Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	2.81e-07	55	51	5	GO:0042974
GeneOntologyMolecularFunction	nuclear receptor binding	PRAMEF7 PRAMEF33 PRAMEF10 MED16 ESR1 PRAMEF17 PRAMEF8	4.62e-07	187	51	7	GO:0016922
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	2.09e-06	82	51	5	GO:1990756
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	4.33e-06	95	51	5	GO:0140767
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	PRAMEF7 PRAMEF33 PRAMEF10 MED16 ESR1 PDCD11 PRAMEF17 PRAMEF8	9.81e-06	417	51	8	GO:0061629
GeneOntologyMolecularFunction	type III transforming growth factor beta receptor binding	TGFB1 TGFB2	3.82e-05	4	51	2	GO:0034714
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	PRAMEF7 PRAMEF33 PRAMEF10 MED16 ESR1 PDCD11 PRAMEF17 PRAMEF8	1.05e-04	582	51	8	GO:0140297
GeneOntologyMolecularFunction	epoxide hydrolase activity	EPHX4 ALOX12	3.47e-04	11	51	2	GO:0004301
GeneOntologyMolecularFunction	type II transforming growth factor beta receptor binding	TGFB1 TGFB2	4.15e-04	12	51	2	GO:0005114
GeneOntologyMolecularFunction	hydrolase activity, acting on ether bonds	EPHX4 ALOX12	4.90e-04	13	51	2	GO:0016801
GeneOntologyMolecularFunction	ether hydrolase activity	EPHX4 ALOX12	4.90e-04	13	51	2	GO:0016803
GeneOntologyMolecularFunction	transcription factor binding	PRAMEF7 PRAMEF33 PRAMEF10 MED16 ESR1 PDCD11 PRAMEF17 PRAMEF8	5.97e-04	753	51	8	GO:0008134
GeneOntologyMolecularFunction	transforming growth factor beta receptor binding	TGFB1 TGFB2	2.84e-03	31	51	2	GO:0005160
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DOCK1 ARHGEF39 FARP1 ALS2CL	2.85e-03	231	51	4	GO:0005085
GeneOntologyBiologicalProcess	regulation of ERK1 and ERK2 cascade	TGFB1 PRAMEF7 PRAMEF10 ESR1 C3 PRAMEF17 PRAMEF8	3.74e-05	385	50	7	GO:0070372
GeneOntologyBiologicalProcess	blastocyst formation	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	3.82e-05	78	50	4	GO:0001825
GeneOntologyBiologicalProcess	ERK1 and ERK2 cascade	TGFB1 PRAMEF7 PRAMEF10 ESR1 C3 PRAMEF17 PRAMEF8	6.29e-05	418	50	7	GO:0070371
GeneOntologyBiologicalProcess	regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	TGFB1 TGFB2	8.59e-05	6	50	2	GO:1905005
GeneOntologyBiologicalProcess	branch elongation involved in mammary gland duct branching	TGFB1 ESR1	8.59e-05	6	50	2	GO:0060751
GeneOntologyBiologicalProcess	oocyte development	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	9.71e-05	99	50	4	GO:0048599
GeneOntologyBiologicalProcess	oocyte differentiation	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.13e-04	103	50	4	GO:0009994
GeneOntologyBiologicalProcess	somatic stem cell population maintenance	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.36e-04	108	50	4	GO:0035019
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	1.00e-07	47	51	5	GO:0031462
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	1.65e-04	212	51	5	GO:0031461
GeneOntologyCellularComponent	secretory granule	TGFB1 TGFB2 PRAMEF7 PRAMEF10 STXBP5 TCIRG1 C3 PRAMEF17 PRAMEF8	6.94e-04	1014	51	9	GO:0030141
MousePheno	abnormal jejunum morphology	PRAMEF7 LIPA PRAMEF10 PRAMEF17 PRAMEF8	1.32e-07	41	42	5	MP:0004002
MousePheno	abnormal spermatogonia proliferation	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	2.68e-07	47	42	5	MP:0002685
MousePheno	abnormal duodenum morphology	PRAMEF7 LIPA PRAMEF10 PRAMEF17 PRAMEF8	1.28e-06	64	42	5	MP:0003271
MousePheno	increased kidney weight	PRAMEF7 PRAMEF33 PRAMEF10 TCIRG1 PRAMEF17 PRAMEF8	4.33e-06	145	42	6	MP:0003917
MousePheno	abnormal cecum morphology	SEMA6C PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.11e-05	99	42	5	MP:0000494
MousePheno	abnormal small intestine morphology	TGFB2 PRAMEF7 LIPA PRAMEF10 PRAMEF17 PRAMEF8	1.86e-05	187	42	6	MP:0000496
MousePheno	abnormal kidney morphology	TGFB1 DOCK1 TGFB2 PRAMEF7 PRAMEF33 LIPA PRAMEF10 STXBP5 ESR1 TCIRG1 C3 PRAMEF17 PRAMEF8 KYNU	2.52e-05	1363	42	14	MP:0002135
MousePheno	increased circulating amylase level	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	2.72e-05	119	42	5	MP:0008806
MousePheno	abnormal intestine morphology	TGFB1 TGFB2 SEMA6C PRAMEF7 LIPA PRAMEF10 C3 PRAMEF17 PRAMEF8	2.79e-05	546	42	9	MP:0000477
MousePheno	abnormal kidney weight	PRAMEF7 PRAMEF33 PRAMEF10 TCIRG1 PRAMEF17 PRAMEF8	3.39e-05	208	42	6	MP:0002707
MousePheno	abnormal sperm number	TGFB2 PRAMEF7 PRAMEF33 PRAMEF10 NPEPPS ESR1 PRAMEF17 PRAMEF8 TDRD12	7.88e-05	624	42	9	MP:0002673
MousePheno	azoospermia	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8 TDRD12	8.24e-05	244	42	6	MP:0005159
MousePheno	decreased male germ cell number	TGFB2 PRAMEF7 PRAMEF33 PRAMEF10 NPEPPS ESR1 PRAMEF17 PRAMEF8 TDRD12	9.58e-05	640	42	9	MP:0004901
MousePheno	abnormal circulating amylase level	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	9.89e-05	156	42	5	MP:0008804
