Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranslation activator activity

DAZ4 DAZ1 DAZ3 DAZ2

3.61e-0815474GO:0008494
GeneOntologyMolecularFunctiontranscription coregulator activity

ATF7IP MED9 BRD4 WWTR1 ELK1 SIN3A SRCAP KMT2E

4.48e-05562478GO:0003712
GeneOntologyMolecularFunctionstructural constituent of tooth enamel

AMELX AMELY

8.09e-056472GO:0030345
GeneOntologyMolecularFunctiontranslation regulator activity, nucleic acid binding

DAZ4 DAZ1 DAZ3 DAZ2

1.39e-04112474GO:0090079
GeneOntologyMolecularFunctionhydroxyapatite binding

AMELX AMELY

1.50e-048472GO:0046848
GeneOntologyMolecularFunctionsodium ion binding

AMELX AMELY

4.85e-0414472GO:0031402
GeneOntologyMolecularFunctiontranscription coactivator activity

BRD4 WWTR1 ELK1 SRCAP KMT2E

7.09e-04303475GO:0003713
GeneOntologyMolecularFunctionextracellular matrix structural constituent conferring compression resistance

AMELX AMELY

1.33e-0323472GO:0030021
GeneOntologyMolecularFunctionchromatin binding

TNRC18 SFPQ ATXN7 BRD4 ELK1 SIN3A MNT

1.60e-03739477GO:0003682
GeneOntologyMolecularFunctionalkali metal ion binding

AMELX AMELY

1.70e-0326472GO:0031420
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

IQSEC3 ARHGEF11 ARHGEF16 SOS2

2.11e-03231474GO:0005085
GeneOntologyBiologicalProcessfemale meiosis II

DAZ4 DAZ1 DAZ3 DAZ2

3.54e-106474GO:0007147
GeneOntologyBiologicalProcessmeiosis II

DAZ4 DAZ1 DAZ3 DAZ2

3.54e-106474GO:0007135
GeneOntologyBiologicalProcessmeiosis II cell cycle process

DAZ4 DAZ1 DAZ3 DAZ2

3.54e-106474GO:0061983
GeneOntologyBiologicalProcesspositive regulation of meiotic nuclear division

DAZ4 DAZ1 DAZ3 DAZ2

3.41e-0726474GO:0045836
GeneOntologyBiologicalProcesspositive regulation of cell cycle process

SFPQ DAZ4 BRD4 DAZ1 SIN3A DAZ3 DAZ2 KMT2E

4.18e-07307478GO:0090068
GeneOntologyBiologicalProcesspositive regulation of translational initiation

DAZ4 DAZ1 DAZ3 DAZ2

5.39e-0729474GO:0045948
GeneOntologyBiologicalProcess3'-UTR-mediated mRNA stabilization

DAZ4 DAZ1 DAZ3 DAZ2

7.12e-0731474GO:0070935
GeneOntologyBiologicalProcesspositive regulation of meiotic cell cycle

DAZ4 DAZ1 DAZ3 DAZ2

1.48e-0637474GO:0051446
GeneOntologyBiologicalProcessregulation of meiotic nuclear division

DAZ4 DAZ1 DAZ3 DAZ2

3.29e-0645474GO:0040020
GeneOntologyBiologicalProcesspositive regulation of cell cycle

SFPQ DAZ4 BRD4 DAZ1 SIN3A DAZ3 DAZ2 KMT2E

3.44e-06407478GO:0045787
GeneOntologyBiologicalProcessoocyte maturation

DAZ4 DAZ1 DAZ3 DAZ2

3.93e-0647474GO:0001556
GeneOntologyBiologicalProcessfemale meiotic nuclear division

DAZ4 DAZ1 DAZ3 DAZ2

5.91e-0652474GO:0007143
GeneOntologyBiologicalProcessnegative regulation of mRNA metabolic process

DAZ4 ACIN1 DAZ1 DAZ3 DAZ2

6.28e-06115475GO:1903312
GeneOntologyBiologicalProcesspositive regulation of nuclear division

DAZ4 DAZ1 DAZ3 DAZ2

2.55e-0575474GO:0051785
GeneOntologyBiologicalProcessmRNA stabilization

DAZ4 DAZ1 DAZ3 DAZ2

2.83e-0577474GO:0048255
GeneOntologyBiologicalProcessregulation of meiotic cell cycle

DAZ4 DAZ1 DAZ3 DAZ2

3.63e-0582474GO:0051445
GeneOntologyBiologicalProcessnegative regulation of mRNA catabolic process

DAZ4 DAZ1 DAZ3 DAZ2

4.59e-0587474GO:1902373
GeneOntologyBiologicalProcessRNA stabilization

DAZ4 DAZ1 DAZ3 DAZ2

4.80e-0588474GO:0043489
GeneOntologyBiologicalProcessregulation of translational initiation

DAZ4 DAZ1 DAZ3 DAZ2

5.47e-0591474GO:0006446
GeneOntologyBiologicalProcessoocyte development

DAZ4 DAZ1 DAZ3 DAZ2

7.60e-0599474GO:0048599
GeneOntologyBiologicalProcessnegative regulation of RNA catabolic process

DAZ4 DAZ1 DAZ3 DAZ2

8.22e-05101474GO:1902369
GeneOntologyBiologicalProcessoocyte differentiation

DAZ4 DAZ1 DAZ3 DAZ2

8.87e-05103474GO:0009994
GeneOntologyBiologicalProcessregulation of cell cycle

SFPQ DAZ4 BRD4 PPP1R9B DAZ1 E2F5 SIN3A DAZ3 DAZ2 KMT2E MNT

9.32e-0512564711GO:0051726
GeneOntologyBiologicalProcessregulation of cell cycle process

SFPQ DAZ4 BRD4 PPP1R9B DAZ1 SIN3A DAZ3 DAZ2 KMT2E

1.05e-04845479GO:0010564
GeneOntologyBiologicalProcesspositive regulation of reproductive process

