Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionglycine hydroxymethyltransferase activity

SHMT1 SHMT2

8.08e-0521802GO:0004372
GeneOntologyMolecularFunctionformyltetrahydrofolate dehydrogenase activity

ALDH1L1 ALDH1L2

8.08e-0521802GO:0016155
GeneOntologyMolecularFunctionthreonine aldolase activity

SHMT1 SHMT2

2.41e-0431802GO:0004793
GeneOntologyMolecularFunctionL-allo-threonine aldolase activity

SHMT1 SHMT2

2.41e-0431802GO:0008732
GeneOntologyMolecularFunctionazole transmembrane transporter activity

SLC19A3 SLC15A4 SLC47A1

2.44e-04141803GO:1901474
GeneOntologyMolecularFunctionaldehyde dehydrogenase (NAD+) activity

ALDH1L1 ALDH1L2 ALDH1B1

3.03e-04151803GO:0004029
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC46A2 ATP6V0C ABCA12 SLC30A8 ABCC5 COX15 SLC39A4 NDUFA4 SLC5A11 SLC9A4 SLC15A4 SLC47A1 SLC26A11

4.04e-0447718013GO:0022804
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

ATP6V0C SLC30A8 COX15 SLC39A4 NDUFA4 SLC5A11 SLC9A4 SLC15A4 SLC47A1 SLC26A11

4.18e-0430118010GO:0022853
GeneOntologyMolecularFunctionaldehyde dehydrogenase [NAD(P)+] activity

ALDH1L1 ALDH1L2 ALDH1B1

4.46e-04171803GO:0004030
GeneOntologyMolecularFunctionamide transmembrane transporter activity

SLC19A3 ABCC5 SLC15A4 SLC47A1

5.47e-04421804GO:0042887
GeneOntologyMolecularFunctionbasic amino acid transmembrane transporter activity

SLC7A7 SLC15A4 SLC47A1

7.34e-04201803GO:0015174
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

SLC19A3 SLC7A7 SLC22A16 SLC15A4 SLC47A1

9.26e-04831805GO:0015101
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC46A2 ATP6V0C ABCA12 SLC30A8 SLC19A3 ABCC5 COX15 SLC39A4 TMC4 NDUFA4 SLC7A7 SLC5A11 KCNK18 SLC9A4 SLC22A16 SLC35A4 SLC15A4 SCN3A PKD1 HRH1 SLC47A1 SLC26A11

9.75e-04118018022GO:0022857
Domain-

CAB39 TOGARAM1 TMCO6 HEATR5A FRYL HEATR1 ARID1B MROH1 CAB39L CTNND2 HEATR5B GCN1 IPO11

2.33e-07222179131.25.10.10
DomainARM-like

CAB39 TOGARAM1 TMCO6 HEATR5A FRYL HEATR1 ARID1B MROH1 CAB39L CTNND2 STKLD1 HEATR5B GCN1 IPO11

3.51e-0727017914IPR011989
DomainHEAT_REPEAT

TOGARAM1 HEATR5A HEATR1 MROH1 HEATR5B GCN1 IPO11

4.76e-06701797PS50077
DomainARM-type_fold

CAB39 TOGARAM1 TMCO6 HEATR5A FRYL HEATR1 THADA MROH1 CAB39L CTNND2 STKLD1 HEATR5B GCN1 IPO11

5.13e-0633917914IPR016024
DomainIF-2

MTIF2 EIF5B

9.13e-0521792PF11987
DomainMo25

CAB39 CAB39L

9.13e-0521792IPR013878
DomainMo25

CAB39 CAB39L

9.13e-0521792PF08569
Domain10_FTHF_DH

ALDH1L1 ALDH1L2

9.13e-0521792IPR011407
DomainSHMT

SHMT1 SHMT2

9.13e-0521792PF00464
DomainSer_HO-MeTrfase_PLP_BS

SHMT1 SHMT2

9.13e-0521792IPR019798
DomainIF2

MTIF2 EIF5B

9.13e-0521792PS01176
DomainSHMT

SHMT1 SHMT2

9.13e-0521792PS00096
DomainSer_HO-MeTrfase

SHMT1 SHMT2

9.13e-0521792IPR001085
DomainTIF_IF2_dom3

MTIF2 EIF5B

9.13e-0521792IPR023115
Domain-

MTIF2 EIF5B

9.13e-05217923.40.50.10050
DomainHEAT

TOGARAM1 HEATR1 MROH1 GCN1 IPO11

2.32e-04581795IPR000357
DomainDUF3523

ATAD3C ATAD3A

2.72e-0431792IPR021911
Domain-

ALDH1L1 ALDH1L2

2.72e-04317923.10.25.10
DomainGART_AS

ALDH1L1 ALDH1L2

2.72e-0431792IPR001555
DomainFormyl_trans_C

ALDH1L1 ALDH1L2

2.72e-0431792PF02911
DomainDUF3523

ATAD3C ATAD3A

2.72e-0431792PF12037
DomainFormyl_trans_C

ALDH1L1 ALDH1L2

2.72e-0431792IPR005793
DomainGART

ALDH1L1 ALDH1L2

2.72e-0431792PS00373
DomainAld_DH_CS_GLU

ALDH1L1 ALDH1L2 ALDH1B1

4.42e-04161793IPR029510
DomainLAM_G_DOMAIN

HSPG2 FAT1 FAT2 USH2A

4.67e-04381794PS50025
DomainAld_DH_CS_CYS

ALDH1L1 ALDH1L2 ALDH1B1

5.33e-04171793IPR016160
Domain-

ALDH1L1 ALDH1L2

5.41e-04417923.40.50.170
DomainFormyl_transf_N

ALDH1L1 ALDH1L2

5.41e-0441792IPR002376
DomainFormyl_trans_N

ALDH1L1 ALDH1L2

5.41e-0441792PF00551
DomainLaminin_G_2

HSPG2 FAT1 FAT2 USH2A

5.69e-04401794PF02210
DomainALDEHYDE_DEHYDR_CYS

ALDH1L1 ALDH1L2 ALDH1B1

6.35e-04181793PS00070
DomainALDEHYDE_DEHYDR_GLU

ALDH1L1 ALDH1L2 ALDH1B1

6.35e-04181793PS00687
Domain-

ALDH1L1 ALDH1L2 ALDH1B1

7.49e-041917933.40.605.10
DomainAldedh

ALDH1L1 ALDH1L2 ALDH1B1

7.49e-04191793PF00171
DomainAld_DH_C

ALDH1L1 ALDH1L2 ALDH1B1

7.49e-04191793IPR016163
DomainAld_DH_N

ALDH1L1 ALDH1L2 ALDH1B1

7.49e-04191793IPR016162
DomainAld_DH/histidinol_DH

ALDH1L1 ALDH1L2 ALDH1B1

7.49e-04191793IPR016161
DomainAldehyde_DH_dom

ALDH1L1 ALDH1L2 ALDH1B1

7.49e-04191793IPR015590
Domain-

ALDH1L1 ALDH1L2 ALDH1B1

7.49e-041917933.40.309.10
DomainLamG

HSPG2 FAT1 FAT2 USH2A

8.21e-04441794SM00282
Domain-

ALDH1L1 ALDH1L2

8.96e-04517921.10.1200.10
DomainS1P_rcpt

S1PR1 S1PR4

8.96e-0451792IPR004061
DomainPHOSPHOPANTETHEINE

ALDH1L1 ALDH1L2

8.96e-0451792PS00012
DomainFormyl_transferase_C-like

ALDH1L1 ALDH1L2

8.96e-0451792IPR011034
DomainPP-binding

ALDH1L1 ALDH1L2

8.96e-0451792PF00550
DomainACP_DOMAIN

ALDH1L1 ALDH1L2

8.96e-0451792PS50075
DomainDUF4371

FAM200A ZMYM6

8.96e-0451792IPR025398
DomainDUF4371

FAM200A ZMYM6

8.96e-0451792PF14291
DomainSpectrin

SYNE1 SPTA1 UTRN

1.33e-03231793PF00435
DomainPP-bd_ACP

ALDH1L1 ALDH1L2

1.34e-0361792IPR009081
PathwayREACTOME_METABOLISM_OF_FOLATE_AND_PTERINES

SHMT1 SHMT2 ALDH1L1 ALDH1L2

1.79e-05171364M27085
PathwayWP_DISORDERS_OF_FOLATE_METABOLISM_AND_TRANSPORT

SHMT1 SHMT2 ALDH1L1 ALDH1L2

2.87e-05191364M39777
PathwayREACTOME_METABOLISM_OF_FOLATE_AND_PTERINES

SHMT1 SHMT2 ALDH1L1 ALDH1L2

4.37e-05211364MM14763
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

SYNE1 PPFIA1 SHMT2 PSMD11 ITGA9 POLR3A NUP205 INTS5 SF3B3 UBR5 ATAD3A PPP1R16B HEATR5B GCN1 UTRN HSP90AA1

8.53e-085731851628330616
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PLXNA3 HSPG2 MAN2B1 MUS81 CBLC TMCO6 FRYL LRRK1 ATG2A C2CD2 FAT1 THADA INTS5 MROH1 TMCC2 PKD1 MTMR3 DOCK6 GCN1 ABTB2 RIC1 ARHGAP33

1.21e-0711051852235748872
Pubmed

Network organization of the human autophagy system.

