Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF624 ZSCAN2 ZNF600 ZNF226 REST ZNF112 RAX2 ZNF548 ZNF425 RAX ZNF549 ZNF443 ZNF304 ZNF507	1.52e-06	1412	45	14	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF624 ZSCAN2 ZNF600 ZNF226 REST ZNF112 RAX2 ZNF548 ZNF425 RAX ZNF549 ZNF443 ZNF304 ZNF507	2.25e-06	1459	45	14	GO:0000977
GeneOntologyMolecularFunction	sulfate adenylyltransferase (ATP) activity	PAPSS2 PAPSS1	4.97e-06	2	45	2	GO:0004781
GeneOntologyMolecularFunction	sulfate adenylyltransferase activity	PAPSS2 PAPSS1	4.97e-06	2	45	2	GO:0004779
GeneOntologyMolecularFunction	adenylylsulfate kinase activity	PAPSS2 PAPSS1	4.97e-06	2	45	2	GO:0004020
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF624 ZSCAN2 ZNF600 ZNF226 REST ZNF112 RAX2 ZNF548 RAX ZNF549 ZNF304 ZNF507	1.36e-05	1244	45	12	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF624 ZSCAN2 ZNF600 ZNF226 REST ZNF112 RAX2 ZNF548 RAX ZNF549 ZNF304 ZNF507	1.69e-05	1271	45	12	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF624 ZSCAN2 ZNF600 ZNF226 ZNF112 RAX2 RAX	2.36e-04	560	45	7	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF624 ZSCAN2 ZNF600 ZNF226 ZNF112 RAX2 RAX	2.52e-04	566	45	7	GO:0001216
GeneOntologyMolecularFunction	adenylyltransferase activity	PAPSS2 PAPSS1	2.22e-03	31	45	2	GO:0070566
GeneOntologyMolecularFunction	protein kinase activator activity	SPDYA TAOK1 IL6ST	4.59e-03	149	45	3	GO:0030295
GeneOntologyBiologicalProcess	purine ribonucleoside bisphosphate biosynthetic process	PAPSS2 PAPSS1	4.87e-06	2	46	2	GO:0034036
GeneOntologyBiologicalProcess	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	PAPSS2 PAPSS1	4.87e-06	2	46	2	GO:0050428
GeneOntologyBiologicalProcess	sulfate assimilation	PAPSS2 PAPSS1	2.91e-05	4	46	2	GO:0000103
Domain	-	ZNF624 ZSCAN2 ZNF600 ZNF226 REST ZNF112 ZNF532 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304 ZNF507	2.58e-10	679	44	14	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF624 ZSCAN2 ZNF600 ZNF226 REST ZNF112 ZNF532 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304 ZNF507	3.44e-10	694	44	14	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF624 ZSCAN2 ZNF600 ZNF226 REST ZNF112 ZNF532 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304 ZNF507	1.44e-09	775	44	14	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF624 ZSCAN2 ZNF600 ZNF226 REST ZNF112 ZNF532 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304 ZNF507	1.49e-09	777	44	14	PS00028
Domain	Znf_C2H2-like	ZNF624 ZSCAN2 ZNF600 ZNF226 REST ZNF112 ZNF532 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304 ZNF507	2.03e-09	796	44	14	IPR015880
Domain	Znf_C2H2	ZNF624 ZSCAN2 ZNF600 ZNF226 REST ZNF112 ZNF532 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304 ZNF507	2.35e-09	805	44	14	IPR007087
Domain	ZnF_C2H2	ZNF624 ZSCAN2 ZNF600 ZNF226 REST ZNF112 ZNF532 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304 ZNF507	2.47e-09	808	44	14	SM00355
Domain	zf-C2H2	ZNF624 ZSCAN2 ZNF600 ZNF226 REST ZNF112 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304 ZNF507	4.06e-09	693	44	13	PF00096
