Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR1 RYR2 RYR3

1.37e-094153GO:0005219
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR1 RYR2 RYR3

6.85e-096153GO:0048763
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR1 RYR2 RYR3

2.78e-0718153GO:0015278
GeneOntologyMolecularFunctionligand-gated calcium channel activity

RYR1 RYR2 RYR3

1.52e-0631153GO:0099604
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR1 RYR2 RYR3

1.85e-0633153GO:0005217
GeneOntologyMolecularFunctioncalcium channel activity

RYR1 RYR2 RYR3

1.13e-04129153GO:0005262
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

RYR1 RYR2 RYR3

1.44e-04140153GO:0099094
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

RYR1 RYR2 RYR3

1.80e-04151153GO:0015085
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

RYR1 RYR2 RYR3

3.71e-04193153GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

RYR1 RYR2 RYR3

3.94e-04197153GO:0022834
GeneOntologyMolecularFunctioncalmodulin binding

RYR1 RYR2 RYR3

6.20e-04230153GO:0005516
GeneOntologyMolecularFunctiongated channel activity

RYR1 RYR2 RYR3

1.82e-03334153GO:0022836
GeneOntologyMolecularFunctioncalcium ion binding

RYR1 RYR2 RYR3 FBN2

1.93e-03749154GO:0005509
GeneOntologyMolecularFunctionmonoatomic cation channel activity

RYR1 RYR2 RYR3

1.96e-03343153GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion channel activity

RYR1 RYR2 RYR3

4.47e-03459153GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

RYR1 RYR2 RYR3

4.63e-03465153GO:0046873
GeneOntologyMolecularFunctionchannel activity

RYR1 RYR2 RYR3

6.50e-03525153GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

RYR1 RYR2 RYR3

6.53e-03526153GO:0022803
GeneOntologyMolecularFunctiontranscription coregulator activity

CCAR1 PHF10 KMT2C

7.84e-03562153GO:0003712
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

RYR1 RYR2 RYR3

1.06e-02627153GO:0022890
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

RYR1 RYR2 RYR3

1.24e-02664153GO:0008324
GeneOntologyMolecularFunctionhistone modifying activity

PHF10 KMT2C

1.25e-02229152GO:0140993
GeneOntologyBiologicalProcesscellular response to caffeine

RYR1 RYR2 RYR3

6.30e-0811163GO:0071313
GeneOntologyBiologicalProcesscellular response to purine-containing compound

RYR1 RYR2 RYR3

1.39e-0714163GO:0071415
GeneOntologyBiologicalProcessresponse to caffeine

RYR1 RYR2 RYR3

5.05e-0721163GO:0031000
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum

RYR1 RYR2 RYR3

2.93e-0637163GO:0014808
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by endoplasmic reticulum

RYR1 RYR2 RYR3

3.44e-0639163GO:1903514
GeneOntologyBiologicalProcesscellular response to alkaloid

RYR1 RYR2 RYR3

3.72e-0640163GO:0071312
GeneOntologyBiologicalProcesssarcoplasmic reticulum calcium ion transport

RYR1 RYR2 RYR3

4.97e-0644163GO:0070296
GeneOntologyBiologicalProcessresponse to alkaloid

RYR1 RYR2 RYR3

1.15e-04125163GO:0043279
GeneOntologyBiologicalProcesscellular response to ATP

RYR1 RYR3

1.17e-0421162GO:0071318
GeneOntologyBiologicalProcessnegative regulation of cytosolic calcium ion concentration

RYR2 RYR3

1.67e-0425162GO:0051481
GeneOntologyBiologicalProcessresponse to magnesium ion

RYR2 RYR3

1.67e-0425162GO:0032026
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

RYR1 RYR2 RYR3

1.82e-04146163GO:0051209
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

RYR1 RYR2 RYR3

1.86e-04147163GO:0051283
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

RYR1 RYR2 RYR3

1.93e-04149163GO:0051282
GeneOntologyBiologicalProcessmaintenance of location

RYR1 RYR2 RYR3 FBN2

2.03e-04396164GO:0051235
GeneOntologyBiologicalProcesssequestering of calcium ion

RYR1 RYR2 RYR3

2.09e-04153163GO:0051208
GeneOntologyBiologicalProcessresponse to calcium ion

RYR1 RYR2 RYR3

2.43e-04161163GO:0051592
GeneOntologyBiologicalProcessresponse to purine-containing compound

RYR1 RYR2 RYR3

2.65e-04166163GO:0014074
GeneOntologyBiologicalProcessresponse to ATP

RYR1 RYR3

4.33e-0440162GO:0033198
GeneOntologyBiologicalProcesscalcium ion transport

RYR1 RYR2 RYR3 TSPAN18

5.27e-04509164GO:0006816
GeneOntologyBiologicalProcessstriated muscle contraction

RYR1 RYR2 RYR3

5.81e-04217163GO:0006941
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

RYR1 RYR2 RYR3

5.81e-04217163GO:0097553
GeneOntologyBiologicalProcessossification

CSGALNACT1 DNAJC13 RYR1 FBN2

7.64e-04562164GO:0001503
GeneOntologyBiologicalProcessmaintenance of location in cell

RYR1 RYR2 RYR3

9.71e-04259163GO:0051651
GeneOntologyBiologicalProcesscalcium-mediated signaling

RYR1 RYR2 RYR3

1.05e-03266163GO:0019722
GeneOntologyBiologicalProcessinorganic ion homeostasis

RYR1 RYR2 RYR3 BTBD9

1.12e-03622164GO:0098771
GeneOntologyBiologicalProcessprotein homotetramerization

RYR1 RYR3

1.60e-0377162GO:0051289
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

RYR1 RYR2 RYR3 BTBD9

1.77e-03705164GO:0055080
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

RYR1 RYR2 RYR3 BTBD9

1.89e-03717164GO:0050801
GeneOntologyBiologicalProcessregulation of cytosolic calcium ion concentration

RYR1 RYR2

1.90e-0384162GO:0051480
GeneOntologyBiologicalProcesschemical homeostasis

RYR1 RYR2 RYR3 FBN2 BTBD9

2.01e-031249165GO:0048878
GeneOntologyBiologicalProcesscellular response to calcium ion

RYR1 RYR3

2.08e-0388162GO:0071277
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

RYR1 RYR2 RYR3

2.47e-03359163GO:0006874
GeneOntologyBiologicalProcesscalcium ion homeostasis

RYR1 RYR2 RYR3

3.11e-03389163GO:0055074
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

RYR1 RYR2 RYR3

3.17e-03392163GO:0070588
GeneOntologyBiologicalProcessmuscle contraction

RYR1 RYR2 RYR3

3.36e-03400163GO:0006936
GeneOntologyBiologicalProcessprotein tetramerization

RYR1 RYR3

3.40e-03113162GO:0051262
GeneOntologyBiologicalProcessadult locomotory behavior

OXR1 BTBD9

3.57e-03116162GO:0008344
GeneOntologyBiologicalProcessresponse to metal ion

RYR1 RYR2 RYR3

3.73e-03415163GO:0010038
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

RYR1 RYR2 RYR3

5.12e-0645163GO:0033017
GeneOntologyCellularComponentsmooth endoplasmic reticulum

