Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of skin epidermis	SPRR1B SPRR2A SPRR2B SPRR2E SPRR2F	7.95e-08	43	51	5	GO:0030280
GeneOntologyBiologicalProcess	keratinization	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G LCE3C	5.47e-11	87	53	8	GO:0031424
GeneOntologyBiologicalProcess	epidermal cell differentiation	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E GLI2 SPRR2F SPRR2G PITX2 SLITRK6 LCE3C	1.27e-10	284	53	11	GO:0009913
GeneOntologyBiologicalProcess	epidermis development	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E GLI2 SPRR2F SPRR2G PITX2 SLITRK6 LCE3C	2.02e-08	461	53	11	GO:0008544
GeneOntologyBiologicalProcess	keratinocyte differentiation	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G LCE3C	2.67e-08	189	53	8	GO:0030216
GeneOntologyBiologicalProcess	epithelial cell differentiation	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E GLI2 SPRR2F SPRR2G PITX2 SLITRK6 CDH2 JMJD1C LCE3C	2.15e-07	870	53	13	GO:0030855
GeneOntologyBiologicalProcess	skin development	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E GLI2 SPRR2F SPRR2G LCE3C	4.13e-07	373	53	9	GO:0043588
GeneOntologyBiologicalProcess	epithelium development	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E GLI2 SPRR2F SPRR2G PITX2 SLITRK6 CDH2 JMJD1C SMAD1 LCE3C	1.40e-05	1469	53	14	GO:0060429
GeneOntologyBiologicalProcess	developmental process involved in reproduction	CFAP47 SPATA31A1 SPATA31A3 GLI2 SPATA31A7 DACH1 AHSG ZDBF2 DZIP1 SPATA31A6 SPATA31A5 JMJD1C	5.44e-05	1235	53	12	GO:0003006
GeneOntologyBiologicalProcess	gamete generation	CFAP47 SPATA31A1 SPATA31A3 SPATA31A7 ZDBF2 DZIP1 SPATA31A6 SPATA31A5 FIGNL1 SMAD1	1.72e-04	982	53	10	GO:0007276
GeneOntologyBiologicalProcess	response to estradiol	SPRR2A SPRR2B SPRR2E SPRR2F	3.27e-04	128	53	4	GO:0032355
GeneOntologyCellularComponent	cornified envelope	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	4.89e-10	69	54	7	GO:0001533
GeneOntologyCellularComponent	acrosomal vesicle	KIAA1210 SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	1.48e-05	206	54	6	GO:0001669
GeneOntologyCellularComponent	secretory granule	KIAA1210 SPATA31A1 SPATA31A3 SPRR2A SPRR2B SPRR2E SPRR2F SPATA31A7 AHSG SPATA31A6 SPATA31A5	4.65e-05	1014	54	11	GO:0030141
GeneOntologyCellularComponent	secretory vesicle	KIAA1210 SPATA31A1 SPATA31A3 SPRR2A SPRR2B SPRR2E SPRR2F SPATA31A7 AHSG SPATA31A6 SPATA31A5	2.88e-04	1246	54	11	GO:0099503
GeneOntologyCellularComponent	nuclear speck	GLI2 KAT6A DACH1 ZNF638 HBP1 DZIP1	8.30e-04	431	54	6	GO:0016607
MousePheno	abnormal eye distance/ position	TPO TET1 PITX2 LPAR1	3.17e-05	80	32	4	MP:0001299
Domain	SPRR2	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	3.90e-16	6	53	6	IPR029142
Domain	SPRR2	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	3.90e-16	6	53	6	PF14820
Domain	SPRR/LCE	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F PRR9 LCE3C	7.20e-15	28	53	8	IPR026075
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	2.81e-08	12	53	4	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	2.81e-08	12	53	4	IPR027970
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G LCE3C	9.64e-10	129	36	8	M27649
Pathway	REACTOME_KERATINIZATION	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G LCE3C	5.79e-08	217	36	8	M27640
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G EIF4G1 ZNF638 CDH2 SMAD1 LCE3C	1.41e-04	1432	36	12	M509
Pubmed	Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins.	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	1.74e-18	10	54	7	8325635
Pubmed	Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues.	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	1.14e-17	12	54	7	9888996
Pubmed	Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	1.14e-17	12	54	7	18643845
Pubmed	Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus.	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	2.94e-16	8	54	6	15232223
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	4.47e-14	6	54	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	4.47e-14	6	54	5	25930072
Pubmed	Mouse Sprr locus: a tandem array of coordinately regulated genes.	SPRR1B SPRR2A SPRR2B SPRR2E SPRR2F	4.16e-13	8	54	5	12584609
Pubmed	Long-range comparison of human and mouse Sprr loci to identify conserved noncoding sequences involved in coordinate regulation.	SPRR1B SPRR2A SPRR2B SPRR2E SPRR2F	4.16e-13	8	54	5	15574822
Pubmed	Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.	SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	9.36e-13	9	54	5	11279051
Pubmed	Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes.	SPRR1B SPRR2B SPRR2D SPRR2E	2.59e-11	5	54	4	3133554
