Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoabnormal hepatic diverticulum morphology

BMP4 MAP2K4

1.08e-048282MP:0012234
MousePhenoabnormal liver bud morphology

BMP4 MAP2K4

1.08e-048282MP:0012235
MousePhenoabnormal embryo turning

BMP4 PNPLA6 COMMD1 GATAD2A PDHB

1.26e-04251285MP:0001700
DomainLRRC37_N

LRRC37A LRRC37A3 LRRC37A2

4.22e-084423IPR032754
DomainLRRC37AB_C

LRRC37A LRRC37A3 LRRC37A2

4.22e-084423PF14914
DomainLRRC37AB_C

LRRC37A LRRC37A3 LRRC37A2

4.22e-084423IPR029423
DomainLRRC37

LRRC37A LRRC37A3 LRRC37A2

4.22e-084423PF15779
DomainLRRC37A/B-like

LRRC37A LRRC37A3 LRRC37A2

4.22e-084423IPR015753
DomainLRR_8

LRRC37A LRRC37A3 LRRC37A2

6.66e-03171423PF13855
DomainLeu-rich_rpt_typical-subtyp

LRRC37A LRRC37A3 LRRC37A2

7.33e-03177423IPR003591
DomainLRR_TYP

LRRC37A LRRC37A3 LRRC37A2

7.33e-03177423SM00369
Pubmed

Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.

LRRC37A LRRC37A3 LRRC37A2

8.09e-09445322419166
Pubmed

Evolutionary dynamism of the primate LRRC37 gene family.

LRRC37A LRRC37A3 LRRC37A2

2.41e-071045323064749
Pubmed

Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease.

TAB2 FCRL3

1.64e-06245216384851
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

FAM184B AKT2 TANC1 PNPLA6 TELO2 SYNM PDHB BAG6 SDF2 RALGAPB

1.61e-051487451033957083
Pubmed

A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action.

AKT2 RALGAPB

3.42e-05745221148297
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

ZCCHC2 GTF3C1 BAG6 HECW2 RLIM

5.20e-0531345538270169
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

RIMS1 PNPLA6 GTF3C1 BAG6 ZNF768 RALGAPB ANKS1A

5.72e-0577445715302935
Pubmed

Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex.

AKT2 MAP2K4

5.86e-05945214504284
Pubmed

Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo.

TAB2 MAP2K4

8.94e-05114529162092
Pubmed

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

TAB2 AKT2 TANC1 KATNA1 ANKS1A

1.26e-0437845534315543
Pubmed

Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein.

BMP4 BBX

1.70e-041545232537777
Pubmed

Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.

BLNK TAB2 AKT2 MAP2K4

2.28e-0423145421048031
Pubmed

Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.

BAG6 RLIM

3.72e-042245224981174
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

TAB2 TANC1 SYNM ANKS1A

3.73e-0426345434702444
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

TAB2 MAP2K4 BAG6 SDF2 RLIM

3.84e-0448145528190767
Pubmed

The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.

BLNK BMP4

4.07e-042345215196959
Pubmed

The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.

BLNK MAP2K4

4.44e-042445221822214
Pubmed

Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.

PNPLA6 TELO2 BAG6 SDF2

4.85e-0428245435007762
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

COMMD1 GTF3C1 TELO2 BAG6

5.25e-0428845423383273
Pubmed

The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.

SORBS1 GTF3C1 PDHB BAG6 ZNF768

6.87e-0454745537267103
Pubmed

Genome-wide meta-analysis for severe diabetic retinopathy.

TAB2 MAP3K21

7.43e-043145221441570
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TAB2 SORBS1 TANC1 MAP3K21 RALGAPB ANKS1A

8.09e-0486145636931259
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

ADGRE5 LTBP2 RIMS1 RALGAPB

8.63e-0432945417474147
Pubmed

Gene expression profiling in the developing secondary palate in the absence of Tbx1 function.

BMP4 ANK1

8.94e-043445229866044
Pubmed

APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice.

BMP4 AKT2

8.94e-043445226411367
Pubmed

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.

KATNA1 PDHB

9.48e-043545219287380
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

AKT2 MAP2K4 GATAD2A GTF3C1 MAP3K21 PDHB

1.08e-0391045636736316
Pubmed

Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).

