Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR2 RYR3	1.34e-04	4	95	2	GO:0005219
Domain	ARM-type_fold	STK36 NCAPD3 ATR DOCK11 USP9X RTTN TOGARAM2 COPG2 RYR3 FOCAD EIF4G2 ULK4 BRAT1 ARMH3 GCN1 TBCD	1.24e-11	339	94	16	IPR016024
Domain	-	STK36 NCAPD3 ATR USP9X RTTN TOGARAM2 COPG2 ULK4 BRAT1 GCN1 TBCD	1.52e-08	222	94	11	1.25.10.10
Domain	HEAT_REPEAT	NCAPD3 ATR COPG2 ULK4 BRAT1 GCN1 TBCD	6.04e-08	70	94	7	PS50077
Domain	ARM-like	STK36 NCAPD3 ATR USP9X RTTN TOGARAM2 COPG2 ULK4 BRAT1 GCN1 TBCD	1.12e-07	270	94	11	IPR011989
Domain	HEAT	STK36 NCAPD3 ATR BRAT1 GCN1 TBCD	1.43e-07	48	94	6	PF02985
Domain	HEAT	STK36 NCAPD3 ATR BRAT1 GCN1 TBCD	4.53e-07	58	94	6	IPR000357
Domain	Ryanrecept_TM4-6	RYR2 RYR3	7.49e-05	3	94	2	IPR009460
Domain	RyR	RYR2 RYR3	7.49e-05	3	94	2	PF02026
Domain	Ryanodine_rcpt	RYR2 RYR3	7.49e-05	3	94	2	IPR003032
Domain	RR_TM4-6	RYR2 RYR3	7.49e-05	3	94	2	PF06459
Domain	Ryan_recept	RYR2 RYR3	7.49e-05	3	94	2	IPR013333
Domain	TPR-like_helical_dom	ATR TTC21A KDM6B INTS8 CCNF CFAP70 CDC27	1.75e-04	233	94	7	IPR011990
Domain	WD40_repeat_CS	COPA WDR11 WDR41 TAF5L ATG16L2 WDR72	1.80e-04	164	94	6	IPR019775
Domain	-	COPA WDR11 WDR41 TAF5L HPS5 PLXNB3 ATG16L2 WDR72	2.76e-04	333	94	8	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	COPA WDR11 WDR41 TAF5L HPS5 PLXNB3 ATG16L2 WDR72	2.87e-04	335	94	8	IPR015943
Domain	DUF3398	DOCK11 DOCK6	3.71e-04	6	94	2	PF11878
Domain	RIH_assoc	RYR2 RYR3	3.71e-04	6	94	2	PF08454
Domain	RIH_assoc-dom	RYR2 RYR3	3.71e-04	6	94	2	IPR013662
Domain	RIH_dom	RYR2 RYR3	3.71e-04	6	94	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 RYR3	3.71e-04	6	94	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 RYR3	3.71e-04	6	94	2	IPR015925
Domain	-	RYR2 RYR3	3.71e-04	6	94	2	1.25.10.30
Domain	RYDR_ITPR	RYR2 RYR3	3.71e-04	6	94	2	PF01365
Domain	DOCK_C/D_N	DOCK11 DOCK6	3.71e-04	6	94	2	IPR021816
Domain	Ins145_P3_rec	RYR2 RYR3	3.71e-04	6	94	2	PF08709
Domain	-	ATR TTC21A KDM6B INTS8 CCNF CFAP70	6.24e-04	207	94	6	1.25.40.10
Domain	WD40_repeat_dom	COPA WDR11 WDR41 TAF5L HPS5 ATG16L2 WDR72	7.53e-04	297	94	7	IPR017986
Domain	G-protein_beta_WD-40_rep	COPA WDR41 TAF5L ATG16L2	8.92e-04	85	94	4	IPR020472
Domain	MIR	RYR2 RYR3	1.10e-03	10	94	2	PS50919
Domain	MIR	RYR2 RYR3	1.10e-03	10	94	2	PF02815
Domain	MIR	RYR2 RYR3	1.10e-03	10	94	2	SM00472
Domain	MIR_motif	RYR2 RYR3	1.10e-03	10	94	2	IPR016093
Domain	DOCK_C	DOCK11 DOCK6	1.34e-03	11	94	2	IPR010703
Domain	DHR-1_domain	DOCK11 DOCK6	1.34e-03	11	94	2	IPR027007
Domain	DHR_2	DOCK11 DOCK6	1.34e-03	11	94	2	PS51651
Domain	DHR_1	DOCK11 DOCK6	1.34e-03	11	94	2	PS51650
Domain	DOCK-C2	DOCK11 DOCK6	1.34e-03	11	94	2	PF14429
Domain	DHR-2	DOCK11 DOCK6	1.34e-03	11	94	2	IPR027357
Domain	DHR-2	DOCK11 DOCK6	1.34e-03	11	94	2	PF06920
Domain	DOCK	DOCK11 DOCK6	1.34e-03	11	94	2	IPR026791
Domain	WD40	COPA WDR11 WDR41 TAF5L ATG16L2 WDR72	1.97e-03	259	94	6	PF00400
Domain	WD40	COPA WDR11 WDR41 TAF5L ATG16L2 WDR72	2.34e-03	268	94	6	SM00320
Domain	TPR_8	TTC21A CFAP70 CDC27	2.41e-03	53	94	3	PF13181
Domain	WD40_repeat	COPA WDR11 WDR41 TAF5L ATG16L2 WDR72	2.52e-03	272	94	6	IPR001680