Pubmed	Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression.	SPRR2A SPRR2B SPRR2E SPRR2F	1.81e-10	7	54	4	31884525
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	3.10e-10	24	54	5	32212159
Pubmed	Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein.	SPRR2A SPRR2B SPRR2E SPRR2F	3.62e-10	8	54	4	11038185
Pubmed	Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development.	SPRR1B SPRR2A SPRR2B SPRR2E SPRR2F	3.87e-10	25	54	5	31410202
Pubmed	ZFP750 affects the cutaneous barrier through regulating lipid metabolism.	SPRR1B SPRR2A SPRR2B SPRR2E SPRR2F	1.23e-09	31	54	5	37115925
Pubmed	The mineralocorticoid receptor plays a transient role in mouse skin development.	SPRR2A SPRR2B SPRR2E SPRR2F	3.67e-09	13	54	4	26268211
Pubmed	Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern.	SPRR2A SPRR2B SPRR2E SPRR2F	5.13e-09	14	54	4	19301398
Pubmed	Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero.	SPRR2A SPRR2B SPRR2E SPRR2F	5.13e-09	14	54	4	23237955
Pubmed	Glucocorticoid receptor regulates overlapping and differential gene subsets in developing and adult skin.	SPRR2A SPRR2B SPRR2E SPRR2F	6.99e-09	15	54	4	20880987
Pubmed	Expression and regulation of cornified envelope proteins in human corneal epithelium.	SPRR2A SPRR2B SPRR2D	1.41e-08	4	54	3	16639001
Pubmed	XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes.	SPRR2A SPRR2B SPRR2E SPRR2F	2.47e-08	20	54	4	21466799
Pubmed	The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.	SPRR2A SPRR2B SPRR2E SPRR2F	3.72e-08	22	54	4	16949565
Pubmed	Simultaneous gene deletion of gata4 and gata6 leads to early disruption of follicular development and germ cell loss in the murine ovary.	SPRR2A SPRR2B SPRR2E SPRR2F	3.72e-08	22	54	4	24899573
Pubmed	A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.	SPRR2A SPRR2B SPRR2E SPRR2F LCE3C	4.51e-08	62	54	5	26644517
Pubmed	Ovarian development in mice requires the GATA4-FOG2 transcription complex.	SPRR2A SPRR2B SPRR2E SPRR2F	2.95e-07	36	54	4	18927154
Pubmed	New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation.	SPRR2A SPRR2B SPRR2E SPRR2F	4.55e-07	40	54	4	19864314
Pubmed	Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2.	HSPG2 PITX2 CDH2	1.95e-06	16	54	3	17767158
Pubmed	RNA sequencing and pathway analysis identify tumor necrosis factor alpha driven small proline-rich protein dysregulation in chronic rhinosinusitis.	SPRR1B SPRR2A	2.37e-06	2	54	2	28859701
Pubmed	Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.	SPRR2A SPRR2B SPRR2E SPRR2F	2.37e-06	60	54	4	31220272
Pubmed	RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1.	GLI2 PITX2 SMAD1	3.96e-06	20	54	3	32662771
Pubmed	Angiomotin like-1 is a novel component of the N-cadherin complex affecting endothelial/pericyte interaction in normal and tumor angiogenesis.	AMOTL1 CDH2	7.09e-06	3	54	2	27464479
Pubmed	Structural and transglutaminase substrate properties of the small proline-rich 2 family of cornified cell envelope proteins.	SPRR2B SPRR2E	7.09e-06	3	54	2	9722562
Pubmed	Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner.	GLI2 CDH2 SMAD1	7.94e-06	25	54	3	18927156
Pubmed	Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.	SPRR2A SPRR2B SPRR2E SPRR2F EIF4G1	1.40e-05	197	54	5	32434143
Pubmed	Perlecan is critical for heart stability.	HSPG2 CDH2	1.42e-05	4	54	2	18694874
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	HSPG2 PHF3 GLI2 TET1 JMJD1C	1.62e-05	203	54	5	22083510
Pubmed	Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.	HSPG2 GLI2 SMAD1	2.24e-05	35	54	3	18676816
Pubmed	Midline craniofacial malformations with a lipomatous cephalocele are associated with insufficient closure of the neural tube in the tuft mouse.	TET1 CDH2	2.36e-05	5	54	2	24931720
Pubmed	Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis.	PITX2 CDH2	2.36e-05	5	54	2	21726547
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G GON4L LCE3C	2.74e-05	1031	54	9	16710414
Pubmed	Mesodermal expression of Moz is necessary for cardiac septum development.	KAT6A PITX2	4.94e-05	7	54	2	25912687
Pubmed	BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression.	GLI2 SMAD1	4.94e-05	7	54	2	19505455
Pubmed	Cnn3 regulates neural tube morphogenesis and neuronal stem cell properties.	CDH2 SMAD1	4.94e-05	7	54	2	29151265
Pubmed	Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells.	DACH1 CDH2 SMAD1	5.12e-05	46	54	3	25182747
Pubmed	Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row.	PITX2 SMAD1	6.59e-05	8	54	2	19251632
Pubmed	Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.	CDH2 SMAD1	6.59e-05	8	54	2	22152476
Pubmed	Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2.	GLI2 SMAD1	8.46e-05	9	54	2	19103752
