Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	extracellular matrix structural constituent	COL4A6 LAMB2 HMCN2 TECTA FBN3 EFEMP2	2.54e-06	188	42	6	GO:0005201
GeneOntologyBiologicalProcess	negative regulation of extracellular matrix constituent secretion	TNFRSF1A NOTCH1	2.31e-05	4	41	2	GO:0003332
GeneOntologyBiologicalProcess	regulation of extracellular matrix organization	LAMB2 TNFRSF1A NOTCH1 EFEMP2	2.31e-05	84	41	4	GO:1903053
GeneOntologyBiologicalProcess	positive regulation of transferase activity	ANGPT1 PPP1R3G PLAAT4 MUSK HLA-DRB1 DIPK2A ZFP91	4.57e-05	490	41	7	GO:0051347
GeneOntologyBiologicalProcess	endocardium morphogenesis	ANGPT1 NOTCH1	8.04e-05	7	41	2	GO:0003160
GeneOntologyBiologicalProcess	positive regulation of apoptotic process involved in morphogenesis	TNFRSF1A NOTCH1	8.04e-05	7	41	2	GO:1902339
GeneOntologyBiologicalProcess	circulatory system development	OBSL1 REST PTPRB TNFRSF1A ANGPT1 ERAP1 NOTCH1 WNT7A SMYD2 DIPK2A EFEMP2	8.39e-05	1442	41	11	GO:0072359
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	OBSL1 LAMB2 NTNG2 REST HMCN2 TECTA NOTCH1 WNT7A	9.52e-05	748	41	8	GO:0048667
GeneOntologyBiologicalProcess	positive regulation of apoptotic process involved in development	TNFRSF1A NOTCH1	1.07e-04	8	41	2	GO:1904747
GeneOntologyBiologicalProcess	neuron projection development	OBSL1 LAMB2 BICDL1 NTNG2 REST HMCN2 TECTA MUSK NOTCH1 WNT7A	1.61e-04	1285	41	10	GO:0031175
GeneOntologyBiologicalProcess	regulation of transferase activity	PTPRB ANGPT1 PPP1R3G PLAAT4 MUSK HLA-DRB1 DIPK2A ZFP91	1.65e-04	810	41	8	GO:0051338
GeneOntologyBiologicalProcess	regulation of extracellular matrix constituent secretion	TNFRSF1A NOTCH1	1.72e-04	10	41	2	GO:0003330
GeneOntologyBiologicalProcess	viral transcription	TRIM8 REST NOTCH1	2.08e-04	58	41	3	GO:0019083
GeneOntologyBiologicalProcess	negative regulation of calcium ion-dependent exocytosis	REST NOTCH1	2.10e-04	11	41	2	GO:0045955
GeneOntologyBiologicalProcess	extracellular matrix assembly	LAMB2 NOTCH1 EFEMP2	2.19e-04	59	41	3	GO:0085029
GeneOntologyBiologicalProcess	cardiac muscle cell myoblast differentiation	REST NOTCH1	2.51e-04	12	41	2	GO:0060379
GeneOntologyBiologicalProcess	endocardium development	ANGPT1 NOTCH1	2.97e-04	13	41	2	GO:0003157
GeneOntologyBiologicalProcess	inner ear auditory receptor cell differentiation	REST TECTA NOTCH1	3.20e-04	67	41	3	GO:0042491
GeneOntologyBiologicalProcess	vascular associated smooth muscle cell development	NOTCH1 EFEMP2	3.98e-04	15	41	2	GO:0097084
GeneOntologyBiologicalProcess	regulation of apoptotic process involved in morphogenesis	TNFRSF1A NOTCH1	3.98e-04	15	41	2	GO:1902337
GeneOntologyBiologicalProcess	extracellular matrix constituent secretion	TNFRSF1A NOTCH1	3.98e-04	15	41	2	GO:0070278
GeneOntologyBiologicalProcess	neuron development	OBSL1 LAMB2 BICDL1 NTNG2 REST HMCN2 TECTA MUSK NOTCH1 WNT7A	4.59e-04	1463	41	10	GO:0048666
GeneOntologyBiologicalProcess	glomerulus development	LAMB2 ANGPT1 NOTCH1	4.81e-04	77	41	3	GO:0032835
GeneOntologyBiologicalProcess	hair cell differentiation	REST TECTA NOTCH1	5.00e-04	78	41	3	GO:0035315
GeneOntologyBiologicalProcess	regulation of apoptotic process involved in development	TNFRSF1A NOTCH1	5.14e-04	17	41	2	GO:1904748
GeneOntologyBiologicalProcess	somatic stem cell division	NOTCH1 WNT7A	5.14e-04	17	41	2	GO:0048103
GeneOntologyBiologicalProcess	vasculogenesis involved in coronary vascular morphogenesis	ANGPT1 NOTCH1	5.78e-04	18	41	2	GO:0060979
GeneOntologyBiologicalProcess	cardioblast differentiation	REST NOTCH1	5.78e-04	18	41	2	GO:0010002
GeneOntologyBiologicalProcess	positive regulation of keratinocyte differentiation	PLAAT4 NOTCH1	6.45e-04	19	41	2	GO:0045618
GeneOntologyBiologicalProcess	heart development	OBSL1 REST TNFRSF1A ANGPT1 NOTCH1 SMYD2 DIPK2A	6.60e-04	757	41	7	GO:0007507
GeneOntologyBiologicalProcess	positive regulation of catalytic activity	REST ANGPT1 PPP1R3G PLAAT4 MUSK HLA-DRB1 DIPK2A ZFP91	8.15e-04	1028	41	8	GO:0043085
GeneOntologyBiologicalProcess	muscle tissue morphogenesis	ANGPT1 NOTCH1 EFEMP2	8.36e-04	93	41	3	GO:0060415
GeneOntologyBiologicalProcess	extracellular matrix organization	COL4A6 LAMB2 TNFRSF1A NOTCH1 EFEMP2	8.67e-04	377	41	5	GO:0030198
GeneOntologyBiologicalProcess	extracellular structure organization	COL4A6 LAMB2 TNFRSF1A NOTCH1 EFEMP2	8.77e-04	378	41	5	GO:0043062
