Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentpericentriolar material

PCM1 CEP192

2.05e-0428162GO:0000242
GeneOntologyCellularComponentcentriole

CEP162 PCM1 CEP192

2.83e-04172163GO:0005814
DomainPept_cys_AS

DNAH8 CAPN14

2.25e-0428152IPR000169
DomainEF_HAND_2

CACNA1E CAPN14 SPTA1

7.61e-04231153PS50222
DomainEF_hand_dom

CACNA1E CAPN14 SPTA1

7.71e-04232153IPR002048
DomainChannel_four-helix_dom

KCND2 CACNA1E

9.37e-0457152IPR027359
Domain-

KCND2 CACNA1E

9.37e-04571521.20.120.350
DomainIon_trans_dom

KCND2 CACNA1E

3.68e-03114152IPR005821
DomainIon_trans

KCND2 CACNA1E

3.68e-03114152PF00520
PathwayREACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE

CEP162 PCM1 CEP192

1.06e-0496143MM15207
PathwayREACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE

CEP162 PCM1 CEP192

1.09e-0497143M27478
Pubmed

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.

BRCA2 SNX2 CEP192

9.07e-074216329348145
Pubmed

Genetic mapping of the gene encoding the alpha1 subunit of neuronal calcium channels.

CACNA1E PTPRC

1.98e-0651628661716
Pubmed

Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction.

PCM1 PTPRC

5.55e-06816229946151
Pubmed

Receptors for Fc epsilon and Fc gamma are linked on mouse chromosome 1.

SPTA1 PTPRC

7.13e-0691622971731
Pubmed

Genetic analysis of autoimmune gld mice. I. Identification of a restriction fragment length polymorphism closely linked to the gld mutation within a conserved linkage group.

SPTA1 PTPRC

7.13e-0691622894402
Pubmed

Mapping of alpha-spectrin on distal mouse chromosome 1.

SPTA1 PTPRC

7.13e-0691622885153
Pubmed

A molecular genetic approach to gld "autoimmune" disease.

SPTA1 PTPRC

8.91e-06101623416634
Pubmed

Establishment of a molecular genetic map of distal mouse chromosome 1: further definition of a conserved linkage group syntenic with human chromosome 1q.

SPTA1 PTPRC

8.91e-06101623384439
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

BRCA2 CEP162 SNX2 PCM1 CEP192

3.06e-0585316528718761
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

EPB41L5 CEP162 SNX2 PCM1 CEP192

3.20e-0586116536931259
Pubmed

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.

CEP162 PCM1 CEP192

3.90e-0514616321399614
Pubmed

PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates.

KCND2 PCM1

4.15e-052116239304345
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

CEP162 SPTA1 CEP192

5.92e-0516816330631154
Pubmed

Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1.

SPTA1 PTPRC

6.92e-05271622574151
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

SNX2 PCM1 CEP192

1.13e-0420916336779422
Pubmed

Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.

PCM1 CEP192

1.38e-043816236674791
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

EPB41L5 SF3B2 PCM1 GNL3L

2.91e-0473316434672954
Pubmed

The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.

PCM1 CEP192

3.01e-045616211076968
Pubmed

The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.

PCM1 CEP192

3.12e-045716216462731
Pubmed

Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.

PCM1 CEP192

3.23e-045816212852856
Pubmed

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

PCM1 CEP192

3.57e-04611627790358
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SF3B2 SNX2 PCM1 PTPRC

3.58e-0477416415302935
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

EPB41L5 CEP162 PCM1 CEP192

3.63e-0477716435844135
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

EPB41L5 SF3B2 SNX2 PCM1 CEP192

4.17e-04148716533957083
Pubmed

Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.

PCM1 CEP192

4.18e-046616212221128
Pubmed

The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.

