Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Atrioventricular valve regurgitation	TLR7 AIP ERI1 ADNP PPP1CB GTF2I ALG9 GTF2IRD2 LTBP3 FHL1	1.25e-05	196	49	10	HP:0034376
HumanPheno	Abnormal atrioventricular valve physiology	TLR7 AIP ERI1 ADNP PPP1CB GTF2I ALG9 GTF2IRD2 LTBP3 FHL1	2.82e-05	215	49	10	HP:0031650
Domain	-	GTF2IRD2B GTF2I GTF2IRD2	8.82e-07	4	114	3	3.90.1460.10
Domain	GTF2I	GTF2IRD2B GTF2I GTF2IRD2	8.82e-07	4	114	3	PS51139
Domain	GTF2I	GTF2IRD2B GTF2I GTF2IRD2	8.82e-07	4	114	3	PF02946
Domain	GTF2I	GTF2IRD2B GTF2I GTF2IRD2	8.82e-07	4	114	3	IPR004212
Domain	EGF-like_CS	HGFAC LAMB4 MATN3 ITGB3 JAG2 PROZ JAG1 CNTNAP4 LTBP3 C6	4.55e-06	261	114	10	IPR013032
Domain	EGF_2	HGFAC LAMB4 MATN3 ITGB3 JAG2 PROZ JAG1 CNTNAP4 LTBP3 C6	5.20e-06	265	114	10	PS01186
Domain	EGF	HGFAC MATN3 ITGB3 JAG2 PROZ JAG1 CNTNAP4	1.22e-05	126	114	7	PF00008
Domain	EGF-like_dom	HGFAC MATN3 JAG2 FCGBP PROZ JAG1 CNTNAP4 LTBP3 C6	2.21e-05	249	114	9	IPR000742
Domain	C1_1	UNC13B DGKE CDC42BPB UNC13A VAV2	2.52e-05	57	114	5	PF00130
Domain	EGF_1	HGFAC LAMB4 ITGB3 JAG2 PROZ JAG1 CNTNAP4 LTBP3 C6	2.67e-05	255	114	9	PS00022
Domain	Jagged/Serrate	JAG2 JAG1	3.69e-05	2	114	2	IPR026219
Domain	ZF_DAG_PE_1	UNC13B DGKE CDC42BPB UNC13A VAV2	4.44e-05	64	114	5	PS00479
Domain	ZF_DAG_PE_2	UNC13B DGKE CDC42BPB UNC13A VAV2	4.44e-05	64	114	5	PS50081
Domain	C1	UNC13B DGKE CDC42BPB UNC13A VAV2	4.78e-05	65	114	5	SM00109
Domain	PE/DAG-bd	UNC13B DGKE CDC42BPB UNC13A VAV2	5.15e-05	66	114	5	IPR002219
Domain	EGF	HGFAC MATN3 JAG2 FCGBP PROZ JAG1 CNTNAP4 LTBP3	9.76e-05	235	114	8	SM00181
Domain	EGF_3	HGFAC MATN3 JAG2 PROZ JAG1 CNTNAP4 LTBP3 C6	9.76e-05	235	114	8	PS50026
Domain	Unc-13	UNC13B UNC13A	1.10e-04	3	114	2	IPR027080
Domain	VWC_out	JAG2 FCGBP JAG1	2.00e-04	19	114	3	SM00215
Domain	PP2A_PR55_CS	PPP2R2B PPP2R2C	2.20e-04	4	114	2	IPR018067
Domain	PP2A_PR55	PPP2R2B PPP2R2C	2.20e-04	4	114	2	IPR000009
Domain	DSL	JAG2 JAG1	2.20e-04	4	114	2	PF01414
Domain	DSL	JAG2 JAG1	2.20e-04	4	114	2	SM00051
Domain	PR55_2	PPP2R2B PPP2R2C	2.20e-04	4	114	2	PS01025
Domain	PR55_1	PPP2R2B PPP2R2C	2.20e-04	4	114	2	PS01024
Domain	Munc13_dom-2	UNC13B UNC13A	3.65e-04	5	114	2	IPR014772
Domain	DSL	JAG2 JAG1	3.65e-04	5	114	2	PS51051
Domain	Notch_ligand_N	JAG2 JAG1	3.65e-04	5	114	2	IPR011651
Domain	MHD2	UNC13B UNC13A	3.65e-04	5	114	2	PS51259
Domain	Munc13_subgr_dom-2	UNC13B UNC13A	3.65e-04	5	114	2	IPR019558
Domain	MNNL	JAG2 JAG1	3.65e-04	5	114	2	PF07657
Domain	Membr_traf_MHD	UNC13B UNC13A	3.65e-04	5	114	2	PF10540
Domain	DSL	JAG2 JAG1	3.65e-04	5	114	2	IPR001774
Domain	DUF1041	UNC13B UNC13A	3.65e-04	5	114	2	SM01145
Domain	hEGF	JAG2 JAG1 LTBP3	6.49e-04	28	114	3	PF12661
Domain	Munc13_1	UNC13B UNC13A	7.60e-04	7	114	2	IPR014770
Domain	MHD1	UNC13B UNC13A	7.60e-04	7	114	2	PS51258
Domain	DUF1041	UNC13B UNC13A	7.60e-04	7	114	2	PF06292
Domain	CAPS_dom	UNC13B UNC13A	7.60e-04	7	114	2	IPR010439
Domain	EGF_CA	MATN3 JAG2 PROZ JAG1 LTBP3	9.12e-04	122	114	5	SM00179