DAZ4 DAZ1 DAZ3 DAZ2

1.50e-04118474GO:2000243
GeneOntologyBiologicalProcessmeiotic nuclear division

DAZ4 DAZ1 DAZ3 DAZ2 BAG6

2.11e-04240475GO:0140013
GeneOntologyBiologicalProcesstranslational initiation

DAZ4 DAZ1 DAZ3 DAZ2

2.31e-04132474GO:0006413
GeneOntologyBiologicalProcesscell cycle process

SFPQ DAZ4 BRD4 PPP1R9B DAZ1 E2F5 SIN3A DAZ3 DAZ2 KMT2E BAG6

3.12e-0414414711GO:0022402
GeneOntologyBiologicalProcessmeiotic cell cycle process

DAZ4 DAZ1 DAZ3 DAZ2 BAG6

3.50e-04268475GO:1903046
GeneOntologyBiologicalProcessprotein-DNA complex organization

ZNF462 SFPQ ATF7IP MED9 BRD4 SIN3A SRCAP KMT2E BAG6

3.66e-04999479GO:0071824
GeneOntologyBiologicalProcesspositive regulation of translation

DAZ4 DAZ1 DAZ3 DAZ2

3.85e-04151474GO:0045727
GeneOntologyBiologicalProcessoogenesis

DAZ4 DAZ1 DAZ3 DAZ2

4.36e-04156474GO:0048477
GeneOntologyBiologicalProcessregulation of mRNA metabolic process

DAZ4 CELF3 ACIN1 DAZ1 DAZ3 DAZ2

4.83e-04443476GO:1903311
GeneOntologyBiologicalProcessnegative regulation of circadian rhythm

SFPQ SIN3A

5.98e-0416472GO:0042754
GeneOntologyBiologicalProcessregulation of nuclear division

DAZ4 DAZ1 DAZ3 DAZ2

6.30e-04172474GO:0051783
GeneOntologyBiologicalProcesschromatin organization

ZNF462 SFPQ ATF7IP BRD4 SIN3A SRCAP KMT2E BAG6

8.57e-04896478GO:0006325
GeneOntologyBiologicalProcessmRNA metabolic process

SFPQ DAZ4 CELF3 ACIN1 DAZ1 DAZ3 DAZ2 CPSF7

9.96e-04917478GO:0016071
GeneOntologyBiologicalProcessnuclear division

DAZ4 PPP1R9B DAZ1 DAZ3 DAZ2 BAG6

1.03e-03512476GO:0000280
GeneOntologyBiologicalProcessmeiotic cell cycle

DAZ4 DAZ1 DAZ3 DAZ2 BAG6

1.17e-03350475GO:0051321
GeneOntologyBiologicalProcessenamel mineralization

AMELX AMELY

1.47e-0325472GO:0070166
GeneOntologyBiologicalProcessfemale gamete generation

DAZ4 DAZ1 DAZ3 DAZ2

1.65e-03223474GO:0007292
GeneOntologyBiologicalProcessorganelle fission

DAZ4 PPP1R9B DAZ1 DAZ3 DAZ2 BAG6

1.80e-03571476GO:0048285
GeneOntologyBiologicalProcesspositive regulation of organelle organization

SFPQ DAZ4 ATF7IP DAZ1 DAZ3 DAZ2

1.84e-03574476GO:0010638
GeneOntologyCellularComponentnuclear body

SFPQ ATF7IP CELF3 ACIN1 NHS PTPN23 WWTR1 SRCAP KMT2E

1.85e-04903489GO:0016604
GeneOntologyCellularComponenttranscription regulator complex

SFPQ ATXN7 ATF7IP MED9 WWTR1 E2F5 SIN3A

3.95e-04596487GO:0005667
GeneOntologyCellularComponentnuclear protein-containing complex

SFPQ ATXN7 MED9 BRD4 ACIN1 E2F5 SIN3A SRCAP KMT2E CPSF7

9.73e-0413774810GO:0140513
GeneOntologyCellularComponenthistone deacetylase complex