SF3B2 PCM1 CEP192

4.33e-0433016332529326
InteractionCEP131 interactions

BRCA2 CEP162 PCM1 CEP192

1.56e-05200164int:CEP131
InteractionCETN1 interactions

SF3B2 PCM1 CEP192

1.58e-0563163int:CETN1
InteractionCEP295 interactions

PCM1 CEP192 GNL3L

2.27e-0571163int:CEP295
InteractionZNF830 interactions

SF3B2 PCM1 GNL3L

2.79e-0576163int:ZNF830
InteractionSPATA2 interactions

SNX2 PCM1 CEP192

4.18e-0587163int:SPATA2
InteractionCEP135 interactions

BRCA2 CEP162 PCM1 CEP192

5.20e-05272164int:CEP135
InteractionKRT19 interactions

CEP162 SNX2 PCM1 CEP192

5.98e-05282164int:KRT19
InteractionCEP120 interactions

CEP162 PCM1 CEP192

7.54e-05106163int:CEP120
InteractionWRAP73 interactions

EPB41L5 CEP162 PCM1

1.17e-04123163int:WRAP73
InteractionCCDC14 interactions

CEP162 PCM1 CEP192

1.35e-04129163int:CCDC14
InteractionYWHAQ interactions

EPB41L5 CEP162 SNX2 SPTA1 PCM1 CEP192

1.42e-041118166int:YWHAQ
InteractionNIN interactions

BRCA2 CEP162 PCM1 CEP192

1.52e-04359164int:NIN
InteractionSNX32 interactions

BRCA2 SNX2

1.75e-0425162int:SNX32
InteractionTTF2 interactions

BRCA2 CEP162 PCM1

1.99e-04147163int:TTF2
InteractionCEP89 interactions

CEP162 PCM1 CEP192

1.99e-04147163int:CEP89
InteractionKIZ interactions

PCM1 CEP192

2.05e-0427162int:KIZ
InteractionXRCC2 interactions

BRCA2 SPTA1

2.37e-0429162int:XRCC2
InteractionSASS6 interactions

CEP162 PCM1 CEP192

2.50e-04159163int:SASS6
InteractionKRT18 interactions

CEP162 SF3B2 SNX2 CEP192

2.75e-04419164int:KRT18
InteractionCCDC66 interactions

CEP162 PCM1

2.89e-0432162int:CCDC66
InteractionCEP20 interactions

CEP162 PCM1

3.08e-0433162int:CEP20
InteractionFBF1 interactions

CEP162 PCM1 CEP192

3.10e-04171163int:FBF1
InteractionC2CD3 interactions

CEP162 PCM1

3.27e-0434162int:C2CD3
InteractionCTTN interactions

BRCA2 ARPC5L SF3B2 SNX2

3.61e-04450164int:CTTN
InteractionNINL interactions

BRCA2 CEP162 PCM1 CEP192

3.86e-04458164int:NINL
InteractionERC1 interactions

CEP162 SNX2 PCM1

4.03e-04187163int:ERC1
InteractionCEP192 interactions

PCM1 CEP192 GNL3L

4.35e-04192163int:CEP192
InteractionCNTRL interactions

CEP162 PCM1 CEP192

4.42e-04193163int:CNTRL
InteractionKIAA1671 interactions

CEP162 PCM1 CEP192

4.48e-04194163int:KIAA1671
InteractionHOOK3 interactions

SNX2 PCM1 CEP192

5.05e-04202163int:HOOK3
InteractionFBXL13 interactions

BRCA2 SNX2

5.48e-0444162int:FBXL13
InteractionBBS4 interactions

CEP162 PCM1

6.26e-0447162int:BBS4
InteractionCASK interactions

EPB41L5 SF3B2 PCM1

6.56e-04221163int:CASK
InteractionNEDD1 interactions

CEP162 PCM1 CEP192

6.56e-04221163int:NEDD1
InteractionERCC6 interactions

BRCA2 SF3B2 SPTA1

6.82e-04224163int:ERCC6
InteractionRPGRIP1L interactions

CEP162 PCM1 CEP192

6.91e-04225163int:RPGRIP1L
InteractionDUSP16 interactions

BRCA2 PCM1 CEP192

8.03e-04237163int:DUSP16
InteractionPCNT interactions

CEP162 PCM1 CEP192

8.43e-04241163int:PCNT
InteractionCCNB1 interactions

BRCA2 CEP162 PCM1

8.74e-04244163int:CCNB1
InteractionTBC1D31 interactions

CEP162 PCM1

8.88e-0456162int:TBC1D31
InteractionSPATA24 interactions

CEP162 PCM1

1.02e-0360162int:SPATA24
InteractionCARD8 interactions

BRCA2 CEP192

1.02e-0360162int:CARD8
InteractionERCC5 interactions

BRCA2 SPTA1

1.02e-0360162int:ERCC5
GeneFamilyEF-hand domain containing

CACNA1E CAPN14 SPTA1

2.69e-04219113863
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1E ARPC5L PTPRC