GeneOntologyBiologicalProcess	external encapsulating structure organization	COL4A6 LAMB2 TNFRSF1A NOTCH1 EFEMP2	8.88e-04	379	41	5	GO:0045229
GeneOntologyBiologicalProcess	inner ear receptor cell differentiation	REST TECTA NOTCH1	9.16e-04	96	41	3	GO:0060113
GeneOntologyBiologicalProcess	blood vessel morphogenesis	PTPRB TNFRSF1A ANGPT1 ERAP1 NOTCH1 WNT7A EFEMP2	1.03e-03	817	41	7	GO:0048514
GeneOntologyBiologicalProcess	pulmonary valve development	TNFRSF1A NOTCH1	1.03e-03	24	41	2	GO:0003177
GeneOntologyBiologicalProcess	muscle organ morphogenesis	ANGPT1 NOTCH1 EFEMP2	1.09e-03	102	41	3	GO:0048644
GeneOntologyBiologicalProcess	regulation of viral transcription	TRIM8 NOTCH1	1.12e-03	25	41	2	GO:0046782
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen	ERAP1 HLA-DRB1	1.12e-03	25	41	2	GO:0002483
GeneOntologyBiologicalProcess	mechanoreceptor differentiation	REST TECTA NOTCH1	1.15e-03	104	41	3	GO:0042490
GeneOntologyBiologicalProcess	positive regulation of kinase activity	ANGPT1 MUSK HLA-DRB1 DIPK2A ZFP91	1.19e-03	405	41	5	GO:0033674
GeneOntologyBiologicalProcess	auditory receptor cell stereocilium organization	REST TECTA	1.22e-03	26	41	2	GO:0060088
GeneOntologyBiologicalProcess	negative regulation of extracellular matrix organization	TNFRSF1A NOTCH1	1.22e-03	26	41	2	GO:1903054
GeneOntologyBiologicalProcess	positive regulation of muscle cell differentiation	LAMB2 NOTCH1 EFEMP2	1.22e-03	106	41	3	GO:0051149
GeneOntologyBiologicalProcess	cell-substrate adhesion	LAMB2 ANGPT1 TECTA NOTCH1 EFEMP2	1.26e-03	410	41	5	GO:0031589
GeneOntologyBiologicalProcess	positive regulation of ERK1 and ERK2 cascade	ANGPT1 MUSK HLA-DRB1 NOTCH1	1.29e-03	240	41	4	GO:0070374
GeneOntologyBiologicalProcess	viral gene expression	TRIM8 REST NOTCH1	1.32e-03	109	41	3	GO:0019080
GeneOntologyBiologicalProcess	striated muscle cell proliferation	ANGPT1 NOTCH1 DIPK2A	1.36e-03	110	41	3	GO:0014855
GeneOntologyBiologicalProcess	positive regulation of smooth muscle cell differentiation	NOTCH1 EFEMP2	1.41e-03	28	41	2	GO:0051152
GeneOntologyBiologicalProcess	positive regulation of epidermal cell differentiation	PLAAT4 NOTCH1	1.41e-03	28	41	2	GO:0045606
GeneOntologyBiologicalProcess	epithelial cell differentiation	LAMB2 REST TNFRSF1A TECTA PLAAT4 NOTCH1 WNT7A	1.49e-03	870	41	7	GO:0030855
GeneOntologyBiologicalProcess	glomerulus vasculature development	ANGPT1 NOTCH1	1.62e-03	30	41	2	GO:0072012
GeneOntologyBiologicalProcess	vasculogenesis	ANGPT1 NOTCH1 WNT7A	1.66e-03	118	41	3	GO:0001570
GeneOntologyBiologicalProcess	positive regulation of molecular function	TRIM8 REST ANGPT1 PPP1R3G PLAAT4 MUSK HLA-DRB1 DIPK2A ZFP91	1.67e-03	1430	41	9	GO:0044093
GeneOntologyBiologicalProcess	kidney vasculature development	ANGPT1 NOTCH1	1.73e-03	31	41	2	GO:0061440
GeneOntologyBiologicalProcess	renal system vasculature development	ANGPT1 NOTCH1	1.73e-03	31	41	2	GO:0061437
GeneOntologyBiologicalProcess	auditory receptor cell morphogenesis	REST TECTA	1.73e-03	31	41	2	GO:0002093
GeneOntologyBiologicalProcess	negative regulation of cytokine production	RNF216 TNFRSF1A ANGPT1 HLA-DRB1 KLHL22	1.79e-03	444	41	5	GO:0001818
GeneOntologyBiologicalProcess	apoptotic process involved in morphogenesis	TNFRSF1A NOTCH1	1.84e-03	32	41	2	GO:0060561
GeneOntologyBiologicalProcess	negative regulation of regulated secretory pathway	REST NOTCH1	1.84e-03	32	41	2	GO:1903306
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous antigen	ERAP1 HLA-DRB1	1.84e-03	32	41	2	GO:0019883
GeneOntologyBiologicalProcess	positive regulation of epidermis development	PLAAT4 NOTCH1	1.96e-03	33	41	2	GO:0045684
GeneOntologyBiologicalProcess	negative regulation of stem cell differentiation	REST NOTCH1	1.96e-03	33	41	2	GO:2000737
GeneOntologyBiologicalProcess	epithelial cell development	LAMB2 TNFRSF1A NOTCH1 WNT7A	1.96e-03	269	41	4	GO:0002064
GeneOntologyBiologicalProcess	coronary vasculature morphogenesis	ANGPT1 NOTCH1	2.08e-03	34	41	2	GO:0060977
GeneOntologyBiologicalProcess	epidermis development	REST TECTA PLAAT4 HLA-DRB1 NOTCH1	2.11e-03	461	41	5	GO:0008544
GeneOntologyBiologicalProcess	cell morphogenesis	OBSL1 LAMB2 NTNG2 REST HMCN2 TECTA NOTCH1 WNT7A	2.13e-03	1194	41	8	GO:0000902
GeneOntologyBiologicalProcess	blood vessel development	PTPRB TNFRSF1A ANGPT1 ERAP1 NOTCH1 WNT7A EFEMP2	2.16e-03	929	41	7	GO:0001568
GeneOntologyBiologicalProcess	synapse organization	LAMB2 NTNG2 REST HMCN2 MUSK WNT7A	2.19e-03	685	41	6	GO:0050808
