Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD2 CHD3 CHD4 SMARCA2 SMARCA4

3.04e-06371235GO:0140658
GeneOntologyMolecularFunctionX11-like protein binding

CLSTN2 CLSTN1

1.12e-0431232GO:0042988
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

SETX CHD2 CHD3 CHD4 SMARCA2 SMARCA4

1.36e-041271236GO:0008094
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

SETX POLG CHD2 CHD3 CHD4 REV3L SMARCA2 SMARCA4

2.22e-042621238GO:0140097
GeneOntologyMolecularFunctionneuroligin family protein binding

NRXN3 NRXN2

3.72e-0451232GO:0097109
GeneOntologyMolecularFunctionhelicase activity

SETX CHD2 CHD3 CHD4 SMARCA2 SMARCA4

4.43e-041581236GO:0004386
DomainSNF2_N

CHD2 CHD3 CHD4 SMARCA2 SMARCA4

1.84e-06321215IPR000330
DomainSNF2_N

CHD2 CHD3 CHD4 SMARCA2 SMARCA4

1.84e-06321215PF00176
Domain-

NBEAL1 CLSTN2 CLSTN1 THBS1 NRXN3 NRXN2

3.55e-059512162.60.120.200
DomainGln-Leu-Gln_QLQ

SMARCA2 SMARCA4

4.16e-0521212IPR014978
DomainSnAC

SMARCA2 SMARCA4

4.16e-0521212PF14619
DomainQLQ

SMARCA2 SMARCA4

4.16e-0521212SM00951
DomainQLQ

SMARCA2 SMARCA4

4.16e-0521212PS51666
DomainSnAC

SMARCA2 SMARCA4

4.16e-0521212SM01314
DomainSnAC

SMARCA2 SMARCA4

4.16e-0521212IPR029295
DomainQLQ

SMARCA2 SMARCA4

4.16e-0521212PF08880
DomainCalsyntenin

CLSTN2 CLSTN1

1.24e-0431212IPR026914
DomainCHD_N

CHD3 CHD4

1.24e-0431212IPR012958
DomainCHD_C2

CHD3 CHD4

1.24e-0431212IPR012957
DomainCHDCT2

CHD3 CHD4

1.24e-0431212PF08074
DomainCHDNT

CHD3 CHD4

1.24e-0431212PF08073
DomainDUF1086

CHD3 CHD4

1.24e-0431212IPR009462
DomainDUF1087

CHD3 CHD4

1.24e-0431212IPR009463
DomainDUF1087

CHD3 CHD4

1.24e-0431212PF06465
DomainDUF1086

CHD3 CHD4

1.24e-0431212PF06461
DomainDUF1087

CHD3 CHD4

1.24e-0431212SM01147
DomainDUF1086

CHD3 CHD4

1.24e-0431212SM01146
DomainHSA

SMARCA2 SMARCA4

2.48e-0441212SM00573
DomainHSA

SMARCA2 SMARCA4

2.48e-0441212PS51204
DomainHSA_dom

SMARCA2 SMARCA4

2.48e-0441212IPR014012
DomainHSA

SMARCA2 SMARCA4

2.48e-0441212PF07529
DomainChromo_domain

CHD2 CHD3 CHD4

4.86e-04241213IPR023780
DomainSCAN_BOX

ZSCAN31 ZFP69 ZSCAN32 ZKSCAN3

5.43e-04581214PS50804
DomainBRK

SMARCA2 SMARCA4

6.14e-0461212SM00592
DomainBRK_domain

SMARCA2 SMARCA4

6.14e-0461212IPR006576
DomainBRK

SMARCA2 SMARCA4

6.14e-0461212PF07533
DomainChromo

CHD2 CHD3 CHD4

6.18e-04261213PF00385
DomainHelicase_C

CHD2 CHD3 CHD4 SMARCA2 SMARCA4

6.59e-041071215PF00271
DomainHELICc

CHD2 CHD3 CHD4 SMARCA2 SMARCA4

6.59e-041071215SM00490
DomainHelicase_C

CHD2 CHD3 CHD4 SMARCA2 SMARCA4

6.88e-041081215IPR001650
DomainHELICASE_CTER

CHD2 CHD3 CHD4 SMARCA2 SMARCA4

7.17e-041091215PS51194
DomainHELICASE_ATP_BIND_1

CHD2 CHD3 CHD4 SMARCA2 SMARCA4

7.17e-041091215PS51192
DomainDEXDc

CHD2 CHD3 CHD4 SMARCA2 SMARCA4

7.17e-041091215SM00487
DomainHelicase_ATP-bd

CHD2 CHD3 CHD4 SMARCA2 SMARCA4

7.48e-041101215IPR014001
DomainCHROMO_1

CHD2 CHD3 CHD4

7.72e-04281213PS00598
DomainCHROMO_2

CHD2 CHD3 CHD4

7.72e-04281213PS50013
DomainSyndecan

NRXN3 NRXN2

8.56e-0471212PF01034
DomainSyndecan/Neurexin_dom

NRXN3 NRXN2

8.56e-0471212IPR027789
DomainChromodomain-like

CHD2 CHD3 CHD4

1.15e-03321213IPR016197
DomainChromo/shadow_dom

CHD2 CHD3 CHD4

1.26e-03331213IPR000953
DomainCHROMO

CHD2 CHD3 CHD4

1.26e-03331213SM00298
DomainDNA/RNA_helicase_DEAH_CS

CHD2 CHD3 CHD4

1.49e-03351213IPR002464