Domain	EGF-like_Ca-bd_dom	MATN3 JAG2 PROZ JAG1 LTBP3	9.81e-04	124	114	5	IPR001881
Domain	Znf_C2H2-like	ZNF212 MATR3 REST GPATCH8 ZNF519 RREB1 ADNP CASZ1 GTF2IRD2B GTF2IRD2 ZHX1 RNF138 ZNF639	1.14e-03	796	114	13	IPR015880
Domain	ZnF_C2H2	ZNF212 MATR3 REST GPATCH8 ZNF519 RREB1 ADNP CASZ1 GTF2IRD2B GTF2IRD2 ZHX1 RNF138 ZNF639	1.30e-03	808	114	13	SM00355
Domain	VWC	JAG2 FCGBP JAG1	1.60e-03	38	114	3	SM00214
Domain	EGF_CA	MATN3 JAG2 JAG1 LTBP3	1.90e-03	86	114	4	PF07645
Domain	VWF_dom	JAG2 FCGBP JAG1	2.14e-03	42	114	3	IPR001007
Pubmed	TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.	GTF2IRD2B GTF2I GTF2IRD2	1.52e-07	4	118	3	17823943
Pubmed	Evolution of general transcription factors.	GTF2IRD2B GTF2I GTF2IRD2	1.52e-07	4	118	3	23229069
Pubmed	GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.	GTF2IRD2B GTF2I GTF2IRD2	1.52e-07	4	118	3	22899722
Pubmed	Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.	GTF2IRD2B GTF2I GTF2IRD2	1.52e-07	4	118	3	21328569
Pubmed	Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.	ZMYM2 ZNFX1 FBXO38 EIF3D ZHX1	1.89e-07	38	118	5	28680062
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DNAJC13 EOGT KIF1A ATP9B ARID1A CDC42BPB CASZ1 PPP1CB JAG2 PPP2R2C GTF2I WDR11 USP40 SHPRH STYXL1 KYAT3 PLEKHA2 CACNA1H VAV2	6.50e-07	1489	118	19	28611215
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	UNC13B GPRASP1 KIF1A ZMYM2 ZNFX1 GRIN2B AIP ARID1A UBASH3A CDC42BPB PREPL NAA25 MTM1 RNF216 LTBP3 EIF3D FHL1	1.66e-06	1285	118	17	35914814
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	GPRASP1 DNAJC13 MATR3 ZMYM2 ZNFX1 GRIN2B ADNP GRM5 CDC42BPB PREPL PPP1CB KIF15 SRGAP3 UNC13A	5.13e-06	963	118	14	28671696
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	SETX ZMYM2 GPATCH8 RREB1 ADNP CASZ1 FBXO38 GTF2I SHPRH TAF2 ZHX1	7.53e-06	608	118	11	36089195
Pubmed	Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.	UNC13B CDC42BPB PPP1CB WDR11 UNC13A RNF138 SLC27A4	7.68e-06	209	118	7	26389662
Pubmed	NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma.	JAG2 JAG1	1.14e-05	2	118	2	24708907
Pubmed	Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.	UNC13B UNC13A	1.14e-05	2	118	2	12070347
Pubmed	Regulation of insulin exocytosis by Munc13-1.	UNC13B UNC13A	1.14e-05	2	118	2	12871971
Pubmed	Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.	UNC13B UNC13A	1.14e-05	2	118	2	17561838
Pubmed	Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors.	UNC13B UNC13A	1.14e-05	2	118	2	23070049
Pubmed	Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool.	JAG2 JAG1	1.14e-05	2	118	2	38750026
Pubmed	Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.	UNC13B UNC13A	1.14e-05	2	118	2	28489077
Pubmed	Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.	UNC13B UNC13A	1.14e-05	2	118	2	10440375
Pubmed	Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.	UNC13B UNC13A	1.14e-05	2	118	2	22066784
