Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cellular response to insulin stimulus	ERFE HDAC5 INHBB SGK1 PRKAA1 PID1 PHIP	3.37e-05	271	69	7	GO:0032869
GeneOntologyBiologicalProcess	response to caffeine	PRKAA1 SELENON RYR1	4.56e-05	21	69	3	GO:0031000
HumanPheno	Cervical spinal canal stenosis	ARSL TRPM3 EXTL3	2.13e-05	11	27	3	HP:0008445
HumanPheno	Cervical vertebral dysplasia	ARSL POLR3A	2.71e-05	2	27	2	HP:0008469
HumanPheno	Abnormality of lower limb joint	POMT2 TGFBR1 ARSL TRPM3 SLC16A2 SCARF2 ZPR1 PITX1 LAMA5 EXTL3 ERI1 SELENON PHIP RYR1 POLR3A	5.01e-05	1027	27	15	HP:0100491
HumanPheno	Abnormal larynx morphology	ARSL SCARF2 SBF2 EXTL3 PHIP POLR3A CAPN15	6.08e-05	201	27	7	HP:0025423
HumanPheno	Type 1 and type 2 muscle fiber minicore regions	SELENON RYR1	8.09e-05	3	27	2	HP:0003787
HumanPheno	Talipes equinovarus	TGFBR1 TRPM3 SCARF2 SBF2 PITX1 LAMA5 SELENON RYR1 POLR3A	1.33e-04	399	27	9	HP:0001762
HumanPheno	Thin ribs	SCARF2 LAMA5 RYR1 POLR3A	1.42e-04	52	27	4	HP:0000883
HumanPheno	Abnormal synovial membrane morphology	POMT2 TRPM3 SCARF2 LAMA5 EXTL3 ERI1 SELENON PHIP RYR1 POLR3A	1.44e-04	503	27	10	HP:0005262
Domain	DEK_C	SSH1 SSH2	7.80e-05	4	68	2	IPR014876
Domain	DEK_C	SSH1 SSH2	7.80e-05	4	68	2	PF08766
Domain	MIR	POMT2 RYR1	5.77e-04	10	68	2	PS50919
Domain	MIR	POMT2 RYR1	5.77e-04	10	68	2	PF02815
Domain	MIR	POMT2 RYR1	5.77e-04	10	68	2	SM00472
Domain	MIR_motif	POMT2 RYR1	5.77e-04	10	68	2	IPR016093
Domain	Prot-tyrosine_phosphatase-like	SSH1 SBF2 SSH2	5.64e-03	99	68	3	IPR029021
Domain	DUSP	SSH1 SSH2	5.67e-03	31	68	2	IPR024950
Domain	TYR_PHOSPHATASE_DUAL	SSH1 SSH2	6.80e-03	34	68	2	PS50054
Domain	TYR_PHOSPHATASE_DUAL_dom	SSH1 SSH2	7.19e-03	35	68	2	IPR020422
Domain	Laminin_EGF	SCARF2 LAMA5	7.19e-03	35	68	2	PF00053
Domain	EGF_Lam	SCARF2 LAMA5	7.19e-03	35	68	2	SM00180
Domain	DSPc	SSH1 SSH2	7.19e-03	35	68	2	SM00195
Domain	ConA-like_dom	LAMA5 MDGA1 NEURL4 RYR1	8.34e-03	219	68	4	IPR013320
Domain	Laminin_EGF	SCARF2 LAMA5	8.44e-03	38	68	2	IPR002049
Domain	Ser/Thr_kinase_AS	TGFBR1 ERN1 SGK1 PRKAA1 TTK	9.67e-03	357	68	5	IPR008271
Domain	Dual-sp_phosphatase_cat-dom	SSH1 SSH2	9.77e-03	41	68	2	IPR000340
Domain	DSPc	SSH1 SSH2	9.77e-03	41	68	2	PF00782
Domain	S_TKc	TGFBR1 ERN1 SGK1 PRKAA1 TTK	9.89e-03	359	68	5	SM00220
Domain	PROTEIN_KINASE_ST	TGFBR1 ERN1 SGK1 PRKAA1 TTK	1.02e-02	362	68	5	PS00108
Pubmed	Multiminicore Disease – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	SELENON RYR1	3.99e-06	2	70	2	20301467
Pubmed	Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle.	SELENON RYR1	3.99e-06	2	70	2	18713863
Pubmed	Inositol-Requiring Enzyme 1-Dependent Activation of AMPK Promotes Brucella abortus Intracellular Growth.	ERN1 PRKAA1	3.99e-06	2	70	2	26755628
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	EDC3 HDAC5 UBR5 SBF2 GPN1 PITX1 PPIL4 NCBP1 SSH2 ERI1 TYSND1	6.87e-06	1038	70	11	26673895
Pubmed	Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.	SSH1 SSH2	1.20e-05	3	70	2	14531860
Pubmed	The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK.	PRKAA1 AFDN	1.20e-05	3	70	2	24385485
