Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Pubmed	Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.	GFAP DYNC1H1 ITPR1	1.27e-06	17	44	3	20395553
Pubmed	Combinatorial roles of the nuclear receptor corepressor in transcription and development.	NCOR1 GFAP	1.56e-05	5	44	2	11030619
Pubmed	Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.	NCOR1 GFAP	2.34e-05	6	44	2	18829436
Pubmed	A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis.	NCOR1 GFAP	2.34e-05	6	44	2	15852015
Pubmed	Peroxisomal localization in the developing mouse cerebellum: implications for neuronal abnormalities related to deficiencies in peroxisomes.	GFAP ITPR1	2.34e-05	6	44	2	15026142
Pubmed	Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid.	PDGFRB GFAP	2.34e-05	6	44	2	24828044
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NAP1L3 RNF38 CCAR1 TOLLIP PDGFRB GFAP TRIM37 DYNC1H1 RASAL2	2.75e-05	1285	44	9	35914814
Pubmed	Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice.	GFAP ITPR1	3.27e-05	7	44	2	8863127
Pubmed	Ganglioside GD3 is required for neurogenesis and long-term maintenance of neural stem cells in the postnatal mouse brain.	ST8SIA1 GFAP	3.27e-05	7	44	2	25297105
Pubmed	CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development.	PDGFRB GFAP	3.27e-05	7	44	2	28827364
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CIZ1 EXOC6B XPO4 IPO8 PIH1D1 RFX1 DYNC1H1 RASAL2 NUP205	3.42e-05	1321	44	9	27173435
Pubmed	Msx1 and Msx2 are expressed in sub-populations of vascular smooth muscle cells.	PDGFRB GFAP	5.60e-05	9	44	2	18627106
Pubmed	Nkx2.1 regulates the generation of telencephalic astrocytes during embryonic development.	PDGFRB GFAP	6.99e-05	10	44	2	28266561
Pubmed	FAM19A5 Expression During Embryogenesis and in the Adult Traumatic Brain of FAM19A5-LacZ Knock-in Mice.	PDGFRB GFAP	6.99e-05	10	44	2	31543758
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	PPP1R13B IPO8 PTPRE PIH1D1 DYNC1H1 NUP205	8.08e-05	573	44	6	28330616
Pubmed	NG2 glia are required for vessel network formation during embryonic development.	PDGFRB GFAP	8.54e-05	11	44	2	26651999
Pubmed	Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice.	PDGFRB EPHA8	8.54e-05	11	44	2	24550361
Pubmed	Death receptors DR6 and TROY regulate brain vascular development.	PDGFRB GFAP	8.54e-05	11	44	2	22340501
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	PPP1R13B NCOR1 IPO8 PIH1D1 TRIM37 DYNC1H1 NUP205	9.05e-05	853	44	7	28718761
Pubmed	Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability.	PARD6B PDGFRB	1.02e-04	12	44	2	32044971
Pubmed	Oligodendrogenesis and Myelin Formation in the Forebrain Require Platelet-derived Growth Factor Receptor-alpha.	PDGFRB GFAP	1.02e-04	12	44	2	32278722
Pubmed	Huntingtin interacting proteins are genetic modifiers of neurodegeneration.	NCOR1 GFAP DYNC1H1 ITPR1	1.14e-04	197	44	4	17500595
Pubmed	Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice.	RFX1 GFAP	1.21e-04	13	44	2	35087169
Pubmed	PRELP secreted from mural cells protects the function of blood brain barrier through regulation of endothelial cell-cell integrity.	PDGFRB GFAP	1.21e-04	13	44	2	37936982
