Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnon-membrane spanning protein tyrosine kinase activity

TEC FYN EIF2AK2

1.96e-0446493GO:0004715
DomainProtein_kinase_ATP_BS

PIM1 STK39 TEC FYN EIF2AK2

3.07e-03379495IPR017441
DomainSET

SETD1B SETD6

5.18e-0341492PF00856
DomainSET

SETD1B SETD6

6.48e-0346492SM00317
DomainPROTEIN_KINASE_ATP

PIM1 STK39 TEC FYN EIF2AK2

6.88e-03459495PS00107
DomainSET_dom

SETD1B SETD6

7.62e-0350492IPR001214
DomainSET

SETD1B SETD6

7.62e-0350492PS50280
DomainProt_kinase_dom

PIM1 STK39 TEC FYN EIF2AK2

8.91e-03489495IPR000719
DomainSH3_1

SH3GL1 TEC FYN

9.11e-03164493PF00018
DomainPROTEIN_KINASE_DOM

PIM1 STK39 TEC FYN EIF2AK2

9.21e-03493495PS50011
Pubmed

Pim-1 associates with protein complexes necessary for mitosis.

PIM1 NUMA1

1.21e-05450212111331
Pubmed

Calpain II colocalizes with detergent-insoluble rafts on human and Jurkat T-cells.

CAPN2 FYN

2.02e-05550212150984
Pubmed

Cloning, expression and genetic mapping of the mouse SH3 domain protein, SH3D2B.

SH3GL1 EIF2AK2

3.03e-0565029434950
Pubmed

Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase.

OTOF STK39

5.64e-05850214563843
Pubmed

Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases.

TEC FYN

9.05e-051050215814670
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZNF469 FEZF2 DDX52 FAT3 PPFIA1 STK39 CBX4 RAB11FIP1

1.78e-04111650831753913
Pubmed

The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.

FYN EIF2AK2

1.82e-04145029151674
Pubmed

Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).

SH3GL1 FYN

2.10e-041550225036101
Pubmed

Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome".

GOLGA3 DNAH1

2.40e-041650229878059
Pubmed

Genes contributing to prion pathogenesis.

PRND FYN

3.41e-041950218559949
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

OTOF FAT3 PPFIA1 NUMA1

3.61e-0423450436243803
Pubmed

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.

SETD1B NALF1 PUM2 LRRC59 CBX4

3.82e-0443150533660365
Pubmed

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.

PPFIA1 SH3GL1 NUMA1 LRRC59 EIF2AK2

4.25e-0444150531239290
Pubmed

EG-1 interacts with c-Src and activates its signaling pathway.

TEC FYN

4.59e-042250216964398
Pubmed

Transcriptomic analysis of the upper lip and primary palate development in mice.

NUMA1 ENO3

5.48e-042450236685938
Pubmed

Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.

TEC FYN

5.95e-042550223873930
Pubmed

A chemical tool for blue light-inducible proximity photo-crosslinking in live cells.

EIF2AK2 GOLGA3

5.95e-042550235211260
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

AKR1B10 LRRC59 EIF2AK2 AHNAK2

6.01e-0426850433024031
Pubmed

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.

PPFIA1 CAPN2 AHNAK2

6.64e-0411850330979931
Pubmed

Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.

AKR1B10 NUMA1 LRRC59 AHNAK2

8.59e-0429550426209609
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

NMI GNE PPFIA1 SH3GL1 CAPN2 STK39 LAP3 AHNAK2

1.03e-03145550822863883
Pubmed

Identification and genetic mapping of the murine gene and 20 related sequences encoding chromosomal protein HMG-17.