SIN3A SRCAP KMT2E

9.83e-0485483GO:0000118
HumanPhenoY-linked inheritance

DAZ1 DAZ3 DAZ2

4.07e-0518203HP:0001450
HumanPhenoCryptorchidism

ZNF462 DAZ4 BRD4 FBXO11 DAZ1 SIN3A DAZ3 DAZ2 SRCAP KMT2E SOS2

4.50e-057802011HP:0000028
HumanPhenoOligozoospermia

DAZ4 DAZ1 DAZ3 DAZ2

6.85e-0559204HP:0000798
MousePhenoshort Tomes' process

AMELX AMELY

9.24e-062432MP:0030513
MousePhenoabsent ovarian follicles

DAZ4 DAZ1 DAZ3 DAZ2

1.75e-0551434MP:0002777
MousePhenoabnormal Tomes' process morphology

AMELX AMELY

2.77e-053432MP:0030512
MousePhenolarge mandible

AMELX AMELY

5.52e-054432MP:0030050
MousePhenoenamel pits

AMELX AMELY

9.19e-055432MP:0030460
MousePhenoshort upper incisors

AMELX AMELY

1.38e-046432MP:0030090
MousePhenosmall upper incisors

AMELX AMELY

1.92e-047432MP:0030081
MousePhenoshort lower incisors

AMELX AMELY

1.92e-047432MP:0030089
MousePhenoabnormal enamel rod pattern

AMELX AMELY

2.56e-048432MP:0002649
MousePhenoabnormal tooth wear

AMELX AMELY

4.09e-0410432MP:0030458
MousePhenodecreased post-tetanic potentiation

ATXN7 SYN2

4.99e-0411432MP:0002922
MousePhenosmall lower incisors

AMELX AMELY

4.99e-0411432MP:0030080
MousePhenobrittle teeth

AMELX AMELY

5.98e-0412432MP:0000126
MousePhenoreduced enamel thickness

AMELX AMELY

5.98e-0412432MP:0002577
MousePhenoincreased lung tissue damping

AMELX AMELY

7.06e-0413432MP:0011047
MousePhenoabnormal enamel mineralization

AMELX AMELY

7.06e-0413432MP:0030450
MousePhenoarrest of spermatogenesis

DAZ4 DAZ1 DAZ3 DAZ2 HSF5

7.94e-04239435MP:0001155
MousePhenoshort incisors

AMELX AMELY

8.22e-0414432MP:0004830
MousePhenoabnormal seminiferous tubule morphology

DAZ4 BRD4 DAZ1 E2F5 DAZ3 DAZ2

9.69e-04377436MP:0002216
MousePhenoabnormal lung tissue damping

AMELX AMELY

1.08e-0316432MP:0011046
MousePhenoabnormal molar cusp morphology

AMELX AMELY

1.08e-0316432MP:0030457
MousePhenoabnormal incisor color

AMELX AMELY

1.08e-0316432MP:0010096
DomainRRM

SFPQ DAZ4 CELF3 ACIN1 DAZ1 DAZ3 DAZ2 CPSF7

6.22e-08217478SM00360
DomainRRM_dom

SFPQ DAZ4 CELF3 ACIN1 DAZ1 DAZ3 DAZ2 CPSF7

8.80e-08227478IPR000504
Domain-

SFPQ DAZ4 CELF3 ACIN1 DAZ1 DAZ3 DAZ2 CPSF7

1.53e-072444783.30.70.330
DomainNucleotide-bd_a/b_plait

SFPQ DAZ4 CELF3 ACIN1 DAZ1 DAZ3 DAZ2 CPSF7

2.35e-07258478IPR012677
DomainRRM_1

SFPQ DAZ4 CELF3 DAZ1 DAZ3 DAZ2 CPSF7

8.28e-07208477PF00076
DomainRRM

SFPQ DAZ4 CELF3 DAZ1 DAZ3 DAZ2 CPSF7

1.62e-06230477PS50102
DomainAmelogenin

AMELX AMELY

6.20e-062472IPR004116
DomainAmelogenin

AMELX AMELY

6.20e-062472SM00818
DomainAmelogenin

AMELX AMELY

6.20e-062472PF02948
DomainGDS_CDC24_CS

ARHGEF11 ARHGEF16 SOS2

1.28e-0439473IPR001331
DomainDH_1

ARHGEF11 ARHGEF16 SOS2

5.34e-0463473PS00741
DomainPH

IQSEC3 PHLPP1 ARHGEF11 ARHGEF16 SOS2

6.48e-04278475SM00233
DomainPH_DOMAIN

IQSEC3 PHLPP1 ARHGEF11 ARHGEF16 SOS2

6.59e-04279475PS50003
DomainPH_dom-like

IQSEC3 NBEAL2 PHLPP1 ARHGEF11 ARHGEF16 SOS2

6.61e-04426476IPR011993
DomainRhoGEF

ARHGEF11 ARHGEF16 SOS2

6.67e-0468473SM00325
DomainPH_domain

IQSEC3 PHLPP1 ARHGEF11 ARHGEF16 SOS2

6.70e-04280475IPR001849
DomainDH_2

ARHGEF11 ARHGEF16 SOS2

7.26e-0470473PS50010
DomainRhoGEF

ARHGEF11 ARHGEF16 SOS2

7.26e-0470473PF00621
DomainDH-domain

ARHGEF11 ARHGEF16 SOS2

7.57e-0471473IPR000219
Domain-

ARHGEF11 ARHGEF16 SOS2

7.57e-04714731.20.900.10
Domain-

FOXB2 ELK1 E2F5 HSF5

2.17e-032184741.10.10.10
Domain-

IQSEC3 PHLPP1 ARHGEF11 ARHGEF16 SOS2

2.92e-033914752.30.29.30
DomainWHTH_DNA-bd_dom

FOXB2 ELK1 E2F5 HSF5

3.17e-03242474IPR011991
DomainF-box

FBXO28 FBXO11

1.24e-0267472PF00646
PathwayWP_OVARIAN_INFERTILITY

DAZ4 DAZ1 DAZ3 DAZ2

2.46e-0635394MM15948
PathwayWP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY

ZNF219 NACC1 DAZ4 DAZ1 SIN3A DAZ3 DAZ2

1.61e-05301397MM15983
PathwayWP_MRNA_PROCESSING

SFPQ DAZ4 CELF3 ACIN1 DAZ1 DAZ3 DAZ2 CPSF7

2.65e-05451398MM15946
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

ARHGEF11 ARHGEF16 SOS2

3.94e-0452393MM14743
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

ARHGEF11 ARHGEF16 SOS2

5.72e-0459393M11215
PathwayWP_MALE_INFERTILITY

DAZ4 DAZ1 DAZ3 DAZ2

6.68e-04145394M39856
PathwayKEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY

ELK1 SOS2

7.65e-0415392M47593
PathwayWP_MAPK_PATHWAY_IN_CONGENITAL_THYROID_CANCER

ELK1 SOS2

8.73e-0416392M39882
PathwayREACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE

ARHGEF11 ARHGEF16 SOS2

9.43e-0470393MM14824
PathwayREACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE

ARHGEF11 ARHGEF16 SOS2

1.20e-0376393M19832
PathwayREACTOME_RHO_GTPASE_CYCLE

NHS ARHGEF11 ARHGEF16 GARRE1 CPSF7 SOS2

1.20e-03439396MM15595
PathwayREACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS

ARHGEF11 ARHGEF16 SOS2

1.24e-0377393MM15044
PathwayREACTOME_RAC1_GTPASE_CYCLE

NHS ARHGEF11 GARRE1 SOS2

1.34e-03175394MM15599
PathwayREACTOME_RHO_GTPASE_CYCLE

NHS ARHGEF11 ARHGEF16 GARRE1 CPSF7 SOS2

1.36e-03450396M27078
PathwayREACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS

ARHGEF11 ARHGEF16 SOS2

1.39e-0380393M800
PathwayREACTOME_RAC1_GTPASE_CYCLE

NHS ARHGEF11 GARRE1 SOS2

1.62e-03184394M41809
PathwayREACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING

ARHGEF11 ARHGEF16 SOS2

1.65e-0385393MM14746
PathwayWP_EGFR1_SIGNALING_PATHWAY

REPS1 ELK1 SIN3A SOS2

1.75e-03188394MM15828
Pubmed

Analysis of the DAZ gene family in cryptorchidism and idiopathic male infertility.