Pubmed	Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures.	HSPG2 CDH2	8.46e-05	9	54	2	18816447
Pubmed	Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.	PITX2 CDH2 SMAD1	8.77e-05	55	54	3	28807898
Pubmed	Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.	PITX2 ZNF347 HBP1	1.14e-04	60	54	3	18023262
Pubmed	Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.	AMOTL1 CDH2	1.29e-04	11	54	2	28239148
Pubmed	Mechanical feedback defines organizing centers to drive digit emergence.	CDH2 SMAD1	1.29e-04	11	54	2	35413235
Pubmed	Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure.	GLI2 CDH2	1.29e-04	11	54	2	33103996
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	PHF3 AMOTL1 ZNF638 UBAP1 ZDBF2 RWDD4 JMJD1C	1.34e-04	733	54	7	34672954
Pubmed	Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis.	AMOTL1 SMAD1	1.55e-04	12	54	2	32698004
Pubmed	Deletion of Lrp4 increases the incidence of microphthalmia.	GLI2 PITX2 SMAD1	1.72e-04	69	54	3	30352686
Pubmed	Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development.	PITX2 SMAD1	1.83e-04	13	54	2	19631205
Pubmed	BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment.	PITX2 SMAD1	1.83e-04	13	54	2	18550712
Pubmed	Ontogenesis of the tear drainage system requires Prickle1-driven polarized basement membrane deposition.	HSPG2 CDH2	1.83e-04	13	54	2	33144400
Pubmed	Lrp4 modulates extracellular integration of cell signaling pathways in development.	GLI2 SMAD1	2.13e-04	14	54	2	19116665
Pubmed	Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.	PITX2 SMAD1	2.13e-04	14	54	2	23250216
Pubmed	Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.	HSPG2 GLI2	2.13e-04	14	54	2	19783738
Pubmed	A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.	PWWP3B MBD5	2.13e-04	14	54	2	26912663
Pubmed	Primary Cilium in Neural Crest Cells Crucial for Anterior Segment Development and Corneal Avascularity.	PITX2 CDH2	2.45e-04	15	54	2	38517430
Pubmed	Teeth. Where and how to make them.	GLI2 PITX2	2.45e-04	15	54	2	10098408
Pubmed	ALK5-mediated transforming growth factor β signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions.	PITX2 SMAD1	2.45e-04	15	54	2	24912677
Pubmed	Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway.	GLI2 PITX2	2.45e-04	15	54	2	24780629
Pubmed	Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2).	GLI2 SMAD1	2.45e-04	15	54	2	22547067
Pubmed	Creation of genome-wide protein expression libraries using random activation of gene expression.	CFAP47 SPRR2D SPRR2E CDH2 CREB5	2.63e-04	367	54	5	11329013
Pubmed	Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein.	HSPG2 PITX2	3.17e-04	17	54	2	20970343
Pubmed	Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium.	PITX2 SMAD1	3.17e-04	17	54	2	18667074
Pubmed	Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool.	DACH1 CDH2	3.17e-04	17	54	2	18521945
Pubmed	MOZ directs the distal-less homeobox gene expression program during craniofacial development.	KAT6A PITX2	3.17e-04	17	54	2	31340933
Pubmed	Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis.	PITX2 SMAD1	3.17e-04	17	54	2	18832393
Pubmed	Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.	PITX2 CDH2	3.17e-04	17	54	2	20040491
Pubmed	Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation.	PITX2 SMAD1	3.56e-04	18	54	2	32105214
Pubmed	Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract.	PITX2 SMAD1	3.56e-04	18	54	2	17601530
Pubmed	Threshold-specific requirements for Bmp4 in mandibular development.	PITX2 SMAD1	3.56e-04	18	54	2	15936012
Pubmed	BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4.	PITX2 SMAD1	3.98e-04	19	54	2	18981480
Pubmed	alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway.	GLI2 CDH2	3.98e-04	19	54	2	16543460
Pubmed	The Role of Sorting Nexin 17 in Cardiac Development.	PITX2 CDH2	3.98e-04	19	54	2	34988124
Pubmed	Probing transcription-specific outputs of β-catenin in vivo.	CDH2 SMAD1	3.98e-04	19	54	2	22190459
Pubmed	Persistent Wnt/β-catenin signaling in mouse epithelium induces the ectopic Dspp expression in cheek mesenchyme.	PITX2 SMAD1	4.42e-04	20	54	2	30570432
Pubmed	MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome.	KAT6A PITX2	4.42e-04	20	54	2	22921202
Pubmed	Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning.	CDH2 SMAD1	4.42e-04	20	54	2	29412136
Pubmed	Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.	HSPG2 AHSG CDH2	4.70e-04	97	54	3	27559042
Pubmed	Control of lens development by Lhx2-regulated neuroretinal FGFs.	CDH2 SMAD1	4.88e-04	21	54	2	27633990
Pubmed	Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration.	SPRR1B GLI2	4.88e-04	21	54	2	24198274
Pubmed	Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis.	GLI2 SMAD1	4.88e-04	21	54	2	32855417