PIM1 PRND

1.24e-03365028094303
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

CAPN2 NUMA1 GOLGA3 AHNAK2

1.33e-0333250437433992
Pubmed

Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

CBX4 EIF2AK2 LAP3

1.38e-0315250316009940
Cytoband2p22-p21

PUM2 EIF2AK2

3.24e-0585022p22-p21
CytobandEnsembl 112 genes in cytogenetic band chr2p23

CLIP4 OTOF ATAD2B

5.87e-04149503chr2p23
CytobandEnsembl 112 genes in cytogenetic band chr13q33

LIG4 NALF1

1.66e-0355502chr13q33
CoexpressionMIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP

NMI FAT3 AKR1B10 PRND RAB11FIP1 FYN

9.80e-06265496M2255
CoexpressionGSE13411_NAIVE_BCELL_VS_PLASMA_CELL_UP

DDX52 ATAD2B RAB11FIP1 FYN QRSL1

3.24e-05196495M3243
CoexpressionGSE10325_CD4_TCELL_VS_LUPUS_CD4_TCELL_DN

NMI CAPN2 RAB11FIP1 EIF2AK2 LAP3

3.49e-05199495M3093
CoexpressionGSE39820_CTRL_VS_TGFBETA1_IL6_CD4_TCELL_UP

SETD6 CBX4 FYN ENO3 QRSL1

3.49e-05199495M5604
ToppCellMesenchymal_cells-Osteoblasts|Mesenchymal_cells / Lineage and Cell class

ZNF469 GNE FAT3 LRRC59 ENO3

1.93e-06183505d6b52d52fe9a7a6c798947f05420d79fe12e4662
ToppCellMild-CD8+_T_activated|Mild / Disease group and Cell class

NMI OTOF PIM1 EIF2AK2 LAP3

2.83e-06198505ceac1b51bacfd0dd7fe7c6a666f7927055e1f380
ToppCell(03)_KRT6B+|World / shred by cell type by condition

PIM1 CBX4 RAB11FIP1 FYN AHNAK2

2.90e-061995059feaf8649b3f68f30b8cb6b045a2caa2dd343c7f
ToppCellP07-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CRACDL RAB11FIP1 ENO3 DNAH1

2.62e-051535045501095bcf73080872ae01128f21399f9cfc5dd1
ToppCellClub_cells-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

ERP27 OTOF DMRTA2 MINAR1

3.44e-051645044e25e6362ef793b08de2f4d1dccb6b1fc9c072a5
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOF PIM1 FYN ENO3

3.78e-05168504f45dbcd7753117a3e41e1412bce2100d52fa7fd0
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4|TCGA-Thryoid / Sample_Type by Project: Shred V9

CLIP4 CAPN2 AHNAK2 PHF13

5.38e-05184504d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AKR1B10 DMRTA2 AHNAK2 PHF13

5.73e-05187504a6a112689d1c9049f57935ad9d2f4955538427de
ToppCellCOVID-19-Myeloid-MoAM1,_IL1R2|Myeloid / Condition, Lineage and Cell class

NMI OTOF EIF2AK2 LAP3

6.35e-05192504be9d5685fa03563322f147a4b38ed31e4da59487
ToppCellcontrol-Myeloid-Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

NMI OTOF PIM1 EIF2AK2

6.61e-05194504267e213e8efe53aadfe553a2ca010a0e3b4b8939
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Mucous|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ATAD2B LRRC59 STK39 TEC

7.15e-051985042ae9564da9913510141994262f3739eb095e0a68
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

OTOF PIM1 EIF2AK2 LAP3

7.15e-0519850461ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCellSevere_COVID-19|World / Disease group,lineage and cell class (2021.01.30)

NMI OTOF CAPN2 LAP3

7.15e-0519850409fd456077bb3a657ad3b10c6cfe799b7266456a
ToppCellBAL-Severe|BAL / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NMI OTOF CAPN2 LAP3

7.15e-05198504454aee3f4fe6d0beeccc55200b4495f4f9b44feb
ToppCellBAL-Severe|BAL / Location, Disease Group, Cell group, Cell class (2021.03.09)

NMI OTOF CAPN2 LAP3

7.15e-05198504687f69c16343227854c882b4a0f3930ce534a3d2
ToppCellsevere|World / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

NMI PIM1 EIF2AK2 LAP3

7.29e-05199504c24aacef7405700bc5d0b736a38feea12b7f17c8
ToppCellBAL-Severe-cDC_1|Severe / Compartment, Disease Groups and Clusters

