E1 OR1E2	3.54e-04	88	71	3	17p13.3
Cytoband	3q13.2	SLC9C1 SIDT1	1.07e-03	31	71	2	3q13.2
Cytoband	5p15.33	ZDHHC11B ZDHHC11	1.14e-03	32	71	2	5p15.33
Cytoband	15q21.1	SLC24A5 SLC30A4	1.52e-03	37	71	2	15q21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7q34	ATP6V0A4 TRPV6 TRPV5	3.01e-03	185	71	3	chr7q34
Cytoband	9q34.11	LRRC8A OR1J2	3.09e-03	53	71	2	9q34.11
Cytoband	7q35	OR2A7 TRPV5	3.32e-03	55	71	2	7q35
Cytoband	4q25	SGMS2 TACR3	4.89e-03	67	71	2	4q25
Cytoband	Ensembl 112 genes in cytogenetic band chr3q13	SLC9C1 SLC15A2 SIDT1	4.94e-03	221	71	3	chr3q13
GeneFamily	Solute carriers	SLC24A5 SLC43A2 SLC6A12 SLC9C1 SLC24A4 SLC15A2 SLC44A2 SLC30A4 SLC35B1 SLC5A3	2.69e-07	395	55	10	752
GeneFamily	Calcium voltage-gated channel subunits	CACNA1A CACNA1B CACNA1E CACNA1S	1.09e-06	26	55	4	253
GeneFamily	Adrenoceptors	ADRA1B ADRA1A ADRA2A	2.21e-06	9	55	3	169
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR2	2.72e-05	3	55	2	297
GeneFamily	Olfactory receptors, family 1	OR1E1 OR1E2 OR1J2	2.43e-04	40	55	3	147
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC11B ZDHHC11	2.40e-03	24	55	2	76
GeneFamily	Transient receptor potential cation channels	TRPV6 TRPV5	3.26e-03	28	55	2	249
GeneFamily	Olfactory receptors, family 51	OR51V1 OR51B2	7.92e-03	44	55	2	164
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ADRA1B ADRA1A NRXN3 TMEM132E ELFN1 NPFFR1	3.27e-07	169	72	6	c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCell	facs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E NRXN2 TEX2 SLC44A2 HS3ST3A1 ITPR1	4.15e-07	176	72	6	74f851a398c7562dd713bc0d8d488c0037243112
ToppCell	facs-Marrow-T_cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E NRXN2 TEX2 SLC44A2 HS3ST3A1 ITPR1	4.15e-07	176	72	6	31b5459a978d5cdde0af03a77401e0464d8c95ba
ToppCell	facs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E NRXN2 TEX2 SLC44A2 SERINC5 ITPR1	4.73e-07	180	72	6	bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCell	facs-Marrow-B-cells-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E NRXN2 TEX2 SLC44A2 SERINC5 ITPR1	4.73e-07	180	72	6	839defb40f7cfb2711e9025194de636533f51bcd
ToppCell	facs-Marrow-B-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E NRXN2 TEX2 SLC44A2 SERINC5 ITPR1	4.73e-07	180	72	6	82965ed1b72a1873c24dd4553d39681596057316
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPCN2 DHCR7 TRPV6 ZDHHC11 CYP39A1	3.33e-06	141	72	5	9a0f4bee2893da1b13ab89494e6159821d53538b
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADRA2A GPR171 F2RL2 CX3CR1 LAPTM5	4.22e-06	148	72	5	3f48f5ba0a0928ddf6da7a1be1976933921f42ad
ToppCell	Cerebellum-Macroglia-ASTROCYTE\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ADRA1A SLC15A2 KCNE5 MMD2 MSTN	4.65e-06	151	72	5	71841d2001200d1595c85c2b007ee20791a72927
ToppCell	Cerebellum-Macroglia-ASTROCYTE-Gja1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ADRA1A SLC15A2 KCNE5 MMD2 MSTN	4.65e-06	151	72	5	60aced0c1cc6b509b73308d03d58a3c44d712ef4
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Shox2_(peripeduncular_nucleus_&_posterior_intralaminar_thalamic_nucleus_(PP_&_PIL))\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	UPK1A TRPV6 TAAR1 F2RL2	4.82e-06	69	72	4	72031d97bf3a3f3e8fe2ad1130c766e39b3b4c46
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Shox2_(peripeduncular_nucleus_&_posterior_intralaminar_thalamic_nucleus_(PP_&_PIL))-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	UPK1A TRPV6 TAAR1 F2RL2	4.82e-06	69	72	4	20bda1222efe784b025c6b311a7813b3b562ec71
ToppCell	Striatum-Neuronal-Inhibitory\|Striatum / BrainAtlas - Mouse McCarroll V32	ADRA1B ADRA1A IL1RAPL2 ELFN1 SIDT1	5.62e-06	157	72	5	c41ff3fe9de7187575114febfe9bd8733366fb8a
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UPK1A HRH2 GPR171 ZDHHC11 F2RL2	5.98e-06	159	72	5	709b57f992a29878cc899d760d144d36cb5cb280