Pubmed	Structure and chromosomal localization of mouse G protein subunit gamma 4 gene.	LAMA5 GNG4	2.39e-05	4	70	2	9570961
Pubmed	The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.	SSH1 SSH2	2.39e-05	4	70	2	17848544
Pubmed	AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5.	HDAC5 PRKAA1	2.39e-05	4	70	2	23926128
Pubmed	The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes.	HDAC5 PRKAA1	3.98e-05	5	70	2	22462548
Pubmed	Primary Ciliary Dyskinesia Associated Disease-Causing Variants in CCDC39 and CCDC40 Cause Axonemal Absence of Inner Dynein Arm Heavy Chains DNAH1, DNAH6, and DNAH7.	DNAH7 CCDC40	3.98e-05	5	70	2	39056782
Pubmed	Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability.	SSH1 SSH2	3.98e-05	5	70	2	20477815
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	EDC3 UBR5 GPN1 AFDN TMEM131 TTK DNAH7 NEURL4 CLCC1	5.25e-05	853	70	9	28718761
Pubmed	Congenital Fiber-Type Disproportion – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	SELENON RYR1	5.96e-05	6	70	2	20301436
Pubmed	Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin.	SSH1 SSH2	5.96e-05	6	70	2	11832213
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	ZC3H14 ZPR1 GPN1 AFDN POLR3A	7.52e-05	215	70	5	35973513
Pubmed	Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.	SSH1 SSH2	1.42e-04	9	70	2	15660133
Pubmed	Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations.	SSH1 SSH2	1.42e-04	9	70	2	27588418
Pubmed	Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma.	TGFBR1 UBR5	1.42e-04	9	70	2	30836988
Pubmed	Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.	SELENON RYR1	1.42e-04	9	70	2	21858002
Pubmed	Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts.	ZC3H14 NCBP1	1.78e-04	10	70	2	27871484
Pubmed	NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling.	TGFBR1 SGK1	1.78e-04	10	70	2	17314099
Pubmed	Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate.	TGFBR1 INHBB	2.17e-04	11	70	2	21852401
Pubmed	Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.	TGFBR1 INHBB	2.60e-04	12	70	2	23342175
Pubmed	Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape.	TGFBR1 PITX1	3.07e-04	13	70	2	38509075
Pubmed	Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins.	UBR5 PITX1	3.58e-04	14	70	2	28511701
Pubmed	A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.	ZPR1 GPN1	4.12e-04	15	70	2	21386085
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ZC3H14 LAMA5 NCBP1 POLDIP2 NEURL4	4.29e-04	313	70	5	38270169
Pubmed	Congenital Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	POMT2 SELENON	5.33e-04	17	70	2	20301468
Pubmed	Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity.	TGFBR1 PITX1	6.68e-04	19	70	2	27453501
Pubmed	Large neutral amino acid levels tune perinatal neuronal excitability and survival.	ERN1 PRKAA1	8.18e-04	21	70	2	36996814
Pubmed	Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling.	PRKAA1 RYR1	8.99e-04	22	70	2	35081489
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ZC3H14 UBR5 RBM12B PRKAA1 AFDN NCBP1 NEURL4 PHIP	1.03e-03	1024	70	8	24711643
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TRPM3 ROBO2 CCDC40	1.13e-03	101	70	3	10997877