Domain	WD_REPEATS_1	COPA WDR11 WDR41 TAF5L ATG16L2 WDR72	2.81e-03	278	94	6	PS00678
Domain	WD_REPEATS_2	COPA WDR11 WDR41 TAF5L ATG16L2 WDR72	2.86e-03	279	94	6	PS50082
Domain	WD_REPEATS_REGION	COPA WDR11 WDR41 TAF5L ATG16L2 WDR72	2.86e-03	279	94	6	PS50294
Domain	HEAT_type_2	ATR GCN1	3.24e-03	17	94	2	IPR021133
Domain	Cyclin_C	CCNO CCNF	3.24e-03	17	94	2	PF02984
Domain	Cyclin_C-dom	CCNO CCNF	3.24e-03	17	94	2	IPR004367
Domain	Cyclin_C	CCNO CCNF	3.24e-03	17	94	2	SM01332
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	CAD COPA USP9X CYP51A1 NUP98 COPG2 THOC2 NEK9 GRHPR EIF4G2 UMPS CDC27 GCN1	3.28e-09	534	97	13	35032548
Pubmed	The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.	CAD USP9X NEK9 LIPA WDR11 UMPS BRAT1 ABHD12 TBCD	3.38e-07	325	97	9	36168628
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	NCAPD3 COPA USP9X CYP51A1 NUP98 COPG2 INTS8 EIF4G2 UMPS BRAT1 GCN1 ABHD12 TBCD VCPIP1	3.61e-07	942	97	14	31073040
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	NCAPD3 CAD COPA USP9X CYP51A1 RFC5 THOC2 NEK9 WDR11 ALDH18A1 UMPS WDR41 CDC27 BRAT1 GCN1 TBCD	3.89e-07	1257	97	16	37317656
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	COPA CYP51A1 COPG2 RFC5 WDR11 BAZ1A EIF4G2 ALDH18A1 WDR41 CDC27 TBCD	4.88e-07	560	97	11	35241646
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	YPEL3 DCHS2 COPA USP9X PARVB KDM6B INTS8 RYR3 FOCAD GRHPR ZNF592 EIF4G2 MACF1 ABHD12 PLXNB3 VCPIP1	5.21e-07	1285	97	16	35914814
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	ATR COPG2 COG3 TBCD	9.50e-07	27	97	4	23027611
Pubmed	A 3-Mb map of a large Segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14.	ARHGAP11A ULK4 ARHGAP11B	1.17e-06	8	97	3	11829490
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DCHS2 DOCK11 USP9X OBSCN TOGARAM2 RFC5 KMO RYR3 ZNF592 ARMH3	1.34e-06	497	97	10	36774506
Pubmed	Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region.	ARHGAP11A RYR3 ARHGAP11B	1.75e-06	9	97	3	17554679
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	NCAPD3 CAD COPA RFC5 THOC2 AMZ2 WDR11 ZNF592 EIF4G2 ALDH18A1 CDC27 GCN1	2.70e-06	809	97	12	32129710
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	NCAPD3 COPA USP9X RFC5 BAZ1A EIF4G2 UMPS GCN1	4.38e-06	332	97	8	32786267
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	CAD COPA USP9X COPG2 ALDH18A1 MACF1 GCN1	4.51e-06	235	97	7	28378594
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	ATR COPA COPG2 PARVB RFC5 INTS8 MACF1 UMPS CDC27 GCN1	5.44e-06	582	97	10	20467437
Pubmed	A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification.	ARHGAP11A ARHGAP11B	7.70e-06	2	97	2	27957544
Pubmed	Protooncogenic Role of ARHGAP11A and ARHGAP11B in Invasive Ductal Carcinoma: Two Promising Breast Cancer Biomarkers.	ARHGAP11A ARHGAP11B	7.70e-06	2	97	2	38046902
Pubmed	Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD.	CAD UMPS	7.70e-06	2	97	2	15890648
Pubmed	Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.	RYR2 RYR3	7.70e-06	2	97	2	21531043
Pubmed	Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.	RYR2 RYR3	7.70e-06	2	97	2	16678258
