Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	TOP2A TOP2B	1.45e-04	4	99	2	GO:0003918
GeneOntologyMolecularFunction	nitric-oxide synthase binding	DNM3 DNM1 DNM2	1.70e-04	22	99	3	GO:0050998
GeneOntologyMolecularFunction	protein serine/threonine kinase binding	DNM3 DNM1 DNM2	2.22e-04	24	99	3	GO:0120283
GeneOntologyMolecularFunction	D2 dopamine receptor binding	DNM1 DNM2	5.03e-04	7	99	2	GO:0031749
GeneOntologyMolecularFunction	DNA topoisomerase activity	TOP2A TOP2B	6.68e-04	8	99	2	GO:0003916
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT2B7 UGT2B28 UGT2B11	6.90e-04	35	99	3	GO:0015020
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	ARHGAP42 RANBP1 RANBP2 GRIPAP1 ARHGAP10 SIPA1L3 DLC1 RPGR ARHGEF26	9.35e-04	507	99	9	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	ARHGAP42 RANBP1 RANBP2 GRIPAP1 ARHGAP10 SIPA1L3 DLC1 RPGR ARHGEF26	9.35e-04	507	99	9	GO:0030695
GeneOntologyMolecularFunction	rDNA binding	BNC1 MTOR	1.07e-03	10	99	2	GO:0000182
GeneOntologyBiologicalProcess	biphenyl catabolic process	UGT2B7 UGT2B28 UGT2B11	5.21e-06	8	95	3	GO:0070980
GeneOntologyBiologicalProcess	biphenyl metabolic process	UGT2B7 UGT2B28 UGT2B11	1.11e-05	10	95	3	GO:0018879
GeneOntologyBiologicalProcess	synaptic vesicle budding from presynaptic endocytic zone membrane	DNM3 DNM1 DNM2	1.52e-05	11	95	3	GO:0016185
GeneOntologyBiologicalProcess	xenobiotic glucuronidation	UGT2B7 UGT2B28 UGT2B11	2.02e-05	12	95	3	GO:0052697
GeneOntologyBiologicalProcess	positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	TOP2A TOP2B	2.10e-05	2	95	2	GO:0045870
GeneOntologyBiologicalProcess	benzene-containing compound metabolic process	UGT2B7 KYAT3 UGT2B28 UGT2B11	2.48e-05	37	95	4	GO:0042537
GeneOntologyBiologicalProcess	synaptic vesicle budding	DNM3 DNM1 DNM2	4.14e-05	15	95	3	GO:0070142
GeneOntologyBiologicalProcess	vesicle scission	DNM1 DNM2	6.28e-05	3	95	2	GO:0099050
GeneOntologyBiologicalProcess	resolution of meiotic recombination intermediates	HFM1 TOP2A TOP2B	7.35e-05	18	95	3	GO:0000712
GeneOntologyBiologicalProcess	cellular glucuronidation	UGT2B7 UGT2B28 UGT2B11	1.19e-04	21	95	3	GO:0052695
GeneOntologyBiologicalProcess	glucuronate metabolic process	UGT2B7 UGT2B28 UGT2B11	2.28e-04	26	95	3	GO:0019585
GeneOntologyBiologicalProcess	uronic acid metabolic process	UGT2B7 UGT2B28 UGT2B11	2.28e-04	26	95	3	GO:0006063
Domain	Dynamin_central	DNM3 DNM1 DNM2	2.86e-06	6	99	3	IPR000375
Domain	GED	DNM3 DNM1 DNM2	2.86e-06	6	99	3	SM00302
Domain	GED	DNM3 DNM1 DNM2	2.86e-06	6	99	3	PS51388
Domain	Dynamin_M	DNM3 DNM1 DNM2	2.86e-06	6	99	3	PF01031
Domain	Dynamin_GTPase_CS	DNM3 DNM1 DNM2	2.86e-06	6	99	3	IPR019762
Domain	GED_dom	DNM3 DNM1 DNM2	2.86e-06	6	99	3	IPR020850
Domain	GED	DNM3 DNM1 DNM2	2.86e-06	6	99	3	PF02212
Domain	GED	DNM3 DNM1 DNM2	2.86e-06	6	99	3	IPR003130
Domain	G_DYNAMIN_1	DNM3 DNM1 DNM2	4.98e-06	7	99	3	PS00410
Domain	DYNc	DNM3 DNM1 DNM2	4.98e-06	7	99	3	SM00053
Domain	DNA_topoisoIV	TOP2A TOP2B	2.78e-05	2	99	2	PF00521
Domain	Topo_IIA_A/C_ab	TOP2A TOP2B	2.78e-05	2	99	2	IPR013758
Domain	Topo_IIA_A_a	TOP2A TOP2B	2.78e-05	2	99	2	IPR013757
Domain	Topo_IIA_cen_dom	TOP2A TOP2B	2.78e-05	2	99	2	IPR013759
Domain	-	TOP2A TOP2B	2.78e-05	2	99	2	3.40.50.670
Domain	DTHCT	TOP2A TOP2B	2.78e-05	2	99	2	IPR012542
Domain	TOP4c	TOP2A TOP2B	2.78e-05	2	99	2	SM00434
Domain	TOP2c	TOP2A TOP2B	2.78e-05	2	99	2	SM00433
Domain	Topo_IIA-like_dom	TOP2A TOP2B	2.78e-05	2	99	2	IPR013760