RYR1 RYR2 RYR3

5.47e-0646163GO:0005790
GeneOntologyCellularComponentjunctional membrane complex

RYR1 RYR3

1.97e-059162GO:0030314
GeneOntologyCellularComponentcalcium channel complex

RYR1 RYR2 RYR3

2.21e-0573163GO:0034704
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

RYR1 RYR2

2.46e-0510162GO:0014701
GeneOntologyCellularComponentsarcoplasmic reticulum

RYR1 RYR2 RYR3

3.88e-0588163GO:0016529
GeneOntologyCellularComponentsarcoplasm

RYR1 RYR2 RYR3

8.40e-05114163GO:0016528
GeneOntologyCellularComponentZ disc

RYR1 RYR2 RYR3

1.93e-04151163GO:0030018
GeneOntologyCellularComponentI band

RYR1 RYR2 RYR3

2.55e-04166163GO:0031674
GeneOntologyCellularComponentcytoplasmic side of plasma membrane

RYR1 RYR2 RYR3

3.51e-04185163GO:0009898
GeneOntologyCellularComponentsarcolemma

RYR1 RYR2 RYR3

3.79e-04190163GO:0042383
GeneOntologyCellularComponentcytoplasmic side of membrane

RYR1 RYR2 RYR3

6.62e-04230163GO:0098562
GeneOntologyCellularComponentcation channel complex

RYR1 RYR2 RYR3

7.05e-04235163GO:0034703
GeneOntologyCellularComponentextrinsic component of cytoplasmic side of plasma membrane

RYR1 RYR2

8.26e-0456162GO:0031234
GeneOntologyCellularComponentsarcomere

RYR1 RYR2 RYR3

8.34e-04249163GO:0030017
GeneOntologyCellularComponentmyofibril

RYR1 RYR2 RYR3

1.09e-03273163GO:0030016
GeneOntologyCellularComponentcontractile muscle fiber

RYR1 RYR2 RYR3

1.29e-03290163GO:0043292
GeneOntologyCellularComponentsupramolecular fiber

RYR1 RYR2 RYR3 DNAH17 FBN2

1.46e-031179165GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

RYR1 RYR2 RYR3 DNAH17 FBN2

1.51e-031187165GO:0099081
GeneOntologyCellularComponentmonoatomic ion channel complex

RYR1 RYR2 RYR3

2.76e-03378163GO:0034702
GeneOntologyCellularComponentextrinsic component of plasma membrane

RYR1 RYR2

4.82e-03137162GO:0019897
GeneOntologyCellularComponenttransmembrane transporter complex

RYR1 RYR2 RYR3

6.84e-03523163GO:1902495
GeneOntologyCellularComponenttransporter complex

RYR1 RYR2 RYR3

7.86e-03550163GO:1990351
GeneOntologyCellularComponentextrinsic component of membrane

RYR1 RYR2

1.31e-02230162GO:0019898
MousePhenodecreased body length

OXR1 ZC3H14 CSGALNACT1 RYR1 FBN2 BTBD9

6.41e-06484156MP:0001258
MousePhenoabnormal body length

OXR1 ZC3H14 CSGALNACT1 RYR1 FBN2 BTBD9

1.33e-05550156MP:0001256
MousePhenoabnormal paired-pulse ratio

RYR2 BTBD9

2.25e-057152MP:0014252
MousePhenoabnormal sarcoplasmic reticulum morphology

RYR1 RYR2

2.68e-0423152MP:0004088
DomainRR_TM4-6

RYR1 RYR2 RYR3

4.19e-103153PF06459
DomainRyanrecept_TM4-6

RYR1 RYR2 RYR3

4.19e-103153IPR009460
DomainRyR

RYR1 RYR2 RYR3

4.19e-103153PF02026
DomainRyanodine_rcpt

RYR1 RYR2 RYR3

4.19e-103153IPR003032
DomainRyan_recept

RYR1 RYR2 RYR3

4.19e-103153IPR013333
DomainRIH_assoc

RYR1 RYR2 RYR3

8.37e-096153PF08454
DomainRIH_assoc-dom

RYR1 RYR2 RYR3

8.37e-096153IPR013662
DomainIns145_P3_rec

RYR1 RYR2 RYR3

8.37e-096153PF08709
DomainRYDR_ITPR

RYR1 RYR2 RYR3

8.37e-096153PF01365
DomainRIH_dom

RYR1 RYR2 RYR3

8.37e-096153IPR000699
DomainIns145_P3_rcpt

RYR1 RYR2 RYR3

8.37e-096153IPR014821
DomainRyanodine_recept-rel

RYR1 RYR2 RYR3

8.37e-096153IPR015925
Domain-

RYR1 RYR2 RYR3

8.37e-0961531.25.10.30
DomainMIR

RYR1 RYR2 RYR3

5.01e-0810153PS50919
DomainMIR

RYR1 RYR2 RYR3

5.01e-0810153PF02815
DomainMIR

RYR1 RYR2 RYR3

5.01e-0810153SM00472
DomainMIR_motif

RYR1 RYR2 RYR3

5.01e-0810153IPR016093
DomainSPRY

RYR1 RYR2 RYR3

4.27e-0587153SM00449
DomainSPRY

RYR1 RYR2 RYR3

5.38e-0594153PF00622
DomainSPRY_dom

RYR1 RYR2 RYR3

5.38e-0594153IPR003877
DomainB30.2/SPRY

RYR1 RYR2 RYR3

5.55e-0595153IPR001870
DomainB302_SPRY

RYR1 RYR2 RYR3

5.55e-0595153PS50188
DomainEF-hand-dom_pair

CCAR1 RYR1 RYR2 RYR3

6.52e-05287154IPR011992
DomainIon_trans_dom

RYR1 RYR2 RYR3

9.55e-05114153IPR005821
DomainIon_trans

RYR1 RYR2 RYR3

9.55e-05114153PF00520
DomainEF-hand_8

RYR1 RYR2

3.33e-0434152PF13833
DomainConA-like_dom

RYR1 RYR2 RYR3

6.52e-04219153IPR013320
DomainEF_hand_dom

RYR1 RYR2 RYR3

7.71e-04232153IPR002048
Domain-

RYR1 RYR2 RYR3

1.08e-032611531.10.238.10
DomainPHD

PHF10 KMT2C

1.62e-0375152PF00628
DomainZnf_PHD-finger

PHF10 KMT2C

1.79e-0379152IPR019787
DomainPHD

PHF10 KMT2C

2.26e-0389152SM00249
DomainZnf_PHD

PHF10 KMT2C

2.37e-0391152IPR001965
DomainZF_PHD_2

PHF10 KMT2C

2.57e-0395152PS50016
DomainZF_PHD_1

PHF10 KMT2C

2.63e-0396152PS01359
DomainZnf_FYVE_PHD

PHF10 KMT2C

6.04e-03147152IPR011011
DomainEF-hand_1

RYR2 RYR3

6.44e-03152152PF00036
DomainEF_HAND_2

RYR2 RYR3

1.44e-02231152PS50222
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

RYR1 RYR2 RYR3

1.01e-0711133M47958
PathwayWP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING

RYR1 RYR2 RYR3

1.74e-0713133M39589
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR1 RYR2 RYR3

5.89e-0719133M47760
PathwayREACTOME_ION_HOMEOSTASIS

RYR1 RYR2 RYR3

1.48e-0554133M27460
PathwayREACTOME_ION_HOMEOSTASIS

RYR1 RYR2 RYR3

1.48e-0554133MM15202
PathwayREACTOME_STIMULI_SENSING_CHANNELS

RYR1 RYR2 RYR3

9.13e-0599133MM14910
PathwayREACTOME_CARDIAC_CONDUCTION

RYR1 RYR2 RYR3

1.03e-04103133MM15196
PathwayREACTOME_STIMULI_SENSING_CHANNELS

RYR1 RYR2 RYR3

1.12e-04106133M27200
PathwayREACTOME_CARDIAC_CONDUCTION

RYR1 RYR2 RYR3

2.05e-04130133M27454
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

RYR1 RYR2 RYR3

2.94e-04147133MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

RYR1 RYR2 RYR3

3.18e-04151133M39329
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

RYR1 RYR2 RYR3

3.37e-04154133MM15974
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

RYR1 RYR2 RYR3

3.50e-04156133M39475
PathwayREACTOME_MUSCLE_CONTRACTION

RYR1 RYR2 RYR3

4.13e-04165133MM15026
PathwayREACTOME_ION_CHANNEL_TRANSPORT

RYR1 RYR2 RYR3

4.99e-04176133MM15718
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

RYR1 RYR2 RYR3

5.16e-04178133M2890
PathwayREACTOME_ION_CHANNEL_TRANSPORT

RYR1 RYR2 RYR3

5.59e-04183133M997
PathwayREACTOME_MUSCLE_CONTRACTION

RYR1 RYR2 RYR3

7.56e-04203133M5485
PathwayWP_15Q25_COPY_NUMBER_VARIATION

RYR1 RYR2

7.94e-0446132M48105
PathwayWP_GPCRS_ODORANT

GPR19 GPR108

8.87e-03157132MM15872
Pubmed

Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.

RYR1 RYR2 RYR3

7.99e-11316325239916
Pubmed

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.

RYR1 RYR2 RYR3

7.99e-1131637621815
Pubmed

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

RYR1 RYR2 RYR3

7.99e-1131639204703
Pubmed

A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.

RYR1 RYR2 RYR3

7.99e-11316318643873
Pubmed

Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).

RYR1 RYR2 RYR3

7.99e-11316311159936
Pubmed

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

RYR1 RYR2 RYR3

7.99e-1131637876312
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR1 RYR2 RYR3

7.99e-1131639242641
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR1 RYR2 RYR3

7.99e-11316318403125
Pubmed

Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

RYR1 RYR2 RYR3

7.99e-11316321881589
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR1 RYR2 RYR3

7.99e-11316322948152
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR1 RYR2 RYR3

7.99e-11316310788707
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR1 RYR2 RYR3

7.99e-11316318434746
Pubmed

Molecular identification of the ryanodine receptor pore-forming segment.

RYR1 RYR2 RYR3

7.99e-11316310473538
Pubmed

Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.

RYR1 RYR2 RYR3

7.99e-1131637959768
Pubmed

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

RYR1 RYR2 RYR3

7.99e-11316312213830
Pubmed

The organization of proteins in the human red blood cell membrane. A review.

RYR1 RYR2 RYR3

7.99e-1131634600883
Pubmed

Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.

RYR1 RYR2 RYR3

7.99e-1131637635066
Pubmed

Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.

RYR1 RYR2 RYR3

3.19e-1041639384575
Pubmed

A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.

RYR1 RYR2 RYR3

3.19e-10416318206662
Pubmed

Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.

RYR1 RYR2 RYR3

3.19e-1041639607712
Pubmed

Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.

RYR1 RYR2 RYR3

3.19e-10416323482488
Pubmed

Ryanodine receptor calcium release channels: lessons from structure-function studies.

RYR1 RYR2 RYR3

3.19e-10416323413940
Pubmed

Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.

RYR1 RYR2 RYR3

7.98e-10516319011160
Pubmed

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

RYR1 RYR2 RYR3

7.98e-10516323918386
Pubmed

Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.

RYR1 RYR2 RYR3

1.60e-09616319549818
Pubmed

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

RYR1 RYR2 RYR3

1.60e-09616319009018
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR1 RYR2 RYR3

1.60e-09616316844763
Pubmed

Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.

RYR1 RYR2 RYR3

1.60e-09616326025922
Pubmed

FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.

RYR1 RYR2 RYR3

1.60e-09616314592808
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR1 RYR2 RYR3

1.60e-09616323463619
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR1 RYR2 RYR3

1.60e-09616320519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR1 RYR2 RYR3

1.60e-09616325966694
Pubmed

Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.

RYR1 RYR2 RYR3

2.79e-09716320962236
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR1 RYR2 RYR3

2.79e-09716311860456
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

RYR1 RYR2 RYR3

4.47e-09816311784029
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR1 RYR2 RYR3

4.47e-09816319033399
Pubmed

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

RYR1 RYR2 RYR3

1.75e-081216319095005
Pubmed

Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.

RYR1 RYR3

1.98e-07216212565913
Pubmed

Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.

RYR1 RYR3

1.98e-0721629489997
Pubmed

Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.

RYR1 RYR2

1.98e-07216217259277
Pubmed

Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.

RYR1 RYR3

1.98e-07216215894801
Pubmed

Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.

RYR1 RYR3

1.98e-0721629192302
Pubmed

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.

RYR1 RYR2

1.98e-07216230542613
Pubmed

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.

RYR1 RYR2

1.98e-07216225370123
Pubmed

The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.

RYR1 RYR3

1.98e-07216212640042
Pubmed

Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.

RYR2 RYR3

1.98e-07216214985349
Pubmed

The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.

RYR2 RYR3

1.98e-07216214550562
Pubmed

Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.

RYR1 RYR2

1.98e-07216215033925
Pubmed

Ryanodine receptor oligomeric interaction: identification of a putative binding region.

RYR1 RYR2

1.98e-07216214722100
Pubmed

Structural and functional interactions within ryanodine receptor.