Pubmed	Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.	UNC13B UNC13A	1.14e-05	2	118	2	32187536
Pubmed	Unique proline-rich domain regulates the chaperone function of AIPL1.	AIP AIPL1	1.14e-05	2	118	2	23418749
Pubmed	Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.	UNC13B UNC13A	1.14e-05	2	118	2	28772123
Pubmed	Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.	UNC13B UNC13A	1.14e-05	2	118	2	17267576
Pubmed	Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets.	UNC13B UNC13A	1.14e-05	2	118	2	22814762
Pubmed	Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.	UNC13B UNC13A	1.14e-05	2	118	2	28426965
Pubmed	A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution.	UNC13B UNC13A	1.14e-05	2	118	2	35613050
Pubmed	Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling.	UNC13B UNC13A	1.14e-05	2	118	2	23770256
Pubmed	Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable.	JAG2 JAG1	1.14e-05	2	118	2	28111308
Pubmed	Membrane bridging by Munc13-1 is crucial for neurotransmitter release.	UNC13B UNC13A	1.14e-05	2	118	2	30816091
Pubmed	Negative regulation of REST on NR2B in spinal cord contributes to the development of bone cancer pain in mice.	GRIN2B REST	1.14e-05	2	118	2	27732941
Pubmed	A common molecular basis for membrane docking and functional priming of synaptic vesicles.	UNC13B UNC13A	1.14e-05	2	118	2	19558619
Pubmed	Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C.	UNC13B UNC13A	1.14e-05	2	118	2	18701688
Pubmed	Neuron-restrictive silencer factor regulates the N-methyl-D-aspartate receptor 2B subunit gene in basal and ethanol-induced gene expression in fetal cortical neurons.	GRIN2B REST	1.14e-05	2	118	2	15755907
Pubmed	Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses.	UNC13B UNC13A	1.14e-05	2	118	2	31851910
Pubmed	Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction.	JAG2 JAG1	1.14e-05	2	118	2	11549580
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	1.14e-05	2	118	2	15388857
Pubmed	Differential control of vesicle priming and short-term plasticity by Munc13 isoforms.	UNC13B UNC13A	1.14e-05	2	118	2	11832228
Pubmed	Munc13 controls the location and efficiency of dense-core vesicle release in neurons.	UNC13B UNC13A	1.14e-05	2	118	2	23229896
Pubmed	Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs.	UNC13B UNC13A	1.14e-05	2	118	2	11792326
Pubmed	The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55.	GPRASP1 GPR55	1.14e-05	2	118	2	21718301
Pubmed	Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices.	GRIN2B GRM5	1.14e-05	2	118	2	21310164
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	SMG1 ZMYM2 LANCL1 ZNFX1 ARID1A ADCY2 PREPL PHF5A CASZ1 PPP2R2B TAF2	1.18e-05	638	118	11	31182584
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DNAJC13 MATR3 ZMYM2 REST GPATCH8 RREB1 PPP1CB FBXO38 GTF2I DDX21 ZHX1 CDC23	1.34e-05	774	118	12	15302935