MousePheno	decreased testis weight	PRAMEF7 PRAMEF33 PRAMEF10 ESR1 PRAMEF17 PRAMEF8 TDRD12	1.04e-04	370	42	7	MP:0004852
MousePheno	absent gametes	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8 TDRD12	1.07e-04	256	42	6	MP:0001117
MousePheno	abnormal testis weight	PRAMEF7 PRAMEF33 PRAMEF10 ESR1 PRAMEF17 PRAMEF8 TDRD12	1.47e-04	391	42	7	MP:0004850
MousePheno	abnormal large intestine morphology	TGFB1 SEMA6C PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.62e-04	276	42	6	MP:0000489
MousePheno	decreased germ cell number	TGFB2 PRAMEF7 PRAMEF33 PRAMEF10 NPEPPS ESR1 PRAMEF17 PRAMEF8 TDRD12	1.64e-04	687	42	9	MP:0002209
MousePheno	increased circulating alanine transaminase level	TGFB1 PRAMEF7 PRAMEF10 C3 PRAMEF17 PRAMEF8 ALS2CL	2.03e-04	412	42	7	MP:0002941
MousePheno	increased male germ cell apoptosis	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	2.43e-04	189	42	5	MP:0014052
MousePheno	abnormal vitreous body morphology	TGFB2 PRAMEF7 PRAMEF33 PRAMEF10 FARP1 PRAMEF17 PRAMEF8	2.60e-04	429	42	7	MP:0002699
MousePheno	abnormal auditory brainstem response	CCN5 PRAMEF7 PRAMEF33 PRAMEF10 ESPNL PRAMEF17 USP39 PRAMEF8	2.70e-04	576	42	8	MP:0004738
MousePheno	abnormal testis size	TGFB2 PRAMEF7 PRAMEF33 PRAMEF10 NPEPPS ESR1 PRAMEF17 PRAMEF8 PLPP6 TDRD12	2.95e-04	915	42	10	MP:0004849
MousePheno	abnormal hearing electrophysiology	CCN5 PRAMEF7 PRAMEF33 PRAMEF10 ESPNL PRAMEF17 USP39 PRAMEF8	3.33e-04	594	42	8	MP:0006335
MousePheno	clubfoot	TCIRG1 KYNU	3.91e-04	10	42	2	MP:0000576
MousePheno	enlarged urinary bladder	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	3.95e-04	116	42	4	MP:0011874
MousePheno	abnormal gametes	TGFB2 PRAMEF7 PRAMEF33 PRAMEF10 NPEPPS ESR1 PRAMEF17 PRAMEF8 TDRD12	4.43e-04	785	42	9	MP:0001124
MousePheno	abnormal hearing physiology	CCN5 PRAMEF7 PRAMEF33 PRAMEF10 ESPNL PRAMEF17 USP39 PRAMEF8	5.65e-04	643	42	8	MP:0001963
MousePheno	enlarged kidney	PRAMEF7 PRAMEF33 PRAMEF10 TCIRG1 PRAMEF17 PRAMEF8	6.14e-04	354	42	6	MP:0003068
MousePheno	small testis	TGFB2 PRAMEF7 PRAMEF33 PRAMEF10 NPEPPS ESR1 PRAMEF17 PRAMEF8 TDRD12	6.25e-04	823	42	9	MP:0001147
MousePheno	cataract	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 ADAMTS14 PRAMEF8 KYNU	6.30e-04	497	42	7	MP:0001304
MousePheno	abnormal circulating alanine transaminase level	TGFB1 PRAMEF7 PRAMEF10 C3 PRAMEF17 PRAMEF8 ALS2CL	6.38e-04	498	42	7	MP:0001573
MousePheno	abnormal male germ cell apoptosis	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	6.72e-04	236	42	5	MP:0008280
MousePheno	decreased exploration in new environment	PRAMEF7 PRAMEF10 STXBP5 TMEM59 PRAMEF17 PRAMEF8 KYNU	7.34e-04	510	42	7	MP:0001417
MousePheno	abnormal male germ cell physiology	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	7.81e-04	244	42	5	MP:0020362
MousePheno	abnormal lymph node morphology	TGFB1 PRAMEF7 LIPA PRAMEF10 ESR1 TCIRG1 PRAMEF17 PRAMEF8	8.40e-04	683	42	8	MP:0002339
MousePheno	abnormal stomach morphology	TGFB1 PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	8.40e-04	248	42	5	MP:0000470
MousePheno	abnormal ear physiology	CCN5 PRAMEF7 PRAMEF33 PRAMEF10 ESPNL PRAMEF17 USP39 PRAMEF8	8.48e-04	684	42	8	MP:0003878
MousePheno	abnormal male germ cell morphology	TGFB2 PRAMEF7 PRAMEF33 PRAMEF10 NPEPPS ESR1 PRAMEF17 PRAMEF8 TDRD12	8.50e-04	859	42	9	MP:0006362
MousePheno	thick mitral valve	DOCK1 TGFB2	9.03e-04	15	42	2	MP:0010620
MousePheno	reduced male mating frequency	NPEPPS ESR1	9.03e-04	15	42	2	MP:0001380
MousePheno	abnormal lens morphology	TGFB2 PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 ADAMTS14 PRAMEF8 KYNU	9.77e-04	699	42	8	MP:0001303
MousePheno	small gonad	TGFB2 PRAMEF7 PRAMEF33 PRAMEF10 NPEPPS ESR1 PRAMEF17 PRAMEF8 TDRD12	1.05e-03	885	42	9	MP:0001116
MousePheno	abnormal testis morphology	TGFB2 PRAMEF7 PRAMEF33 PRAMEF10 NPEPPS ESR1 PRAMEF17 PRAMEF8 PLPP6 TDRD12	1.10e-03	1081	42	10	MP:0001146
MousePheno	abnormal germ cell physiology	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	1.17e-03	267	42	5	MP:0020363
MousePheno	abnormal primary sex determination	TGFB2 PRAMEF7 PRAMEF33 PRAMEF10 NPEPPS ESR1 PRAMEF17 PRAMEF8 TDRD12	1.19e-03	901	42	9	MP:0002211
MousePheno	hearing/vestibular/ear phenotype	TGFB2 CCN5 PRAMEF7 PRAMEF33 PRAMEF10 ESPNL PRAMEF17 USP39 PRAMEF8	1.23e-03	905	42	9	MP:0005377
MousePheno	abnormal spermatogenesis	TGFB2 PRAMEF7 PRAMEF33 PRAMEF10 NPEPPS ESR1 PRAMEF17 PRAMEF8 TDRD12	1.28e-03	910	42	9	MP:0001156
MousePheno	thick atrioventricular valve	DOCK1 TGFB2	1.31e-03	18	42	2	MP:0031574
Domain	PRAME_family	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.85e-07	19	51	4	IPR026271
Domain	TGF-beta	TGFB1 TGFB2	2.19e-05	3	51	2	IPR016319
Domain	TSP_1	CCN5 ADAMTS17 ADAMTS14	6.79e-04	63	51	3	PF00090
Domain	TSP1	CCN5 ADAMTS17 ADAMTS14	7.44e-04	65	51	3	SM00209
Domain	TSP1_rpt	CCN5 ADAMTS17 ADAMTS14	7.44e-04	65	51	3	IPR000884
Domain	TSP1	CCN5 ADAMTS17 ADAMTS14	7.44e-04	65	51	3	PS50092
