Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF14 ZNF799 ZNF699 ZBTB48 ZNF467 ZNF564 ZNF709 ZNF491 ZNF441 ZNF669 ZNF77 ZNF44	7.34e-06	1459	37	12	GO:0000977
GeneOntologyMolecularFunction	damaged DNA binding	ZNF14 ZNF699 ZNF709 RECQL4	1.73e-05	84	37	4	GO:0003684
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF14 ZNF799 ZNF699 ZBTB48 ZNF467 ZNF709 ZNF491 ZNF441 ZNF669 ZNF77 ZNF44	3.27e-05	1412	37	11	GO:0000981
Domain	Znf_C2H2-like	DNAJC21 ZNF14 ZNF799 ZNF318 CPXCR1 ZNF699 ZBTB48 ZNF467 ZNF564 ZNF709 ZNF491 ZNF441 ZNF669 ZNF77 ZNF44	2.13e-12	796	34	15	IPR015880
Domain	ZnF_C2H2	DNAJC21 ZNF14 ZNF799 ZNF318 CPXCR1 ZNF699 ZBTB48 ZNF467 ZNF564 ZNF709 ZNF491 ZNF441 ZNF669 ZNF77 ZNF44	2.63e-12	808	34	15	SM00355
Domain	ZINC_FINGER_C2H2_2	DNAJC21 ZNF14 ZNF799 CPXCR1 ZNF699 ZBTB48 ZNF467 ZNF564 ZNF709 ZNF491 ZNF441 ZNF669 ZNF77 ZNF44	2.57e-11	775	34	14	PS50157
Domain	Znf_C2H2	DNAJC21 ZNF14 ZNF799 CPXCR1 ZNF699 ZBTB48 ZNF467 ZNF564 ZNF709 ZNF491 ZNF441 ZNF669 ZNF77 ZNF44	4.26e-11	805	34	14	IPR007087
Domain	Znf_C2H2/integrase_DNA-bd	DNAJC21 ZNF14 ZNF799 ZNF699 ZBTB48 ZNF467 ZNF564 ZNF709 ZNF491 ZNF441 ZNF669 ZNF77 ZNF44	1.04e-10	694	34	13	IPR013087
Domain	zf-C2H2_6	ZNF14 ZNF799 ZNF699 ZBTB48 ZNF467 ZNF564 ZNF709 ZNF669 ZNF77 ZNF44	1.43e-10	314	34	10	PF13912
Domain	ZINC_FINGER_C2H2_1	DNAJC21 ZNF14 ZNF799 ZNF699 ZBTB48 ZNF467 ZNF564 ZNF709 ZNF491 ZNF441 ZNF669 ZNF77 ZNF44	4.18e-10	777	34	13	PS00028
Domain	-	ZNF14 ZNF799 ZNF699 ZBTB48 ZNF467 ZNF564 ZNF709 ZNF491 ZNF441 ZNF669 ZNF77 ZNF44	1.27e-09	679	34	12	3.30.160.60
Domain	zf-C2H2	ZNF14 ZNF799 ZNF699 ZBTB48 ZNF467 ZNF564 ZNF709 ZNF491 ZNF441 ZNF669 ZNF77 ZNF44	1.60e-09	693	34	12	PF00096
Domain	KRAB	ZNF14 ZNF799 ZNF699 ZNF564 ZNF709 ZNF441 ZNF669 ZNF77 ZNF44	1.09e-08	358	34	9	PS50805
Domain	KRAB	ZNF14 ZNF799 ZNF699 ZNF564 ZNF709 ZNF441 ZNF669 ZNF77 ZNF44	1.09e-08	358	34	9	PF01352
Domain	KRAB	ZNF14 ZNF799 ZNF699 ZNF564 ZNF709 ZNF441 ZNF669 ZNF77 ZNF44	1.41e-08	369	34	9	SM00349
Domain	KRAB	ZNF14 ZNF799 ZNF699 ZNF564 ZNF709 ZNF441 ZNF669 ZNF77 ZNF44	1.44e-08	370	34	9	IPR001909
Domain	DCX	DCLK2 DCLK1	4.80e-05	6	34	2	SM00537
Domain	DCX	DCLK2 DCLK1	6.72e-05	7	34	2	PF03607
Domain	-	DCLK2 DCLK1	6.72e-05	7	34	2	3.10.20.230
Domain	DC	DCLK2 DCLK1	8.95e-05	8	34	2	PS50309
Domain	Doublecortin_dom	DCLK2 DCLK1	8.95e-05	8	34	2	IPR003533
Domain	ZnF_U1	DNAJC21 ZNF318	1.27e-03	29	34	2	SM00451
Domain	Znf_U1	DNAJC21 ZNF318	1.27e-03	29	34	2	IPR003604
Domain	TBC	TBC1D19 TBC1D4	3.59e-03	49	34	2	SM00164
Domain	RabGAP-TBC	TBC1D19 TBC1D4	4.18e-03	53	34	2	PF00566
Domain	TBC_RABGAP	TBC1D19 TBC1D4	4.50e-03	55	34	2	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D19 TBC1D4	4.50e-03	55	34	2	IPR000195
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	DCLK2 DCLK1	6.99e-03	69	34	2	IPR020636
