Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	decreased circulating chemokine level	SNX8 ZCCHC3	1.01e-05	2	45	2	MP:0014496
MousePheno	decreased circulating CXCL10 level	SNX8 ZCCHC3	1.01e-05	2	45	2	MP:0031219
MousePheno	decreased CXCL10 level	SNX8 ZCCHC3	1.01e-05	2	45	2	MP:0031225
MousePheno	decreased chemokine level	SNX8 ZCCHC3	1.01e-05	2	45	2	MP:0014432
MousePheno	abnormal circulating CXCL10 level	SNX8 ZCCHC3	1.01e-04	5	45	2	MP:0031218
MousePheno	abnormal CXCL10 level	SNX8 ZCCHC3	2.11e-04	7	45	2	MP:0031224
Domain	Homeobox_KN	TGIF2LY TGIF2LX	1.34e-03	17	60	2	PF05920
Domain	Homeobox_KN_domain	TGIF2LY TGIF2LX	1.34e-03	17	60	2	IPR008422
Domain	-	SMARCA5 TGIF2LY VRTN TGIF2LX LHX6	2.13e-03	283	60	5	1.10.10.60
Domain	Znf_C2H2_jaz	ZNF385A ZNF784	2.25e-03	22	60	2	IPR022755
Domain	zf-C2H2_jaz	ZNF385A ZNF784	2.25e-03	22	60	2	PF12171
Domain	ADAM_spacer1	ADAMTS9 ADAMTS16	2.46e-03	23	60	2	IPR010294
Domain	ADAM_spacer1	ADAMTS9 ADAMTS16	2.46e-03	23	60	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS9 ADAMTS16	2.68e-03	24	60	2	IPR013273
Domain	PROTEIN_KINASE_TYR	IGF1R AATK TP53RK	3.75e-03	97	60	3	PS00109
Domain	Tyr_kinase_AS	IGF1R AATK TP53RK	3.75e-03	97	60	3	IPR008266
Domain	Homeodomain-like	SMARCA5 TGIF2LY VRTN TGIF2LX LHX6	4.23e-03	332	60	5	IPR009057
Domain	Cadherin_tail	PCDHGB5 PCDHGB1	6.29e-03	37	60	2	PF15974
Domain	Cadherin_CBD	PCDHGB5 PCDHGB1	6.29e-03	37	60	2	IPR031904
Domain	Peptidase_M12B_N	ADAMTS9 ADAMTS16	6.97e-03	39	60	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS9 ADAMTS16	6.97e-03	39	60	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS9 ADAMTS16	7.32e-03	40	60	2	PS00427
Domain	Reprolysin	ADAMTS9 ADAMTS16	7.32e-03	40	60	2	PF01421
Domain	ADAM_MEPRO	ADAMTS9 ADAMTS16	7.32e-03	40	60	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS9 ADAMTS16	7.32e-03	40	60	2	PS50214
Domain	Peptidase_M12B	ADAMTS9 ADAMTS16	7.32e-03	40	60	2	IPR001590
Domain	CYSTEINE_SWITCH	ADAMTS9 ADAMTS16	7.68e-03	41	60	2	PS00546
Domain	Disintegrin_dom	ADAMTS9 ADAMTS16	7.68e-03	41	60	2	IPR001762
Domain	Cadherin_C	PCDHGB5 PCDHGB1	8.05e-03	42	60	2	IPR032455
Domain	Cadherin_C_2	PCDHGB5 PCDHGB1	8.05e-03	42	60	2	PF16492
Domain	Pept_M10_metallopeptidase	ADAMTS9 ADAMTS16	8.42e-03	43	60	2	IPR001818
Pubmed	Expression of a novel TGIF subclass homeobox gene, Tex1, in the spermatids of mouse testis during spermatogenesis.	TGIF2LY TGIF2LX	3.13e-06	2	62	2	11960710
Pubmed	Association of TGIFLX/Y mRNA expression with prostate cancer.	TGIF2LY TGIF2LX	3.13e-06	2	62	2	18663611
Pubmed	The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon.	TGIF2LY TGIF2LX	3.13e-06	2	62	2	12226713
Pubmed	Association of TGIFLX/Y mRNA expression with azoospermia in infertile men.	TGIF2LY TGIF2LX	3.13e-06	2	62	2	18384077
Pubmed	PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility.	IGF1R PSPC1	3.13e-06	2	62	2	32570949
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SMARCA5 SFSWAP RTCB NCL TOE1 SYMPK	5.83e-06	251	62	6	31076518
Pubmed	Upon intracellular processing, the C-terminal death domain-containing fragment of the p53-inducible PIDD/LRDD protein translocates to the nucleoli and interacts with nucleolin.	PIDD1 NCL	9.37e-06	3	62	2	16982033
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	SMARCA5 SFSWAP RTCB PSMA5 EHMT1 NCL PSPC1 TOE1 SYMPK	1.85e-05	847	62	9	35850772