Domain	DH-domain	ARHGEF39 FARP1 ALS2CL	9.62e-04	71	51	3	IPR000219
Domain	-	ARHGEF39 FARP1 ALS2CL	9.62e-04	71	51	3	1.20.900.10
Domain	PLAC	ADAMTS17 ADAMTS14	1.21e-03	19	51	2	IPR010909
Domain	PLAC	ADAMTS17 ADAMTS14	1.21e-03	19	51	2	PS50900
Domain	ADAM_spacer1	ADAMTS17 ADAMTS14	1.78e-03	23	51	2	IPR010294
Domain	ADAM_spacer1	ADAMTS17 ADAMTS14	1.78e-03	23	51	2	PF05986
Domain	-	PRAMEF7 LRRC3C PRAMEF10 PRAMEF17 PRAMEF8	1.79e-03	321	51	5	3.80.10.10
Domain	Peptidase_M12B_ADAM-TS	ADAMTS17 ADAMTS14	1.94e-03	24	51	2	IPR013273
Domain	L_dom-like	PRAMEF7 LRRC3C PRAMEF10 PRAMEF17 PRAMEF8	1.96e-03	328	51	5	IPR032675
Domain	ZINC_PROTEASE	NPEPPS ADAMTS17 ADAMTS14	2.43e-03	98	51	3	PS00142
Domain	ADAM_Cys-rich	ADAMTS17 ADAMTS14	2.46e-03	27	51	2	IPR006586
Domain	ACR	ADAMTS17 ADAMTS14	2.46e-03	27	51	2	SM00608
Domain	TGFb_propeptide	TGFB1 TGFB2	2.64e-03	28	51	2	PF00688
Domain	TGF-b_N	TGFB1 TGFB2	2.64e-03	28	51	2	IPR001111
Domain	Abhydrolase_1	LIPA EPHX4	3.23e-03	31	51	2	PF00561
Domain	TGF-beta-rel	TGFB1 TGFB2	3.44e-03	32	51	2	IPR015615
Domain	TGFb_CS	TGFB1 TGFB2	3.44e-03	32	51	2	IPR017948
Domain	AB_hydrolase_1	LIPA EPHX4	3.66e-03	33	51	2	IPR000073
Domain	TGFB	TGFB1 TGFB2	4.58e-03	37	51	2	SM00204
Domain	TGF_BETA_2	TGFB1 TGFB2	4.58e-03	37	51	2	PS51362
Domain	TGF_beta	TGFB1 TGFB2	4.58e-03	37	51	2	PF00019
Domain	TGF-b_C	TGFB1 TGFB2	4.58e-03	37	51	2	IPR001839
Domain	TGF_BETA_1	TGFB1 TGFB2	4.58e-03	37	51	2	PS00250
Domain	Peptidase_M12B_N	ADAMTS17 ADAMTS14	5.08e-03	39	51	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS17 ADAMTS14	5.08e-03	39	51	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS17 ADAMTS14	5.34e-03	40	51	2	PS00427
Domain	ADAM_MEPRO	ADAMTS17 ADAMTS14	5.34e-03	40	51	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS17 ADAMTS14	5.34e-03	40	51	2	PS50214
Domain	Reprolysin	ADAMTS17 ADAMTS14	5.34e-03	40	51	2	PF01421
Domain	Peptidase_M12B	ADAMTS17 ADAMTS14	5.34e-03	40	51	2	IPR001590
Domain	CYSTEINE_SWITCH	ADAMTS17 ADAMTS14	5.60e-03	41	51	2	PS00546
Domain	Disintegrin_dom	ADAMTS17 ADAMTS14	5.60e-03	41	51	2	IPR001762
Domain	Pept_M10_metallopeptidase	ADAMTS17 ADAMTS14	6.15e-03	43	51	2	IPR001818
Domain	Quinoprotein_ADH-like_supfam	SEMA6C WDR87	9.22e-03	53	51	2	IPR011047
Domain	DH_1	ARHGEF39 FARP1	1.28e-02	63	51	2	PS00741
Domain	-	SEMA6C MED16 STXBP5 WDR87	1.28e-02	333	51	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SEMA6C MED16 STXBP5 WDR87	1.31e-02	335	51	4	IPR015943
Pathway	REACTOME_TGFBR3_REGULATES_TGF_BETA_SIGNALING	TGFB1 TGFB2	1.66e-04	8	35	2	M48252
Pathway	REACTOME_TGFBR3_REGULATES_TGF_BETA_SIGNALING	TGFB1 TGFB2	1.66e-04	8	35	2	MM17233
Pathway	KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY	TGFB1 TGFB2	1.66e-04	8	35	2	M47415
Pathway	KEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA	TGFB1 TGFB2	1.66e-04	8	35	2	M47850
Pathway	KEGG_MEDICUS_REFERENCE_HIF_1_SIGNALING_PATHWAY	TGFB1 TGFB2	2.13e-04	9	35	2	M47421
Pathway	KEGG_MEDICUS_VARIANT_LOSS_OF_VHL_TO_HIF_1_SIGNALING_PATHWAY	TGFB1 TGFB2	5.35e-04	14	35	2	M47422
Pathway	SA_MMP_CYTOKINE_CONNECTION	TGFB1 TGFB2	6.16e-04	15	35	2	M11736
Pathway	BIOCARTA_ERYTH_PATHWAY	TGFB1 TGFB2	6.16e-04	15	35	2	M9367
Pathway	KEGG_LEISHMANIA_INFECTION	TGFB1 TGFB2 C3	7.44e-04	72	35	3	M3126
Pathway	BIOCARTA_TGFB_PATHWAY	TGFB1 TGFB2	7.96e-04	17	35	2	MM1509
Pathway	WP_PLATELETMEDIATED_INTERACTIONS_WITH_VASCULAR_AND_CIRCULATING_CELLS	TGFB1 TGFB2	7.96e-04	17	35	2	M39807
Pathway	BIOCARTA_ERYTH_PATHWAY	TGFB1 TGFB2	8.94e-04	18	35	2	MM1392
Pathway	BIOCARTA_TGFB_PATHWAY	TGFB1 TGFB2	9.97e-04	19	35	2	M18933
Pathway	BIOCARTA_TOB1_PATHWAY	TGFB1 TGFB2	9.97e-04	19	35	2	M18215
Pathway	BIOCARTA_TOB1_PATHWAY	TGFB1 TGFB2	9.97e-04	19	35	2	MM1490
Pathway	REACTOME_SIGNALING_BY_TGFBR3	TGFB1 TGFB2	1.22e-03	21	35	2	MM17231
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	1.03e-10	20	53	5	26694250
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	1.75e-10	22	53	5	31729367
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	3.51e-10	25	53	5	37451217
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	6.48e-10	28	53	5	25089626
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	9.37e-10	30	53	5	38786026
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	2.12e-09	35	53	5	19389355
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.13e-08	17	53	4	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.13e-08	17	53	4	37781892
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	1.36e-08	50	53	5	31806660
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.45e-08	18	53	4	23894331
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.45e-08	18	53	4	39181896
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.45e-08	18	53	4	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.45e-08	18	53	4	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.45e-08	18	53	4	14675769