Pathway	REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS	ZNF14 ZNF699 ZNF709	1.28e-04	56	25	3	MM17236
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF799 ZNF699 ZNF564 ZNF441 ZNF669 ZNF77 ZNF44	8.30e-10	181	37	7	37372979
Pubmed	Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation.	DCLK2 DCLK1	1.10e-06	2	37	2	23385585
Pubmed	Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms.	DCLK2 DCLK1	3.30e-06	3	37	2	26526391
Pubmed	Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice.	DCLK2 DCLK1	3.30e-06	3	37	2	18075264
Pubmed	The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV.	ZNF14 ZNF709	3.30e-06	3	37	2	30709743
Pubmed	The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades doublecortin proteins to constrain neuronal dendritogenesis.	DCLK2 DCLK1	6.60e-06	4	37	2	33199366
Pubmed	Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.	NGF DCLK1	1.65e-05	6	37	2	23535911
Pubmed	Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV.	DCLK2 DCLK1	1.65e-05	6	37	2	16684769
Pubmed	An evolutionarily conserved nested gene pair - Mab21 and Lrba/Nbea in metazoan.	DCLK2 DCLK1	1.65e-05	6	37	2	19482073
Pubmed	Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration.	DCLK2 DCLK1	3.95e-05	9	37	2	16387639
Pubmed	The doublecortin gene family and disorders of neuronal structure.	DCLK2 DCLK1	4.93e-05	10	37	2	20236041
Pubmed	The evolving doublecortin (DCX) superfamily.	DCLK2 DCLK1	4.93e-05	10	37	2	16869982
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	DCLK2 TBC1D4 DCLK1	3.78e-04	132	37	3	16944949
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF14 ZNF44	5.02e-04	31	37	2	2288909
Pubmed	The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling.	DCLK2 DCLK1	5.35e-04	32	37	2	31315048
Pubmed	Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.	TBC1D19 TBC1D4	9.67e-04	43	37	2	19077034
Pubmed	Functional dissection of Rab GTPases involved in primary cilium formation.	TBC1D19 RAB15	9.67e-04	43	37	2	17646400
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SFMBT1 NEK1 ZNF318 TBC1D4	9.93e-04	418	37	4	34709266
Pubmed	Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve.	NGF LFNG	1.01e-03	44	37	2	37494420
Cytoband	19p13.2	ZNF799 ZNF699 ZNF564 ZNF709 ZNF491 ZNF441 ZNF44	6.35e-10	229	37	7	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF14 ZNF799 ZNF699 ZNF564 ZNF709 ZNF491 ZNF441 ZNF77 ZNF44	1.10e-08	797	37	9	chr19p13
Cytoband	8q24.3	TMEM249 RECQL4	3.78e-03	113	37	2	8q24.3
Cytoband	7q34	MOXD2P KIAA1549	8.06e-03	167	37	2	7q34
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF14 ZNF799 ZNF318 ZNF699 ZBTB48 ZNF467 ZNF564 ZNF709 ZNF491 ZNF441 ZNF669 ZNF77 ZNF44	3.54e-12	718	26	13	28
GeneFamily	Doublecortin superfamily	DCLK2 DCLK1	8.89e-05	10	26	2	1369
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB48 BTBD7	1.58e-02	134	26	2	861