GeneOntologyBiologicalProcess	embryonic hindlimb morphogenesis	NOTCH1 WNT7A	2.20e-03	35	41	2	GO:0035116
GeneOntologyBiologicalProcess	regulation of kinase activity	PTPRB ANGPT1 MUSK HLA-DRB1 DIPK2A ZFP91	2.21e-03	686	41	6	GO:0043549
GeneOntologyCellularComponent	extracellular matrix	COL4A6 LAMB2 MUC5B ANGPT1 HMCN2 TECTA FBN3 WNT7A EFEMP2	6.06e-06	656	43	9	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	COL4A6 LAMB2 MUC5B ANGPT1 HMCN2 TECTA FBN3 WNT7A EFEMP2	6.21e-06	658	43	9	GO:0030312
GeneOntologyCellularComponent	basement membrane	COL4A6 LAMB2 HMCN2 EFEMP2	1.14e-04	122	43	4	GO:0005604
GeneOntologyCellularComponent	Schaffer collateral - CA1 synapse	RNF216 NTNG2 NOTCH1 WNT7A	2.87e-04	155	43	4	GO:0098685
GeneOntologyCellularComponent	microfibril	FBN3 EFEMP2	3.18e-04	13	43	2	GO:0001527
Domain	EGF-like_dom	LAMB2 NTNG2 HMCN2 TECTA FBN3 NOTCH1 EFEMP2	1.25e-06	249	42	7	IPR000742
Domain	EGF	LAMB2 NTNG2 TECTA FBN3 NOTCH1 EFEMP2	1.34e-05	235	42	6	SM00181
Domain	EGF_1	LAMB2 NTNG2 HMCN2 FBN3 NOTCH1 EFEMP2	2.12e-05	255	42	6	PS00022
Domain	EGF-like_CS	LAMB2 NTNG2 HMCN2 FBN3 NOTCH1 EFEMP2	2.42e-05	261	42	6	IPR013032
Domain	Growth_fac_rcpt_	LAMB2 HMCN2 FBN3 NOTCH1 EFEMP2	2.53e-05	156	42	5	IPR009030
Domain	EGF_2	LAMB2 NTNG2 HMCN2 FBN3 NOTCH1 EFEMP2	2.63e-05	265	42	6	PS01186
Domain	EGF_CA	HMCN2 FBN3 NOTCH1 EFEMP2	4.10e-05	86	42	4	PF07645
Domain	EGF_Ca-bd_CS	HMCN2 FBN3 NOTCH1 EFEMP2	6.58e-05	97	42	4	IPR018097
Domain	EGF_CA	HMCN2 FBN3 NOTCH1 EFEMP2	7.12e-05	99	42	4	PS01187
Domain	ASX_HYDROXYL	HMCN2 FBN3 NOTCH1 EFEMP2	7.41e-05	100	42	4	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	HMCN2 FBN3 NOTCH1 EFEMP2	9.29e-05	106	42	4	IPR000152
Domain	EGF_CA	HMCN2 FBN3 NOTCH1 EFEMP2	1.60e-04	122	42	4	SM00179
Domain	EGF-like_Ca-bd_dom	HMCN2 FBN3 NOTCH1 EFEMP2	1.70e-04	124	42	4	IPR001881
Domain	EGF_3	NTNG2 HMCN2 FBN3 NOTCH1 EFEMP2	1.76e-04	235	42	5	PS50026
Domain	EGF	NTNG2 TECTA FBN3 NOTCH1	1.81e-04	126	42	4	PF00008
Domain	TIL	MUC5B TECTA	3.21e-04	12	42	2	PF01826
Domain	C8	MUC5B TECTA	3.21e-04	12	42	2	PF08742
Domain	Unchr_dom_Cys-rich	MUC5B TECTA	3.79e-04	13	42	2	IPR014853
Domain	C8	MUC5B TECTA	3.79e-04	13	42	2	SM00832
Domain	TIL_dom	MUC5B TECTA	4.42e-04	14	42	2	IPR002919
Domain	LAMININ_NTER	LAMB2 NTNG2	5.81e-04	16	42	2	PS51117
Domain	VWFD	MUC5B TECTA	5.81e-04	16	42	2	PS51233
Domain	Laminin_N	LAMB2 NTNG2	5.81e-04	16	42	2	PF00055
Domain	VWD	MUC5B TECTA	5.81e-04	16	42	2	SM00216
Domain	VWF_type-D	MUC5B TECTA	5.81e-04	16	42	2	IPR001846
Domain	Laminin_N	LAMB2 NTNG2	5.81e-04	16	42	2	IPR008211
Domain	VWD	MUC5B TECTA	5.81e-04	16	42	2	PF00094
Domain	LamNT	LAMB2 NTNG2	5.81e-04	16	42	2	SM00136
Domain	VWC_out	MUC5B TECTA	8.24e-04	19	42	2	SM00215
Domain	Ig_I-set	OBSL1 HMCN2 IGLON5 MUSK	8.59e-04	190	42	4	IPR013098
Domain	I-set	OBSL1 HMCN2 IGLON5 MUSK	8.59e-04	190	42	4	PF07679
Domain	cEGF	FBN3 EFEMP2	1.55e-03	26	42	2	IPR026823
Domain	cEGF	FBN3 EFEMP2	1.55e-03	26	42	2	PF12662
Domain	hEGF	FBN3 NOTCH1	1.80e-03	28	42	2	PF12661
Domain	IGc2	OBSL1 HMCN2 IGLON5 MUSK	1.88e-03	235	42	4	SM00408
Domain	Ig_sub2	OBSL1 HMCN2 IGLON5 MUSK	1.88e-03	235	42	4	IPR003598
Domain	EGF_LAM_2	LAMB2 NTNG2	2.06e-03	30	42	2	PS50027
Domain	EGF_LAM_1	LAMB2 NTNG2	2.06e-03	30	42	2	PS01248
Domain	Laminin_EGF	LAMB2 NTNG2	2.80e-03	35	42	2	PF00053
Domain	EGF_Lam	LAMB2 NTNG2	2.80e-03	35	42	2	SM00180
Domain	VWC	MUC5B TECTA	3.30e-03	38	42	2	SM00214
Domain	Laminin_EGF	LAMB2 NTNG2	3.30e-03	38	42	2	IPR002049
Domain	VWFC_2	MUC5B TECTA	3.30e-03	38	42	2	PS50184
Domain	VWF_dom	MUC5B TECTA	4.02e-03	42	42	2	IPR001007
Domain	Ig-like_fold	OBSL1 PTPRB HMCN2 IGLON5 MUSK HLA-DRB1	4.69e-03	706	42	6	IPR013783
Domain	IG_LIKE	OBSL1 HMCN2 IGLON5 MUSK HLA-DRB1	4.69e-03	491	42	5	PS50835
Domain	Ig-like_dom	OBSL1 HMCN2 IGLON5 MUSK HLA-DRB1	5.20e-03	503	42	5	IPR007110
Domain	EGF_extracell	NTNG2 NOTCH1	8.05e-03	60	42	2	IPR013111
Domain	EGF_2	NTNG2 NOTCH1	8.05e-03	60	42	2	PF07974
Pubmed	Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding.	TNFRSF1A ERAP1	1.49e-06	2	43	2	12189246
Pubmed	Association of HLA-DRB1∗14, -DRB1∗16 and -DQB1∗05 with MuSK-myasthenia gravis in patients from Turkey.	MUSK HLA-DRB1	4.48e-06	3	43	2	23993985
Pubmed	An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release.	TNFRSF1A ERAP1	4.48e-06	3	43	2	18445477
Pubmed	An aminopeptidase, ARTS-1, is required for interleukin-6 receptor shedding.	TNFRSF1A ERAP1	4.48e-06	3	43	2	12748171