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.83e-08	19	53	4	28604677
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	2.29e-08	20	53	4	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	2.29e-08	20	53	4	21425410
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	4.16e-08	23	53	4	19480014
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	5.94e-08	25	53	4	12620990
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	7.01e-08	26	53	4	18500982
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.67e-07	32	53	4	37889087
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	PRAMEF7 PRAMEF33 PRAMEF10 FARP1 ESR1 PRAMEF17 PRAMEF8	6.35e-07	326	53	7	17015433
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	7.48e-07	46	53	4	17287250
Pubmed	A multilocus candidate approach identifies ACE and HIF1A as susceptibility genes for cellulite.	TGFB1 TGFB2 ESR1	1.50e-06	15	53	3	20059631
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.92e-06	58	53	4	31598710
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	2.06e-06	59	53	4	11279525
Pubmed	A missense TGFB2 variant p.(Arg320Cys) causes a paradoxical and striking increase in aortic TGFB1/2 expression.	TGFB1 TGFB2	2.28e-06	2	53	2	27782106
Pubmed	Transforming growth factor-beta in the early mouse embryo: implications for the regulation of muscle formation and implantation.	TGFB1 TGFB2	2.28e-06	2	53	2	8358866
Pubmed	Endothelium-dependent epithelial-mesenchymal transition of tumor cells: exclusive roles of transforming growth factor β1 and β2.	TGFB1 TGFB2	2.28e-06	2	53	2	23668958
Pubmed	Cancer-associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-β-dependent pathways in genotype-specific oral cancer.	TGFB1 TGFB2	2.28e-06	2	53	2	27803052
Pubmed	TGF-β1 stimulates movement of renal proximal tubular epithelial cells in a three-dimensional cell culture via an autocrine TGF-β2 production.	TGFB1 TGFB2	2.28e-06	2	53	2	27880866
Pubmed	TGF beta1 and TGF beta2 and their role in posthemorrhagic hydrocephalus following SAH and IVH.	TGFB1 TGFB2	2.28e-06	2	53	2	23690072
Pubmed	Tgf-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma.	TGFB1 TGFB2	2.28e-06	2	53	2	20300191
Pubmed	Elevated TGF-β1 and -β2 expression accelerates the epithelial to mesenchymal transition in triple-negative breast cancer cells.	TGFB1 TGFB2	2.28e-06	2	53	2	26088755
Pubmed	Expression of estrogen receptor α and growth factors in human prolactinoma and its correlation with clinical features and gender.	TGFB1 ESR1	2.28e-06	2	53	2	21422801
Pubmed	Cardiomyopathy in young adults with classic mitral valve prolapse.	TGFB1 TGFB2	2.28e-06	2	53	2	23880103
Pubmed	Variations in transforming growth factor beta in human milk are not related to levels in plasma.	TGFB1 TGFB2	2.28e-06	2	53	2	11991670
Pubmed	Strain-dependent effects of transforming growth factor-β1 and 2 during mouse secondary palate development.	TGFB1 TGFB2	2.28e-06	2	53	2	25450421
Pubmed	HIV-1 infection and HIV-1 Tat protein permit the survival and replication of a non-pathogenic trypanosomatid in macrophages through TGF-beta1 production.	TGFB1 TGFB2	2.28e-06	2	53	2	18457978
Pubmed	Primary and immortalized mouse epicardial cells undergo differentiation in response to TGFbeta.	TGFB1 TGFB2	2.28e-06	2	53	2	18213583
Pubmed	Mast cells are a source of transforming growth factor β in systemic sclerosis.	TGFB1 TGFB2	2.28e-06	2	53	2	21360509
Pubmed	TGF-β1 and TGF-β2 abundance in liver diseases of mice and men.	TGFB1 TGFB2	2.28e-06	2	53	2	26799667
Pubmed	The effects of retinoid status on TGF beta expression during mouse embryogenesis.	TGFB1 TGFB2	2.28e-06	2	53	2	7485998
Pubmed	ERα prevents tumorigenesis of both liver and breast cancer cells through CCN5.	CCN5 ESR1	2.28e-06	2	53	2	37343316
Pubmed	Role of transforming growth factor-beta in breast milk for initiation of IgA production in newborn infants.	TGFB1 TGFB2	2.28e-06	2	53	2	15113633
Pubmed	The prognosis significance of TGF-β1 and ER protein in cervical adenocarcinoma patients with stage Ib~IIa.	TGFB1 ESR1	2.28e-06	2	53	2	25113249
Pubmed	Transforming growth factor-beta(2) polymorphisms are associated with childhood atopic asthma.	TGFB1 TGFB2	2.28e-06	2	53	2	17651146
Pubmed	Mediator complex subunit 16 is down-regulated in papillary thyroid cancer, leading to increased transforming growth factor-β signaling and radioiodine resistance.	TGFB1 MED16	2.28e-06	2	53	2	32532820
Pubmed	Activation of Smad-mediated TGF-β signaling triggers epithelial-mesenchymal transitions in murine cloned corneal progenitor cells.	TGFB1 TGFB2	2.28e-06	2	53	2	22674610
Pubmed	Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-β1 and TGF-β2-dependent pathway.	TGFB1 TGFB2	2.28e-06	2	53	2	25068653
Pubmed	Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice.	TGFB1 TGFB2	2.28e-06	2	53	2	7774812