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_500	SFMBT1 DNAJC21 DDIAS NEK1 ZNF318 TDH	3.55e-05	385	35	6	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_500
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NGF KIAA1549 RASGRP4 ZNF318	1.05e-05	165	37	4	e2aebb2fe197151e019371b8960f76f0c2386f08
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NGF KIAA1549 RASGRP4 ZNF318	1.05e-05	165	37	4	b087771499aeb31cc4a338d2d0a9392a4ec1ac45
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NGF KIAA1549 RASGRP4 ZNF318	1.05e-05	165	37	4	d8f8b088fd28a6b9dbd6b51bcaee42000e963321
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DDIAS RASGRP4 TBC1D4 BTBD7	1.26e-05	173	37	4	28c98a9a54aa2cfa67464db4f628c9357ad185b9
Disease	dyslexia (implicated_via_orthology)	DCLK2 DCLK1	1.45e-06	2	36	2	DOID:4428 (implicated_via_orthology)
Disease	Combined immunodeficiency	MALT1 RECQL4	1.15e-03	41	36	2	C0494261
Disease	optic cup area measurement	RFLNA DCLK1	2.14e-03	56	36	2	EFO_0006940
Disease	Calcium channel blocker use measurement	TBC1D19 ZNF318 LFNG	2.22e-03	213	36	3	EFO_0009930
Disease	carnitine measurement	SFMBT1 ZNF318	3.90e-03	76	36	2	EFO_0010469
Disease	visceral adipose tissue measurement, body mass index	DCLK2 RFLNA	5.07e-03	87	36	2	EFO_0004340, EFO_0004765

Protein segments in the cluster

Peptide	Gene	Start	Entry
SERRHHSPSERSHCS	C2orf16	1746	Q68DN1
SFTHHERAITFRRPS	CPXCR1	186	Q8N123
CRFTDNEFHSSHIST	RAB15	26	P59190
HHGRTCYSRFSRESE	KIAA1107	966	Q9UPP5
ASHFHTFRSAFRTSE	KIAA1549	226	Q9HCM3
SAAGRHRAFSTCSSH	OR10W1	221	Q8NGF6
SVEADPSRFRSIHCH	LFNG	351	Q8NES3
RSSSHPIFHRGEFSV	NGF	121	P01138
QCSPEESFAFRSHSH	NEK1	1006	Q96PY6
RTPDAFISSFAHHAS	MALT1	781	Q9UDY8
PSPTHSAHCSFYRTR	DCLK1	31	O15075
PSPAHSAHCSFYRTR	DCLK2	46	Q8N568
DSRHSRTCSPTPHFQ	DDIAS	741	Q8IXT1
HTFHEVTFRKPTFCD	RASGRP4	541	Q8TDF6
TCHSEFPSRNKLFDH	DNAJC21	486	Q5F1R6
IPSAFCFLSHDHGRT	NEU2	191	Q9Y3R4
QSCRHSIPVFCHSSF	F11	281	P03951
RSFSYPCNHSLFHSR	BTBD7	791	Q9P203
TTMHFSRPFRSCDPH	MOXD2P	126	A6NHM9
RRTFQAFHSVAFPSC	RECQL4	1071	O94761
HNRTHTGERPFSCEF	ZBTB48	511	P10074
AFDCPSSFQIHERTH	ZNF564	401	Q8TBZ8
AFSCPSYFREHVRTH	ZNF77	276	Q15935
SCYSSFRDHVRTHTG	ZNF77	306	Q15935
SFDSPSSFRRHERIH	ZNF441	511	Q8N8Z8
FPKHARSTFRTTLHC	RFLNA	171	Q6ZTI6
SCFARSSRSAIRHSP	SOGA1	1386	O94964
AFPDYSSCLRHERTH	ZNF799	261	Q96GE5
SDSPQFRRRAHTFSH	TBC1D4	631	O60343
AFSCSRSFRIHERTH	ZNF709	596	Q8N972
CPSSFHRHERTHTGE	ZNF491	226	Q8N8L2
ENHARRSFVCHADSP	SFMBT1	316	Q9UHJ3
FSCPSSFRAHVRDHT	ZNF699	456	Q32M78
FSCPSSFRRHVRSHT	ZNF699	596	Q32M78
RFFFRLHSISSHPSG	TBC1D19	396	Q8N5T2
DHCFSADRRSSDPHR	ZNF318	661	Q5VUA4
AFSRSSFCREHERTH	ZNF44	616	P15621
AHSRAHSGARPFACA	ZNF467	476	Q7Z7K2
FHSASFSDTDHPRVL	TDH	41	Q8IZJ6
RLALSSDAHGRCFFH	TMEM249	141	Q2WGJ8
RFSCSFKTHERTHTG	ZNF669	316	Q96BR6
SCPTYFRTHERTHTG	ZNF14	261	P17017