Pubmed	Phylogenetic relationships of the seven coat protein subunits of the coatomer complex, and comparative sequence analysis of murine xenin and proxenin.	COPA COPG2	7.70e-06	2	97	2	11530856
Pubmed	Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.	RYR2 RYR3	7.70e-06	2	97	2	8898078
Pubmed	ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum.	STK36 ULK4	7.70e-06	2	97	2	36989043
Pubmed	The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.	RYR2 RYR3	7.70e-06	2	97	2	14550562
Pubmed	Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.	RYR2 RYR3	7.70e-06	2	97	2	14985349
Pubmed	ArhGAP11A mediates amyloid-β generation and neuropathology in an Alzheimer's disease-like mouse model.	ARHGAP11A ARHGAP11B	7.70e-06	2	97	2	37302068
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CAD COPA USP9X NUP98 COPG2 THOC2 NEK9 EIF4G2 UMPS GCN1	1.21e-05	638	97	10	33239621
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	STK36 RTTN OBSCN PARVB KDM6B FOCAD ZNF592 ULK4 BRAT1 DOCK6 GCN1 TBCD PPP1R16A	1.24e-05	1105	97	13	35748872
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	NCAPD3 CAD ATR COPA DOCK6 GCN1	2.27e-05	202	97	6	33005030
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR2 RYR3	2.31e-05	3	97	2	18403125
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR2 RYR3	2.31e-05	3	97	2	18434746
Pubmed	Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.	RYR2 RYR3	2.31e-05	3	97	2	29730765
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR2 RYR3	2.31e-05	3	97	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR2 RYR3	2.31e-05	3	97	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR2 RYR3	2.31e-05	3	97	2	21881589
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR2 RYR3	2.31e-05	3	97	2	12213830
Pubmed	Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH.	CAD UMPS	2.31e-05	3	97	2	22692683
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR2 RYR3	2.31e-05	3	97	2	9242641
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR2 RYR3	2.31e-05	3	97	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR2 RYR3	2.31e-05	3	97	2	10788707
Pubmed	RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.	RYR2 RYR3	2.31e-05	3	97	2	15024040
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR2 RYR3	2.31e-05	3	97	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR2 RYR3	2.31e-05	3	97	2	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR2 RYR3	2.31e-05	3	97	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR2 RYR3	2.31e-05	3	97	2	11159936
Pubmed	The genomic and clinical landscape of fetal akinesia.	RYR3 GCN1	2.31e-05	3	97	2	31680123
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR2 RYR3	2.31e-05	3	97	2	10473538
Pubmed	The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.	CYP51A1 MARCHF6	2.31e-05	3	97	2	31904814
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR2 RYR3	2.31e-05	3	97	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR2 RYR3	2.31e-05	3	97	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR2 RYR3	2.31e-05	3	97	2	7635066
