Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	fn3	DSCAM TNXB EPHA3	4.01e-03	162	37	3	PF00041
Domain	FN3	DSCAM TNXB EPHA3	5.80e-03	185	37	3	SM00060
Domain	FN3	DSCAM TNXB EPHA3	7.09e-03	199	37	3	PS50853
Domain	FN3_dom	DSCAM TNXB EPHA3	8.11e-03	209	37	3	IPR003961
Domain	Rho_GTPase_activation_prot	ARHGAP22 NF1	1.31e-02	88	37	2	IPR008936
Pubmed	A chondroplastic, brachymorphic and stubby chondrodystophies in mice.	NPR2 PAPSS2	1.16e-06	2	38	2	939824
Pubmed	IGF2/IGF2R/Sting signaling as a therapeutic target in DSS-induced ulcerative colitis.	STING1 IGF2R	1.16e-06	2	38	2	37863414
Pubmed	The growth of femur and tibia in three genetically distinct chondrodystrophic mutants of the house mouse.	NPR2 PAPSS2	1.16e-06	2	38	2	624676
Pubmed	Three recessive mutations producing disproportionate dwarfing in mice: achondroplasia, brachymorphic, and stubby.	NPR2 PAPSS2	6.96e-06	4	38	2	5713631
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	RIOX2 SMARCA1 RNF213 EEF2K NUP155	7.62e-06	250	38	5	33536335
Pubmed	Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia.	PAPSS2 EPHA3	1.56e-04	17	38	2	15944189
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	ZWILCH DSCAM	1.76e-04	18	38	2	25363768
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	RNF213 EEF2K IGF2R NUP155 DSCAM DNAH7	1.83e-04	777	38	6	35844135
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	DOCK3 PFAS ZFYVE26	2.03e-04	104	38	3	9205841
Pubmed	Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology.	FREM2 PFAS	2.41e-04	21	38	2	26234751
Pubmed	Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.	PFAS NUP155	3.43e-04	25	38	2	27621311
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FREM2 PFAS TARS2 NUP155 PAPSS2	6.77e-04	650	38	5	38777146
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RIOX2 SMARCA1 PFAS IGF2R NF1 TARS2 NUP155	7.90e-04	1425	38	7	30948266
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	PFAS ECEL1 IGF2R MON1B	8.67e-04	392	38	4	33144569
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJC5G DPH2 PFAS EEF2K IGF2R TARS2 NUP155	1.01e-03	1487	38	7	33957083
Pubmed	An Interaction Network of the Human SEPT9 Established by Quantitative Mass Spectrometry.	STING1 TNXB	1.02e-03	43	38	2	30975701
GeneFamily	Fibronectin type III domain containing	DSCAM TNXB EPHA3	1.06e-03	160	23	3	555
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK3 FREM2 DNAH7 CFAP46	1.17e-05	165	38	4	82530f96aaefe28a13bad0474bbad043f127a86c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK3 FREM2 DNAH7 CFAP46	1.17e-05	165	38	4	0c714e852f912b5749de4cb0895406673979b2e6
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DOCK3 ARHGAP22 ZFYVE26 IGF2R	1.22e-05	167	38	4	a48349f189f6a8d563744b0a294c3974f3a18f50
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP22 PFAS ZWILCH DSCAM	1.41e-05	173	38	4	6c9ecf77d2fb0f89100fdd7e4e88f85598278bc7
ToppCell	droplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGAP22 ECEL1 DSCAM PAPSS2	1.61e-05	179	38	4	4f20540bfbcefe0e83812be7ea542e8bb3bf19bc
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DNAJC5G DNAH7 CFAP46 EPHA3	1.72e-05	182	38	4	14a117c5e50db31ee1b2cf4df4d133451fd6d55f
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK3 FREM2 SLC16A11 DSCAM	2.21e-05	194	38	4	b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FREM2 PARD3B ZNRF3 DNAH7	2.30e-05	196	38	4	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FREM2 PARD3B ZNRF3 DNAH7	2.30e-05	196	38	4	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	Tracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_peribronchial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK3 NPR2 TNXB EPHA3	2.44e-05	199	38	4	e9009eee7f77b9c9917f8e0e723001d9e76eb553
Disease	Moyamoya Disease	RNF213 NF1	2.06e-04	17	37	2	C0026654
Disease	Drugs used in diabetes use measurement	SLC16A11 NF1 ZNRF3 DNAH7	2.88e-04	255	37	4	EFO_0009924

Protein segments in the cluster

Peptide	Gene	Start	Entry
RPFLKPGYRHHLIPS	CFAP46	141	Q8IYW2
GLAPHLTHYADLLPG	DPH2	376	Q9BQC3
DLKLYHDPDLLLGPG	NPR2	86	P20594
LHLGKPGHRSYALSP	ATXN1	416	P54253
YENIHLARLGPPAHK	LY6G6F	281	Q5SQ64
GAPGLRHFLYKPLDI	MON1B	406	Q7L1V2
ERGYKHPVLLLHPLG	PAPSS2	431	O95340
GHPLSPERDHLEGLY	PARD3B	986	Q8TEW8
PYVHLAPHALDRGLG	SLC16A11	261	Q8NCK7
LKIGGEPHISYPPLH	MAGEA2	291	P43356
HHKIAYRPPGQELGV	FREM2	781	Q5SZK8
LLYPCIDRHLGEPHK	INSIG2	86	Q9Y5U4
VREHGPEHPLPRLKY	ECEL1	691	O95672
DPQGLGLHFYKHGEP	NUP155	941	O75694
ALLPHPPFEYHLGRK	DNAJC5G	41	Q8N7S2
LNDSKKGPPHLHYRR	DOCK3	301	Q8IZD9
KPYHPRLPALEHDEG	DOCK3	1976	Q8IZD9
EHDPLKGRLSYPHPG	CPEB2	266	Q7Z5Q1
KYLAHGLPAGAPLRL	FITM1	206	A5D6W6
KHPPEDGVFIHGLFL	DNAH7	3916	Q8WXX0
GHLKLPGLRTYVDPH	EPHA3	586	P29320
PGKPLFHLEHYIEGK	EEF2K	221	O00418
KAHRPGDLIHLPPYL	DSCAM	1891	O60469
DPRHGNLYDLKPLGL	IGF2R	1231	P11717
YGPKIDVHLHDALGR	TARS2	536	Q9BW92
LGEPPEHTLRYLVLH	STING1	36	Q86WV6
LLGYLKHYRNIPGPH	SMARCA1	221	P28370
RDLHHAPLLPLYDGT	SPPL2C	51	Q8IUH8
VHHERKYGPRLAPLL	ARHGAP22	161	Q7Z5H3
YGLGSKKHPLHLLIP	C12orf29	206	Q8N999
PIGGIDHKPRDGFHL	RNF213	4531	Q63HN8
GEPRGPLNHLYRELK	ZWILCH	256	Q9H900
DLKHPEGRGHLLYVA	PFAS	841	O15067
KLLLYGLHHGKRVGP	TNXB	1841	P22105
VGHLLKGYRHPSPAI	NF1	2391	P21359
LKPGDLLYFPRGTIH	RIOX2	226	Q8IUF8
HRGREVGKDLPYPGL	nan	121	Q86TA4
LHPDHLPRTDGVKYE	ZNRF3	761	Q9ULT6
LEHPLLLEPGHRKFD	TTL	186	Q8NG68
PIPKRDLLYHLHGGD	ZFYVE26	426	Q68DK2
YELHGPHAAPKLLKA	THEGL	101	P0DJG4
LPGHQRIHTGEKPYI	ZNF300	536	Q96RE9