Pubmed	Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.	PPP1CB PPP2R2B PPP2R2C	1.35e-05	14	118	3	16048649
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	UNC13B DNAJC13 EOGT RARS1 DGKE AIP CDC42BPB TMEM11 PPP2R2B GTF2I WDR11 MTM1 SLC27A4	1.74e-05	931	118	13	27432908
Pubmed	Regulation of HIV-1 transcription by protein phosphatase 1.	PPP1CB PPP2R2B PPP2R2C	2.50e-05	17	118	3	17266553
Pubmed	[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].	PPP1CB PPP2R2B PPP2R2C	2.50e-05	17	118	3	21351466
Pubmed	Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.	SMG1 GPRASP1 PREPL SRGAP3	3.01e-05	52	118	4	9455477
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SETX MATR3 ZMYM2 REST GPATCH8 RREB1 ARID1A ADNP PHF5A CASZ1 PPP1CB GTF2I DDX21 SLC27A4 CDC23	3.34e-05	1294	118	15	30804502
Pubmed	Potential role for a specialized β3 integrin-based structure on osteocyte processes in bone mechanosensation.	ITGB3 CACNA1H	3.42e-05	3	118	2	29087614
Pubmed	Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesicle priming.	UNC13B UNC13A	3.42e-05	3	118	2	37343100
Pubmed	Notch signaling drives multiple myeloma induced osteoclastogenesis.	JAG2 JAG1	3.42e-05	3	118	2	25257302
Pubmed	The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.	UNC13B UNC13A	3.42e-05	3	118	2	23658173
Pubmed	Regulation of dendritic cell differentiation in bone marrow during emergency myelopoiesis.	ITGB3 JAG1	3.42e-05	3	118	2	23833236
Pubmed	mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch.	GRIN2B GRM5	3.42e-05	3	118	2	21521618
Pubmed	Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency.	JAG2 JAG1	3.42e-05	3	118	2	24191040
Pubmed	Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells.	JAG2 JAG1	3.42e-05	3	118	2	9716576
Pubmed	KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300.	REST KIF15	3.42e-05	3	118	2	39430242
Pubmed	Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	3.42e-05	3	118	2	15100712
Pubmed	Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.	UNC13B UNC13A	3.42e-05	3	118	2	17639022
Pubmed	Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits.	PPP2R2B PPP2R2C	3.42e-05	3	118	2	9514514
Pubmed	Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.	UNC13B UNC13A	3.42e-05	3	118	2	33105896
Pubmed	β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.	JAG2 JAG1	3.42e-05	3	118	2	24907271
Pubmed	Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST).	REST CACNA1H	3.42e-05	3	118	2	22431737
Pubmed	Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.	JAG2 JAG1	3.42e-05	3	118	2	23530123
Pubmed	Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.	UNC13B UNC13A	3.42e-05	3	118	2	22966208
Pubmed	Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice.	JAG2 JAG1	3.42e-05	3	118	2	11841846
Pubmed	Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.	ITGB3 APBB1IP	3.42e-05	3	118	2	25520155
Pubmed	Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.	UNC13B UNC13A	3.42e-05	3	118	2	15988013