CAB39 SHMT2 COX15 ATG2A NUP205 NUP155 TGFBRAP1 EIF5B CAB39L MAP3K15 HSD17B4 GCN1 UTRN

7.17e-074371851320562859
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KNTC1 TOGARAM1 THADA FAT2 ATAD3C SACS CEP72 ATAD3A TMCC2 DNAH17 WDR35 EIF5B RIC1

2.71e-064931851315368895
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

PLXNA3 KNTC1 MYO1A SYNE1 SPTA1 PPFIA1 CAMSAP3 MYO18A ABCC5 SYNPO HEATR1 PRPS1L1 NUP205 SF3B3 ATAD3C SACS ATAD3A EIF5B IFT122 ALDH1B1 HSD17B4 KIAA2012 HSP90AA1

2.82e-0614421852335575683
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

SYNE1 PPFIA1 CAMSAP3 DNM1L SYNPO ATAD3C SACS UBR5 ATAD3A CTNND2

2.95e-062811851028706196
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

COL6A3 SYNE1 SPTA1 MYO18A CEP72 ATAD3A PKD1 HSP90AA1

7.80e-06187185826460568
Pubmed

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.

DNM1L ATAD3C ATAD3A

8.13e-068185330914652
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

DNM1L PSMD11 HEATR1 NUP205 SF3B3 NUP155 ATAD3A SMU1 EIF5B DNAJB5 HSD17B4 GCN1 HSP90AA1 IPO11

9.13e-066381851433239621
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

HEATR5A SCN3A WDR35 HEATR5B DOCK6 ZMYM6 RIC1

1.90e-05153185710718198
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

PPFIA1 SHMT2 DNM1L PSMD11 HEATR1 NDUFA4 NUP205 NUP155 UBR5 ATAD3A MTMR3 SMU1 HOOK2 EDEM1 GCN1 UTRN ABTB2

1.97e-059741851728675297
Pubmed

Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.

EARS2 ESRRA SHMT2 COX15 QRICH1 TTC19 UBR5 ATAD3A ALDH1L2 MTIF2 HSD17B4 UTRN

2.26e-055151851231617661
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

ATP6V0C SYNE1 SLC39A4 TTC19 GBP5 SLC35A4 SACS SLC15A4 TMCC2 PKD1 PEX16 HRH1 CTNND2 SLC26A11

2.43e-056971851428298427
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

TPP2 CAB39 ATP6V0C SYNE1 SPTA1 PPFIA1 CAMSAP3 MYO18A DNM1L SYNPO ALDH1L1 NDUFA4 SF3B3 ATAD3C SACS ATAD3A SMU1 ALDH1B1 CTNND2 UTRN HSP90AA1

2.72e-0514311852137142655
Pubmed

Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene.

SHMT1 SHMT2

2.81e-05218529573390
Pubmed

Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties.

SHMT1 SHMT2

2.81e-052185230500180
Pubmed

"ATAD3C regulates ATAD3A assembly and function in the mitochondrial membrane".

ATAD3C ATAD3A

2.81e-052185238092275
Pubmed

Fast-evolving cofactors regulate the role of HEATR5 complexes in intra-Golgi trafficking.

HEATR5A HEATR5B

2.81e-052185238240799
Pubmed

Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.

SHMT1 SHMT2

2.81e-052185227530298
Pubmed

The impact of Aldehyde dehydrogenase 1 expression on prognosis for metastatic colon cancer.

ALDH1L1 ALDH1B1

2.81e-052185224953984
Pubmed

Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization.

SHMT1 SHMT2

2.81e-052185222220685
Pubmed

Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells.

CDH23 USH2A

2.81e-052185217360538
Pubmed

Cadherin 23-C Regulates Microtubule Networks by Modifying CAMSAP3's Function.

CAMSAP3 CDH23

2.81e-052185227349180
Pubmed

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.

SHMT1 SHMT2

2.81e-052185229073064
Pubmed

Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells.

SHMT1 SHMT2

2.81e-052185217482557
Pubmed

Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization.

SHMT1 SHMT2

2.81e-05218528505317
Pubmed

How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.

SHMT1 SHMT2

2.81e-052185225619277
Pubmed

The role of serine hydroxymethyltransferase isozymes in one-carbon metabolism in MCF-7 cells as determined by (13)C NMR.

SHMT1 SHMT2

2.81e-052185211516159
Pubmed

ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase.

ALDH1L1 ALDH1L2

2.81e-052185220498374
Pubmed

Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects?

SHMT1 SHMT2

2.81e-052185211386852
Pubmed

Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy.

RNF31 EARS2 SHMT2 DNM1L HEATR1 NUP205 ATAD3A GCN1 HSP90AA1

2.90e-05292185935545034
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

EARS2 SYNPO LRRK1 ATG2A NUP205 ARID1B INTS5 SF3B3 NUP155 SERINC1 EDEM1 DOCK6

2.93e-055291851214621295
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

SYNE1 TOGARAM1 UBR5 CEP72 TMCC2 WDR35 PPP1R16B GCN1

2.97e-05225185812168954
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

TPP2 KNTC1 EXOSC1 SHMT2 SYNPO PSMD11 HEATR1 POLR3A NUP205 THADA SF3B3 NUP155 UBR5 ATAD3A SMU1 EIF5B HOOK2 ALDH1B1 GCN1 HSP90AA1 IPO11

2.97e-0514401852130833792
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

COL6A3 EARS2 COX15 UBR5 MAP3K15 EDEM1 USH2A GCN1

3.57e-05231185836597993
Pubmed

Alternative splice variants encoding unstable protein domains exist in the human brain.

MYO18A FAT2 PPP1R16B

4.07e-0513185315491607
Pubmed

SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.

SYNE1 SHMT2 PSMD11 NUP205 SF3B3 NUP155 ATAD3A SMU1 HSD17B4 GCN1 HSP90AA1

4.18e-054631851134901782
Pubmed

The TIP60 Complex Is a Conserved Coactivator of HIF1A.

EARS2 HEATR1 FAT1 ATAD3A ALDH1B1 GCN1

4.62e-05120185627320910
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

ZNF131 EARS2 SYNE1 PPFIA1 MYO18A SHMT1 SHMT2 COX15 HEATR1 NDUFA4 THADA SF3B3 NUP155 SACS UBR5 ATAD3A MTIF2 SMU1 EIF5B IFT122 DNAJB5

4.72e-0514871852133957083
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

EARS2 PSMD11 QRICH1 HEATR1 NUP205 GPR180 THADA INTS5 NUP155 UBR5 ATAD3A SERINC1 SLC47A1 HEATR5B GCN1 IPO11

4.81e-059421851631073040
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

MAN2B1 RNF31 CAMSAP3 COX15 POLR3A NUP155 MTIF2 ASB3 IFT122 HOOK2 HSD17B4 EDEM1 RIC1

4.98e-056501851338777146
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

KNTC1 CAB39 PSMD11 NDUFA4 NUP205 MROH1 PKD1 WDR35 IFT122 HOOK2 GCN1 HSP90AA1

5.42e-055641851221565611
Pubmed

Novel Cul3 binding proteins function to remodel E3 ligase complexes.

FMOD LRRK1 POC1B WDR35

6.10e-0540185425011449
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

TPP2 HSPG2 SHMT2 DNM1L PSMD11 QRICH1 ATAD3C NUP155 ATAD3A ALDH1B1 HSD17B4 HEATR5B GCN1 HSP90AA1 IPO11

7.82e-058781851537223481
Pubmed

Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase.

ALDH1L1 ALDH1L2

8.41e-053185219933275
Pubmed

Association study between variants in LHCGR DENND1A and THADA with preeclampsia risk in Han Chinese populations.

LHCGR THADA

8.41e-053185229727258
Pubmed

Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes.

FAT1 FAT2

8.41e-053185215744052
Pubmed

ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.