Pubmed	The missense mutation C667F in murine β-dystroglycan causes embryonic lethality, myopathy and blood-brain barrier destabilization.	PDGFRB GFAP	1.21e-04	13	44	2	38616731
Pubmed	Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.	GFAP ITPR1	1.41e-04	14	44	2	34630045
Pubmed	The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.	PDGFRB GFAP	1.41e-04	14	44	2	22144466
Pubmed	A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis.	PDGFRB GFAP	1.63e-04	15	44	2	28535372
Pubmed	Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method.	NAP1L3 GFAP	1.86e-04	16	44	2	9417904
Pubmed	Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.	PDGFRB GFAP	1.86e-04	16	44	2	33253712
Pubmed	Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad.	PDGFRB GFAP	1.86e-04	16	44	2	18397758
Pubmed	Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis.	PDGFRB GFAP	1.86e-04	16	44	2	31761722
Pubmed	Enlarged lateral ventricles and aberrant behavior in mice overexpressing PDGF-B in embryonic neural stem cells.	PDGFRB GFAP	1.86e-04	16	44	2	20643125
Pubmed	Assignment of 22 loci in the rat by somatic hybrid and linkage analysis.	PDGFRB GFAP	2.36e-04	18	44	2	8268657
Pubmed	Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice.	PDGFRB GFAP	2.36e-04	18	44	2	36280666
Pubmed	Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain.	PDGFRB GFAP	2.36e-04	18	44	2	36450771
Pubmed	Endothelial Arid1a deletion disrupts the balance among angiogenesis, neurogenesis and gliogenesis in the developing brain.	PDGFRB GFAP	2.64e-04	19	44	2	36916004
Pubmed	Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo.	PDGFRB GFAP	2.64e-04	19	44	2	28111199
Pubmed	BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response.	PDGFRB GFAP	2.93e-04	20	44	2	29483282
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	KIAA1549 PPP1R13B XPO4 NCOR1 PTPRE PIH1D1 ITPR1	3.22e-04	1049	44	7	27880917
Pubmed	METTL3-mediated m6A modification is required for cerebellar development.	DAPK1 GFAP	3.24e-04	21	44	2	29879109
Pubmed	DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential.	PDGFRB GFAP	3.56e-04	22	44	2	35998585
Pubmed	A human MAP kinase interactome.	PARD6B PPP1R13B TOLLIP TSC22D1 GFAP	3.62e-04	486	44	5	20936779
Pubmed	Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development.	PDGFRB GFAP	3.89e-04	23	44	2	36103829
Pubmed	PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.	GFAP ITPR1	4.24e-04	24	44	2	28413018
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	PPP1R13B TRIM37 DYNC1H1	4.78e-04	120	44	3	31413325
Pubmed	Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.	PARD6B PPP1R13B XPO4 MAN2A2	5.14e-04	293	44	4	31741433
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIAA1549 XPO4 ARHGAP4 ESPL1 NUP205	5.32e-04	529	44	5	14621295
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	XPO4 IPO8	5.38e-04	27	44	2	23027611
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	CIZ1 CCAR1 PARD6B IPO8 ESPL1 DYNC1H1 ITPR1	5.72e-04	1155	44	7	20360068
Pubmed	Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.	GFAP ITPR1	6.21e-04	29	44	2	32123907