NMI PIM1 EIF2AK2 LAP3

7.29e-051995049f5750212b887f92761ade33fc6e108cd5275297
ToppCellmild-CD163+_Monocytes_(Sample_ID1_d7)|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

NMI OTOF EIF2AK2 LAP3

7.44e-0520050482126e25bfd8fba78dc1348fa5ad6a576289a139
ToppCellCOVID_non-vent|World / Disease condition, Lineage, Cell class and subclass

OTOF PIM1 EIF2AK2 LAP3

7.44e-05200504accef1050963dc91e189ac3d38228f15bf57e06e
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

NMI EIF2AK2 LAP3

4.27e-0450323GAVISH_3CA_METAPROGRAM_B_CELLS_INTERFERON
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

NMI EIF2AK2 LAP3

4.27e-0450323GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_INTERFERON
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

NMI SETD1B ATAD2B CAPN2 QRSL1 GABPB1

1.95e-061744967105_DN
DrugRamipril [87333-19-5]; Down 200; 9.6uM; PC3; HT_HG-U133A

SETD1B NALF1 SETD6 ATAD2B CAPN2 RAB11FIP1

4.11e-061984967144_DN
DrugAC1NSOON

PRND TEC

4.54e-062492CID005313274
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

NMI SETD1B CAPN2 NUMA1 GABPB1

3.67e-051754956736_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

NMI SETD1B CAPN2 NUMA1 GABPB1

3.67e-051754955908_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

NMI SETD1B CAPN2 QRSL1 GABPB1

5.04e-051874956671_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

NMI SETD6 CAPN2 QRSL1 GABPB1

5.44e-051904956709_DN
DrugThiocolchicoside [602-41-5]; Down 200; 7uM; HL60; HG-U133A

SETD1B DDX52 ATAD2B STK39 GABPB1

6.15e-051954951726_DN
DrugChloroquine diphosphate [50-63-5]; Down 200; 7.8uM; PC3; HT_HG-U133A

CLIP4 TMEM177 TGIF2 CAPN2 QRSL1

6.61e-051984957251_DN
Drug(R) -Naproxen sodium salt [26159-34-2]; Up 200; 15.8uM; MCF7; HT_HG-U133A

GABRR2 NALF1 DDX52 NUMA1 AHNAK2

6.77e-051994956794_UP
DrugPhenindione [83-12-5]; Down 200; 18uM; HL60; HG-U133A

TGIF2 DDX52 SH3GL1 CAPN2 GABPB1

6.77e-051994951718_DN
Drugestradiol, USP; Down 200; 0.1uM; MCF7; HT_HG-U133A

DDX52 ATAD2B AMDHD2 CBX4 FYN

6.77e-051994956968_DN
Diseasetyrosine-protein kinase TEC measurement

TEC TEC

1.68e-054502EFO_0020830
Diseaseobsolete_red blood cell distribution width

SETD1B PIM1 PCDHGA5 ATAD2B SH3GL1 HFM1 STK39 EIF2AK2 ENO3

3.87e-041347509EFO_0005192
Diseasecystathionine measurement

TEC TEC

4.72e-0419502EFO_0010474
Diseasedaytime rest measurement

NALF1 STK39 PREPL QRSL1

1.57e-03295504EFO_0007828
Diseasedifferentiated thyroid carcinoma

DMRTA2 FYN

1.62e-0335502EFO_1002017
Diseaseoppositional defiant disorder measurement

LIG4 NALF1

1.71e-0336502EFO_0007679
Diseasemyositis

TEC TEC

2.00e-0339502EFO_0000783
Diseaseattention deficit hyperactivity disorder, conduct disorder

LIG4 NALF1

2.11e-0340502EFO_0003888, EFO_0004216
Diseasespondylosis

LIG4 NALF1

2.11e-0340502MONDO_0002253
Diseasehigh grade glioma (is_implicated_in)