Pubmed	Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes.	TNFRSF1A ANGPT1	4.48e-06	3	43	2	32680471
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	PTPRB TNFRSF1A MUSK NOTCH1	7.58e-06	101	43	4	23382219
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	OBSL1 NTNG2 WDFY3 ANGPT1 ERAP1	8.54e-06	225	43	5	12168954
Pubmed	Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies.	PTPRB ANGPT1	1.49e-05	5	43	2	34663817
Pubmed	Tumor necrosis factor, tumor necrosis factor receptors type 1 and 2, lymphotoxin-alpha, and HLA-DRB1 gene polymorphisms in human T-cell lymphotropic virus type I associated myelopathy.	TNFRSF1A HLA-DRB1	1.49e-05	5	43	2	11163081
Pubmed	Regulation of tumor angiogenesis by the local environment.	ANGPT1 NOTCH1	1.49e-05	5	43	2	20036815
Pubmed	Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding.	RNF216 TNFRSF1A	2.23e-05	6	43	2	16968706
Pubmed	Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese.	TNFRSF1A ERAP1	2.23e-05	6	43	2	21068102
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TRIM8 OBSL1 RNF216 WDFY3 RAD54L2 R3HDM1 HLA-DRB1 SMYD2 EFEMP2	2.26e-05	1285	43	9	35914814
Pubmed	Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals.	COL4A6 LAMB2	3.12e-05	7	43	2	17418794
Pubmed	The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.	TECTA NOTCH1	4.16e-05	8	43	2	16141228
Pubmed	The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept.	TNFRSF1A HLA-DRB1	4.16e-05	8	43	2	15457442
Pubmed	Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.	PTPRB ANGPT1	4.16e-05	8	43	2	29358379
Pubmed	Association of IL23R, TNFRSF1A, and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the Finnish population.	TNFRSF1A HLA-DRB1	5.35e-05	9	43	2	18338763
Pubmed	Complex genetic predisposition in adult and juvenile rheumatoid arthritis.	TNFRSF1A HLA-DRB1	5.35e-05	9	43	2	15018649
Pubmed	GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.	ANGPT1 NOTCH1 WNT7A	5.45e-05	59	43	3	21421844
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	COL4A6 LAMB2 HMCN2 EFEMP2	5.47e-05	167	43	4	22159717
Pubmed	Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.	REST NOTCH1	6.68e-05	10	43	2	28489825
Pubmed	Notch-Tnf signalling is required for development and homeostasis of arterial valves.	TNFRSF1A NOTCH1	8.15e-05	11	43	2	26491108
Pubmed	Effects of varying Notch1 signal strength on embryogenesis and vasculogenesis in compound mutant heterozygotes.	ANGPT1 NOTCH1	8.15e-05	11	43	2	20346184
Pubmed	Multiple sclerosis susceptibility alleles in African Americans.	TNFRSF1A HLA-DRB1	1.15e-04	13	43	2	19865102
Pubmed	Opposing Effects of Growth and Differentiation Factors in Cell-Fate Specification.	REST NOTCH1	1.15e-04	13	43	2	31155355
Pubmed	Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase.	LAMB2 MUSK	1.35e-04	14	43	2	12441053
Pubmed	Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.	MUC5B NOTCH1	1.35e-04	14	43	2	22797898
Pubmed	KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.	TNFRSF1A NOTCH1	1.35e-04	14	43	2	25401743
Pubmed	The Notch target genes Hey1 and Hey2 are required for embryonic vascular development.	ANGPT1 NOTCH1	1.55e-04	15	43	2	15107403
Pubmed	Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.	ANGPT1 NOTCH1	1.55e-04	15	43	2	25072663
Pubmed	Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.	HLA-DRB1 ZFP91	1.55e-04	15	43	2	23349640
Pubmed	Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).	LAMB2 ANGPT1 ERAP1 HLA-DRB1 EFEMP2	1.60e-04	417	43	5	19199708
Pubmed	Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.	TNFRSF1A HLA-DRB1	2.01e-04	17	43	2	19879194
Pubmed	Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development.	PTPRB ANGPT1	2.26e-04	18	43	2	16514057
Pubmed	Chloride intracellular channel 4 is required for maturation of the cerebral collateral circulation.	ANGPT1 NOTCH1	2.26e-04	18	43	2	26276819
Pubmed	Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.	TNFRSF1A HLA-DRB1	2.52e-04	19	43	2	19525953
Pubmed	SRG3, a core component of mouse SWI/SNF complex, is essential for extra-embryonic vascular development.	ANGPT1 NOTCH1	2.52e-04	19	43	2	18206867
Pubmed	A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development.	ANGPT1 NOTCH1	2.80e-04	20	43	2	12588999
Pubmed	LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction.	MUSK WNT7A	3.09e-04	21	43	2	17119023
