Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP1 LRP2 LRP1B

3.50e-0616383GO:0005041
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP1 LRP2 LRP1B

8.26e-0621383GO:0030228
GeneOntologyMolecularFunctioncargo receptor activity

LRP1 LRP2 MRC1 LRP1B

2.02e-0585384GO:0038024
GeneOntologyMolecularFunctionmuscle alpha-actinin binding

PRICKLE4 PDLIM7

3.65e-0415382GO:0051371
GeneOntologyMolecularFunctionnuclear receptor binding

LRP2 NSD1 ISL1 KDM5D

4.29e-04187384GO:0016922
GeneOntologyMolecularFunctioncalcium ion binding

LRP1 LRP2 MACF1 EYS FBN1 LRP1B NOTCH1

4.64e-04749387GO:0005509
GeneOntologyMolecularFunctionprotein-cysteine S-palmitoyltransferase activity

ZDHHC5 ZDHHC8

1.11e-0326382GO:0019706
GeneOntologyMolecularFunctionprotein-cysteine S-acyltransferase activity

ZDHHC5 ZDHHC8

1.11e-0326382GO:0019707
GeneOntologyMolecularFunctionS-acyltransferase activity

ZDHHC5 ZDHHC8

1.48e-0330382GO:0016417
GeneOntologyMolecularFunctionalpha-actinin binding

PRICKLE4 PDLIM7

1.58e-0331382GO:0051393
GeneOntologyMolecularFunctionnuclear androgen receptor binding

NSD1 KDM5D

1.79e-0333382GO:0050681
GeneOntologyMolecularFunctionpalmitoyltransferase activity

ZDHHC5 ZDHHC8

2.25e-0337382GO:0016409
GeneOntologyMolecularFunctionlipoprotein particle receptor binding

LRP1 LRP2

2.50e-0339382GO:0070325
GeneOntologyMolecularFunctionchromatin binding

NSD1 ATRN ISL1 PHF19 OBI1 NOTCH1

2.53e-03739386GO:0003682
GeneOntologyMolecularFunctionactinin binding

PRICKLE4 PDLIM7

3.03e-0343382GO:0042805
GeneOntologyMolecularFunctionprotein-folding chaperone binding

LRP2 VWF TG

3.53e-03161383GO:0051087
GeneOntologyMolecularFunctionnuclear estrogen receptor binding

NSD1 ISL1

4.57e-0353382GO:0030331
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

LRP2 NSD1 ISL1 KDM5D NLRP3

4.69e-03582385GO:0140297
GeneOntologyMolecularFunctionextracellular matrix structural constituent

FBN1 VWF SSPOP

5.44e-03188383GO:0005201
GeneOntologyBiologicalProcessaxonogenesis

LRP1 LRP2 MACF1 LIMK1 ISL1 NIBAN2 MYCBP2 LMX1A NOTCH1

1.06e-06566409GO:0007409
GeneOntologyBiologicalProcessaxon guidance

LRP1 LRP2 ISL1 NIBAN2 MYCBP2 LMX1A NOTCH1

1.13e-06285407GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

LRP1 LRP2 ISL1 NIBAN2 MYCBP2 LMX1A NOTCH1

1.15e-06286407GO:0097485
GeneOntologyBiologicalProcessaxon development

LRP1 LRP2 MACF1 LIMK1 ISL1 NIBAN2 MYCBP2 LMX1A NOTCH1

2.99e-06642409GO:0061564
GeneOntologyBiologicalProcessregulation of BMP signaling pathway

VWC2L LRP2 KCP FBN1 NOTCH1

5.27e-06131405GO:0030510
GeneOntologyBiologicalProcessnegative regulation of cellular response to growth factor stimulus

VWC2L LRP2 NIBAN2 FBN1 NOTCH1

1.02e-05150405GO:0090288
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

LRP1 LRP2 MACF1 LIMK1 ISL1 NIBAN2 MYCBP2 LMX1A NOTCH1

1.03e-05748409GO:0048667
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

LRP1 VWC2L LRP2 KCP NIBAN2 FBN1 NOTCH1

1.27e-05412407GO:0090287
GeneOntologyBiologicalProcesstranscytosis

LRP1 LRP2 TG

1.33e-0524403GO:0045056
GeneOntologyBiologicalProcessnegative regulation of BMP signaling pathway

VWC2L LRP2 FBN1 NOTCH1

1.72e-0580404GO:0030514
GeneOntologyBiologicalProcessneuron projection morphogenesis

LRP1 LRP2 MACF1 LIMK1 ISL1 NIBAN2 MYCBP2 LMX1A NOTCH1

1.79e-05802409GO:0048812
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

LRP1 LRP2 MACF1 LIMK1 ISL1 NIBAN2 MYCBP2 LMX1A NOTCH1

2.12e-05819409GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

LRP1 LRP2 MACF1 LIMK1 ISL1 NIBAN2 MYCBP2 LMX1A NOTCH1

2.27e-05826409GO:0048858
GeneOntologyBiologicalProcesspositive regulation of lysosomal protein catabolic process

LRP1 LRP2

3.65e-055402GO:1905167
GeneOntologyBiologicalProcesschemoattraction of axon

LRP1 LRP2

3.65e-055402GO:0061642
GeneOntologyBiologicalProcessBMP signaling pathway

VWC2L LRP2 KCP FBN1 NOTCH1

3.79e-05197405GO:0030509
GeneOntologyBiologicalProcessheart formation

LRP2 ISL1 NOTCH1

4.61e-0536403GO:0060914
GeneOntologyBiologicalProcesspositive regulation of cell differentiation

LRP1 VWC2L LRP2 MACF1 LIMK1 ISL1 NIBAN2 PDLIM7 NOTCH1 NLRP3

4.77e-0511414010GO:0045597
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

LRP1 VWC2L LRP2 KCP FBN1 NOTCH1

5.14e-05347406GO:0090092
GeneOntologyBiologicalProcessresponse to BMP

VWC2L LRP2 KCP FBN1 NOTCH1

5.74e-05215405GO:0071772
GeneOntologyBiologicalProcesscellular response to BMP stimulus

VWC2L LRP2 KCP FBN1 NOTCH1

5.74e-05215405GO:0071773
GeneOntologyBiologicalProcessnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

LRP1 VWC2L LRP2 FBN1 NOTCH1

6.13e-05218405GO:0090101
GeneOntologyBiologicalProcessneuron development

LRP1 LRP2 MACF1 LIMK1 ISL1 NIBAN2 LTK MYCBP2 LMX1A LMX1B NOTCH1

7.47e-0514634011GO:0048666
GeneOntologyBiologicalProcesspositive regulation of protein catabolic process in the vacuole

LRP1 LRP2

7.65e-057402GO:1904352
GeneOntologyBiologicalProcessdopaminergic neuron differentiation

LMX1A LMX1B WNT9B

1.24e-0450403GO:0071542
GeneOntologyBiologicalProcessregulation of neuron differentiation

VWC2L ISL1 LTK LMX1A NOTCH1

1.28e-04255405GO:0045664
GeneOntologyBiologicalProcessneuron projection development

LRP1 LRP2 MACF1 LIMK1 ISL1 NIBAN2 LTK MYCBP2 LMX1A NOTCH1

1.29e-0412854010GO:0031175
GeneOntologyBiologicalProcesscardiac septum development

LRP1 LRP2 ISL1 NOTCH1

1.30e-04134404GO:0003279
GeneOntologyBiologicalProcessregulation of developmental growth

LRP1 ATRN MACF1 LIMK1 MYCBP2 NOTCH1

1.49e-04421406GO:0048638
GeneOntologyBiologicalProcesspositive regulation of cell development

LRP1 LRP2 MACF1 LIMK1 NIBAN2 NOTCH1 NLRP3

1.59e-04614407GO:0010720
GeneOntologyBiologicalProcesscoronary artery morphogenesis

LRP2 NOTCH1

1.63e-0410402GO:0060982
GeneOntologyBiologicalProcesspositive regulation of axon extension

LRP1 MACF1 LIMK1

1.65e-0455403GO:0045773
GeneOntologyBiologicalProcesssecondary heart field specification

LRP2 ISL1

1.99e-0411402GO:0003139
GeneOntologyBiologicalProcessregulation of secondary heart field cardioblast proliferation

ISL1 NOTCH1

1.99e-0411402GO:0003266
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

LRP1 VWC2L LRP2 KCP FBN1 NOTCH1

2.01e-04445406GO:0141091
GeneOntologyBiologicalProcessventricular cardiac muscle tissue morphogenesis

