Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF75D ZNF677 ZNF397 ZNF85 ZNF562 ZNF493 ZSCAN21 ZIM3 ZNF175 ZNF681 ZNF260 ZNF256	7.07e-07	1244	35	12	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF75D ZNF677 ZNF397 ZNF85 ZNF562 ZNF493 ZSCAN21 ZIM3 ZNF175 ZNF681 ZNF260 ZNF256	8.89e-07	1271	35	12	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF75D ZNF677 ZNF397 ZNF85 ZNF562 ZNF493 ZSCAN21 ZIM3 ZNF175 ZNF681 ZNF260 ZNF256	2.70e-06	1412	35	12	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF75D ZNF677 ZNF397 ZNF85 ZNF562 ZNF493 ZSCAN21 ZIM3 ZNF175 ZNF681 ZNF260 ZNF256	3.79e-06	1459	35	12	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF85 ZNF493 ZNF175 ZNF681	2.29e-03	320	35	4	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF85 ZNF493 ZNF175 ZNF681	2.45e-03	326	35	4	GO:0001217
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF85 ZNF493 ZSCAN21 ZNF175 ZNF681	2.76e-03	560	35	5	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF85 ZNF493 ZSCAN21 ZNF175 ZNF681	2.89e-03	566	35	5	GO:0001216
Domain	Znf_C2H2-like	ZNF75D ZNF677 ZNF397 ZMAT4 ZNF85 ZNF562 ZNF493 ZSCAN21 ZIM3 ZNF175 ZNF681 ZNF260 ZNF256	8.59e-10	796	35	13	IPR015880
Domain	Znf_C2H2	ZNF75D ZNF677 ZNF397 ZMAT4 ZNF85 ZNF562 ZNF493 ZSCAN21 ZIM3 ZNF175 ZNF681 ZNF260 ZNF256	9.85e-10	805	35	13	IPR007087
Domain	ZnF_C2H2	ZNF75D ZNF677 ZNF397 ZMAT4 ZNF85 ZNF562 ZNF493 ZSCAN21 ZIM3 ZNF175 ZNF681 ZNF260 ZNF256	1.03e-09	808	35	13	SM00355
Domain	-	ZNF75D ZNF677 ZNF397 ZNF85 ZNF562 ZNF493 ZSCAN21 ZIM3 ZNF175 ZNF681 ZNF260 ZNF256	1.87e-09	679	35	12	3.30.160.60
Domain	zf-C2H2	ZNF75D ZNF677 ZNF397 ZNF85 ZNF562 ZNF493 ZSCAN21 ZIM3 ZNF175 ZNF681 ZNF260 ZNF256	2.36e-09	693	35	12	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF75D ZNF677 ZNF397 ZNF85 ZNF562 ZNF493 ZSCAN21 ZIM3 ZNF175 ZNF681 ZNF260 ZNF256	2.40e-09	694	35	12	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF75D ZNF677 ZNF397 ZNF85 ZNF562 ZNF493 ZSCAN21 ZIM3 ZNF175 ZNF681 ZNF260 ZNF256	8.29e-09	775	35	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF75D ZNF677 ZNF397 ZNF85 ZNF562 ZNF493 ZSCAN21 ZIM3 ZNF175 ZNF681 ZNF260 ZNF256	8.53e-09	777	35	12	PS00028
Domain	KRAB	ZNF75D ZNF677 ZNF85 ZNF562 ZNF738 ZIM3 ZNF175 ZNF681 ZNF256	1.44e-08	358	35	9	PS50805
Domain	KRAB	ZNF75D ZNF677 ZNF85 ZNF562 ZNF738 ZIM3 ZNF175 ZNF681 ZNF256	1.44e-08	358	35	9	PF01352
Domain	KRAB	ZNF75D ZNF677 ZNF85 ZNF562 ZNF738 ZIM3 ZNF175 ZNF681 ZNF256	1.87e-08	369	35	9	SM00349
Domain	KRAB	ZNF75D ZNF677 ZNF85 ZNF562 ZNF738 ZIM3 ZNF175 ZNF681 ZNF256	1.91e-08	370	35	9	IPR001909
Domain	zf-C2H2_6	ZNF677 ZNF85 ZNF562 ZNF493 ZIM3 ZNF681 ZNF260 ZNF256	9.26e-08	314	35	8	PF13912
Domain	-	TMEM131 HYDIN	9.49e-05	8	35	2	2.60.40.360
Domain	PapD-like	TMEM131 HYDIN	1.22e-04	9	35	2	IPR008962
Domain	SCAN	ZNF75D ZNF397 ZSCAN21	1.56e-04	56	35	3	SM00431
Domain	SCAN_BOX	ZNF75D ZNF397 ZSCAN21	1.73e-04	58	35	3	PS50804