DomainDEAH_ATP_HELICASE

CHD2 CHD3 CHD4

1.90e-03381213PS00690
DomainConA-like_dom

NBEAL1 CLSTN2 CLSTN1 THBS1 NRXN3 NRXN2

3.05e-032191216IPR013320
DomainWW

PIN1 PIN1P1 UTRN

3.49e-03471213PF00397
DomainNeurexin-like

NRXN3 NRXN2

3.60e-03141212IPR003585
Domain4.1m

NRXN3 NRXN2

3.60e-03141212SM00294
DomainWW

PIN1 PIN1P1 UTRN

3.71e-03481213SM00456
Domainzf-CCCH

MKRN4P U2AF1 RBM27

3.93e-03491213PF00642
DomainEGF

LAMC3 THBS1 HEG1 NRXN3 HMCN1 NRXN2

4.30e-032351216SM00181
DomainWW_DOMAIN_1

PIN1 PIN1P1 UTRN

4.40e-03511213PS01159
DomainWW_DOMAIN_2

PIN1 PIN1P1 UTRN

4.40e-03511213PS50020
DomainWW_dom

PIN1 PIN1P1 UTRN

4.65e-03521213IPR001202
Domainzf-C2H2

TSHZ3 ZNF536 ZSCAN31 ZFP69 ZNF77 ZSCAN32 ZNF37A ZNF641 ZKSCAN3 ZFP2 ZNF646

5.38e-0369312111PF00096
DomainEGF-like_dom

LAMC3 THBS1 HEG1 NRXN3 HMCN1 NRXN2

5.68e-032491216IPR000742
DomainSCAN

ZSCAN31 ZSCAN32 ZKSCAN3

5.73e-03561213SM00431
DomainChromodomain_CS

CHD2 CHD3

5.95e-03181212IPR023779
DomainZnf_CCCH

MKRN4P U2AF1 RBM27

6.32e-03581213IPR000571
DomainLaminin_G

THBS1 NRXN3 NRXN2

6.32e-03581213IPR001791
DomainSCAN

ZSCAN31 ZSCAN32 ZKSCAN3

6.32e-03581213PF02023
DomainSCAN_dom

ZSCAN31 ZSCAN32 ZKSCAN3

6.32e-03581213IPR003309
DomainEGF_1

LAMC3 THBS1 HEG1 NRXN3 HMCN1 NRXN2

6.36e-032551216PS00022
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

GAD1 CASP10 CHD3 CHD4 ZFP69 TFAP2C ZNF77 NCOR1 U2AF1 ZSCAN32 THBS1 ZNF37A SUPT6H PIN1 ZNF641 ZKSCAN3 TNRC6A PLXNA4 SMARCA2 SMARCA4 HDAC10 ZFP2

2.53e-0513878722M734
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

USP34 TSHZ3 ZNF536 DNAJC13 CHD3 CHD4 BCR NCOR1 FASN ZKSCAN3 TNRC6A GEMIN4 UTRN

4.54e-094181261334709266
Pubmed

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

CHD3 CHD4 SMARCA2 SMARCA4

5.31e-0811126410204490
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

USP34 SETX PAK4 BCR FRMD4B TIAM2 NRXN3 NRXN2 RBM27 SUPT6H TNRC6A KCNT1 ZNF646

7.20e-085291261314621295
Pubmed

The contribution of rare and common variants in 30 genes to risk nicotine dependence.

ANKK1 DBH NRXN3 NRXN2

1.60e-0714126425450229
Pubmed

Characterization of the CHD family of proteins.

CHD2 CHD3 CHD4

1.85e-07412639326634
Pubmed

Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.

GAD1 CLSTN2 CLSTN1 NRXN3 NRXN2

1.31e-0652126524613359
Pubmed

Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit.

NRXN3 PTPRD NRXN2

2.57e-068126337591863
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

USP34 PNKP INCENP CHD2 CHD3 CHD4 MED13L TFAP2C NCOR1 FASN RBM27 SUPT6H PIN1 SMARCA2 SMARCA4

4.26e-0610141261532416067
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

USP34 INCENP CHD2 CHD4 FASN SUPT6H SMARCA2 GEMIN4 SMARCA4 SNX9 UTRN HERC5

4.82e-066531261222586326
Pubmed

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.

PNKP CHD3 CHD4 NCOR1 SUPT6H SMARCA2 SMARCA4

4.96e-06183126736129980
Pubmed

A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.

ZNF536 CHD4 CLSTN2 PTPRD

5.46e-0632126423049088
Pubmed

ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF.

THBS1 SMARCA2 SMARCA4

5.47e-0610126323129809
Pubmed

The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex.

ANKRD31 COX11 PNISR PTPRD LNX1

6.64e-0672126533726789
Pubmed

Portal osmopressor mechanism linked to transient receptor potential vanilloid 4 and blood pressure control.