Pubmed	ESCRT-I protein UBAP1 controls ventricular expansion and cortical neurogenesis via modulating adherens junctions of radial glial cells.	UBAP1 CDH2	4.88e-04	21	54	2	38402586
Pubmed	A census of human transcription factors: function, expression and evolution.	ZNF268 GLI2 PITX2 GON4L HBP1 CREB5 SMAD1	4.92e-04	908	54	7	19274049
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G EIF4G1	4.98e-04	910	54	7	36736316
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	DLGAP3 PHF3 GLI2 EIF4G1 CDH2 JMJD1C ABHD16A CREB5	5.07e-04	1203	54	8	29180619
Pubmed	TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors.	PITX2 SMAD1	5.36e-04	22	54	2	17919533
Pubmed	β1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation.	CDH2 SMAD1	5.36e-04	22	54	2	38794925
Pubmed	Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation.	SORCS2 CDH2	5.36e-04	22	54	2	14645517
Pubmed	Rap1 controls epiblast morphogenesis in sync with the pluripotency states transition.	CDH2 SMAD1	5.86e-04	23	54	2	35998584
Pubmed	Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.	ZNF638 SMAD1	5.86e-04	23	54	2	30779601
Pubmed	Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.	HSPG2 GLI2	5.86e-04	23	54	2	30814516
Pubmed	Differentially expressed late constituents of the epidermal cornified envelope.	SPRR1B LCE3C	5.86e-04	23	54	2	11698679
Interaction	PTK6 interactions	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	2.16e-07	104	50	6	int:PTK6
Cytoband	1q21-q22	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	5.02e-16	23	54	7	1q21-q22
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G PRR9 LCE3C	1.09e-09	404	54	9	chr1q21
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	3.79e-05	8	54	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	3.69e-04	24	54	2	9p13.1
Cytoband	3q27	EIF4G1 AHSG	4.00e-04	25	54	2	3q27
GeneFamily	Small proline rich proteins	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	2.19e-17	11	36	7	1353
GeneFamily	PWWP domain containing	PWWP3B MBD5	8.68e-04	22	36	2	1147
GeneFamily	PHD finger proteins	PHF3 KAT6A	1.38e-02	90	36	2	88
Coexpression	HUMMERICH_BENIGN_SKIN_TUMOR_UP	SPRR2A SPRR2B SPRR2E SPRR2F	6.52e-08	20	52	4	MM491
Coexpression	HUMMERICH_MALIGNANT_SKIN_TUMOR_UP	SPRR2A SPRR2B SPRR2E SPRR2F	1.19e-07	23	52	4	MM492
Coexpression	MARTINEZ_RB1_TARGETS_UP	TPO SPRR1B SPRR2A SPRR2B SPRR2E SPRR2F EIF4G1 HBP1 SMAD1	1.36e-05	741	52	9	MM1037
Coexpression	GSE29164_UNTREATED_VS_CD8_TCELL_TREATED_MELANOMA_DAY7_DN	LENG8 SPRR2A GLI2 AHSG PRR9	4.78e-05	200	52	5	M8496
Coexpression	MARTINEZ_RB1_AND_TP53_TARGETS_UP	SPRR1B SPRR2A SPRR2B SPRR2E SPRR2F PITX2 EIF4G1 HBP1	5.93e-05	689	52	8	MM1041
Coexpression	MARTINEZ_TP53_TARGETS_UP	SPRR1B SPRR2A SPRR2B SPRR2E SPRR2F PITX2 EIF4G1 HBP1	6.24e-05	694	52	8	MM1039
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#3_top-relative-expression-ranked_1000	DACH1 DZIP1 SLITRK6 CDH2 RWDD4 LPAR1 SMAD1	5.52e-07	196	53	7	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k3_1000
CoexpressionAtlas	esophagus	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	3.39e-05	247	53	6	esophagus
CoexpressionAtlas	JC_iEC_top-relative-expression-ranked_2500_k-means-cluster#4	SLC7A4 SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	4.36e-05	382	53	7	JC_iEC_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_1000_k-means-cluster#1	PHF3 TET1 DACH1 ZNF638 ZDBF2 CDH2	4.41e-05	259	53	6	Facebase_RNAseq_e8.5_Floor Plate_1000_K1
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_k-means-cluster#5_top-relative-expression-ranked_1000	GLI2 SORCS2 ANKRD12 DZIP1 LPAR1 SMAD1	7.94e-05	288	53	6	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_1000_k5
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_k-means-cluster#3_top-relative-expression-ranked_500	GLI2 SORCS2 PWWP3B DZIP1 CDH2	1.05e-04	188	53	5	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_500_k3
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_reference_BronchioEpithel_top-relative-expression-ranked_100	SPRR1B SPRR2A SPRR2B SPRR2D	1.05e-04	98	53	4	PCBC_ctl_BronchioEpithel_100
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#1_top-relative-expression-ranked_1000	GLI2 DACH1 DZIP1 CDH2 LPAR1	1.19e-04	193	53	5	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000_k1
ToppCell	TCGA-Head_and_Esophagus\|World / Sample_Type by Project: Shred V9	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	1.61e-09	172	54	7	eb18aa179db1818f408c38e442ecfed8582d7dbc
ToppCell	PSB-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	2.47e-09	183	54	7	2cf798a2371c61322484ea16fdfae0acfa94f102
ToppCell	NS-moderate-d_07-13\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	3.84e-09	195	54	7	088209505a68519ec89f50f0576096da6966bf17