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-24m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E CACNA1S GPR171 ZDHHC11 LAPTM5	6.17e-06	160	72	5	6bafbe2b4b98bc088406a516d079093f89d9c344
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC43A2 NRXN3 ATP6V0A4 ITPR1 ITPR2	9.53e-06	175	72	5	77c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ELFN1 ATP6V0A4 LGR4 TRPV6 TRPV5	1.01e-05	177	72	5	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	droplet-Marrow-nan-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E NRXN2 TEX2 GPR171 ITPR1	1.06e-05	179	72	5	dcaf2191134a586d50ebaf67dcf5b815b54a722b
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E NRXN2 TEX2 GPR171 ITPR1	1.06e-05	179	72	5	87a69f9f83b8f0c028a4874acb238f2e079bf51f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ATP6V0A4 HRH2 TRPV6 TRPV5 ITPR1	1.06e-05	179	72	5	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E NRXN2 TEX2 GPR171 ITPR1	1.09e-05	180	72	5	df60970520fba2ac0639faa54096766d07418ca4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC43A2 NRXN3 ATP6V0A4 LGR4 ITPR2	1.12e-05	181	72	5	30729f0364f719c044712a51453e22dc2c1a232b
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA1B NRXN2 TEX2 SLC44A2 GPR171	1.12e-05	181	72	5	fb64da1dde37fe6ba7de2586cd58848ac1974f24
ToppCell	Hippocampus-Neuronal-Inhibitory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ADRA1B NRXN3 TMEM132E ELFN1 NPFFR1	1.15e-05	182	72	5	b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 TRPV6 TRPV5 ITPR1 SLC5A3	1.18e-05	183	72	5	2f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN2 TEX2 DHCR7 SLC44A2 GPR171	1.25e-05	185	72	5	65dcb0a7ee64990a34a87c167b44497107f035ee
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A CACNA1E NRXN3 NRXN2 SIDT1	1.53e-05	193	72	5	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A CACNA1E NRXN3 NRXN2 SIDT1	1.53e-05	193	72	5	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A CACNA1E NRXN3 NRXN2 SIDT1	1.53e-05	193	72	5	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	Fetal_29-31_weeks-Immune-monocyte-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC43A2 SLC24A4 HRH2 CX3CR1 LAPTM5	1.69e-05	197	72	5	8b9a88fb671d5c2b25d291c851e2b8a478f2610c
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Dendritic_cell\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SLC24A4 TMEM132E HRH2 NPFFR1 LAPTM5	1.69e-05	197	72	5	7e15ed71881105dee5c7ffc052063ecc8ac0b36e
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CACNA1A ADRA1A NRXN3 SLC24A4 ELFN1	1.81e-05	200	72	5	f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Monocytic-Monocyte_CD16\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLC43A2 SLC24A4 HRH2 CX3CR1 LAPTM5	1.81e-05	200	72	5	83d9aa5b46ae7a71a258b2e44b3251f95bc9a1b7
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-CALB1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CACNA1A ADRA1A NRXN3 SLC24A4 ELFN1	1.81e-05	200	72	5	70a06fd7fb8de2c8ec3e3182e4476ced049daeae
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Monocytic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLC43A2 SLC24A4 HRH2 CX3CR1 LAPTM5	1.81e-05	200	72	5	d237cf947d6768b022d18211e14af4adb4990708
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-CALB1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CACNA1A ADRA1A NRXN3 SLC24A4 ELFN1	1.81e-05	200	72	5	1639982d9d994918f7912d12d9d7cfcbc9da4145
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Monocytic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLC43A2 SLC24A4 HRH2 CX3CR1 LAPTM5	1.81e-05	200	72	5	0855ebb10b925664aa5cf813d97e97683c46180d
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pmch_(Lateral_hypothalamus_(LH))\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ADRA2A TPCN2 TACR3 NPFFR1	2.85e-05	108	72	4	ba83418023d9d296b0edd4c4e1832a33bc9b3b69