DBH TRPV4

1.30e-052126220385965
Pubmed

The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis.

SMARCA2 SMARCA4

1.30e-05212628670841
Pubmed

Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen.

CHD3 CHD4

1.30e-05212627560064
Pubmed

Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.

SMARCA2 SMARCA4

1.30e-052126223163725
Pubmed

Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development.

SMARCA2 SMARCA4

1.30e-052126223076393
Pubmed

The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD.

SMARCA2 SMARCA4

1.30e-052126215576411
Pubmed

Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.

SMARCA2 SMARCA4

1.30e-052126215240517
Pubmed

Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type.

SMARCA2 SMARCA4

1.30e-052126226564006
Pubmed

SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.

SMARCA2 SMARCA4

1.30e-052126233027072
Pubmed

A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.

SMARCA2 SMARCA4

1.30e-052126223872584
Pubmed

Alterations of the SWI/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma.

SMARCA2 SMARCA4

1.30e-052126223088494
Pubmed

SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.

SMARCA2 SMARCA4

1.30e-052126220333683
Pubmed

SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies.

SMARCA2 SMARCA4

1.30e-052126234812766
Pubmed

Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy.

SMARCA2 SMARCA4

1.30e-052126230478150
Pubmed

The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation.

CHD3 CHD4

1.30e-05212627575689
Pubmed

TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells.

PIN1 TRIM8

1.30e-052126231799391
Pubmed

The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.

SMARCA2 SMARCA4

1.30e-052126225808524
Pubmed

Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation.

SMARCA2 SMARCA4

1.30e-052126219144648
Pubmed

A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells.

TICAM1 TNFAIP3

1.30e-052126215142865
Pubmed

High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer.

SMARCA2 SMARCA4

1.30e-052126229391527
Pubmed

Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model.

SMARCA2 SMARCA4

1.30e-052126237634210
Pubmed

Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.

SMARCA2 SMARCA4

1.30e-05212628208605
Pubmed

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.

SMARCA2 SMARCA4

1.30e-052126211163203
Pubmed

Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes.

SMARCA2 SMARCA4

1.30e-052126212620226
Pubmed

BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.

SMARCA2 SMARCA4

1.30e-052126227039070
Pubmed

Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage.

SMARCA2 SMARCA4

1.30e-052126229848589
Pubmed

Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein.

SMARCA2 SMARCA4

1.30e-05212629603422
Pubmed

SWI/SNF gene variants and glioma risk and outcome.

SMARCA2 SMARCA4

1.30e-052126223276717
Pubmed

Differential Expression of SWI/SNF Chromatin Remodeler Subunits Brahma and Brahma-Related Gene During Drug-Induced Liver Injury and Regeneration in Mouse Model.

SMARCA2 SMARCA4

1.30e-052126227097303
Pubmed

SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.

SMARCA2 SMARCA4

1.30e-052126228038711
Pubmed

Proinflammatory stimuli engage Brahma related gene 1 and Brahma in endothelial injury.

SMARCA2 SMARCA4

1.30e-052126223963727
Pubmed

SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level.

SMARCA2 SMARCA4

1.30e-052126212493776
Pubmed

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.

SMARCA2 SMARCA4

1.30e-052126231375262
Pubmed

Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers.

SMARCA2 SMARCA4

1.30e-052126217075831
Pubmed

The human PIN1 peptidyl-prolyl cis/trans isomerase gene maps to human chromosome 19p13 and the closely related PIN1L gene to 1p31.

PIN1 PIN1P1

1.30e-05212629299231
Pubmed

Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.

SMARCA2 SMARCA4

1.30e-052126232855269
Pubmed

Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.

SMARCA2 SMARCA4

1.30e-052126222721696
Pubmed

Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter.

SMARCA2 SMARCA4

1.30e-052126218508913
Pubmed

Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling.

SMARCA2 SMARCA4

1.30e-052126211719516
Pubmed

DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes.

SMARCA2 SMARCA4

1.30e-052126228706277
Pubmed

[Expression of BRG1 and BRM proteins in prostatic cancer].

SMARCA2 SMARCA4

1.30e-052126221092585
Pubmed

SWI/SNF Complex-deficient Undifferentiated/Rhabdoid Carcinomas of the Gastrointestinal Tract: A Series of 13 Cases Highlighting Mutually Exclusive Loss of SMARCA4 and SMARCA2 and Frequent Co-inactivation of SMARCB1 and SMARCA2.

SMARCA2 SMARCA4

1.30e-052126226551623
Pubmed

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.

SMARCA2 SMARCA4

1.30e-052126219458193
Pubmed

The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation.

SMARCA2 SMARCA4

1.30e-052126234289068
Pubmed

SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.

SMARCA2 SMARCA4

1.30e-052126234518526
Pubmed

SMARCA family of genes.

SMARCA2 SMARCA4

1.30e-052126232312722
Pubmed

Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.

SMARCA2 SMARCA4

1.30e-052126226356327
Pubmed

Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development.

CHD3 CHD4

1.30e-052126235568926
Pubmed

Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.

SMARCA2 SMARCA4

1.30e-052126212566296
Pubmed

Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen.

CHD3 CHD4

1.30e-05212628843877
Pubmed

SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.