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	3.98e-09	196	54	7	03de28e1c963e99623e8b0e33bf2e8ef67dc3baa
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic-leukocyte\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	4.13e-09	197	54	7	e621d4f9d4ba5e3ef17d2b477e5e14ea0251147e
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G CDH2	4.13e-09	197	54	7	7870c0651caefb0ed13d9f9dab43b5f24d6a9efc
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-leukocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	4.13e-09	197	54	7	d968d7d5608b175bb567ea3a315bf473ec3be459
ToppCell	NS-moderate-d_07-13-Epithelial-Squamous\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G	4.27e-09	198	54	7	b7495369baba203490c067a58fc8456a778a12e4
ToppCell	Bronchial_Brush-Epithelial-Ciliated_2\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	1.31e-08	132	54	6	780a391924f776dc6fbe44ddcf4ae0583a1e2157
ToppCell	Bronchial_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	1.50e-08	135	54	6	366a417f9ef7c0d86e9f262d97bf788f478315ee
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-6\|TCGA-Bladder / Sample_Type by Project: Shred V9	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	6.13e-08	171	54	6	0e78389f8f3d54570a6deb3dd307b865b46307e9
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	8.04e-08	179	54	6	2b5f8e109a67c7fc3ec2b83e8f1854160c99283a
ToppCell	TCGA-Skin-Primary_Tumor\|TCGA-Skin / Sample_Type by Project: Shred V9	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2G	1.14e-07	190	54	6	e2b26a03c6ab24d9b0f4150c47597be37767d86e
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2G	1.14e-07	190	54	6	01fb45add4661bc86cd0a34fac35177907152dbb
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2G	1.14e-07	190	54	6	3188c7bd225cbcf46a21e2fb784336cdd9665995
ToppCell	NS-moderate-d_16-33-Epithelial-Squamous\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	1.22e-07	192	54	6	103496f428f59683ac3ae6147682c07c30663724
ToppCell	NS-critical-d_07-13-Epithelial-Squamous\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	1.29e-07	194	54	6	53a34843d529ef395deb27086f71f7049a087bab
ToppCell	critical-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	1.42e-07	197	54	6	cfbdaada7169afb68455724ae87032ff311b2d89
ToppCell	NS-control-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	1.42e-07	197	54	6	ab965a0ba87efd3329d24a1ec123985f46fc17c0
ToppCell	moderate-Epithelial-Squamous\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	1.42e-07	197	54	6	ab3c90a5b643b45d0b83939c6304b11f567c5d78
ToppCell	critical-Epithelial-Squamous\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	1.42e-07	197	54	6	eccc80d6ab79c46b10108de1cff3abeacfc105cd
ToppCell	moderate-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F	1.42e-07	197	54	6	2e13881f917d4f62a5b3e968e41c57e43300d988
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-2\|TCGA-Brain / Sample_Type by Project: Shred V9	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2G	7.33e-07	139	54	5	6f6c64eaa1ce84e0aa9a0caa9c4d9bf7afe626df
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_2\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRR1B SPRR2A SPRR2D SPRR2E SPRR2F	1.18e-06	153	54	5	b25629953ff79aff645845376132b12023067b01
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRR1B SPRR2A SPRR2D SPRR2E SPRR2F	1.18e-06	153	54	5	e9d6b4e895ddb8d6e6c8b043da591ec11365e124
ToppCell	Ciliated_cells-A-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	SPRR2A SPRR2E SPRR2G DZIP1 CDH2	1.61e-06	163	54	5	43194c6127df1ce3d29242f719645de3c11fd7c0
ToppCell	NS-moderate-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1B SPRR2A SPRR2D SPRR2E SPRR2F	1.92e-06	169	54	5	4a5d023ffcf83312d29b1d215eb6b744ef1a0777
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLC7A4 SPRR2B SPRR2F PRR9 PWWP3B	2.41e-06	177	54	5	0912a291cff32a4ff8a2d7680ed1a1cd867fb90f
ToppCell	NS\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1B SPRR2A SPRR2D SPRR2E SPRR2F	2.62e-06	180	54	5	8472dcce7bc0b7ce428ec17ddf0018f3258f78d2
ToppCell	tumor_Lung-Fibroblasts-Mesothelial_cells\|tumor_Lung / Location, Cell class and cell subclass	SPRR2A SPRR2B SPRR2F PRR9 PWWP3B	2.91e-06	184	54	5	b0a251030d127858e68cf164be158f209a4d720f
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma-6\|TCGA-Skin / Sample_Type by Project: Shred V9	SPRR1B SPRR2A SPRR2B SPRR2E SPRR2G	3.15e-06	187	54	5	2ca7928baf0c5e61f7294ed05e6e6f0e0adf9d3f
ToppCell	wk_15-18-Mesenchymal-Mesothelial-Late_mesothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SLC7A4 SPRR2A SPRR2B SPRR2E SPRR2F	3.24e-06	188	54	5	38a53f99f1876359983936403aefca93281d10fd