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pmch_(Lateral_hypothalamus_(LH))--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ADRA2A TPCN2 TACR3 NPFFR1	2.85e-05	108	72	4	a93a427ab16628c86db3bb17bfecf801f56ce270
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pmch_(Lateral_hypothalamus_(LH))-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ADRA2A TPCN2 TACR3 NPFFR1	2.85e-05	108	72	4	673da75b24218557d01ee461a13c426040da74b9
ToppCell	COVID-19-kidney-Technical/muscle_(EC)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1A CACNA1B MMD2 OR51V1	5.54e-05	128	72	4	91072ca56bce2c552a95edd67e17f43d8cc1de95
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZDHHC11B ATP6V0A4 TRPV5 ITPR1	7.21e-05	137	72	4	85b3a98039c1f68addad0334aa5b2584f6045aaa
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ADRA1B ELFN1 HRH2 NPFFR1	7.63e-05	139	72	4	408bc31aa5e1c2b379f79198fe8b5411f8d7bd08
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B SLC9C1 UNC93A TACR3	8.98e-05	145	72	4	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRA1A SLC24A4 HS3ST3A1 ZDHHC11	9.72e-05	148	72	4	dfd3f2c4b884ea9e23831a242a89ac985b409640
ToppCell	facs-Lung-3m-Hematologic-Lymphocytic_NK_ILC\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SIDT1 GPR171 TRPV5 LAPTM5	1.02e-04	150	72	4	1f83e3be3f94aefe991a3ccd292c2d11ddef858e
ToppCell	facs-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SIDT1 GPR171 TRPV5 LAPTM5	1.02e-04	150	72	4	cd666db614bc1b43d71e8eb7bf38cae4d580be80
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC43A2 NRXN3 ATP6V0A4 TRPV5	1.02e-04	150	72	4	87968ce885a4959616f0321f58517fe8029ba1b1
ToppCell	facs-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SIDT1 GPR171 TRPV5 LAPTM5	1.02e-04	150	72	4	f6ed3e7b36014d1e429b255b0027d89865e1ac07
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC43A2 NRXN3 ATP6V0A4 ITPR2	1.22e-04	157	72	4	c17c5c01fcb65c453690c265ec4f300ecdfefd34
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-cortical_neurons_1\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	TMPPE ZDHHC11B DPY19L3 TMEM132E	1.25e-04	158	72	4	1f94622186d8329357fa06785e03eeacf29ab1ce
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ADRA1B TMEM132E HRH2 NPFFR1	1.28e-04	159	72	4	7f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC43A2 GPR171 CX3CR1 LAPTM5	1.31e-04	160	72	4	18954241e11309ecb0f3ca87897eadcb20dc8eca
ToppCell	droplet-Fat-Scat-21m-Lymphocytic-B_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E CACNA1S UPK1A GPR171	1.34e-04	161	72	4	e52735f955f0a53da5cbe5a2d77a00484e5109b3
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A12 LGR4 TRPV5 ITPR1	1.38e-04	162	72	4	36ddebe3bb172c992739353b7b049b2dde98b559
ToppCell	TCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma-3\|TCGA-Uterus / Sample_Type by Project: Shred V9	ADRA2A RNF19A TAAR1 SERINC5	1.41e-04	163	72	4	d64dd39b077105c73e570ccef70f0e74a2c586ac
ToppCell	control-Epithelial-Ionocyte\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SLC43A2 DHCR7 ATP6V0A4 ITPR2	1.48e-04	165	72	4	5cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCell	droplet-Lung-LUNG-1m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEX2 GPR171 SERINC5 ITPR1	1.51e-04	166	72	4	6e6075d0c913e2516083f6dcab21d5878bcef7a4
ToppCell	droplet-Lung-1m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TEX2 GPR171 SERINC5 ITPR1	1.51e-04	166	72	4	1ca888ae8168707493f19ee52a89d7c70e6cb51d
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEX2 GPR171 SERINC5 ITPR1	1.51e-04	166	72	4	4fbe44e0aea197893614cd55f83119aa0f73ee53
ToppCell	droplet-Lung-1m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TEX2 GPR171 SERINC5 ITPR1	1.51e-04	166	72	4	4cba4ca1aa2321b9ef7cd230932b890d2434a252