RYR1 RYR2

1.98e-07216226009179
Pubmed

Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.

RYR1 RYR2

1.98e-07216215280431
Pubmed

Expression of the ryanodine receptor isoforms in immune cells.

RYR1 RYR2

1.98e-07216211673493
Pubmed

B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.

RYR1 RYR2

1.98e-07216211673462
Pubmed

Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.

RYR1 RYR3

1.98e-0721627556644
Pubmed

Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.

RYR1 RYR2

1.98e-07216218618700
Pubmed

Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.

RYR2 RYR3

1.98e-07216221531043
Pubmed

Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.

RYR1 RYR2

1.98e-07216232899693
Pubmed

Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.

RYR1 RYR3

1.98e-07216214592949
Pubmed

Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.

RYR1 RYR3

1.98e-0721629799464
Pubmed

Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.

RYR2 RYR3

1.98e-07216216678258
Pubmed

Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.

RYR1 RYR3

1.98e-07216217118445
Pubmed

Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.

RYR1 RYR3

1.98e-0721629817784
Pubmed

Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.

RYR2 RYR3

1.98e-0721628898078
Pubmed

RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.

RYR1 RYR3

1.98e-07216211500519
Pubmed

Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.

RYR1 RYR2

5.95e-07316223278119
Pubmed

Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.

RYR1 RYR3

5.95e-07316211171121
Pubmed

Intracellular calcium release channel expression during embryogenesis.

RYR1 RYR2

5.95e-0731629986730
Pubmed

Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.

RYR1 RYR2

5.95e-07316224123915
Pubmed

Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.

RYR1 RYR3

5.95e-07316218313230
Pubmed

Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.

RYR1 RYR2

5.95e-07316223454728
Pubmed

RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.

RYR2 RYR3

5.95e-07316215024040
Pubmed

Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.

RYR2 RYR3

5.95e-07316229730765
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

RYR1 RYR2 RYR3

6.67e-073816330786075
Pubmed

Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.

RYR1 RYR3

1.19e-06416222100703
Pubmed

Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.

RYR1 RYR2

1.19e-06416219120137
Pubmed

Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.

RYR1 RYR2

1.19e-06416222504960
Pubmed

FKBP binding characteristics of cardiac microsomes from diverse vertebrates.

RYR1 RYR2

1.19e-06416211237759
Pubmed

Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.

RYR1 RYR2

1.19e-06416223992453
Pubmed

S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.

RYR1 RYR2

1.19e-06416227226555
Pubmed

Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.

RYR1 RYR2

1.98e-06516222939628
Pubmed

Intracellular calcium-release channels: regulators of cell life and death.

RYR1 RYR2

1.98e-0651629124414
Pubmed

Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.

RYR2 RYR3

1.98e-06516233060591
Pubmed

Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.

RYR1 RYR3

2.97e-06616210444070
Pubmed

ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.

RYR1 RYR3

5.55e-06816230563862
Pubmed

Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.

RYR1 RYR3

5.55e-06816221441923
Pubmed

Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.

RYR1 RYR3

7.13e-06916221858002
Pubmed

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.

RYR1 RYR2

8.91e-061016218434328
Pubmed

MED12 regulates a transcriptional network of calcium-handling genes in the heart.

RYR1 RYR2

1.80e-051416228724790
Pubmed

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

RYR1 RYR2 RYR3

3.66e-0514316320424473
Pubmed

FOXL2 modulates cartilage, skeletal development and IGF1-dependent growth in mice.

RYR1 FBN2

1.38e-043816226134413
Pubmed

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

KMT2C DNAH17 TSPAN18

2.28e-0426516319240061
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

CCAR1 PHF10 ZC3H14 DNAJC13

2.78e-0472416436232890
Pubmed

ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.

RYR1 RYR2

3.12e-045716223788249
Pubmed

A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.

PHF10 KMT2C

3.57e-046116220305087
InteractionRYR2 interactions

RYR1 RYR2 RYR3

1.23e-0558163int:RYR2
InteractionAKAP6 interactions

RYR1 RYR2

7.98e-0517162int:AKAP6
InteractionSP7 interactions

CCAR1 PHF10 KMT2C FBN2

8.01e-05304164int:SP7
InteractionRYR3 interactions

RYR2 RYR3

1.61e-0424162int:RYR3
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR1 RYR2 RYR3

2.90e-103133287
GeneFamilyPHD finger proteins

PHF10 KMT2C

1.84e-039013288
GeneFamilyEF-hand domain containing

RYR2 RYR3

1.04e-02219132863
CoexpressionFAN_EMBRYONIC_CTX_EX_4_EXCITATORY_NEURON

CSGALNACT1 RYR2 RYR3

1.31e-04166163M39026
CoexpressionLAKE_ADULT_KIDNEY_C15_CONNECTING_TUBULE

KMT2C CSGALNACT1 BTBD9

1.44e-04171163M39234
CoexpressionGSE22229_UNTREATED_VS_IMMUNOSUPP_THERAPY_RENAL_TRANSPLANT_PATIENT_PBMC_UP

KMT2C CSGALNACT1 DNAH17

2.28e-04200163M7478
CoexpressionGSE25123_WT_VS_PPARG_KO_MACROPHAGE_ROSIGLITAZONE_STIM_UP

CSGALNACT1 DNAJC13 RYR1

2.28e-04200163M7978
CoexpressionGSE32128_INOS_DEPENDENT_VS_INOS_INDEPENDENT_ACTIVATED_TCELL_DN

OXR1 RYR3 FBN2

2.28e-04200163M8602
CoexpressionGSE2585_CTEC_VS_MTEC_THYMUS_UP

KMT2C DNAJC13 TSPAN18

2.28e-04200163M6265
CoexpressionHALLMARK_KRAS_SIGNALING_DN

RYR1 RYR2 GPR19

2.28e-04200163M5956
CoexpressionCASORELLI_APL_SECONDARY_VS_DE_NOVO_UP

CSGALNACT1 FBN2

2.55e-0439162M13339
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#5_top-relative-expression-ranked_1000

KMT2C CSGALNACT1 RYR1 RYR2

1.82e-05219164gudmap_developingGonad_e16.5_ovary_1000_k5
CoexpressionAtlasDevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#5_top-relative-expression-ranked_200

RYR3 TSPAN18

2.92e-0511162gudmap_developingKidney_e15.5_Ureteral Smooth Musc_200_k5
CoexpressionAtlasdev gonad_e12.5_F_SupCellPrec_Sry_k-means-cluster#2_top-relative-expression-ranked_100

CSGALNACT1 RYR2

1.11e-0421162gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_k2_100
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_1000

KMT2C CSGALNACT1 DNAJC13 RYR2 GPR19

2.01e-04776165gudmap_developingGonad_e14.5_ ovary_1000
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000

KMT2C CSGALNACT1 DNAJC13 RYR1 RYR2

2.25e-04795165gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#5_top-relative-expression-ranked_1000