Pubmed	Is transforming growth factor-β signaling activated in human hypertrophied prostate treated by 5-alpha reductase inhibitor?	TGFB1 TGFB2	2.28e-06	2	53	2	24311892
Pubmed	Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-β Signaling in the Retinal Pigment Epithelium.	TGFB1 C3	2.28e-06	2	53	2	25802332
Pubmed	TGF-beta1 and TGF-beta2 expression after traumatic human spinal cord injury.	TGFB1 TGFB2	2.28e-06	2	53	2	18040277
Pubmed	Differential effect of hypoxia on early endothelial-mesenchymal transition response to transforming growth beta isoforms 1 and 2.	TGFB1 TGFB2	2.28e-06	2	53	2	27503671
Pubmed	Regulation of bovine corneal endothelial cell cycle by transforming growth factor-beta.	TGFB1 TGFB2	2.28e-06	2	53	2	14510802
Pubmed	Transforming growth factor-β gene silencing using adenovirus expressing TGF-β1 or TGF-β2 shRNA.	TGFB1 TGFB2	2.28e-06	2	53	2	23306609
Pubmed	Microarray-based estimation of SNP allele-frequency in pooled DNA using the Langmuir kinetic model.	TGFB1 ESR1	6.83e-06	3	53	2	19087310
Pubmed	Studies of TGF-beta(1-3) in serosal fluid during abdominal surgery and their effect on in vitro human mesothelial cell proliferation.	TGFB1 TGFB2	6.83e-06	3	53	2	19062040
Pubmed	Activity-dependent release of transforming growth factor-beta in a neuronal network in vitro.	TGFB1 TGFB2	6.83e-06	3	53	2	17997227
Pubmed	PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells.	TGFB1 TGFB2	6.83e-06	3	53	2	19572226
Pubmed	Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression.	TGFB1 TGFB2	6.83e-06	3	53	2	17999987
Pubmed	Oestrogen receptor alpha genotype, and interactions between vitamin D receptor and transforming growth factor-beta1 genotypes are associated with quantitative calcaneal ultrasound in postmenopausal women.	TGFB1 ESR1	6.83e-06	3	53	2	14725686
Pubmed	TGF-beta knockout and dominant-negative receptor transgenic mice.	TGFB1 TGFB2	6.83e-06	3	53	2	9525700
Pubmed	Binding of transforming growth factor-beta (TGF-beta) to pregnancy zone protein (PZP). Comparison to the TGF-beta-alpha 2-macroglobulin interaction.	TGFB1 TGFB2	6.83e-06	3	53	2	7513640
Pubmed	Differential expression of transforming growth factor-beta isoforms in bullous keratopathy corneas.	TGFB1 TGFB2	6.83e-06	3	53	2	20142847
Pubmed	Posttraumatic temporal TGF-β mRNA expression in lens epithelial cells of paediatric patients.	TGFB1 TGFB2	6.83e-06	3	53	2	22464821
Pubmed	Expression of transforming growth factor-beta 1, -beta 2, and -beta 3 in human developing teeth: immunolocalization according to the odontogenesis phases.	TGFB1 TGFB2	6.83e-06	3	53	2	18078367
Pubmed	Leptin-induced ER-α-positive breast cancer cell viability and migration is mediated by suppressing CCN5-signaling via activating JAK/AKT/STAT-pathway.	CCN5 ESR1	6.83e-06	3	53	2	29370782
Pubmed	Excess TGF-β mediates muscle weakness associated with bone metastases in mice.	TGFB1 TGFB2	6.83e-06	3	53	2	26457758
Pubmed	Changes in expression of genes related to cell proliferation in human mesenchymal stem cells during in vitro culture in comparison with cancer cells.	TGFB1 TGFB2	6.83e-06	3	53	2	16998703
Pubmed	Specific transforming growth factor-beta subtypes regulate embryonic mouse Meckel's cartilage and tooth development.	TGFB1 TGFB2	6.83e-06	3	53	2	8125201
Pubmed	Experimental manipulation of transforming growth factor-beta isoforms significantly affects adhesion formation in a murine surgical model.	TGFB1 TGFB2	6.83e-06	3	53	2	16192636
Pubmed	Differential expression of TGF beta isoforms in murine palatogenesis.	TGFB1 TGFB2	6.83e-06	3	53	2	2401212
Pubmed	Isoform-specific effects of transforming growth factor β on endothelial-to-mesenchymal transition.	TGFB1 TGFB2	6.83e-06	3	53	2	29856065
Pubmed	Transforming growth factor-beta gene polymorphisms in sarcoidosis patients with and without fibrosis.	TGFB1 TGFB2	6.83e-06	3	53	2	16778279
Pubmed	TGF-β1 mediated activation of Rho kinase induces TGF-β2 and endothelin-1 expression in human hepatic stellate cells.	TGFB1 TGFB2	6.83e-06	3	53	2	21087804
Pubmed	Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin.	TGFB1 TGFB2	6.83e-06	3	53	2	27377816
Pubmed	Transforming growth factor beta (TGFbeta1, TGFbeta2 and TGFbeta3) null-mutant phenotypes in embryonic gonadal development.	TGFB1 TGFB2	6.83e-06	3	53	2	18790002
Pubmed	Elevated TGFβ signaling contributes to ocular anterior segment dysgenesis in Col4a1 mutant mice.	TGFB1 TGFB2	6.83e-06	3	53	2	35525525
Pubmed	Transforming growth factor-beta isoform and receptor expression in chondrosarcoma of bone.	TGFB1 TGFB2	6.83e-06	3	53	2	12021923
Pubmed	Differential expression of TGFβ isoforms in breast cancer highlights different roles during breast cancer progression.	TGFB1 TGFB2	6.83e-06	3	53	2	29320969
Pubmed	Relationship between Axial Length and Levels of TGF-β in the Aqueous Humor and Plasma of Myopic Patients.	TGFB1 TGFB2	6.83e-06	3	53	2	33728344