ToppCell	tumor_Lung-Fibroblasts-Mesothelial_cells\|Fibroblasts / Location, Cell class and cell subclass	SPRR2A SPRR2B SPRR2F PRR9 PWWP3B	3.41e-06	190	54	5	d82ab67735c1f365d4b0e02b5fa91c64cdc234da
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1B SPRR2A SPRR2D SPRR2F ABHD16A	3.49e-06	191	54	5	529068029fb461df766135576dd0d8b5980f9bc0
ToppCell	NS-critical-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1B SPRR2A SPRR2D SPRR2E SPRR2F	3.77e-06	194	54	5	614d0c25b56957c70f397abb169fd2a860eb1c06
ToppCell	NS-critical-d_16-33-Epithelial-Squamous\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1B SPRR2A SPRR2D SPRR2E SPRR2F	3.96e-06	196	54	5	97e16d9833e4083d719ca7058d5fc9b11edb37e3
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1B SPRR2A SPRR2D SPRR2E SPRR2F	4.06e-06	197	54	5	fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1B SPRR2A SPRR2D SPRR2E SPRR2F	4.06e-06	197	54	5	2430f31d9312338e0ca23bfc6bdb0365340860fd
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1B SPRR2A SPRR2D SPRR2E SPRR2F	4.06e-06	197	54	5	61c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1B SPRR2A SPRR2D SPRR2E SPRR2F	4.06e-06	197	54	5	dcabea5c50c133c9a4e294e447462d0393174ea7
ToppCell	control-Epithelial-Squamous\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR1B SPRR2A SPRR2D SPRR2E SPRR2F	4.17e-06	198	54	5	6ba669ac1ed275ae309054941b1457e315766faa
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1B SPRR2A SPRR2D SPRR2E SPRR2F	4.17e-06	198	54	5	e06d41a7254a09e037ec404be2d8c352d5cbd7f4
ToppCell	control-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR1B SPRR2A SPRR2D SPRR2E SPRR2F	4.27e-06	199	54	5	e13dca7a055cdca53dd6c26c04b2a46d58b419b6
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Metaplastic_Carcinoma-2\|TCGA-Breast / Sample_Type by Project: Shred V9	SPRR2D SPRR2G PRR9 LCE3C	4.79e-06	92	54	4	cad8b1b74a412988b2ae4f6126b2186100a2cdc2
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Metaplastic_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	SPRR2A SPRR2B SPRR2D SPRR2E	1.51e-05	123	54	4	51e49a64fbbf77e2ee21f45fd515d43282b11516
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Metaplastic_Carcinoma-4\|TCGA-Breast / Sample_Type by Project: Shred V9	SPRR2A SPRR2B SPRR2D SPRR2E	1.51e-05	123	54	4	11802979943a9205f10facda322fc220d4bf7133
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Undifferentiated_Pleomorphic_Sarcoma-4\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	SPRR2B SPRR2E SPRR2F CREB5	1.94e-05	131	54	4	2ccf679b5035b7b9cdb9a9a660cad90288592187
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-4\|TCGA-Stomach / Sample_Type by Project: Shred V9	SPRR2A SPRR2D SPRR2E SPRR2F	4.56e-05	163	54	4	6a12b802cb181f979ebc72674f3626fb855024e3
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPRR1B SPRR2A SPRR2D SPRR2E	4.89e-05	166	54	4	006ced12f69ef13ddcba5a3891ddc7c18c384863
ToppCell	Bronchial_Brush-Epithelial-Goblet_2\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRR1B SPRR2A SPRR2E SPRR2F	4.89e-05	166	54	4	8ac0a769be886d16642e7e6334471ebadd1a426b
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPRR1B SPRR2A SPRR2D SPRR2E	4.89e-05	166	54	4	ac28c8cac1e94be0c47fb862c5809c92cdaa11f3
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SPRR1B SPRR2A SPRR2D SPRR2E	4.89e-05	166	54	4	6bb3410e65c971acc458c472015afcec6de6e310
ToppCell	Control-Epithelial-Mesothelial\|Control / Disease state, Lineage and Cell class	SLC7A4 SPRR2B SPRR2F PRR9	4.89e-05	166	54	4	1ed3788257e14f097862b999f020bfe2a57de52b
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPRR1B SPRR2A SPRR2D SPRR2E	4.89e-05	166	54	4	823ec03714884cb860a1260410feac8c536b6d06
ToppCell	Bronchial_Brush-Epithelial-Goblet_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRR1B SPRR2A SPRR2E SPRR2F	5.01e-05	167	54	4	806d1c00c137da0c5f042adf866873eb6dd4bb27
ToppCell	normal_Lung-Fibroblasts-Mesothelial_cells\|Fibroblasts / Location, Cell class and cell subclass	SPRR2B SPRR2D SPRR2F PWWP3B	5.01e-05	167	54	4	892a2dc83ab5de5a1016402f8e95d2aabf651326
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AMOTL1 DACH1 PWWP3B SLITRK6	5.13e-05	168	54	4	217770a94ace446cdfc7687b459dece707576e76
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D231\|Adult / Lineage, Cell type, age group and donor	TPO ADCY4 SNPH DACH1	5.13e-05	168	54	4	aca34c51758c65925ad24110294a72b2dea6db72
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1B SPRR2A SPRR2B SPRR2F	5.37e-05	170	54	4	13a225e32132e9717debb0d64d7c28ada974c3e6
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LENG8 SPRR1B SPRR2A SPRR2D	5.88e-05	174	54	4	207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DLGAP3 FIGNL1 CREB5 SMAD1	6.14e-05	176	54	4	a9e77681bcd36c382d53eb6f771349d55f98d744