LRP2 ISL1 NOTCH1

2.04e-0459403GO:0055010
GeneOntologyBiologicalProcessregulation of lysosomal protein catabolic process

LRP1 LRP2

2.39e-0412402GO:1905165
GeneOntologyBiologicalProcesscardiac muscle cell myoblast differentiation

ISL1 NOTCH1

2.39e-0412402GO:0060379
GeneOntologyBiologicalProcesscardioblast proliferation

ISL1 NOTCH1

2.82e-0413402GO:0003263
GeneOntologyBiologicalProcessregulation of cardioblast proliferation

ISL1 NOTCH1

2.82e-0413402GO:0003264
GeneOntologyBiologicalProcesscollecting duct development

NOTCH1 WNT9B

2.82e-0413402GO:0072044
GeneOntologyBiologicalProcessdevelopmental growth

LRP1 ATRN MACF1 LIMK1 EYS MYCBP2 LMX1B NOTCH1

3.07e-04911408GO:0048589
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

LRP1 VWC2L LRP2 KCP FBN1 NOTCH1

3.09e-04482406GO:0007178
GeneOntologyBiologicalProcessregulation of protein catabolic process in the vacuole

LRP1 LRP2

3.29e-0414402GO:1904350
GeneOntologyBiologicalProcesspositive regulation of protein localization to plasma membrane

ZDHHC5 LRP1 ZDHHC8

3.38e-0470403GO:1903078
GeneOntologyBiologicalProcessolfactory behavior

LMX1A LMX1B

3.79e-0415402GO:0042048
GeneOntologyBiologicalProcesscell morphogenesis

LRP1 LRP2 MACF1 LIMK1 ISL1 NIBAN2 MYCBP2 LMX1A NOTCH1

3.79e-041194409GO:0000902
GeneOntologyBiologicalProcesscentral nervous system development

LRP1 LRP2 ATRN ISL1 MYCBP2 LMX1A LMX1B NOTCH1 WNT9B

3.86e-041197409GO:0007417
GeneOntologyBiologicalProcessventricular cardiac muscle tissue development

LRP2 ISL1 NOTCH1

4.31e-0476403GO:0003229
GeneOntologyBiologicalProcessWnt signaling pathway

LRP1 MACF1 ISL1 LMX1A NOTCH1 WNT9B

4.44e-04516406GO:0016055
GeneOntologyBiologicalProcesscardiac muscle tissue morphogenesis

LRP2 ISL1 NOTCH1

4.47e-0477403GO:0055008
GeneOntologyBiologicalProcessanimal organ formation

LRP2 ISL1 NOTCH1

4.65e-0478403GO:0048645
GeneOntologyBiologicalProcessreceptor-mediated endocytosis

LRP1 LRP2 MRC1 LRP1B PDLIM7

4.65e-04337405GO:0006898
GeneOntologyBiologicalProcessgrowth

LRP1 ATRN MACF1 LIMK1 EYS MYCBP2 LMX1A LMX1B NOTCH1

4.86e-041235409GO:0040007
GeneOntologyBiologicalProcessheart field specification

LRP2 ISL1

4.90e-0417402GO:0003128
GeneOntologyBiologicalProcessaorta development

LRP1 LRP2 NOTCH1

5.01e-0480403GO:0035904
GeneOntologyBiologicalProcesspositive regulation of protein localization to cell periphery

ZDHHC5 LRP1 ZDHHC8

5.38e-0482403GO:1904377
GeneOntologyBiologicalProcessmidbrain dopaminergic neuron differentiation

LMX1A WNT9B

5.50e-0418402GO:1904948
GeneOntologyBiologicalProcesscardioblast differentiation

ISL1 NOTCH1

5.50e-0418402GO:0010002
GeneOntologyBiologicalProcesscoronary vasculature development

LRP1 LRP2 NOTCH1

5.58e-0483403GO:0060976
GeneOntologyBiologicalProcessheart development

LRP1 LRP2 PRICKLE4 ISL1 FBN1 PDLIM7 NOTCH1

5.65e-04757407GO:0007507
GeneOntologyBiologicalProcesspositive regulation of neurogenesis

LRP1 LRP2 MACF1 LIMK1 NOTCH1

5.82e-04354405GO:0050769
GeneOntologyBiologicalProcessregulation of growth

LRP1 ATRN MACF1 LIMK1 MYCBP2 LMX1A NOTCH1

6.59e-04777407GO:0040008
GeneOntologyBiologicalProcesscardiac ventricle morphogenesis

LRP2 ISL1 NOTCH1

6.61e-0488403GO:0003208
GeneOntologyBiologicalProcesscardiac septum morphogenesis

LRP2 ISL1 NOTCH1

6.84e-0489403GO:0060411
GeneOntologyBiologicalProcessregulation of Wnt signaling pathway

LRP1 MACF1 ISL1 LMX1A NOTCH1

6.93e-04368405GO:0030111
GeneOntologyBiologicalProcesscardiac chamber development

LRP1 LRP2 ISL1 NOTCH1

7.42e-04212404GO:0003205
GeneOntologyBiologicalProcessregulation of cell proliferation involved in heart morphogenesis

ISL1 NOTCH1

7.52e-0421402GO:2000136
GeneOntologyBiologicalProcesscardiac right ventricle morphogenesis

ISL1 NOTCH1

7.52e-0421402GO:0003215
GeneOntologyBiologicalProcessartery morphogenesis

LRP1 LRP2 NOTCH1

7.53e-0492403GO:0048844
GeneOntologyBiologicalProcessmuscle tissue morphogenesis

LRP2 ISL1 NOTCH1

7.77e-0493403GO:0060415
GeneOntologyBiologicalProcessoutflow tract morphogenesis

LRP2 ISL1 NOTCH1

8.01e-0494403GO:0003151
GeneOntologyBiologicalProcessnegative regulation of neuron differentiation

ISL1 LMX1A NOTCH1

8.01e-0494403GO:0045665
GeneOntologyBiologicalProcesscentral nervous system neuron differentiation

ISL1 MYCBP2 LMX1A LMX1B

8.09e-04217404GO:0021953
GeneOntologyBiologicalProcessmidbrain development

LMX1A LMX1B WNT9B

8.78e-0497403GO:0030901
GeneOntologyBiologicalProcesscell proliferation involved in heart morphogenesis

ISL1 NOTCH1

9.04e-0423402GO:0061323
GeneOntologyBiologicalProcesslysosomal protein catabolic process

LRP1 LRP2

9.85e-0424402GO:1905146
GeneOntologyBiologicalProcessmuscle organ morphogenesis

LRP2 ISL1 NOTCH1

1.02e-03102403GO:0048644
GeneOntologyBiologicalProcessregulation of cell development

LRP1 LRP2 MACF1 LIMK1 NIBAN2 FBN1 NOTCH1 NLRP3

1.04e-031095408GO:0060284
GeneOntologyBiologicalProcessregulation of axon extension

LRP1 MACF1 LIMK1

1.07e-03104403GO:0030516
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

LRP1 VWC2L LRP2 KCP NIBAN2 FBN1 NOTCH1

1.12e-03850407GO:0071363
GeneOntologyBiologicalProcesspositive regulation of developmental growth

LRP1 MACF1 LIMK1 NOTCH1

1.14e-03238404GO:0048639
GeneOntologyBiologicalProcessbrain development

LRP2 ATRN ISL1 LMX1A LMX1B NOTCH1 WNT9B

1.19e-03859407GO:0007420
GeneOntologyBiologicalProcessregulation of nervous system development

LRP1 LRP2 MACF1 LIMK1 NOTCH1 TG

1.21e-03625406GO:0051960
GeneOntologyBiologicalProcesspositive regulation of nervous system development

LRP1 LRP2 MACF1 LIMK1 NOTCH1

1.22e-03418405GO:0051962
GeneOntologyBiologicalProcesspositive regulation of cholesterol efflux

LRP1 ZDHHC8

1.25e-0327402GO:0010875
GeneOntologyBiologicalProcessoutflow tract septum morphogenesis

LRP2 ISL1

1.34e-0328402GO:0003148
GeneOntologyBiologicalProcessprotein catabolic process in the vacuole

LRP1 LRP2

1.34e-0328402GO:0007039
GeneOntologyBiologicalProcesslipoprotein transport

LRP1 LRP2

1.34e-0328402GO:0042953
GeneOntologyBiologicalProcessresponse to growth factor

LRP1 VWC2L LRP2 KCP NIBAN2 FBN1 NOTCH1

1.39e-03883407GO:0070848
GeneOntologyBiologicalProcesspositive regulation of axonogenesis