Pubmed	Aberrant TGFβ Signaling Contributes to Altered Trophoblast Differentiation in Preeclampsia.	TGFB1 TGFB2	6.83e-06	3	53	2	26653761
Pubmed	In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2.	TGFB1 TGFB2	6.83e-06	3	53	2	1723948
Pubmed	Localization and binding of transforming growth factor-beta isoforms in mouse preimplantation embryos and in delayed and activated blastocysts.	TGFB1 TGFB2	6.83e-06	3	53	2	1577201
Pubmed	Transforming growth factor-beta. A family of growth regulatory peptides.	TGFB1 TGFB2	6.83e-06	3	53	2	2375595
Pubmed	Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo.	TGFB1 TGFB2	6.83e-06	3	53	2	1707784
Pubmed	Transforming growth factor-beta isoforms differently stimulate proalpha2 (I) collagen gene expression during wound healing process in transgenic mice.	TGFB1 TGFB2	6.83e-06	3	53	2	11857453
Pubmed	Long noncoding RNA SGO1-AS1 inactivates TGFβ signaling by facilitating TGFB1/2 mRNA decay and inhibits gastric carcinoma metastasis.	TGFB1 TGFB2	6.83e-06	3	53	2	34706749
Pubmed	Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1.	TGFB1 TGFB2	6.83e-06	3	53	2	8617200
Pubmed	FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma.	ARHGEF39 FARP1	6.83e-06	3	53	2	34731623
Pubmed	Developing human minor salivary glands: morphological parallel relation between the expression of TGF-beta isoforms and cytoskeletal markers of glandular maturation.	TGFB1 TGFB2	6.83e-06	3	53	2	18080134
Pubmed	Protective effect of estrogen receptors (ERα/β) against the intervertebral disc degeneration involves activating CCN5 via the promoter.	CCN5 ESR1	6.83e-06	3	53	2	33660790
Pubmed	Conversion of Th2 memory cells into Foxp3+ regulatory T cells suppressing Th2-mediated allergic asthma.	TGFB1 TGFB2	6.83e-06	3	53	2	20421479
Pubmed	Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease.	TGFB1 TGFB2	6.83e-06	3	53	2	2119582
Pubmed	Estrogen receptor alpha attenuates transforming growth factor-beta signaling in breast cancer cells independent from agonistic and antagonistic ligands.	TGFB1 ESR1	6.83e-06	3	53	2	19370415
Pubmed	Circulating levels of transforming growth factor beta-1, 2 and 3 in HIV associated preeclamptic pregnancies.	TGFB1 TGFB2	6.83e-06	3	53	2	36006052
Pubmed	Regulation of proliferation, motility, and contractivity of cultured human endometrial stromal cells by transforming growth factor-beta isoforms.	TGFB1 TGFB2	6.83e-06	3	53	2	16210002
Pubmed	TGF-beta isoforms in renal fibrogenesis.	TGFB1 TGFB2	6.83e-06	3	53	2	12911534
Cytoband	1p36.21	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	1.13e-08	63	53	5	1p36.21
Cytoband	6q25.1	ESR1 IYD	8.95e-04	38	53	2	6q25.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	1.13e-03	681	53	5	chr1p36
GeneFamily	PRAME family	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	1.53e-07	24	37	4	686
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS17 ADAMTS14	6.82e-04	19	37	2	50
Coexpression	KOHOUTEK_CCNT2_TARGETS	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	6.35e-07	81	53	5	MM938
Coexpression	KINNEY_DNMT1_METHYLATION_TARGETS	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	6.60e-07	34	53	4	MM955
Coexpression	DESCARTES_ORGANOGENESIS_SCHWANN_CELL_PRECURSOR	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	1.64e-06	98	53	5	MM3656
Coexpression	BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS	PRAMEF7 PRAMEF33 PRAMEF10 TCIRG1 PRAMEF17 PRAMEF8	1.69e-06	180	53	6	MM612
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	5.43e-06	57	53	4	MM1262
Coexpression	SANSOM_APC_TARGETS	PRAMEF7 PRAMEF33 PRAMEF10 MBOAT1 PRAMEF17 PRAMEF8	9.97e-06	245	53	6	MM735
Coexpression	INGRAM_SHH_TARGETS_UP	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	1.60e-05	156	53	5	MM550
Coexpression	KANG_IMMORTALIZED_BY_TERT_UP	TGFB1 TGFB2 C3 GPR162	3.06e-05	88	53	4	M5360
Coexpression	MORI_SMALL_PRE_BII_LYMPHOCYTE_UP	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	4.67e-05	98	53	4	MM592
Coexpression	HUANG_GATA2_TARGETS_DN	PRAMEF7 PRAMEF10 PRAMEF17 PRAMEF8	4.67e-05	98	53	4	MM942
Coexpression	GSE40277_EOS_AND_LEF1_TRANSDUCED_VS_GATA1_AND_SATB1_TRANSDUCED_CD4_TCELL_DN	MSRA DDX31 EPHX4 ALS2CL XKRX	5.12e-05	199	53	5	M9170
Coexpression	GSE12392_CD8A_POS_VS_NEG_SPLEEN_DC_UP	NPEPPS TCIRG1 C3 GPR162 IDNK	5.24e-05	200	53	5	M7135
Coexpression	GSE13522_CTRL_VS_T_CRUZI_Y_STRAIN_INF_SKIN_IFNAR_KO_UP	MSRA LIPA MBOAT1 ALS2CL XKRX	5.24e-05	200	53	5	M2929
Coexpression	BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	PRAMEF7 PRAMEF10 NPEPPS ESR1 IYD TCIRG1 PRAMEF17 USP39 PRAMEF8	5.65e-05	871	53	9	MM1005
Coexpression	MIKKELSEN_NPC_ICP_WITH_H3K4ME3	PRAMEF7 SUMF2 LIPA PRAMEF10 PRAMEF17 PRAMEF8 IDNK	6.13e-05	497	53	7	MM863
Coexpression	YAMAZAKI_TCEB3_TARGETS_DN	PRAMEF7 PRAMEF33 PRAMEF10 PRAMEF17 PRAMEF8	1.06e-04	232	53	5	MM1019