Pubmed	Molecular cloning of a mouse scavenger receptor with C-type lectin (SRCL)(1), a novel member of the scavenger receptor family.	TGIF2LY TGIF2LX	1.87e-05	4	62	2	11718900
Pubmed	Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.	ADAMTS9 ADAMTS16	1.87e-05	4	62	2	16507336
Pubmed	Expression pattern of TG-interacting factor 2 during mouse development.	TGIF2LY TGIF2LX	3.12e-05	5	62	2	15749073
Pubmed	Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells.	ADAMTS9 ADAMTS16	3.12e-05	5	62	2	22562232
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	SFSWAP RTCB PSMA5 EHMT1 NCL CDC20 PSPC1 SAP30 SYMPK	3.58e-05	922	62	9	27609421
Pubmed	ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2.	RTCB PSPC1 ZCCHC3	4.35e-05	38	62	3	30629181
Pubmed	Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11-q13 syndromes by fine-structure homology mapping in the mouse.	MKRN3 IGF1R	4.67e-05	6	62	2	8095339
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SMARCA5 SFSWAP RTCB EHMT1 NCL PSPC1 PGRMC1 TOE1 SYMPK	1.22e-04	1082	62	9	38697112
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SMARCA5 RTCB PLEKHG3 MYO19 PSMA5 NCL TP53RK CDC20 CORO7 TOE1	1.31e-04	1353	62	10	29467282
Pubmed	Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development.	IGF1R TNNI3	1.39e-04	10	62	2	36139407
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	IGF1R AATK MEGF8 SNX8 EHMT1 DENND5A SSBP4 SAP30 SYMPK	1.43e-04	1105	62	9	35748872
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	FNTA RTCB NCL ZNF385A PSPC1 TOE1 ZCCHC3	2.53e-04	704	62	7	32994395
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGB5 PCDHGB1	3.23e-04	15	62	2	23515096
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	FNTA RTCB PSMA5 NAP1L5 SNX8 NCL CORO7 PGRMC1	3.26e-04	974	62	8	28675297
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	SMARCA5 SFSWAP RTCB PSMA5 NCL CDC20 TOE1 SYMPK	3.61e-04	989	62	8	36424410
Pubmed	Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.	SMARCA5 EHMT1	3.69e-04	16	62	2	28803780
Pubmed	ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.	ADAMTS9 ADAMTS16	3.69e-04	16	62	2	30579834
Pubmed	Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus.	MKRN3 IGF1R	3.69e-04	16	62	2	8601494
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	SMARCA5 RTCB PLEKHG3 NCL CDC20 PSPC1 F5 TOE1 ZCCHC3	3.70e-04	1257	62	9	36526897
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SMARCA5 SFSWAP PSMA5 NCL PGRMC1 SAP30 SYMPK	4.47e-04	774	62	7	15302935
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	SMARCA5 RTCB PLEKHG3 PSMA5 NCL PSPC1 F5 PGRMC1	4.55e-04	1024	62	8	24711643
Pubmed	The RNA ligase RNA terminal phosphate cyclase B regulates mRNA alternative splicing and is required for mouse oocyte development and maintenance.	RTCB CDC20	4.70e-04	18	62	2	36178098
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	SMARCA5 EHMT1 NCL	4.97e-04	86	62	3	37253089
Pubmed	Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.	SMARCA5 CDC20	5.82e-04	20	62	2	18162579
Pubmed	Proteomics analysis of the estrogen receptor alpha receptosome.	RTCB NCL PSPC1	6.24e-04	93	62	3	20348541
Pubmed	CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.	SMARCA5 IGF1R	6.42e-04	21	62	2	22154806