ATAD3C ATAD3A

8.41e-053185228549128
Pubmed

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.

DNM1L UTRN

8.41e-053185218838687
Pubmed

Pooled genetic analysis identifies variants that confer enhanced susceptibility to PCOS in Indian ethnicity.

LHCGR THADA

8.41e-053185232416252
Pubmed

Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex.

NUP205 NUP155

8.41e-053185215703211
Pubmed

ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte-like 3T3-L1 cells.

ATAD3C ATAD3A

8.41e-053185238923254
Pubmed

Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients.

SHMT1 UTRN

8.41e-053185216049973
Pubmed

ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly.

ATAD3C ATAD3A

8.41e-053185234936866
Pubmed

Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells.

CDH23 PKD1

8.41e-053185221865467
Pubmed

Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3.

ATAD3C ATAD3A

8.41e-053185225375035
Pubmed

Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase.

ALDH1L1 ALDH1L2

8.41e-053185221238436
Pubmed

Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4.

S1PR1 S1PR4

8.41e-053185237657263
Pubmed

NGS nominated CELA1, HSPG2, and KCNK5 as candidate genes for predisposition to Balkan endemic nephropathy.

HSPG2 CELA1

8.41e-053185224949484
Pubmed

[ATAD3, a vital membrane-bound mitochondrial ATPase involved in tumor progression].

ATAD3C ATAD3A

8.41e-053185222192748
Pubmed

Macrophage mannose receptor on lymphatics controls cell trafficking.

MRC1 S1PR1

8.41e-053185218434610
Pubmed

Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis.

S1PR1 S1PR4

8.41e-053185228206609
Pubmed

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration.

S1PR1 S1PR4

8.41e-053185230877143
Pubmed

Proteomic identification of mitochondrial targets of arginase in human breast cancer.

SHMT1 SHMT2

8.41e-053185224223914
Pubmed

Affinity properties of phosvitin: interaction of phosvitin with serine hydroxymethyl transferase.

SHMT1 SHMT2

8.41e-053185210549165
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

PDE8A GDAP2 CAMSAP3 SHMT2 CDH23 HEATR1 BBS9 NUP205 THADA SF3B3 HAUS1 SERINC1 SMU1 WDR35 EIF5B IFT122 GCN1 IPO11 CHST3

8.71e-0513211851927173435
Pubmed

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.

PDE8A PSMD11 NRIP3 ATAD3A PKD1 HSP90AA1 IPO11

8.85e-05195185717110338
Pubmed

PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis.

PSMD11 HEATR1 SF3B3 UBR5 HSP90AA1

1.23e-0490185530699358
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

SYNE1 SHMT2 PSMD11 HEATR1 NUP205 SF3B3 NUP155 SACS UBR5 ATAD3A SMU1 EIF5B HSD17B4 HEATR5B GCN1 UTRN

1.27e-0410241851624711643
Pubmed

Hereditary Ataxia Overview

SYNE1 GDAP2 POLR3A FAT2 SACS

1.36e-0492185520301317
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CYP4V2 MAOA CAMSAP3 NAIP SYNPO FRYL C2CD2 TTC19 THADA SLC35A4 ATAD3A TGFBRAP1 CAB39L IFT122 HOOK2 ZSWIM4 DOCK6 UTRN FGGY RIC1

1.42e-0414891852028611215
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

KNTC1 PPFIA1 FRYL ARID1B UBR5 CEP72 MTMR3 DOCK6 UTRN IPO11

1.50e-044461851024255178
Pubmed

Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.

SYNE1 DNAH17 HEATR5B

1.58e-0420185321689717
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

MAOA EARS2 SHMT1 SHMT2 COX15 CHAT ALDH1L1 NDUFA4 TTC19 ATAD3C ATAD3A ALDH1L2 MTIF2 NIT1 ALDH1B1 HSD17B4

1.63e-0410471851618614015
Pubmed

Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.

ATAD3C ATAD3A

1.68e-044185236736924
Pubmed

The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy.

ATAD3C ATAD3A

1.68e-044185238250153
Pubmed

Liver sinusoidal endothelial cells depend on mannose receptor-mediated recruitment of lysosomal enzymes for normal degradation capacity.

MRC1 MAN2B1

1.68e-044185219026003
Pubmed

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis.

DNM1L UTRN

1.68e-044185212499352
Pubmed

ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.

ATAD3C ATAD3A

1.68e-044185235236834
Pubmed

Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors.

S1PR1 S1PR4

1.68e-044185222178384
Pubmed

Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells.

ATAD3C ATAD3A

1.68e-044185229242539
Pubmed

Snm1B interacts with PSF2.

MUS81 DCLRE1B

1.68e-044185223189151
Pubmed

FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase.

S1PR1 S1PR4

1.68e-044185218713968
Pubmed

RNA-seq analysis to identify novel roles of scleraxis during embryonic mouse heart valve remodeling.

HSPG2 FMOD

1.68e-044185224983472
Pubmed

Chaperone-Mediated Regulation of Choline Acetyltransferase Protein Stability and Activity by HSC/HSP70, HSP90, and p97/VCP.

CHAT HSP90AA1

1.68e-044185229311808
Pubmed

Leukodystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

EARS2 POLR3A PEX16 HSD17B4

2.14e-0455185424501781
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

SYNE1 MYO18A SHMT2 NUP205 ARID1B INTS5 SF3B3 SACS ATAD3A SMU1 EIF5B HSD17B4 DOCK6 GCN1 ARHGAP33 HSP90AA1

2.36e-0410821851638697112
Pubmed

Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.

ALDH1L1 ALDH1L2 ALDH1B1

2.42e-0423185318971422
Pubmed

Sphingosine-1-phosphate receptor 2.

S1PR1 S1PR4

2.78e-045185223879641
Pubmed

Sphingosine 1-Phoshpate Receptors are Located in Synapses and Control Spontaneous Activity of Mouse Neurons in Culture.

S1PR1 S1PR4

2.78e-045185235781853
Pubmed

ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels.

ATAD3C ATAD3A

2.78e-045185229898916
Pubmed

Expression analysis of ATAD3 isoforms in rodent and human cell lines and tissues.

ATAD3C ATAD3A

2.78e-045185224239551
Pubmed

Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis.

S1PR1 S1PR4

2.78e-045185227353364
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

PLXNA3 ZNF131 COL6A3 RBM11 RNF31 SHMT2 ABCC5 HEATR1 GREB1L NSUN5 FAT1 MROH1 PKD1 PEX16 MAP3K15 EDEM1 UTRN

2.86e-0412151851715146197
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

RNF31 SHMT2 PSMD11 HEATR1 POLR3A NUP205 NSUN5 SF3B3 NUP155 UBR5 ATAD3A SMU1 EIF5B DHRS2 ALDH1B1 GCN1 UTRN HSP90AA1

3.46e-0413531851829467282
Pubmed

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation.

SLC30A8 CPA1 CELA1

3.52e-0426185325186293
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

CAB39 HSPG2 COL6A3 SYNE1 TTC19 ARID1B HOOK2 DNAJB5 UTRN HSP90AA1

3.55e-044971851023414517
Pubmed

Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.

MAOA SHMT2 HSD17B4 HSP90AA1

3.61e-0463185417220478
Pubmed

Proteomic analysis of the mouse liver mitochondrial inner membrane.

ABCA12 SHMT2 COX15 NDUFA4 ATAD3C ATAD3A

3.63e-04175185612865426
Pubmed

Dissociation of heterotrimeric g proteins in cells.