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A CACNA1B CACNA1E MMD2	1.55e-04	167	72	4	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	facs-Heart-LA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E CACNA1S GPR171 LAPTM5	1.55e-04	167	72	4	8ce8d93c79ac6a3f52252b4cec53378c362bfe0a
ToppCell	facs-Heart-LA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E CACNA1S GPR171 LAPTM5	1.55e-04	167	72	4	8340f7075d00dccb304cfd4c9b5711ca6dbf7cce
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A SLC43A2 TMEM132E ATP6V0A4	1.55e-04	167	72	4	f5bffa77061baec0ba87bd688a047595f32534db
ToppCell	droplet-Lung-LUNG-30m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E NRXN2 TEX2 GPR171	1.58e-04	168	72	4	e156297a7515e785a9e79a9676700bd3a9d92b98
ToppCell	control-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SLC43A2 DHCR7 ATP6V0A4 ITPR2	1.58e-04	168	72	4	327b02f19f4a8607c033203824fdc60a1254331f
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E NRXN2 TEX2 GPR171	1.58e-04	168	72	4	32e0bc0873baa13027241063283ef26d2aab56f5
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HRH2 GPR171 CX3CR1 ITPR2	1.58e-04	168	72	4	19d2c763b50e7168dfa7449fc407489b055526c2
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-mature_NK_T_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HRH2 GPR171 CX3CR1 ITPR2	1.58e-04	168	72	4	fa198bd53b2d640d9a8684783bf5ca23314caae2
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1B HRH2 CX3CR1 LAPTM5	1.62e-04	169	72	4	c3d410a5e98000ba872141b62e17ef4ed3d1a8eb
ToppCell	droplet-Lung-nan-18m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E NRXN2 TEX2 GPR171	1.66e-04	170	72	4	749144a1a869a6bf9acdd227184319083367dc3f
ToppCell	droplet-Lung-nan-18m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E NRXN2 TEX2 GPR171	1.66e-04	170	72	4	25d60a62e8f99c31ab64fe6a0c07ccca3df1a7ee
ToppCell	droplet-Pancreas-Endocrine-21m-Hematologic-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S SLC6A12 UPK1A LAPTM5	1.66e-04	170	72	4	6086d658a52a1961a1e293cbc3703ae8d309cd11
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-mature_NK_T_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UPK1A GPR171 F2RL2 CX3CR1	1.69e-04	171	72	4	a0462781d22c391b3c6c8a72586c385ac089ca5d
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UPK1A GPR171 F2RL2 CX3CR1	1.69e-04	171	72	4	85b655dc8a3cbf0e8097e951116490e326a795ac
ToppCell	droplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E NRXN2 TEX2 GPR171	1.73e-04	172	72	4	422d311bba2dd5d8bece4e96ee8c86e78086b62d
ToppCell	droplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E NRXN2 TEX2 GPR171	1.73e-04	172	72	4	1abb6fbb28c8aff384540493d0f70eeacaa751f4
ToppCell	droplet-Lung-nan-3m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TEX2 DHCR7 GPR171	1.77e-04	173	72	4	1b9b4e165121b08ef15a93fca6bea875cae69f19
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E NRXN2 TEX2 GPR171	1.77e-04	173	72	4	4f0c065e876197ad8cae7856669f09e37ecafa3f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC43A2 NRXN3 ATP6V0A4 ITPR2	1.77e-04	173	72	4	0bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC24A4 HRH2 CX3CR1 LAPTM5	1.77e-04	173	72	4	0a0127bcb1d7b2b6125faef576dd843055095528
ToppCell	droplet-Lung-nan-3m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TEX2 DHCR7 GPR171	1.77e-04	173	72	4	c25f24d7b672c9686d31ebc8d263042282f520fd
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1E NRXN2 TEX2 GPR171	1.77e-04	173	72	4	9bbea566964281f47bf75d665b7d69ba8326e207