LIG4 SH3GL1

2.32e-0342502DOID:3070 (is_implicated_in)
Diseasemetachronous colorectal adenoma

NALF1 FAT3

2.66e-0345502EFO_0803377
Diseasemonokine induced by gamma interferon measurement

LIG4 NALF1

3.53e-0352502EFO_0008236
Diseasemacula measurement

ATAD2B STK39 FYN

4.06e-03189503EFO_0008375

Protein segments in the cluster

PeptideGeneStartEntry
DKLFEDGKTGFRDQL

DDX52

321

Q9Y2R4
QLDKEGNGLLDKADF

CAPS2

456

Q9BXY5
LSLKGKKLDFFGRGD

ADGRG4

26

Q8IZF6
DDKGNAIGGKATFLD

AKR1B10

126

O60218
LELRSAKGKNDGSVG

CLIP4

656

Q8N3C7
AGAGGSEAKLQKFDL

DMRTA2

181

Q96SC8
KGSFVGNIAKDLGLE

PCDHGA5

41

Q9Y5G8
LKQGDDDDSKINGRG

PUM2

146

Q8TB72
GENFDKLLAGKLRET

LAP3

56

P28838
SKGGNLRDKLDGNEL

LRRC59

6

Q96AG4
LRGEKKGDGDLSCIN

ATAD2B

146

Q9ULI0
LGKKLLEAARAGQDD

GABPB1

6

Q06547
DALGLSKLGGQAEKN

PPFIA1

841

Q13136
ALQAAKSGKEELDRG

GOLGA3

781

Q08378
AERGGAELRGAKKFS

CRACDL

561

Q6NV74
GFASGLNKDGIEAKL

HFM1

736

A2PYH4
LGRAGKLINGLSDEK

DNAH1

3116

Q9P2D7
LDDLEQLRGKASGKL

LIG4

596

P49917
AALAERKFGQGKGLE

GNE

521

Q9Y223
GDFGLVTSLKNDGKR

EIF2AK2

431

P19525
EKRYKNGQSLGDLDG

QRSL1

56

Q9H0R6
NKGSLLDFLKDGEGR

FYN

346

P06241
KANGKLNLEDGFLDF

FAT3

701

Q8TDW7
TDNRAKLDLGAQGKG

CBX4

101

O00257
GFLSGKLLKENRESE

ERP27

251

Q96DN0
ALELRDGDKGRYLGK

ENO3

46

P13929
AKLAKDREAAEGLGS

CAPN2

6

P17655
LGLSGEANAARKKGL

GABRR2

411

P28476
GALEADGSQGKKLLN

FEZF2

51

Q8TBJ5
DLRKISNDGDKGFLP

OTOF

516

Q9HC10
GKDQELAKLRGLEAA

NUMA1

1061

Q14980
ARNAGDKGKLTALDL

MINAR1

836

Q9UPX6
DLNRGELKLIDFGSG

PIM1

176

P11309
KEGLSFLGGLRSKND

RAB11FIP1

296

Q6WKZ4
KAEQLLRSEDKEGGF

TEC

256

P42680
FRELKDQDGGGDDKR

SETD6

381

Q8TBK2
SDALKRLKDGGLSAG

SETD1B

221

Q9UPS6
LGEDEGLLSLAGKRK

TGIF2

6

Q9GZN2
QKAKLDGARLEGDLS

AHNAK2

1961

Q8IVF2
GKEGYRGGLLKLEAA

PHF13

131

Q86YI8
GKELGGESNFGDALL

SH3GL1

101

Q99961
KQGRKLDIDFGAEGN

PRND

61

Q9UKY0
ADGRLTKKLNGLADL

PREPL

521

Q4J6C6
LKLFRKDLDSGGAAE

ZNF469

951

Q96JG9
RDLKAGNILLGEDGS

STK39

191

Q9UEW8
GNLALRSLLGKDGEK

TMEM177

256

Q53S58
NRGKDDRGKALFLGN

NALF1

146

B1AL88
GLEKSKGTLDFGADA

AMDHD2

366

Q9Y303
KLELSFSKSRNGGGE

NMI

176

Q13287