SMARCA2 SMARCA4

1.30e-052126231406271
Pubmed

Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits.

SMARCA2 SMARCA4

1.30e-052126229273066
Pubmed

Human Melanoma cells over-express extracellular matrix 1 (ECM1) which is regulated by TFAP2C.

ECM1 TFAP2C

1.30e-052126224023917
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

ZNF536 CHD3 NCOR1 SMARCA2 SMARCA4

1.33e-0583126528794006
Pubmed

Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1.

CHD4 PIN1 SMARCA2 SMARCA4

1.36e-0540126434585037
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

CHD2 CHD3 CHD4 SMARCA2 SMARCA4 HDAC10

2.42e-05157126630186101
Pubmed

Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.

NCOR1 SMARCA2 SMARCA4

3.04e-0517126319183483
Pubmed

TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.

CHD4 SMARCA2 SMARCA4

3.64e-0518126328068325
Pubmed

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

SPHK2 MANBA REV3L MST1 FCGR2A MICB LSP1 TNFAIP3

3.70e-05342126823128233
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

TSHZ3 CHD3 CHD4 SMARCA2 SMARCA4

3.80e-05103126532744500
Pubmed

Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx.

NRXN3 NRXN2

3.90e-053126238891114
Pubmed

DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.

SMARCA2 SMARCA4

3.90e-053126230287812
Pubmed

Identification of a novel ANKK1 and other dopaminergic (DRD2 and DBH) gene variants in migraine susceptibility.

ANKK1 DBH

3.90e-053126222875483
Pubmed

The calsyntenins--a family of postsynaptic membrane proteins with distinct neuronal expression patterns.

CLSTN2 CLSTN1

3.90e-053126212498782
Pubmed

Polymorphisms in the DBH and DRD2 gene regions and smoking behavior.

ANKK1 DBH

3.90e-053126216032443
Pubmed

The mouse Jhy gene regulates ependymal cell differentiation and ciliogenesis.

CDH2 JHY

3.90e-053126229211732
Pubmed

alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.

NRXN3 NRXN2

3.90e-053126216406382
Pubmed

Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.

USP34 PIN1

3.90e-053126238167292
Pubmed

BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2.

SMARCA2 SMARCA4

3.90e-053126215034933
Pubmed

Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.

NRXN3 NRXN2

3.90e-053126231005376
Pubmed

Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability.

CHD2 CDH2

3.90e-053126231704914
Pubmed

The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling.

CHD4 SMARCA4

3.90e-053126222290435
Pubmed

The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development.

CHD3 CHD4

3.90e-053126232658897
Pubmed

A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus.

SMARCA2 SMARCA4

3.90e-053126212044884
Pubmed

SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development.

SMARCA2 SMARCA4

3.90e-053126221518954
Pubmed

Characterization of mammary tumors from Brg1 heterozygous mice.

SMARCA2 SMARCA4

3.90e-053126217637742
Pubmed

Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.

NRXN3 NRXN2

3.90e-053126226446217
Pubmed

Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

NRXN3 NRXN2

3.90e-053126211944992
Pubmed

Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.

NRXN3 NRXN2

3.90e-053126233058888
Pubmed

Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.

NRXN3 NRXN2

3.90e-053126217035546
Pubmed

Neurexins: three genes and 1001 products.

NRXN3 NRXN2

3.90e-05312629448462
Pubmed

Deletion of α-neurexin II results in autism-related behaviors in mice.

NRXN3 NRXN2

3.90e-053126225423136
Pubmed

Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.

NRXN3 NRXN2

3.90e-053126234133920
Pubmed

Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models.

SMARCA2 SMARCA4

3.90e-053126228292935
Pubmed

Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma.

SMARCA2 SMARCA4

3.90e-053126236464671
Pubmed

The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.

NRXN3 NRXN2

3.90e-053126230858964
Pubmed

Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.

NRXN3 NRXN2

3.90e-053126228013231
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

TSHZ3 ZNF536 ZSCAN31 ZFP69 ZNF77 ZSCAN32 ZNF37A ZNF641 ZKSCAN3 ZFP2 ZNF646

3.85e-04718821128
GeneFamilyPHD finger proteins|NuRD complex

CHD3 CHD4

1.30e-03128221305
CoexpressionGSE6269_FLU_VS_STREP_PNEUMO_INF_PBMC_UP

SETX CHD4 IFIT1 RFWD3 HEG1 SMARCA4 HERC5

1.79e-051701257M5657
CoexpressionGRYDER_PAX3FOXO1_ENHANCERS_IN_TADS

TSHZ3 SETX CACUL1 COX11 CHD2 MED13L ITPKB ZNF77 PTPRD SMARCA2 MIOS SMARCA4 TNFAIP3 BCAR3 QKI SNX9

2.52e-05100912516M157
CoexpressionROETH_TERT_TARGETS_UP

IFIT1 HEG1 HERC5

3.71e-05141253M18660
CoexpressionGSE14000_UNSTIM_VS_4H_LPS_DC_UP

SPHK2 TMEM94 BCR ZNF77 MYG1 ZNF641 SMARCA4

4.60e-051971257M3345
CoexpressionGSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP

MANBA MFHAS1 CHD2 CHD3 TRIM8 HDAC10 SNX9

4.75e-051981257M9119
CoexpressionGSE24574_BCL6_HIGH_VS_LOW_TFH_CD4_TCELL_UP

USP34 CLSTN1 PNISR ITPKB FASN HEG1 TNFAIP3

4.90e-051991257M8324
CoexpressionGSE42021_TCONV_PLN_VS_CD24HI_TCONV_THYMUS_DN

CLSTN1 BCR IFIT1 MISP PNMA8A SMARCA2 HERC5

4.90e-051991257M9599
CoexpressionGRYDER_PAX3FOXO1_ENHANCERS_KO_DOWN

TSHZ3 CACUL1 COX11 ITPKB ZNF77 SMARCA2 MIOS TNFAIP3 QKI SNX9

4.92e-0543812510M227
CoexpressionGSE28726_ACT_CD4_TCELL_VS_ACT_VA24NEG_NKTCELL_DN

USP34 CHD3 PNISR ITPKB FASN HEG1 TNFAIP3

5.06e-052001257M8306
CoexpressionGSE24574_BCL6_HIGH_TFH_VS_TFH_CD4_TCELL_DN

USP34 CHD3 CLSTN1 PNISR ITPKB FASN HEG1

5.06e-052001257M8331
CoexpressionGSE27786_LSK_VS_CD4_TCELL_DN

SPHK2 SETX MFHAS1 DBH TNRC6A LSP1 JHY

5.06e-052001257M4747
CoexpressionKOINUMA_TARGETS_OF_SMAD2_OR_SMAD3

GAD1 POLG CHD3 CLSTN1 BCR TFAP2C MISP THBS1 MELTF MSANTD3 TRIM8 MIOS BCAR3 QKI

5.13e-0584312514M2356
CoexpressionHOFT_CD4_POSITIVE_ALPHA_BETA_MEMORY_T_CELL_BCG_VACCINE_AGE_18_45YO_56D_TOP_100_DEG_AFTER_IN_VITRO_RE_STIMULATION_DN

MFHAS1 TMEM94 IFIT1 THBS1

7.50e-05471254M40911
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

CHD4 RFWD3 NCOR1 PTPRD RBM27 TNRC6A TRIM8 SMARCA2 GOLIM4 LSP1

8.37e-0546712510M1347
CoexpressionHOEBEKE_LYMPHOID_STEM_CELL_UP

USP34 CHD3 MED13L SMARCA4 TNFAIP3

1.03e-04971255M14698
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

CHD4 RFWD3 NCOR1 PTPRD RBM27 TNRC6A TRIM8 SMARCA2 GOLIM4 LSP1

1.12e-0448412510MM999
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#2_top-relative-expression-ranked_1000

DNAJC13 NBEAL1 CHD2 PNISR FRMD4B HEG1 TNRC6A UTRN

2.61e-052101208gudmap_developingGonad_e18.5_ovary_1000_k2
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_1000

DNAJC13 NBEAL1 CHD2 CLSTN2 PNISR FRMD4B HEG1 CDH2 UTRN

2.69e-052751209gudmap_developingGonad_e14.5_ epididymis_1000_k3
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#3_top-relative-expression-ranked_500

DNAJC13 CHD2 PNISR FRMD4B TFAP2C HEG1 UTRN

3.67e-051611207gudmap_developingGonad_e12.5_ovary_k3_500
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_1000

GAD1 DNAJC13 NBEAL1 CHD2 ECM1 PNISR FRMD4B HEG1 NRXN3 ZKSCAN3 TNRC6A SMARCA2 RBM46 LSP1 UTRN

3.97e-0579012015gudmap_developingGonad_e16.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#3_top-relative-expression-ranked_1000

DNAJC13 NBEAL1 CHD2 PNISR FRMD4B HEG1 ZKSCAN3 UTRN

4.26e-052251208gudmap_developingGonad_e14.5_ ovary_1000_k3
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_1000

DNAJC13 NBEAL1 CHD2 CLSTN2 ECM1 PNISR FRMD4B HEG1 ZKSCAN3 TNRC6A SMARCA2 SMARCA4 RBM46 CDH2 UTRN

4.65e-0580112015gudmap_developingGonad_e14.5_ epididymis_1000
CoexpressionAtlasDevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#2_top-relative-expression-ranked_1000

DNAJC13 NBEAL1 CHD2 CLSTN2 PNISR FRMD4B HEG1 CDH2 UTRN

9.30e-053231209gudmap_developingGonad_e11.5_ovary + mesonephros_k2_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_500

DNAJC13 CHD2 PNISR FRMD4B TFAP2C ZKSCAN3 SMARCA4 RBM46 QKI UTRN

9.85e-0540312010gudmap_developingGonad_e12.5_epididymis_500
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_500

GAD1 DNAJC13 CHD2 PNISR FRMD4B HEG1 ZKSCAN3 RBM46 LSP1 UTRN

1.05e-0440612010gudmap_developingGonad_e16.5_epididymis_500
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_top-relative-expression-ranked_500

DNAJC13 CHD2 PNISR FRMD4B TFAP2C HEG1 ZKSCAN3 RBM46 QKI UTRN

1.11e-0440912010gudmap_developingGonad_e12.5_ovary_500
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_500