Domain	Topo_IIA_bsu_dom2	TOP2A TOP2B	2.78e-05	2	99	2	IPR013506
Domain	DTHCT	TOP2A TOP2B	2.78e-05	2	99	2	PF08070
Domain	DNA_gyraseB	TOP2A TOP2B	2.78e-05	2	99	2	PF00204
Domain	-	TOP2A TOP2B	2.78e-05	2	99	2	1.10.268.10
Domain	TOPRIM_C	TOP2A TOP2B	2.78e-05	2	99	2	IPR031660
Domain	TOPRIM_C	TOP2A TOP2B	2.78e-05	2	99	2	PF16898
Domain	-	TOP2A TOP2B	2.78e-05	2	99	2	3.90.199.10
Domain	TopoIIA_CS	TOP2A TOP2B	2.78e-05	2	99	2	IPR018522
Domain	Topo_IIA_A/C	TOP2A TOP2B	2.78e-05	2	99	2	IPR002205
Domain	Topo_IIA	TOP2A TOP2B	2.78e-05	2	99	2	IPR001241
Domain	TOPOISOMERASE_II	TOP2A TOP2B	2.78e-05	2	99	2	PS00177
Domain	G_DYNAMIN_dom	DNM3 DNM1 DNM2	5.04e-05	14	99	3	IPR030381
Domain	G_DYNAMIN_2	DNM3 DNM1 DNM2	5.04e-05	14	99	3	PS51718
Domain	Dynamin_GTPase	DNM3 DNM1 DNM2	6.28e-05	15	99	3	IPR001401
Domain	Dynamin_N	DNM3 DNM1 DNM2	6.28e-05	15	99	3	PF00350
Domain	Dynamin_SF	DNM3 DNM1 DNM2	6.28e-05	15	99	3	IPR022812
Domain	-	TOP2A TOP2B	8.32e-05	3	99	2	3.30.1360.40
Domain	Arg_repress_C-like	TOP2A TOP2B	8.32e-05	3	99	2	IPR024946
Domain	Toprim_domain	TOP2A TOP2B	1.66e-04	4	99	2	IPR006171
Domain	Toprim	TOP2A TOP2B	1.66e-04	4	99	2	PF01751
Domain	TOPRIM	TOP2A TOP2B	1.66e-04	4	99	2	PS50880
Domain	UDPGT	UGT2B7 UGT2B28 UGT2B11	1.79e-04	21	99	3	PF00201
Domain	UDPGT	UGT2B7 UGT2B28 UGT2B11	1.79e-04	21	99	3	PS00375
Domain	UDP_glucos_trans	UGT2B7 UGT2B28 UGT2B11	1.79e-04	21	99	3	IPR002213
Domain	-	ARHGAP42 RANBP1 RANBP2 ARHGAP10 FAM43B DNM3 DNM1 ARHGEF26 DNM2	2.32e-04	391	99	9	2.30.29.30
Domain	PH_dom-like	ARHGAP42 RANBP1 RANBP2 ARHGAP10 FAM43B DNM3 DNM1 ARHGEF26 DNM2	4.34e-04	426	99	9	IPR011993
Domain	PH	ARHGAP42 ARHGAP10 DNM3 DNM1 ARHGEF26 DNM2	1.38e-03	229	99	6	PF00169
Domain	Ran_BP1	RANBP1 RANBP2	1.77e-03	12	99	2	PF00638
Domain	RANBD1	RANBP1 RANBP2	1.77e-03	12	99	2	PS50196
Domain	I-BAR_dom	ARHGAP42 ARHGAP10	2.09e-03	13	99	2	IPR013606
Domain	RanBD	RANBP1 RANBP2	2.09e-03	13	99	2	SM00160
Domain	Ran_bind_dom	RANBP1 RANBP2	2.09e-03	13	99	2	IPR000156
Domain	PH	ARHGAP42 ARHGAP10 DNM3 DNM1 ARHGEF26 DNM2	3.64e-03	278	99	6	SM00233
Domain	PH_DOMAIN	ARHGAP42 ARHGAP10 DNM3 DNM1 ARHGEF26 DNM2	3.70e-03	279	99	6	PS50003
Domain	PH_domain	ARHGAP42 ARHGAP10 DNM3 DNM1 ARHGEF26 DNM2	3.77e-03	280	99	6	IPR001849
Domain	HATPase_c	TOP2A TOP2B	4.03e-03	18	99	2	SM00387
Domain	RhoGAP	ARHGAP42 ARHGAP10 DLC1	4.36e-03	62	99	3	SM00324
Domain	HATPase_c	TOP2A TOP2B	4.48e-03	19	99	2	PF02518
Domain	BAR	ARHGAP42 ARHGAP10	4.48e-03	19	99	2	PS51021
Domain	RhoGAP	ARHGAP42 ARHGAP10 DLC1	4.56e-03	63	99	3	PF00620
Domain	RHOGAP	ARHGAP42 ARHGAP10 DLC1	4.76e-03	64	99	3	PS50238
Domain	RhoGAP_dom	ARHGAP42 ARHGAP10 DLC1	4.76e-03	64	99	3	IPR000198
Domain	-	ARHGAP42 ARHGAP10 DLC1	4.76e-03	64	99	3	1.10.555.10
Domain	-	TOP2A TOP2B	4.97e-03	20	99	2	3.30.565.10
Pathway	REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING	DNM3 DNM1 DNM2	3.76e-05	14	68	3	M10122
Pathway	REACTOME_PREDNISONE_ADME	UGT2B7 UGT2B28 UGT2B11	1.77e-04	23	68	3	MM16639
Pathway	REACTOME_GLUCURONIDATION	UGT2B7 UGT2B28 UGT2B11	2.02e-04	24	68	3	MM14599
Pathway	BIOCARTA_RAN_PATHWAY	RANBP1 RANBP2	2.27e-04	5	68	2	M22082
Pathway	REACTOME_GLUCURONIDATION	UGT2B7 UGT2B28 UGT2B11	2.29e-04	25	68	3	M17787
Pathway	WP_GLUCURONIDATION	UGT2B7 UGT2B28 UGT2B11	2.29e-04	25	68	3	MM15820
Pathway	KEGG_ASCORBATE_AND_ALDARATE_METABOLISM	UGT2B7 UGT2B28 UGT2B11	2.29e-04	25	68	3	M605
Pathway	WP_GLUCURONIDATION	UGT2B7 UGT2B28 UGT2B11	2.58e-04	26	68	3	M39404
