Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin filament binding	SYNE1 SPTA1 SPTBN2 ESPNL	4.02e-04	227	31	4	GO:0051015
GeneOntologyMolecularFunction	histone binding	TSPY4 TSPY9 CHD8 CDYL	7.20e-04	265	31	4	GO:0042393
GeneOntologyMolecularFunction	actin binding	FHL3 SYNE1 SPTA1 SPTBN2 ESPNL	7.89e-04	479	31	5	GO:0003779
GeneOntologyCellularComponent	spectrin-associated cytoskeleton	SPTA1 SPTBN2	7.61e-05	9	31	2	GO:0014731
GeneOntologyCellularComponent	spectrin	SPTA1 SPTBN2	7.61e-05	9	31	2	GO:0008091
Domain	Spectrin	SYNE1 SPTA1 SPTBN2	7.17e-06	23	31	3	PF00435
Domain	Spectrin_repeat	SYNE1 SPTA1 SPTBN2	1.47e-05	29	31	3	IPR002017
Domain	Spectrin/alpha-actinin	SYNE1 SPTA1 SPTBN2	1.99e-05	32	31	3	IPR018159
Domain	SPEC	SYNE1 SPTA1 SPTBN2	1.99e-05	32	31	3	SM00150
Domain	Actinin_actin-bd_CS	SYNE1 SPTBN2	6.60e-04	23	31	2	IPR001589
Domain	ACTININ_2	SYNE1 SPTBN2	6.60e-04	23	31	2	PS00020
Domain	ACTININ_1	SYNE1 SPTBN2	6.60e-04	23	31	2	PS00019
Domain	Chromo_domain	CHD8 CDYL	7.19e-04	24	31	2	IPR023780
Domain	Chromo	CHD8 CDYL	8.45e-04	26	31	2	PF00385
Domain	CHROMO_2	CHD8 CDYL	9.81e-04	28	31	2	PS50013
Domain	CHROMO_1	CHD8 CDYL	9.81e-04	28	31	2	PS00598
Domain	Chromodomain-like	CHD8 CDYL	1.28e-03	32	31	2	IPR016197
Domain	CHROMO	CHD8 CDYL	1.36e-03	33	31	2	SM00298
Domain	Chromo/shadow_dom	CHD8 CDYL	1.36e-03	33	31	2	IPR000953
Domain	CH	SYNE1 SPTBN2	5.20e-03	65	31	2	SM00033
Domain	CH	SYNE1 SPTBN2	6.00e-03	70	31	2	PF00307
Domain	-	SYNE1 SPTBN2	6.17e-03	71	31	2	1.10.418.10
Domain	CH	SYNE1 SPTBN2	6.51e-03	73	31	2	PS50021
Domain	CH-domain	SYNE1 SPTBN2	6.86e-03	75	31	2	IPR001715
Domain	EF-hand-dom_pair	PLCG2 NKD1 SPTA1	1.17e-02	287	31	3	IPR011992
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTA1 SPTBN2	1.24e-04	10	24	2	MM15112
Pubmed	Spectrin tethers and mesh in the biosynthetic pathway.	SPTA1 SPTBN2	8.20e-07	2	32	2	10852813
Pubmed	Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.	SPTA1 SPTBN2	4.92e-06	4	32	2	21412925
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	SPTA1 SPTBN2	3.67e-05	10	32	2	22159418
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTA1 SPTBN2	1.24e-04	18	32	2	12119179
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CUL9 URB2 ACOT11 SYNE1	5.13e-04	407	32	4	12693553
GeneFamily	EF-hand domain containing\|Spectrins	SPTA1 SPTBN2	1.74e-05	7	17	2	1113
GeneFamily	EF-hand domain containing	NKD1 SPTA1	1.76e-02	219	17	2	863
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF816 ZNF202 ZFP3	2.80e-02	718	17	3	28
Coexpression	GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_6H_UP	DNAAF2 URB2 CTPS1 ZFP3 ENDOG	3.56e-06	200	31	5	M4262
Coexpression	HOLLERN_SQUAMOUS_BREAST_TUMOR	SYT9 TGM1 NKD1 CTPS1	5.02e-05	173	31	4	M650
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NLRP10 FHL3 SYNE1 SPTA1	8.16e-06	180	32	4	ca2a35bfb67347e47f511589a3d0f763e6664634
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NLRP10 FHL3 SYNE1 SPTA1	8.16e-06	180	32	4	4e9e8cde2919610c4ac0025b1c9819808048bc1d
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NLRP10 FHL3 SYNE1 SPTA1	8.16e-06	180	32	4	466381bf93c3da6a2a241daadb68e9aad2964eae
Disease	response to angiotensin-converting enzyme inhibitor	SEPSECS ACOT11	2.86e-03	78	30	2	EFO_0005325

Protein segments in the cluster

Peptide	Gene	Start	Entry
RHEEAQFRFYRHVAE	URB2	381	Q14146
DRHHAYGRTDCFRVE	CHD8	1436	Q9HCK8
EDFHLDCRHERYPAR	GSG1L	286	Q6UXU4
CVEAYRQEAETHRRH	ACOT11	301	Q8WXI4
REAHAREAHAREAYT	AMER1	586	Q5JTC6
HHCVDENIERRNHYL	NKD1	246	Q969G9
DRHDDYFQERNREHE	CPSF7	446	Q8N684
AEYHGHRDCAQYLRE	ESPNL	311	Q6ZVH7
HEDQEFRCRSHVRDY	LNP1	71	A1A4G5
HHVDLQDYRCSRDSA	DNAAF2	261	Q9NVR5
HDYREVYREHVRCLE	NLRP10	96	Q86W26
HYRETHLRCAEFELR	PLCG2	616	P16885
FHLDRHLYFACRDDR	GLG1	306	Q92896
SRELFYEDRHFHEGC	FHL3	51	Q13643
NCEEYIHDFNRRHTE	CDYL	101	Q9Y232
YNERCTFHHQAREFA	CUL9	2296	Q8IWT3
EHDSCQDFIYHLRDR	SYT9	26	Q86SS6
QREEDLQRTRDYHDC	SYNE1	4231	Q8NF91
RECDFREDDSVHAYH	ENDOG	111	Q14249
ADYLEERHRHRFEVN	CTPS1	471	P17812
YHRHCYAEERQSAED	NKAPL	96	Q5M9Q1
DYEVEAYRRRHHNSS	TSPY9	246	A0A494C1R9
DYEVEAYRRRHHNSS	TSPY4	246	P0CV99
EALQRRHCAYEHDIQ	SPTBN2	1836	O15020
EHEGHYVCEVQDRRS	FLT4	646	P35916
SHYQCKEQRDAHRFE	RRAGB	276	Q5VZM2
DERHRQYEQCLDFHL	SPTA1	466	P02549
AYVRQGCEARRSHEH	SEPSECS	16	Q9HD40
RSDQNRREHHTDEYE	TGM1	121	P22735
ECGEDFSEHRRYLAH	ZNF202	541	O95125
ECDNVYIRRSHLERH	ZNF816	401	Q0VGE8
HQRIHTEERYHECNE	ZFP3	271	Q96NJ6