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-5\|TCGA-Lung / Sample_Type by Project: Shred V9	SPRR1B SPRR2A SPRR2D SPRR2E	6.28e-05	177	54	4	a0c7d08469c513cecf87777c19876884f1511570
ToppCell	P28-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SORCS2 SLITRK6 CDH2 LPAR1	6.70e-05	180	54	4	1e819c5c87704ec6535dfeaae56561895e239d07
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORCS2 PWWP3B SLITRK6 CDH2	6.70e-05	180	54	4	8bf6e8b6b45ce42f8c5f23e7cd1752ec8b3fa2d2
ToppCell	droplet-Kidney-nan-3m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORCS2 SLITRK6 LPAR1 CREB5	6.85e-05	181	54	4	0b1e7335648823b1d83bdfa878ccd44efe7bba9a
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TPO SLC7A4 KCNU1 SPRR2G	7.30e-05	184	54	4	61caaa31975e05c9a6512079c791fed5a9e2d39f
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TPO SLC7A4 KCNU1 SPRR2G	7.30e-05	184	54	4	03da0f0f89f1ca5a3ccca1e22972f3129464e68e
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TPO SLC7A4 KCNU1 SPRR2G	7.30e-05	184	54	4	9ed2a65a4ca0ebbbb89ace61027522f93369843d
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHF3 KAT6A ZNF638 JMJD1C	7.30e-05	184	54	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1B SPRR2A SPRR2D SPRR2E	7.45e-05	185	54	4	f3fbc3096f85397a959cee17c3c4fcf2d511f3d5
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SPRR2F PRR9 PWWP3B CDH2	7.61e-05	186	54	4	7812ed80d2378aca9957ef22fc3c8fb7fb58434b
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	TPO HSPG2 ADCY4 PWWP3B	7.77e-05	187	54	4	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	SupraBC-Differ-KC\|World / shred by cell class for mouse tongue	SPRR1B SPRR2G PRR9 LCE3C	8.10e-05	189	54	4	6412741b88e241304033b41effca0c77a374d907
ToppCell	COVID-19-Heart-EC_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TPO HSPG2 ADCY4 DACH1	8.10e-05	189	54	4	fe49852ba15f948b384d6b4c258927c70b741357
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma\|TCGA-Lung / Sample_Type by Project: Shred V9	SPRR1B SPRR2A SPRR2D SPRR2E	8.10e-05	189	54	4	aa4f7d7a5196e5ae481ebc2549de8e3f0ef6e6be
ToppCell	BL-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1B SPRR2A SPRR2D SPRR2E	8.43e-05	191	54	4	3f9b8c4fb72ae6f3167b187e6715c4dcb3159f98
ToppCell	wk_15-18-Mesenchymal-Mesothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SLC7A4 SPRR2B SPRR2E SPRR2F	8.43e-05	191	54	4	b5374674312ff5803a1d369f5533027532344679
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1B SPRR2A SPRR2D SPRR2E	8.43e-05	191	54	4	fbd8d337b4444fba8527a614e4a8bfb516ce0f66
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1B SPRR2D SPRR2E SPRR2F	8.60e-05	192	54	4	24fb2f1e6f49ab5b71876e105c0ee7f59e7d64e8
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRR1B SPRR2B SPRR2G LCE3C	8.78e-05	193	54	4	f074ebf9c5c53d8589d66b0109505f30baa1af81
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR2B SPRR2F PRR9 PWWP3B	8.95e-05	194	54	4	f4286ae7bb8350c42d50727ee8688b80129714f6
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR2B SPRR2F PRR9 PWWP3B	8.95e-05	194	54	4	87461bd6d7f702c0a0f5e0c8ace3049125a51f9a
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR2B SPRR2F PRR9 PWWP3B	8.95e-05	194	54	4	c578cf7c6b4d6f31f87dde8845de5b3891f16822
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-squamous_epithelial_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPRR1B SPRR2A SPRR2D SPRR2E	9.13e-05	195	54	4	82d87fdb39ec15be9057e2d2ba5c1afb5f97aafe
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPRR1B SPRR2A SPRR2D SPRR2E	9.13e-05	195	54	4	dd8117dbd22892288f74a7314ab0b5080106936c
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPO HSPG2 ADCY4 SMAD1	9.13e-05	195	54	4	527a5a50d6e2cbbbd64d11609e5cde2e33f14797
ToppCell	ILEUM-non-inflamed-(9)_Neuro_cell\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SLITRK6 CDH2 LPAR1 CREB5	9.32e-05	196	54	4	2b08cd6730119d5dea0152709ab8de580b66cd3c
ToppCell	NS-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1B SPRR2A SPRR2D SPRR2E	9.32e-05	196	54	4	453c809494ceffa2a28af283c4b5a4924fcf160f
ToppCell	ILEUM-non-inflamed-(9)_Enteric_neurons\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SLITRK6 CDH2 LPAR1 CREB5	9.32e-05	196	54	4	998aa523555ed6bc9c1b5cacbf7ba77c7b218e6b
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC7A4 SPRR2B SPRR2F PRR9	9.32e-05	196	54	4	147dc1ca5942df48a083cce39a9a7541430f8365
ToppCell	COPD-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	SPRR2A SPRR2D UBAP1 LPAR1	9.32e-05	196	54	4	af96fb94886e9395f3e2cd0a293af29229d017fe