Pubmed	Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling.	NOTCH1 WNT7A	3.09e-04	21	43	2	26939553
Pubmed	Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations.	ANGPT1 NOTCH1	3.09e-04	21	43	2	18617694
Pubmed	Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior.	NOTCH1 WNT7A	4.05e-04	24	43	2	29086765
Pubmed	Continued expression of GATA3 is necessary for cochlear neurosensory development.	TECTA NOTCH1	4.05e-04	24	43	2	23614009
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	TRIM8 RNF216 HMCN2 R3HDM1	4.13e-04	283	43	4	18854154
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	LAMB2 NOTCH1 EFEMP2	4.26e-04	118	43	3	21078624
Pubmed	WD40 repeat and FYVE domain containing 3 is essential for cardiac development.	WDFY3 NOTCH1	4.40e-04	25	43	2	30428088
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	NTNG2 PTPRB SMYD2	4.58e-04	121	43	3	31900314
Pubmed	Congenital Myasthenic Syndromes Overview	LAMB2 MUSK	4.76e-04	26	43	2	20301347
Pubmed	Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.	COL4A6 LAMB2	4.76e-04	26	43	2	24742657
Pubmed	SCAP knockout in SM22α-Cre mice induces defective angiogenesis in the placental labyrinth.	ANGPT1 NOTCH1	5.14e-04	27	43	2	33227706
Pubmed	Extra-embryonic vasculature development is regulated by the transcription factor HAND1.	ANGPT1 NOTCH1	5.53e-04	28	43	2	15073150
Pubmed	Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice.	ANGPT1 NOTCH1	5.93e-04	29	43	2	17573777
Pubmed	Dosage-dependent requirement for mouse Vezf1 in vascular system development.	ANGPT1 NOTCH1	5.93e-04	29	43	2	15882861
Pubmed	SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron.	NOTCH1 WNT7A	5.93e-04	29	43	2	17928865
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	LAMB2 RAD54L2 R3HDM1 NOTCH1 EFEMP2	6.18e-04	560	43	5	21653829
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	COL4A6 LAMB2 TNFRSF1A R3HDM1 ERAP1 NOTCH1 DIPK2A	6.25e-04	1201	43	7	35696571
Pubmed	Heritable Thoracic Aortic Disease Overview	NOTCH1 EFEMP2	6.35e-04	30	43	2	20301299
Pubmed	Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling.	ANGPT1 WNT7A	6.35e-04	30	43	2	23349620
Pubmed	Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.	ANGPT1 WNT7A	6.79e-04	31	43	2	25053429
Pubmed	D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.	COL4A6 ANGPT1	6.79e-04	31	43	2	22925884
Pubmed	APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice.	TNFRSF1A NOTCH1	8.17e-04	34	43	2	26411367
Pubmed	Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).	ANGPT1 R3HDM1	9.67e-04	37	43	2	7584028
Pubmed	Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells.	REST NOTCH1	9.67e-04	37	43	2	27631609
Pubmed	Human colostrum: identification of minor proteins in the aqueous phase by proteomics.	MUC5B ERAP1 HLA-DRB1	1.07e-03	162	43	3	16502470
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	LAMB2 MUC5B ERAP1	1.11e-03	164	43	3	32409323
Pubmed	Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.	COL4A6 LAMB2	1.13e-03	40	43	2	27068110
Pubmed	Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.	MUC5B NOTCH1	1.19e-03	41	43	2	22675208
Cytoband	2q35	OBSL1 ZNF142	2.64e-03	79	44	2	2q35
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	LAMB2 RTP3 RAD54L2	3.47e-03	316	44	3	chr3p21
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	NTNG2 HMCN2 NOTCH1	3.76e-03	325	44	3	chr9q34
GeneFamily	Fibulins	HMCN2 EFEMP2	8.44e-05	8	32	2	556
GeneFamily	Immunoglobulin like domain containing	OBSL1 HMCN2 IGLON5 MUSK	3.58e-04	193	32	4	594
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	OBSL1 HMCN2 MUSK	2.84e-03	161	32	3	593
Coexpression	NABA_CORE_MATRISOME	COL4A6 LAMB2 NTNG2 HMCN2 TECTA FBN3 EFEMP2	3.57e-07	275	44	7	M5884
Coexpression	NABA_MATRISOME	COL4A6 LAMB2 MUC5B NTNG2 ANGPT1 HMCN2 TECTA FBN3 WNT7A EFEMP2 ZFP91	7.33e-07	1026	44	11	M5889
Coexpression	NABA_ECM_GLYCOPROTEINS	LAMB2 NTNG2 HMCN2 TECTA FBN3 EFEMP2	9.02e-07	196	44	6	M3008
Coexpression	NABA_CORE_MATRISOME	COL4A6 LAMB2 NTNG2 HMCN2 TECTA EFEMP2	5.74e-06	270	44	6	MM17057
Coexpression	NABA_ECM_GLYCOPROTEINS	LAMB2 NTNG2 HMCN2 TECTA EFEMP2	1.68e-05	191	44	5	MM17059
Coexpression	NABA_MATRISOME	COL4A6 LAMB2 MUC5B NTNG2 ANGPT1 HMCN2 TECTA WNT7A EFEMP2	3.74e-05	1008	44	9	MM17056
Coexpression	NABA_BASEMENT_MEMBRANES	COL4A6 LAMB2 NTNG2	4.18e-05	40	44	3	M5887
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN	TRIM8 PDXDC1 ANKRD30B RNF216 ZNF142 RAD54L2 HLA-DRB1 NOTCH1	1.15e-04	905	44	8	M40865
