Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransporter activity

GABRB3 SLC5A7 SLC6A9 CACNA1E ATP10B MFSD8 ABCB10 P2RX6 NDUFS2 SLC25A48 SLC22A23

1.91e-0412894811GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

GABRB3 SLC5A7 SLC6A9 CACNA1E MFSD8 ABCB10 P2RX6 NDUFS2 SLC25A48 SLC22A23

4.17e-0411804810GO:0022857
GeneOntologyBiologicalProcesspositive regulation of tetrapyrrole biosynthetic process

SLC6A9 ABCB10

1.52e-053472GO:1901465
GeneOntologyBiologicalProcesspositive regulation of heme biosynthetic process

SLC6A9 ABCB10

1.52e-053472GO:0070455
GeneOntologyBiologicalProcesspositive regulation of tetrapyrrole metabolic process

SLC6A9 ABCB10

3.04e-054472GO:1901403
GeneOntologyBiologicalProcessmotor behavior

GABRB3 SPG11 MFSD8

6.90e-0535473GO:0061744
GeneOntologyBiologicalProcesspositive regulation of hemoglobin biosynthetic process

SLC6A9 ABCB10

7.58e-056472GO:0046985
GeneOntologyBiologicalProcessregulation of hemoglobin biosynthetic process

SLC6A9 ABCB10

1.41e-048472GO:0046984
GeneOntologyBiologicalProcesslytic vacuole organization

ATP10B MBTPS1 SPG11 MFSD8

1.55e-04119474GO:0080171
GeneOntologyBiologicalProcesslysosome organization

ATP10B MBTPS1 SPG11 MFSD8

1.55e-04119474GO:0007040
GeneOntologyBiologicalProcessregulation of tetrapyrrole biosynthetic process

SLC6A9 ABCB10

1.81e-049472GO:1901463
GeneOntologyBiologicalProcessregulation of heme biosynthetic process

SLC6A9 ABCB10

1.81e-049472GO:0070453
GeneOntologyBiologicalProcessregulation of tetrapyrrole metabolic process

SLC6A9 ABCB10

2.26e-0410472GO:1901401
GeneOntologyBiologicalProcessmembrane protein intracellular domain proteolysis

MBTPS1 SPPL2B

4.54e-0414472GO:0031293
GeneOntologyBiologicalProcesshemoglobin biosynthetic process

SLC6A9 ABCB10

5.98e-0416472GO:0042541
GeneOntologyCellularComponentlysosomal membrane

CD68 ATP10B SPG11 MFSD8 SPPL2B GPR137C

5.62e-04462476GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

CD68 ATP10B SPG11 MFSD8 SPPL2B GPR137C

5.62e-04462476GO:0098852
Pubmed

Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes.

SLC5A7 ACLY

5.19e-05848224763339
Pubmed

Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes.

KLHL30 SLC22A23

5.19e-05848218246200
Pubmed

N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.

MFSD8 EXOG SPPL2B BAHCC1

2.31e-0421748434048709
Pubmed

Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.

NELL1 SLC22A23

4.23e-042248219174780
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

LMAN1L ZNF622 SLC6A9 MBTPS1 SPG11 DOLPP1 NDUFS2 SLC22A23

4.26e-04132748832694731
Pubmed

Klf14 is an imprinted transcription factor that regulates placental growth.

NELL1 ERVW-1

4.63e-042348231675530
Pubmed

Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans.

GABRB3 NEB

5.93e-042648230121012
Pubmed

Genetic risk profiling and prediction of disease course in Crohn's disease patients.

NELL1 SLC22A23

6.89e-042848219422935
Pubmed

Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions.

SLC5A7 CD68

7.39e-042948224952082
Pubmed

Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.

ITLN1 SLC22A23

8.45e-043148221072187
Pubmed

Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation.

KREMEN1 KNOP1

1.34e-033948218346943
Pubmed

Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients.

ITLN1 SLC22A23

1.34e-033948219760754
GeneFamilySolute carriers

SLC5A7 SLC6A9 SLC25A48 SLC22A23

3.03e-03395284752
ToppCellfacs-Marrow-KLS-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A9 ABCB10 SPPL2B SLC22A23

2.79e-0516248414e9f8aaba308619eb9da90796c336e76cedac1f
ToppCelldroplet-Marrow-BM-30m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD68 CACNA1E SLC22A23 MINK1

2.79e-0516248475df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCellfacs-Marrow-KLS-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A9 ABCB10 SPPL2B SLC22A23

2.79e-05162484860ebf2390b4ad86475ad54717cbefcf61cd3b2a
ToppCellfacs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZP1 SPPL2B KLHL30 BAHCC1

3.36e-05170484d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCelldroplet-Kidney-nan-18m-Epithelial-collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP10B EXOG USP54 ARMCX4

3.85e-05176484533d544852038c0612aacf87f4b1c88ff7aace82
ToppCell(7)_DC_plasmacytoid|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

SEC61B CD68 NELL1 BAHCC1

4.48e-051834842c6475c935b5a90931be6b3c53f1f707cfcd11f4
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

GABRB3 LMAN1L CACNA1E NEB

4.98e-051884846d249fe92d51a19da19ec14bb2262d394255d577
ToppCellwk_08-11-Hematologic-Meg-ery-Definitive_erythroblast|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SLC6A9 ABCB10 ITLN1 SLC22A23

5.51e-05193484be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Macroglial-Astrocyte|GW23 / Sample Type, Dataset, Time_group, and Cell type.