Pubmed	Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors.	CAD COPA USP9X COPG2 GCN1	2.74e-05	125	97	5	36030824
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	CAD COPA USP9X COPG2 EIF4G2 ALDH18A1 MACF1 CDC27 GCN1 VCPIP1	2.94e-05	708	97	10	39231216
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	COPG2 WDR11 EIF4G2 ARMH3 GCN1 VCPIP1	3.30e-05	216	97	6	31519766
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	DOCK11 TTC21A OBSCN ST3GAL4 ARHGAP11A FOCAD GRHPR ZNF592 ALDH18A1 PLXNB3	4.07e-05	736	97	10	29676528
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	NCAPD3 CAD ATR COPA USP9X NUP98 RFC5 THOC2 NEK9 BAZ1A EIF4G2 ALDH18A1 TAF5L GCN1	4.10e-05	1425	97	14	30948266
Pubmed	cDNA cloning, expression analysis, and chromosomal localization of a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G.	NUP98 EIF4G2	4.60e-05	4	97	2	9027506
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR2 RYR3	4.60e-05	4	97	2	18206662
Pubmed	Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis.	ARHGAP11A ARHGAP11B	4.60e-05	4	97	2	31883789
Pubmed	Structural basis for the BRCA1 BRCT interaction with the proteins ATRIP and BAAT1.	CDC27 BRAT1	4.60e-05	4	97	2	24073851
Pubmed	Survival kinase genes present prognostic significance in glioblastoma.	NEK9 ULK4	4.60e-05	4	97	2	26956052
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR2 RYR3	4.60e-05	4	97	2	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR2 RYR3	4.60e-05	4	97	2	9384575
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR2 RYR3	4.60e-05	4	97	2	9607712
Pubmed	Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development.	ARHGAP11A ARHGAP11B	4.60e-05	4	97	2	36924763
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR2 RYR3	4.60e-05	4	97	2	23482488
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	CAD COPA USP9X NUP98 FOCAD ALDH18A1 GCN1	5.22e-05	344	97	7	36282215
Pubmed	Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.	CAD COPA COPG2 THOC2 ALDH18A1 GCN1	6.07e-05	241	97	6	23125841
Pubmed	Proteomic analysis identifies novel binding partners of BAP1.	CAD COPA COPG2 GCN1	7.64e-05	80	97	4	34591877
Pubmed	Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1.	NUP98 EIF4G2	7.66e-05	5	97	2	10321731
Pubmed	Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.	RYR2 RYR3	7.66e-05	5	97	2	33060591
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR2 RYR3	7.66e-05	5	97	2	23918386
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR2 RYR3	7.66e-05	5	97	2	19011160
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CAD COPA USP9X NUP98 COPG2 THOC2 ALDH18A1 MACF1 GCN1	9.03e-05	653	97	9	22586326
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	CAD COPA NUP98 GPRC5A RFC5 THOC2 BAZ1A ALDH18A1 MACF1	9.79e-05	660	97	9	32780723
Pubmed	Defining the membrane proteome of NK cells.	NCAPD3 CAD COPA USP9X CYP51A1 MARCHF6 ST3GAL4 KSR1 WDR11 EIF4G2 BRAT1 GCN1	1.00e-04	1168	97	12	19946888
Pubmed	Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.	CAD COPA USP9X UMPS	1.01e-04	86	97	4	25044020