CALCB S1PR1 EDNRA LHCGR HRH1 S1PR4

4.10e-04179185618577758
InteractionP2RY8 interactions

SLC39A4 HEATR1 C2CD2 NUP205 THADA MROH1 SERINC1 HOOK2 GCN1 IPO11

4.70e-0617917910int:P2RY8
InteractionGPR17 interactions

TSPAN15 KNTC1 SLC39A4 HEATR5A HEATR1 THADA INTS5 SACS SERINC1 HOOK2 HEATR5B IPO11

9.01e-0628317912int:GPR17
InteractionSLC22A16 interactions

TSPAN15 TLCD4 GBP5 SLC22A16 SERINC1

1.58e-05361795int:SLC22A16
InteractionGPR45 interactions

KNTC1 EARS2 SLC39A4 HEATR1 C2CD2 NUP205 THADA INTS5 MROH1 HOOK2 GCN1 IPO11

1.61e-0530017912int:GPR45
GeneFamilySolute carriers

SLC46A2 SLC30A8 SLC19A3 SLC39A4 SLC7A7 SLC5A11 SLC9A4 SLC22A16 SLC35A4 SLC15A4 SLC47A1 SLC26A11

2.84e-0539513012752
GeneFamilyCadherin related

CDH23 FAT1 FAT2

2.29e-0417130324
GeneFamilyAldehyde dehydrogenases

ALDH1L1 ALDH1L2 ALDH1B1

3.24e-04191303398
GeneFamilySphingosine 1-phosphate receptors|CD molecules

S1PR1 S1PR4

5.06e-0451302206
CoexpressionGSE37319_WT_VS_RC3H1_KO_CD44LOW_CD8_TCELL_UP

EARS2 SLC30A8 MYO18A DNM1L CPNE5 SF3B3 ATAD3A SLC15A4 FGGY

1.04e-061491829M8918
CoexpressionGSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_3H_IFNG_STIM_UP

EXOSC1 PSMD11 HEATR1 GSTA3 NUP205 HAUS1 MTIF2 CAB39L UTRN

3.76e-061741829M6296
ToppCellfacs-Heart-LA-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TFAP2E SHMT1 CBLC CPA1 SLC39A4 TMC4 SF3B3 CELA1 ALDH1B1 LYPD8

6.18e-0918618510ef93ac469eb4f63db036f14b442c1503b8c6de38
ToppCellfacs-Heart-LA-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TFAP2E SHMT1 CBLC CPA1 SLC39A4 TMC4 SF3B3 CELA1 ALDH1B1 LYPD8

6.18e-0918618510246503fd4e6ae24041c606b069eb5fb313e60f73
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

GALNT15 HSPG2 SYNPO ITGA9 CPNE5 PPP1R16B DOCK6 UTRN NOVA2

1.17e-07192185927ff3621e177e7932dd44dd6baa81551ea75a874
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TFAP2E ASTL NRIP3 IGDCC4 LRRC9 SLC9A4 CTNND2 ANKRD7

2.75e-0715418581e32969bee810adaf2d560f0824a16227df513d8
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

GALNT15 HSPG2 SYNPO ITGA9 CPNE5 NKAIN2 DOCK6 NOVA2

8.61e-0717918581ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|kidney / Disease (COVID-19 only), tissue and cell type

GALNT15 HSPG2 SYNPO ITGA9 CPNE5 S1PR1 UTRN NOVA2

1.35e-0619018581519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 SYNE1 ITGA9 PPP1R16B DOCK6 UTRN NOVA2

1.57e-061941858a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCellCOVID-19-kidney-PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

GALNT15 HSPG2 SYNPO CPNE5 S1PR1 PPP1R16B DOCK6 NOVA2

1.64e-061951858a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCellCOVID-19-kidney-VWF+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

GALNT15 HSPG2 SYNPO ITGA9 CPNE5 PPP1R16B DOCK6 NOVA2

1.70e-061961858b71b197cb92117dd9efaa13de000841901cc4ca8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 SYNE1 ITGA9 S1PR1 DOCK6 UTRN NOVA2

1.83e-061981858440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 SYNPO ITGA9 S1PR1 PPP1R16B UTRN NOVA2

1.83e-061981858b027a141ab531d0f5d6a26811a53427e7b0771dd
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 SYNPO ITGA9 S1PR1 PPP1R16B UTRN NOVA2

1.83e-061981858953630dbe3154b1b102b87de0feca2cbf124eabe
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

GALNT15 HSPG2 SYNPO ITGA9 S1PR1 DOCK6 UTRN NOVA2

1.83e-0619818588689090bce9ab6e8f122426a404037e572c6713b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 SYNPO ITGA9 S1PR1 PPP1R16B UTRN NOVA2

1.83e-0619818588e45551224fbb30c0658ad47dd98335ecf165437
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GALNT15 TLCD4 ESRRA TMTC2 GPR180 HRH1 NLRC3

3.32e-061511857c1461d0dd622a081187eba77f454d2663df2732e
ToppCellfacs-Marrow-KLS-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN15 MRC1 SPTA1 C2CD2 TMCC2 CELA1 OAZ3

5.28e-061621857860ebf2390b4ad86475ad54717cbefcf61cd3b2a
ToppCellfacs-Marrow-KLS-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN15 MRC1 SPTA1 C2CD2 TMCC2 CELA1 OAZ3

5.28e-06162185714e9f8aaba308619eb9da90796c336e76cedac1f
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

S1PR1 LHCGR GBP5 SCN3A PPP1R16B NOVA2 S1PR4

8.13e-0617318570b79e2a4fd19d524c24b69a6b524ffc6affdabe5
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

S1PR1 LHCGR GBP5 SCN3A PPP1R16B NOVA2 S1PR4

8.13e-061731857a2c1ef3f4d7e9f68fc77ee7c42a4727bdea5da94
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

S1PR1 LHCGR GBP5 SCN3A PPP1R16B NOVA2 S1PR4

8.13e-0617318574830136f1f1976e00ac9af9062a531ac42533041
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel-D175|Adult / Lineage, Cell type, age group and donor

GALNT15 SPTA1 MYO18A CPNE5 S1PR1 PPP1R16B NOVA2

9.43e-061771857c9f269765c7d5d29caab75910e51645606ed562e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 SYNPO ITGA9 NKAIN2 S1PR1 UTRN NOVA2

9.78e-0617818575f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALDH1L1 LY6G6F SLC15A4 HEATR5B SLC26A11 NXPH3 IPO11

1.09e-051811857709e9c7a60d5f98635b99895ce30bb87a9f7376d
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMTC2 S1PR1 SACS PPP1R16B DOCK6 UTRN IPO11

1.30e-0518618570ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSPAN15 HSPG2 CPNE5 TSPAN16 PPP1R16B NOVA2 IPO11

1.35e-05187185750d5730e2cd4951d3ad0641fc81ae9f6ddabafe7
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

HSPG2 SYNE1 CDH23 PPP1R16B DOCK6 UTRN NOVA2

1.60e-0519218578a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 ITGA9 NKAIN2 S1PR1 UTRN NOVA2

1.60e-051921857bacbaef1f230051335f4433e55db07a161b96b4c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 SYNPO ITGA9 NKAIN2 HRH1 UTRN NOVA2

1.65e-0519318570b328f725f6feba263783eaca60c142e80df90f3
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 ITGA9 NKAIN2 S1PR1 UTRN NOVA2

1.65e-0519318576a623acd1adad9a78eddc32ffedb16352ad3fdfa
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 ITGA9 PPP1R16B DOCK6 UTRN NOVA2

1.71e-051941857f5706ab6bc803606c4640ddd606617e4e797ccc9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 ITGA9 PPP1R16B DOCK6 UTRN NOVA2

1.71e-051941857f76808666fb875fc787751cbfd924d9be20a8192
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 SYNPO ITGA9 NKAIN2 S1PR1 UTRN NOVA2

1.71e-051941857b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCellfacs-Lung-3m|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HSPG2 COL6A3 ABCC5 ITGA9 ARID1B CELA1 LYPD8

1.77e-051951857c4648c0332c3826776f9ad3f5f803dbac2b4c0c0
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 ITGA9 PPP1R16B DOCK6 UTRN NOVA2

1.83e-0519618578ad8efb631164b46f0c082572270188e5ead20bf
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 ITGA9 S1PR1 ATAD3C PPP1R16B DOCK6 NOVA2

1.83e-051961857023312af38f816a44b407e0daa32590d953caf99
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 ITGA9 CPNE5 S1PR1 SCN3A PPP1R16B NOVA2

1.83e-05196185709a7edf4a7defb7fe70d9777dd9500ee8421ff31
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 ITGA9 CPNE5 S1PR1 SCN3A PPP1R16B NOVA2

1.83e-051961857e50d2c66d5c5cd25fdfecdcc4c8506a1d0a85755
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 ITGA9 PPP1R16B DOCK6 UTRN NOVA2

1.83e-0519618579606ea7e42f707e69ea891b3521037613b9675f5
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 SYNPO ITGA9 S1PR1 PPP1R16B UTRN NOVA2

1.83e-051961857e224338490691d92c1f70b57112fabdcc92b06a9
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

HSPG2 SYNE1 TMTC2 FRYL PPP1R16B UTRN NOVA2

1.89e-051971857f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

DNAH3 LRRC9 SLC9A4 CFAP221 WDR35 IFT122 ARHGAP33

1.95e-0519818576d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 ITGA9 PPP1R16B DOCK6 UTRN NOVA2

1.95e-0519818570a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 SYNE1 ITGA9 DOCK6 UTRN NOVA2