LRP1 MACF1 LIMK1

1.40e-03114403GO:0050772
GeneOntologyBiologicalProcessembryo development

LRP2 NSD1 MACF1 ISL1 NIBAN2 LRP1B LMX1B NOTCH1 WNT9B

1.44e-031437409GO:0009790
GeneOntologyBiologicalProcessregulation of DNA binding

NSD1 ISL1 NIBAN2

1.44e-03115403GO:0051101
GeneOntologyBiologicalProcesslipoprotein localization

LRP1 LRP2

1.44e-0329402GO:0044872
GeneOntologyBiologicalProcesschemosensory behavior

LMX1A LMX1B

1.65e-0331402GO:0007635
GeneOntologyBiologicalProcessregulation of extent of cell growth

LRP1 MACF1 LIMK1

1.70e-03122403GO:0061387
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

LRP1 VWC2L LRP2 KCP NIBAN2 FBN1 LTK NOTCH1

1.73e-031186408GO:0007167
GeneOntologyBiologicalProcesshead development

LRP2 ATRN ISL1 LMX1A LMX1B NOTCH1 WNT9B

1.75e-03919407GO:0060322
GeneOntologyBiologicalProcessregulation of cellular component biogenesis

ZDHHC5 LRP1 MACF1 LIMK1 ISL1 MYCBP2 ZDHHC8 NOTCH1

1.75e-031189408GO:0044087
GeneOntologyBiologicalProcessprotein palmitoylation

ZDHHC5 ZDHHC8

1.86e-0333402GO:0018345
GeneOntologyCellularComponentaxonal growth cone

LRP1 LRP2 LIMK1

1.08e-0445433GO:0044295
GeneOntologyCellularComponentreceptor complex

LRP1 VWC2L LRP2 LTK LRP1B NOTCH1 APBB1IP

1.67e-04581437GO:0043235
GeneOntologyCellularComponentNSL complex

PHF20 PHF20L1

2.25e-0411432GO:0044545
GeneOntologyCellularComponentextracellular matrix

LRRC3C LAMB4 EYS FBN1 NGLY1 VWF SSPOP

3.50e-04656437GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

LRRC3C LAMB4 EYS FBN1 NGLY1 VWF SSPOP

3.56e-04658437GO:0030312
GeneOntologyCellularComponenthistone methyltransferase complex

NSD1 PHF20 PHF19

4.94e-0475433GO:0035097
GeneOntologyCellularComponentcollagen-containing extracellular matrix

LAMB4 EYS FBN1 NGLY1 VWF SSPOP

7.10e-04530436GO:0062023
GeneOntologyCellularComponentadherens junction

PRICKLE4 NIBAN2 PDLIM7 NOTCH1

9.31e-04212434GO:0005912
GeneOntologyCellularComponentmethyltransferase complex

NSD1 PHF20 PHF19

1.42e-03108433GO:0034708
GeneOntologyCellularComponentfilamentous actin

PRICKLE4 PDLIM7

2.77e-0338432GO:0031941
HumanPhenoUmbilical hernia

LRP2 NSD1 LIMK1 ISL1 FBN1 NOTCH1 TG

4.72e-05306187HP:0001537
HumanPhenoAbnormal umbilicus morphology

LRP2 NSD1 LIMK1 ISL1 FBN1 NOTCH1 TG

5.46e-05313187HP:0001551
HumanPhenoTalipes calcaneovarus

FBN1 LMX1B

7.05e-054182HP:0008124
HumanPhenoAbnormality of external features of the abdomen

LRP2 NSD1 LIMK1 ISL1 FBN1 NOTCH1 TG

7.10e-05326187HP:0001462
HumanPhenoHernia of the abdominal wall

LRP2 NSD1 LIMK1 ISL1 FBN1 NOTCH1 NLRP3 TG

1.59e-04506188HP:0004299
HumanPhenoAbdominal wall defect

LRP2 NSD1 LIMK1 ISL1 FBN1 NOTCH1 NLRP3 TG

1.71e-04511188HP:0010866
HumanPhenoThoracoabdominal wall defect

LRP2 NSD1 LIMK1 ISL1 FBN1 NOTCH1 NLRP3 TG

1.71e-04511188HP:0100656
HumanPhenoLacrimation abnormality

LRP1 LIMK1 NGLY1 NLRP3

2.02e-0487184HP:0000632
HumanPhenoJoint dislocation

LRP1 MACF1 LIMK1 FBN1 NGLY1 LMX1B NLRP3

2.21e-04390187HP:0001373
HumanPhenoIncreased arm span

NSD1 FBN1

2.45e-047182HP:0012771
MousePhenoincreased mean platelet volume

ZDHHC5 FBN1 VWF PHF20L1 PDLIM7 APBB1IP

4.21e-06186336MP:0002599
MousePhenoabnormal platelet volume

ZDHHC5 FBN1 VWF PHF20L1 PDLIM7 APBB1IP

1.60e-05235336MP:0002586
DomainEGF_1

LRP1 LRP2 ATRN LAMB4 EYS FBN1 SSPOP LRP1B NOTCH1

6.69e-09255449PS00022
DomainEGF_2

LRP1 LRP2 ATRN LAMB4 EYS FBN1 SSPOP LRP1B NOTCH1

9.35e-09265449PS01186
DomainLIM

PRICKLE4 LIMK1 ISL1 LMX1A LMX1B PDLIM7

1.29e-0869446PF00412
Domain-

PRICKLE4 LIMK1 ISL1 LMX1A LMX1B PDLIM7

1.41e-08704462.10.110.10
DomainZnf_LIM

PRICKLE4 LIMK1 ISL1 LMX1A LMX1B PDLIM7

1.53e-0871446IPR001781
DomainLIM_DOMAIN_1

PRICKLE4 LIMK1 ISL1 LMX1A LMX1B PDLIM7

1.53e-0871446PS00478
DomainLIM_DOMAIN_2

PRICKLE4 LIMK1 ISL1 LMX1A LMX1B PDLIM7

1.53e-0871446PS50023
DomainLIM

PRICKLE4 LIMK1 ISL1 LMX1A LMX1B PDLIM7

1.53e-0871446SM00132
DomainTIL_dom

LRP2 KCP VWF SSPOP

2.64e-0814444IPR002919
DomainEGF_3

LRP1 LRP2 ATRN EYS FBN1 SSPOP LRP1B NOTCH1

6.69e-08235448PS50026
DomainGrowth_fac_rcpt_

LRP1 LRP2 ATRN EYS FBN1 LRP1B NOTCH1

7.33e-08156447IPR009030
DomainEGF_Ca-bd_CS

LRP1 LRP2 EYS FBN1 LRP1B NOTCH1

1.01e-0797446IPR018097
DomainEGF_CA

LRP1 LRP2 EYS FBN1 LRP1B NOTCH1

1.14e-0799446PS01187
DomainASX_HYDROXYL

LRP1 LRP2 EYS FBN1 LRP1B NOTCH1

1.21e-07100446PS00010
DomainEGF-like_CS

LRP1 LRP2 ATRN LAMB4 EYS FBN1 LRP1B NOTCH1

1.50e-07261448IPR013032
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP1 LRP2 EYS FBN1 LRP1B NOTCH1