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC43A2 NRXN3 ATP6V0A4 ITPR2	1.81e-04	174	72	4	5f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCell	COVID-19-kidney-REN+Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1A NRXN2 HRH2 HS3ST3A1	1.81e-04	174	72	4	8393f0b43c767839c1630bcb952d62b42efc788d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC24A5 CACNA1A HS3ST3A1 MSTN	1.85e-04	175	72	4	12f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADRA1A NRXN3 IL1RAPL2 HRH2	1.85e-04	175	72	4	316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADRA1A NRXN3 IL1RAPL2 HRH2	1.85e-04	175	72	4	a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SGMS2 ELFN1 ATP6V0A4 LGR4	1.85e-04	175	72	4	085cceb1fc2c4ae2f27e85cea5702defecc2cf44
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEX2 SLC44A2 GPR171 HS3ST3A1	1.89e-04	176	72	4	d4075796c38b775fe721abb47426e662a0d415e3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC43A2 NRXN3 ATP6V0A4 ITPR2	1.89e-04	176	72	4	c2c4306476989bc2fb30dab00250ef7915842f13
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E CACNA1S XK SERINC5	1.89e-04	176	72	4	606704098bfdf8bfef740a3544a372fae1e75969
ToppCell	facs-Heart-RV-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A12 MMD2 F2RL2 TMEM121	1.89e-04	176	72	4	3e7647364c13beade9ca278c7ce8e89546e0b060
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC15A2 LGR4 KCNE5 MMD2	1.89e-04	176	72	4	ac3dc44755280e36c0947b6de3cd639dc17de8b6
ToppCell	facs-Heart-RV-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A12 MMD2 F2RL2 TMEM121	1.89e-04	176	72	4	a55572470de6af6cbf29ed4f785fdca62d24cd23
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E CACNA1S XK SERINC5	1.89e-04	176	72	4	acb9e29773030f6452a069f8f7e53eab68ab7bd3
ToppCell	facs-Skin-Anagen-3m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HRH2 F2RL2 CX3CR1 LAPTM5	1.93e-04	177	72	4	7853430fb0d1a18d835e8956777e0616c5d7d412
ToppCell	facs-Skin-nan-18m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SIDT1 GPR171 F2RL2 LAPTM5	1.93e-04	177	72	4	17065d37fd41f04f67282bee00365daa185e8355
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HRH2 F2RL2 TMEM121 LAPTM5	1.93e-04	177	72	4	36da06ca9577cdb7c7b5114e604f6546b9765c08
Computational	Genes in the cancer module 146.	ADRA1B ADRA2A GPR171 TACR3 F2RL2 CX3CR1	4.67e-07	102	32	6	MODULE_146
Computational	Genes in the cancer module 289.	ADRA2A GPR171 TACR3 CX3CR1	4.72e-04	124	32	4	MODULE_289
Drug	pimozide	CACNA1A CACNA1B CACNA1E CACNA1S ADRA1B ADRA1A ADRA2A TPCN2 TRPV6 ITPR1	4.50e-12	127	68	10	CID000016362
Drug	Cinildipine	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	3.19e-10	56	68	7	CID000002752
Drug	nilvadipine	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	5.26e-10	60	68	7	CID000004494
Drug	nitrendipine	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 SLC30A4 ITPR1	5.26e-10	98	68	8	CID000004507
Drug	CNS 1145	CACNA1A CACNA1B CACNA1E CACNA1S TRPV6 ITPR1	5.89e-10	33	68	6	CID000190902
Drug	IHC-64	CACNA1A CACNA1B CACNA1E CACNA1S TRPV6 ITPR1	5.89e-10	33	68	6	CID000162753
Drug	lercanidipine	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	7.48e-10	63	68	7	CID000065866
Drug	gallopamil	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	1.16e-09	67	68	7	CID000001234
Drug	AC1L2AC7	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	1.44e-09	69	68	7	CID000068733
Drug	CAS 298-57-7	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	2.15e-09	73	68	7	CID000002761
Drug	BMY 7378	CACNA1A CACNA1B ADRA1B ADRA1A ADRA2A TMEM121	2.35e-09	41	68	6	CID000002419
Drug	ethosuximide	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	2.37e-09	74	68	7	CID000003291
Drug	nifedipine	CACNA1A CACNA1B CACNA1E CACNA1S ADRA1B ADRA1A ADRA2A TPCN2 TRPV6 TACR3 CYP39A1 ITPR1	3.33e-09	415	68	12	CID000004485
Drug	nisoldipine	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	3.45e-09	78	68	7	CID000004499
Drug	lanthanum	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 TRPV5 ITPR1	7.20e-09	136	68	8	CID000023926