DAZ4 DAZ1 DAZ3 DAZ2

3.48e-12449415066457
Pubmed

Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene.

DAZ4 DAZ1 DAZ3 DAZ2

3.48e-1244947670487
Pubmed

Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.

DAZ4 DAZ1 DAZ3 DAZ2

3.48e-12449426232607
Pubmed

Male infertility, genetic analysis of the DAZ genes on the human Y chromosome and genetic analysis of DNA repair.

DAZ4 DAZ1 DAZ3 DAZ2

3.48e-12449411694340
Pubmed

The human DAZ genes, a putative male infertility factor on the Y chromosome, are highly polymorphic in the DAZ repeat regions.

DAZ4 DAZ1 DAZ3 DAZ2

3.48e-1244949321470
Pubmed

Polymorphic expression of DAZ proteins in the human testis.

DAZ4 DAZ1 DAZ3 DAZ2

3.48e-12449419223287
Pubmed

Male infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome.

DAZ4 DAZ1 DAZ3 DAZ2

3.48e-12449411095434
Pubmed

[Microdeletion of chromosome Y in male infertility: role of the DAZ gene].

DAZ4 DAZ1 DAZ3 DAZ2

3.48e-12449411688365
Pubmed

Polymorphic DAZ gene family in polymorphic structure of AZFc locus: Artwork or functional for human spermatogenesis?

DAZ4 DAZ1 DAZ3 DAZ2

3.48e-12449412752250
Pubmed

A novel approach for the analysis of DAZ gene copy number in severely idiopathic infertile men.

DAZ4 DAZ1 DAZ3 DAZ2

3.48e-12449411883873
Pubmed

Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.

DAZ4 DAZ1 DAZ3 DAZ2

3.48e-12449410936047
Pubmed

[Study on DAZ gene copy deletion in severe oligozoospermia sperm donor for ICSI].

DAZ4 DAZ1 DAZ3 DAZ2

3.48e-12449416963411
Pubmed

Partial DAZ deletions in a family with five infertile brothers.

DAZ4 DAZ1 DAZ3 DAZ2

3.48e-12449412801575
Pubmed

Mouse Dazl and its novel splice variant functions in translational repression of target mRNAs in embryonic stem cells.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549423298641
Pubmed

Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549423579190
Pubmed

DAZL is essential for stress granule formation implicated in germ cell survival upon heat stress.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549422223682
Pubmed

Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549422021443
Pubmed

The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-1154949288969
Pubmed

The dazzle in germ cell differentiation.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549420008336
Pubmed

Co-culture of spermatogonial stem cells with sertoli cells in the presence of testosterone and FSH improved differentiation via up-regulation of post meiotic genes.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549423456578
Pubmed

Isolation of a mouse homolog of the human DAZ (Deleted in Azoospermia) gene.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-1154948679003
Pubmed

A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549410393944
Pubmed

The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-1154948968756
Pubmed

A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-1154948968755
Pubmed

DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549430380414
Pubmed

Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549426411291
Pubmed

In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549410903443
Pubmed

Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549423223451
Pubmed

Somatic cell-derived BMPs induce premature meiosis in male germ cells during the embryonic stage by upregulating Dazl expression.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549434985827
Pubmed

Identification of target messenger RNA substrates for the murine deleted in azoospermia-like RNA-binding protein.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549411804965
Pubmed

Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-1154949143498
Pubmed

Expression profiling of the developing testis in wild-type and Dazl knockout mice.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549414648873
Pubmed

Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549422699882
Pubmed

A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonads.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-1154948845845
Pubmed

The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-1154948896558
Pubmed

DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549411058556
Pubmed

AZFc partial deletions in Chilean men with severe spermatogenic failure.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549417416365
Pubmed

Dazl promotes germ cell differentiation from embryonic stem cells.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549419783541
Pubmed

Retinoic acid regulates germ cell differentiation in mouse embryonic stem cells through a Smad-dependent pathway.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549422293198
Pubmed

DAZL protein expression in mouse preimplantation embryo.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549417761180
Pubmed

Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549419468308
Pubmed

Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-1154949700189
Pubmed

Partial rescue of the Dazl knockout mouse by the human DAZL gene.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549412200456
Pubmed

Nature of the spermatogenic arrest in Dazl -/- mice.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549411514340
Pubmed

Decreased oocyte DAZL expression in mice results in increased litter size by modulating follicle-stimulating hormone-induced follicular growth.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549421270429
Pubmed

Loss of oocytes in Dazl knockout mice results in maintained ovarian steroidogenic function but altered gonadotropin secretion in adult animals.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-11549411089564
Pubmed

Mouse autosomal homolog of DAZ, a candidate male sterility gene in humans, is expressed in male germ cells before and after puberty.

DAZ4 DAZ1 DAZ3 DAZ2

1.74e-1154948661148
Pubmed

The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649432170089
Pubmed

Expression profiles of the DAZ gene family in human testis with and without spermatogenic failure.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649415066460
Pubmed

Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649416278232
Pubmed

Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649420157580
Pubmed

DAZL binds to the transcripts of several Tssk genes in germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649418452650
Pubmed

A gene trap mutation of a murine homolog of the Drosophila stem cell factor Pumilio results in smaller testes but does not affect litter size or fertility.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649417219433
Pubmed

Mono-butyl phthalate-induced mouse testis injury is associated with oxidative stress and down-regulated expression of Sox9 and Dazl.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649428496037
Pubmed

DAZL regulates Tet1 translation in murine embryonic stem cells.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649426077710
Pubmed

The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649416001084
Pubmed

Cracd Marks the First Wave of Meiosis during Spermatogenesis and Is Mis-Expressed in Azoospermia Mice.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649432962040
Pubmed

Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649417526644
Pubmed

Genetic mapping of a male germ cell-expressed gene Tpx-2 to mouse chromosome 17.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-1164941869307
Pubmed

A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649411390979
Pubmed

A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649424086306
Pubmed

BOULE, a Deleted in Azoospermia Homolog, Is Recruited to Stress Granules in the Mouse Male Germ Cells.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649427632217
Pubmed

The mouse male germ cell-specific gene Tpx-1: molecular structure, mode of expression in spermatogenesis, and sequence similarity to two non-mammalian genes.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-1164941638086
Pubmed

Spermatogenesis in testes of Dazl null mice after transplantation of wild-type germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649414611632
Pubmed

DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1 expression.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649419247806
Pubmed

DAZL is a master translational regulator of murine spermatogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649431355046
Pubmed

The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers.