Pubmed	A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci.	ITGB3 ADCY2 ADAMTS16	4.16e-05	20	118	3	15329828
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DNAJC13 SETX RARS1 MATR3 LANCL1 ERI1 ARID1A ADNP PPP1CB GTF2I WDR11 EIF3D TAF2 DDX21 SLC27A4	5.54e-05	1353	118	15	29467282
Pubmed	Specification of SUMO1- and SUMO2-interacting motifs.	SETX ZMYM2 ZHX1	5.59e-05	22	118	3	16524884
Pubmed	Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo.	UNC13B UNC13A	6.82e-05	4	118	2	10488064
Pubmed	A mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochlea.	JAG2 JAG1	6.82e-05	4	118	2	10837254
Pubmed	Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate.	JAG2 JAG1	6.82e-05	4	118	2	20602435
Pubmed	Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.	JAG2 JAG1	6.82e-05	4	118	2	9315665
Pubmed	Activation of Notch signaling in human tongue carcinoma.	JAG2 JAG1	6.82e-05	4	118	2	20819128
Pubmed	Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor.	REST CACNA1H	6.82e-05	4	118	2	19342457
Pubmed	Prion protein is essential for the RE1 silencing transcription factor (REST)-dependent developmental switch in synaptic NMDA receptors.	GRIN2B REST	6.82e-05	4	118	2	29748616
Pubmed	Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration.	ITGB3 APBB1IP	6.82e-05	4	118	2	20404115
Pubmed	TRIADs: a new class of proteins with a novel cysteine-rich signature.	RNF14 RNF216	6.82e-05	4	118	2	10422847
Pubmed	Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.	UNC13B UNC13A	6.82e-05	4	118	2	19996097
Pubmed	Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.	UNC13B UNC13A	6.82e-05	4	118	2	15123597
Pubmed	ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.	UNC13B UNC13A	6.82e-05	4	118	2	28264913
Pubmed	Splicing factor ESRP1 derived circ_0068162 promotes the progression of oral squamous cell carcinoma via the miR-186/JAG axis.	JAG2 JAG1	6.82e-05	4	118	2	37966490
Pubmed	Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression.	GRIN2B GRM5	6.82e-05	4	118	2	24925192
Pubmed	Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws.	JAG2 JAG1	6.82e-05	4	118	2	20040020
Pubmed	Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex.	ARID1A ADNP	6.82e-05	4	118	2	17878164
Pubmed	The Notch signalling pathway in hair growth.	JAG2 JAG1	6.82e-05	4	118	2	9858728
Pubmed	Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse.	JAG2 JAG1	6.82e-05	4	118	2	24398584
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	SETX ZMYM2 RREB1 ADNP GTF2I	7.00e-05	125	118	5	32891193
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	DNAJC13 MATR3 ZMYM2 ARID1A PPP1CB GTF2I	7.03e-05	203	118	6	22083510
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DNAJC13 SETX MATR3 BTBD17 ZMYM2 LANCL1 GPATCH8 ARID1A ADNP PPP1CB EIF3D DDX21 UNC13A	8.11e-05	1082	118	13	38697112
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	MATR3 AIP ARID1A ADNP GTF2I	8.74e-05	131	118	5	34551306