Pathway	KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	UGT2B7 UGT2B28 UGT2B11	3.23e-04	28	68	3	M19580
Pubmed	Dynamin and endocytosis.	DNM3 DNM1 DNM2	2.60e-08	3	104	3	12383797
Pubmed	Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain- and dynamin-dependent endocytosis and lysosomal targeting.	DNM3 DNM1 DNM2	2.60e-08	3	104	3	24273169
Pubmed	Dynamin: characteristics, mechanism of action and function.	DNM3 DNM1 DNM2	2.60e-08	3	104	3	12511974
Pubmed	Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis.	DNM3 DNM1 DNM2	2.60e-08	3	104	3	28395327
Pubmed	Dynamin at the actin-membrane interface.	DNM3 DNM1 DNM2	2.60e-08	3	104	3	12517701
Pubmed	Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors.	DNM3 DNM1 DNM2	2.60e-08	3	104	3	24046449
Pubmed	Overlapping role of dynamin isoforms in synaptic vesicle endocytosis.	DNM3 DNM1 DNM2	1.04e-07	4	104	3	21689597
Pubmed	Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells.	DNM3 DNM1 DNM2	1.04e-07	4	104	3	22846998
Pubmed	Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER.	DNM3 DNM1 DNM2	2.59e-07	5	104	3	9722593
Pubmed	Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons.	DNM3 DNM1 DNM2	5.16e-07	6	104	3	23640057
Pubmed	Dynamin 1- and 3-Mediated Endocytosis Is Essential for the Development of a Large Central Synapse In Vivo.	DNM3 DNM1 DNM2	5.16e-07	6	104	3	27251629
Pubmed	A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission.	DNM3 DNM1 DNM2	5.16e-07	6	104	3	18602423
Pubmed	Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.	UGT2B7 UGT2B28 UGT2B11	9.01e-07	7	104	3	26074487
Pubmed	A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.	DNM3 DNM1 DNM2	9.01e-07	7	104	3	15252009
Pubmed	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.	UGT2B7 UGT2B28 UGT2B11	1.44e-06	8	104	3	32093886
Pubmed	Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.	DNM3 DNM1 DNM2	1.44e-06	8	104	3	24282027
Pubmed	Major histocompatibility complex class-II molecules promote targeting of human immunodeficiency virus type 1 virions in late endosomes by enhancing internalization of nascent particles from the plasma membrane.	DNM3 DNM1 DNM2	2.15e-06	9	104	3	23170932
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RANBP2 TOP2A TOP2B	2.15e-06	9	104	3	18394993
Pubmed	NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.	NLRP4 TOP2A DDX4 TOP2B	2.54e-06	32	104	4	38060382
Pubmed	Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation.	DNM3 DNM1 DNM2	3.07e-06	10	104	3	10398046
Pubmed	Protein partners of dynamin-1 in the retina.	DNM3 DNM1 DNM2	3.07e-06	10	104	3	23746204
Pubmed	Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.	NSD1 RIOK3 MTF1	7.27e-06	13	104	3	16093251
Pubmed	DNA topoisomerase II is dispensable for oocyte meiotic resumption but is essential for meiotic chromosome condensation and separation in mice.	TOP2A TOP2B	8.86e-06	2	104	2	24048577
Pubmed	Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.	TOP2A TOP2B	8.86e-06	2	104	2	1309226
Pubmed	Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.	TOP2A TOP2B	8.86e-06	2	104	2	19222228
Pubmed	Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells.	TOP2A TOP2B	8.86e-06	2	104	2	2555055
Pubmed	Characterization of cDNA encoding the mouse DNA topoisomerase II that can complement the budding yeast top2 mutation.	TOP2A TOP2B	8.86e-06	2	104	2	1331984
Pubmed	Classical dynamin DNM1 and DNM3 genes attain maximum expression in the normal human central nervous system.	DNM3 DNM1	8.86e-06	2	104	2	24673776