ToppCell	15-Trachea-Epithelial-Secretory_progenitor\|Trachea / Age, Tissue, Lineage and Cell class	LAMB2 MUC5B PTPRB FBN3 EFEMP2	1.12e-06	187	44	5	be9fce9e74b2f170a2067f1b31d802912a578329
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	REST TNFRSF1A PLAAT4 NOTCH1 EFEMP2	1.45e-06	197	44	5	965d5a3f8c9b12cb8a8d3429702ae29ebd8c6122
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial-Astroglia\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	REST TNFRSF1A PLAAT4 NOTCH1 EFEMP2	1.45e-06	197	44	5	3f088eb29197bc575400d6dafd8083e69e4a149f
ToppCell	facs-Kidney-nan-24m-Endothelial-fenestrated_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 PTPRB TNFRSF1A NOTCH1	3.59e-05	189	44	4	9d02a824bba59ea0660439f0510d843568e9d8c3
ToppCell	facs-Kidney-nan-24m-Endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 PTPRB TNFRSF1A NOTCH1	3.59e-05	189	44	4	5f8d4b61296c71b32362432a9ce4c1c3aaeb278d
ToppCell	facs-Kidney-nan-24m-Endothelial-Pecam____fenestrated_capillary_endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 PTPRB TNFRSF1A NOTCH1	3.59e-05	189	44	4	18f82764b32496e54d1a604a531b261651c5e110
ToppCell	droplet-Kidney-nan-21m-Endothelial-fenestrated_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 RTP3 PTPRB TNFRSF1A	4.06e-05	195	44	4	37d22a6448db1f83d098018fbb75a6dd8d9be302
ToppCell	droplet-Kidney-nan-21m-Endothelial-Pecam____fenestrated_capillary_endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 RTP3 PTPRB TNFRSF1A	4.06e-05	195	44	4	37592b7ad912b381b1edc77f4032983f26e0aa5b
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB HMCN2 HLA-DRB1 NOTCH1	4.14e-05	196	44	4	a20a56d8997d6db2a10046c8801c619a379de83c
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	COL4A6 LAMB2 REST NOTCH1	4.22e-05	197	44	4	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon\|organoid_Paulsen_bioRxiv / Sample Type, Dataset, Time_group, and Cell type.	LAMB2 TNFRSF1A PLAAT4 EFEMP2	4.22e-05	197	44	4	58b957efd006f43c2fe55071d5c6d06c2e367e72
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG-25\|World / Primary Cells by Cluster	COL4A6 LAMB2 REST NOTCH1	4.22e-05	197	44	4	9d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	ANGPT1 EML5 TMEM190 MUSK	4.30e-05	198	44	4	0c4d2c68a42f8a9e964e2dd28092fe75f5216834
Drug	Piribedil hydrochloride [78213-63-5]; Down 200; 12uM; PC3; HT_HG-U133A	COL4A6 LAMB2 NALF1 ERAP1 ZNF654 NOTCH1	2.28e-06	200	44	6	6333_DN
Drug	Suloctidil [54063-56-8]; Up 200; 11.8uM; PC3; HT_HG-U133A	BICDL1 R3HDM1 TECTA WNT7A KLHL22	2.89e-05	186	44	5	6675_UP
Drug	Naringenine [480-41-1]; Down 200; 14.6uM; MCF7; HT_HG-U133A	COL4A6 BICDL1 MUC5B WDFY3 EFEMP2	3.54e-05	194	44	5	4422_DN
Drug	Nifenazone [2139-47-1]; Down 200; 13uM; PC3; HT_HG-U133A	PLCB3 WDFY3 NALF1 RAD54L2 EFEMP2	3.62e-05	195	44	5	2122_DN
Drug	Dicumarol [66-76-2]; Down 200; 11.8uM; MCF7; HT_HG-U133A	COL4A6 RNF216 PLCB3 NALF1 PLAAT4	3.81e-05	197	44	5	3848_DN
Drug	Azapropazone [13539-59-8]; Up 200; 13.4uM; MCF7; HT_HG-U133A	OBSL1 COL4A6 RAD54L2 R3HDM1 ERAP1	3.90e-05	198	44	5	6522_UP
Drug	Metaproterenol sulfate, orciprenaline sulfate [5874-97-5]; Down 200; 7.6uM; MCF7; HT_HG-U133A	RNF216 PLCB3 RAD54L2 ERAP1 KLHL22	3.99e-05	199	44	5	4831_DN
Drug	Acetaminophen [103-90-2]; Up 200; 26.4uM; MCF7; HT_HG-U133A	RNF216 PLCB3 WDFY3 RAD54L2 KLHL22	3.99e-05	199	44	5	5384_UP
Drug	Nizatidine [76963-41-2]; Down 200; 12uM; PC3; HT_HG-U133A	RNF216 PLCB3 WDFY3 ERAP1 EFEMP2	3.99e-05	199	44	5	6305_DN
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	1.13e-05	95	43	4	EFO_0004529, EFO_0008317, EFO_0008596
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	1.74e-05	106	43	4	EFO_0008317, EFO_0008596
Disease	endometrial cancer (is_marker_for)	TNFRSF1A NOTCH1 EFEMP2	1.83e-05	35	43	3	DOID:1380 (is_marker_for)
Disease	cholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	2.02e-05	110	43	4	EFO_0008317, EFO_0008596, EFO_0010351
Disease	free cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	2.02e-05	110	43	4	EFO_0008317, EFO_0008591, EFO_0008596
Disease	chylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	2.02e-05	110	43	4	EFO_0004574, EFO_0008317, EFO_0008596
Disease	1-palmitoyl-2-dihomo-linolenoyl-GPC (16:0/20:3n3 or 6) measurement	PDXDC1 MUSK	2.07e-05	5	43	2	EFO_0800407
Disease	allergic bronchopulmonary aspergillosis (is_implicated_in)	TNFRSF1A HLA-DRB1	3.10e-05	6	43	2	DOID:13166 (is_implicated_in)