KMT2C CSGALNACT1 RYR2

3.04e-04179163gudmap_developingGonad_e14.5_ ovary_1000_k5
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 RYR3 FBN2

2.39e-05160163c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 RYR3 FBN2

2.39e-0516016325c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellfacs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RYR3 FBN2 TSPAN18

2.67e-051661635e3b998d740b24f790fad37350d704ca0ea10b77
ToppCellfacs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RYR3 FBN2 TSPAN18

2.67e-05166163bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

OXR1 DNAH17 FBN2

3.17e-05176163327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

OXR1 DNAH17 FBN2

3.57e-0518316392fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 RYR3 FBN2

3.62e-05184163ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 RYR3 FBN2

3.62e-051841632cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 RYR3 FBN2

3.62e-051841632b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RYR2 RYR3 FBN2

3.68e-051851637dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

CSGALNACT1 RYR2 FBN2

3.92e-051891635e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

OXR1 CSGALNACT1 RYR1

4.64e-05200163dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

OXR1 CSGALNACT1 RYR1

4.64e-05200163a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

KMT2C CSGALNACT1 TSPAN18

4.64e-05200163dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

OXR1 CSGALNACT1 RYR1

4.64e-0520016321bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

OXR1 CSGALNACT1 RYR1

4.64e-052001633bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

OXR1 CSGALNACT1 RYR1

4.64e-0520016333036d21c1c82109284473a515c4f890b33fdd5c
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

OXR1 CSGALNACT1 RYR1

4.64e-05200163a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Rln3_(parabrachial_pigmented_nucleus_(PBP))-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

RYR1 DNAH17

4.46e-0488162b4620e79ea80681305434707e87cb02a7c6a5e4f
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Rln3_(parabrachial_pigmented_nucleus_(PBP))--|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

RYR1 DNAH17

4.46e-04881627992f8e621edf464bffcb70a6cc5f3b60c1d96f8
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Rln3_(parabrachial_pigmented_nucleus_(PBP))|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

RYR1 DNAH17

4.46e-0488162b7b55f51af8ffa82813a4747580985a430da9ed1
ToppCellCOVID-19-kidney-Epithelial_Doublet|kidney / Disease (COVID-19 only), tissue and cell type

RYR1 RYR2

8.82e-04124162d6f59ddb9b9df02b5201f23fa5fb78f3fd891ee9
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RYR1 RYR3

9.10e-041261629b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Ptgfr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RYR1 RYR3

9.24e-04127162fb58f4b4d3722f4b9a2e4946c0244c5b70dd883b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH17 FBN2

9.39e-04128162076ba9de63b9a4b5a2f7e7924b9a86e8eafce91f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH17 FBN2

9.68e-041301627d4319aae42acc914757796877b8f0d874acbec4
ToppCellCOVID-19_Mild-Classical_Monocyte-|COVID-19_Mild / Disease condition and Cell class

CSGALNACT1 DNAJC13

9.83e-04131162ae5eb9c013674b36987bf26d4f752dbb374f547b
ToppCellLPS-antiTNF-Unknown-Endothelial-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RYR2 RYR3

9.98e-0413216202491930097b75aaeedab9e8200711b0dc610944
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_PT|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RYR1 RYR3

1.03e-03134162cb676d5bbc468bd3ce1b6712d41c986ee9221ac5
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Cdh13|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RYR1 RYR3

1.06e-031361621f3000d5f105c87c80f8ae1dd2264bcd7f757a9c
ToppCellLPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHF10 RYR2

1.06e-03136162a2063abe2d7c3277bfbe1514c8c66363cf04b248
ToppCellLPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like-Erythroid|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHF10 RYR2

1.07e-031371628e2fa2ef8becace96a68bb85c002329110902fbb
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RYR1 RYR3

1.12e-031401627cc891d676555609add6fc7880735d948a2ad801
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

RYR1 RYR3

1.19e-0314416208005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

RYR2 FBN2

1.22e-03146162c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FBN2 TSPAN18

1.25e-031481629205b26e0d042b342cc643cda0f4f3f8bb392d00
ToppCellCOVID-19-kidney-Technical/muscle|kidney / Disease (COVID-19 only), tissue and cell type

RYR2 FBN2

1.25e-031481620dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCellVE-CD8-memory_CD4|VE / Condition, Cell_class and T cell subcluster

RYR3 TSPAN18

1.32e-031521629401b7770c1bdc87eba25e82922f5dd1c4fa37ee
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Conventional_Leiomyosarcoma|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

RYR2 RYR3

1.34e-03153162ec6fe6b8c884fa76adc7a0f9db041f7b1567a2ee
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSGALNACT1 RYR1

1.35e-031541625ed64bbf603290e6dc34f81d145982690b89dd0d
ToppCellTCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue-3|TCGA-Thryoid / Sample_Type by Project: Shred V9

CSGALNACT1 RYR2

1.35e-031541624e9203c220a44c70cd7979796a0b461991422257
ToppCellfacs-Heart-RA-24m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 RYR3

1.41e-031571629021900d9b1a71210c9c414a9d165eaf399eb607
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CSGALNACT1 TSPAN18

1.41e-03157162275a4c6fef1fff8da2bdc48e3924ad05c5e5cfc8
ToppCellfacs-Heart-RA-24m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 RYR3

1.41e-03157162c8c627ca181856cd31dba4cf073c2be659a49dc1
ToppCellTCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue|TCGA-Thryoid / Sample_Type by Project: Shred V9

CSGALNACT1 RYR2

1.42e-031581628e48952af0831a1fc71ad422e8216b5a92a75991
ToppCellTCGA-Thryoid-Solid_Tissue_Normal|TCGA-Thryoid / Sample_Type by Project: Shred V9

CSGALNACT1 RYR2

1.42e-0315816255214d674808584e4d48f8c5e3b8c0e206cb9bb8
ToppCellTCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue|TCGA-Thryoid / Sample_Type by Project: Shred V9

CSGALNACT1 RYR2

1.42e-03158162e5b55c15a8c99c8d7fc94949f0d3c22e0c3fee7b
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR3 FBN2

1.44e-031591624000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

RYR1 RYR2

1.44e-031591625335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR3 FBN2

1.44e-031591627619d0d49738dd08daf01b42664691a5323aa793
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal|GW19 / Sample Type, Dataset, Time_group, and Cell type.