1.72e-07106446IPR000152
DomaincEGF

LRP1 LRP2 FBN1 LRP1B

3.86e-0726444IPR026823
DomaincEGF

LRP1 LRP2 FBN1 LRP1B

3.86e-0726444PF12662
DomainEGF_CA

LRP1 LRP2 EYS FBN1 LRP1B NOTCH1

3.96e-07122446SM00179
DomainZinc_finger_PHD-type_CS

NSD1 KDM5D PHF20 PHF20L1 PHF19

4.27e-0765445IPR019786
DomainEGF-like_Ca-bd_dom

LRP1 LRP2 EYS FBN1 LRP1B NOTCH1

4.35e-07124446IPR001881
DomainEGF

LRP1 LRP2 ATRN EYS LRP1B NOTCH1

4.79e-07126446PF00008
DomainEGF

LRP1 LRP2 ATRN EYS FBN1 LRP1B NOTCH1

1.18e-06235447SM00181
DomainVWFC_1

VWC2L KCP VWF SSPOP

1.49e-0636444PS01208
DomainEGF-like_dom

LRP1 LRP2 ATRN EYS FBN1 LRP1B NOTCH1

1.73e-06249447IPR000742
DomainEGF_CA

LRP1 LRP2 FBN1 LRP1B NOTCH1

1.74e-0686445PF07645
DomainVWC

VWC2L KCP VWF SSPOP

1.87e-0638444SM00214
DomainVWFC_2

VWC2L KCP VWF SSPOP

1.87e-0638444PS50184
DomainLDLR_class-A_CS

LRP1 LRP2 SSPOP LRP1B

2.30e-0640444IPR023415
DomainVWF_dom

VWC2L KCP VWF SSPOP

2.81e-0642444IPR001007
DomainZF_PHD_1

NSD1 KDM5D PHF20 PHF20L1 PHF19

2.99e-0696445PS01359
DomainUnchr_dom_Cys-rich

KCP VWF SSPOP

3.43e-0613443IPR014853
DomainC8

KCP VWF SSPOP

3.43e-0613443SM00832
DomainLdl_recept_a

LRP1 LRP2 SSPOP LRP1B

3.72e-0645444PF00057
Domain-

LRP1 LRP2 SSPOP LRP1B

4.07e-06464444.10.400.10
DomainLdl_recept_b

LRP1 LRP2 LRP1B

4.36e-0614443PF00058
DomainLDLRB

LRP1 LRP2 LRP1B

4.36e-0614443PS51120
DomainLDLRA_1

LRP1 LRP2 SSPOP LRP1B

4.83e-0648444PS01209
DomainLDLRA_2

LRP1 LRP2 SSPOP LRP1B

5.25e-0649444PS50068
DomainLDrepeatLR_classA_rpt

LRP1 LRP2 SSPOP LRP1B

5.25e-0649444IPR002172
DomainLDLa

LRP1 LRP2 SSPOP LRP1B

5.25e-0649444SM00192
DomainDUF3776

PHF20 PHF20L1

5.42e-062442PF12618
DomainDUF3776

PHF20 PHF20L1

5.42e-062442IPR022255
DomainDUF5050

LRP1 LRP1B

5.42e-062442IPR032485
DomainDUF5050

LRP1 LRP1B

5.42e-062442PF16472
DomainLY

LRP1 LRP2 LRP1B

5.44e-0615443SM00135
DomainLDLR_classB_rpt

LRP1 LRP2 LRP1B

5.44e-0615443IPR000033
DomainVWD

KCP VWF SSPOP

6.69e-0616443SM00216
DomainVWF_type-D

KCP VWF SSPOP

6.69e-0616443IPR001846
DomainVWFD

KCP VWF SSPOP

6.69e-0616443PS51233
DomainVWD

KCP VWF SSPOP

6.69e-0616443PF00094
DomainVWC_out

KCP VWF SSPOP

1.15e-0519443SM00215
DomainEGF_extracell

LRP2 ATRN LRP1B NOTCH1

1.19e-0560444IPR013111
DomainEGF_2

LRP2 ATRN LRP1B NOTCH1

1.19e-0560444PF07974
DomainZnf_FYVE_PHD

NSD1 KDM5D PHF20 PHF20L1 PHF19

2.39e-05147445IPR011011
DomainPHD

NSD1 KDM5D PHF20 PHF19

2.88e-0575444PF00628
DomainTUDOR

PHF20 PHF20L1 PHF19

3.43e-0527443SM00333
DomainZnf_PHD-finger

NSD1 KDM5D PHF20 PHF19

3.54e-0579444IPR019787
DomainTudor

PHF20 PHF20L1 PHF19

4.74e-0530443IPR002999
DomainPHD

NSD1 KDM5D PHF20 PHF19

5.65e-0589444SM00249
DomainZnf_PHD

NSD1 KDM5D PHF20 PHF19

6.17e-0591444IPR001965
DomainZF_PHD_2

NSD1 KDM5D PHF20 PHF19

7.30e-0595444PS50016
Domain-

NSD1 KDM5D PHF20 PHF20L1 PHF19 MYCBP2 OBI1

7.86e-054494473.30.40.10
DomainZnf_RING/FYVE/PHD

NSD1 KDM5D PHF20 PHF20L1 PHF19 MYCBP2 OBI1

9.02e-05459447IPR013083
Domain-

LRP1 LRP2 LRP1B

1.05e-04394432.120.10.30
Domain6-blade_b-propeller_TolB-like

LRP1 LRP2 LRP1B

1.73e-0446443IPR011042
DomainTIL

VWF SSPOP

3.53e-0412442PF01826
DomainC8

VWF SSPOP

3.53e-0412442PF08742
DomainCTCK_1

VWF SSPOP

8.10e-0418442PS01185
Domainzf-DHHC

ZDHHC5 ZDHHC8

1.33e-0323442PF01529
DomainGalactose-bd-like

NGLY1 MYCBP2 SSPOP

1.41e-0394443IPR008979
DomainCys_knot_C

VWF SSPOP

1.57e-0325442IPR006207
DomainDHHC

ZDHHC5 ZDHHC8

1.57e-0325442PS50216
DomainCTCK_2

VWF SSPOP

1.57e-0325442PS01225
DomainZnf_DHHC_palmitoyltrfase

ZDHHC5 ZDHHC8

1.57e-0325442IPR001594
DomainhEGF

EYS NOTCH1

1.97e-0328442PF12661
DomainVWC

KCP VWF

1.97e-0328442PF00093
DomainEGF_LAM_2

ATRN LAMB4

2.26e-0330442PS50027
DomainEGF_LAM_1

ATRN LAMB4

2.26e-0330442PS01248
Pubmed

Diverse expression patterns of LIM-homeodomain transcription factors (LIM-HDs) in mammalian inner ear development.

ISL1 LMX1A LMX1B

6.59e-08744318942141
Pubmed

Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.

LRP1 ISL1 LMX1A LMX1B

6.84e-083144419796621
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1 LRP2 LRP1B

3.10e-071144324639464
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

LRP1 LRP2 LRP1B

6.81e-071444315082773
Pubmed

Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner.

ISL1 LMX1A LMX1B

1.05e-061644317596284
Pubmed

Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools.

ISL1 LMX1A LMX1B

1.05e-061644319850875
Pubmed

Otx2 Requires Lmx1b to Control the Development of Mesodiencephalic Dopaminergic Neurons.

ISL1 LMX1A LMX1B

1.05e-061644326444681
Pubmed

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development.

ISL1 LMX1A LMX1B

1.27e-061744319607821
Pubmed

Detailed expression analysis of regulatory genes in the early developing human neural tube.

ISL1 LMX1A LMX1B

1.27e-061744324007338
Pubmed

Notch signaling is a critical initiator of roof plate formation as revealed by the use of RNA profiling of the dorsal neural tube.

ISL1 LMX1A NOTCH1

1.52e-061844333892704
Pubmed

Striking differences of LDL receptor-related protein 1B expression in mouse and human.

LRP1 LRP1B

1.56e-06244215963947
Pubmed

Identification of a human LMX1 (LMX1.1)-related gene, LMX1.2: tissue-specific expression and linkage mapping on chromosome 9.

LMX1A LMX1B

1.56e-0624429441763
Pubmed

Do polymorphisms in transcription factors LMX1A and LMX1B influence the risk for Parkinson's disease?

LMX1A LMX1B

1.56e-06244219189040
Pubmed

Exome sequencing identified new mutations in a Marfan syndrome family.

LRP1 FBN1

1.56e-06244224484584
Pubmed

Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly.

ZDHHC5 ZDHHC8

1.56e-06244225049274
Pubmed

Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.

LRP1 LRP2

1.56e-06244234445520
Pubmed

The dendritic cell mannose receptor mediates allergen internalization and maturation involving notch 1 signalling.

MRC1 NOTCH1

1.56e-06244220819091
Pubmed

Megalin (gp330): a putative endocytic receptor for thyroglobulin (Tg).

LRP2 TG

1.56e-0624429492085
Pubmed

Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages.

LMX1A LMX1B

1.56e-06244228094018
Pubmed

Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.

LMX1A LMX1B

1.56e-06244226526610
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

LRP1 LRP2 FBN1 SSPOP

2.03e-067144433541421
Pubmed

Shh dependent and independent maintenance of basal midbrain.

ISL1 LMX1A LMX1B

2.12e-062044319298856
Pubmed

Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.

ISL1 LMX1A LMX1B

2.12e-062044323637192
Pubmed

An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool.

ISL1 LMX1A LMX1B

2.12e-062044324348261
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP1 LRP2 LRP1B

2.47e-062144321337463
Pubmed

Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors.