Disease	dihomo-linolenate 20:3n3 or n6 measurement	PDXDC1 MUSK	3.10e-05	6	43	2	EFO_0021046
Disease	1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6) measurement	PDXDC1 MUSK	3.10e-05	6	43	2	EFO_0800390
Disease	1-stearoyl-2-dihomo-linolenoyl-GPC (18:0/20:3n3 or 6) measurement	PDXDC1 MUSK	3.10e-05	6	43	2	EFO_0800434
Disease	very low density lipoprotein particle size measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	4.25e-05	133	43	4	EFO_0008594
Disease	fatty acid desaturase enzyme activity measurement	PDXDC1 MUSK	5.78e-05	8	43	2	EFO_0009791
Disease	idiopathic pulmonary fibrosis (is_implicated_in)	MUC5B HLA-DRB1	7.42e-05	9	43	2	DOID:0050156 (is_implicated_in)
Disease	level of Phosphatidylcholine (O-18:1_20:3) in blood serum	PDXDC1 MUSK	7.42e-05	9	43	2	OBA_2045130
Disease	1-stearoyl-2-arachidonoyl-GPC (18:0/20:4) measurement	PDXDC1 MUSK	7.42e-05	9	43	2	EFO_0800271
Disease	triglycerides to total lipids in small LDL percentage	PDXDC1 PLCB3 HLA-DRB1	8.85e-05	59	43	3	EFO_0022337
Disease	level of Phosphatidylcholine (16:0_20:3) in blood serum	PDXDC1 MUSK	9.27e-05	10	43	2	OBA_2045075
Disease	free cholesterol measurement, high density lipoprotein cholesterol measurement	PDXDC1 OBSL1 PLCB3 MUSK HLA-DRB1	9.27e-05	315	43	5	EFO_0004612, EFO_0008591
Disease	phospholipid measurement, high density lipoprotein cholesterol measurement	PDXDC1 OBSL1 PLCB3 MUSK HLA-DRB1	1.01e-04	321	43	5	EFO_0004612, EFO_0004639
Disease	high density lipoprotein particle size measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	1.10e-04	170	43	4	EFO_0008592
Disease	lipid measurement, high density lipoprotein cholesterol measurement	PDXDC1 OBSL1 PLCB3 MUSK HLA-DRB1	1.15e-04	330	43	5	EFO_0004529, EFO_0004612
Disease	triglycerides to phosphoglycerides ratio	PDXDC1 PLCB3 HLA-DRB1	1.35e-04	68	43	3	EFO_0022327
Disease	ovarian cancer (is_marker_for)	TNFRSF1A ANGPT1 EFEMP2	1.35e-04	68	43	3	DOID:2394 (is_marker_for)
Disease	level of Phosphatidylinositol (16:0_18:1) in blood serum	PDXDC1 MUSK	1.36e-04	12	43	2	OBA_2045152
Disease	level of Phosphatidylcholine (O-16:0_20:3) in blood serum	PDXDC1 MUSK	1.36e-04	12	43	2	OBA_2045115
Disease	level of Phosphatidylinositol (18:0_20:3) in blood serum	PDXDC1 MUSK	1.36e-04	12	43	2	OBA_2045157
Disease	temporal arteritis	RSBN1 HLA-DRB1	1.36e-04	12	43	2	EFO_1001209
Disease	uveitis (is_implicated_in)	TNFRSF1A HLA-DRB1	1.60e-04	13	43	2	DOID:13141 (is_implicated_in)
Disease	phosphatidylcholine 40:7 measurement	PDXDC1 MUSK	1.60e-04	13	43	2	EFO_0021477
Disease	triglycerides to total lipids in small HDL percentage	PDXDC1 PLCB3 HLA-DRB1	1.60e-04	72	43	3	EFO_0022336
Disease	phospholipids in large HDL measurement	PDXDC1 MUSK HLA-DRB1	1.67e-04	73	43	3	EFO_0022190
Disease	1-stearoyl-2-dihomo-linolenoyl-GPI (18:0/20:3n3 or 6) measurement	PDXDC1 MUSK	1.87e-04	14	43	2	EFO_0022085
Disease	monounsaturated fatty acids; 16:1, 18:1 measurement	PDXDC1 MUSK HLA-DRB1	2.03e-04	78	43	3	EFO_0022187
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	PDXDC1 PLCB3 MUSK HLA-DRB1	2.06e-04	200	43	4	EFO_0004611, EFO_0020945
Disease	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	2.30e-04	206	43	4	EFO_0004612, EFO_0020947
Disease	level of Phosphatidylcholine (18:0_20:3) in blood serum	PDXDC1 MUSK	2.46e-04	16	43	2	OBA_2045093
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	PDXDC1 MUSK HLA-DRB1	2.71e-04	86	43	3	EFO_0008595, EFO_0020945
Disease	Seizures	TRIM8 NTNG2 ZNF142 REST	2.85e-04	218	43	4	C0036572
Disease	level of Phosphatidylcholine (15:0_18:2) in blood serum	PDXDC1 MUSK	3.13e-04	18	43	2	OBA_2045065
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	3.16e-04	224	43	4	EFO_0004530, EFO_0008317
Disease	total cholesterol measurement, very low density lipoprotein cholesterol measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	3.16e-04	224	43	4	EFO_0004574, EFO_0008317
Disease	chylomicron measurement, triglyceride measurement, very low density lipoprotein cholesterol measurement	PDXDC1 PLCB3 HLA-DRB1	3.75e-04	96	43	3	EFO_0004530, EFO_0008317, EFO_0008596
Disease	level of Phosphatidylcholine (16:0_18:2) in blood serum	PDXDC1 MUSK	3.88e-04	20	43	2	OBA_2045071
Disease	very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	PDXDC1 PLCB3 MUSK HLA-DRB1	4.04e-04	239	43	4	EFO_0008317, EFO_0020945