MAP2K4 LRRC37A

1.12e-033845222952603
Cytoband6q25.1

TAB2 KATNA1

6.46e-04384526q25.1
Cytoband17q21.31

LRRC37A LRRC37A2

2.97e-038245217q21.31
Cytoband19q13.43

ZNF543 ZNF542P

3.33e-038745219q13.43
CytobandEnsembl 112 genes in cytogenetic band chr19q13

AKT2 ZNF841 ZNF543 ZNF542P NCCRP1

6.05e-031192455chr19q13
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF12 ZNF841 ZNF543 ZNF542P ZNF768

7.02e-0371831528
GeneFamilyAnkyrin repeat domain containing

TANC1 ANK1 ANKS1A

8.07e-03242313403
CoexpressionGSE17721_LPS_VS_GARDIQUIMOD_6H_BMDC_UP

BLNK TAB2 TANC1 GATAD2A KATNA1 ANKS1A

1.02e-06200446M4050
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_B_emap-30374_k-means-cluster#2_top-relative-expression-ranked_100

SORBS1 RIMS1 SYNM

5.75e-0618423gudmap_developingLowerUrinaryTract_P1_bladder_B_100_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder detrusor (LCM)_emap-30376_k-means-cluster#4_top-relative-expression-ranked_500

SORBS1 RIMS1 SYNM AOX1

3.12e-0591424gudmap_developingLowerUrinaryTract_P2_bladder detrusor (LCM)_500_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_k-means-cluster#2_top-relative-expression-ranked_500

SORBS1 RIMS1 ANK1 SYNM

5.47e-05105424gudmap_developingLowerUrinaryTract_P1_bladder_J_500_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_adult_bladder_emap-29457_k-means-cluster#4_top-relative-expression-ranked_500

SORBS1 RIMS1 ANK1 SYNM

5.89e-05107424gudmap_developingLowerUrinaryTract_adult_bladder_500_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_adult_bladder_emap-29457_k-means-cluster#4_top-relative-expression-ranked_200

SORBS1 RIMS1 SYNM

6.26e-0539423gudmap_developingLowerUrinaryTract_adult_bladder_200_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_B_emap-30374_k-means-cluster#2_top-relative-expression-ranked_500

SORBS1 RIMS1 ANK1 SYNM

7.80e-05115424gudmap_developingLowerUrinaryTract_P1_bladder_B_500_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_adult_bladder_emap-29457_k-means-cluster#1_top-relative-expression-ranked_1000

SORBS1 RIMS1 ANK1 SYNM

2.06e-04148424gudmap_developingLowerUrinaryTract_adult_bladder_1000_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_k-means-cluster#1_top-relative-expression-ranked_100

RIMS1 SYNM

2.49e-0412422gudmap_developingLowerUrinaryTract_P1_bladder_J_100_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_adult_bladder_emap-29457_top-relative-expression-ranked_200

SORBS1 RIMS1 SYNM AOX1

2.78e-04160424gudmap_developingLowerUrinaryTract_adult_bladder_200
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder detrusor (LCM)_emap-30376_top-relative-expression-ranked_200

SORBS1 RIMS1 ANK1 SYNM

3.05e-04164424gudmap_developingLowerUrinaryTract_P2_bladder detrusor (LCM)_200
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_k-means-cluster#5_top-relative-expression-ranked_200

SORBS1 RIMS1 SYNM

3.44e-0469423gudmap_developingLowerUrinaryTract_P1_bladder_J_200_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder detrusor (LCM)_emap-30376_k-means-cluster#5_top-relative-expression-ranked_100

RIMS1 SYNM

5.10e-0417422gudmap_developingLowerUrinaryTract_P2_bladder detrusor (LCM)_100_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_adult_bladder_emap-29457_top-relative-expression-ranked_100

RIMS1 SYNM AOX1

5.13e-0479423gudmap_developingLowerUrinaryTract_adult_bladder_100
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_B_emap-30374_k-means-cluster#1_top-relative-expression-ranked_1000

SORBS1 RIMS1 ANK1 SYNM

5.54e-04192424gudmap_developingLowerUrinaryTract_P1_bladder_B_1000_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_B_emap-30374_top-relative-expression-ranked_100

SORBS1 RIMS1 SYNM

5.92e-0483423gudmap_developingLowerUrinaryTract_P1_bladder_100_B
CoexpressionAtlasDevelopingLowerUrinaryTract_adult_bladder_emap-29457_k-means-cluster#4_top-relative-expression-ranked_100