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	GTF2E1 UBR5 GPN1 NCBP1 POLR3A	1.15e-03	390	70	5	17643375
Pubmed	Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.	HDAC5 PRKAA1 BLNK SELENON	1.23e-03	231	70	4	21048031
Pubmed	Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis.	TGFBR1 PITX1	1.26e-03	26	70	2	33328221
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	HDAC5 LAMA5 EXTL3	1.26e-03	105	70	3	9628581
Pubmed	Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5.	TRPM3 RYR1	1.57e-03	29	70	2	29543863
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	EDC3 HDAC5 TTK POLR3A	1.67e-03	251	70	4	29778605
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	ZC3H14 UBR5 LAMA5 NCBP1	1.67e-03	251	70	4	28077445
Pubmed	A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation.	TGFBR1 PITX1	1.67e-03	30	70	2	32597756
Pubmed	Maternal diabetes alters transcriptional programs in the developing embryo.	TGFBR1 PHIP	1.90e-03	32	70	2	19538749
Cytoband	3p12.3	ROBO2 FRG2C	3.45e-04	18	70	2	3p12.3
Cytoband	Ensembl 112 genes in cytogenetic band chr6q14	HTR1E TTK PHIP	4.52e-04	97	70	3	chr6q14
GeneFamily	Slingshot protein phosphatases	SSH1 SSH2	1.90e-05	3	46	2	898
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Neuron\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	GTPBP8 SSH1 INHBB SCARF2 TMEM131 SSH2	3.39e-07	175	70	6	2812ac2ef41d245db544697fb6da1883361c96e8
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TGFBR1 GSDME ASPHD1 SLC16A2 EGR4 SGK1	4.70e-07	185	70	6	274b8acccdfe434d14af4cb32fb615c06ec98435
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TGFBR1 GSDME ASPHD1 SLC16A2 EGR4 SGK1	4.70e-07	185	70	6	b640d9ed6a1e6aa595053065bb992efc0402353e
ToppCell	Control-Myeloid-MoAM4\|Control / Disease group,lineage and cell class （2021.01.30）	TGFBR1 GSDME ASPHD1 SLC16A2 EGR4 SGK1	5.84e-07	192	70	6	1da7c303a2e36af4a9d8ec30a11380d9b1897922
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GSDME ASPHD1 SLC16A2 EGR4 SGK1	1.09e-05	185	70	5	29d7ddcb9a2e45f76cd5611f7c52b6df689effd3
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GSDME ASPHD1 SLC16A2 EGR4 SGK1	1.09e-05	185	70	5	780bdb63ef913a09930063286011c9108381d3a9
Disease	Congenital muscular dystrophy	POMT2 SELENON RYR1	2.43e-06	12	67	3	cv:C0699743
Disease	Multiminicore myopathy	SELENON RYR1	5.08e-06	2	67	2	cv:C0270962
Disease	Rare disease with malignant hyperthermia	SELENON RYR1	3.04e-05	4	67	2	cv:C5681128
Disease	Congenital myopathy with fiber type disproportion	SELENON RYR1	7.57e-05	6	67	2	cv:C0546264
Disease	triglyceride measurement, metabolic syndrome	ZPR1 GPN1	1.41e-04	8	67	2	EFO_0000195, EFO_0004530
Disease	Congenital myopathy (disorder)	SELENON RYR1	3.30e-04	12	67	2	C0270960
Disease	Autosomal Dominant Myotubular Myopathy	SELENON RYR1	3.90e-04	13	67	2	C3661489
Disease	Centronuclear myopathy	SELENON RYR1	3.90e-04	13	67	2	C0175709
Disease	X-linked centronuclear myopathy	SELENON RYR1	3.90e-04	13	67	2	C0410203
Disease	Congenital Structural Myopathy	SELENON RYR1	3.90e-04	13	67	2	C0752282