2.05e-05152163b750302d442160a1007659c2386ac90282bf95d2
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BRCA2 ARPC5L SNX2

2.26e-051571636730b775308f45a2f3946016bdbb7f8e5b5efe49
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC5L SNX2 PTPRC

2.96e-051721633784fd1e833703519889942e39fda991f03c3c76
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC5L SNX2 PTPRC

2.96e-05172163995139aa38f8b9ff23166128b15476cd8a3ff1b8
ToppCellControl-B_cells-B_cells|Control / group, cell type (main and fine annotations)

DNAH8 SNX2 PTPRC

3.17e-05176163d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC5L SNX2 PTPRC

3.23e-05177163c506b8fd9a550e6cf93b64a1f7eed2543224a140
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC5L SNX2 PTPRC

3.23e-05177163840eaac045ada42cae0ab81177d1d0ae55a65633
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC5L SNX2 PTPRC

3.28e-051781638d74c12c4b0ce8bcb0f59151bdc67036997095ef
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC5L SNX2 PTPRC

3.28e-051781638ef229f38aa8a2ae8b366c3ce26d4cb1302d674a
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC5L SNX2 PTPRC

3.28e-05178163525c4b3f9736ff206e2f1378c2a29ba4f13ba22f
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BRCA2 CACNA1E PCM1

3.34e-05179163d15182c668d7c37be8214cad9f1fe35d1409c9a1
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BRCA2 CACNA1E PCM1

3.34e-05179163e22a275a7c0ed19113c833a75d6c49fcc19aa13a
ToppCellfacs-Lung-EPCAM-18m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARPC5L SNX2 PTPRC

3.45e-051811632c2b812cdd350271935d7007665c26093756ebee
ToppCellfacs-Lung-EPCAM-18m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARPC5L SNX2 PTPRC

3.45e-05181163ce30724788d9b5c6dfa4f9f8d318c3d2565165ed
ToppCellB_cells-ISG-high_B_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

BRCA2 DNAH8 SNX2

3.57e-05183163dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCellCOVID-19_Severe-B_memory|World / disease group, cell group and cell class

CACNA1E DNAH8 SNX2

3.80e-05187163f29c71f2505bb64f3010ada491d422b87a6f7db3
ToppCellfacs-Marrow-B-cells|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E ARPC5L SNX2

4.05e-05191163f84cd55e6fb112d271d35db11ad7648e03186e46
ToppCellCOVID-19-kidney-Proliferating_T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

BRCA2 SPTA1 PTPRC

4.05e-05191163bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCellCOVID-19-kidney-Proliferating_T_cell|kidney / Disease (COVID-19 only), tissue and cell type

BRCA2 SPTA1 PTPRC

4.31e-051951637e05e56f8d0a7a052830c7db12b10dace7d10760
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ARPC5L PCM1 PTPRC

4.44e-051971632e9677b4b9a7c88db16416e5f114a2031ec3bc24
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ARPC5L PCM1 PTPRC

4.44e-051971634c9919914079e76b1d2220b249e0d0b0d9bf4bc0
ToppCellsevere|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ARPC5L SF3B2 PTPRC

4.64e-05200163accc618d6b960bff30cb531c1226295bfc8650f6
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-Like-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BRCA2 DNAH8

6.10e-04103162eb9f008b5fb8a01df8ea4faf6e6aebc1a9db9bd3
ToppCellsevere-unassigned|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BRCA2 CACNA1E

9.39e-04128162bef9cf0078fa8498d63f0723f1fa4a3c92405e10
ToppCellP07-Hematopoietic|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SPTA1 PTPRC

1.09e-03138162fb8038393c2b88eb29bd23574c0c6178644900be
ToppCellLymphoid-B_cells|World / shred on cell class and cell subclass (v4)

SNX2 PTPRC

1.23e-03147162aa4486200c523f2c9d3bad7a14f1764c2d92076b
ToppCellCOVID-19-kidney-Technical/muscle|kidney / Disease (COVID-19 only), tissue and cell type

KCND2 DNAH8

1.25e-031481620dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

BRCA2 CEP162

1.27e-0314916254c9c6282f5f5de43dfaf2972fab3e3dcf9838a3
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