Drug	manidipine	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	1.39e-08	95	68	7	CID000004008
Drug	Bay K 8644	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 TRPV5 ITPR1	1.56e-08	150	68	8	CID000002303
Drug	isradipine	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	1.98e-08	100	68	7	CID000003784
Drug	verapamil	CACNA1A CACNA1B CACNA1E CACNA1S ADRA1B ADRA1A ADRA2A TPCN2 KCNE5 TRPV6 MSTN ITPR1	2.11e-08	490	68	12	CID000002520
Drug	IAA-94	CACNA1A CACNA1B CACNA1E CACNA1S TRPV6 ITPR1	2.76e-08	61	68	6	CID000003667
Drug	loperamide	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	2.79e-08	105	68	7	CID000003954
Drug	gabapentin	CACNA1A CACNA1B CACNA1E CACNA1S ADRA2A TPCN2 TRPV6 ITPR1	3.95e-08	169	68	8	CID000003446
Drug	felodipine	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 CYP39A1 ITPR1	3.95e-08	169	68	8	CID000003333
Drug	A61603	CACNA1A CACNA1B ADRA1B ADRA1A ADRA2A	4.55e-08	33	68	5	CID004038180
Drug	guanethidine	CACNA1A CACNA1B CACNA1E ADRA1B ADRA1A ADRA2A TACR3	4.64e-08	113	68	7	CID000003518
Drug	lamotrigine	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	5.57e-08	116	68	7	CID000003878
Drug	bepridil	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	9.85e-08	126	68	7	CID000002351
Drug	AC 110	CACNA1A CACNA1B CACNA1E	1.02e-07	4	68	3	CID000022860
Drug	BE 2254	ADRA1B ADRA1A TAAR1	1.02e-07	4	68	3	ctd:C010652
Drug	dihydropyridine	CACNA1A CACNA1B CACNA1E CACNA1S SSPN TPCN2 TRPV6 ITPR1	1.10e-07	193	68	8	CID000104822
Drug	N-cyclopentyl-N-cyclobutylformamide	CACNA1A CACNA1B CACNA1E CACNA1S TRPV6 ITPR1	1.33e-07	79	68	6	CID005287890
Drug	Fk 888	CACNA1A CACNA1B CACNA1E TACR3 TRPV5	1.60e-07	42	68	5	CID000107967
Drug	U46619	CACNA1A CACNA1B CACNA1E CACNA1S ADRA1B ADRA1A TRPV6 MSTN ITPR1	1.72e-07	285	68	9	CID000005618
Drug	capsazepine	CACNA1A CACNA1B CACNA1E TRPV6 TACR3 TRPV5	1.92e-07	84	68	6	CID002733484
Drug	brimonidine	CACNA1A CACNA1B CACNA1E ADRA1B ADRA1A ADRA2A	2.21e-07	86	68	6	CID000002435
Drug	5-methylgramine	ADRA1B ADRA1A ADRA2A	2.54e-07	5	68	3	CID000034855
Drug	Leniquinsin	ADRA1B ADRA1A ADRA2A	2.54e-07	5	68	3	CID000025195
Drug	2-Dtmi	ADRA1B ADRA1A ADRA2A	2.54e-07	5	68	3	CID000127572
Drug	metazosin	ADRA1B ADRA1A ADRA2A	2.54e-07	5	68	3	CID000093514
Drug	S-10089	ADRA1B ADRA1A ADRA2A	2.54e-07	5	68	3	CID000146399
Drug	AC1O6ABX	ADRA1B ADRA1A ADRA2A	2.54e-07	5	68	3	CID006449894
Drug	CS-263	ADRA1B ADRA1A ADRA2A	2.54e-07	5	68	3	CID000137303
Drug	KABI 2023	ADRA1B ADRA1A ADRA2A	2.54e-07	5	68	3	CID000192124
Drug	A-53693	ADRA1B ADRA1A ADRA2A	2.54e-07	5	68	3	CID003082713
Drug	Dantrolene-13C3	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	2.57e-07	145	68	7	CID000002951
Drug	nimodipine	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	2.57e-07	145	68	7	CID000004497
Drug	nicardipine	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	2.57e-07	145	68	7	CID000004473
Drug	DAPs	SLC24A5 CACNA1A CACNA1B CACNA1E SSPN MSTN	3.30e-07	92	68	6	CID000146339
Drug	Doxepin	ADRA1B ADRA1A ADRA2A HRH2	3.40e-07	20	68	4	DB01142
Drug	procaine	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	3.71e-07	153	68	7	CID000004914
Drug	ARC 239	ADRA1B ADRA1A ADRA2A TACR3	4.19e-07	21	68	4	CID000609483
Drug	isotetrandrine	CACNA1A CACNA1B CACNA1E CACNA1S TRPV6 ITPR1	4.52e-07	97	68	6	CID000005422
Drug	Xylometazoline	ADRA1B ADRA1A ADRA2A	5.06e-07	6	68	3	DB06694
Drug	dibozane	ADRA1B ADRA1A ADRA2A	5.06e-07	6	68	3	CID000094342
Drug	Dextroamphetamine	ADRA1B ADRA1A TAAR1	5.06e-07	6	68	3	DB01576
Drug	3,4-dihydroquinazoline	CACNA1A CACNA1B CACNA1E	5.06e-07	6	68	3	CID000583065
Drug	alpha-sialylcholesterol	CACNA1A CACNA1B CACNA1E	5.06e-07	6	68	3	CID000133976
Drug	Epinastine	ADRA1A ADRA2A HRH2	5.06e-07	6	68	3	DB00751
Drug	droperidol	CACNA1B ADRA1B ADRA1A ADRA2A	6.17e-07	23	68	4	CID000003168