DAZ4 DAZ1 DAZ3 DAZ2

5.20e-11649423417416
Pubmed

The RNA-binding specificity of the mouse Dazl protein.

DAZ4 DAZ1 DAZ3 DAZ2

1.21e-10749411410654
Pubmed

Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

1.21e-10749415081113
Pubmed

Sertoli-cell-specific knockout of connexin 43 leads to multiple alterations in testicular gene expression in prepubertal mice.

DAZ4 DAZ1 DAZ3 DAZ2

1.21e-10749422699423
Pubmed

Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL.

DAZ4 DAZ1 DAZ3 DAZ2

1.21e-10749411604102
Pubmed

Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.

DAZ4 DAZ1 DAZ3 DAZ2

1.21e-10749410857750
Pubmed

The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation.

DAZ4 DAZ1 DAZ3 DAZ2

1.21e-1074949588208
Pubmed

DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.

DAZ4 DAZ1 DAZ3 DAZ2

1.21e-10749426826184
Pubmed

Dazl can bind to dynein motor complex and may play a role in transport of specific mRNAs.

DAZ4 DAZ1 DAZ3 DAZ2

1.21e-10749416946704
Pubmed

Fanconi anemia complementation group C is required for proliferation of murine primordial germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

2.42e-10849410951504
Pubmed

Single-cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination.

DAZ4 DAZ1 DAZ3 DAZ2

2.42e-10849433749946
Pubmed

Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

DAZ4 DAZ1 DAZ3 DAZ2

2.42e-10849423204224
Pubmed

Requirement of the 3'-UTR-dependent suppression of DAZL in oocytes for pre-implantation mouse development.

DAZ4 DAZ1 DAZ3 DAZ2

2.42e-10849429883445
Pubmed

Mouse dead end1 acts with Nanos2 and Nanos3 to regulate testicular teratoma incidence.

DAZ4 DAZ1 DAZ3 DAZ2

2.42e-10849432339196
Pubmed

A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection.

DAZ4 DAZ1 DAZ3 DAZ2

2.42e-10849410823932
Pubmed

Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice.

DAZ4 DAZ1 DAZ3 DAZ2

2.42e-10849422621333
Pubmed

DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors.

DAZ4 DAZ1 DAZ3 DAZ2

2.42e-10849432686646
Pubmed

A preliminary report on the implication of RT-PCR detection of DAZ, RBMY1, USP9Y and Protamine-2 mRNA in testicular biopsy samples from azoospermic men.

DAZ4 DAZ1 DAZ3 DAZ2

2.42e-10849411869379
Pubmed

A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary.

DAZ4 DAZ1 DAZ3 DAZ2

4.36e-10949426378784
Pubmed

Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL/6 mice.

DAZ4 DAZ1 DAZ3 DAZ2

4.36e-10949416310179
Pubmed

Embryoid bodies from mouse stem cells express oxytocin receptor, Oct-4 and DAZL.

DAZ4 DAZ1 DAZ3 DAZ2

4.36e-10949419695304
Pubmed

The epigenetic modifications and the anterior to posterior characterization of meiotic entry during mouse oogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

4.36e-10949428235998
Pubmed

Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

4.36e-10949420159962
Pubmed

The periphilin 1-like BFAR isoform 3 is highly expressed in transcriptionally silent oocytes and involved in RNA metabolism.

SFPQ DAZ4 DAZ1 DAZ3 DAZ2

5.21e-102949534175335
Pubmed

Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype.

DAZ4 DAZ1 DAZ3 DAZ2

7.25e-101049410601091
Pubmed

Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

7.25e-101049431234534
Pubmed

Tesmin transcription is regulated differently during male and female meiosis.

DAZ4 DAZ1 DAZ3 DAZ2

7.25e-101049414648882
Pubmed

MAX controls meiotic entry in sexually undifferentiated germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

7.25e-101049438433229
Pubmed

Knockout mouse model and gametogenic failure.

DAZ4 DAZ1 DAZ3 DAZ2

7.25e-10104949922113
Pubmed

SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60.

DAZ4 DAZ1 DAZ3 DAZ2

7.25e-101049423810942
Pubmed

The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence.

DAZ4 DAZ1 DAZ3 DAZ2

7.25e-101049412837688
Pubmed

NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

1.14e-091149434401671
Pubmed

Retinoic acid activates two pathways required for meiosis in mice.

DAZ4 DAZ1 DAZ3 DAZ2

1.71e-091249425102060
Pubmed

ZGLP1 is a determinant for the oogenic fate in mice.

DAZ4 DAZ1 DAZ3 DAZ2

1.71e-091249432054698
InteractionSIN3B interactions

TNRC18 PHLPP1 WWTR1 SIN3A MNT

2.08e-05147465int:SIN3B
InteractionCEP55 interactions

SFPQ PTPN23 WWTR1 BAG6 GARRE1 CPSF7

2.42e-05256466int:CEP55
InteractionSNX18 interactions

BRD4 FBXO11 CPSF7 SOS2

3.48e-0581464int:SNX18
InteractionCTBP1 interactions

SFPQ ZNF219 BRD4 FBXO11 SIN3A BAG6 CPSF7

3.48e-05406467int:CTBP1
InteractionHCFC1 interactions

PRRC2C BRD4 PHLPP1 WWTR1 SIN3A KMT2E

5.15e-05293466int:HCFC1
InteractionCREBBP interactions

ATF7IP BRD4 WWTR1 ELK1 E2F5 SIN3A SRCAP SOS2

5.60e-05599468int:CREBBP
InteractionNAA40 interactions

SFPQ REPS1 NACC1 PRRC2C ATF7IP ACIN1 PTPN23 PPP1R9B SIN3A SRCAP

5.72e-059784610int:NAA40
CytobandYq11.223

DAZ4 DAZ1 DAZ3 DAZ2

3.12e-0693494Yq11.223
CytobandEnsembl 112 genes in cytogenetic band chrYq11

DAZ4 DAZ1 DAZ3 DAZ2

3.44e-04311494chrYq11
GeneFamilyRNA binding motif containing

SFPQ DAZ4 CELF3 DAZ1 DAZ3 DAZ2 CPSF7

1.45e-07213357725
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGEF11 ARHGEF16 SOS2