Pubmed	The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.	SMARCA5 RTCB NCL PGRMC1	6.52e-04	220	62	4	34091597
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	SMARCA5 RTCB PSPC1 SYMPK	6.52e-04	220	62	4	35785414
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	SMARCA5 RTCB PSMA5 CLPTM1 NCL TP53RK PSPC1 UBE2Z SYMPK	6.77e-04	1367	62	9	32687490
Pubmed	FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.	PSMA5 CLPTM1 PGRMC1 ZCCHC3	6.86e-04	223	62	4	34226595
Pubmed	Perioperative genomic profiles using structure-specific oligonucleotide probes.	F5 PRKY	7.72e-04	23	62	2	19474452
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	KCTD13 RTCB TP53RK PGRMC1 SYMPK	8.28e-04	410	62	5	25814554
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	SMARCA5 RTCB VRTN PSPC1 PGRMC1	8.37e-04	411	62	5	35182466
Pubmed	Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation.	IGF1R TNNI3	8.41e-04	24	62	2	37543677
Pubmed	Identification of transcripts with enriched expression in the developing and adult pancreas.	COL15A1 ADAMTS16 ZNF385A TNNI3 SYMPK KIF1C	8.54e-04	624	62	6	18554416
Pubmed	Human transcription factor protein interaction networks.	SMARCA5 RTCB PSMA5 EHMT1 SSBP4 LHX6 PGRMC1 ZCCHC3 SYMPK	9.27e-04	1429	62	9	35140242
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	CCDC43 PSMA5 NCL ZNF385A CDC20 SYMPK	9.65e-04	639	62	6	23443559
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	CLPTM1 NCL PGRMC1	1.10e-03	113	62	3	30352685
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHGB5 PCDHGB1	1.15e-03	28	62	2	15347688
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	RTCB PSPC1 ZCCHC3 KIF1C	1.18e-03	258	62	4	37794589
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	SMARCA5 EHMT1 SYMPK	1.18e-03	116	62	3	21549307
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	COL15A1 MYO19 PSMA5 NCL CDC20 ARMCX2 PSPC1 RTN1 ZCCHC3	1.28e-03	1496	62	9	32877691
Pubmed	Isolation and characterization of proteins associated with histone H3 tails in vivo.	EHMT1 NCL	1.32e-03	30	62	2	17403666
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	SMARCA5 KCTD13 RTCB PLEKHG3 NCL CDC20 TOE1	1.47e-03	949	62	7	36574265
Pubmed	Shotgun proteomics and network analysis of ubiquitin-related proteins from human breast carcinoma epithelial cells.	PSMA5 NCL	1.50e-03	32	62	2	21853274
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	EHMT1 ARMCX2 TOE1 SAP30 ZCCHC3	1.50e-03	469	62	5	27634302
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	CCDC43 SMARCA5 SFSWAP NCL CORO7 TOE1	1.55e-03	701	62	6	30196744
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	SMARCA5 RTCB EHMT1 TP53RK TOE1 SAP30	1.58e-03	704	62	6	29955894
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	SMARCA5 NCL DENND5A PSPC1	1.65e-03	283	62	4	30585729
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	SMARCA5 RTCB PSPC1	1.68e-03	131	62	3	34551306
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	SFSWAP RTCB NCL TOE1 ZCCHC3 SYMPK	1.69e-03	713	62	6	29802200
Pubmed	CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†.	TGIF2LY TGIF2LX	1.69e-03	34	62	2	31201419
Pubmed	Functional significance of isoform diversification in the protocadherin gamma gene cluster.	PCDHGB5 PCDHGB1	1.69e-03	34	62	2	22884324
Pubmed	A SOX17-PDGFB signaling axis regulates aortic root development.	COL15A1 TNNI3	1.69e-03	34	62	2	35831318