Pubmed	Doxorubicin-induced cardiotoxicity is maturation dependent due to the shift from topoisomerase IIα to IIβ in human stem cell derived cardiomyocytes.	TOP2A TOP2B	8.86e-06	2	104	2	31106979
Pubmed	A biochemical analysis of topoisomerase II alpha and beta kinase activity found in HIV-1 infected cells and virus.	TOP2A TOP2B	8.86e-06	2	104	2	16091284
Pubmed	Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation.	DNM1 DNM2	8.86e-06	2	104	2	21670293
Pubmed	Differential appearance of dynamin in constitutive and regulated exo-endocytosis: a single-cell multiplex RT-PCR study.	DNM1 DNM2	8.86e-06	2	104	2	16028072
Pubmed	Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa.	DNM1 DNM2	8.86e-06	2	104	2	22977254
Pubmed	Kinetic analysis of human topoisomerase IIalpha and beta DNA binding by surface plasmon resonance.	TOP2A TOP2B	8.86e-06	2	104	2	14596941
Pubmed	Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.	TOP2A TOP2B	8.86e-06	2	104	2	17361331
Pubmed	Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication.	TOP2A TOP2B	8.86e-06	2	104	2	10095062
Pubmed	Functional compatibility between isoform alpha and beta of type II DNA topoisomerase.	TOP2A TOP2B	8.86e-06	2	104	2	14996935
Pubmed	Structural organization of the human TOP2A and TOP2B genes.	TOP2A TOP2B	8.86e-06	2	104	2	9795238
Pubmed	The distribution of DNA topoisomerase II isoforms in differentiated adult mouse tissues.	TOP2A TOP2B	8.86e-06	2	104	2	8241259
Pubmed	Mining topoisomerase isoforms in gastric cancer.	TOP2A TOP2B	8.86e-06	2	104	2	32535049
Pubmed	Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development.	TOP2A TOP2B	8.86e-06	2	104	2	1380833
Pubmed	Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells.	TOP2A TOP2B	8.86e-06	2	104	2	11927602
Pubmed	Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells.	TOP2A TOP2B	8.86e-06	2	104	2	17182034
Pubmed	Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients.	DNM3 DNM1	8.86e-06	2	104	2	20700106
Pubmed	Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons.	TOP2A TOP2B	8.86e-06	2	104	2	28700616
Pubmed	Predictors and mechanisms of epilepsy occurrence in cerebral gliomas: What to look for in clinicopathology.	TOP2A TOP2B	8.86e-06	2	104	2	28087392
Pubmed	Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint.	TOP2A TOP2B	8.86e-06	2	104	2	28472494
Pubmed	Dynamin is primed at endocytic sites for ultrafast endocytosis.	DNM3 DNM1	8.86e-06	2	104	2	35809574
Pubmed	The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3.	DNM3 DNM1	8.86e-06	2	104	2	38641407
Pubmed	Association of immunophenotype with expression of topoisomerase II α and β in adult acute myeloid leukemia.	TOP2A TOP2B	8.86e-06	2	104	2	32218491
Pubmed	Dynamin-mediated lipid acquisition is essential for Chlamydia trachomatis development.	DNM1 DNM2	8.86e-06	2	104	2	25116793
Pubmed	Dynamin regulates L cell secretion in human gut.	DNM1 DNM2	8.86e-06	2	104	2	34274446
Pubmed	Involvement of human topoisomerase II isoforms in HIV-1 reverse transcription.	TOP2A TOP2B	8.86e-06	2	104	2	23399433
Pubmed	Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study.	UGT2B28 UGT2B11	8.86e-06	2	104	2	21679149
Pubmed	Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2.	TOP2A TOP2B	8.86e-06	2	104	2	30169847
Pubmed	Enhanced processing of UVA-irradiated DNA by human topoisomerase II in living cells.	TOP2A TOP2B	8.86e-06	2	104	2	15044480