Coexpression	MIKKELSEN_ES_ICP_WITH_H3K4ME3	PRAMEF7 SUMF2 PRAMEF33 LIPA PRAMEF10 PRAMEF17 PRAMEF8 IDNK	2.03e-04	807	53	8	MM855
Coexpression	GSE10147_IL3_AND_HIVP17_VS_IL3_AND_CPG_STIM_PDC_UP	SYNDIG1L A3GALT2 ALS2CL GPR162	2.68e-04	154	53	4	M351
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ESR1 ESPNL A3GALT2 ADAMTS14	4.13e-05	162	53	4	68c40d12689cc1b6c797e6e48173f0110f8144e4
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ESR1 ESPNL A3GALT2 ADAMTS14	4.13e-05	162	53	4	735fa3f77b31a4189e431d05c326403c18cbbffb
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Spindle_Cell-1\|TCGA-Uvea / Sample_Type by Project: Shred V9	SEMA6C MED16 FARP1 CTNNBL1	4.76e-05	168	53	4	b427746929bb40e3d1b5f1c40d302b792d6b32a5
ToppCell	Immune_cells-Dendritic_cells\|World / Lineage and Cell class	GPR162 XKRX KYNU SLC22A12	4.99e-05	170	53	4	094dc211d80c89ecb1010855f1fe6eeb71bf0e20
ToppCell	facs-Heart-RV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFB2 ESR1 A3GALT2 C3	4.99e-05	170	53	4	d7c9a604311974ff87ece43a0f8725a234d262f7
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	WDR87 A3GALT2 ADAMTS14	5.04e-05	60	53	3	aa75fef294803ec6396c7d2c1f51d52bc4a5b43f
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	WDR87 A3GALT2 ADAMTS14	5.04e-05	60	53	3	069fbabfd0e48e5809ff01a026439fd0bd017779
ToppCell	droplet-Spleen-nan-18m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AGMO GPR162 SLC22A12 PNMA8B	5.10e-05	171	53	4	4e856441063e9825b6f87a1d3dd19c77dae4662c
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CCN5 MBOAT1 FARP1 ADAMTS17	5.46e-05	174	53	4	e5f12831187140e84b9a49e93b2376b9fefb1aec
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFB2 ESR1 A3GALT2 C3	5.71e-05	176	53	4	c0a084f7a8645262d61971f094689e02bf15b113
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFB2 ESR1 A3GALT2 C3	5.71e-05	176	53	4	cccf9201f6e2da7524b911a5961d3b227edab222
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR162 XKRX KYNU SLC22A12	6.09e-05	179	53	4	1757b9f3f4c634277a67c4f5a39d27d6b4937073
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR162 XKRX KYNU SLC22A12	6.23e-05	180	53	4	64f01494a4052186773720e10b4e7c724ff94547
ToppCell	facs-Marrow-B-cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR162 XKRX KYNU SLC22A12	6.36e-05	181	53	4	e2481291c236105774c53883e6f20da11941df9b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MSRA FARP1 AGMO SLC22A12	6.36e-05	181	53	4	9542c19edc9bd2cba68c01c2a8407705398e3011
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MSRA FARP1 AGMO SLC22A12	6.36e-05	181	53	4	8f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCell	facs-Marrow-B-cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR162 XKRX KYNU SLC22A12	6.36e-05	181	53	4	782716b8b1d447d2bbe09a693fa5ed7ebeac0efb
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MSRA AGMO IYD SLC22A12	6.50e-05	182	53	4	e1e58176f533092b6b974ca1ce8b02192a6e193d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MSRA FARP1 AGMO SLC22A12	6.50e-05	182	53	4	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MSRA AGMO IYD SLC22A12	6.50e-05	182	53	4	57bb5a2da976464ba7c4460106bd9f692008ebd9
ToppCell	COVID-19-lung-AT1\|lung / Disease (COVID-19 only), tissue and cell type	TGFB2 FARP1 ALS2CL DNAH14	6.64e-05	183	53	4	942530449e9c6583705eeb8f6f12621daea57252
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR162 XKRX KYNU SLC22A12	6.92e-05	185	53	4	65dcb0a7ee64990a34a87c167b44497107f035ee
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSRA LIPA IYD SLC22A12	6.92e-05	185	53	4	3e3217c99719fd1d2fa94e16be7712a7e5077152
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MSRA AGMO IYD SLC22A12	7.07e-05	186	53	4	8287146f0ba415ea04475588117d4668ae00f75c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MSRA AGMO IYD SLC22A12	7.22e-05	187	53	4	71eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TGFB1 LIPA TCIRG1 C3	7.83e-05	191	53	4	b5715eeb72a97b7bc87b83f6c289e225f58da842
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2-Excitatory_Neuron.Slc17a7.Tac2.Wif1_(Medial_habenular,_lateral_portion)\|Thalamus / BrainAtlas - Mouse McCarroll V32	CCN5 ARHGEF39 A3GALT2	1.19e-04	80	53	3	da18df34b4f630fe4fe3110e3c3c3602aef92aab
ToppCell	Striatum-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Striatum / BrainAtlas - Mouse McCarroll V32	WDR87 ESPNL ADAMTS17	1.37e-04	84	53	3	9417fffe0ba79f5851920258dcd0f6c09218be13
Disease	BRCAX breast cancer	DOCK1 ESR1 CTNNBL1	3.97e-06	20	46	3	EFO_0009443
Disease	v-set and transmembrane domain-containing protein 4 measurement	MED16 C3	3.55e-05	6	46	2	EFO_0803247
Disease	regulator of G-protein signaling 8 measurement	MED16 C3	4.97e-05	7	46	2	EFO_0801997
Disease	calcium/calmodulin-dependent protein kinase type 1D measurement	MED16 C3	6.62e-05	8	46	2	EFO_0008063
Disease	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 measurement	MED16 C3	6.62e-05	8	46	2	EFO_0801373