1.95e-051981857451003a21162eeae90739fdb502bb50b362d80c8
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 SYNPO ITGA9 S1PR1 UTRN NOVA2

2.01e-051991857f35e9c05d0a0339ff691b38564da7aad8e9218aa
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT15 HSPG2 SYNPO ITGA9 S1PR1 UTRN NOVA2

2.01e-05199185733f1669eeb701986b4dec409efdb6c06c3c41c2b
ToppCellMacroglial-Oligodendrocytes-OPALIN--|Macroglial / cells hierarchy compared to all cells using T-Statistic

PDE8A TMTC2 FRYL NKAIN2 GREB1L SLC5A11 PPP1R16B

2.08e-05200185726b989e30bbbaf30904ced03f6aae3dea25c732c
ToppCellMacroglial-Oligodendrocytes-OPALIN---|Macroglial / cells hierarchy compared to all cells using T-Statistic

PDE8A TMTC2 FRYL NKAIN2 GREB1L SLC5A11 PPP1R16B

2.08e-0520018571314664c1721e9ecb1e2c3482a039044b0fe50a9
ToppCellMacroglial-Oligodendrocytes-OPALIN|Macroglial / cells hierarchy compared to all cells using T-Statistic

PDE8A TMTC2 FRYL NKAIN2 GREB1L SLC5A11 PPP1R16B

2.08e-0520018575f75a9b8bcd49d9bbb1e9ce2de730eaec96369ca
ToppCellMacroglial-Oligodendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

PDE8A TMTC2 FRYL NKAIN2 GREB1L SLC5A11 PPP1R16B

2.08e-0520018574dbac2f2587e87ca5a0622f50439bb5447e93c7f
ToppCellMacroglial-Oligodendrocytes-OPALIN-|Macroglial / cells hierarchy compared to all cells using T-Statistic

PDE8A TMTC2 FRYL NKAIN2 GREB1L SLC5A11 PPP1R16B

2.08e-0520018578b229f095fc113aecfc94b64862a9e0fdcc363ce
ToppCellMacroglial-Oligodendrocytes-OPALIN----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

PDE8A TMTC2 FRYL NKAIN2 GREB1L SLC5A11 PPP1R16B

2.08e-052001857272909f4354f3ae22e2b2f8f35970e6b0e92cfe2
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 LRRC9 SLC9A4 CFAP221 KIAA2012 USH2A

4.52e-0515418569ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 LRRC9 SLC9A4 CFAP221 KIAA2012 USH2A

4.52e-05154185658072ce422d09f2de602580325eaac6c4ec6c136
ToppCellCOVID-19-kidney-Epithelial_(EC)|kidney / Disease (COVID-19 only), tissue and cell type

GALNT15 HSPG2 ITGA9 TSPAN16 CTNND2 NOVA2

5.59e-0516018560d4880f85565d8c540c94a8f8109147b3029279a
ToppCellfacs-SCAT-Fat-18m-Epithelial|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1A ABCA12 SPTA1 CBLC SLC39A4 LYPD8

5.99e-051621856341fa357ad7bdbef30864e8062f161e60185ffc9
ToppCellfacs-SCAT-Fat-18m-Epithelial-nan|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1A ABCA12 SPTA1 CBLC SLC39A4 LYPD8

5.99e-0516218567fa93efa2039d68a4e8214fa143bcd3368349a2d
ToppCellfacs-SCAT-Fat-18m-Epithelial-epithelial_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1A ABCA12 SPTA1 CBLC SLC39A4 LYPD8

5.99e-0516218567215f6eb2b65dea455e2eec722a9c38e6958b120
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MRC1 PDE8A TFAP2E CPA1 SLC7A7 IPO11

6.20e-051631856c21114826bee1b05b411984326fef6b6e0d05316
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MRC1 PDE8A TFAP2E CPA1 SLC7A7 IPO11

6.20e-0516318565d49414432db259a19df50d7944581d00b69f537
ToppCellnormal_Lymph_Node-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

RBM11 CARD16 NUP205 GBP5 ABTB2 RIC1

7.09e-051671856820472887f43b42ae7e44513ca3d5465fb4f71a7
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TFAP2E ASTL NRIP3 IGDCC4 LRRC9 ANKRD7

7.09e-051671856cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TFAP2E ASTL NRIP3 IGDCC4 LRRC9 ANKRD7

7.57e-05169185630141f76e9bfc2b4586429857c72dbc85ba65cc9
ToppCelldroplet-Marrow-nan-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 MAOA SPTA1 DNM1L GBP5 STKLD1

7.57e-0516918565f5bec13208f4c3b6eacbba180c8a6402743b76e
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE8A DCLRE1B INTS5 POC1B NIT1 HSD17B4

7.82e-051701856833b4f44ea1fa673dfc6b43ce45a79fe68ae3b05
ToppCell356C-Myeloid-Dendritic-cDC_proliferating_2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

FMOD CAMSAP3 ITGA9 SLC22A16 IFT122 IPO11

9.17e-0517518567de1023161233b64f11e130881c742f4cf2bff65
ToppCellPosterior_cortex-Macroglia|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

TSPAN15 SLC5A11 LY6G6F OLIG1 ABTB2 CHST3

9.17e-0517518568bc7a3856d04692989b2a1675ea6d9392261d55a
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA12 CPA1 SLC39A4 GSTA3 CELA1 LYPD8

9.17e-0517518567329ebb135fc4311ee9595729b62a5d152c9de8c
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Drd1_(Deep_layer_pyramidal_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MYO1A GDAP2 PSMD11 QRICH1 SF3B3 MTIF2

9.47e-0517618563c76a5c4ca2b378667cb155fbb9675519572b35d
ToppCellfacs-Lung-18m-Hematologic-Lymphocytic_NK_ILC-Alox5+_lymphocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RBM11 EARS2 BBS9 IGDCC4 LRRC9 ASB3

9.76e-0517718561730e640986e50943bd781b7d949bcc5b7c12dde
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN15 PLXNA3 SHMT1 BBS9 MTIF2 EDEM1

9.76e-051771856c6812679aa6522d03bd29144e71c5fae6a92325e
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN15 PLXNA3 SHMT1 BBS9 MTIF2 EDEM1

9.76e-051771856ff97398d2adb83063b7c53a264bfae86ea7ea304
ToppCellfacs-Lung-18m-Hematologic-Lymphocytic_NK_ILC-Alox5+_lymphocyte-Alox5+_lymphocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RBM11 EARS2 BBS9 IGDCC4 LRRC9 ASB3

9.76e-051771856b7cfa3776f58377e35830780650d236b5cceecee
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 S1PR1 UTRN ELMOD1 NOVA2 IPO11

1.04e-041791856abc6797bd3884aa75dca58fcb2523ee321243ab1
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 S1PR1 UTRN ELMOD1 NOVA2 IPO11

1.04e-0417918560b996d6e881f31e6b80d359f7caac70ecdeb9982
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

FRYL ITGA9 NKAIN2 S1PR1 PPP1R16B UTRN

1.04e-0417918562a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellCOVID-19-kidney-PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

GALNT15 SYNPO CPNE5 PPP1R16B DOCK6 NOVA2

1.07e-041801856493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GALNT15 HSPG2 CAMSAP3 S1PR1 IFT122 NOVA2

1.10e-0418118562c44c41b4e8a75ebdbaeb0c6cc5a03f17c44758c
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC19A3 CHAT S1PR1 SCN3A PPP1R16B IPO11

1.14e-041821856d22ab50b135482915687c70e6dad29bfe2bb2c68
ToppCellCerebellum-Macroglia-OLIGODENDROCYTE|Cerebellum / BrainAtlas - Mouse McCarroll V32

NKAIN2 SLC5A11 LY6G6F CELA1 OLIG1

1.19e-04115185515b2c11225802cc15c01165d84a755432f02d82f
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

GALNT15 PDE8A SYNPO CPNE5 DOCK6 NOVA2

1.24e-041851856673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCellLPS_only-Hematopoietic_Meg-Ery-Erythroid-Erythroid|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TLCD4 SPTA1 DCLRE1B SLC22A16 TMCC2 POC1B

1.28e-041861856e5014443e9d6e25943308483e20d48b776ae5373
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-lymphatic|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GALNT15 TSPAN15 MRC1 PPP1R16B ELMOD1 NOVA2

1.28e-0418618565d94e6dd2c92e0c46badeb1e6eb54b69af855a66
ToppCellLPS_only-Hematopoietic_Meg-Ery-Erythroid|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TLCD4 SPTA1 DCLRE1B SLC22A16 TMCC2 POC1B