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	DNAJC13 ZMYM2 RREB1 ADNP GTF2I KIF15 PLEKHA2 CDC23	9.42e-05	418	118	8	34709266
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	RARS1 MATR3 LANCL1 CDC42BPB PHF5A GTF2I WDR11 EIF3D FHL1 DDX21 CDC23	1.01e-04	809	118	11	32129710
Pubmed	3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling.	JAG2 JAG1	1.13e-04	5	118	2	30244870
Pubmed	An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.	UNC13B UNC13A	1.13e-04	5	118	2	34706221
Pubmed	Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors.	JAG2 JAG1	1.13e-04	5	118	2	11006133
Pubmed	Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions.	ITGB3 PPP1CB	1.13e-04	5	118	2	23197154
Interaction	GTF2IRD2B interactions	ZMYM2 GTF2IRD2B GTF2I GTF2IRD2	1.31e-06	15	115	4	int:GTF2IRD2B
Cytoband	20q13.13	RIPOR3 ZNFX1 ADNP	7.77e-05	32	118	3	20q13.13
Cytoband	7q11.23	GTF2IRD2B GTF2I GTF2IRD2 STYXL1	1.19e-04	97	118	4	7q11.23
GeneFamily	UNC13 homologs	UNC13B UNC13A	1.33e-04	4	86	2	836
GeneFamily	Ring finger proteins	MARCHF9 RNF14 RNF167 SHPRH RNF216 RNF180 RNF138	3.37e-04	275	86	7	58
GeneFamily	UPF1 like RNA helicases	SETX ZNFX1	1.20e-03	11	86	2	1169
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	PPP2R2B PPP2R2C	2.26e-03	15	86	2	696
GeneFamily	ATPase phospholipid transporting	ATP9B ATP9A	2.26e-03	15	86	2	1210
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ADNP ZHX1	2.26e-03	15	86	2	529
GeneFamily	FKBP prolyl isomerases	AIP AIPL1	3.26e-03	18	86	2	910
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	GPRASP1 KIF1A SLC24A3 DGKE ATP9A GRM5 NKAIN2 PREPL CASZ1 GFRA1 JAG2 PPP2R2B PPP2R2C SRGAP3 CNTNAP4 UNC13A VAV2	7.50e-06	1106	116	17	M39071
ToppCell	primary_visual_cortex-Neuronal\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GPRASP1 KIF1A MATR3 LANCL1 GRIN2B PREPL RNF14	9.37e-07	196	118	7	8efc2b3a95f57c31be203ac781b2098d4909297f
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Deep_Layer-37\|World / Primary Cells by Cluster	KIF1A SLC24A3 GRIN2B GRM5 GFRA1 PPP2R2C ADAMTS16	9.70e-07	197	118	7	00d756bc0231e1b3b88430214338c1059cb11106
Disease	X-23639 measurement	KIF1A KYAT3	1.49e-04	5	115	2	EFO_0800853
Disease	Profound Mental Retardation	TMEM135 ZMYM2 GRIN2B SRGAP3 TAF2	2.19e-04	139	115	5	C0020796
Disease	Mental Retardation, Psychosocial	TMEM135 ZMYM2 GRIN2B SRGAP3 TAF2	2.19e-04	139	115	5	C0025363
Disease	Mental deficiency	TMEM135 ZMYM2 GRIN2B SRGAP3 TAF2	2.19e-04	139	115	5	C0917816
Disease	Neurodevelopmental Disorders	GRIN2B ADNP CDC42BPB SRGAP3	4.89e-04	93	115	4	C1535926
Disease	Bone Diseases	JAG1 LTBP3	6.64e-04	10	115	2	C0005940
Disease	RETINITIS PIGMENTOSA	AIPL1 CFAP418	6.64e-04	10	115	2	268000
Disease	ocular hypertension, response to triamcinolone acetonide	MARCHF9 OTOGL CFAP61	9.32e-04	49	115	3	EFO_0006954, EFO_1001069
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	PPP2R2B PPP2R2C	9.69e-04	12	115	2	DOID:1441 (implicated_via_orthology)