RIMS1 SYNM

6.39e-0419422gudmap_developingLowerUrinaryTract_adult_bladder_100_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_ureter_emap-30363_k-means-cluster#1_top-relative-expression-ranked_500

SORBS1 RIMS1 SYNM

6.57e-0486423gudmap_developingLowerUrinaryTract_P1_ureter_500_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_P2_bladder detrusor (LCM)_emap-30376_top-relative-expression-ranked_100

RIMS1 ANK1 SYNM

7.02e-0488423gudmap_developingLowerUrinaryTract_P2_bladder detrusor (LCM)_100
CoexpressionAtlasDevelopingLowerUrinaryTract_adult_bladder_emap-29457_top-relative-expression-ranked_500

SORBS1 RIMS1 ANK1 SYNM AOX1

8.62e-04378425gudmap_developingLowerUrinaryTract_adult_bladder_500
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

BLNK TAB2 SORBS1 SYNM

1.97e-05162444810881210e015c788814e4fe8d7a24c929cf2621
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MAP2K4 TANC1 CATSPER2 LRRC37A2

2.32e-051694446614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MAP2K4 TANC1 CATSPER2 LRRC37A2

2.32e-05169444665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCellASK428-Immune-B_cell|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

BLNK ZNF12 RIMS1 FCRL3

2.60e-05174444b5a7a612a515736cf3489afd0f6ad2054d54526f
ToppCellASK428-Immune-B_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

BLNK ZNF12 RIMS1 FCRL3

2.66e-05175444e0979e5795a49b4e5c9b88e7fe6b7bda7a413a6c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

BMP4 TANC1 ANK1 ALK

2.72e-0517644495d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCellILEUM-inflamed-(8)_Fibroblast-(8)_Smooth_muscle_cells|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

BMP4 SORBS1 RIMS1 SYNM

3.37e-05186444cacc2f0b2ed46516173b61ba1c5c226a2db7cddc
ToppCellControl-Endothelial_cells-Endothelial_cells_(general)|Control / group, cell type (main and fine annotations)

SORBS1 RIMS1 HECW2 ANKS1A

3.44e-05187444fb5bcbc8effdbf0e57fcb71aca990a4aa0d65ce8
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SORBS1 LTBP2 RIMS1 SYNM

3.44e-051874443912bbb610a4a84791e9bda92a2d57a52c31d29e
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

ZNF12 LTBP2 LRRC37A3 RALGAPB

3.52e-0518844414bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCellIPF-Endothelial-VE_Capillary_A|World / Disease state, Lineage and Cell class

SORBS1 TANC1 SYNM HECW2

3.59e-05189444ea3aa3ef38f1d405bb527ae383cd12c551a3dd6f
ToppCellIPF-Endothelial-VE_Capillary_A|IPF / Disease state, Lineage and Cell class

SORBS1 TANC1 SYNM HECW2

3.67e-05190444b4e35cbfe4d43d2cd51f29c3085e4d9b1012e6f0
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|390C / Donor, Lineage, Cell class and subclass (all cells)

MAP2K4 TANC1 CATSPER2 LRRC37A2

3.98e-0519444488db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|390C / Donor, Lineage, Cell class and subclass (all cells)

MAP2K4 TANC1 CATSPER2 LRRC37A2

3.98e-05194444a71728202493d4858342ea2756ea281cd0d99a3a
DiseaseMalignant neoplasm of breast

BMP4 AKT2 MAP2K4 SORBS1 FCRL3 LRRC37A ANK1 ALK LRRC37A2

1.64e-051074429C0006142
DiseaseBreast Carcinoma

BMP4 AKT2 MAP2K4 LRRC37A ALK LRRC37A2

1.07e-04538426C0678222
DiseaseBenign tumor of pancreas

AKT2 MAP2K4

1.53e-0413422C0347284
DiseasePancreatic carcinoma

AKT2 MAP2K4

3.33e-0419422C0235974
DiseaseOvarian Serous Adenocarcinoma

MAP2K4 ALK

4.91e-0423422C1335177
DiseaseMammary Carcinoma, Human

BMP4 AKT2 LRRC37A ALK LRRC37A2

8.65e-04525425C4704874
DiseaseMammary Neoplasms, Human

BMP4 AKT2 LRRC37A ALK LRRC37A2

8.65e-04525425C1257931
DiseaseMammary Neoplasms

BMP4 AKT2 LRRC37A ALK LRRC37A2

8.79e-04527425C1458155
Diseasechronic rhinosinusitis

LINC00587 ANKS1A

1.08e-0334422EFO_1000024
Diseasegranulocyte colony-stimulating factor measurement