Pubmed	HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.	COPA USP9X CDC27 GCN1	1.06e-04	87	97	4	33711283
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR2 RYR3	1.15e-04	6	97	2	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR2 RYR3	1.15e-04	6	97	2	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR2 RYR3	1.15e-04	6	97	2	23463619
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR2 RYR3	1.15e-04	6	97	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR2 RYR3	1.15e-04	6	97	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR2 RYR3	1.15e-04	6	97	2	25966694
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR2 RYR3	1.15e-04	6	97	2	19009018
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR2 RYR3	1.15e-04	6	97	2	16844763
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	CAD USP9X CYP51A1 GPRC5A EIF4G2 UMPS GCN1	1.18e-04	392	97	7	33144569
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NCAPD3 MARCHF6 KDM6B ARHGAP11A ZNF592 HPS5 DOCK6 ARHGAP11B	1.20e-04	529	97	8	14621295
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	EFL1 CAD ATR COPA NUP98 RFC5 THOC2 ZNF592 BAZ1A EIF4G2 BRAT1	1.24e-04	1014	97	11	32416067
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	NCAPD3 CAD ATR COPA USP9X AMZ2 GCN1	1.25e-04	396	97	7	26687479
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	CAD DOCK11 USP9X COPG2 EIF4G2 DOCK6 GCN1	1.31e-04	399	97	7	37536630
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	STK36 CAD RYR3 AMZ2 GCN1 VCPIP1	1.49e-04	284	97	6	29459677
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	COPA USP9X COPG2 NEK9 KSR1 PTPDC1 EIF4G2 TSTD2 CDC27 DOCK6 ATG16L2	1.52e-04	1038	97	11	26673895
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	NCAPD3 EFL1 CAD COPA COPG2 RFC5 GRHPR GCN1 VCPIP1	1.59e-04	704	97	9	29955894
Pubmed	Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition.	NUP98 CDC27	1.60e-04	7	97	2	16479161
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR2 RYR3	1.60e-04	7	97	2	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR2 RYR3	1.60e-04	7	97	2	20962236
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	NCAPD3 COPA USP9X THOC2 ALDH18A1	1.62e-04	182	97	5	32239614
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	USP9X CYP51A1 COPG2 GRHPR ALDH18A1 UMPS BRAT1 GCN1 RABGGTA TBCD	1.73e-04	878	97	10	37223481
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	NCAPD3 ATR USP9X COPG2 COG3 INTS8 NEK9 FOCAD MACF1 DOCK6 WDR72	1.84e-04	1061	97	11	33845483
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	CYP51A1 NUP98 COPG2 WDR11 EIF4G2 WDR41 GCN1 VCPIP1	1.95e-04	568	97	8	37774976
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR2 RYR3	3.58e-05	3	63	2	287
GeneFamily	WD repeat domain containing	COPA WDR11 WDR41 TAF5L ATG16L2 WDR72	2.98e-04	262	63	6	362
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RTTN SLC35C2 CCNF BAZ1A ULK4 ABHD12	1.85e-06	168	97	6	a1755afa2cc50960ba60e07d84d61be429cdea72
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC-Cycling_T\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	NCAPD3 ARHGAP11A CCNF TRBV14 CLEC2D ARHGAP11B	4.12e-06	193	97	6	bec113472c40c0106a9427248cbcf54548797596