Disease	Amyotrophic Lateral Sclerosis	SETX MATR3 UNC13A	1.52e-03	58	115	3	C0002736
Disease	Neuralgia, Supraorbital	GRM5 GFRA1	1.74e-03	16	115	2	C0038870
Disease	Neuralgia	GRM5 GFRA1	1.74e-03	16	115	2	C0027796
Disease	Neuralgia, Atypical	GRM5 GFRA1	1.74e-03	16	115	2	C0234247
Disease	Neuralgia, Stump	GRM5 GFRA1	1.74e-03	16	115	2	C0234249
Disease	Neuralgia, Iliohypogastric Nerve	GRM5 GFRA1	1.74e-03	16	115	2	C0423712
Disease	Neuralgia, Perineal	GRM5 GFRA1	1.74e-03	16	115	2	C0423711
Disease	Paroxysmal Nerve Pain	GRM5 GFRA1	1.74e-03	16	115	2	C0751373
Disease	Nerve Pain	GRM5 GFRA1	1.74e-03	16	115	2	C0751372
Disease	Neuralgia, Ilioinguinal	GRM5 GFRA1	1.74e-03	16	115	2	C0751371
Disease	Neuralgia, Vidian	GRM5 GFRA1	1.74e-03	16	115	2	C0042656
Disease	Intellectual Disability	RARS1 TMEM135 ZMYM2 GRIN2B PREPL SRGAP3 TAF2	1.88e-03	447	115	7	C3714756
Disease	Fetal Alcohol Syndrome	REST ADNP	1.97e-03	17	115	2	C0015923
Disease	food allergy measurement, parental genotype effect measurement	RNASE9 PROZ	2.21e-03	18	115	2	EFO_0005939, EFO_0007016
Disease	Schizophrenia	GRIN2B REST ADNP GRM5 ITGB3 GFRA1 JAG2 WDR11 SRGAP3 JAG1	2.41e-03	883	115	10	C0036341
Disease	Infiltrating duct carcinoma of female breast	SMG1 CDC42BPB	3.01e-03	21	115	2	C3165106
Disease	Autistic Disorder	KIF1A GRIN2B ADNP ITGB3 CACNA1H	3.63e-03	261	115	5	C0004352
Disease	Glioblastoma	TMEM135 JAG2 JAG1	3.68e-03	79	115	3	C0017636
Disease	epilepsy (implicated_via_orthology)	UNC13B SLC24A3 GRIN2B UNC13A	3.86e-03	163	115	4	DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VKDCVKACLNSTYEY	UNC13A	996	Q9UPW8
QADSVEQAVYYCKKC	ADNP	156	Q9H2P0
YYDYICIIDFEATCE	ERI1	126	Q8IV48
AVFELYNCEDERCYL	EOGT	441	Q5NDL2
SLYENDCIFDKFECV	PPP2R2B	331	Q00005
SLYENDCIFDKFECA	PPP2R2C	331	Q9Y2T4
ACDYLCISFEYSTIK	BTBD10	251	Q9BSF8
IDKYRVETCCVIGNY	CDC23	326	Q9UJX2
AAQCYIKYIQDIYSC	CDC23	486	Q9UJX2
AAFCIQLFCIDEKYE	CFAP61	386	Q8NHU2
YCQCLLKKEEYYEVL	AIPL1	236	Q9NZN9
RFDLYEDCKDAACQF	CASZ1	1436	Q86V15
LAFVSCICELYFYKA	ALG9	146	Q9H6U8
DCAAVFDKFIRYLYC	BTBD17	111	A6NE02
KESQYIKYLCCDDTR	APBB1IP	391	Q7Z5R6
RCIACDFLVVSYDDY	CFAP418	131	Q96NL8
NRAEHCEQEFTYYCK	CNTNAP4	671	Q9C0A0
CEQEFTYYCKKSRLV	CNTNAP4	676	Q9C0A0
QDLCKLYCIAEGFDF	ADAMTS16	676	Q8TE57
NYCQCKLVVEEYYEV	AIP	236	O00170
VQCACFSKDDKYVYV	NWD1	1436	Q149M9
KYDAQDLEEFCFRFC	RCBTB2	501	O95199
YIQCLYAFECKIERG	ARID1A	1096	O14497
FKCTFINDFDCYLTE	PADI6	656	Q6TGC4
AGDNERVYKCIICTY	REST	241	Q13127
PCKENEYVFDEYTCK	GRM5	536	P41594
EYVFDEYTCKACQLG	GRM5	541	P41594
CECYEGYTLNEDRKT	MATN3	331	O15232
FYCKLCSLFYTNEEV	MATR3	801	P43243
LCKCSFIEIYNEQIY	KIF15	161	Q9NS87
KVFREEKYLCDAYQC	LANCL1	291	O43813
ECDTYVRVCLKEYQA	JAG2	66	Q9Y219
SLICKYVPCEQFEDY	LRRC53	571	A6NM62
CLKYYEHEFVELACQ	ATP9B	826	O43861
KQCKDIYCDYLDFGI	IL12RB2	171	Q99665
DQGECSRKCYYIFIV	KCNG4	251	Q8TDN1
DLRANFYCELCDKQY	GPATCH8	131	Q9UKJ3
GFIYACYVVKCITEE	NKAIN2	161	Q5VXU1
VECSVFYRDECIYQK	LRATD2	81	Q96KN1
VCLKYYEYEFMELAC	ATP9A	736	O75110