DNAJC13 CHD2 ECM1 PNISR FRMD4B HEG1 ZKSCAN3 RBM46 CDH2 UTRN

1.20e-0441312010gudmap_developingGonad_e14.5_ epididymis_500
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_1000

USP34 DNAJC13 NBEAL1 CHD2 CLSTN2 PNISR FRMD4B THBS1 HEG1 HMCN1 ZKSCAN3 TNRC6A RBM46 UTRN

1.29e-0477812014gudmap_developingGonad_e18.5_ovary_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_500_k-means-cluster#4

ZNF536 FRMD4B NRXN2 QKI CDH2 ZFP2

1.29e-041371206Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_500_K4
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_top-relative-expression-ranked_1000

DNAJC13 NBEAL1 CHD2 PNISR FRMD4B TFAP2C HEG1 ZKSCAN3 SMARCA4 RBM46 QKI DHTKD1 CDH2 UTRN

1.81e-0480412014gudmap_developingGonad_e12.5_ovary_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#4

ZNF536 NRXN2 QKI CDH2 ZFP2

2.26e-04971205Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K4
CoexpressionAtlasdev gonad_e11.5_F_SupCellPrec_Sry_k-means-cluster#2_top-relative-expression-ranked_1000

CHD3 REV3L MED13L FRMD4B HMCN1

2.26e-04971205gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_k2_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_1000_k-means-cluster#4

ZNF536 FRMD4B NRXN3 NRXN2 QKI CDH2 ZFP2

2.95e-042251207Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_1000_K4
ToppCellControl-Control-Lymphocyte-T/NK-NK_activated|Control / Disease, condition lineage and cell class

SETX INCENP IFIT1 ITPKB HEG1 NRXN2 SUPT6H SMARCA2 GOLIM4 UTRN ZFP2

1.09e-111981251176d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP34 SETX CHD2 MED13L PNISR IFIT1 TNFAIP3 QKI UTRN HERC5

2.74e-102001251012f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

USP34 SETX CASP10 IFIT1 FAM171A1 HEG1 HMCN1 UTRN

9.99e-082001258dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

PPP1R12B CHD2 BCR FAM171A1 ZNF37A TRIM8 DHTKD1

6.99e-071771257e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

RGS22 CLSTN2 REV3L MED13L HMCN1 QKI UTRN

9.06e-07184125767164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CHD4 HEG1 HMCN1 SMARCA2 SMARCA4 UTRN SCN3B

1.12e-061901257d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ZNF536 FRMPD1 HEG1 GOLIM4 QKI UTRN

1.29e-0619412576ac759828c41ffa974ee82842162caa959351dd1
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ZNF536 FRMPD1 HEG1 GOLIM4 QKI UTRN

1.29e-0619412575d0b0d8e96f0e0297a4dba70a05d87081a4eb323
ToppCellFibroblast-B_(Myofibroblast)|World / shred on cell class and cell subclass (v4)

ZNF536 THBS1 NRXN3 HMCN1 PLXNA4 GOLIM4 LSP1

1.34e-061951257a8d6416518f226e1ec2d6bdc9d4b90cef5cb1365
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

USP34 CHD2 PNISR SMARCA2 TNFAIP3 UTRN

6.54e-061621256b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-6|TCGA-Liver / Sample_Type by Project: Shred V9

TSHZ3 PPP1R12B RGS22 SIRPB2 CLSTN2 ITPKB

8.33e-061691256e992530776cab922d0360b275fb9cb8bd0017b06
ToppCellfacs-Skin-nan-24m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM1 MISP MELTF TRPV4 DHTKD1 JHY

1.02e-051751256f1166b567bca80dac3abe90c3dc544c831006640
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ZNF536 FRMPD1 ECM1 FRMD4B GOLIM4

1.16e-051791256d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF536 CCDC9B NRXN3 HMCN1 QKI CDH2

1.23e-051811256a436e7e4c36403257ea90160a58ca0d6d7c0cdfc
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENAM HEG1 PLXNA4 SMARCA2 GOLIM4 UTRN

1.23e-0518112564ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Myh4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANKK1 LCT IFIT1 FRMD4B UTRN

1.29e-051071255fc07dd90f280191bd643398eac5c8273651d0925
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

CHD2 IFIT1 THBS1 TNFAIP3 UTRN HERC5

1.31e-0518312568f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SETX CHD4 NCOR1 THBS1 SNX9 UTRN

1.35e-0518412561154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ZNF536 FRMPD1 ECM1 FRMD4B GOLIM4

1.39e-051851256f4ac62009c0ad3346e71b809e17727303c4df153
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

USP34 CHD2 MED13L U2AF1 TNFAIP3 UTRN

1.53e-051881256ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GAD1 MFHAS1 ITPKB FAM171A1 HMCN1 LNX1

1.57e-051891256f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ZNF536 FRMPD1 ECM1 FRMD4B GOLIM4

1.62e-0519012560acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

BCR PKHD1L1 FRMD4B HEG1 NRXN3 HMCN1

1.77e-05193125601c2df9206f1527c578e808978e58196c35e72f5
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