BRCA2 CEP162

1.27e-0314916214d2e8cab97108d8fa94e540c1957b73ed32dc73
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A2|356C / Donor, Lineage, Cell class and subclass (all cells)

SPTA1 CEP192

1.28e-031501626bdf9df586f348641a25a445e83a41e47e7f347e
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_large-bowel / Manually curated celltypes from each tissue

EPB41L5 PTPRC

1.32e-0315216295944864ce7539ff8de028f5700694931338f3ff
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CACNA1E CEP192

1.32e-031521620652ee3443e6fbb679d2c4f326239ae7c803f924
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_memory_T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

EPB41L5 PTPRC

1.34e-0315316264d0f37d7af9b76234f683379e3689771f71fe70
ToppCellIIH-Treg|IIH / Condition, Cell_class and T cell subcluster

BRCA2 DNAH8

1.34e-0315316217704e18833812fcf2a2727b1e3f8a9984ba5b59
ToppCellIIH-Treg-CD4_Treg|IIH / Condition, Cell_class and T cell subcluster

BRCA2 DNAH8

1.35e-03154162d2211a892654b92decb208969040920f7ae8ba1e
ToppCellMonocytes-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

GNL3L PTPRC

1.37e-0315516282abfcee23ba08a1eb4208d367393285026e5388
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|367C / Donor, Lineage, Cell class and subclass (all cells)

DNAH8 PTPRC

1.41e-03157162f1c6c313836352271033d23efd31b0f0a8a09e02
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Myeloid-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCND2 PTPRC

1.41e-03157162c8f516d3f5622202d3f8514f68614cd86ea3f667
ToppCellE15.5-Hematopoietic|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SPTA1 PTPRC

1.41e-031571626315aef4b9bf673069d43a730d4e940011509ac1
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Myeloid|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCND2 PTPRC

1.41e-031571624862a11ab8df27d26b4f1c1785e544a2d5b6db6e
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Myeloid-macrophage|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCND2 PTPRC

1.41e-03157162a0ec1628ce29841889f1d9d4ee9422921af7b0b5
ToppCellfacs-Trachea-nan-3m-Myeloid-lymphocyte_of_B_lineage|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH8 CEP162

1.41e-031571620fecc14959c4c9efc19d5c06475a890e0a30f148
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SPTA1 PTPRC

1.42e-03158162f61ebe3a316e4259387cd9da83707f15e6473cae
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BRCA2 PTPRC

1.44e-03159162e9c51e611ebd427bbe51e3e036c14122c36ea372
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

KCND2 DNAH8

1.44e-031591625335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCelldroplet-Liver-LIVER_NPC-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E PTPRC

1.44e-03159162997963d879e5819683793cddf5e1acff1b81a1b8
ToppCelldroplet-Liver-LIVER_NPC|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E PTPRC

1.44e-03159162e4eaa88772835d6b78e1a18a0cec52de51e80339
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Lymphocytic-B_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E PTPRC

1.46e-031601626bafbe2b4b98bc088406a516d079093f89d9c344
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E PTPRC

1.46e-03160162e9e52532131cdc3fb01e81cfc046e3f670cc8e75
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SNX2 PTPRC

1.46e-0316016218954241e11309ecb0f3ca87897eadcb20dc8eca
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

BRCA2 SPTA1

1.48e-031611628ec923c230a7a3cce5edf2a736b3a00d607c698a
ToppCelldroplet-Fat-Scat-21m-Lymphocytic-B_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRCA2 CACNA1E

1.48e-03161162e52735f955f0a53da5cbe5a2d77a00484e5109b3
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH8 PTPRC

1.50e-0316216258fe827198c172eeaa26273b0fad7991a718b0bf
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|367C / Donor, Lineage, Cell class and subclass (all cells)

ARPC5L PTPRC

1.53e-031641624a834a7908d8aa643a2096c52430dad795898474
ToppCellfacs-Heart-RA-24m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E PTPRC

1.55e-03165162995f1524965a4314938f27165166f0aaff9dea02
ToppCellILEUM-non-inflamed-(1)_Cytotoxic_T_cells|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ARPC5L PTPRC

1.57e-0316616267f9d88329724cdda11bf76e964f66456ff6fb46
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH8 PTPRC

1.57e-03166162a41a20cef053c67da2d435e3e132ce28f1661c03
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCND2 CACNA1E

1.59e-03167162e1b1a952fce27ab9cf16919b290625ff4a75261e
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PCM1 PTPRC