Domain	KRAB	ZNF624 ZNF226 ZNF112 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304	1.24e-07	358	44	9	PS50805
Domain	KRAB	ZNF624 ZNF226 ZNF112 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304	1.24e-07	358	44	9	PF01352
Domain	KRAB	ZNF624 ZNF226 ZNF112 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304	1.60e-07	369	44	9	SM00349
Domain	KRAB	ZNF624 ZNF226 ZNF112 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304	1.64e-07	370	44	9	IPR001909
Domain	zf-C2H2_6	ZNF624 ZSCAN2 ZNF600 ZNF532 ZNF548 ZNF425 ZNF549 ZNF443	6.11e-07	314	44	8	PF13912
Domain	APS_kinase	PAPSS2 PAPSS1	5.42e-06	2	44	2	IPR002891
Domain	Sulphate_adenylyltransferase	PAPSS2 PAPSS1	5.42e-06	2	44	2	IPR002650
Domain	ATP-Sase_PUA-like_dom	PAPSS2 PAPSS1	5.42e-06	2	44	2	IPR025980
Domain	PUA_2	PAPSS2 PAPSS1	5.42e-06	2	44	2	PF14306
Domain	Sulfurylase_cat_dom	PAPSS2 PAPSS1	5.42e-06	2	44	2	IPR024951
Domain	ATP-sulfurylase	PAPSS2 PAPSS1	5.42e-06	2	44	2	PF01747
Domain	PUA-like_domain	PAPSS2 PAPSS1	9.04e-04	19	44	2	IPR015947
Domain	Rossmann-like_a/b/a_fold	PAPSS2 PAPSS1	4.61e-03	43	44	2	IPR014729
Domain	-	PAPSS2 PAPSS1	4.61e-03	43	44	2	3.40.50.620
Pathway	REACTOME_TRANSPORT_AND_SYNTHESIS_OF_PAPS	PAPSS2 PAPSS1	8.42e-05	6	34	2	M27027
Pathway	REACTOME_TRANSPORT_AND_SYNTHESIS_OF_PAPS	PAPSS2 PAPSS1	8.42e-05	6	34	2	MM14679
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF624 ZNF600 ZNF226 REST ZNF112 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304	2.72e-04	1387	34	11	M734
Pathway	KEGG_SULFUR_METABOLISM	PAPSS2 PAPSS1	4.33e-04	13	34	2	M18256
Pathway	WP_SULFATION_BIOTRANSFORMATION_REACTION	PAPSS2 PAPSS1	7.51e-04	17	34	2	M39483
Pubmed	A member of a family of sulfate-activating enzymes causes murine brachymorphism.	PAPSS2 PAPSS1	1.71e-06	2	46	2	9671738
Pubmed	Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse.	PAPSS2 PAPSS1	1.71e-06	2	46	2	9771708
Pubmed	Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms.	PAPSS2 PAPSS1	1.71e-06	2	46	2	11931637
Pubmed	Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm.	PAPSS2 PAPSS1	1.71e-06	2	46	2	22242175
Pubmed	Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells.	PAPSS2 PAPSS1	1.71e-06	2	46	2	10657990
Pubmed	Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization.	PAPSS2 PAPSS1	1.71e-06	2	46	2	10679223
Pubmed	QRX, a novel homeobox gene, modulates photoreceptor gene expression.	RAX2 RAX	1.03e-05	4	46	2	15028672
Pubmed	Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo.	PAPSS2 PAPSS1	1.71e-05	5	46	2	17436279
Pubmed	The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1.	TAOK1 PPM1F	1.12e-04	12	46	2	35027733
Pubmed	Conservation of notochord gene expression across chordates: insights from the Leprecan gene family.	PAPSS2 PAPSS1	1.54e-04	14	46	2	18798549
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF226 ZNF112	3.20e-04	20	46	2	12743021
Pubmed	Bardet-Biedl Syndrome Overview	BBS2 SDCCAG8	5.88e-04	27	46	2	20301537
Pubmed	Joint influence of small-effect genetic variants on human longevity.	CRYBG1 ADGRD1	9.35e-04	34	46	2	20834067
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	REST EML5 ADGRD1	1.08e-03	152	46	3	34299191