Pubmed	C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.	TOP2A TOP2B	8.86e-06	2	104	2	17526531
Pubmed	Dynamin at actin tails.	DNM1 DNM2	8.86e-06	2	104	2	11782545
Pubmed	A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis.	DNM3 DNM1	8.86e-06	2	104	2	24963135
Pubmed	The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.	TOP2A TOP2B	8.86e-06	2	104	2	9155056
Pubmed	DNA topoisomerase II distribution in mouse preimplantation embryos.	TOP2A TOP2B	8.86e-06	2	104	2	11835579
Pubmed	Crystal structure of the dynamin tetramer.	DNM3 DNM1	8.86e-06	2	104	2	26302298
Pubmed	Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses.	DNM3 DNM1	8.86e-06	2	104	2	22308498
Pubmed	Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes.	TOP2A TOP2B	8.86e-06	2	104	2	2556712
Pubmed	A study of the topoisomerase II activity in HIV-1 replication using the ferrocene derivatives as probes.	TOP2A TOP2B	8.86e-06	2	104	2	16712776
Pubmed	Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms.	TOP2A TOP2B	8.86e-06	2	104	2	8710863
Pubmed	Dynamin 2-dependent endocytosis is essential for mouse oocyte development and fertility.	DNM1 DNM2	8.86e-06	2	104	2	32065700
Pubmed	Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon.	TOP2A TOP2B	8.86e-06	2	104	2	26612825
Pubmed	Using a biochemical approach to identify the primary dimerization regions in human DNA topoisomerase IIalpha.	TOP2A TOP2B	8.86e-06	2	104	2	10473615
Pubmed	An intramolecular signaling element that modulates dynamin function in vitro and in vivo.	DNM1 DNM2	8.86e-06	2	104	2	19515832
Pubmed	Cellular distribution of mammalian DNA topoisomerase II is determined by its catalytically dispensable C-terminal domain.	TOP2A TOP2B	8.86e-06	2	104	2	9224616
Pubmed	DNA damage response during chromatin remodeling in elongating spermatids of mice.	TOP2A TOP2B	8.86e-06	2	104	2	18032420
Pubmed	Discrete localization of different DNA topoisomerases in HeLa and K562 cell nuclei and subnuclear fractions.	TOP2A TOP2B	8.86e-06	2	104	2	8299728
Pubmed	Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.	TOP2A TOP2B	8.86e-06	2	104	2	22111588
Pubmed	Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.	TOP2A TOP2B	8.86e-06	2	104	2	17578914
Pubmed	Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.	SYCP2 NLRP4 DDX4	9.23e-06	14	104	3	21079677
Pubmed	Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation.	DNM3 DNM1 DNM2	9.23e-06	14	104	3	20802490
Pubmed	EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts.	DNM3 DNM1 DNM2	1.71e-05	17	104	3	37042948
Pubmed	Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.	GART CREBBP USP5 DNM3 TOP2A TOP2B	1.76e-05	180	104	6	30110629
Pubmed	Functional dynamics of H3K9 methylation during meiotic prophase progression.	KDM3A PTGDS DDX4	2.43e-05	19	104	3	17599069
Pubmed	Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1.	TOP2A TOP2B	2.65e-05	3	104	2	17567603
Pubmed	Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis.	TOP2A TOP2B	2.65e-05	3	104	2	11136718
Pubmed	Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane.	DNM1 DNM2	2.65e-05	3	104	2	22371560
Pubmed	Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).	TOP2A TOP2B	2.65e-05	3	104	2	24808172
Pubmed	Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta.	TOP2A TOP2B	2.65e-05	3	104	2	12821127
Pubmed	Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase.	DNM1 DNM2	2.65e-05	3	104	2	15895076