ISL1 LMX1A LMX1B

3.29e-062344326164566
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

LRP1 LRP2 ATRN MACF1 TNFRSF25 LIMK1 FBN1 VWF MYCBP2 LRP1B

3.61e-061285441035914814
Pubmed

LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth.

ISL1 LMX1A LMX1B

4.26e-062544319304889
Pubmed

Neutrophil NLRP3 promotes cardiac injury following acute myocardial infarction through IL-1β production, VWF release and NET deposition in the myocardium.

VWF NLRP3

4.69e-06344238914598
Pubmed

Recombinant von Willebrand factor-insight into structure and function through infusion studies in animals with severe von Willebrand disease.

LRP1 VWF

4.69e-06344211992244
Pubmed

Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking.

ZDHHC5 ZDHHC8

4.69e-06344222325201
Pubmed

Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.

ZDHHC5 ZDHHC8

4.69e-06344219801377
Pubmed

Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity.

LMX1A LMX1B

4.69e-0634429199284
Pubmed

Shear stress-independent binding of von Willebrand factor-type 2B mutants p.R1306Q & p.V1316M to LRP1 explains their increased clearance.

LRP1 VWF

4.69e-06344225728415
Pubmed

Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia.

LMX1A LMX1B

4.69e-06344220570600
Pubmed

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development.

ISL1 LMX1A LMX1B

4.81e-062644321752929
Pubmed

Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.

VWC2L ISL1 NOTCH1

5.41e-062744324496616
Pubmed

Distinct populations of GABAergic neurons in mouse rhombomere 1 express but do not require the homeodomain transcription factor PITX2.

ISL1 LMX1A LMX1B

5.41e-062744321925604
Pubmed

Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons.

ISL1 LMX1A LMX1B

6.75e-062944329874580
Pubmed

Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.

ISL1 LMX1A LMX1B

7.49e-063044321880902
Pubmed

Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening.

LRP1 ISL1 NOTCH1

8.28e-063144332546759
Pubmed

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain.

ISL1 LMX1A LMX1B

8.28e-063144319592574
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

LRP1 LRP2 LRP1B NOTCH1

8.32e-0610144423382219
Pubmed

ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.

ZDHHC5 NLRP3

9.37e-06444238092000
Pubmed

Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.

LRP1 LRP2

9.37e-06444212413896
Pubmed

Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation.

LMX1A WNT9B

9.37e-06444225640183
Pubmed

Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.

LRP1 LRP2

9.37e-0644427775583
Pubmed

Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E.

LRP1 LRP2

9.37e-06444211421580
Pubmed

The transcriptional control of trunk neural crest induction, survival, and delamination.

ISL1 LMX1A NOTCH1

1.10e-053444315691760
Pubmed

Cell-autonomous FGF signaling regulates anteroposterior patterning and neuronal differentiation in the mesodiencephalic dopaminergic progenitor domain.

ISL1 LMX1A LMX1B

1.31e-053644322278924
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

LRP1 FBN1 VWF NOTCH1

1.54e-0511844421078624
Pubmed

BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells.

ISL1 LMX1A LMX1B

1.55e-053844329321139
Pubmed

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

LRP1 LRP2

1.56e-05544219047013
Pubmed

Cutting Edge: The Heat Shock Protein gp96 Activates Inflammasome-Signaling Platforms in APCs.

LRP1 NLRP3

1.56e-05544230209191
Pubmed

Notch post-translationally regulates β-catenin protein in stem and progenitor cells.

ISL1 NOTCH1

1.56e-05544221841793
Pubmed

Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.

LRP1 LRP2

1.56e-05544218685438
Pubmed

ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association.

LRP1 LRP2

1.56e-05544216101684
Pubmed

Control of roof plate formation by Lmx1a in the developing spinal cord.

ISL1 LMX1A

1.56e-05544215148302
Pubmed

Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways.

ISL1 LMX1B

1.56e-05544214627719
Pubmed

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.

LRP1 LRP2

2.34e-0564429837937
Pubmed

Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells.

NOTCH1 WNT9B

2.34e-05644221852398
Pubmed

Role for p21-activated kinase PAK4 in development of the mammalian heart.

LIMK1 ISL1

2.34e-05644222173944
Pubmed

Expression of Deltex1 during mouse embryogenesis: comparison with Notch1, 2 and 3 expression.

ISL1 NOTCH1

2.34e-05644211731257
Pubmed

Opposite Control of Excitatory and Inhibitory Synapse Formation by Slitrk2 and Slitrk5 on Dopamine Neurons Modulates Hyperactivity Behavior.

LMX1A LMX1B

2.34e-05644232075770
Pubmed

Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.

ISL1 LMX1A LMX1B

2.58e-054544323193182
Pubmed

Notch1 haploinsufficiency causes ascending aortic aneurysms in mice.

FBN1 NOTCH1

3.27e-05744229093270
Pubmed

Tissue specific characterisation of Lim-kinase 1 expression during mouse embryogenesis.

LIMK1 ISL1

3.27e-05744221167960
Pubmed

A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate.

ISL1 NOTCH1

3.27e-05744219620969
Pubmed

The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors.

ISL1 LMX1A

3.27e-0574429452425
Pubmed

The Cofilin/Limk1 Pathway Controls the Growth Rate of Both Developing and Regenerating Motor Axons.

LIMK1 ISL1

3.27e-05744231578231
Pubmed

The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.

LRP1 LRP2

3.27e-05744212169628
Pubmed

Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse.

LMX1A LMX1B

4.36e-05844226424886
Pubmed

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses.

MRC1 NLRP3

4.36e-05844221059925
Pubmed

Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation.

LMX1A LMX1B

4.36e-05844229038581
Pubmed

Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade.

NOTCH1 NLRP3

4.36e-05844225825216
Pubmed

Protein-protein interaction of zinc finger LIM domains with protein kinase C.

LIMK1 PDLIM7

4.36e-0584428940095
Pubmed

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development.

VWF NOTCH1

4.36e-05844218245384
Pubmed

Molecular Fingerprint and Developmental Regulation of the Tegmental GABAergic and Glutamatergic Neurons Derived from the Anterior Hindbrain.

LMX1A LMX1B NOTCH1

5.00e-055644333053343
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

FBN1 VWF

5.60e-05944212122015
Pubmed

Lmx1a and Lmx1b are Redundantly Required for the Development of Multiple Components of the Mammalian Auditory System.

LMX1A LMX1B

5.60e-05944233246067
Pubmed

Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction.

PDLIM7 NOTCH1

5.60e-05944224278323
Pubmed

Overlapping function of Lmx1a and Lmx1b in anterior hindbrain roof plate formation and cerebellar growth.

LMX1A LMX1B

5.60e-05944219741143
Pubmed

Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway.

LMX1A LMX1B

5.60e-05944219951692
Pubmed

Generation of a Nkx2.2(Cre) knock-in mouse line: Analysis of cell lineages in the central nervous system.

ISL1 LMX1B

5.60e-05944225840610
Pubmed

LDL receptor-related protein as a component of the midkine receptor.

LRP1 LRP2

5.60e-05944210772929
Pubmed

Ectopic expression of Gcm1 induces congenital spinal cord abnormalities.

ISL1 NOTCH1

5.60e-05944212135932
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZDHHC5 LIMK1 KDM5D PHF20 PHF20L1 PHF19 LMX1A

6.45e-0580844720412781
Pubmed

Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons.

ISL1 LMX1B

6.99e-051044215901662
Pubmed

Functional and comparative genomic analysis of the piebald deletion region of mouse chromosome 14.

MYCBP2 OBI1

6.99e-051044212160731
Pubmed

The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis.

ISL1 NOTCH1

6.99e-051044234571841
Pubmed

Locomotor rhythm generation linked to the output of spinal shox2 excitatory interneurons.

ISL1 LMX1B

6.99e-051044224267650
Pubmed

Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons.

ISL1 LMX1B

6.99e-051044229719245
Pubmed

SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System.

ISL1 NOTCH1

6.99e-051044228215559
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

FBN1 NGLY1 VWF SSPOP

7.19e-0517544428071719
Pubmed

The developmental and genetic basis of 'clubfoot' in the peroneal muscular atrophy mutant mouse.

LIMK1 ISL1

8.54e-051144229439133
Pubmed

Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity.

VWF NOTCH1

8.54e-051144215875024
Pubmed

Notch1 control of oligodendrocyte differentiation in the spinal cord.

ISL1 NOTCH1

8.54e-051144212186854
Pubmed

A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development.