1.61e-03168162b94b1f37c92e019d01ecfa3b7cc6797b6e4a56ff
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC5L PTPRC

1.61e-03168162943687a33fffd7e19d906b9dd385a126bcea109a
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-CD45____T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH8 PTPRC

1.63e-031691623c4c3279cd72f39b5e7ff77741950ed3873c0317
ToppCellfacs-Lung-Endomucin-3m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPB41L5 THUMPD2

1.63e-031691622d23b4cee060f8adddc430c1c10d4e25205b4af6
ToppCellControl-T_cells-Tregs|Control / group, cell type (main and fine annotations)

DNAH8 PTPRC

1.63e-03169162e1e0983f31ec81b3fad5f9c6140d17f03f81a5dc
ToppCellfacs-Heart-RA-24m-Lymphocytic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E PTPRC

1.63e-03169162dcf92121fb00e3b6498e2648363e90ac044ea396
ToppCelldroplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E SPTA1

1.63e-03169162c5015ddb838849ea892a2cae5a739b554eb6d793
ToppCellfacs-Lung-Endomucin-3m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPB41L5 THUMPD2

1.63e-03169162ecaf08e8e0b54d1c97a02bc1f65409fd43d68227
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH8 PTPRC

1.63e-03169162d6437afa298c280d202ba686338c6d8a37bd7ab7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BRCA2 PTPRC

1.63e-0316916254b13ab02b4c187f4754045ecfcf409749e7ccc0
ToppCellfacs-Lung-Endomucin-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPB41L5 THUMPD2

1.63e-03169162ad6af6609acf158cb79e45ee7ca9af332be3c40c
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SNX2 PTPRC

1.64e-031701626ec0cf055ae55e9fac147f7989c47f83ab07270c
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC5L PTPRC

1.66e-03171162656a9f407461dbf5c9c0bd234399e1fef6abce2a
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E GNL3L

1.66e-03171162d1e87478d8c0329e662849823f5c7604f20e1b1a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BRCA2 PTPRC

1.66e-0317116255c7bf7211587fa08df13c0a4ff5b78a85d5439e
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

PCM1 PTPRC

1.66e-031711622e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T4_reg-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PCM1 PTPRC

1.68e-031721629497948bbe53fb88c6ff6b347f743d456da587e5
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SNX2 PTPRC

1.68e-03172162c96bd3407911df3e3e6d7a3dba786b11814b9598
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SNX2 PTPRC

1.68e-03172162714172f31abd0d25261df6115ec6a9df491fa14b
ToppCellLPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT-iNKT-MAIT|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARPC5L PTPRC

1.70e-03173162fde1fabb8d13d05998ac3f21ecb1fde6a7a2f337
ToppCellLPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARPC5L PTPRC

1.70e-03173162dcde3252ff96448d3a61039a4948c74ad321a218
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC5L SNX2

1.72e-0317416226ca6ebaa0081108d44c01f8ca56a63724f1c99d
ToppCellLPS-antiTNF-Lymphocytic_NKT-iNKT/MAIT|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARPC5L PTPRC

1.72e-0317416261aa89b56ebda0eba1ba675d5f036992967f670f
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SNX2 PTPRC

1.72e-031741620a8fa44604be19fbac722ebc6d1cd72b71be7022
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BRCA2 PTPRC

1.72e-031741627b318796728001c17b4043d2b033330c7be40c78
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THUMPD2 PTPRC

1.72e-03174162723848d2f8ae9cf4f15d4b4a130f9a64dab443c7
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC5L SNX2

1.72e-031741627c8704766dd4c80250754b5ee9907b342b9c2623
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARPC5L SNX2

1.72e-031741629aa2168d3bcef7cdc5a47442618cb8e9eb24c95b
ToppCell3'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CEP192 PTPRC

1.74e-03175162cd42020fe57afeaadfbd3ef6d7375e66d71e9669
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRCA2 CEP162

1.74e-0317516231f0fb2e47e357dbf9c15436b7df85b3c370ded7
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCND2 CACNA1E

1.74e-0317516259249c9e83952d7277010e7be3c779e26399eb5d
ToppCellLPS-antiTNF-Lymphocytic_NKT-iNKT/MAIT-iNKT-MAIT|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARPC5L PTPRC