1.28e-041861856affc246a1091e44dc85a5e237c778a7541d5a2b4
ToppCellLPS_only-Hematopoietic_Meg-Ery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TLCD4 SPTA1 DCLRE1B SLC22A16 TMCC2 POC1B

1.28e-04186185640d1e15402fdfb3b5ae850a2070cd4b68fda3159
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALDH1L1 S1PR1 LRRC9 LHCGR CTNND2 KIAA2012

1.28e-041861856ac7a84b11b4550c4ac01eab370dc8ab88e4fb72b
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage_3|368C / Donor, Lineage, Cell class and subclass (all cells)

TSPAN15 MRC1 SLC19A3 SLC7A7 SLC47A1 S1PR4

1.28e-041861856ddfadd43efeac3b3e6b7062590cc2b8f2f2db2ab
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GALNT15 TSPAN15 MRC1 PPP1R16B ELMOD1 NOVA2

1.28e-0418618561da52e13096dfe4eb08bd0e7461cb3809b3b3deb
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPA1 SLC39A4 ALDH1L1 ITGA9 GSTA3 CELA1

1.32e-0418718569aa411ae9b5a923378a5daebb8bb2fc2613f2510
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

FRYL ITGA9 NKAIN2 S1PR1 PPP1R16B UTRN

1.32e-04187185640ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TMTC2 SLC9A4 CFAP221 SCN3A MAP3K15 ABTB2

1.32e-041871856f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCellmetastatic_Brain-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

MRC1 SLC19A3 ATG2A SLC7A7 SLC47A1 S1PR4

1.32e-0418718567375f70a970a5d5a58b7c33ada2dcf6dcef525c6
ToppCelldroplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TSPAN15 TMTC2 S1PR1 TMCC2 PPP1R16B NOVA2

1.36e-041881856db0652f000d459493321b53239326706eace598c
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature4_(5)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TSPAN15 MRC1 CPNE5 GBP5 PPP1R16B NOVA2

1.36e-041881856b9c5d573fc5ab0f7f38c55d006f9576634b05462
ToppCelldroplet-Fat-SCAT-30m-Endothelial-endothelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN15 SYNE1 S1PR1 SCN3A DOCK6 NOVA2

1.36e-0418818565cf060bb8adaefa9964187195d67993c1248ef47
ToppCelldroplet-Fat-SCAT-30m-Endothelial-Cd36+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN15 SYNE1 S1PR1 SCN3A DOCK6 NOVA2

1.36e-041881856e901a9bdf00b8e91806f445af66647373bf62661
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TSPAN15 PDE8A TMTC2 SLC5A11 OLIG1 ABTB2

1.36e-04188185614072d0b82df55711d5356b2209f4f0bdd90dc27
ToppCelldroplet-Fat-SCAT-30m-Endothelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN15 SYNE1 S1PR1 SCN3A DOCK6 NOVA2

1.36e-041881856449f9602df3c83b2110eb479a00d428d1b55b423
ToppCellfacs-Lung-EPCAM-18m-Epithelial-Basal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CBLC TMC4 FAT1 FAT2 HOOK2 NXPH3

1.40e-041891856783c1db856f2defe6f3b8748dd0bc29a8102f6d1
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TSPAN15 PDE8A TMTC2 SLC5A11 OLIG1 ABTB2

1.40e-041891856b60c8a29d3169c4830fe63b01db90c57660fc239
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 SYNPO ITGA9 NKAIN2 UTRN NOVA2

1.40e-04189185612b6f1c3bf526b90e112374bf937701f645c5780
DiseaseSynostotic Posterior Plagiocephaly

BBS9 WDR35 IFT122

1.14e-04161783C1833340
DiseaseCraniosynostosis, Type 1

BBS9 WDR35 IFT122

1.14e-04161783C4551902
DiseaseAcrocephaly

BBS9 WDR35 IFT122

1.14e-04161783C0030044
DiseaseTrigonocephaly

BBS9 WDR35 IFT122

1.14e-04161783C0265535
DiseaseScaphycephaly

BBS9 WDR35 IFT122

1.14e-04161783C0265534
DiseaseSynostotic Anterior Plagiocephaly

BBS9 WDR35 IFT122

1.14e-04161783C2931150
DiseaseMetopic synostosis

BBS9 WDR35 IFT122

1.14e-04161783C1860819
DiseaseBrachycephaly

BBS9 WDR35 IFT122

1.38e-04171783C0221356
DiseaseMigraine with or without aura, susceptibility to

EDNRA KCNK18

2.15e-0441782cv:CN300932
DiseaseCranioectodermal dysplasia

WDR35 IFT122

2.15e-0441782cv:C4551571
Diseaseneuromuscular disease (implicated_via_orthology)

ATAD3C ATAD3A

2.15e-0441782DOID:440 (implicated_via_orthology)
DiseaseMigraine

EDNRA KCNK18

2.15e-0441782cv:C0149931
DiseaseCraniosynostosis

BBS9 WDR35 IFT122

2.28e-04201783C0010278
DiseaseCRANIOECTODERMAL DYSPLASIA 1

WDR35 IFT122

3.58e-0451782C0432235
DiseaseAcidosis, Lactic

DNM1L ATAD3A

5.34e-0461782C0001125
Diseasesleep apnea measurement

SLC9A4 ARID1B SCN3A ASB3 ZMYM6

7.06e-041161785EFO_0007817
Diseaseheel bone mineral density, urate measurement

FBXO40 SPTA1 CAB39L UTRN ANKRD7 IPO11

8.57e-041821786EFO_0004531, EFO_0009270
Diseaseleukocyte immunoglobulin-like receptor subfamily B member 4 measurement

CDH23 CHST3

9.89e-0481782EFO_0801768
DiseaseDisproportionate short stature

HSPG2 WDR35 IFT122 CHST3

1.23e-03771784C0878659
Diseasemigraine (is_implicated_in)

EDNRA KCNK18

1.27e-0391782DOID:6364 (is_implicated_in)
DiseaseLeigh Syndrome due to Mitochondrial Complex V Deficiency

SLC19A3 COX15 TTC19

1.33e-03361783C1850600
DiseaseNecrotizing encephalopathy, infantile subacute, of Leigh

SLC19A3 COX15 TTC19

1.33e-03361783C2931891
DiseaseLeigh Syndrome due to Mitochondrial Complex III Deficiency

SLC19A3 COX15 TTC19

1.33e-03361783C1850598
DiseaseLeigh Syndrome Due To Mitochondrial Complex II Deficiency

SLC19A3 COX15 TTC19

1.33e-03361783C1850597
DiseaseLeigh Syndrome due to Mitochondrial Complex IV Deficiency

SLC19A3 COX15 TTC19

1.33e-03361783C1850599
DiseaseLEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY

SLC19A3 COX15 TTC19

1.44e-03371783C1838951
DiseaseOptic Atrophy

DNM1L ATAD3A

1.58e-03101782C0029124
Diseasephosphatidylcholine measurement

TDRD15 TLCD4 GREB1L MEI4 DOCK6 ZMYM6 ANKRD7

1.75e-032841787EFO_0010226
Diseaseneutrophil count

TSPAN15 GDAP2 NAIP MUS81 CDH23 PCDHA12 ABCC5 TMC4 DCLRE1B THADA TSPAN16 TGFBRAP1 TMCC2 PKD1 CELA1 DOCK6 FGGY S1PR4

1.82e-03138217818EFO_0004833
Diseasecomplement C1q tumor necrosis factor-related protein 1 measurement

CDH23 CHST3

2.30e-03121782EFO_0801493
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE1 HOOK2

2.30e-03121782DOID:11726 (implicated_via_orthology)
Diseasegranulins measurement

CDH23 CHST3

2.30e-03121782EFO_0008141
DiseaseAbruptio Placentae

GALNT15 TDRD15

2.30e-03121782EFO_1001754
DiseaseZellweger Spectrum

PEX16 HSD17B4

2.70e-03131782C3658299
DiseaseZellweger-Like Syndrome

PEX16 HSD17B4

2.70e-03131782C0751594
Diseasepulmonary emphysema (implicated_via_orthology)