Drug	AC1L1F6H	CACNA1A CACNA1B CACNA1E ADRA1B ADRA1A ADRA2A	7.65e-07	106	68	6	CID000003104
Drug	alfuzosin	CACNA1E ADRA1B ADRA1A ADRA2A	8.78e-07	25	68	4	CID000002092
Drug	xylometazoline	ADRA1B ADRA1A ADRA2A	8.84e-07	7	68	3	ctd:C009695
Drug	APMPA	CACNA1A CACNA1B CACNA1E	8.84e-07	7	68	3	CID000512300
Drug	NSC7524	CACNA1A CACNA1B CACNA1E CACNA1S TRPV6 MSTN ITPR1	1.19e-06	182	68	7	CID000005657
Drug	potassium	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 SLC24A4 ATP6V0A4 KCNE5 TRPV6 XK MSTN TRPV5 CX3CR1 ITPR1	1.34e-06	1008	68	14	CID000000813
Drug	alprenolol	ADRA1B ADRA1A ADRA2A TAAR1 TMEM121	1.36e-06	64	68	5	CID000002119
Drug	mibefradil	CACNA1A CACNA1B CACNA1S TPCN2 TRPV6	1.36e-06	64	68	5	CID000060662
Drug	AC1NBU2S	CACNA1A CACNA1B CACNA1E CACNA1S TRPV6 ITPR1	1.37e-06	117	68	6	CID004473765
Drug	Oxymetazoline	ADRA1B ADRA1A ADRA2A	1.41e-06	8	68	3	ctd:D010109
Drug	tiodazosin	ADRA1B ADRA1A ADRA2A	1.41e-06	8	68	3	CID000060891
Drug	Epinephrine	ADRA1B ADRA1A ADRA2A	1.41e-06	8	68	3	DB00668
Drug	Dimebon	CACNA1A ADRA1B ADRA1A	1.41e-06	8	68	3	CID000197033
Drug	xylometazoline	ADRA1B ADRA1A ADRA2A	1.41e-06	8	68	3	CID000005709
Drug	5-methylurapidil	CACNA1A ADRA1B ADRA1A ADRA2A	1.63e-06	29	68	4	CID000005640
Drug	NSC759576	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	1.65e-06	191	68	7	CID000003075
Drug	Calcium	CACNA1A CACNA1B CACNA1E ADRA1B ADRA1A ADRA2A TRPV6 TRPV5 ITPR1 ITPR2	1.95e-06	493	68	10	ctd:D002118
Drug	felodipine; Up 200; 10uM; MCF7; HG-U133A	CACNA1A CACNA1E SLC15A2 IL1RAPL2 HRH2 LAPTM5 ITPR2	2.02e-06	197	68	7	337_UP
Drug	SB-273779	ADRA1B ADRA1A ADRA2A	2.11e-06	9	68	3	CID005311133
Drug	p-menthane	ADRA1B ADRA1A ADRA2A	2.11e-06	9	68	3	CID000007459
Drug	guanadrel	ADRA1B ADRA1A ADRA2A	2.11e-06	9	68	3	CID000038521
Drug	Nefazodone	ADRA1B ADRA1A ADRA2A	2.11e-06	9	68	3	DB01149
Drug	phenethylamine	ADRA1A ADRA2A TAAR1	2.11e-06	9	68	3	ctd:C029261
Drug	dipivefrin	ADRA1B ADRA1A ADRA2A	2.11e-06	9	68	3	CID000003105
Drug	gadolinium	CACNA1A CACNA1B CACNA1E CACNA1S TRPV6 TRPV5 ITPR1	2.17e-06	199	68	7	CID000023982
Drug	cobalt-60	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 RNF19A TRPV6 SLC30A4 ITPR1	2.34e-06	390	68	9	CID000061492
Drug	Barium	CACNA1A CACNA1B CACNA1E ADRA1A TRPV6	2.45e-06	72	68	5	ctd:D001464
Drug	Doxazosin	ADRA1B ADRA1A ADRA2A MSTN	2.46e-06	32	68	4	ctd:D017292
Drug	AC1L1DXE	CACNA1A CACNA1B CACNA1E CACNA1S TRPV6 TACR3 TRPV5 ITPR1	3.01e-06	299	68	8	CID000002548
Drug	Norepinephrine	ADRA1B ADRA1A ADRA2A	3.01e-06	10	68	3	DB00368
Drug	azapetine	ADRA1B ADRA1A ADRA2A	3.01e-06	10	68	3	CID000008966
Drug	Droxidopa	ADRA1B ADRA1A ADRA2A	3.01e-06	10	68	3	DB06262
Drug	trimazosin	ADRA1B ADRA1A ADRA2A	3.01e-06	10	68	3	CID000037264
Drug	L-659,066	ADRA1B ADRA1A ADRA2A	3.01e-06	10	68	3	CID000163952
Drug	Ergotamine	ADRA1B ADRA1A ADRA2A	3.01e-06	10	68	3	DB00696
Drug	fluspirilene	CACNA1A CACNA1B CACNA1E ADRA2A	3.15e-06	34	68	4	CID000003396
Drug	phendioxan	CACNA1A ADRA1B ADRA1A ADRA2A	3.55e-06	35	68	4	CID000185453
Drug	epinastine	ADRA1B ADRA1A ADRA2A HRH2	3.99e-06	36	68	4	CID000003241
Drug	phenytoin	CACNA1A CACNA1B CACNA1E CACNA1S TPCN2 TRPV6 ITPR1	4.08e-06	219	68	7	CID000001775
Drug	leys	CACNA1A CACNA1B CACNA1E	4.13e-06	11	68	3	CID000484683
Drug	tramazoline	ADRA1B ADRA1A ADRA2A	4.13e-06	11	68	3	CID000005524
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1A CACNA1B CACNA1E	9.73e-09	3	64	3	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1A CACNA1B CACNA1E	3.89e-08	4	64	3	DOID:6364 (implicated_via_orthology)
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1A CACNA1B CACNA1E	3.38e-07	7	64	3	DOID:0050951 (implicated_via_orthology)
Disease	Anoxic Encephalopathy	ITPR1 ITPR2	4.63e-06	2	64	2	C0003132
Disease	Brain Hypoxia	ITPR1 ITPR2	4.63e-06	2	64	2	C1527348
Disease	Anoxia of brain	ITPR1 ITPR2	4.63e-06	2	64	2	C0995195