Disease	Myopathy, Centronuclear, 1	SELENON RYR1	3.90e-04	13	67	2	C4551952
Disease	Myopathy, Centronuclear, Autosomal Dominant	SELENON RYR1	4.54e-04	14	67	2	C1834558
Disease	Tubular Aggregate Myopathy	SELENON RYR1	4.54e-04	14	67	2	C0410207
Disease	Autosomal Recessive Centronuclear Myopathy	SELENON RYR1	5.23e-04	15	67	2	C3645536
Disease	Uremia	TGFBR1 SGK1	6.76e-04	17	67	2	C0041948
Disease	Congenital Fiber Type Disproportion	SELENON RYR1	7.59e-04	18	67	2	C0546264
Disease	triacylglycerol 50:4 measurement	MGMT ZPR1	2.12e-03	30	67	2	EFO_0010411

Protein segments in the cluster

Peptide	Gene	Start	Entry
PHAQEEAEAEAELPP	PI16	351	Q6UXB8
HCAPDEPFIPTDLIE	AFDN	886	P55196
EGNPPEFVHEIIEFP	ERI1	141	Q8IV48
RVVSAEEEAHPSPPD	EXOC3L4	216	Q17RC7
ASLVLPEEPVHFRPI	CFAP61	366	Q8NHU2
LAKDPPHARSEDVPD	C1orf140	76	Q5VVS0
VHHDPPLLFDLSRDP	ARSL	506	P51690
LLERNFHPFAELPEP	GSDME	291	O60443
ASIRIPPFDNDLDHP	HTR1E	261	P28566
PAPLPELEFESERVH	SLC16A2	61	P36021
RPPEEDFRHSPEEDF	RBM12B	701	Q8IXT5
INHTVILDDPFDDPP	PPIL4	156	Q8WUA2
EVVAPAGFHVVPAAP	CAPN15	186	O75808
PVVPAAAEAPDHAEL	MDGA1	586	Q8NFP4
FERPDGSHFDVRIPP	POLDIP2	336	Q9Y2S7
FAELFQLPAPPHIDV	NCBP1	356	Q09161
LAAVHSPPADDVPAE	FSCB	696	Q5H9T9
ILHPDLEVADHAFPP	SBF2	326	Q86WG5
REHSDAVPDAPILPV	NCR3LG1	411	Q68D85
PSAPFVPRDAQRHDV	ASPHD1	196	Q5U4P2
VPVFVDPGEESHRPF	INHBB	261	P09529
HQPEAIEEFPVPALH	MGMT	71	P16455
EPLPAVIFHEPEAIE	PID1	61	Q7Z2X4
PEPTAERAHSVDPRD	ERFE	66	Q4G0M1
EAHVREDPLIIPVPA	GNG4	46	P50150
RAPVLSIDPPVHEVE	EDC3	436	Q96F86
IQAVPEHPHDPEALF	EGR4	191	Q05215
ADLRHVPEAVPEAFP	LAMA5	1676	O15230
RIDHAPDLPRPEVCF	GTPBP8	101	Q8N3Z3
DPAVHEVPFPANIDI	GPN1	56	Q9HCN4
REPHHLADPDTPVFE	PKD1L2	1421	Q7Z442
EPRFPELAALADPHA	FJX1	396	Q86VR8
DPVLHPSEERAAPVL	FAM189A2	276	Q15884
DREAHPFPGQEITEP	FRG2C	256	A6NGY1
PPDPHARARVDEFVA	GSTT4	86	A0A1W2PR19
VEQETRPVHPALPFA	BLNK	101	Q8WV28
DVEEKPAHAPARPEA	ERN1	421	O75460
PAAPIREEAAAEIPH	EXTL3	541	O43909
VPDAHPREGDLPVFQ	CCDC40	231	Q4G0X9
LIAQPPDSVRAFEHP	DNAH7	386	Q8WXX0
AAAAREHSPRPAEEP	HDAC5	1101	Q9UQL6
ALIAPDHVVPAPEEC	SLC38A9	81	Q8NBW4
PHDVVPADNRDDPEI	RYR1	1411	P21817
APAAQAEPERLLFHP	NEURL4	511	Q96JN8
AFEVELPENELLHPP	FER1L6	1046	Q2WGJ9
FHLARPADPREPLEN	PITX1	31	P78337
PPRPAAVAVHKREED	GTF2E1	366	P29083
PLDPSFPVEFVRHGD	POMT2	396	Q9UKY4
DLRHFDPEFTEEPVP	SGK1	381	O00141
PDPNLRIDEVAVPVH	POLR3A	371	O14802
PVRVEDEPRAFSPEH	SHISA9	326	B4DS77
VAVAAAPEPLIPFHQ	SH3TC1	266	Q8TE82
REPEPFVLHHDQTPE	TEX45	296	Q8NA69
HRVPNEEDPSLDRPF	TGFBR1	156	P36897
LEEAAPPAEVHRPAR	SSH1	541	Q8WYL5
HPERVPFLVAETPRA	PRKAA1	371	Q13131
DVPDAEAREHPTVVP	CLCC1	446	Q96S66
PAPDHLFRPISAEDE	ZPR1	26	O75312
DPIAHPRHEADEKPF	ZNF691	101	Q5VV52
EDEVFVLEPHPFDPR	PHIP	466	Q8WWQ0
VLEPHPFDPRVLFSA	PHIP	471	Q8WWQ0
APRVLEFDHLPDPQE	SSH2	956	Q76I76
DIDLDDPEINHFPFP	TRPM3	646	Q9HCF6
VPHEEAPAESRDPEV	SCARF2	566	Q96GP6
RIHAEFQLSEPPDFP	SELENON	291	Q9NZV5
LFHIRDSPADPVERP	TMEM131	441	Q92545
RAHAVAEPAVPAGEP	ZNF775	386	Q96BV0
QEDFPPRIVEHPSDV	ROBO2	26	Q9HCK4
PVVVLNHPDADAPEV	ZNF518A	1346	Q6AHZ1
AIIDPNHEIEFPDIP	TTK	746	P33981
PRPIFDLEFHLLEPV	PRR23C	211	Q6ZRP0
DERRHEAAVPPLAIP	ZC3H14	106	Q6PJT7
EDLDDVPIPVPAEHF	TYSND1	416	Q2T9J0
EVPLAEAIPLADQPH	UBR5	2041	O95071