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	MEGF8 EID2 CLPTM1 CDC42EP5 TNNI3 ZNF784 LILRB5 SYMPK	1.97e-04	1192	62	8	chr19q13
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS9 ADAMTS16	6.82e-04	19	37	2	50
GeneFamily	TALE class homeoboxes and pseudogenes	TGIF2LY TGIF2LX	1.28e-03	26	37	2	526
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	IGF1R AATK	3.03e-03	40	37	2	321
GeneFamily	Clustered protocadherins	PCDHGB5 PCDHGB1	7.59e-03	64	37	2	20
Disease	keratoconus	PIDD1 STK35 KIF1C	3.02e-04	66	58	3	MONDO_0015486
Disease	hypertrophic cardiomyopathy (is_implicated_in)	CACNB2 TNNI3	8.55e-04	22	58	2	DOID:11984 (is_implicated_in)
Disease	mental development measurement	PCDHGB5 PCDHGB1	1.11e-03	25	58	2	EFO_0008230
Disease	apolipoprotein B measurement	CACNB2 PSMA5 CLPTM1 SNX8 TNNI3 SYMPK	1.89e-03	663	58	6	EFO_0004615
Disease	left ventricular mass index	CACNB2 IGF1R	2.05e-03	34	58	2	EFO_0009290
Disease	liver cirrhosis (is_implicated_in)	IGF1R F5	3.26e-03	43	58	2	DOID:5082 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLAVAAVMAAAAGSP	ZNF385A	331	Q96PM9
MSAEASGPAAAAAPS	KCTD13	1	Q8WZ19
MSPDGATVASAAADE	CDC20	451	Q12834
MAAAAGDADDEPRSG	ANKRD54	1	Q6NXT1
AAEAPAMAGAPKVAE	ARMCX2	151	Q7L311
VAEQAPACAMGPAAA	ADAMTS16	21	Q8TE57
SAAHEDDVPVPGMAI	CACNB2	126	Q08289
MAAPSEVAAIAPGEG	CCDC43	1	Q96MW1
AAAITGDSAEAMPAP	MYO19	721	Q96H55
TAAEADMDAAAGPPV	GARIN4	381	Q8IYT1
QPAVMETPVGDADAS	CORO7	411	P57737
VFARTMPAEGADDIP	IGF1R	821	P08069
DGSALFDMVPRAAEP	PCDHGB1	566	Q9Y5G3
MAAEDVVATGADPSD	PGRMC1	1	O00264
PPMEESVAHAVAAVG	MEGF8	1836	Q7Z7M0
SEAAEEAAPSDRMPS	KIF1C	896	O43896
EGTAPPAMAQSDAEA	LHX6	16	Q9UPM6
GVEMDAPAAASEAPQ	LILRB5	536	O75023
EDADPGAMSRPFGVA	PSMA5	126	P28066
DGSALFDMVPRAAEP	PCDHGB5	566	Q9Y5G0
EPAAMKAAAAAPASE	NCL	171	P19338
DLAEMGSPDAAAAVR	ADAMTS9	16	Q9P2N4
APPADDRDQSSMEDG	DENND5A	166	Q6IQ26
VMDAARPEAAAAKPD	CDC42EP5	106	Q6NZY7
PAQPEEAGEGAMAAA	EID2	36	Q8N6I1
TAAGEAEALASMPGE	COL15A1	411	P39059
AEALASMPGEVEASG	COL15A1	416	P39059
MAAADAEAVPARGEP	EHMT1	1	Q9H9B1
MAATVEGPELEAAAA	PIDD1	1	Q9HB75
AFDMNDPEAVVSPGG	RTCB	101	Q9Y3I0
VSEDPMAAEDALPSG	RTN1	416	Q16799
GGDSMQAVSAPEEAP	SFSWAP	511	Q12872
MEREPSASEAAPAAA	SERGEF	1	Q9UGK8
MEAAADGPAETQSPV	TGIF2LX	1	Q8IUE1
MQVPPEVSAEAGDAA	SIGLEC15	46	Q6ZMC9
MEAAADGPAETQSPV	TGIF2LY	1	Q8IUE0
MDPLPAAAVGAAAEA	SNX8	6	Q9Y5X2
PDEMSRGGDAAAAVA	SAP30	6	O75446
HTFPAEKMDDAVAPG	F5	131	P12259
AAFAMALDPAAPAPA	AATK	1311	Q6ZMQ8
PPGDMVDFVAAESTE	PLEKHG3	556	A1L390
MAAVAPAGPGDSASA	NIPAL2	1	Q9H841
AGDPDSAAGQMAEEP	NAP1L5	41	Q96NT1
AEAGEAVASPMDDGF	FNTA	41	P49354
MEAPGPAQAAAAESN	PRKY	1	O43930
NEFGMSGEDPTAAAP	CLPTM1	596	O96005
EAEALPSDESPVAMG	TEX44	206	Q53QW1
PSDESPVAMGANVVD	TEX44	211	Q53QW1
PAAAARAMDPVAAEA	STK35	166	Q8TDR2
RAMDPVAAEAPGEAF	STK35	171	Q8TDR2
AEAAAAAMATPARPG	ZCCHC3	126	Q9NUD5
AAMATPARPGEAEDA	ZCCHC3	131	Q9NUD5
MEEPAAPSEAHEAAG	MKRN3	1	Q13064
VGESEPAAAAAMALA	PSPC1	26	Q8WXF1
PAAAAAMALALAGEP	PSPC1	31	Q8WXF1
GVPAVSMDELAAFAD	ILDR2	421	Q71H61
NAPGTPRDDGEMAAA	SSBP4	351	Q9BWG4
MAESPTEEAATAGAG	UBE2Z	1	Q9H832
MAGPAAEAERVSSPA	PRR33	151	A8MZF0
GEDAMKTPSPAAEDA	SYMPK	1251	Q92797
MADGSSDAAREPRPA	TNNI3	1	P19429
MAAARATTPADGEEP	TP53RK	1	Q96S44
ASAASAGPADAEMEE	SMARCA5	46	O60264
AVMAPPVGASSEDVE	VRTN	586	Q9H8Y1
MAADSDDGAVSAPAA	TOE1	1	Q96GM8
MAAETRNVAGAEAPP	METTL1	1	Q9UBP6
PERAEVVMAAAAAGA	ZNF784	176	Q8NCA9