2.80e-0466353722
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC18 CELF3

1.06e-0325352775
GeneFamilyCyclins|F-boxes other

FBXO28 FBXO11

2.58e-0339352560
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PHLPP1 ARHGEF16 SOS2

7.30e-03206353682
CoexpressionTESAR_JAK_TARGETS_MOUSE_ES_D3_DN

DAZ4 DAZ1 DAZ3 DAZ2

5.28e-0912494MM742
CoexpressionSASAI_TARGETS_OF_CXCR6_AND_PTCH1_DN

DAZ4 DAZ1 DAZ3 DAZ2

5.28e-0912494MM781
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_DN

REPS1 DAZ4 ATF7IP MED9 FBXO11 DAZ1 ELK1 DAZ3 DAZ2 SRCAP ARHGEF11 SHISAL1

7.96e-089094912M41018
CoexpressionWAGSCHAL_EHMT2_TARGETS_UP

DAZ4 DAZ1 DAZ3 DAZ2

9.30e-0823494MM1293
CoexpressionMATZUK_SPERMATOGONIA

DAZ4 DAZ1 DAZ3 DAZ2

3.27e-0731494MM765
CoexpressionCHEN_ETV5_TARGETS_TESTIS

DAZ4 DAZ1 DAZ3 DAZ2

4.24e-0733494MM701
CoexpressionJACKSON_DNMT1_TARGETS_UP

DAZ4 DAZ1 SIN3A DAZ3 DAZ2

8.50e-0793495MM1185
CoexpressionMADAN_DPPA4_TARGETS

DAZ4 DAZ1 DAZ3 DAZ2

2.04e-0586494MM1312
CoexpressionMCCABE_BOUND_BY_HOXC6

PRR4 AMELY DAZ4 DAZ1 DAZ3 DAZ2 ARHGEF11

2.26e-05461497M6376
CoexpressionGRADE_COLON_VS_RECTAL_CANCER_DN

KMT2E MNT CPSF7

1.59e-0456493M9435
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

PRRC2C PHLPP1 TMEM131 WWTR1 E2F5 GARRE1 MNT SOS2

1.72e-04856498M4500
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_500

ZNF462 DDR1 ZNF219 CELF3 PHLPP1 SHISAL1 WNK2

8.52e-05482477Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_500
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#1_top-relative-expression-ranked_1000

ZNF462 SFPQ ACIN1 KMT2E

8.55e-05105474gudmap_developingGonad_e18.5_epididymis_1000_k1
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#5

ZNF462 DDR1 CELF3 PHLPP1 FBXO11 WNK2

1.17e-04350476Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K5
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#2_top-relative-expression-ranked_500

ZNF462 SFPQ ACIN1

1.44e-0446473gudmap_developingGonad_e12.5_epididymis_k2_500
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#1_top-relative-expression-ranked_1000

ZNF462 SFPQ ACIN1 KMT2E

1.63e-04124474gudmap_developingGonad_e16.5_epididymis_1000_k1
CoexpressionAtlasDevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#4_top-relative-expression-ranked_500

SFPQ ACIN1 KMT2E

2.20e-0453473gudmap_developingGonad_P2_epididymis_500_k4
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_1000

ZNF462 DDR1 ZNF219 REPS1 CELF3 PHLPP1 PTPN23 SHISAL1 WNK2

2.54e-04979479Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_1000
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_500

TNRC18 SFPQ PRRC2C ACIN1 SRCAP KMT2E

2.61e-04406476gudmap_developingGonad_e16.5_epididymis_500
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_500

TNRC18 SFPQ PRRC2C ACIN1 SRCAP KMT2E

2.86e-04413476gudmap_developingGonad_e14.5_ epididymis_500
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_1000

ZNF462 TNRC18 SFPQ PRRC2C ACIN1 ELK1 SRCAP KMT2E

3.08e-04790478gudmap_developingGonad_e16.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_1000

ZNF462 TNRC18 SFPQ PRRC2C ACIN1 ELK1 SRCAP KMT2E

3.38e-04801478gudmap_developingGonad_e14.5_ epididymis_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000

ZNF462 TNRC18 SFPQ PRRC2C ACIN1 SIN3A SRCAP KMT2E

3.52e-04806478gudmap_developingGonad_e12.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#2_top-relative-expression-ranked_500

SFPQ ACIN1 KMT2E

4.22e-0466473gudmap_developingGonad_e11.5_ovary + mesonephros_k2_500
CoexpressionAtlasDevelopingGonad_e11.5_testes_emap-3226_top-relative-expression-ranked_1000

ZNF462 DDR1 SFPQ PRRC2C ACIN1 KMT2E BAG6 GARRE1

4.75e-04843478gudmap_developingGonad_e11.5_testes_1000
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#5_top-relative-expression-ranked_500

SFPQ ACIN1 KMT2E

5.45e-0472473gudmap_developingGonad_e18.5_epididymis_500_k5
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SFPQ PRRC2C ATF7IP ACIN1 KMT2E