Domain	SCAN	ZNF75D ZNF397 ZSCAN21	1.73e-04	58	35	3	PF02023
Domain	SCAN_dom	ZNF75D ZNF397 ZSCAN21	1.73e-04	58	35	3	IPR003309
Domain	Retrov_capsid_C	ZNF75D ZNF397 ZSCAN21	1.82e-04	59	35	3	IPR008916
Domain	Zinc_finger_PHD-type_CS	TRIM66 PYGO1	6.59e-03	65	35	2	IPR019786
Domain	PHD	TRIM66 PYGO1	8.69e-03	75	35	2	PF00628
Domain	Znf_PHD-finger	TRIM66 PYGO1	9.60e-03	79	35	2	IPR019787
Domain	PHD	TRIM66 PYGO1	1.21e-02	89	35	2	SM00249
Domain	Znf_PHD	TRIM66 PYGO1	1.26e-02	91	35	2	IPR001965
Domain	ZF_PHD_2	TRIM66 PYGO1	1.37e-02	95	35	2	PS50016
Domain	ZF_PHD_1	TRIM66 PYGO1	1.39e-02	96	35	2	PS01359
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF85 ZNF493 ZNF175 ZNF681	1.76e-07	49	35	4	9630514
Pubmed	Modulation of Ca(v)3.1 T-type Ca2+ channels by the ran binding protein RanBPM.	RANBP9 CACNA1G	9.84e-07	2	35	2	18801335
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	RANBP9 ZNF562 ZNF493 ZNF738 ZNF681	1.03e-06	181	35	5	37372979
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF85 ZNF493 ZNF681	3.35e-06	29	35	3	14563677
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RANBP9 TRIM66 CHD9 DCHS2 TMEM131 NCKAP5 PIAS1 GEN1 ERC1	3.70e-06	1285	35	9	35914814
Pubmed	A human MAP kinase interactome.	RANBP9 HELZ NCKAP5 PIAS1 ZNF175 PYGO1	8.31e-06	486	35	6	20936779
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	IBTK ZNF397 ZSCAN21 PIAS1 ZNF175 ZNF681 ZNF260	1.36e-05	808	35	7	20412781
Pubmed	Human cystathionine beta-synthase is a target for sumoylation.	RANBP9 PIAS1	2.06e-05	7	35	2	17087506
Pubmed	Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.	PIAS1 TP53BP1	3.53e-05	9	35	2	20016603
Pubmed	Protein phosphatase 1α interacting proteins in the human brain.	RANBP9 IBTK PIAS1	4.28e-05	67	35	3	22321011
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	IBTK GEN1 ZIM3 HYDIN ZNF175 PYGO1	5.74e-05	686	35	6	29987050
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF493 ZNF681	1.02e-04	15	35	2	15885501
Pubmed	Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2α.	RANBP9 PIAS1	1.17e-04	16	35	2	27068747
Pubmed	A physical interaction network of dengue virus and human proteins.	PIAS1 ERC1	1.49e-04	18	35	2	21911577
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	ZNF397 ZSCAN21 PIAS1	2.73e-04	125	35	3	32891193
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	HELZ PIAS1 ERC1 WDCP TP53BP1	2.90e-04	588	35	5	38580884
Pubmed	Tagging genes with cassette-exchange sites.	HELZ TMEM131 LEMD3 ZNF681	3.50e-04	335	35	4	15741177
Pubmed	Human transcription factor protein interaction networks.	HELZ ZSCAN21 PIAS1 WDCP TP53BP1 ZNF260 PYGO1	4.77e-04	1429	35	7	35140242
Pubmed	Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.	NCKAP5 ZNF562 TP53BP1	6.14e-04	165	35	3	16107646
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	IBTK LEMD3 ERC1 TP53BP1	6.56e-04	396	35	4	26687479