PHF10 DNAH17

1.44e-03159162f34f2729a3872fbb2939e76ad35d7e25f71b8f57
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal-Unfolded_protein_responsible_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

PHF10 DNAH17

1.44e-03159162929ed98f6c2ad14e8d5af5c6f11a5a3d4b388cf7
ToppCellGlobus_pallidus-Neuronal-Excitatory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

RYR1 RYR3

1.46e-03160162f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

RYR3 TSPAN18

1.46e-03160162d783d29150033e9181c0e30870070268fed3fd85
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

RYR1 RYR3

1.48e-03161162ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

RYR2 RYR3

1.48e-0316116264891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

RYR1 RYR2

1.51e-0316316219c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma|TCGA-Endometrium / Sample_Type by Project: Shred V9

RYR1 GPR19

1.53e-0316416208c725548e751f815b4df778607270498204b353
ToppCellTCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-7|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

FBN2 TSPAN18

1.53e-0316416281c41e1b5535b7969bcf6fa2456f828e8e8e2ff7
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RYR3 FBN2

1.53e-03164162d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CSGALNACT1 RYR3

1.53e-031641621cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCellEndothelial-B-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

CSGALNACT1 TSPAN18

1.55e-03165162b6893882472aeb0d18e26f47eaec9d53688afcde
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Teffector/EM_CD4|GI_small-bowel / Manually curated celltypes from each tissue

CSGALNACT1 TSPAN18

1.55e-03165162ecaeb90a6bc27524ef6f2eefa72aec7315dbde3b
ToppCellEndothelial-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

RYR2 TSPAN18

1.59e-031671626a03d16165e0b003092c39972928981abd4a75aa
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-9|TCGA-Brain / Sample_Type by Project: Shred V9

CSGALNACT1 RYR1

1.59e-03167162013971700e80b71e4b8c79b8fff0d8beeac295c3
ToppCellEndothelial-B-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

CSGALNACT1 TSPAN18

1.63e-0316916295c617143e1fbdd1d55a93ffdcc210e0be37cf2f
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CSGALNACT1 TSPAN18

1.63e-031691620d8b681404e18f3061d84425fb5f7d84e8e2b8d7
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 RYR3

1.63e-0316916212bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR3 TSPAN18

1.64e-03170162021c3e45955d18e241f7d98acdf22076fee4fc43
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-6_VIP_RCN1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBN2 TSPAN18

1.64e-0317016217b8c53c69d78d1b343a5f86d4f82896deee1b0d
ToppCellCOVID-19-Heart-T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

RYR1 RYR3

1.66e-03171162b2e753e811a7639956994609f73efcdb62d04f82
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH17 TSPAN18

1.68e-03172162490745024730df6357f6c2b81d7a64e21557c0d5
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

RYR2 RYR3

1.70e-03173162a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 RYR3

1.70e-0317316266f37c1437705734b20601656fa4aa1d92ca30be
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR2 RYR3

1.70e-03173162649b08a409095592cccf31883be69c754411280d
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CSGALNACT1 GPR19

1.72e-03174162b43fb0fbb492c1be6e791a1c4d6c4e5956955ee4
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high|PND01-03-samps / Age Group, Lineage, Cell class and subclass

CSGALNACT1 TSPAN18

1.72e-03174162cb0109661e8c9ca04d67d33f2d926f0e649bf67d
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CSGALNACT1 GPR19

1.72e-0317416294575a605c725de83f66a6cf7df9d7bb360ffc56
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH17 FBN2

1.72e-0317416246bd0ef7d0541386de7a901d85d53d0176dc92bf
ToppCellBAL-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CSGALNACT1 GPR19

1.72e-0317416240c81ab36d7931e271e20d7d56fed32463c75f41
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR3 TSPAN18

1.72e-03174162e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Tnaive/CM_CD4|GI_small-bowel / Manually curated celltypes from each tissue

CSGALNACT1 TSPAN18

1.74e-031751624b77e9cf712c9e3b4fb68462a96aea47be124e8d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR3 TSPAN18

1.74e-0317516290e29945aa861082c94bb4f331161adc3a6ef899
ToppCelldroplet-Kidney-nan-18m-Endothelial-kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSGALNACT1 TSPAN18

1.76e-031761625386386619cf173939d3c117b20e6f27ab397993
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)|390C / Donor, Lineage, Cell class and subclass (all cells)

RYR2 FBN2

1.76e-03176162852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCellControl-Neuronal_cells|Control / group, cell type (main and fine annotations)

CSGALNACT1 TSPAN18

1.76e-03176162c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCellControl-Neuronal_cells-Neuronal_cells|Control / group, cell type (main and fine annotations)

CSGALNACT1 TSPAN18

1.76e-0317616298c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR3 TSPAN18

1.76e-03176162e4b21fd6a5e0c5950f27c3e1868318e48330ae5e
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|390C / Donor, Lineage, Cell class and subclass (all cells)

RYR2 FBN2

1.76e-03176162d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCelldroplet-Kidney-nan-18m-Endothelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSGALNACT1 TSPAN18

1.76e-03176162820edade963768e4bfd86b554da4cd7100567ac8
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

OXR1 DNAH17

1.78e-03177162da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR3 TSPAN18

1.78e-03177162bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR3 TSPAN18

1.78e-0317716257033ee0d49a4a50fc25328a4a44d4de2b35f505
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

OXR1 RYR3

1.80e-03178162a0ab20c588e7d43d0320d4779d9ab95c1c86e297
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D231|Adult / Lineage, Cell type, age group and donor

CSGALNACT1 TSPAN18

1.80e-03178162c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH17 FBN2

1.82e-0317916255bc69f107fc710db7617c428575792adfdbbcc1
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR3 TSPAN18

1.82e-031791627954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCellhuman_hepatoblastoma-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

OXR1 RYR2

1.82e-0317916214fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PHF10 CSGALNACT1

1.82e-03179162d2db9e70b780643f1e004c41a70464d0abe26088
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RYR3 TSPAN18

1.84e-03180162a499548391e6833b78f6e920f8e32a755814a9da
ComputationalNeighborhood of MAGEA8

PHF10 RYR1 RYR3 GPR19

2.01e-04260134MORF_MAGEA8
ComputationalNeighborhood of FSHR

PHF10 RYR1 RYR3 GPR19

2.64e-04279134MORF_FSHR
ComputationalNeighborhood of CAMK4

PHF10 RYR1 RYR3 GPR19

3.06e-04290134MORF_CAMK4
ComputationalNeighborhood of SUPT3H

PHF10 RYR1 RYR3 GPR19

4.89e-04328134MORF_SUPT3H
ComputationalNeighborhood of RAD51L3

PHF10 RYR1 RYR3 GPR19

9.13e-04387134MORF_RAD51L3
ComputationalNeighborhood of DMPK

PHF10 RYR3 GPR19

1.08e-03175133MORF_DMPK
ComputationalNeighborhood of PRKCA

PHF10 RYR3 GPR19

1.19e-03181133MORF_PRKCA
ComputationalNeighborhood of MAP2K7

PHF10 RYR3 GPR19

1.19e-03181133MORF_MAP2K7
ComputationalNeighborhood of BCL2L11

PHF10 RYR3 GPR19

1.28e-03186133MORF_BCL2L11
ComputationalNeighborhood of CTSB

PHF10 RYR3 GPR19

1.30e-03187133MORF_CTSB
ComputationalNeighborhood of IL4

PHF10 RYR3 GPR19

1.41e-03192133MORF_IL4
ComputationalNeighborhood of IFNA1

RYR1 RYR3 GPR19

1.70e-03205133MORF_IFNA1
ComputationalNeighborhood of IL16

PHF10 RYR3 GPR19

2.63e-03239133MORF_IL16
ComputationalIon channels.