MUS81 EDNRA

2.70e-03131782DOID:9675 (implicated_via_orthology)
DiseaseLeigh Disease

SLC19A3 COX15 TTC19

2.88e-03471783C0023264
Diseasemean corpuscular hemoglobin concentration

KNTC1 ZNF131 SPTA1 ABCC5 IGDCC4 SLC9A4 HAUS1 SLC22A16 UBR5 TMCC2 ASB3 MTMR3 HOOK2 KIAA2012 S1PR4

2.96e-03110517815EFO_0004528
Diseasehearing impairment

MYO1A CDH23 HSD17B4 USH2A

2.98e-03981784C1384666
DiseasePR interval

HSPG2 ABCA12 PPFIA1 ALDH1L1 ITGA9 PRPS1L1 FAT1 CAB39L CTNND2

3.25e-034951789EFO_0004462
Diseaselymphocyte count

ZNF131 SPTA1 PPFIA1 SLC30A8 CDH23 ABCC5 S1PR1 EDNRA SLC9A4 THADA DNAH17 ASB3 POC1B SLC47A1 ALDH1B1 HSD17B4 NLRC3 S1PR4

3.36e-03146417818EFO_0004587
Diseasethird ventricle volume measurement

NKAIN2 ABTB2

3.61e-03151782EFO_0010335
DiseaseAdrenoleukodystrophy, Neonatal

PEX16 HSD17B4

3.61e-03151782C0282525
Diseaseepithelial cell adhesion molecule measurement

TPP2 MTIF2 ASB3

3.63e-03511783EFO_0010574
DiseaseSpondyloepiphyseal Dysplasia

HSPG2 CHST3

4.11e-03161782C0038015
DiseaseZellweger Syndrome

PEX16 HSD17B4

4.11e-03161782C0043459
DiseaseSpondyloepiphyseal Dysplasia Tarda, X-Linked

HSPG2 CHST3

4.11e-03161782C3541456
DiseaseSchwartz-Jampel Syndrome, Type 1

HSPG2 CHST3

4.11e-03161782C4551479
DiseaseSchwartz-Jampel Syndrome

HSPG2 CHST3

4.11e-03161782C0036391
DiseaseMelnick-Needles Syndrome

HSPG2 CHST3

4.11e-03161782C0025237
DiseaseCiliopathies

CDH23 BBS9 WDR35 USH2A

4.50e-031101784C4277690
Diseasemuscular dystrophy (is_implicated_in)

COL6A3 SYNE1

4.64e-03171782DOID:9884 (is_implicated_in)
DiseaseVan Buchem disease

HSPG2 CHST3

4.64e-03171782C0432272
Diseasesyndrome (implicated_via_orthology)

ATAD3C ATAD3A

5.20e-03181782DOID:225 (implicated_via_orthology)
Diseaselevel of Phosphatidylinositol (18:0_18:1) in blood serum

TMC4 DOCK6

5.20e-03181782OBA_2045155
Diseaselifestyle measurement, alcohol consumption measurement

GSTA3 NUP205 HRH1 UTRN

5.26e-031151784EFO_0007878, EFO_0010724
Diseaseosteochondrodysplasia (is_implicated_in)