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CIZ1 PPP1R13B NCOR1 RFX1 DYNC1H1	6.29e-04	549	44	5	38280479
Pubmed	Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches.	PDGFRB GFAP	6.65e-04	30	44	2	31953387
Pubmed	A genetic approach to Mammalian glycan function.	ST8SIA1 MAN2A2	6.65e-04	30	44	2	12676797
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	DAPK1 TSC22D1 PDGFRB PLBD2 TRIM37 TENT2 ITPR1	7.72e-04	1215	44	7	15146197
Pubmed	Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.	RFX1 GFAP	8.06e-04	33	44	2	30914320
Pubmed	Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.	GFAP DYNC1H1	8.06e-04	33	44	2	26025364
Pubmed	Regulation of prefrontal patterning and connectivity by retinoic acid.	GFAP EPHA8	8.55e-04	34	44	2	34599305
Pubmed	Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.	TOLLIP PIH1D1	8.55e-04	34	44	2	21492153
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	GFAP DYNC1H1 ITPR1	8.63e-04	147	44	3	16959763
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	RFX1 DYNC1H1 ITPR1 NUP205	8.95e-04	340	44	4	29478914
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	TOLLIP NCOR1 IPO8 TRIM37 PPFIA4	9.93e-04	608	44	5	16713569
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	TOLLIP PTPRE GFAP DYNC1H1 ITPR1	1.09e-03	621	44	5	22794259
Pubmed	140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.	PTPRE DYNC1H1 ITPR1	1.16e-03	163	44	3	16512683
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R13B NCOR1 ITPR1	3.28e-03	181	30	3	694
GeneFamily	Sterile alpha motif domain containing	PPFIA4 EPHA8	9.33e-03	88	30	2	760
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DAPK1 ST8SIA1 P2RX5 PPFIA4 ITPR1	6.04e-07	165	44	5	479962ce1c3d6636ae62b6709635299748653801
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DAPK1 ST8SIA1 PDGFRB TRIM37	1.74e-05	157	44	4	c779a53b2c67d566f5d417e753cd17196a6bfd1c
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PARD6B N4BP2L1 ST8SIA1 PPFIA4	1.92e-05	161	44	4	ed93cb6c133855a5c244821e1a260aae8ab4df9a
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PARD6B N4BP2L1 ST8SIA1 PPFIA4	1.92e-05	161	44	4	0089d7bb305c592392791862a3341fc92af8f3e2
ToppCell	droplet-Lung-nan-3m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC63 DAPK1 ST8SIA1 PPFIA4	1.97e-05	162	44	4	8a488ecd25ef41468c3c7766eb936dbc2f7665a9
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NKPD1 MAN2A2 ESPL1 PPFIA4	1.97e-05	162	44	4	b502d6af6868425b5c919740e011330c0d3cf3b8
ToppCell	facs-Marrow-T-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSC22D1 ST8SIA1 PPFIA4 ITPR1	2.43e-05	171	44	4	6a0fafb8fd9fc7671618eeb2bf528ce8ce86b794
ToppCell	facs-Marrow-T-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSC22D1 ST8SIA1 PPFIA4 ITPR1	2.43e-05	171	44	4	e02b5831768dbb1b68998b672e55c9680ab0cc86
ToppCell	wk_08-11-Mesenchymal-Chondrocyte-intermediate_chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	LRRC63 TSC22D1 P2RX5 GFAP	2.48e-05	172	44	4	415d57aa6278b8c12e7a2cf9c3fa5283389fb9b0
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSC22D1 ST8SIA1 PPFIA4 ITPR1	2.97e-05	180	44	4	df60970520fba2ac0639faa54096766d07418ca4