ToppCell	5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPO HSPG2 ADCY4 AMOTL1	9.50e-05	197	54	4	87eda06344498dc66cac292cf89746dc90b5cf67
ToppCell	356C-Endothelial_cells\|356C / Donor, Lineage, Cell class and subclass (all cells)	HSPG2 ADCY4 DACH1 SMAD1	9.50e-05	197	54	4	f20eda534b2b28986790b28ce150ca3ba067593a
ToppCell	Parenchymal-10x5prime-Stromal-Mesofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SPRR2F PRR9 PWWP3B CDH2	9.50e-05	197	54	4	88a86286b9c3ea3b076d7464faec42d0392ee7f8
ToppCell	Parenchymal-10x5prime-Stromal-Mesofibroblastic-Mesothelia\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SPRR2F PRR9 PWWP3B CDH2	9.50e-05	197	54	4	2773d2eb5f232a7e49da116efffcb6bf5eb90810
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPRR1B SPRR2A SPRR2D SPRR2E	9.50e-05	197	54	4	ac9c0c25cfeaabd53d332982c73fc6c47b0c6478
ToppCell	LV-09._Endothelium_I\|LV / Chamber and Cluster_Paper	TPO HSPG2 ADCY4 DACH1	9.50e-05	197	54	4	f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell	distal-Epithelial-Basal-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPRR1B SPRR2A SPRR2D PITX2	9.50e-05	197	54	4	75b4292ce2ad7f9c8b6a4781e1cb71f5b18b74e3
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPRR1B SPRR2A SPRR2D SPRR2E	9.50e-05	197	54	4	b57d2e3413ef6dd1da56c45087926f2f3eab876c
ToppCell	Biopsy_Other_PF-Mesenchymal-Mesothelial_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	SLC7A4 SPRR2F PRR9 PWWP3B	9.69e-05	198	54	4	86736f01e61bf4961f060b24ee1f1f48340737dd
Drug	4-tert-octylphenol	SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G CDH2	5.51e-08	159	50	7	ctd:C105260
Disease	Paroxysmal atrial fibrillation	HSPG2 PITX2 MBD5 CREB5	1.22e-04	156	48	4	C0235480
Disease	familial atrial fibrillation	HSPG2 PITX2 MBD5 CREB5	1.22e-04	156	48	4	C3468561
Disease	Persistent atrial fibrillation	HSPG2 PITX2 MBD5 CREB5	1.22e-04	156	48	4	C2585653
Disease	Atrial Fibrillation	HSPG2 PITX2 MBD5 CREB5	1.35e-04	160	48	4	C0004238
Disease	phosphatidylcholine 34:4 measurement	DACH1 MBD5	1.69e-04	12	48	2	EFO_0010378
Disease	level of C-X-C motif chemokine 2 in blood serum	SPRR2E SPRR2F	1.69e-04	12	48	2	OBA_2041207
Disease	level of C-X-C motif chemokine 3 in blood serum	SPRR2E SPRR2F	2.68e-04	15	48	2	OBA_2041208
Disease	atrial fibrillation	HSPG2 PITX2 MBD5 JMJD1C CREB5	3.36e-04	371	48	5	EFO_0000275
Disease	Anophthalmia-microphthalmia syndrome	PITX2 DACH1	5.34e-04	21	48	2	cv:C5680330
Disease	cortical thickness change measurement, age at assessment	SORCS2 CREB5	6.41e-04	23	48	2	EFO_0008007, EFO_0021501
Disease	monocyte count	SPRR2E SPRR2F GON4L HBP1 MBD5 LPAR1 ABHD16A CREB5	1.20e-03	1320	48	8	EFO_0005091
Disease	ascending aortic diameter	MBD5 JMJD1C LPAR1	1.55e-03	140	48	3	EFO_0021787

Protein segments in the cluster

Peptide	Gene	Start	Entry
ATHCTPLPAQNFQMP	ABHD16A	541	O95870
CPFQAPNVSSMISNL	ADCY4	691	Q8NFM4
PCQLPFPSTMQQHSP	AMOTL1	376	Q8IY63
TVQAMQPPSQAPAQD	SLC7A4	616	O43246
NSCAQDPASFMPPQQ	ANKRD12	1476	Q6UB98
MPPQQPCSFPSQSLS	ANKRD12	1486	Q6UB98
PSPVENTPQNNECKM	DACH1	176	Q9UI36
QPCACPLTNPENMFS	HSPG2	1611	P98160
MQGPNLSNPCASPQV	CREB5	211	Q02930
QNAQPPMVTNTARTC	FIGNL1	186	Q6PIW4
ISLCMPESQQQNTPP	JMJD1C	1966	Q15652
EQITPQQPVMNCYQT	KIAA1109	1491	Q2LD37
SMSYQAPPQQLPSAQ	LENG8	151	Q96PV6
ISQPQFTAMNEPQCF	LPAR1	11	Q92633
MTCENQNPCFPIQLP	TPO	261	P07202
CQVMRSQPPQPQACQ	GLI2	1466	P10070
MCAVLSPPPQPSSNQ	KCNU1	796	A8MYU2
PQQQPPLSQCSMNNS	KAT6A	1696	Q92794
PLSQCSMNNSFTPAP	KAT6A	1701	Q92794
TCMVFQTQPVSSQPQ	AHSG	246	P02765
QQSMDPTAFPVPTFQ	DLGAP3	856	O95886
CNMIQPVNAAVAQSP	GON4L	1161	Q3T8J9
PQATQMNTPSQPRQH	EIF4G1	36	Q04637
QGQSTIPCPANNNPM	MBD5	996	Q9P267
SRCPSQPIMNPTVQQ	KIAA1210	911	Q9ULL0
NIATSPQSPLMQCSF	HBP1	116	O60381
MSCQQNQQQCQPPPS	LCE3C	1	Q5T5A8
SNNMPPICVQNTPKV	CFAP47	1721	Q6ZTR5
QAPSTPSPNMFTINN	CDH2	311	P19022
CPGLVNNPSMPTQTS	SLITRK6	566	Q9H5Y7
PSNPCLDTSQNQPSM	PWWP3B	286	Q5H9M0
QSPPFLFNEMSNVCP	SPATA31A6	441	Q5VVP1
QSPPFLFNEMSNVCP	SPATA31A7	441	Q8IWB4
MQQSQVQLQCPLTPP	SORCS2	766	Q96PQ0
NVNPLSSQSMFSPPN	PITX2	201	Q99697
NPNPGQSVSVVCPME	SNPH	391	O15079
QAFESQPAAPAVPMN	DZIP1	461	Q86YF9
MPLNATFPDSFQQPN	SMAD1	166	Q15797
QPSSPPNQCANVMAG	TET1	1301	Q8NFU7
QSPPFLFNEMSNVCP	SPATA31A3	441	Q5VYP0
NFSVSQVPNMPSCPQ	UBAP1	366	Q9NZ09
MVQAQVPNQTCPNTV	ZNF268	141	Q14587
QSPPFLFNEMSNVCP	SPATA31A1	441	Q5TZJ5
QSPPFLFNEMSNVCP	SPATA31A5	441	Q5VU36
PQTPPILSMNAFFNN	RWDD4	56	Q6NW29
MSSQQQKQPCTPPPQ	SPRR1B	1	P22528
MSYQQQQCKQPCQPP	SPRR2A	1	P35326
MSYQQQQCKQPCQPP	SPRR2B	1	P35325
MSYQQQQCKQPCQPP	SPRR2D	1	P22532
MSYQQQQCKQPCQPP	SPRR2E	1	P22531
MSYQQQQCKQPCQPP	SPRR2F	1	Q96RM1
MSYQQQQCKQPCQPP	SPRR2G	1	Q9BYE4
NVPPQSMTDQPQLAF	ZDBF2	1046	Q9HCK1
PVLDSNDPNFQMPCS	PHF3	66	Q92576
MSFSEQQCKQPCVPP	PRR9	1	Q5T870
NNSSVSPPQQMPYNV	ZNF347	216	Q96SE7
MCDQQKQPQFPPSCV	XP32	1	Q5T750
SVPNPNVICNSMFPV	ZNF638	251	Q14966