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK11 TRBV14 CLEC2D KIR3DL2 ARHGAP11B	3.84e-05	173	97	5	79d11f94a8f6a420c18c2fef0da77e9af3204765
ToppCell	facs-Skin-Anagen-24m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC21A ARHGAP11A CCNF ZNF804B CFAP70	4.28e-05	177	97	5	8a0f0fbb06cdacb99a3fdba0da3e0494b891db4f
ToppCell	facs-Skin-Anagen-24m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC21A ARHGAP11A CCNF ZNF804B CFAP70	4.28e-05	177	97	5	e9d7682517fb30fd2ad535d59779d718a7024c13
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-lung_ciliated_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STK36 MAB21L4 TTC21A ACOX2 CFAP70	4.28e-05	177	97	5	d947ba38db1772fc5fdcdc211f7511c4aa699dee
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STK36 MAB21L4 TTC21A ACOX2 CFAP70	4.28e-05	177	97	5	d5640f0097878f0dac671e51dc51310278bb2682
ToppCell	droplet-Lung-LUNG-30m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 MAB21L4 TTC21A TOGARAM2 ACOX2	5.02e-05	183	97	5	3991830726d05cf19606d540de04093985b7bdeb
ToppCell	droplet-Lung-LUNG-30m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 MAB21L4 TTC21A TOGARAM2 ACOX2	5.02e-05	183	97	5	cc844f54c7564bf432b179ca63bc7c4b9b8cfdd9
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 OBSCN RYR2 RYR3 OTOG	5.15e-05	184	97	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 OBSCN RYR2 RYR3 OTOG	5.15e-05	184	97	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 OBSCN RYR2 RYR3 OTOG	5.15e-05	184	97	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	PARVB FOCAD KIAA1958 TAF5L GCN1	5.56e-05	187	97	5	1eed2c1a05e80a7c8f639437c117afe0c18dfb0c
ToppCell	Endothelial-B-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	TTC21A NUP98 PTPDC1 UMPS DOCK6	5.70e-05	188	97	5	ecb74d67314a43b5805b7f2a7bb9ff6c5a60200a
ToppCell	facs-Lung-nan-3m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 TOGARAM2 ACOX2 ULK4 CFAP70	5.99e-05	190	97	5	e243b5fbb17b9ec3cc90bbe970c1d30b0fd1c2e1
ToppCell	facs-Lung-nan-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 TOGARAM2 ACOX2 ULK4 CFAP70	5.99e-05	190	97	5	fe844559b95832845d2e8d3ab4b57e3d558bc372
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	NCAPD3 ARHGAP11A RFC5 CCNF TBCD	5.99e-05	190	97	5	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	human_hepatoblastoma-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	NCAPD3 RTTN ARHGAP11A CCNF TBCD	6.46e-05	193	97	5	4b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCell	proximal-Hematologic-Natural_Killer_T-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZNF765 COG3 RFC5 PTPDC1 TBCD	6.78e-05	195	97	5	4d7c2c4d0130c2d46877ff6dd4584525d8f74daf
ToppCell	proximal-3-Hematologic-Natural_Killer_T\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZNF765 COG3 RFC5 PTPDC1 TBCD	6.78e-05	195	97	5	93093545bb23d2619ace029a52cffa1f673a0c2a
ToppCell	proximal-Hematologic-Natural_Killer_T\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZNF765 COG3 RFC5 PTPDC1 TBCD	6.78e-05	195	97	5	3944e4800f5d904d4efa401ce8913ec0e0781211