SLC6A9 ZDHHC24 GAS2L2 SLC25A48

5.85e-0519648455a10faafcbe075eefdfcd7cff25ded040c23538
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Macroglial|GW23 / Sample Type, Dataset, Time_group, and Cell type.

SLC6A9 ZDHHC24 GAS2L2 SLC25A48

5.85e-051964848025ec8aee8455c7b0261aa4a0caacebd2f50634
Diseasepericalcarine cortex volume measurement

GABRB3 ABCB10

1.35e-0411472EFO_0010322
Diseasenicotine dependence

NELL1 SLC25A48 SLC22A23

2.65e-0478473EFO_0003768
Diseaseunipolar depression, alcohol dependence

NELL1 FOXB1 NEB

2.65e-0478473EFO_0003761, MONDO_0007079
Diseaselow affinity immunoglobulin gamma Fc region receptor II-b measurement

ITLN1 NDUFS2

7.28e-0425472EFO_0021970
Diseasesystemic juvenile idiopathic arthritis

SLC6A9 OR14A16

1.86e-0340472EFO_1001999
Diseasevitamin D measurement, COVID-19

DPP9 CYP2R1

2.78e-0349472EFO_0004631, MONDO_0100096
Diseaseresponse to beta blocker, heart rate

GABRB3 NELL1

3.75e-0357472EFO_0004326, EFO_0007766

Protein segments in the cluster

PeptideGeneStartEntry
GTDLGWYMAVGTHRG

MAMDC4

106

Q6UXC1
RSPSLWMGGHSYGLG

BAHCC1

826

Q9P281
GIRSQGGVSSGMWSA

CACNA1E

666

Q15878
MYAFWVGISIGGLSS

ABCB10

436

Q9NRK6
AGAGNMSSVSYWAGV

ARMCX4

1281

Q5H9R4
GGDSTDDGGYRSSMW

ATP10B

671

O94823
GVYMGWLTASGSGAR

MFSD8

451

Q8NHS3
LGDALYVTGGRWQGM

KLHL30

511

Q0D2K2
MYTTQGGGEAWGISV

CD68

181

P34810
YQTFCDMTSGGGGWT

ITLN1

66

Q8WWA0
DGMRGGAATGWYGAN

NKX2-4

126

Q9H2Z4
TWSQVLYGGIAGGLM

DOLPP1

161

Q86YN1
SSRGMTTWELPGGYG

MBTPS1

371

Q14703
GLGRRGAQGMAVWYT

LMAN1L

101

Q9HAT1
GAQGMAVWYTRGRGH

LMAN1L

106

Q9HAT1
GISGSMGPGSWYSEG

KRT32

76

Q14532
QSLGWYGTMTGCGSS

GPR137C

376

Q8N3F9
GKSTGWMTESSYGLR

GANC

786

Q8TET4
MGAGSHRVEGWTVYG

KREMEN1

381

Q96MU8
DRAMSWKYSRGAGLG

KNOP1

421

Q1ED39
MWGLAGGRLFGIFSA

GABRB3

1

P28472
YVGSGWSRGHMAPAG

EXOG

131

Q9Y2C4
YGVSRLSGSVWTMAG

NELL1

771

Q92832
YGFSGVMLRGSGIQW

NDUFS2

286

O75306
TMGSSLGTGWPHVYG

FOXB1

206

Q99853
LGTGWPHVYGSAGMI

FOXB1

211

Q99853
IHGWSYGGFLSLMGL

DPP9

726

Q86TI2
MGGLLNSRYGRGWVD

CYP2R1

121

Q6VVX0
VMVRVGGGWDTLGHY

GAS2L2

251

Q8NHY3
VRWSNSGMYLASGGD

HIRA

76

P54198
MGSPGATTGWGLLDY

P2RX6

11

O15547
GWTTVGDMEGCGHYR

MINK1

1106

Q8N4C8
SWLYGGLIAVMHTAG

OR14A16

146

Q8NHC5
FTMTATWVGGGYING

SLC5A7

56

Q9GZV3
WTYFTQTGMSDGGGV

ERVW-1

106

Q9UQF0
TTTGRGGDMGNWTSL

SLC22A23

141

A1A5C7
LAGGMAGAISWGTAT

SLC25A48

221

Q6ZT89
SGRTGWFGAFVVMIG

PMIS2

126

A0A1W2PS18
WTMVAGGGASVVYSD

ACLY

276

P53396
ASAGGSWGTAAMGRV

SPG11

11

Q96JI7
MAGGSATTWGYPVAL

ZP1

1

P60852
RTTSAGTGGMWRFYT

SEC61B

46

P60468
GTGGMWRFYTEDSPG

SEC61B

51

P60468
MAVGTVAIGGYWAGS

SPPL2B

181

Q8TCT7
SLGCAWGGLITMASY

SLC6A9

371

P48067
GVMLAGRGLGQGWAY

ZDHHC24

81

Q6UX98
GTLMGTAIGTCFGYW

YIPF3

181

Q9GZM5
YRALGWTGSTGAALM

ZNF622

426

Q969S3
GRWPGYLNGGRMESS

ZNF662

136

Q6ZS27
MSWKRNYFSGGRGSV

USP54

1

Q70EL1
GWMYGTVQRTGRTGM

NEB

6646

P20929