2.69e-0620049512f1685ce8f218433068e090c9d839cd5a1910bf
Drugboron trichloride

DAZ4 DAZ1 DAZ3 DAZ2

2.83e-106494CID000025135
Drugdesmethylazelastine

DAZ4 DAZ1 DAZ3 DAZ2

3.38e-0816494CID000162558
Drug2-chlorodideoxyadenosine

AMELY DAZ4 DAZ1 DAZ3 DAZ2

3.39e-0843495CID000072194
Drugdazmegrel

DAZ4 DAZ1 DAZ3 DAZ2

7.16e-0819494CID000053555
DrugYM 026

DAZ4 DAZ1 DAZ3 DAZ2

7.16e-0819494CID000004443
Drugazafagomine

AMELY DAZ4 DAZ1 DAZ3 DAZ2

1.44e-0757495CID011957435
DrugAZFd

DAZ4 DAZ1 DAZ3 DAZ2

1.63e-0723494CID000196489
Drugdansylaziridine

DAZ4 DAZ1 DAZ3 DAZ2

1.63e-0723494CID000104008
Drugd-gluconhydroximo-1,5-lactam

DAZ4 DAZ1 DAZ3 DAZ2

5.71e-0731494CID000003479
Drugp11-13

AMELY DAZ4 DAZ1 DAZ3 DAZ2

5.77e-0775495CID000015759
DrugVistar

DAZ4 DAZ1 DAZ3 DAZ2

1.06e-0636494CID000040896
Drug3-bromo-7-nitroindazole

DAZ4 DAZ1 DAZ3 DAZ2

1.06e-0636494CID000001649
Drugmolybdenum disulfide

DAZ4 DAZ1 DAZ3 DAZ2

2.20e-0643494CID000014823
Drugpropham

DAZ4 DAZ1 DAZ3 DAZ2

2.41e-0644494CID000024685
DrugCAY10397; Down 200; 10uM; PC3; HT_HG-U133A

PRR4 MED9 ELK1 SRCAP ARHGEF11 SHISAL1

4.23e-061994967071_DN
Drugridogrel

DAZ4 DAZ1 DAZ3 DAZ2

4.75e-0652494CID005362391
DrugNSC56408

DAZ4 DAZ1 DAZ3 DAZ2

9.63e-0662494CID000005604
Drugkt S

DAZ4 DAZ1 DAZ3 DAZ2

1.24e-0566494CID006399216
Drugganoine

AMELX AMELY

1.36e-053492CID000131592
Drugazelastine

DAZ4 DAZ1 DAZ3 DAZ2

1.95e-0574494CID000002267
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A

ATXN7 FBXO28 FBXO11 E2F5 SOS2

4.43e-051824953887_DN
DrugBW755C

DAZ4 DAZ1 DAZ3 DAZ2

4.80e-0593494CID000047795
Drugbipy

DAZ4 DAZ1 DAZ3 DAZ2

5.66e-0597494CID000001474
DrugFluphenazine dihydrochloride [146-56-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A

PRR4 PHLPP1 ELK1 ARHGEF11 GARRE1

6.00e-051944953194_DN
DrugZomepirac sodium salt [64092-48-4]; Down 200; 12.8uM; MCF7; HT_HG-U133A

NBEAL2 MED9 SRCAP ARHGEF11 SOS2

6.00e-051944953454_DN
DrugAG-012559 [369370-06-9]; Down 200; 10uM; PC3; HT_HG-U133A

ZNF219 BRD4 FBXO11 SHISAL1 SOS2

6.30e-051964956884_DN
DrugBucladesine sodium salt [16980-89-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A

NBEAL2 FBXO11 ELK1 GARRE1 CPSF7

6.61e-051984953483_DN
DrugTheobromine [83-67-0]; Down 200; 22.2uM; MCF7; HT_HG-U133A

E2F5 SRCAP ARHGEF11 ARHGEF16 SOS2

6.61e-051984954958_DN
DrugEstradiol-17 beta [50-28-2]; Down 200; 14.6uM; HL60; HT_HG-U133A

NBEAL2 PHLPP1 ARHGEF11 CPSF7 SOS2

6.61e-051984951299_DN
DrugBisoprolol fumarate; Down 200; 9uM; MCF7; HT_HG-U133A

ZNF219 WWTR1 SRCAP ARHGEF11 SOS2

6.61e-051984955348_DN
Drug0225151-0000 [351320-15-5]; Down 200; 10uM; PC3; HT_HG-U133A

ZNF219 MED9 FBXO11 SRCAP ARHGEF11

6.61e-051984956426_DN
Drugcarbonyl sulfide

DAZ4 DAZ1 DAZ3 DAZ2

1.14e-04116494CID000010039
DrugAC1L1D09

AMELX AMELY MNT

1.17e-0444493CID000002139
DrugTXB2 (thromboxane B2

DAZ4 DAZ1 DAZ3 DAZ2

1.21e-04118494CID000005461
Drugturimycin

DDR1 MNT

1.62e-049492CID005282189
DiseaseMale sterility due to Y-chromosome deletions

DAZ4 DAZ1 DAZ3 DAZ2

4.29e-108484C2931163
DiseasePartial chromosome Y deletion

DAZ4 DAZ1 DAZ3 DAZ2

4.29e-108484C1507149
DiseaseSpermatogenic failure, Y-linked, 2

DAZ1 DAZ3 DAZ2

2.23e-0616483cv:C1839071
DiseaseSpermatogenic Failure, Nonobstructive, Y-Linked

DAZ1 DAZ3 DAZ2

2.23e-0616483C1839071
DiseaseSPERMATOGENIC FAILURE, Y-LINKED, 2

DAZ1 DAZ3 DAZ2

2.23e-0616483415000
Diseaseamelogenesis imperfecta type 1E (implicated_via_orthology)

AMELX AMELY

2.59e-062482DOID:0110058 (implicated_via_orthology)
DiseaseIntellectual Disability

ZNF462 IQSEC3 BRD4 ACIN1 PTPN23 SIN3A KMT2E

7.52e-06447487C3714756
Diseaseautosomal dominant hypocalcemia (biomarker_via_orthology)

AMELX AMELY

1.55e-054482DOID:0090109 (biomarker_via_orthology)
Diseasebreast carcinoma (is_implicated_in)

DDR1 FBXO11

7.59e-0425482DOID:3459 (is_implicated_in)
Diseaseneuroimaging measurement, brain volume measurement

REPS1 PPP1R9B ARHGEF11 WNK2

1.20e-03286484EFO_0004346, EFO_0006930
Diseaselung non-small cell carcinoma (is_implicated_in)

DDR1 FBXO11 BAG6

1.52e-03139483DOID:3908 (is_implicated_in)
Diseasechronic kidney disease, diabetic nephropathy