RYR1 RYR2

3.11e-0370132MODULE_316
ComputationalNeighborhood of PTPRB

PHF10 RYR3 GPR19

3.13e-03254133MORF_PTPRB
ComputationalNeighborhood of MDM2

PHF10 RYR3 GPR19

4.08e-03279133MORF_MDM2
ComputationalNeighborhood of NOS2A

PHF10 RYR3 GPR19

4.46e-03288133MORF_NOS2A
ComputationalNeighborhood of PTEN

PHF10 GPR19

4.56e-0385132MORF_PTEN
ComputationalNeighborhood of MLLT10

PHF10 RYR3 GPR19

5.09e-03302133MORF_MLLT10
ComputationalNeighborhood of ARL3

PHF10 RYR3 GPR19

5.19e-03304133MORF_ARL3
ComputationalNeighborhood of ERCC4

PHF10 RYR3 GPR19

6.04e-03321133MORF_ERCC4
ComputationalNeighborhood of PTPRR

RYR3 GPR19

6.50e-03102132MORF_PTPRR
ComputationalNeighborhood of ATF2

PHF10 RYR3 GPR19

6.52e-03330133MORF_ATF2
Drug2-hydroxyheptanoic acid

RYR1 RYR2 RYR3

2.85e-103163CID002750949
Drug2-hydroxycarbazole

RYR1 RYR2 RYR3

2.85e-103163CID000093551
Drugaminodantrolene

RYR1 RYR2 RYR3

2.85e-103163CID009570289
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR1 RYR2 RYR3