Disease	cellular retinoic acid-binding protein 1 measurement	MED16 C3	8.50e-05	9	46	2	EFO_0801463
Disease	Aortic Valve Insufficiency	TGFB1 TGFB2	1.30e-04	11	46	2	C0003504
Disease	oncostatin-M measurement	MED16 C3	1.55e-04	12	46	2	EFO_0010792
Disease	tyrosine-protein kinase ZAP-70 measurement	MED16 C3	1.55e-04	12	46	2	EFO_0020833
Disease	colon carcinoma (is_marker_for)	TGFB1 TGFB2	1.83e-04	13	46	2	DOID:1520 (is_marker_for)
Disease	heel bone mineral density, urate measurement	STXBP5 FARP1 AGMO DNAH14	1.87e-04	182	46	4	EFO_0004531, EFO_0009270
Disease	sickle cell anemia (is_marker_for)	TGFB1 C3	2.14e-04	14	46	2	DOID:10923 (is_marker_for)
Disease	body fat distribution	TGFB2 ESR1 ADAMTS17 ADAMTS14	2.78e-04	202	46	4	EFO_0004341
Disease	Pulmonary Emphysema	TGFB1 TGFB2	3.19e-04	17	46	2	C0034067
Disease	diabetic neuropathy (biomarker_via_orthology)	TGFB1 TGFB2	3.19e-04	17	46	2	DOID:9743 (biomarker_via_orthology)
Disease	physical activity	MBOAT1 FARP1 ESR1	3.55e-04	88	46	3	EFO_0003940
Disease	Acute Kidney Insufficiency	TGFB1 C3 SLC22A12	5.31e-04	101	46	3	C1565662
Disease	Acute kidney injury	TGFB1 C3 SLC22A12	5.31e-04	101	46	3	C2609414
Disease	Kidney Failure, Acute	TGFB1 C3 SLC22A12	5.31e-04	101	46	3	C0022660
Disease	osteoporosis (biomarker_via_orthology)	TGFB1 ESR1	5.38e-04	22	46	2	DOID:11476 (biomarker_via_orthology)
Disease	Ureteral obstruction	TGFB1 TGFB2	6.42e-04	24	46	2	C0041956
Disease	aggressive behavior	MBOAT1 IYD	6.97e-04	25	46	2	EFO_0003015
Disease	Drug habituation	DOCK1 MSRA FARP1	7.75e-04	115	46	3	C0013170
Disease	Substance-Related Disorders	DOCK1 MSRA FARP1	7.75e-04	115	46	3	C0236969
Disease	Drug abuse	DOCK1 MSRA FARP1	7.75e-04	115	46	3	C0013146
Disease	Drug Use Disorders	DOCK1 MSRA FARP1	7.75e-04	115	46	3	C0013222
Disease	Drug Dependence	DOCK1 MSRA FARP1	7.75e-04	115	46	3	C1510472
Disease	Substance Dependence	DOCK1 MSRA FARP1	7.75e-04	115	46	3	C0038580
Disease	Substance Use Disorders	DOCK1 MSRA FARP1	7.75e-04	115	46	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	DOCK1 MSRA FARP1	7.75e-04	115	46	3	C0029231
Disease	Prescription Drug Abuse	DOCK1 MSRA FARP1	7.75e-04	115	46	3	C4316881
Disease	Substance abuse problem	DOCK1 MSRA FARP1	7.94e-04	116	46	3	C0740858
Disease	macular degeneration (is_implicated_in)	ESR1 C3	8.14e-04	27	46	2	DOID:4448 (is_implicated_in)
Disease	pancreatic ductal adenocarcinoma (is_marker_for)	TGFB1 TGFB2	8.14e-04	27	46	2	DOID:3498 (is_marker_for)
Disease	factor VIII measurement, von Willebrand factor measurement	DDX31 STXBP5	8.14e-04	27	46	2	EFO_0004629, EFO_0004630
Disease	von Willebrand factor measurement, coronary artery disease	TGFB1 DDX31 STXBP5	8.35e-04	118	46	3	EFO_0001645, EFO_0004629
Disease	osteoarthritis (is_implicated_in)	ESR1 ADAMTS14	8.76e-04	28	46	2	DOID:8398 (is_implicated_in)
Disease	Ischemic stroke, von Willebrand factor measurement	DDX31 STXBP5	1.01e-03	30	46	2	EFO_0004629, HP_0002140

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLRLPLGSLMKTPHL	PRAMEF33	61	A0A0G2JMD5
SLHPLGKLLRTLMLT	ALS2CL	681	Q60I27
ILGLRTIFPLFMKSP	CTNNBL1	376	Q8WYA6
LMLYRFGHLKPLVPS	AGMO	401	Q6ZNB7
LLLLTHLPLALGSPM	C3	11	P01024
MAPLRALLSYLLPLH	ADAMTS14	1	Q8WXS8
GPTKLPLHLMVLLFH	ADAMTS17	756	Q8TE56
LMAKPRPPLHLLRSG	ARHGEF39	256	Q8N4T4
LLLLHSLFPVPRMGN	MSRA	11	Q9UJ68
AMLPTAGHLLPLLLV	LRRC3C	21	A6NJW4
HTPILDRLLLMGTPI	ESPNL	251	Q6ZVH7
FLRLPLGSLMKTPHL	PRAMEF17	61	Q5VTA0
KLLPGRHMLFPPLER	GPR162	386	Q16538
RGKPLMLLLHGFPEF	EPHX4	91	Q8IUS5
MEHPGKLLFAPNLLL	ESR1	396	P03372
MRCLPGLHPIFKFLI	ALOX12	376	P18054
RLHSLGLAAMPEKRP	NPEPPSL1	36	A6NEC2
LPSASMRLKFLRLHG	DDX31	546	Q9H8H2
KLSVLRLSPSMGHPL	MED16	451	Q9Y2X0
GPSVVRYHLPKMLLL	HEATR5B	566	Q9P2D3
ISGRLLKREGHFMPP	IDNK	131	Q5T6J7
GFALEPLLPKKMHSR	DOCK1	1666	Q14185
LPLNTFLLRPLHRLM	FARP1	676	Q9Y4F1
LSGLRRKPKQLMTPH	CCDC191	641	Q8NCU4
MRGTPKTHLLAFSLL	CCN5	1	O76076
GLPKFRHLEALIPMG	A3GALT2	31	U3KPV4
SPRLLKHFSMLVLPH	DNAH14	1986	Q0VDD8
HIISLLIILFLPMKP	MBOAT1	461	Q6ZNC8
FTRLPLGSLMKSPHL	PRAMEF8	61	Q5VWM4
PAKMGALLLLSHLGR	SLC22A12	391	Q96S37
MLGFITRPPHRFLSL	NIT1	1	Q86X76
RLHSLGLAAMPEKRP	NPEPPS	36	P55786
LGRPAHEKLLMLLPV	IYD	251	Q6PHW0
LPPRDHLGLTLFSML	SYNDIG1L	156	A6NDD5
MARHGLPLLPLLSLL	SUMF2	1	Q8NBJ7
GSMRIFTKKLPHPDL	USP39	351	Q53GS9
MSSRPLHPVLLTIGL	TDRD12	516	Q587J7
PTLLPLGTFRLRHMK	PNMA8B	41	Q9ULN7
GHIMTFSLPSLRPLL	STXBP5	966	Q5T5C0
GKTPHLLLMLLPSYR	TGFB2	276	P61812
FTRLPLGSLMKSPHL	PRAMEF7	61	Q5VXH5
LLHLPELFSPGMLVR	PDCD11	136	Q14690
PKMHLLFPLTLVRSF	TMEM59	136	Q9BXS4
MQILGSTLKLFRHPP	nan	116	Q8N2B8
MAKLSPIPHTLLGIR	ZNF826P	16	Q6ZT77
PIPHTLLGIRKFMLE	ZNF826P	21	Q6ZT77
HGMNRPFLLLMATPL	TGFB1	251	P01137
MPSPRILKTHLPFHL	SULT1C4	106	O75897
FLRLPLGSLMKTPHL	PRAMEF10	61	O60809
MPRAPHFMPLLLLLL	SEMA6C	1	Q9H3T2
RPLMKLLEISGHGIP	PLPP6	131	Q8IY26
KPLSLFMHLILLGPV	XKRX	96	Q6PP77
LKLLPPALLTRLSFM	WDR87	636	Q6ZQQ6
LAMVPILLLGTPLHL	TCIRG1	641	Q13488
LHLLMLSFFKPTPKR	KYNU	141	Q16719
SPMAKLGRLPDHLIK	LIPA	211	P38571