Pubmed	Adipose-Derived VEGF-mTOR Signaling Promotes Endometrial Hyperplasia and Cancer: Implications for Obese Women.	ALMS1 MTOR	2.65e-05	3	104	2	29133593
Pubmed	Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9.	DNM3 DNM1	2.65e-05	3	104	2	35065714
Pubmed	DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.	TOP2A TOP2B	2.65e-05	3	104	2	23466610
Pubmed	Two distinct classes of Ran-binding sites on the nucleoporin Nup-358.	RANBP1 RANBP2	2.65e-05	3	104	2	10318915
Pubmed	SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.	DNM1 DNM2	2.65e-05	3	104	2	15703209
Pubmed	Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53.	TOP2A TOP2B	2.65e-05	3	104	2	10666337
Pubmed	TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage.	TERF2 TOP2A	2.65e-05	3	104	2	20655466
Pubmed	Nucleophagy contributes to genome stability through degradation of type II topoisomerases A and B and nucleolar components.	TOP2A TOP2B	2.65e-05	3	104	2	36633090
Pubmed	Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage.	TOP2A TOP2B	2.65e-05	3	104	2	16611985
Pubmed	Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes.	DNM1 DNM2	2.65e-05	3	104	2	24145164
Pubmed	The Expression of Dynamin 1, 2, and 3 in Human Hepatocellular Carcinoma and Patient Prognosis.	DNM3 DNM2	2.65e-05	3	104	2	32573516
Pubmed	The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling.	DNM1 DNM2	2.65e-05	3	104	2	11483962
Pubmed	Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities.	TOP2A TOP2B	2.65e-05	3	104	2	9049244
Pubmed	The atypical protein kinase RIOK3 contributes to glioma cell proliferation/survival, migration/invasion and the AKT/mTOR signaling pathway.	RIOK3 MTOR	2.65e-05	3	104	2	29233656
Interaction	SCN2B interactions	RNF213 MTOR DNM3 DNM1 CNOT1 DNM2	8.75e-06	95	102	6	int:SCN2B
GeneFamily	Neuroblastoma breakpoint family	NBPF8 NBPF12 NBPF11	7.81e-05	23	66	3	662
GeneFamily	Topoisomerases	TOP2A TOP2B	1.95e-04	6	66	2	1050
GeneFamily	UDP glucuronosyltransferases	UGT2B7 UGT2B28 UGT2B11	2.14e-04	32	66	3	363
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP42 ARHGAP10 DLC1	8.06e-04	50	66	3	721
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	PSTPIP2 TRIP10	3.16e-03	23	66	2	1288
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF777 ZNF658 ZSCAN26 ZNF267 BNC1 ZNF770 ZNF471 ZNF415	4.47e-03	718	66	8	28
Coexpression	GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_16H_UP	CDKN3 MMS22L AATK CSF2RA PUS10 KYAT3 TOP2A	1.31e-05	199	102	7	M8266
Coexpression	GSE40666_WT_VS_STAT1_KO_CD8_TCELL_WITH_IFNA_STIM_90MIN_DN	MMS22L RNF213 PSTPIP2 GTF3C1 ALMS1 PUS10 TOP2A	1.36e-05	200	102	7	M9215
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	ARHGAP42 OXR1 ARID4A CREBBP ALMS1 ZNF770	4.99e-06	186	104	6	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Pericytes\|Fibroblasts / Location, Cell class and cell subclass	ARHGAP42 UACA ARHGAP10 COL14A1 RPGR CABIN1	5.47e-06	189	104	6	f4865b7db16de15120504147a8016ac522ad242a
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area\|World / Primary Cells by Cluster	GPR22 ARID4A DLC1 CAMKV DNM3 XPR1	6.94e-06	197	104	6	79b9e7f2e8e33b3c547f716be5667156c48b0dfc
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area-33\|World / Primary Cells by Cluster	GPR22 ARID4A DLC1 CAMKV DNM3 XPR1	6.94e-06	197	104	6	d20f29088e9afd8a960d6f680075c380e550f8a7
Drug	Menthol	UGT2B7 TRPM8 UGT2B11 TOP2A TOP2B	1.55e-07	28	103	5	ctd:D008610