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	NCAPD3 ARHGAP11A RFC5 CCNF ARHGAP11B	6.94e-05	196	97	5	9591a6a3477ed6a1e2e016f7542e38603d8b16cb
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	NCAPD3 ARHGAP11A RFC5 CCNF ARHGAP11B	7.46e-05	199	97	5	88d130e2451e61afb710edf552e6b346b9fcfb2b
ToppCell	BL-critical-LOC-Lymphoid-Treg\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NCAPD3 ARHGAP11A RFC5 CCNF ARHGAP11B	7.64e-05	200	97	5	04d95a9102248e98eed069840ea6d3d23a243fd5
Disease	orotic aciduria (implicated_via_orthology)	CAD UMPS	9.62e-06	2	92	2	DOID:0050833 (implicated_via_orthology)
Disease	Congenital hypoplastic anemia	CAD UMPS	9.62e-06	2	92	2	C0949116
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR2 RYR3	2.88e-05	3	92	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR2 RYR3	2.88e-05	3	92	2	DOID:8545 (implicated_via_orthology)
Disease	Acute Erythroblastic Leukemia	CAD UMPS	5.75e-05	4	92	2	C0023440
Disease	Hereditary spherocytosis	CAD UMPS	2.66e-04	8	92	2	C0037889
Disease	Anemia, Sickle Cell	CAD UMPS	4.26e-04	10	92	2	C0002895
Disease	Optic Atrophy	ABHD12 TBCD	4.26e-04	10	92	2	C0029124
Disease	Cooley's anemia	CAD UMPS	6.22e-04	12	92	2	C0002875
Disease	Thalassemia Minor	CAD UMPS	6.22e-04	12	92	2	C0085578
Disease	Thalassemia Intermedia	CAD UMPS	6.22e-04	12	92	2	C0271979
Disease	beta Thalassemia	CAD UMPS	6.22e-04	12	92	2	C0005283
Disease	fatty acid measurement, fetal genotype effect measurement, breast milk measurement	COG3 ZNF804B	7.33e-04	13	92	2	EFO_0005110, EFO_0007959, EFO_0009092
Disease	fatty acid measurement, breast milk measurement, parental genotype effect measurement	COG3 ZNF804B	8.54e-04	14	92	2	EFO_0005110, EFO_0005939, EFO_0009092
Disease	eating disorder, bipolar disorder	RYR2 NALCN	8.54e-04	14	92	2	EFO_0005203, MONDO_0004985
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	HPS5 RABGGTA	8.54e-04	14	92	2	DOID:3753 (implicated_via_orthology)
Disease	Hemoglobin F Disease	CAD UMPS	9.83e-04	15	92	2	C0019025
Disease	fibrinogen measurement, coronary artery disease	DCHS2 ZSCAN26 LIPA UMPS	1.40e-03	154	92	4	EFO_0001645, EFO_0004623
Disease	hydrocephalus (implicated_via_orthology)	STK36 ULK4	1.59e-03	19	92	2	DOID:10908 (implicated_via_orthology)
Disease	red blood cell density measurement	STK36 ATR ST3GAL4 GPRC5A KDM6B FOCAD BAZ1A ULK4 TAF5L	1.71e-03	880	92	9	EFO_0007978
Disease	aspartate aminotransferase measurement	OBSCN PARVB ST3GAL4 ACOX2 LIPA WDR11 WDR41 GCN1 ATG16L2	2.05e-03	904	92	9	EFO_0004736
Disease	Lewy body dementia, Lewy body dementia measurement	PARVB HPS5	2.98e-03	26	92	2	EFO_0006792, EFO_0006799

Protein segments in the cluster

Peptide	Gene	Start	Entry
DHLLGCDLSIASKHI	NAIP	431	Q13075
VLKRLCDLHAIHGIL	ACOX2	571	Q99424
EHPCLVELLSHVLKV	BRAT1	51	Q6PJG6
SLTLSHCVDVVKGLL	ATG16L2	281	Q8NAA4
HLSCVKILLKHGAQV	ASB9	81	Q96DX5
LECIVLHKLHFTLGA	CCNO	216	P22674
AHVDHGKTTLADCLI	EFL1	26	Q7Z2Z2
LHLACASGHVKVVTL	ANKRD20A5P	71	A0PJZ0
SDCIILLLQHGASIH	ANKRD60	266	Q9BZ19
HRLHSGKLCLIILTC	ARMH3	386	Q5T2E6