HSPG2 CHST3

5.78e-03191782DOID:2256 (is_implicated_in)
DiseaseOsteochondrodysplasias

HSPG2 CHST3

5.78e-03191782C0029422
DiseaseDyschondroplasias

HSPG2 CHST3

5.78e-03191782C0013366

Protein segments in the cluster

PeptideGeneStartEntry
KFAYILGSLSNLEEL

NAIP

1226

Q13075
QELYSSGLLVTLIAD

CAB39L

71

Q9H9S4
RDGTNVLYSALISLK

DNAJB5

256

O75953
INITDLAYNLLVSGA

ELMOD1

241

Q8N336
LEELVKLYLGSNNLT

CPN2

336

P22792
ALSILVLYQAGSLQA

CALCB

11

P10092
SGDFLLIYLANLEAK

CBLC

76

Q9ULV8
LVGQLYKSSLLDDLL

DNM1L

686

O00429
KTLEFAGQDLSAYLL

ACTL8

171

Q9H568
KVSGAYLSLLRALDN

ABCA12

1626

Q86UK0
FYSENNLGAVSLLLL

ABCA12

2061

Q86UK0
LSALYLASLIKEAGF

ALDH1B1

216

P30837
TIEALDSGAVYTLAL

ALDH1L2

526

Q3SY69
QLSKAAVTALASLYG

CPA1

331

P15085
GLTLLAVGVYSAKNA

ATAD3A

301

Q9NVI7
AQELYNSGLLSTLVA

CAB39

71

Q9Y376
NALIASLALGDLIYV

EDNRA

116

P25101
VTLANISGQLDLSAY

ARID1B

2096

Q8NFD5
LVSLEGIQYLTALES

CEP72

66

Q9P209
LYSLGKESLLEQLAL

DCLRE1B

181

Q9H816
LGEYNRAVSKLSAAL

CAMSAP3

696

Q9P1Y5
ASYEAAILENLALGT

CDH23

1316

Q9H251
DALLYVIQSALGSSE

CTNND2

741

Q9UQB3
YLSDIFGILNELSLK

FAM200A

346

Q8TCP9
NLSASDITRVLKLYG

ASTL

266

Q6HA08
DQLSLDLYKGSVALR

ATG2A

36

Q2TAZ0
ALTAFQNYLLESLKG

TFAP2E

401

Q6VUC0
QTLLLQALVYDAIKG

IGDCC4

1101

Q8TDY8
ESVSYAIALLNGIRL

RBM11

61

P57052
LAGIDTLLIRASYAQ

HSPG2

1081

P98160
LISSAVAELNYGLCL

QRICH1

516

Q2TAL8
ALVLGAVNDTLLYDS

RIC1

786

Q4ADV7
TGLIDYNQLALTARL

SHMT2

201

P34897
LSNSGYLKVLVDSLV

NUP205

1516

Q92621
YSAVLDAVIASAGLL

NSUN5

46

Q96P11
LSGNCYLKITALNLD

LRRC9

881

Q6ZRR7
YDVLVLKGSQLSARA

LY6G6F

121

Q5SQ64
LSAAKLLTEYGVSVL

MAOA

26

P21397
LNRKILYSLIDSADG

FAT1

3156

Q14517
LQAVYTLSLKAVDQG

FAT1

3191

Q14517
LSDIASLKALYQTGV

GDAP2

331

Q9NXN4
LLLLAGLFSLSQAQY

FMOD

6

Q06828
ARSLFSLVALDGKLY

KLHL33

311

A6NCF5
LVLGRLSYSIISNLD

KCNK18

256

Q7Z418
LKELYSAGNLTVLAT

OAZ3

96

Q9UMX2
VGYAALALALKAVAI

OR52W1

146

Q6IF63
QLILAAGSRLLVYDT

IFT122

26

Q9HBG6
YLLLIASVDSQTKGQ

LHCGR

411

P22888
EAAKASLGIYLTLTR

LINS1

451

Q8NG48
TALTALYLQVASIGA

NLRC3

946

Q7RTR2
DVLTGAALSQYRLLV

MTIF2

56

P46199
SVCLLKSLSELYLGN

LRRK1

566

Q38SD2
SSDLVATQARYLGLL

MYO1A

601

Q9UBC5
LSSGLAVAYVLNQID

HOOK2

31

Q96ED9
ALLIKDAVYNAVGLA

IPO11

446

Q9UI26
GQLKSALSEYVARLE

GALNT15

236

Q8N3T1
DYLVGNKLSRADISL

GSTA3

146

Q16772
ALQSRLDYATGLLKQ

PLXNA3

1371

P51805
LDYATGLLKQLLADL

PLXNA3

1376

P51805
GLYQDTALVKISLTQ

FAT2

1946

Q9NYQ8
QKAAYLLGCSLEELS

MYO18A

696

Q92614
AGSELAILYNDTAVL

PDE8A

611

O60658
NLVTYLAELLEKGLS

FRYL

2181

O94915
SSLQIVLALAGFIYA

NKAIN2

151

Q5VXU1
LYSVLRLNSAEAAAK

OR56B1

231

Q8NGI3
AGYIKDSVLLQDSQL

KIAA2012

176

Q0VF49
SGVLDTLTKVLVALY

MYCBP

21

Q99417
LSIGLKEYANNLIES

PPFIA1

1061

Q13136
NYDKILAISLVGSEL

KNTC1

1371

P50748
LAISLVGSELASLYQ

KNTC1

1376

P50748
LKNLVLTYVNAISSG

GBP5

291

Q96PP8
KVISLGDAQSNYLLT

EXOSC1

131

Q9Y3B2
GLALALNKLSQYLDS

GCN1

1236

Q92616
VAAGYDIALLRLAQS

CELA1

106

Q9UNI1
NYLITASSDGTLKIL

POC1B

241

Q8TC44
TALLLQAGSALANYI

GPR180

211

Q86V85
IGLSYALSAQAVLRL

OR52P1

216

Q8NH57
FYLSKSLGQILEAAV

MROH1

281

Q8NDA8
LLAISTALNTLASYG

NOVA2

276

Q9UNW9
LARNYILLLGSSLQE

OLIG1

156

Q8TAK6
VVILSKAAYSLLGSQ

GREB1L

1231

Q9C091
DTLLDGTYKQVIALA

BBS9

696

Q3SYG4
KELTGALIASLINCY

NUP155

831

O75694
KLSAQLLSISYVIGF

OR5AC2

141

Q9NZP5
KILVQYGADLLAVNS

PPP1R16B

151

Q96T49
LQKLNLLDCASYITG

PLA2G4E

396

Q3MJ16
YLALGAVKNISLNIS

ITGA9

646

Q13797
TESNLQYSLLLVLGL

ABCC5

211

O15440
LLLQYLETLSGLVDS

ARHGAP33

141

O14559
AAQYGKLESLSILIS

ASB3

186

Q9Y575
LLAKNLAILYSIGDT

HEATR5A

71

Q86XA9
LLAKNLAALYSIGDT

HEATR5B

71

Q9P2D3
LFVAALATVGLYLAQ

C2CD2

21

Q9Y426
VLKVVLYSLGSAQSA

DOCK6

1416

Q96HP0
SGISLAVNVLKELYQ

DNAH17

371

Q9UFH2
AELKGYNLLLGTVNA

DNAH3

566

Q8TD57
AILYLATVQAIALGT

FGGY

421

Q96C11
QANYSAAKLGLLGLA

HSD17B4

161

P51659
LLLLLTAGQSEDSYL

COL6A3

746

P12111
LVSDLLQALFKEAYS

C1orf112

116

Q9NSG2
YAVCGQSLSLVEKLL

ANKRD7

131

Q92527
AGLTLLAVGVYSAKN

ATAD3C

76

Q5T2N8
GASLVLSLLQRVASY

CYP4V2

26

Q6ZWL3
NDVLGNYSLTLVDAL

EDEM1

176

Q92611
LKYIAGFLDSVSLAQ

FBXO40

581

Q9UH90
GVQYILDSVISALLA

MAN2B1

96

O00754
KYLISLSGALAIVNA

MBTPS2

446

O43462
VGSKASLYLLALASL

LYPD8

216

Q6UX82
YLLSALAALQKVVET

HEATR1

1756

Q9H583
VGNLYIVSLSVADLI

HRH1

61

P35367
DLVILLYETALLSSG

HSP90AA1

661

P07900
AAVTLLALAYTQVGL

COX15

356

Q7KZN9
ALGVYNVSKTALLGL

DHRS2

181

Q13268
LERAAFYGITSNLVL

SLC15A4

46

Q8N697
YTAGSVLAQLLVSLA

SLC19A3

151

Q9BZV2
NLALSDLLAGVAYTA

S1PR1

86

P21453
DLLAGVAYTANLLLS

S1PR1

91

P21453
VNITLSDLLTGAAYL

S1PR4

86

O95977
SDLLTGAAYLANVLL

S1PR4

91

O95977
YLQVLSVLRDLATSG

SACS

1921

Q9NZJ4
YVLLKALALANSDSV

ESRRA

326

P11474
LSLALAQAGAEILTY

NIT1

211

Q86X76
SYLAETLGLSAALQA

CARD16

81

Q5EG05
LNAYALALTAVGEII

CPNE5

356

Q9HCH3
KLLILDARSYAAAVA

MTMR3

311

Q13615
LGVAYAQLAILLVSS

PKD1

4036

P98161
DIGVNSLLTYALSLN

PCDHA12

161

Q9UN75
YSNIKTVALNLLVTG

NXPH3

106

O95157
LILASYGATAQAVLR

OR2H1

211

Q9GZK4
INLSNVLLGESKTYV

CFAP221

166

Q4G0U5
AQSAYFIGLLISLDK

MRC1

856

P22897
GKEILYNLESLINSA

SHMT1

281

P34896
LQSSLYSGINLAVLL

MAP3K15

396

Q6ZN16
ALVDTGCLYNLISLA

NRIP3

121

Q9NQ35
AAVGLALLVSISNTY

MT-ND4L

71

P03901
YSASNLLVLLNDGIL

PEX16

51

Q9Y5Y5
EAVGTLASLISDYNL

MEI4

211

A8MW99
SLAFTQVDLLLGLSY

USH2A

1781

O75445
EQLTSLKVLYNDLGA

UTRN

1516

P46939
QSCLDILAGIYLSLS

THADA

76

Q6YHU6
TALLLADGSNVYLLA

TMCC2

226

O75069
YILTVEAGKQLLLSA

SYNE1

7621

Q8NF91
NLADILVASGLATYS

TDRD15

1901

B5MCY1
VVYLKENAALLTANG

SYNPO

271

Q8N3V7
ALLSSGQKDYVTVQL

SLC22A16

76

Q86VW1
VYVQASTLGSLEALL

EIF5B

981

O60841
GSRYLNALVDSAVAL

HAUS1

91

Q96CS2
DVQALVSGKLALRYA

PSMD11

266

O00231
ATGATLYLLRLALFN

NDUFA4

26

O00483
LNLASALTAFAGLYV

SLC39A4

561

Q6P5W5
AIQDFLTGAYLLTLK

POLR3A

541

O14802
AAETLYLSGILAITA

SLC9A4

316

Q6AI14
GLAAVIYTDALQTLI

SLC5A11

196

Q8WWX8
LGLLTALDLNYLTNK

MT-ND5

496

P03915
DVSLVSLVANALGYS

SCN3A

1281

Q9NY46
ELSLATQLYAGLVVS

INTS5

531

Q6P9B9
LAADKLLSAGATRVY

PRPS1L1

231

P21108
LELYAQATEALLKTG

EARS2

121

Q5JPH6
SALANLISQYTLALL

SLC47A1

216

Q96FL8
AALLSATALNYLLSL

SERINC1

196

Q9NRX5
LQLASAAGNYELVSL

ABTB2

611

Q8N961
IEALDAGAVYTLALK

ALDH1L1

506

O75891
AAGSALVYRDVLKQL

CHST3

181

Q7LGC8
ASLISGVLSYKALLD

CHAT

236

P28329
TLSTALNILEKYGRN

RNF31

71

Q96EP0
ASLTNVLGLSSAYLL

TSPAN16

41

Q9UKR8
QGLQLLLKYTSAATL

TRAV8-4

61

P01737
NAIIEISLKLASIYA

TTC19

176

Q6DKK2
YLEEVLLQRASASGK

TGFBRAP1

616

Q8WUH2
SLNYSGVKELILAVD

SLC30A8

281

Q8IWU4
AIYGLVVAVLIANSL

ATP6V0C

66

P27449
QNLIATYSEDGLLKL

SMU1

496

Q2TAY7
LSVGLTAIPQALAYA

SLC26A11

56

Q86WA9
AYRGLASLVKVSELA

STKLD1

566

Q8NE28
VALANSYGRLISELK

TMC4

671

Q7Z404
VSSALGLALYLNTLS

TMTC2

6

Q8N394
LYSDTINSLIGIAIA

SLC7A7

436

Q9UM01
VSFIGVLASLRDNLY

TSPAN15

76

O95858
LILSGLKANNIDYTV

TPP2

461

P29144
SLANVNIAIASGYLI

TLCD4

86

Q96MV1
NIAIASGYLISDLSI

TLCD4

91

Q96MV1
QVLSNLKIGSTAVLY

SLC35A4

116

Q96G79
AVLEALGYALSQLLQ

TMCO6

206

Q96DC7
ALILDIKYSTIGLAQ

SPTA1

2226

P02549
LSCSLLGDDALVQVY

SF3B3

506

Q15393
LETYSNLVSLGLAVS

ZNF582

36

Q96NG8
GKLAYLSDIFSLINE

ZMYM6

1111

O95789
VAASLYDAGLLLVVK

SLC46A2

31

Q9BY10
LALLADITSKYRQGD

ZNF131

211

P52739
SLVGFISLLYNLLDD

TOGARAM1

391

Q9Y4F4
ESAEYLKLITGLLNA

TOGARAM1

1486

Q9Y4F4
LLAEAALQKLDLYTA

WDR35

701

Q9P2L0
ALYSELLAVSSKGEL

UBR5

376

O95071
AYKLATLALAQLSIA

ZSWIM4

821

Q9H7M6
DKTLYLFAVGVLALS

TMEM272

146

A0A1B0GTI8
KESAAYLALLTRGLQ

MUS81

406

Q96NY9