ISL1 NOTCH1

8.54e-051144227224017
Pubmed

A forward genetic screen in mice identifies mutants with abnormal cortical patterning.

LRP2 MYCBP2

8.54e-051144223968836
Pubmed

Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis.

ISL1 LMX1A

8.54e-051144221347250
InteractionNTN5 interactions

LRP2 FBN1 LRP1B NOTCH1

1.85e-0724434int:NTN5
InteractionIGFL3 interactions

LRP2 ATRN MYCBP2 LRP1B NOTCH1

5.37e-0775435int:IGFL3
InteractionZFP41 interactions

LRP1 LRP2 FBN1 LRP1B

6.54e-0657434int:ZFP41
InteractionLCOR interactions

LRP1 MACF1 VWF PHF19 MYCBP2 LRP1B

1.18e-05242436int:LCOR
InteractionFBXO2 interactions

LRP2 ATRN FBN1 H6PD ERVMER34-1 LRP1B NOTCH1

2.38e-05411437int:FBXO2
InteractionNDP interactions

ATRN MYCBP2 LRP1B

5.65e-0535433int:NDP
InteractionHOXA1 interactions

VWC2L PRICKLE4 FBN1 VWF LMX1B NOTCH1

1.02e-04356436int:HOXA1
InteractionDNER interactions

PDLIM7 NOTCH1

1.24e-048432int:DNER
InteractionZDHHC15 interactions

LRP1 LRP2 FBN1 SSPOP

1.44e-04125434int:ZDHHC15
InteractionDYRK1A interactions

LRP2 ATRN TNFRSF25 FBN1 MYCBP2 LRP1B PDLIM7

1.52e-04552437int:DYRK1A
InteractionDKK2 interactions

LRP2 LRP1B NOTCH1

1.56e-0449433int:DKK2
InteractionLMX1A interactions

ISL1 LMX1A

1.98e-0410432int:LMX1A
InteractionSERPINE1 interactions

LRP1 LRP2 LRP1B

2.08e-0454433int:SERPINE1
InteractionLDB2 interactions

ISL1 LMX1A LMX1B

2.32e-0456433int:LDB2
InteractionALKAL2 interactions

LRP2 LTK

2.42e-0411432int:ALKAL2
InteractionZNF408 interactions

LRP2 ATRN FBN1 LRP1B

2.55e-04145434int:ZNF408
InteractionANKRD36B interactions

LRP1 LRP2 LRP1B

2.84e-0460433int:ANKRD36B
InteractionTG interactions

LRP2 TG

3.98e-0414432int:TG
InteractionANAPC10 interactions

LRP1 LRP2 NLRP3

4.12e-0468433int:ANAPC10
Cytoband12p13.3

VWF CD163L1

3.84e-043044212p13.3
GeneFamilyPHD finger proteins

NSD1 KDM5D PHF20 PHF20L1 PHF19

2.95e-079029588
GeneFamilyLIM class homeoboxes

ISL1 LMX1A LMX1B

8.08e-0712293522
GeneFamilyLow density lipoprotein receptors

LRP1 LRP2 LRP1B

1.05e-0613293634
GeneFamilyTudor domain containing

PHF20 PHF20L1 PHF19

2.78e-0537293780
GeneFamilyLIM domain containing

PRICKLE4 LIMK1 PDLIM7

1.14e-04592931218
GeneFamilyZinc fingers DHHC-type|Ankyrin repeat domain containing

ZDHHC5 ZDHHC8

6.71e-042429276
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

MRC1 CD163L1

8.51e-04272921253
CoexpressionNABA_ECM_GLYCOPROTEINS

KCP LAMB4 EYS FBN1 VWF SSPOP

9.02e-07196446M3008
CoexpressionNABA_CORE_MATRISOME

KCP LAMB4 EYS FBN1 VWF SSPOP

6.38e-06275446M5884
CoexpressionGSE20715_WT_VS_TLR4_KO_24H_OZONE_LUNG_DN

NIBAN2 FBN1 VWF KDM5D PDLIM7

2.10e-05200445M4354
CoexpressionNABA_MATRISOME

VWC2L KCP LAMB4 EYS FBN1 NGLY1 VWF SSPOP WNT9B

4.29e-051026449M5889
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MRC1 CD163L1 NLRP3 APBB1IP

1.21e-06190445788ff9d8888d2dd25b7e1d7e0e5d57751ce86f19
ToppCellLA|World / Chamber and Cluster_Paper

LRP1 LRP2 FBN1 LRP1B PDLIM7

1.31e-06193445d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MRC1 CD163L1 NLRP3 APBB1IP

1.38e-0619544534a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCellTracheal-10x5prime-Endothelial-Endothelia_lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 LRRC70 SSPOP CD163L1 WNT9B

1.48e-0619844505429f18e1d74880c1835568c86177f661b3477a
ToppCellTracheal-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 LRRC70 SSPOP CD163L1 WNT9B

1.48e-06198445306e28d31fd587409a12dcccc6b2abd7dc9c2e0a
ToppCelldroplet-Skin-nan-18m|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ISL1 KDM5D LMX1A CD163L1

7.07e-061254445a309ce803d2b8efd791eb21808121bf5fc3ea8e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 CD163L1 NLRP3 APBB1IP

2.27e-0516844461a5435b27b01ff1a509ea463a6af220c5d2c9b3
ToppCelldroplet-Fat-Bat-18m-Myeloid-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRN KDM5D DMAC2 TG

2.27e-051684446fddc957a0503455d8c165862b5eb8e5fdb8a510
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 CD163L1 NLRP3 APBB1IP

2.27e-0516844426fce414439ccd204e3acb41f2b4f75072df5a26
ToppCelldroplet-Fat-Bat-18m-Myeloid-myeloid_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRN KDM5D DMAC2 TG

2.27e-05168444794035cb63353a7d02fd9939deb5b4d075c9d95a
ToppCelldroplet-Fat-Bat-18m-Myeloid|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRN KDM5D DMAC2 TG

2.27e-051684441e23b634f96e88b976a523ca1f3fc08f6fe9b239
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MACF1 FBN1 VWF H6PD

2.37e-051704447fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCellCOVID-19-Heart-CM_+_Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

MRC1 CD163L1 APBB1IP TG

2.37e-051704444232fe937909f93d3736988c707b8f95ce993398
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 ATRN MRC1 APBB1IP

2.54e-0517344420f7dfe7d92a3dbec9da9a1f3185aa10cb8f0a3c
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Dedifferentiated_Liposarcoma|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

LRP1 MRC1 FBN1 CD163L1

2.66e-051754442eca4c168dea2017ea0e383006e28abed22f32ec
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3|TCGA-Cervix / Sample_Type by Project: Shred V9

ZDHHC5 LRP1 PRICKLE4 MYCBP2

2.66e-051754440cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

LRP1 FBN1 LMX1A LRP1B

2.72e-051764442e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

LRP1 FBN1 LMX1A LRP1B

2.72e-05176444f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCellLPS_only-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 MRC1 NLRP3 APBB1IP

2.90e-05179444dc03b9045510eb1bb934329646bb92dd06890ce9
ToppCellLPS_only-Myeloid-Monocytes,_Macrophages|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 MRC1 NLRP3 APBB1IP

2.90e-05179444330c1326ba93bb8f32559ee1cc40e357cc44ad8d
ToppCellP28-Mesenchymal-mesenchymal_fibroblast|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP1 MACF1 FBN1 H6PD

3.03e-05181444091e7975badd1ffa463a8ec87908be20781ecfd6
ToppCellP28-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP1 MACF1 FBN1 H6PD

3.10e-0518244419c5e3a9d9b3728303b682102e276adfe93aa759
ToppCellP28-Mesenchymal|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP1 MACF1 FBN1 H6PD

3.10e-0518244469f9d44694fe4f55a971ae0ac5dc3e7448ee78f3
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c5-WDR74|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP1 MRC1 NIBAN2 NLRP3

3.30e-0518544468edb1bb03ed221d49e583123ca4de14252d7bc5
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MRC1 TNFRSF25 CD163L1 NLRP3

3.44e-0518744439b99f46b723f7f3c44880d7fe8642cbad558b8a
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_migrating_dendritic_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

3.52e-051884448fc15c8b78fdd1a578e34325011bc5a87a8aab31
ToppCellE16.5-samps-Mesenchymal|E16.5-samps / Age Group, Lineage, Cell class and subclass

LRP1 MACF1 FBN1 H6PD

3.52e-051884443f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 FBN1 LRRC70 VWF