ToppCell	facs-Marrow-B-cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSC22D1 ST8SIA1 PPFIA4 ITPR1	3.03e-05	181	44	4	e2481291c236105774c53883e6f20da11941df9b
ToppCell	facs-Marrow-B-cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSC22D1 ST8SIA1 PPFIA4 ITPR1	3.03e-05	181	44	4	782716b8b1d447d2bbe09a693fa5ed7ebeac0efb
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY1 PPFIA4 ITPR1 EPHA8	3.59e-05	189	44	4	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	Mesenchymal_cells-Fibro/Chondro_p.\|Mesenchymal_cells / Lineage and Cell class	KIAA1549 TSC22D1 PTPRE GFAP	4.06e-05	195	44	4	b95a631d54c6cf85e48e1e638703206aaaebc073
Disease	Carcinoma, Transitional Cell	NCOR1 DAPK1 ESPL1	2.75e-05	41	42	3	C0007138
Disease	Phenyllactate (PLA) measurement	DAPK1 IPO8	3.33e-04	19	42	2	EFO_0021662
Disease	Infiltrating duct carcinoma of female breast	PDGFRB EPHA8	4.08e-04	21	42	2	C3165106
Disease	attention function measurement	MSH4 TENT2 ITPR1	1.23e-03	148	42	3	EFO_0007636
Disease	Gastric Adenocarcinoma	PDGFRB EPHA8	1.88e-03	45	42	2	C0278701
Disease	Malignant neoplasm of salivary gland	DAPK1 ESPL1	1.88e-03	45	42	2	C0220636
Disease	Salivary Gland Neoplasms	DAPK1 ESPL1	2.05e-03	47	42	2	C0036095
Disease	developmental disorder of mental health (implicated_via_orthology)	NCOR1 RASAL2	2.23e-03	49	42	2	DOID:0060037 (implicated_via_orthology)
Disease	X-12063 measurement	EXOC6B XPO4 TENT2	2.36e-03	186	42	3	EFO_0021283
Disease	Peripheral Nervous System Diseases	DAPK1 GFAP	2.70e-03	54	42	2	C4721453

Protein segments in the cluster

Peptide	Gene	Start	Entry
RGLFIQQLRPTQNLQ	DAPK1	671	P53355
RSSQQQTQPQKQRVF	CCAR1	136	Q8IX12
RTQLQREIQLLFPQS	TENT2	181	Q6PIY7
QTQEQRTQRNVINVP	PPP1R13B	96	Q96KQ4
QILQTVRIPSQRQAI	NUP205	671	Q92621
NLIITVRPANQRNNV	PARD6B	241	Q9BYG5
VANIQQRQKLQIPSV	KIAA1549	1336	Q9HCM3
IRDFLVTLNQPQARQ	PTPRE	566	P23469
LQTRQPVFVQLLQGV	ITPR1	1511	Q14643
LILQIPTQNTQARQV	PPFIA4	1076	O75335
PKVRAIQRQQTQQVQ	RASAL2	931	Q9UJF2
RQANVQIQEIQRTPQ	L1RE1	191	Q9UN81
RNQSLTPINIQNIFL	LRRC63	61	Q05C16
QQRNLDNIVLQQPRI	EXOC6B	226	Q9Y2D4
RITIPVQTFSNLQIR	GFAP	376	P14136
AQLSIISQPRVRQQI	MROH8	391	Q9H579
VRSLQVPQLQQVGQL	ADCY1	111	Q08828
PRVQQRVQTRLKVNF	ESPL1	1381	Q14674
NQAAPSQVVVIRQER	EPHA8	436	P29322
SQIRVQRVPVSNVNL	FCRL3	276	Q96P31
RQFRVQAVQPTLILQ	MBLAC2	136	Q68D91
NFPRSQISVLQNRIE	MAN2A2	41	P49641
VRVLRPQVTAVAQQN	DYNC1H1	481	Q14204
QLSFQLQINVPVRVL	PDGFRB	406	P09619
FFVVTNLIVTPNQRQ	P2RX5	101	Q93086
QIFLPRIQQQIVQLL	IPO8	176	O15397
NPQNDTVILRFQVRS	TRIM37	391	O94972
FQTQQSRSPLQRIEN	RNF38	296	Q9H0F5
QTQQLRVLQQPVFLA	SUPT20HL1	776	Q3ZLR7
QQNIRSEQRPRIQEL	PIH1D1	176	Q9NWS0
TVPITVRLLQQQQQQ	NKPD1	406	Q17RQ9
PTQVVQQVQGTQQRL	RFX1	131	P22670
LLQQQQQQQLRRRPS	NCOR1	56	O75376
TANPSIIRQRFQNLL	ST8SIA1	186	Q92185
TQITRQILQNQRSTP	MSH4	866	O15457
PQAVRNRVQALRNIQ	NAP1L3	101	Q99457
QQQQPTVNTSRFRVV	TSC22D1	396	Q15714
NQLVQTLIVQPDRVF	ARHGAP4	681	P98171
QVLPRFQPRVLQVQA	CIZ1	306	Q9ULV3
FQPRVLQVQAQVQSQ	CIZ1	311	Q9ULV3
LQVQAQVQSQTQPRI	CIZ1	316	Q9ULV3
QSEVARRFQVSQPQI	TIGD3	31	Q6B0B8
LQPLQQRFLRVINQE	XPO4	776	Q9C0E2
FLRITPTQQQRQVQL	TOLLIP	21	Q9H0E2
SPRAQIFRRNQSLVQ	PLBD2	456	Q8NHP8
FIRTRLLLQFTQPQQ	ZHX1-C8orf76	236	Q96EF9
RLSLQPQQQQQRQRP	N4BP2L1	11	Q5TBK1