USP34 MANBA MED13L QKI SNX9 UTRN

1.77e-051931256779276e775cb2492e8dd36436295a536084a6415
ToppCellControl-Endothelial-Endothelial-Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CASP10 ITPKB FAM171A1 PTPRD HMCN1 SMARCA2

1.77e-051931256e1d546165dcc2392f540162206852c4717d7306f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ZNF536 FRMPD1 HEG1 GOLIM4 UTRN

1.82e-05194125652aebb0b563e2c2058e7f0554ae870e47692b163
ToppCellNeuron-Postmitotic-Inhibitory_Neuron-MGE2|World / Primary Cells by Cluster

GAD1 ZNF536 REV3L NRXN3 NRXN2 SCN3B

1.82e-051941256b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCellNeuron-Postmitotic-Inhibitory_Neuron-MGE2-10|World / Primary Cells by Cluster

GAD1 ZNF536 REV3L NRXN3 NRXN2 SCN3B

1.82e-05194125681e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCBLD1 CLSTN1 HEG1 HMCN1 QKI SCN3B

1.82e-051941256f159ef8541d75a4e98468947f231bb463bec922c
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ZNF536 FRMPD1 HEG1 GOLIM4 UTRN

1.82e-051941256bd06e2b8d8c06cddf2e4f58849b86e09013acae1
ToppCellMatrixFB-Fibroblast-B_(Myofibroblast)|MatrixFB / shred on cell class and cell subclass (v4)

ZNF536 THBS1 NRXN3 HMCN1 PLXNA4 LSP1

1.93e-05196125638ea0eaf42f95c321ca23570d0d7752980cf00f8
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF536 THBS1 HMCN1 PLXNA4 GOLIM4 LSP1

1.99e-05197125626475b9e4d6bfc0ae818dea13d139888ed7e92f1
ToppCellP03-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ZNF536 THBS1 NRXN3 HMCN1 PLXNA4 LSP1

1.99e-0519712562cec938caf6ffd031cea37277071487e59b2c71c
ToppCellP03-Mesenchymal-myocytic_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ZNF536 THBS1 NRXN3 HMCN1 PLXNA4 LSP1

1.99e-051971256079db904a08743b3c555cb7b3f5fb5c978dde25a
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF536 THBS1 NRXN3 HMCN1 GOLIM4 LSP1

1.99e-0519712569d7a1c7dc70ba5e35645f19f9e056e4fa2494aa0
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF536 THBS1 NRXN3 HMCN1 GOLIM4 LSP1

1.99e-051971256090a251194da3e2806989d9a522588f83f52da7f
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF536 THBS1 NRXN3 HMCN1 GOLIM4 LSP1

1.99e-05197125643b5f8e917506c1717f9311584901b506ffd2c79
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF536 THBS1 HMCN1 PLXNA4 GOLIM4 LSP1

1.99e-051971256155e63b33302a87393ace699b2f6d73abe9c5763
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_2|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

GAD1 TIAM2 NRXN3 NRXN2 CORO7 SCN3B

2.04e-051981256b73b9feb82997b654718aa27f33ca7b454214802
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF536 THBS1 HMCN1 PLXNA4 GOLIM4 LSP1

2.04e-051981256a4005a49cf6709b543994ceb51ecd5dc46197fa9
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

GAD1 ZNF536 PNISR TIAM2 NRXN3 PTPRD

2.04e-051981256de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell(02)_MMP9/10+-(1)_GFP|(02)_MMP9/10+ / shred by cell type by condition

MISP THBS1 TRPV4 TNFAIP3 BCAR3 CDH2

2.10e-051991256448ba982be804007f991d469eca9d885b21ae499
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

PPP1R12B REV3L NCOR1 TRIM8 SMARCA2 UTRN

2.10e-051991256c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-MIR548F2--L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 FRMPD1 ECM1 FRMD4B GOLIM4

2.16e-0520012563cbb01039d1e7635ec4dcdf0223587f7ea3c7b34
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 NRXN3 SMARCA2 QKI HERC5

2.16e-052001256f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCellNeuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2--L1-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 FRMPD1 HEG1 GOLIM4 QKI

2.16e-052001256f268cb1bb047e88913a828614b0a77871f5f8814
ToppCellNeuronal-Inhibitory|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 FRMPD1 FRMD4B HEG1 QKI

2.16e-0520012569ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCellNeuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 FRMPD1 HEG1 GOLIM4 QKI

2.16e-0520012565ff9ac97ef970b3b74ebb07f62a0a1f4176a10b4
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-MIR548F2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 FRMPD1 ECM1 FRMD4B GOLIM4

2.16e-05200125697a010a1b6d551239cf6ea5a43319fb413ff180e
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 NRXN3 SMARCA2 QKI HERC5

2.16e-05200125670a06fd7fb8de2c8ec3e3182e4476ced049daeae
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 FRMPD1 HEG1 QKI UTRN

2.16e-052001256862db57d043bdf3cb059fbfc8b29bc1eafdf64ec
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

CHD4 NRXN3 NRXN2 PLXNA4 TRIM8 SCN3B

2.16e-052001256c92e4fc0442404481fcac623d691dae6215b852d
ToppCellNeuronal-Inhibitory-iA-iA_2(LAMP5)|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 FRMPD1 HEG1 GOLIM4 QKI