Drug	Go7874	DNM3 DNM1 DNM2	1.92e-05	12	103	3	CID005327863
Drug	2-hydroxyestriol	UGT2B7 UGT2B11	2.03e-05	2	103	2	ctd:C008012
Drug	Dexrazoxane	TOP2A TOP2B	2.03e-05	2	103	2	DB00380
Drug	F14512	TOP2A TOP2B	2.03e-05	2	103	2	ctd:C534191
Drug	Daunorubicin	TOP2A TOP2B	2.03e-05	2	103	2	DB00694
Drug	Troleandomycin [2751-09-9]; Up 200; 5uM; HL60; HG-U133A	PTGDS TRIP10 GTF3C1 ALMS1 DYNC2LI1 TRABD DNM2	3.31e-05	198	103	7	1965_UP
Drug	Isoxsuprine hydrochloride [579-56-6]; Up 200; 11.8uM; HL60; HG-U133A	ARID4A ARHGAP10 PTGDS TRIP10 AATK GTF3C1 DNM1	3.31e-05	198	103	7	1985_UP
Disease	acute myeloid leukemia (implicated_via_orthology)	ARID4A CREBBP TOP2A TOP2B	5.78e-08	12	99	4	DOID:9119 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease dominant intermediate B (implicated_via_orthology)	DNM3 DNM1 DNM2	3.65e-07	5	99	3	DOID:0110197 (implicated_via_orthology)
Disease	centronuclear myopathy 1 (implicated_via_orthology)	DNM3 DNM1 DNM2	3.65e-07	5	99	3	DOID:0111223 (implicated_via_orthology)
Disease	microcytic anemia (implicated_via_orthology)	DNM3 DNM1 DNM2	3.65e-07	5	99	3	DOID:11252 (implicated_via_orthology)
Disease	collagen disease (implicated_via_orthology)	DNM3 DNM1 DNM2	7.88e-06	12	99	3	DOID:854 (implicated_via_orthology)
Disease	developmental and epileptic encephalopathy (implicated_via_orthology)	DNM3 DNM1 DNM2	1.02e-05	13	99	3	DOID:0112202 (implicated_via_orthology)
Disease	B cell deficiency (implicated_via_orthology)	TOP2A TOP2B	1.11e-05	2	99	2	DOID:2115 (implicated_via_orthology)
Disease	X-linked mental retardation with cerebellar hypoplasia and distinctive facial appearance (implicated_via_orthology)	ARHGAP42 ARHGAP10	6.66e-05	4	99	2	DOID:0080311 (implicated_via_orthology)
Disease	urinary metabolite measurement	LACTB ALMS1 UGT2B7 KYAT3 UGT2B11 CABIN1	1.81e-04	245	99	6	EFO_0005116
Disease	Adenoid Cystic Carcinoma	NSD1 CREBBP FGF16 TOP2A	3.65e-04	100	99	4	C0010606
Disease	plasma clozapine-to-N-desmethylclozapine ratio measurement	UGT2B7 UGT2B11	3.95e-04	9	99	2	EFO_0600040
Disease	hereditary spastic paraplegia (implicated_via_orthology)	DNM3 DNM1 DNM2	4.10e-04	43	99	3	DOID:2476 (implicated_via_orthology)
Disease	metabolite measurement	FAM47A LACTB PM20D2 ALMS1 UGT2B7 KYAT3 UGT2B11 CABIN1	6.04e-04	560	99	8	EFO_0004725
Disease	ovarian carcinoma	FAM47A KDM3A MMS22L DLC1 DNM3 MVB12B	7.59e-04	321	99	6	EFO_0001075
Disease	imidazole lactate measurement	KYAT3 CNOT1	8.48e-04	13	99	2	EFO_0800004
Disease	X-19141 measurement	UGT2B7 UGT2B11	8.48e-04	13	99	2	EFO_0800799
Disease	phosphatidylcholine 36:4 measurement	UGT2B28 UGT2B11	1.65e-03	18	99	2	EFO_0010382
Disease	syndrome (implicated_via_orthology)	NSD1 CNOT1	1.65e-03	18	99	2	DOID:225 (implicated_via_orthology)
Disease	colorectal cancer, inflammatory bowel disease	PTCHD3 ALMS1	1.84e-03	19	99	2	EFO_0003767, MONDO_0005575
Disease	X-24947 measurement	UGT2B7 UGT2B11	2.46e-03	22	99	2	EFO_0800910
Disease	response to mTOR inhibitor	USP32 MVB12B	3.18e-03	25	99	2	EFO_0005417

Protein segments in the cluster

Peptide	Gene	Start	Entry
VKKDQCLVRSFIDSK	ARID4A	206	P29374
KKRDEVICRFIFNES	ANTXRL	281	A6NF34
KFKRNDDECRAFVKR	CATSPER3	31	Q86XQ3
KKADFIATFLCQEKI	DDX4	551	Q9NQI0
EENRFQCDICKKTFK	BNC1	716	Q01954
DISFIQSKKVVCFKE	ALMS1	2291	Q8TCU4
KFCSKLAEVFEQEID	CREBBP	1176	Q92793
IVKFRDKVSCVEFDL	TENT2	266	Q6PIY7
NITDVCEASKKFFIE	ARHGEF26	486	Q96DR7
TSICKKFFKEEIRSD	DIPK2B	66	Q9H7Y0
AVRFKTKEVADCFKK	RANBP2	3021	P49792