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF600 ZNF226 ZNF112 ZNF548 ZNF45 ZNF549 ZNF304 ZNF507	2.19e-05	1192	46	8	chr19q13
Cytoband	18q21.32	ZNF532 RAX	1.66e-04	19	46	2	18q21.32
Cytoband	19q13.2	ZNF226 ZNF112 ZNF45	6.07e-04	164	46	3	19q13.2
Cytoband	19q13.43	ZNF548 ZNF549	3.48e-03	87	46	2	19q13.43
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF624 ZSCAN2 ZNF600 ZNF226 ZNF112 ZNF532 ZNF548 ZNF45 ZNF425 ZNF549 ZNF443 ZNF304 ZNF507	1.51e-10	718	33	13	28
GeneFamily	Bardet-Biedl syndrome associated\|BBSome	BBS2 SDCCAG8	6.64e-04	21	33	2	980
GeneFamily	PRD class homeoboxes and pseudogenes	RAX2 RAX	1.22e-02	92	33	2	521
Coexpression	GSE15624_3H_VS_6H_HALOFUGINONE_TREATED_CD4_TCELL_UP	BBS2 CRYBG1 TAOK1 TTYH3 SDCCAG8	1.10e-05	171	45	5	M7105
Drug	adenosine 5'-phosphoselenate	PAPSS2 PAPSS1	3.82e-06	2	45	2	CID000440758
Drug	beta-methylene-APS	PAPSS2 PAPSS1	3.82e-06	2	45	2	CID000129324
Drug	thiosulfate	BBS2 PAPSS2 PAPSS1 MOCOS	1.89e-05	80	45	4	CID000001084
Drug	AC1MIY5S	PAPSS2 PAPSS1	3.81e-05	5	45	2	CID003082099
Drug	Oxybenzone [131-57-7]; Down 200; 17.6uM; MCF7; HT_HG-U133A	REST PAPSS2 ORAI2 ZNF45 IL6ST	4.25e-05	197	45	5	5410_DN
Drug	SePO3	PAPSS2 PAPSS1 MOCOS	4.52e-05	35	45	3	CID000001092
Disease	Bardet-Biedl syndrome	BBS2 SDCCAG8	3.43e-04	18	45	2	cv:C0752166
Disease	nephrotic syndrome (implicated_via_orthology)	LIPC COQ6	6.14e-04	24	45	2	DOID:1184 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSSVSTIRNQRYHIH	ADGRD1	591	Q6QNK2
VSHLTGYETERQRHN	COQ6	406	Q9Y2Z9
KHRRNRTTFTTYQLH	RAX2	26	Q96IS3
RRSYLELVTSNHHSV	ORAI2	31	Q96SN7
TNVVYQAHHVSRNKR	PAPSS2	16	O95340
DRKNNYVQHVRTHTG	REST	286	Q13127
VQLHHRYSRRNVVST	GPR176	336	Q14439
ARYSVQINSHVVHRS	MFHAS1	896	Q9Y4C4
SKYQHNESHSRVRRA	CRISPLD2	36	Q9H0B8
AHDHYTIAVRNTRLV	LIPC	126	P11150
QVRYRILAHFHTTAE	MOCOS	96	Q96EN8
VHSHVVRETTQRTYT	OBSCN	6331	Q5VST9
TNVTYQAHHVSRNKR	PAPSS1	26	O43252
ICQTIVSTNQYTHHR	FCAMR	106	Q8WWV6
YARNNHRSNVTAVHK	IDH3A	186	P50213
TVQYSTVVHSGYRHQ	IL6ST	756	P40189
HTRNQHVSASRVFQS	BBS2	46	Q9BXC9
YHRISRHINVFTNGR	DCDC2C	131	A8MYV0
FKRYVAHSTHVTNVR	EML5	1231	Q05BV3
GSIRHVVQDYRVSHI	CRYBG1	1111	Q9Y4K1
VTTYLTQEHHTLRVR	FAM135B	331	Q49AJ0
YAINTHHSRELRIVV	GARNL3	591	Q5VVW2
ARYAAVHVHTNAARQ	PPM1F	206	P49593
QVVATTARHSAAYRA	FUNDC2	11	Q9BWH2
QRERSVHHSGAVRNY	SPDYA	196	Q5MJ70
QYQRSLREHASRSIH	SDCCAG8	16	Q86SQ7
HYRNREHFATIRTAS	TAOK1	431	Q7L7X3
HHSDRYQTFLRVRAN	RNF220	296	Q5VTB9
IQFVTHYQHSSTQRR	SEC23B	481	Q15437
HYQHSSTQRRIRVTT	SEC23B	486	Q15437
HRRNRTTFTTYQLHE	RAX	136	Q9Y2V3
QTHVTKNCLHYTRRV	ZNF532	826	Q9HCE3
YRSNSSLIVHIRTHT	ZNF624	481	Q9P2J8
QASRYATVSERVHAQ	WASHC5	326	Q12768
QTTHSRQEYAHRSRE	ZNF549	201	Q6P9A3
VGHQQRIHTRERSYV	ZNF549	291	Q6P9A3
FSQRSQLVVHQRTHT	ZSCAN2	511	Q7Z7L9
SFRRNSHYQVHLVVH	ZNF226	511	Q9NYT6
TSTTYVGVRNHRRIH	ZNF507	766	Q8TCN5
SQRAYLQGHQRVHTR	ZNF112	731	Q9UJU3
RVYLTLQHARASSHI	TRIM51G	286	A0A3B3IT33
VYPSVFQRHERTHTA	ZNF443	431	Q9Y2A4
RYSSTFVRHQRVHTG	ZNF548	291	Q8NEK5
TLVQHQRVHTGERSY	ZNF304	321	Q9HCX3
FVRNSYLARHTRIHT	ZNF600	591	Q6ZNG1
HRATYSLRHANRTVA	TTYH3	116	Q9C0H2
SFTQQYRLTEHIRVH	ZNF425	646	Q6IV72
RSYLQAHQRVHTGER	ZNF45	596	Q02386