1.74e-0317516298cb577df466700e72d1bbc6689205ccf2e7fcba
ToppCellChildren_(3_yrs)-Immune-enucleated_erythrocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

KCND2 THUMPD2

1.74e-0317516236cb3c8116bd467ee5da0630d8b3d3e4afcc2ded
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BRCA2 PTPRC

1.74e-03175162f7d191cde68de8f3457fa62b1df53b6d0dbe5001
ToppCelldroplet-Heart-HEART-1m-Hematologic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX2 PTPRC

1.74e-0317516243b9cfd7c47d57244565c641e57f3256b5900804
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCND2 CACNA1E

1.74e-03175162b35cc1357495f2a03a6500f807c6e6f8c877734d
ToppCellfacs-Lung-Endomucin-3m-Lymphocytic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX2 PTPRC

1.76e-031761629b58734017ceabe81f490dd0b9f3192bc903d455
ToppCelldroplet-Heart-HEART-1m-Hematologic-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX2 PTPRC

1.76e-031761621df640f88667e2dad30e65279d6d33bba75024c1
ToppCellwk_15-18-Hematologic_Lymphocytic-NK-Activated_NK|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ARPC5L PTPRC

1.76e-031761626802ed40eb0f91674d4f0120a3d4888c8a2e9612
ToppCellfacs-GAT-Fat-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH8 PTPRC

1.76e-03176162acd05ca8952710feedbfe377b1330f3c2406d044
ToppCelldroplet-Kidney-nan-21m-Lymphocytic-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH8 PTPRC

1.76e-03176162feafc757e7aa4f17128ff34886beb2fd3461c9ea
ToppCellCV-Severe-7|CV / Virus stimulation, Condition and Cluster

PCM1 PTPRC

1.76e-031761623de0c7d77210049e5616db21eed1490a17a5ec2d
Drugbutamben

KCND2 CACNA1E

4.84e-0515162CID000002482
DrugAC1L1BVU

BRCA2 CACNA1E

1.73e-0428162CID000001631
DrugRolitetracycline [751-97-3]; Down 200; 7.6uM; MCF7; HT_HG-U133A

EPB41L5 PCM1 GNL3L

2.73e-041851633369_DN
Drug5252917; Up 200; 14uM; MCF7; HT_HG-U133A_EA

EPB41L5 CEP162 PCM1

2.73e-04185163944_UP
DrugGanciclovir [82410-32-0]; Down 200; 15.6uM; MCF7; HT_HG-U133A

EPB41L5 PCM1 GNL3L

2.82e-041871633368_DN
DrugCarbarsone [121-59-5]; Down 200; 15.4uM; MCF7; HT_HG-U133A

CEP162 PCM1 GNL3L

3.05e-041921634110_DN
DrugAG-013608 [351320-38-2]; Down 200; 10uM; MCF7; HT_HG-U133A

EPB41L5 CEP162 PCM1

3.05e-041921636435_DN
DrugCarcinine [56897-53-1]; Down 200; 22uM; MCF7; HT_HG-U133A

EPB41L5 PCM1 GNL3L

3.10e-041931633242_DN
DrugFluticasone propionate [80474-14-2]; Down 200; 8uM; MCF7; HT_HG-U133A

EPB41L5 CEP162 PCM1

3.10e-041931634129_DN
DrugCephalosporanic acid, 7-amino [957-68-6]; Down 200; 14.6uM; MCF7; HT_HG-U133A

EPB41L5 PCM1 GNL3L

3.10e-041931633258_DN
DrugAcenocoumarol [152-72-7]; Down 200; 11.4uM; MCF7; HT_HG-U133A

EPB41L5 CEP162 GNL3L

3.10e-041931637232_DN
DrugMelatonin [73-31-4]; Down 200; 17.2uM; MCF7; HT_HG-U133A

CEP162 PCM1 GNL3L

3.10e-041931633293_DN
DrugPivampicillin [33817-20-8]; Down 200; 8.6uM; MCF7; HT_HG-U133A

EPB41L5 CEP162 PCM1

3.14e-041941633506_DN
DrugSyrosingopine [84-36-6]; Down 200; 6uM; MCF7; HT_HG-U133A

EPB41L5 PCM1 GNL3L

3.14e-041941632753_DN
DrugMethylhydantoin-5-(L) [40856-73-3]; Down 200; 35uM; MCF7; HT_HG-U133A