3.52e-0518844426915db8863f4115b46a81982e187322e21600fd
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 FBN1 LRRC70 VWF

3.52e-051884443f76c0f912f8f023ea425be7f43593b3d7f967e3
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 FBN1 LRRC70 VWF

3.52e-0518844461ee7b152745164293d8a44ef91ee2393efbdca5
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 MACF1 FBN1 H6PD

3.59e-05189444324c81285c51f4f8bb1aef428b18fe2c549c2c11
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte2_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

3.67e-05190444e5625feb21915d4545cfad2659745ef180efcb1f
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

3.67e-05190444081b7bc07b6e5685e8a91b9ae6c1141623723700
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP1 MACF1 FBN1 H6PD

3.74e-0519144444a9a6768084dafc641ad455b65862bfd4cc0cb9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MRC1 CD163L1 APBB1IP

3.74e-0519144451f5af610983aa73b9f4ece6f27d281ebff89a04
ToppCellControl-Myeloid|Control / group, cell type (main and fine annotations)

LRP1 MRC1 CD163L1 TG

3.74e-051914449c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 CD163L1 NLRP3 APBB1IP

3.74e-05191444baa70781633a3fe5bf987f9d8dff3884f5167e7f
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal|E16.5-samps / Age Group, Lineage, Cell class and subclass

LRP1 MACF1 FBN1 H6PD

3.74e-051914443379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP1 MACF1 FBN1 H6PD

3.74e-05191444094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

LRP1 MACF1 FBN1 H6PD

3.74e-05191444e7c605b56934d1383237c1f946dbccef25d91368
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

3.74e-0519144409dfad8e1fcaaf94775134796b99e4e3fbb9bf40
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP1 MACF1 FBN1 H6PD

3.74e-0519144480484d39f34703a33b9bac09826b7a526e883cab
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MRC1 CD163L1 APBB1IP

3.74e-051914448fd6bdc9d2b1c8d364221d7bc68d03921b668ab5
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP1 MACF1 FBN1 H6PD

3.74e-051914445c4e4e9de14edfae072a2a2882220a31bebf51b2
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 CD163L1 NLRP3 APBB1IP

3.82e-0519244486d792682ba51696f503c79625dd20f87bcf651f
ToppCellPND14-Mesenchymal-Mesenchymal_structural|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

3.82e-0519244425492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 CD163L1 NLRP3 APBB1IP

3.82e-05192444d0ad6a205ad50a3c523fa68676996b289eabc5de
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_proliferating_myeloid_(8)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

3.82e-051924447e7383093efaadceadd4d1f900c2d39cd690102e
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

3.82e-05192444de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage1_(2)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

3.82e-051924444e3deefd30adb7bf1eba294610eed3d077aa9418
ToppCellPCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_neutrophils_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

3.90e-05193444c9e3fefa8d68d0e2b954f85ce37813185ff98d84
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

3.90e-051934444c74a3f69b2cbdf139e7e66b44bd86869ac34dc0
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

3.90e-05193444ff8ceeb3cfd1bef7239df490c19d181091750833
ToppCellwk_08-11-Hematologic-Myeloid-CX3CR1+_Mac|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

3.90e-05193444afc20433b5abc9b430751a2aa8d93b0fd136a888
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP1 NIBAN2 PDLIM7 NLRP3

3.90e-05193444d845beb0915a5b4bbd1e8f9b8d9322527a822849
ToppCellRA-08._Macrophage|World / Chamber and Cluster_Paper

MRC1 NLRP3 APBB1IP TG

3.90e-051934445fd22db1825d105709fcc0aa4955c99a117e3c82
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 CD163L1 NLRP3 APBB1IP

3.90e-05193444f597fefc54327a1ad136e2f66b6e81cc5c761eb7
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_macrophage|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

3.98e-05194444ef30baa19b7aa97b61dea916fc2e0f5cf49848d6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 CD163L1 NLRP3 APBB1IP

3.98e-051944440866ab6792cee274a71991d5c37a37f574ff446e
ToppCellkidney_cells-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MRC1 CD163L1 NLRP3

3.98e-05194444abce1e824ce2512741c313a5ec336d12f580b093
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MRC1 CD163L1 NLRP3

3.98e-051944441dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCellkidney_cells-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MRC1 CD163L1 NLRP3

3.98e-051944446810586080cc893e3270b9c8bee2d95ed78e2893
ToppCellPCW_07-8.5-Hematologic_Myeloid|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

3.98e-05194444260649f5c4aeaa9cbf5ed5ae5e9f293d75bb0457
ToppCellPND01-Mesenchymal-Mesenchymal_structural|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

4.06e-051954446bb6349d6ec8da094fe1c7c590021989337aeb0b
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

4.06e-051954443a0cad69cfc150a27a0666f612f5294c817197d7
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|lung / Disease (COVID-19 only), tissue and cell type

LRP1 MRC1 CD163L1 APBB1IP

4.06e-05195444148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

4.06e-05195444e8fb552f9ab77b656c27abc66af523b56cd9f9ad
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

4.06e-051954442b8ee7990267bb52b7e6ae03f509ffebf8908122
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

4.06e-051954446c354c38ee2965d37152ffdc86ba929ba2049c6a
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

MRC1 CD163L1 NLRP3 APBB1IP

4.06e-05195444ba7f85e5307d96ac5ad7c952f8d094db9ca1790c
ToppCellmyeloid-Monocyte-CD14+_Monocyte|myeloid / Lineage, cell class and subclass

LRP1 NIBAN2 PDLIM7 NOTCH1

4.06e-0519544415ba9c5f6ecb6ae2c603e6b036eb92b00b46f13f
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

4.06e-05195444518cc3baeb7cf2ad068692cbe85fd75be67f1872
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NSD1 MACF1 KDM5D MYCBP2

4.06e-051954443e519cffa6144a62b06124642a14c9ff39b76554
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 CD163L1 NLRP3 APBB1IP

4.06e-051954447b6c69df943842b566a596e30bb50dbe80dccc83
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MRC1 NLRP3 APBB1IP

4.06e-0519544409df40ff9b493170861b3f6e57a942a834655b5c
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

4.06e-05195444a3b468125e48f072255cede7645f6692298ecf54
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 CD163L1 NLRP3 APBB1IP

4.14e-051964444370473693d2dd4a8c451a4c477eb79baa33ae12
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast|PND01-03-samps / Age Group, Lineage, Cell class and subclass

LRP1 MACF1 FBN1 H6PD

4.14e-0519644454f4cf778f95a9ff662e5c7520916a25e605bf95
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_proliferating_myeloid_(8)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MRC1 CD163L1 NLRP3 APBB1IP

4.14e-051964443fd5567ea14193181929134c377e8a38fb4f47fd
ToppCellE18.5-Mesenchymal-Mesenchymal_structural|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

4.14e-0519644497e26622d9582b092c18ff5b7e957818f99d9631
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

4.14e-05196444617103f4a09e009fe96c28eb5e40505a4fd6dcf4
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

4.14e-05196444f429f045ba45e24717963315832150b12a115bfa
ToppCellCOVID-19-lung-Macrophage_metabolically_active|lung / Disease (COVID-19 only), tissue and cell type

LRP1 MRC1 CD163L1 APBB1IP

4.14e-05196444a753d76d764c181eecb0e17a794a2e7d0ff70136
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

4.14e-05196444db64ab27374f82553ee577aec056141170f3656f
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

4.22e-0519744406a0d7062dadda656decaf77dcef9a10b5f2698d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 CD163L1 NLRP3 APBB1IP

4.22e-051974446ca6e17b7cc5f7ea8d4b6ca1ff670969bee65a45
ToppCellPND01-Mesenchymal|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

4.22e-05197444292b8cc3dafddf5d323fe4e3d3ea5ac61e6ce027
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 CD163L1 NLRP3 APBB1IP

4.22e-05197444d95565652ca318a2298d6918d54ba6367e9560f4
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 MACF1 FBN1 H6PD

4.22e-05197444d35c7a36135b5ed6a7bf2f934849678eba2a0177
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 CD163L1 NLRP3 APBB1IP

4.30e-0519844496883ad8e189a46ed5b7eaafc0543e53682d26ed
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LRP1 MRC1 NIBAN2 NLRP3

4.30e-05198444c1fe38594bd6292fcc60bdbb563376b454731d00
ToppCellControl_saline-Hematopoietic_Myeloid-Monocytes,_Macrophages|Control_saline / Treatment groups by lineage, cell group, cell type