LRSCKTLTHEIGHIF	AMZ2	246	Q86W34
ILHALCGKLLTLVST	BAZ1A	616	Q9NRL2
CLLAHAVSLTKLVRG	GPRC5A	111	Q8NFJ5
ILLLSCLLADHTVHV	ARHGAP11B	156	Q3KRB8
TKELIAEIGSLSLHC	INTS8	281	Q75QN2
SKSGICRHLHVLIGT	KIR3DL2	331	P43630
ENVKHISCPLLILHA	ABHD12	316	Q8N2K0
TELHCDEKTIIIGHS	RBBP9	61	O75884
VLKDLLVAAIVHCKH	MAB21L4	151	Q08AI8
LHHAAVSGDLTCLKL	ESPNL	141	Q6ZVH7
CHKLIIRHLASDAII	NUP98	1646	P52948
CIHKAGILHRDIKTL	NEK9	166	Q8TD19
CLTLHHLVVEIKGLL	NUDT18	241	Q6ZVK8
EGHLSVLHLCALRSL	SLC2A7	266	Q6PXP3
FCLHLNGKVSHLSLI	HPS5	341	Q9UPZ3
LHGKLESLHGCVQAL	KDM6B	86	O15054
RCHVASLLSLALHGK	PLXNB3	1401	Q9ULL4
HLAIITSFCKGRTLH	KSR1	681	Q8IVT5
TLIICHGLATLVKFH	MARCHF6	346	O60337
QCLLLLEVLGGSHKH	GCN1	146	Q92616
LLEKGQHQTILCVLH	PTPDC1	676	A2A3K4
DLIHESILHKCIKTL	EIF4G2	221	P78344
ILAVCHPDCITTIKH	MACF1	6836	Q9UPN3
LHLLTQEALSIHGVK	ALDH18A1	516	P54886
VDSIHGKNLVAILHL	PARVB	171	Q9HBI1
LLGTHISGTCHELKA	DCHS2	3351	Q6V1P9
EQGTLHLLTLHKVTL	OBSCN	4301	Q5VST9
PLGKCISHLTLHELL	PATL2	416	C9JE40
PFALLHLLHCLLSKS	ATR	886	Q13535
HLLHCLLSKSASVSG	ATR	891	Q13535
KSHCVLLGDAAHAIV	KMO	296	O15229
LLHIVSKCHEEGLDS	DOCK11	896	Q5JSL3
LHKKAISAVHSLLCG	DOCK6	1131	Q96HP0
THKASILHCLGRVLS	CCNF	181	P41002
KCLLSLFRDIGHHLI	CFAP70	376	Q5T0N1
SHIHSLLLCGVLAVL	CFAP70	701	Q5T0N1
HVIHLETLSELCGIL	COG3	416	Q96JB2
SHVALLAKHAIVICN	COPA	501	P53621
ELIILTASHCLHGKE	CYP51A1	206	Q16850
GAHGLLCLLSDHVDK	GRHPR	51	Q9UBQ7
CEHTVLATKILHLLG	COPG2	446	Q9UBF2
VTVLALLGALLKCIH	FAM187B	341	Q17R55
LVSLHLQHCGIAELE	CHADL	451	Q6NUI6
SLETLKTLLALGCHV	RYR2	936	Q92736
LLCHIGVVQHALKKS	CDC27	671	P30260
KITGECSSSIHLLEH	FOCAD	281	Q5VW36
LTVHVLDCKSANLGH	OTOG	2146	Q6ZRI0
LLIILAIGSDLHLHT	OR1N1	41	Q8NGS0
GVTKSTILCLLHLSH	RTTN	1321	Q86VV8
ALCKVLTLHIHLDVQ	TAF5L	186	O75529
IIDLLLHCHSKTVRQ	USP9X	1316	Q93008
TLLLSCLLADHTVHV	ARHGAP11A	156	Q6P4F7
RLAACHSEVLTGKLH	TOGARAM2	516	Q6ZUX3
HSEVLTGKLHDVCLV	TOGARAM2	521	Q6ZUX3
TLKGLALHDILTEIH	RFC5	271	P40937
LHLAHKDLTVLCHLE	RABGGTA	446	Q92696
TCGHLHLVELLIASG	PPP1R16A	146	Q96I34
ITLALHLCDLVHIAG	ST3GAL4	266	Q11206
ALEDHHVISVTGCLL	NKAIN1	126	Q4KMZ8
LLLCCLLKHEDLGHV	HERC2P3	166	Q9BVR0
LLKHEDLGHVALSLV	HERC2P3	171	Q9BVR0
QHGSILMSILKHLLC	STK36	946	Q9NRP7
DGIVLVQCTEHLLKH	CHAT	446	P28329
GCLHSKEHSIKATLI	CLEC2D	21	Q9UHP7
AHAIITLGKLCLQHE	NCAPD3	921	P42695
CGESFIQKLDLIIHH	ZNF182	351	P17025
LNLCLIHERIHTGVK	ZNF20	211	P17024
DCDNHLSKGIIHLVT	ZNF804B	1021	A4D1E1
HKLIALAICKLIHIT	THOC2	376	Q8NI27
TLKTLLALGCHIAHV	RYR3	926	Q15413
CIHCGVVHLTLALLK	ZNF592	801	Q92610
DHSVALLHLEGKSCL	WDR72	536	Q3MJ13
HGIRLHSVCTLSKML	UMPS	166	P11172
CLSGISLHVALKALH	SLC35C2	306	Q9NQQ7
ALCQHLHLTGKIRIA	TSTD2	191	Q5T7W7
LTGIILCHILEGHLE	TTC21A	371	Q8NDW8
LHKCLLCGALSELHV	VCPIP1	466	Q96JH7
LKHGRTVHSLACLLT	CAD	2081	P27708
CLLLHAAGVLLHVSV	ZDHHC24	141	Q6UX98
LIEHASTHTGKKLCE	ZSCAN26	246	Q16670
ICGLRLKDILHLAEH	ZNF792	136	Q3KQV3
CSSLLRKHQLIHLGE	ZNF765	226	Q7L2R6
VPLLKTLDHVLTHGC	TBCD	1041	Q9BTW9
LLHKELSIHSCEVKG	WDR11	506	Q9BZH6
LSLVSLCLLGAKHIE	TRBV14	6	A0A5B0
DHGLVTCSADHLIIL	WDR41	416	Q9HAD4
ISGLHHLHKLGILFC	ULK4	106	Q96C45
VLLTGLHAVADIHCE	YPEL3	66	P61236
SHGTICSLIPNLKHL	KIAA1958	21	Q8N8K9
HVCTHVILKELCGNL	LIPA	246	P38571
HKFELLLVIGTTLHV	NALCN	451	Q8IZF0