2.85e-103163CID005748312
Drug8N3-cADPR

RYR1 RYR2 RYR3

2.85e-103163CID000127713
Drugcis-diammineplatinum(II

RYR1 RYR2 RYR3

2.85e-103163CID000159790
DrugAC1L1U7A

RYR1 RYR2 RYR3

1.14e-094163CID000035682
DrugPCB74

RYR1 RYR2 RYR3

1.14e-094163CID000036218
DrugSC 38249

RYR1 RYR2 RYR3

1.14e-094163CID000134834
Drug148504-47-6

RYR1 RYR2 RYR3

1.14e-094163CID006444275
DrugNSC114784

RYR1 RYR2 RYR3

5.69e-096163CID000419425
DrugMBED

RYR1 RYR2 RYR3

5.69e-096163CID000129958
DrugAC1O528X

RYR1 RYR2 RYR3

5.69e-096163CID006475857
Drugchloro-m-cresol

RYR1 RYR2 RYR3

5.69e-096163CID000012008
DrugAzumoleno

RYR1 RYR2 RYR3

9.95e-097163CID000056259
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

RYR1 RYR2 RYR3

9.95e-097163CID009547999
DrugBr2BAPTA

RYR1 RYR2 RYR3

9.95e-097163CID003081001
DrugPCB 95

RYR1 RYR2 RYR3

3.41e-0810163CID000038012
DrugPCB 66

RYR1 RYR2 RYR3

4.68e-0811163CID000036185
DrugR 478

RYR1 RYR2 RYR3

4.68e-0811163CID000084223
Drug8-amino-cADPR

RYR1 RYR2 RYR3

4.68e-0811163CID003081323
DrugRyanodine

RYR1 RYR2 RYR3

6.24e-0812163ctd:D012433
DrugFPL 64176

RYR1 RYR2 RYR3

1.29e-0715163CID000003423
DrugGvapspat amide

RYR1 RYR2 RYR3

1.29e-0715163CID000125015
Drugkazinol B

RYR1 RYR2 RYR3

1.92e-0717163CID000480869
Drugmethylcoumarin

RYR1 RYR2 RYR3

2.31e-0718163CID000007092
DrugAC1L380G

RYR1 RYR2 RYR3

2.74e-0719163CID000084698
DrugAC1MW7VF

RYR1 RYR2 RYR3

2.74e-0719163CID000414699
Drugindo-1/AM

RYR1 RYR2 RYR3

3.76e-0721163CID000123918
Drug5'-adenylyl (beta,gamma-methylene)diphosphonate

RYR1 RYR3

4.63e-072162ctd:C005147
DrugT0702

RYR1 RYR2 RYR3

6.49e-0725163CID000005908
Drug2,4-xylidinothiazoline

RYR1 RYR2 RYR3

1.14e-0630163CID000099296
DrugLOPAC

RYR1 RYR2 RYR3

1.14e-0630163CID000062696
DrugM-HN

RYR1 RYR2 RYR3

1.26e-0631163CID000015450
Drug1,1'-diheptyl-4,4'-bipyridinium

RYR1 RYR3

1.39e-063162CID000080262
Drugflubendiamide

RYR1 RYR3

1.39e-063162CID011193251
DrugM3/M4

RYR1 RYR2 RYR3

1.39e-0632163CID000486507
DrugIHC-64

RYR1 RYR2 RYR3

1.53e-0633163CID000162753
DrugCNS 1145

RYR1 RYR2 RYR3

1.53e-0633163CID000190902
DrugAC1L1IZE

RYR1 RYR2 RYR3 DNAH17

1.81e-06131164CID000004799
Drugmag-fura-2

RYR1 RYR2 RYR3

2.18e-0637163CID000123839
Drug1,2-dichlorohexafluorocyclobutane

RYR1 RYR2 RYR3

2.18e-0637163CID000009643
Drug4-chloro-m-cresol

RYR1 RYR2 RYR3

2.18e-0637163CID000001732
DrugAC1L98DX

RYR1 RYR2 RYR3

2.37e-0638163CID000439957
DrugNAADP

RYR1 RYR2 RYR3

2.56e-0639163CID000123952
Drugdipyrone

RYR1 RYR2 RYR3

2.77e-0640163CID000003110
DrugA-30

RYR1 RYR3

2.78e-064162CID003028528
DrugBastadin 10

RYR1 RYR3

2.78e-064162CID009589366
DrugDantrolene

RYR1 RYR2 RYR3

2.99e-0641163ctd:D003620
Druglead compounds

RYR1 RYR2 RYR3 FBN2

3.10e-06150164CID000073212
Drugisocitrate

RYR1 RYR2 RYR3 FBN2

3.62e-06156164CID000001198
Drugescina

RYR1 RYR2 RYR3

3.71e-0644163CID006433489
Drug4,4'-dithiodipyridine

RYR1 RYR2 RYR3

3.97e-0645163CID000075846
DrugA 68930

RYR1 RYR2

4.62e-065162ctd:C065380
Drugts M

RYR1 RYR2 RYR3

4.83e-0648163CID000428025
DrugTrp-Trp

RYR1 RYR2 RYR3

5.14e-0649163CID000088656
DrugAC1L9KQO

RYR1 RYR2 RYR3

5.14e-0649163CID000447335
Drugetridiazole

RYR1 RYR2 RYR3

5.47e-0650163CID000017432
DrugNSC692750

RYR1 RYR3

6.93e-066162CID000078910
DrugCinildipine

RYR1 RYR2 RYR3

7.72e-0656163CID000002752
Drugcysteinylglycine

RYR1 RYR2 RYR3

8.14e-0657163CID000065270
DrugNSC3260

RYR1 RYR2 RYR3 FBN2

8.76e-06195164CID000220461
Drugnilvadipine

RYR1 RYR2 RYR3

9.51e-0660163CID000004494
Drugmag-indo-1

RYR1 RYR3

9.70e-067162CID000131881
DrugCHEBI:564108

RYR1 RYR3

9.70e-067162CID006400637
DrugIAA-94

RYR1 RYR2 RYR3

1.00e-0561163CID000003667
Druglercanidipine

RYR1 RYR2 RYR3

1.10e-0563163CID000065866
Drugsuccinylcholine

RYR1 RYR2 RYR3

1.16e-0564163CID000005314
Drugfura 2

RYR1 RYR2 RYR3

1.21e-0565163CID000057054
Druggallopamil

RYR1 RYR2 RYR3

1.33e-0567163CID000001234
Drugstrontium

RYR1 RYR2 RYR3

1.39e-0568163CID000104798
DrugtBuBHQ

RYR1 RYR2 RYR3

1.45e-0569163CID000002374
DrugAC1L2AC7

RYR1 RYR2 RYR3

1.45e-0569163CID000068733
Drugflecainide

RYR1 RYR2 RYR3

1.58e-0571163CID000003355
DrugAC1L1D8L

RYR1 RYR2 RYR3

1.58e-0571163CID000002241
DrugFLA 365

RYR1 RYR3

1.66e-059162CID000072776
Druglactosyl lysosphingolipid

RYR1 RYR3

1.66e-059162CID006439268
DrugCAS 298-57-7

RYR1 RYR2 RYR3

1.72e-0573163CID000002761
Drugethosuximide

RYR1 RYR2 RYR3

1.79e-0574163CID000003291
DrugAC1N38XE

RYR1 RYR3

2.08e-0510162CID004060965
Drugnisoldipine

RYR1 RYR2 RYR3

2.10e-0578163CID000004499
DrugFura-2AM

RYR1 RYR2 RYR3

2.18e-0579163CID000105091
DrugN-cyclopentyl-N-cyclobutylformamide

RYR1 RYR2 RYR3

2.18e-0579163CID005287890
DrugcADPR

RYR1 RYR2 RYR3

2.44e-0582163CID000123847
Drug2,3,6,2',3',6'-hexachlorobiphenyl

RYR1 RYR2

2.54e-0511162ctd:C010498
Drugtectoridin

RYR1 RYR2

2.54e-0511162CID005281810
DrugXeC compound

RYR1 RYR2 RYR3

2.62e-0584163CID000005701
Drugeuropium

RYR1 RYR2 RYR3

2.91e-0587163CID000023981
Drugtetracaine

RYR1 RYR2 RYR3

3.01e-0588163CID000005411
Drugadenosine diphosphoribose

RYR1 RYR2 RYR3

3.44e-0592163CID000030243
DrugNSC299933

RYR1 RYR3

3.60e-0513162CID000431902
Drugruthenium

RYR1 RYR2 RYR3

3.67e-0594163CID000023950
Drugmanidipine

RYR1 RYR2 RYR3

3.79e-0595163CID000004008
Drugisotetrandrine

RYR1 RYR2 RYR3

4.03e-0597163CID000005422
Drugborate

RYR1 RYR2 RYR3

4.16e-0598163CID000007628
Drugnitrendipine

RYR1 RYR2 RYR3

4.16e-0598163CID000004507
Drugbimoclomol

RYR1 RYR3

4.19e-0514162CID009576891
DrugNP-EGTA

RYR1 RYR3

4.19e-0514162CID000183793
Drugindo-1

RYR1 RYR2 RYR3

4.29e-0599163CID000105060
Drugisradipine

RYR1 RYR2 RYR3

4.42e-05100163CID000003784
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR1 RYR2 RYR3

1.31e-103163DOID:8545 (implicated_via_orthology)
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR1 RYR2 RYR3

1.31e-103163DOID:3529 (implicated_via_orthology)
Diseasealcohol use disorder (implicated_via_orthology)

PHF10 RYR1 RYR2 RYR3

3.16e-06195164DOID:1574 (implicated_via_orthology)
Diseasepulmonary hypertension (biomarker_via_orthology)

RYR1 RYR2 RYR3

1.05e-0580163DOID:6432 (biomarker_via_orthology)
Diseasesusceptibility to rheumatic fever measurement

CSGALNACT1 RYR3

1.03e-0428162EFO_0008416
Diseaseacute lymphoblastic leukemia

CSGALNACT1 RYR2

5.79e-0466162EFO_0000220
DiseaseIntellectual Disability

OXR1 ZC3H14 KMT2C

1.67e-03447163C3714756
Diseaseascending aortic diameter

RYR2 FBN2

2.57e-03140162EFO_0021787

Protein segments in the cluster

PeptideGeneStartEntry
CMDELTPEQYKMCMQ

CSGALNACT1

481

Q8TDX6
FSKFSLDCPSCDMME

CCAR1

366

Q8IX12
MKETFCMSSMKCYRS

GPR19

341

Q15760
AQCMFFKDKTMLCPM

KMT2C

4491

Q8NEZ4
CEEYGIMCPMEEVMS

OXR1

256

Q8N573
EEMMFCDMCDRGYHT

PHF10

446

Q8WUB8
MCTKEMEFKCMLFAL

DNAH17

4016

Q9UFH2
DMLCALMCPMHDDYD

DNAJC13

476

O75165
YDGFMASMDMKTCID

FBN2

1311

P35556
LYSLPKLTCMCCMFM

BTBD9

151

Q96Q07
DEPDMKCDDMMTCYL

RYR1

4871

P21817
KCDDMMTCYLFHMYV

RYR1

4876

P21817
TPDMKCDDMLTCYMF

RYR2

4801

Q92736
AEMPLFKLYMVMSAC

GPR108

256

Q9NPR9
DMKCDDMMTCYLFHM

RYR3

4706

Q15413
MEGDCLSCMKYLMFV

TSPAN18

1

Q96SJ8
YMSDQEEDMCFEGMK

ZC3H14

531

Q6PJT7