EPB41L5 CEP162 PCM1

3.24e-041961635679_DN
DrugPenbutolol sulfate [38363-32-5]; Down 200; 5.8uM; MCF7; HT_HG-U133A

CEP162 PCM1 GNL3L

3.24e-041961633534_DN
DrugMethylhydantoin-5-(D) [55147-68-7]; Down 200; 35uM; MCF7; HT_HG-U133A

CEP162 PCM1 GNL3L

3.24e-041961633333_DN
DrugGuanadrel sulfate [22195-34-2]; Up 200; 7.6uM; MCF7; HT_HG-U133A

CEP162 PCM1 GNL3L

3.24e-041961634720_UP
DrugCyclobenzaprine hydrochloride [6202-23-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A

EPB41L5 PCM1 GNL3L

3.24e-041961633268_DN
DrugApramycin [37321-09-8]; Up 200; 7.4uM; PC3; HT_HG-U133A

EPB41L5 KCND2 PCM1

3.29e-041971636614_UP
DrugTocopherol (R,S) [10191-41-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A

CEP162 PCM1 GNL3L

3.29e-041971633256_DN
DrugMerbromin [129-16-8]; Down 200; 5uM; MCF7; HT_HG-U133A

EPB41L5 CEP162 GNL3L

3.29e-041971633439_DN
DrugFuraltadone hydrochloride [3759-92-0]; Down 200; 11uM; MCF7; HT_HG-U133A

BRCA2 EPB41L5 GNL3L

3.34e-041981633413_DN
DrugPepstatin A [26305-03-3]; Down 200; 5.8uM; MCF7; HT_HG-U133A

CEP162 PCM1 GNL3L

3.34e-041981633264_DN
DrugPentylenetetrazole [54-95-5]; Up 200; 29uM; MCF7; HT_HG-U133A

BRCA2 SPTA1 GNL3L

3.34e-041981632255_UP
DrugMesoridazine besylate [32672-69-8]; Up 200; 7.4uM; PC3; HT_HG-U133A

BRCA2 CEP162 PCM1

3.34e-041981637256_UP
DrugLactobionic acid [96-82-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A

CEP162 PCM1 GNL3L

3.34e-041981633246_DN
DrugRauwolscine hydrochloride [6211-32-1]; Down 200; 10.2uM; MCF7; HT_HG-U133A

CEP162 PCM1 GNL3L

3.39e-041991632778_DN
DrugGriseofulvin [126-07-8]; Down 200; 11.2uM; MCF7; HT_HG-U133A

BRCA2 CEP162 PCM1

3.39e-041991634687_DN
Diseasebreast carcinoma

BRCA2 CEP162 PCM1 CEP192

1.85e-031019164EFO_0000305
Diseaseheel bone mineral density, urate measurement

SPTA1 PCM1

4.29e-03182162EFO_0004531, EFO_0009270
Diseaseplatelet component distribution width

CAPN14 SPTA1 PTPRC

7.29e-03755163EFO_0007984

Protein segments in the cluster

PeptideGeneStartEntry
EQEEEEAFNQKHALQ

CACNA1E

716

Q15878
EIEDQNERQDEFFTK

CAPN14

511

A8MX76
DEFDENKFVDEQEEA

ARPC5L

16

Q9BPX5
VDEHPEDAEFEQKIN

PCM1

646

Q15154
ANIVNEFDTHDKEDE

DNAH8

816

Q96JB1
EKTTNHEFVDEQVFE

KCND2

486

Q9NZV8
VEDDDQGKEQEHTFV

EPB41L5

286

Q9HCM4
FTKIQEEFEEHEENT

BRCA2

2866

P51587
KDDEDFQSIEFQVEQ

CEP162

1066

Q5TB80
DLIAQDEEEFNKEHQ

CEP192

516

Q8TEP8
DEEEFNKEHQFIQEE

CEP192

521

Q8TEP8
EEKIDQLHQEQAFAD

SNX2

371

O60749
QEEFEHKEEVLQELN

GNL3L

96

Q9NVN8
EHVREQQAQVEKEDF

SF3B2

846

Q13435
EEEFQNDIEKAIDTH

THUMPD2

186

Q9BTF0
QKHEDFEEAFTAQEE

SPTA1

516

P02549
HQEDKIEFDNEVDKV

PTPRC

1241

P08575