MRC1 CD163L1 NLRP3 APBB1IP

4.30e-05198444684f2dd5db889f118b5218ee23733cc1361272c2
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP1 MRC1 NIBAN2 NLRP3

4.30e-0519844494e2567f057b2c455a9656b121321a28e7cb1d2b
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP1 MRC1 NIBAN2 NLRP3

4.30e-05198444f3a12a7e23bb4ff6e82fee675dbc090d99587f69
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LRP1 MRC1 CD163L1 NLRP3

4.30e-05198444c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCellControl_saline-Hematopoietic_Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|Control_saline / Treatment groups by lineage, cell group, cell type

MRC1 CD163L1 NLRP3 APBB1IP

4.30e-05198444c15ab0660a6de445a83396cf70860ea39868914d
ToppCellCaecum-(6)_Macrophage-(61)_LYVE1_Macrophage|Caecum / shred on region, Cell_type, and subtype

LRP1 MRC1 NIBAN2 SSPOP

4.30e-05198444e684c3934c163aef4d284b69435832d2c9614f2a
ToppCellCOVID-19-kidney-Macrophages|kidney / Disease (COVID-19 only), tissue and cell type

LRP1 MRC1 NLRP3 APBB1IP

4.30e-05198444161324541fe5da5cbb58142ea94fefd39b7dfb04
ToppCellCaecum-Macrophage-LYVE1_Macrophage|Caecum / Region, Cell class and subclass

LRP1 MRC1 NIBAN2 SSPOP

4.30e-05198444a92c0cacb775aca6bbb302bd9e22c081a112a44d
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LRP1 MRC1 NIBAN2 NLRP3

4.30e-05198444bfc15de70a7577a2860b53e1e6826a7b5ad23040
Drugvitamin E

LRP1 LRP2 TNFRSF25 EYS VWF H6PD LRP1B

2.01e-05441447CID000002116
Drugmonatepil

LRP1 LRP2 LRP1B

2.38e-0529443CID000060810
Drug(2s,5s)-5-Carboxymethylproline

NSD1 MRC1 TNFRSF25 FBN1 VWF TG

2.98e-05314446CID000447989
DrugTestosterone propionate [57-85-2]; Up 200; 11.6uM; PC3; HT_HG-U133A

LRP2 LAMB4 TNFRSF25 PHF20 PDLIM7

3.45e-051934454676_UP
DrugFlucytosine [2022-85-7]; Down 200; 31uM; MCF7; HT_HG-U133A

NSD1 ATRN MACF1 PDLIM7 NOTCH1

3.45e-051934455289_DN
Drugp-m-p-m-p

NGLY1 TG

3.64e-055442CID000124732
DrugMethiazole; Down 200; 15uM; PC3; HT_HG-U133A

TNFRSF25 FBN1 PHF20 PDLIM7 NOTCH1

3.71e-051964453796_DN
DrugMethoxamine hydrochloride [61-16-5]; Down 200; 16.2uM; PC3; HT_HG-U133A

TNFRSF25 LIMK1 H6PD PDLIM7 NOTCH1

3.71e-051964456627_DN
DrugMetrizamide [31112-62-6]; Down 200; 5uM; PC3; HT_HG-U133A

LRP1 TNFRSF25 LIMK1 PHF20 NOTCH1

4.09e-052004454075_DN
Diseasemesangial proliferative glomerulonephritis (biomarker_via_orthology)

FBN1 VWF

5.51e-058422DOID:4783 (biomarker_via_orthology)
Diseaseaortic aneurysm

LRP1 FBN1

8.84e-0510422EFO_0001666
Diseaseautoimmune thyroiditis (is_implicated_in)

LRP2 TG

1.29e-0412422DOID:7188 (is_implicated_in)
Diseaseatrial fibrillation (is_implicated_in)

ISL1 VWF

1.78e-0414422DOID:0060224 (is_implicated_in)
DiseaseProteinuria

LRP2 VWF

2.05e-0415422HP_0000093
Diseaseupper face morphology measurement

MACF1 LMX1B WNT9B

3.60e-0497423EFO_0010949
DiseaseDrugs used in diabetes use measurement

NSD1 MACF1 LTK MYCBP2

4.71e-04255424EFO_0009924
Diseasecongenital heart disease (is_implicated_in)

ISL1 NOTCH1

5.35e-0424422DOID:1682 (is_implicated_in)
DiseaseEndogenous Hyperinsulinism

MRC1 FBN1

6.29e-0426422C1257963
DiseaseExogenous Hyperinsulinism

MRC1 FBN1

6.29e-0426422C1257964
DiseaseCompensatory Hyperinsulinemia

MRC1 FBN1

6.29e-0426422C1257965
Diseasecorpus callosum mid-anterior volume measurement

ZDHHC5 TG

6.79e-0427422EFO_0010297
DiseaseHyperinsulinism

MRC1 FBN1

7.30e-0428422C0020459
Diseasespontaneous coronary artery dissection

LRP1 FBN1

8.96e-0431422EFO_0010820
Diseasepack-years measurement, systolic blood pressure

LRP2 LRP1B

1.08e-0334422EFO_0006335, EFO_0006526

Protein segments in the cluster

PeptideGeneStartEntry
NLFEKTHCDCNVDWC

APBB1IP

206

Q7Z5R6
QSLSLQRCCHVDDWC

DMAC2

151

Q9NW81
NSWHIDFGRCCCHQN

CD163L1

6

Q9NR16
HCCQPNCETQKWSVN

NSD1

2021

Q96L73
DKWQAVLQDCIRHCN

NIBAN2

181

Q96TA1
NLSANPWHCDCALQE

LRRC3C

156

A6NJW4
KVCSLQCNNHACGWD

NOTCH1

1461

P46531
FQCKNNNCIPDHWRC

LRP1B

3481

Q9NZR2
HCKLLSINCLNEEWC

EYS

411

Q5T1H1
QQRWLHCDACEDVCD

NGLY1

346

Q96IV0
CQNHRCISKQWLCDG

LRP1

2741

Q07954
NTNDCHWCNDHCVPR

ATRN

716

O75882
QSNCWLCEHLDNAEQ

ERVMER34-1

41

Q9H9K5
VLQCDLCQDWFHGQC

KDM5D

1186

Q9BY66
CSHCPLRDCQWQAEL

LTK

381

P29376
NDSFWHEQCVQCASC

LMX1A

51

Q8TE12
CINNHVFCSICIDLW

OBI1

31

Q5W0B1
CDNHQCISKNWVCDT

LRP2

1116

P98164
FHCDNGNCIHRAWLC

LRP2

1276

P98164
WHDTCFVCAICQINL

PDLIM7

421

Q9NR12
LIHLQANSNPWECNC

LRRC70

351

Q7Z2Q7
QNTCHQQLEDLCSWV

MACF1

3616

Q9UPN3
GQRWHENHFCCQDCA

PRICKLE4

166

Q2TBC4
QWNQCVDENECLSAH

FBN1

2601

P35555
GHWQCHNCQTCALLQ

IQCF2

131

Q8IXL9
TCLQCHLCFDQWDHT

LAMB4

1171

A4D0S4
QACCVQSEKHWAAAQ

H6PD

376

O95479
IQCEECLCWQHSVCM

PHF20L1

696

A8MW92
MIQCEECQCWQHGVC

PHF20

666

Q9BVI0
DINCEHLNNWICQIQ

MRC1

766

P22897
LELDNCNLTSHCCWD

NLRP3

946

Q96P20
CANQCPHSCADLWDR

SSPOP

4681

A2VEC9
CQDLTWLCIHQACPE

KCP

1111

Q6ZWJ8
WACLCDLLNCLDQDI

MYCBP2

1561

O75592
LEWHAACLKCAECNQ

ISL1

36

P61371
CQDRKWNCTDHVCDA

VWF

851

P04275
CRQWFHEACTQCLNE

PHF19

216

Q5T6S3
WENHHNSECARCQAC

TNFRSF25

81

Q93038
CVEEFDHHCPWVNNC

ZDHHC5

126

Q9C0B5
KVDECNICHCHNGDW

VWC2L

191

B2RUY7
CVEDFDHHCPWVNNC

ZDHHC8

126

Q9ULC8
CHCQVQWCCYVECQQ

WNT9B

331

O14905
QWCCYVECQQCVQEE

WNT9B

336

O14905
LWCLSRCVQEHSFCQ

TG

1891

P01266
WHEECLQCAACQQAL

LMX1B

76

O60663
LNADWHADCFRCCDC

LIMK1

41

P53667