ANK1 ALK

1.08e-0334422EFO_0008142
DiseaseNeoplasm of uncertain or unknown behavior of breast

AKT2 MAP2K4

1.57e-0341422C0496956
DiseaseBreast adenocarcinoma

AKT2 MAP2K4

1.57e-0341422C0858252
Diseasedepressive symptom measurement, stressful life event measurement

ZCCHC2 LINC00587

2.32e-0350422EFO_0007006, EFO_0007781

Protein segments in the cluster

PeptideGeneStartEntry
HTVTESRVLQNTRHP

AKT2

196

P31751
QGTRAIVHRNDHLPT

ERVPABLB-1

316

P60509
VHRGQRSTPLTHDGQ

BBX

911

Q8WY36
HLQGLSQAVPRHTIR

CATSPER2

31

Q96P56
PATSHPRVIRISHQS

BAG6

436

P46379
HQRGQARITHSPTVS

ANK1

1676

P16157
LVRPIQGSRTTIHLH

ADGRE5

571

P48960
AQIVRLLIHQGPSHT

ANKS1A

126

Q92625
THQGQHVRISRSLPQ

BMP4

246

P12644
GIGSTHTRIHPVQER

AOX1

91

Q06278
TGVQNPHIERLRTHS

MAP2K4

66

P45985
QSSRPTSALVHRQHL

HECW2

1021

Q9P2P5
AQQIHSIRQHSSTGP

GATAD2A

251

Q86YP4
ERQGTHITVVSHSRP

PDHB

231

P11177
DVITGHQHPQRTVSA

PNPLA6

271

Q8IY17
VQTQHSHLTRATVQP

LRRC37A3

651

O60309
VQTQHSHLTRATVQP

LRRC37A2

651

A6NM11
VQTQHSHLTRATVQP

LRRC37A

651

A6NMS7
RLQHLTSHEATPQGR

FAM184B

161

Q9ULE4
RTVIAQHHVAPRTSG

NCCRP1

206

Q6ZVX7
RHPGTTTFVQQRSLH

FAM218A

61

Q96MZ4
TTLTVPEQQRTTHHR

RIMS1

936

Q86UR5
HRGSSHRQEAVQSPV

BLNK

281

Q8WV28
HPSQQHVGLSRTVRL

LTBP2

286

Q14767
HSHGVSLRVTVPVSR

FCRL3

461

Q96P31
QSRHSAQIHTPVAII

COMMD1

131

Q8N668
HGNRPSTTVRVHRSS

KATNA1

126

O75449
RLRPTVLHSQTDHQG

LINC00587

51

B1AMM8
TSIRHISIGPQRHQT

SYNM

1306

O15061
QTGRNTPTSLHIHGV

TAB2

186

Q9NYJ8
HSTVHIVPQRRPASL

MAP3K21

936

Q5TCX8
VTHVQSGTAEHRPRN

TANC1

1706

Q9C0D5
SSAIRHTPLPQQRHV

TELO2

346

Q9Y4R8
PIRLTHVNTGRNLHS

SDF2

91

Q99470
TLAVSVHRHLQPSGR

ALK

346

Q9UM73
SRINGIRLSTPQHAH

ZCCHC2

596

Q9C0B9
TRQSTLIQHQRIHTG

ZNF542P

136

Q5EBM4
RHHVTLRQQISGPEL

RLIM

266

Q9NVW2
IAARRHTGVIPTHHQ

SORBS1

756

Q9BX66
SSLRSHQRVHTGQRP

ZNF768

386

Q9H5H4
VSTTPPHNRRHRAVT

RALGAPB

376

Q86X10
SQLVRHQIIHTGETP

ZNF841

326

Q6ZN19
THHQRIHTGRNPTIV

ZNF543

551

Q08ER8
THLTQHQRTHSGERP

ZNF12

366

P17014
SHVIRLPTGAQQHSI

GTF3C1

226

Q12789