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	HELZ IBTK TMEM131 GEN1 ERC1	7.46e-04	724	35	5	36232890
Pubmed	Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.	RANBP9 PIAS1	7.49e-04	40	35	2	28805822
Cytoband	19p12	ZNF85 ZNF493 ZNF738 ZNF681	6.90e-07	90	35	4	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF85 ZNF493 ZNF738 ZNF681	2.33e-06	122	35	4	chr19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF677 ZIM3 ZNF175 ZNF260 ZNF256	1.99e-03	1192	35	5	chr19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr18q12	ZNF397 SETBP1	2.88e-03	104	35	2	chr18q12
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF75D ZNF677 ZNF397 ZNF85 ZNF562 ZNF493 ZSCAN21 ZIM3 ZNF175 ZNF681 ZNF260 ZNF256	4.54e-11	718	25	12	28
GeneFamily	PHD finger proteins	TRIM66 PYGO1	6.82e-03	90	25	2	88
CoexpressionAtlas	facebase_RNAseq_e10.5_MaxArch_2500_K3	CHD9 TMEM131 CACNA1G ZNF397 GEN1 ERC1 ZNF175 WDCP ZNF260	5.17e-05	1252	31	9	facebase_RNAseq_e10.5_MaxArch_2500_K3
ToppCell	390C-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZNF75D ZNF677 TP53BP1 ZNF681	1.15e-05	179	35	4	3edcd1356e49b1f5514c585861999e079ca5e579
Disease	alpha fetoprotein measurement	CHD9 GEN1 TP53BP1	1.91e-04	100	33	3	EFO_0010583
Disease	bladder exstrophy	NCKAP5 ZMAT4	1.11e-03	44	33	2	MONDO_0010805
Disease	Hypermetropia, Myopia	ZNF397 ZMAT4 PYGO1	1.22e-03	189	33	3	HP_0000540, HP_0000545
Disease	waist circumference	TRIM66 ZMAT4 PIAS1 SETBP1	1.29e-03	429	33	4	EFO_0004342
Disease	venous thromboembolism, fibrinogen measurement	CHD9 DCHS2	2.56e-03	67	33	2	EFO_0004286, EFO_0004623

Protein segments in the cluster

Peptide	Gene	Start	Entry
QTKGFHINHNTSEKS	ADGRF4	241	Q8IZF3
KAHQSYCHSNKHQSS	RANBP9	521	Q96S59
HFKSSHSNQTNHKPS	ERC1	991	Q8IUD2
HANHTGSNHTYLKNT	LEMD3	426	Q9Y2U8
SFVEELNSHHNKKHG	LEXM	266	Q3ZCV2
TNFTLGHGSQNSKHH	IBTK	151	Q9P2D0
KSLHHTQNDHFQNDG	HELZ	1131	P42694
KSSDHLQQHYNGKLH	DCHS2	1426	Q6V1P9
FHQQGHSHSMHQNKS	CHD9	141	Q3L8U1
KADSHGSGSQKQHHS	HYDIN	2156	Q4G0P3
QAQQHSRSHSKISKH	CACNA1G	2176	O43497
KHSSQKHNSSHFKES	GEN1	821	Q17RS7
KHNSSHFKESGHNKL	GEN1	826	Q17RS7
KSNKSSLHPNRHGHS	PYGO1	321	Q9Y3Y4
KSHNSPHGCQSAHEK	NCKAP5	1126	O14513
TSNNHSKKGHCHQEP	HCAR3	361	P49019
EHQVASHHQSSNKNK	PIAS1	441	O75925
VKHFHANQTSKGHTG	SCLY	111	Q96I15
NFSQLSAHAKTHKGE	ZNF562	271	Q6V9R5
FQKSNLHSHQKTHSG	ZIM3	401	Q96PE6
HKFLNSNTHKTRHTG	ZNF738	186	Q8NE65
NHSSNFNKHHRIHTG	ZSCAN21	426	Q9Y5A6
AFSQKENFLSHQKHH	ZNF260	91	Q3ZCT1
HQKQHVGQKHFRSNG	ZNF256	136	Q9Y2P7
KGAKQSQHGSQHHAH	TMEM131	1281	Q92545
GAASVKQHHSSAHNK	TP53BP1	1896	Q12888
KQHHSSAHNKDIALG	TP53BP1	1901	Q12888
KHCKHNIHGNALFQS	ZNF677	541	Q86XU0
CGKSFSHNTNLHTHQ	ZNF75D	426	P51815
GHSFKQHSSLTQHQR	ZNF397	291	Q8NF99
FHKFSNLNGHKVRHT	ZNF681	151	Q96N22
HKLLNSNRHNTKHTG	ZNF493	36	Q6ZR52
GKAFNHFSHLTTHKI	ZNF85	376	Q03923
THIHFNQHKSEGNSL	WDCP	286	Q9H6R7
VQFGHHQKLKLSHFQ	TRIM66	436	O15016
KHQHSEAGHKASKNN	SETBP1	1211	Q9Y6X0
EQYHAHLKGSKHQTN	ZMAT4	211	Q9H898
FNGRSNFHKHQITHT	ZNF175	596	Q9Y473