RAYAVVCDCKLFLYD	CDC42BPB	1116	Q9Y5S2
CCLDVFCYYFVIKEF	GPR55	281	Q9Y2T6
DCGTEKCFDETRYEY	HGFAC	196	Q04756
CQEKDYHFEYTECDS	ELAPOR2	61	A8MWY0
CAIYMFYALAIVCDD	SLC24A3	116	Q9HC58
SCELCYFKYQVLAIS	MARCHF9	151	Q86YJ5
AECRFKECVFENYYV	FGF11	141	Q92914
YFYCEILQLFKISCT	OR5AC1	176	P0C628
CASINRIYGFYDECK	PPP1CB	126	P62140
NEVFSCIKYLAIYNC	FBXO38	396	Q6PIJ6
QICSLKAEDTAVYYC	IGHV7-4-1	101	A0A0J9YVY3
TAVEDQYYCVDCYKN	FHL1	201	Q13642
HDIKYNCCEEIYTDI	CHRNA6	216	Q15825
EELYHQSYDCVCVMF	ADCY2	876	Q08462
VVDKYYQENFCEQIC	C6	51	P13671
SCLKENYADCLLAYS	GFRA1	276	P56159
EYFRQCVYDLCAQKG	FCGBP	5071	Q9Y6R7
QDIECCGALEYYDKA	EIF3D	191	O15371
KIYNPSEQCCYDDAI	IGFL3	46	Q6UXB1
EKCYVLTFAEYCRFC	BAHD1	706	Q8TBE0
YISKCYSVAAQFEEC	DNAJC13	1476	O75165
KKECYLNFDDTVFCD	LTBP3	916	Q9NS15
CTYKNEDDCVVRFQY	ITGB3	681	P05106
KYCILSYLEGEQKCF	LAMB4	56	A4D0S4
VYLFYGTKDCLVQEC	DGKE	406	P52429
ESEVYYILCKTEAKC	DEFB121	36	Q5J5C9
VCICFYQHKEEYQLV	DDX21	536	Q9NR30
ILRKAVEDYFCFCYG	GTF2IRD2	106	Q86UP8
ILRKAVEDYFCFCYG	GTF2IRD2B	106	Q6EKJ0
TLRKTVEDYFCFCYG	GTF2I	111	P78347
DEALKYCNYVFTIVF	CACNA1H	1646	O95180
CIKYDTLCISDEVYE	KYAT3	236	Q6YP21
EYVCKALQELYGVNC	PRIMPOL	136	Q96LW4
CKYDLLVYFEICELE	KIF1A	1131	Q12756
QKFDPVYDCSQYICL	OTOGL	1476	Q3ZCN5
IKYLEEDFCYAIECL	OTOGL	2131	Q3ZCN5
NEYAEEKDSYICAVC	RNF180	421	Q86T96
EKDSYICAVCLDVYF	RNF180	426	Q86T96
CDTYFKVCLKEYQSR	JAG1	71	P78504
YICKVCEETLAYSVD	GPRASP1	1236	Q5JY77
VYDICCFDSFEYVKT	RASL10B	91	Q96S79
ALDDFTICYFKCEQD	PLEKHA2	221	Q9HB19
FYDSCYCVEKDRQTG	RARS1	611	P54136
DCYEALVIYNFLSLC	TMEM184B	116	Q9Y519
YSCFKTVFIDEAYVE	TAF2	301	Q6P1X5
EVINYLGNKACECYI	SMG1	1181	Q96Q15
YQKGDQYDVCAICLD	RNF167	221	Q9H6Y7
YTEDDFYCPVCQEVL	RNF138	11	Q8WVD3
DLCYCLECVAEYHKA	SETX	36	Q7Z333
CVFCKADELFTEYES	SHPRH	1241	Q149N8
EGNLEKECYEEICVY	PROZ	51	P22891
FCKECLIRYAQEAVF	RNF216	536	Q9NWF9
YCNLTEAFEIPACKY	RNASE9	141	P60153
FLCYICKEYVEDLAK	PRXL2C	66	Q7RTV5
VYCKACLKDYFEIQI	RNF14	241	Q9UBS8
CKYEYFDLAADVLAE	TTC30B	331	Q8N4P2
ICKYCDYKTVIFENL	ZNF639	261	Q9UID6
FLENYYNCNECEKVF	ZNF519	176	Q8TB69
CCKYQVEYDAYKLSR	TMEM11	131	P17152
TFINKCYELCDTYPA	MTM1	186	Q13496
VDLECVKYCVVYDNN	STYXL1	66	Q9Y6J8
KYYIHDVSDLIDCCD	SRGAP3	256	O43295
ISKVDELYEDYCIQC	RIPOR3	136	Q96MK2
YQCNICDYIAADKAA	RREB1	671	Q92766
DDCIKYNCTIVQYIG	SLC27A4	321	Q6P1M0
SYVCVECNFLTKRYD	ZHX1	101	Q9UKY1
YEDNCISYCIKGFIR	TMEM135	246	Q86UB9
VYYQEGCCLVRSKDE	PREPL	121	Q4J6C6
KDCVKACLNSTYEYI	UNC13B	921	O14795
ESYELQICVKDYCFA	UNC13B	1506	O14795
SPDCCYDAFIVYDTK	TLR7	886	Q9NYK1
IIYCYCNGEVQAEVK	PTH2R	411	P49190
FVVELCKYFLCQEYL	ZNFX1	1136	Q9P2E3
CIVTYCEYCQEEKTL	ZMYM2	676	Q9UBW7
YECDECRKTFYDKTV	ZNF717	786	Q9BY31
CKYEYFDLAADVLAE	TTC30A	331	Q86WT1
YECSECEITFRYKQQ	ZNF212	316	Q9UDV6
CCLLEIQETEAKYYR	VAV2	201	P52735
VTEFYAANALCYCDK	TINAG	71	Q9UJW2
CYDVLCENAYFQKFQ	WDR11	966	Q9BZH6
VSDAYYCKECTIQEK	PHF5A	66	Q7RTV0
YVEEEVFDCDNLYHC	USP40	206	Q9NVE5
CFECYGYDIIIDDKL	TTLL1	306	O95922
FFTCEDQKVECLYEA	UBASH3A	116	P57075
CLKTELQFSDYYCLL	NAA25	456	Q14CX7
YCTKEEATYIFEVAN	GRIN2B	231	Q13224