ENAQKFKTKFEECRK	RANBP1	146	P43487
FKTKFEECRKEIEER	RANBP1	151	P43487
RFKEKENSECAFRVL	NSD1	1176	Q96L73
GRKNCKEFEDFLKER	PSTPIP2	31	Q9H939
KTVCEDVFQVAKAEF	MPEG1	446	Q2M385
EAKNYFAKVDCKERI	ANAPC5	696	Q9UJX4
YVCKLQEIQERKKFE	ARHGAP10	181	A1A4S6
VVIQKSRAEKDCLFA	PARP8	16	Q8N3A8
KAKREAAKEICSEFR	SPINK5	486	Q9NQ38
LAEKFSCAFREKAKE	MMS22L	591	Q6ZRQ5
SCAFREKAKEFLVSK	MMS22L	596	Q6ZRQ5
CKGKKFTDFEEVRLE	DNM1	86	Q05193
RNKFVLVEDEAKCKA	FAM43B	6	Q6ZT52
DFTKFKTEQENEAKC	LACTB	261	P83111
FQDFESEKRKVICKT	DYNC2LI1	191	Q8TCX1
CKGKKFTDFDEVRLE	DNM3	86	Q9UQ16
LEEFCKELAAIAFVK	FHIP2B	711	Q86V87
KMAFFQCREEVEKVK	MYLK4	21	Q86YV6
KLCFSVQNVFKKEDE	NLRP4	601	Q96MN2
IVADSVRFQVDKCFK	OVOS2	531	Q6IE36
CKSKKFTDFDEVRQE	DNM2	86	P50570
LFNFIRKNKDKFDCI	PHOSPHO2	81	Q8TCD6
RKNKDKFDCIIISDS	PHOSPHO2	86	Q8TCD6
VDRETDEFFKKCRVI	SLC9A3R1	231	O14745
TQEVAFRKKRLCIKF	MVB12B	136	Q9H7P6
RKKFLCVTKEQEFLQ	KBTBD8	176	Q8NFY9
KVDFFIRNSECKKEV	HFM1	1396	A2PYH4
EEEAFTEKFLKINCK	OXR1	206	Q8N573
EKDFIKKVCQKVEAS	PUS10	121	Q3MIT2
KDKEQQKDSPVFCRF	KDM3A	556	Q9Y4C1
RVRNTKCKKEEKVDF	CABIN1	396	Q9Y6J0
KTEEFCEIFRAKDKT	CAMKV	31	Q8NCB2
FTIDRCAKDLFVAKQ	DMRT2	516	Q9Y5R5
FKCNEEAKIFLKDIA	CCDC175	61	P0C221
KEEIRRCIQDFFKKH	CDC123	206	O75794
KLNFDDFCIILRKEK	EFCAB7	86	A8K855
DAFKKIEDELITFVC	COL14A1	1196	Q05707
DKKFLAEAAIRFECV	TMEM63B	546	Q5T3F8
LKKCFEGIAKVEFTE	DNAH7	1096	Q8WXX0
RATHEDQKFKKVKEC	FAM47A	636	Q5JRC9
EVHFKNKEEPRKVCF	MLLT1	86	Q03111
FKEIFLEIDKQCKFD	CUZD1	196	Q86UP6
NKKITFEDSEIREKC	GPR22	411	Q99680
KKKQESFCRLQTEKE	GRIPAP1	236	Q4V328
CKFKDVRRNVQKDTE	CDKN3	51	Q16667
EKDLFKFLEELKRCN	EFCAB3	216	Q8N7B9
KFVRFCFIKKDSTLD	KYAT3	426	Q6YP21
TFSKCFLTDKKNRVV	CSF2RA	56	P15509
DVRQKLENCTKIFEK	PTCHD3	671	Q3KNS1
FRNEFEKICRKEVKP	PHYH	81	O14832
LSCVKKEKERTAAFQ	MTOR	421	P42345
VKKRESCKQDVIFDS	RPGR	691	Q92834
FQKLKEEQRCFDIEK	SPEF2	181	Q9C093
LFTCFKRNDKREVKV	TOP2B	751	Q02880
FCEDLERKKKAVSFF	AATK	1221	Q6ZMQ8
EKKQQFRSLKEKCFV	NBPF8	266	Q3BBV2
EKKQQFRSLKEKCFV	NBPF11	301	Q86T75
EKKQQFRSLKEKCFV	NBPF12	301	Q5TAG4
AEKKQQFRSLKEKCF	NBPF12	571	Q5TAG4
KTDSIDKRFCFDIEV	ARHGAP42	331	A6NI28
ETKRKEVKRYQCTFE	MTF1	131	Q14872
CDKIEAKFDKEFQAL	NAP1L5	91	Q96NT1
SKKLTRECVFREQFE	FGF16	126	O43320
RAELKEKFTAFCKAQ	PTGDS	156	P41222
KKRLREFVFCNKTQS	MRPL35	141	Q9NZE8
QLRKFAEIFCREKKE	SIPA1L3	1766	O60292
EKVKKALAQVFCEES	SCFD2	496	Q8WU76
QDCVDGLFKEVKEKF	DLC1	1326	Q96QB1
KELQVLTKKAEDCFR	PM20D2	281	Q8IYS1
FKQLENSKRKFERDC	TRIP10	131	Q15642
KNCYKDFLEITERAK	C10orf82	131	Q8WW14
FKDSTIKREREVFNC	CNOT1	876	A5YKK6
ECAIKVFKTTLNEFK	RIOK3	286	O14730
FAKFEEKFFQTCEKE	XPR1	51	Q9UBH6
EKFFQTCEKELAKIN	XPR1	56	Q9UBH6
AKAYETVCKRQDKEF	RNF213	2936	Q63HN8
NDRKKFCKNAEEFTK	UBE2L5	131	A0A1B0GUS4
FREAFKEASKVPFCK	TRABD	171	Q9H4I3
EDVKIKCSKQFFHKV	SYCP2	36	Q9BX26
EKQYKCKEFEEVFLQ	ZNF267	241	Q14586
KKSRFDKLEEFCNLI	REP15	141	Q6BDI9
DIFRNFCKDVVSNKK	UGT2B11	121	O75310
TALAQFCKEKKIEFV	GART	56	P22102
SEKKVFKKSFLRNCD	ZNF770	356	Q6IQ21
FEECERKFKATEKEL	UACA	991	Q9BZF9
KSCKDDEFRKNFDKI	ZNF658	241	Q5TYW1
KEKIEYKCSEREQRF	ZSCAN26	226	Q16670
FTCFKRNDKREVKVA	TOP2A	731	P11388
LFECKECRKAFKQSE	ZNF471	261	Q9BX82
KHDIEEFCFREIKKK	ZNF415	126	Q09FC8
QANFKKRECVFFTKD	TRPM8	46	Q7Z2W7
KRECVFFTKDSKATE	TRPM8	51	Q7Z2W7
DIFRNFCKDVVSNKK	UGT2B28	121	Q9BY64
DITRKFCKDVVSNKK	UGT2B7	121	P16662
KVCANEFKEFVEKLK	GTF3C1	1361	Q12789
NEKKIADCEKTAVEF	ZNF777	216	Q9ULD5
EAAVIICIKNKEFEK	TERF2	201	Q15554
FRFLVEEKIKCLATE	USP5	461	P45974
AERQKFCFKVFDVDR	USP32	266	Q8NFA0
EKLVARKVCVAFKQT	PPIP5K1	301	Q6PFW1
KETCISFIKDFLAKN	TSPAN8	191	P19075