REPS1 SYN2

1.58e-0336482EFO_0000401, EFO_0003884
Diseaseprostate cancer (is_marker_for)

PHLPP1 E2F5 KMT2E

2.11e-03156483DOID:10283 (is_marker_for)
Diseaseschizophrenia (is_marker_for)

PPP1R9B ELK1

2.35e-0344482DOID:5419 (is_marker_for)
DiseaseAlzheimer's disease biomarker measurement

FBXO28 WWTR1

2.79e-0348482EFO_0006514
Diseaseserum non-albumin protein measurement

REPS1 NACC1 PHLPP1 SOS2

2.81e-03361484EFO_0004568
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

SIN3A SRCAP

2.90e-0349482DOID:0060037 (implicated_via_orthology)
DiseaseHuntington's disease (is_marker_for)

ELK1 SIN3A

3.39e-0353482DOID:12858 (is_marker_for)
Diseasetestosterone measurement

DDR1 ZNF219 MED9 FBXO11 SIN3A SRCAP SOS2

4.32e-031275487EFO_0004908
DiseaseArsenic Induced Polyneuropathy

SFPQ ATXN7

4.60e-0362482C0751852
DiseaseArsenic Encephalopathy

SFPQ ATXN7

4.60e-0362482C0751851
DiseaseArsenic Poisoning

SFPQ ATXN7

4.60e-0362482C0311375

Protein segments in the cluster

PeptideGeneStartEntry
PPPPVQPPQHPRAEQ

ACIN1

1121

Q9UKV3
PVQPQPHQPMQPQPP

AMELX

131

Q99217
PPALVAQQPPPPPQQ

CELF3

346

Q5SZQ8
SLQPQPPPHPRPAVV

ELK1

166

P19419
PVQPQPHQPMQPQPP

AMELY

146

Q99218
PVHPPRPERQQQPPG

CXorf49;

466

A8MYA2
QPPPQPPAVTPEPVA

BAG6

201

P46379
PQPNPPPVQATPHPF

BRD4

211

O60885
PAPAPQPVQSHPPII

BRD4

261

O60885
PPLPPPPHPSVQQQL

BRD4

956

O60885
QPQPPPQQQHQPPPR

BRD4

981

O60885
PPPYQEPRPRGNPPH

DDR1

481

Q08345
QPQVPAPPQPRPPGH

ARHGEF16

51

Q5VV41
PVHPPPPGPREPAQQ

ARHGEF11

1091

O15085
PRPLVVNPPPPPQFQ

DAZ2

126

Q13117
PRPLVVNPPPPPQFQ

DAZ3

126

Q9NR90
PPPPVRQEPSPKPNN

CPSF7

51

Q8N684
FPAPRIGPQPQPHPQ

PTPN23

946

Q9H3S7
PPHLPSQPPQQPPQQ

FOXB2

191

Q5VYV0
PEQPRHPPQPQPQPQ

MMP24OS

31

A0A0U1RRL7
HPPQPQPQPQPQPQP

MMP24OS

36

A0A0U1RRL7
PPPPAPGPHLVQQPN

KMT2E

1631

Q8IZD2
QQPQQKTPLPAPPPP

MNT

401

Q99583
PVPPPDLQPSPPRQQ

IQSEC3

1061

Q9UPP2
QPPQPLRDPHPAPPR

ATXN7

406

O15265
PPVPAPQPQQSPAPR

MED9

36

Q9NWA0
PRPLVVNPPPPPQFQ

DAZ1

126

Q9NQZ3
PRPLVVNPPPPPQFQ

DAZ1

291

Q9NQZ3
PRPLVVNPPPPPQFQ

DAZ1

456

Q9NQZ3
QRPPPQPPQAQAPQP

E2F5

21

Q15329
PPPPPPLPQERNNVG

FBXO11

61

Q86XK2
HLLQPIGPQQPPPQP

GARRE1

736

O15063
RQPPPPAPQHPQPGS

FBXO28

31

Q9NVF7
PVHPAPLPEAPQPQR

ATF7IP

1136

Q6VMQ6
PRPLVVNPPPPPQFQ

DAZ4

126

Q86SG3
PRPLVVNPPPPPQFQ

DAZ4

291

Q86SG3
QPPLAAPPQKPQPHP

SYN2

521

Q92777
PLQHQQPPPPAGPRP

HSF5

166

Q4G112
VAHPPAVPPRPQPSQ

REPS1

581

Q96D71
QNNLAHPPAPPVPPR

SOS2

1281

Q07890
PPPLPAPADQTQPPH

NHS

71

Q6T4R5
QTPRPQPGPIPPHTQ

NBEAL2

2016

Q6ZNJ1
QPPAPIQPQSVPPPI

PRRC2C

1066

Q9Y520
IPTHGIQPQPQPPPQ

SIN3A

211

Q96ST3
IQPQPQPPPQHPSQP

SIN3A

216

Q96ST3
QPPPGPLPQAPQAVH

SHISAL1

166

Q3SXP7
PQPLGPQPVHRPNPL

SRCAP

2916

Q6ZRS2
PKPPIPPPPPHQQQQ

SFPQ

56

P23246
PPPPPHQQQQQPPPQ

SFPQ

61

P23246
PQAPPPQPTQPLQPK

TNRC18

2726

O15417
SPLEQHPQPPLPPPV

TMEM131

1296

Q92545
HPQPPLPPPVPQPQE

TMEM131

1301

Q92545
LPPPVPQPQEPQPER

TMEM131

1306

Q92545
RHPPPPPFQNQQRPP

PRR4

81

Q16378
PHQVPPQPQTQPPPT

ZNF462

571

Q96JM2
PPPPQLQPQLPRHYQ

PHLPP1

1691

O60346
PQPVVPLQPVPPHLP

WNK2

746

Q9Y3S1
ESPPHPPPQPQVCPT

nan

136

Q6ZS46
QPQPPPQPEPRSVPQ

ZNF219

231

Q9P2Y4
APPPLPPPGQQVIHV

WWTR1

6

Q9GZV5
PHQPPPPQQAPVVAA

NACC1

216

Q96RE7
QQPPQHRVAPARPPP

PPP1R9B

276

Q96SB3