Disease	Hypoxic Brain Damage	ITPR1 ITPR2	4.63e-06	2	64	2	C1140716
Disease	pigmentation disease (is_implicated_in)	TPCN2 SLC24A4	2.52e-04	11	64	2	DOID:10123 (is_implicated_in)
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR2	3.01e-04	12	64	2	DOID:1441 (implicated_via_orthology)
Disease	age of onset of multiple sclerosis	SGMS1 ITPR1	3.01e-04	12	64	2	OBA_2001029
Disease	cutaneous melanoma, hair color	SLC24A5 TPCN2 SLC24A4	3.36e-04	62	64	3	EFO_0000389, EFO_0003924
Disease	epilepsy (implicated_via_orthology)	CACNA1A CACNA1B CACNA1E SLC24A4	4.41e-04	163	64	4	DOID:1826 (implicated_via_orthology)
Disease	S-adenosylhomocysteine measurement	CACNA1B ADRA1A	6.17e-04	17	64	2	EFO_0010531
Disease	Schizophrenia	CACNA1B SLC6A12 ADRA1A ADRA2A NRXN3 NRXN2 TAAR1 TACR3	6.27e-04	883	64	8	C0036341
Disease	Cardiac Hypertrophy	ADRA1B ADRA2A ITPR2	7.63e-04	82	64	3	C1383860
Disease	Cardiomegaly	ADRA1B ADRA2A ITPR2	7.63e-04	82	64	3	C0018800
Disease	polycystic ovary syndrome (biomarker_via_orthology)	ADRA1B ADRA1A	9.47e-04	21	64	2	DOID:11612 (biomarker_via_orthology)
Disease	Movement Disorders	CACNA1B XK	1.81e-03	29	64	2	C0026650
Disease	hair colour measurement	SLC24A5 SSPN TPCN2 SLC24A4 LGR4 SERINC5	2.15e-03	615	64	6	EFO_0007822

Protein segments in the cluster

Peptide	Gene	Start	Entry
LPYVCLLIAMLFFIY	CACNA1A	1691	O00555
LFGMVLVLGAVYYCL	ELFN1	426	P0C7U0
CLLIAMLFFIYAIIG	CACNA1E	1611	Q15878
GSFYLPLAIILVMYC	ADRA1A	191	P35348
SFYIPLAVILVMYCR	ADRA1B	211	P35368
LLPLLIMSYCYFRII	CX3CR1	201	P49238
CIMRYSVPILILLYL	DPY19L3	521	Q6ZPD9
FYIIYMAILLTHRCL	DHCR7	431	Q9UBM7
YVCLLIAMLFFIYAI	CACNA1B	1601	Q00975
KLGVYVLVLYAIFLC	SLC24A4	586	Q8NFF2
FLYHVAYVLVCMLGL	ITPR2	2346	Q14571
ISLVIFYGLICMYTL	LRRC8A	326	Q8IWT6
FIVAYALIFLLCMVG	NPFFR1	46	Q9GZQ6
VITLPFMCILVSYGY	OR1J2	206	Q8NGS2
YKLVELLCYVVMGFF	MMD2	181	Q8IY49
LYHLLYLVICAMGLF	ITPR1	2401	Q14643
LLIMLKSEGFYSYLC	SLC43A2	36	Q8N370
LYILLIMIFYACLAG	KCNE5	61	Q9UJ90
AVYVCILLGNGMLLY	OR51B2	31	Q9Y5P1
YYALMLVICILLLDA	OR51V1	206	Q9H2C8
ACLIYINMYLSIIFL	GPR171	91	O14626
FYLPLLIMCITYYRI	HRH2	191	P25021
AAAALCILILLYAMY	NRXN3	1576	Q9Y4C0
LAFLLMAVIYTKLYC	LGR4	716	Q9BXB1
LLMLCSLLTSLYVFY	HS3ST3A1	26	Q9Y663
CLLLVVMSYDLYVAI	OR2A7	111	Q96R45
MLVCVLLYSFRLFGI	IGHV8-51-1	1	P0DTE2
CLLLVVMSYDLYVAI	OR2A4	111	O95047
VIFYGNMYCSILLLA	F2RL2	171	O00254
ALCILILLYAMYKYR	NRXN2	601	P58401
SYPGMLVCIYFIILF	CACNA1S	631	Q13698
IMVILVLGYGIFHCY	SLC44A2	266	Q8IWA5
LLEVQMCIILILYKY	CYP39A1	421	Q9NYL5
MCIILILYKYDCSLL	CYP39A1	426	Q9NYL5
HSEGCLLLLLYMYIT	ATRIP	626	Q8WXE1
LLLVICLIFSIMGYY	SLC15A2	681	Q16348
LCYALFLAMYLTTLL	OR1E2	26	P47887
LCYALFLAMYLTTLL	OR1E1	26	P30953
LFLLFLLLYLMILCG	OR10Q1	31	Q8NGQ4
ILYLIFYICELVGMS	SLC9C1	251	Q4G0N8
MYALLGVFCLAILVF	TMEM132E	891	Q6IEE7
MDYLLCLLTLLGSYI	LAPTM5	101	Q13571
LVVIYKCYNIELMLF	IL1RAPL2	371	Q9NP60
AAALCILILLYAMYK	NRXN3	571	Q9HDB5
LCVYIYLFMLIVAGP	MSTN	6	O14793
LTIAVMCYLIGLFLV	SLC6A12	426	P48065
AIVALYFILVMCIGF	SLC5A3	11	P53794
LVAYLGLFMLCVSYQ	SSPN	96	Q14714
FIIGTLYLYRCITMY	SGMS2	161	Q8NHU3
YCFPLLIMGITYTIV	TACR3	256	P29371
LSVSIFYICLLMYIG	OR5K4	246	A6NMS3
YLCVLLIVAGVALFM	SLC35B1	141	P78383
FAPCLIMILVYVRIY	ADRA2A	221	P08913
GLGLLNDILLTYCMY	TBC1D17	396	Q9HA65
IMLAYVYGVVPISLC	RNF19A	441	Q9NV58
SYMLGIFICNLLLYL	SIDT1	711	Q9NXL6
GLTFFYCYMLLLVLP	TMEM121	181	Q9BTD3
RFMYALYFILVVVLC	SERINC5	36	Q86VE9
YSMFLCVHVKLYILL	UNC93A	401	Q86WB7
MLGAIYLLYIICFTM	TRPV6	371	Q9H1D0
IYGLYVLVLCFDIKI	SLC24A5	206	Q71RS6
FCIVGTLYLYRCITM	SGMS1	216	Q86VZ5
IPGSIMLCVYYRIYL	TAAR1	201	Q96RJ0
YLVLMLIVYIFECAS	UPK1A	96	O00322
MLCLIAILLYVLVQY	ZDHHC11	181	Q9H8X9
IFILCLFGYLVFMII	ATP6V0A4	581	Q9HBG4
ISVLLVYILMGFLLY	SLC30A4	186	O14863
MLCLIAILLYVLVQY	ZDHHC11B	181	P0C7U3
LGFFIMCVYVYLILP	TEX2	476	Q8IWB9
DIYMYVCAPLLVLQL	XK	341	P51811
LIGYCTAILFMLVFY	XK	356	P51811
ILNCVFIVYYLLEML	TPCN2	471	Q8NHX9
ILAALYLLYMICFTT	TRPV5	331	Q9NQA5
CLGAYIIMLFFLFIL	TMPPE	121	Q6ZT21