Disease	fatty acid measurement	PDXDC1 PLCB3 IGLON5 MUSK HLA-DRB1	4.17e-04	436	43	5	EFO_0005110
Disease	Immunosuppressant use measurement	RSBN1 HLA-DRB1	4.28e-04	21	43	2	EFO_0009934
Disease	Vitiligo	PLCB3 MUSK HLA-DRB1	4.35e-04	101	43	3	EFO_0004208
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipid measurement	PDXDC1 PLCB3 HLA-DRB1	5.43e-04	109	43	3	EFO_0004639, EFO_0008317, EFO_0008596
Disease	Myasthenic Syndromes, Congenital	LAMB2 MUSK	5.61e-04	24	43	2	C0751882
Disease	lymphoma	HLA-DRB1 ZFP91	5.61e-04	24	43	2	EFO_0000574
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	PDXDC1 PLCB3 MUSK HLA-DRB1	5.88e-04	264	43	4	EFO_0008317, EFO_0020944
Disease	alpha-linolenic acid measurement	PDXDC1 MUSK	6.09e-04	25	43	2	EFO_0007759
Disease	omega-3 polyunsaturated fatty acid measurement	PDXDC1 MUSK HLA-DRB1	6.85e-04	118	43	3	EFO_0010119
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	6.94e-04	276	43	4	EFO_0004612, EFO_0020943
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	PDXDC1 PLCB3 HLA-DRB1	7.36e-04	121	43	3	EFO_0008595, EFO_0020943
Disease	phosphatidylcholine 38:4 measurement	PDXDC1 MUSK	7.65e-04	28	43	2	EFO_0010386
Disease	level of Phosphatidylethanolamine (18:0_18:2) in blood serum	PDXDC1 MUSK	7.65e-04	28	43	2	OBA_2045139
Disease	Autosomal dominant nonsyndromic hearing loss	REST TECTA	8.21e-04	29	43	2	cv:C5779548
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	PDXDC1 PLCB3 HLA-DRB1	8.47e-04	127	43	3	EFO_0008595, EFO_0020947
Disease	level of Sterol ester (27:1/20:4) in blood serum	PDXDC1 MUSK	9.39e-04	31	43	2	OBA_2045198
Disease	Global developmental delay	TRIM8 NTNG2 ZNF142	9.68e-04	133	43	3	C0557874
Disease	free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	9.81e-04	303	43	4	EFO_0004612, EFO_0020945
Disease	phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	1.03e-03	307	43	4	EFO_0004612, EFO_0020946
Disease	phosphatidylcholine 38:5 measurement	PDXDC1 MUSK	1.06e-03	33	43	2	EFO_0010387
Disease	sensorineural hearing loss (is_implicated_in)	TECTA HLA-DRB1	1.06e-03	33	43	2	DOID:10003 (is_implicated_in)
Disease	cholesteryl ester measurement, high density lipoprotein cholesterol measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	1.09e-03	312	43	4	EFO_0004612, EFO_0010351
Disease	left ventricular mass index	PDXDC1 REST	1.13e-03	34	43	2	EFO_0009290
Disease	total cholesterol measurement, high density lipoprotein cholesterol measurement	PDXDC1 PLCB3 MUSK HLA-DRB1	1.13e-03	315	43	4	EFO_0004574, EFO_0004612
Disease	cholesteryl ester 16:0 measurement	NTNG2 MUSK	1.27e-03	36	43	2	EFO_0010341
Disease	triglyceride measurement, phospholipid measurement	PDXDC1 PLCB3 HLA-DRB1	1.27e-03	146	43	3	EFO_0004530, EFO_0004639
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	PDXDC1 PLCB3 HLA-DRB1	1.37e-03	150	43	3	EFO_0004611, EFO_0020947

Protein segments in the cluster

Peptide	Gene	Start	Entry
YCNINEVCHYARRND	COL4A6	1526	Q14031
AERYAAACGVNYIHQ	ANKRD30B	241	Q9BXX2
RRYNRIQHGQCAYTF	ANGPT1	31	Q15389
CHDAQAVCRVYRYGQ	RAD54L2	841	Q9Y4B4
YRCECNVGYTQDVRG	FBN3	431	Q75N90
AYCQVRYLCSHLRGN	BICDL1	371	Q6ZP65
CFNYEIRVFCCNYGH	MUC5B	2956	Q9HC84
CFNYEIRVFCCNYGH	MUC5B	3656	Q9HC84
YYCDHQRGQKCVEFS	R3HDM1	856	Q15032
VYVCRARNAAGEAYA	OBSL1	81	O75147
IRCDRCGYNTNRYDH	REST	216	Q13127
CQYVYLHQCVRDVLR	PTPRB	1951	P23467
YRCHCQAGYSGRNCE	NOTCH1	891	P46531
ACAYQCHNLQGSYRC	HMCN2	4766	Q8NDA2
CVHNYQPCVQRAEGY	ERAP1	736	Q9NZ08
CRIFRYENGCAYFHE	PDXDC1	126	Q6P996
CRIFRYENGCAYFHE	PDXDC2P	126	Q6P474
DEYSQQIVCHCRAGY	LAMB2	946	P55268
IRSGYHYVCLRNEAN	PLCB3	816	Q01970
VSARHYGNYTCRAAN	IGLON5	281	A6NGN9
GYRRDVHQVACYSCT	KLHL22	506	Q53GT1
CARATVDHNYYAVCQ	DIPK2A	351	Q8NDZ4
RAAVDTYCRHNYGVV	HLA-DRB1	101	P01911
YRGRDCRNNVHYLND	EML5	1371	Q05BV3
DECRYRYCQHRCVNL	EFEMP2	166	O95967
RGQHCQHCRLGYYRN	NTNG2	381	Q96CW9
ENVYSYACQNHICRN	RTP3	196	Q9BQQ7
FHTQVNRTYCCGTYR	RSBN1	456	Q5VWQ0
GCCYRVNNSLDHEYQ	PLAAT4	71	Q9UL19
RGVAVHFAVCYRCAQ	PPP1R3G	321	B7ZBB8
YLCRVSINGYDHFCQ	RNF216	701	Q9NWF9
CHGVVNVTAYYRTCL	TECTA	926	O75443
YQCHQCGNAFRRKSY	ZNF567	281	Q8N184
CQNCYYNLQHERGSE	WDFY3	3506	Q8IZQ1
CYRNGVCYHQRPDEN	TMEM190	61	Q8WZ59
YCRRFCQVVEDYAGR	ZNF654	56	Q8IZM8
LMCCGRGYNTHQYAR	WNT7A	306	O00755
QLRNYCHSCNRVGYF	XKR3	436	Q5GH77
HTDQRDYICEYCARA	ZFP91	366	Q96JP5
GDLRYQCNQCSYRCH	ZNF142	481	P52746
YVLTVNERGNHCEYC	SMYD2	41	Q9NRG4
YRLYHCEAEQVAVCQ	TRIM8	151	Q9BZR9
RDTVCGCRKNQYRHY	TNFRSF1A	121	P19438
CRQCVEAYQDYDHHA	NALF1	261	B1AL88
YCAQYRGEVCNAVLA	MUSK	316	O15146