2.16e-052001256e90155498397524b812c46f2412320230b445bb6
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR--L1|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 FRMPD1 HEG1 QKI UTRN

2.16e-052001256a91345f268f13170c27309333603eb82400c9947
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-MIR548F2|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 FRMPD1 ECM1 FRMD4B GOLIM4

2.16e-0520012568ccf2dbbe34b26fbf2bbef1e64b4ae636edd6672
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SETX CASP10 IFIT1 FAM171A1 HEG1 UTRN

2.16e-052001256a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 NRXN3 SMARCA2 QKI HERC5

2.16e-0520012561639982d9d994918f7912d12d9d7cfcbc9da4145
ToppCellNeuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 FRMPD1 HEG1 GOLIM4 QKI

2.16e-0520012567345cc7dc24b9174541a3e68ecac8c4c092be400
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR-|Neuronal / cells hierarchy compared to all cells using T-Statistic

GAD1 ZNF536 FRMPD1 HEG1 QKI UTRN

2.16e-052001256d416a7be1a4e6232fb58a9687774da24821f1fdd
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / Treatment groups by lineage, cell group, cell type

BCR FRMD4B HEG1 HMCN1 SMARCA2 GOLIM4

2.16e-052001256b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

BCR FRMD4B TIAM2 HEG1 HMCN1 GOLIM4

2.16e-052001256b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons|GW23 / Sample Type, Dataset, Time_group, and Cell type.

GAD1 TSHZ3 ZNF536 NRXN3 NRXN2 CDH2

2.16e-052001256c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Hpse_Sema3c|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LCT IFIT1 FRMD4B GOLIM4 UTRN

2.44e-051221255eae9d94f8510ac0f434942451d55c7260977b178
ToppCellE18.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

GAD1 ATG9B ECM1 NRXN3 PLXNA4

4.26e-051371255b553958e7e6dcd887d860e34d3983cbb85cefaa6
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-OPC_related|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CCDC9B RGS22 ECM1 ITPKB QSOX1

5.05e-051421255d2d150e3019a5b7b143e50b1c1c2b6764abf36bf
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-OPC_related-Oligodendrocyte/OPC|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CCDC9B RGS22 ECM1 ITPKB QSOX1

5.05e-05142125543e72e4b9ae33768672ef90c8bbfd2ca1818c746
ToppCellNS-critical-d_16-33-Myeloid-Monocyte-derived_Macrophage|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAJC13 POLG IFIT1 FCGR2A HERC5

7.19e-051531255859de35b24c5d7d73be1c213b90b43362ee2e0eb
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GAD1 ATG9B IFIT1 FRMD4B UTRN

9.15e-051611255dccb61d5e17a8f1c6d1fc146ee389f567659a0f0
ToppCellfacs-Thymus-Epithelium-3m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DBH TEKT5 TFAP2C MISP ASB11

9.42e-0516212553dc39db0d5f6f3d7bcc312a6bce7aaeb914138d1
ToppCellfacs-Thymus-Epithelium-3m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DBH TEKT5 TFAP2C MISP ASB11

9.42e-0516212550a7138266054ea5954649c8b61ef93905d56b068
ToppCellfacs-Thymus-Epithelium-3m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DBH TEKT5 TFAP2C MISP ASB11

9.42e-05162125525323785dd33337bcefd05958a4a1a208a9ceb04
ToppCellcontrol-Epithelial-Ionocyte|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ZSCAN31 PPP1R12B ENAM THBS1 CDH2

1.03e-0416512555cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLSTN2 LCT RPTN PLXNA4 SCN3B

1.09e-0416712553dfec2fcc36caa6e394efae5e540a6fa28759977
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLSTN2 LCT RPTN PLXNA4 SCN3B

1.09e-04167125595b3b5ba3414729f0460a26a0deca48de0cbe33e
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLSTN2 LCT RPTN PLXNA4 SCN3B

1.09e-0416712559480739587d51e67a281778b9bddd7b5ffc3ad92
ToppCellcontrol-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ZSCAN31 PPP1R12B ENAM THBS1 CDH2

1.12e-041681255327b02f19f4a8607c033203824fdc60a1254331f
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF536 NRXN3 TRPV4 BCAR3 CDH2

1.12e-04168125595dc690c1987b05685d36e6bb20eb79308696e30
ToppCell343B-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

FRMPD1 ENAM ZKSCAN3 PLXNA4 DHTKD1

1.15e-041691255632aa3ab39ec87bafcefec6cddf71129a054d3b0
ToppCellFrontal_cortex-Neuronal-Inhibitory|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

GAD1 ZNF536 ATG9B NRXN3 TNRC6A

1.15e-04169125578eb70dd916724e476eabccf18fb7fcec4210308
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATG9B FAM171A1 HEG1 NRXN3 TRPV4

1.15e-041691255f086b50791e1c93e253eb5e8d6c4bf617b1416c3
ToppCell356C-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

CDC20B CHD3 TIAM2 NRXN2 FOXD4

1.18e-041701255513d9036aa41d4d902da8baa66a66206abb6f3b0
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GAD1 ATG9B IFIT1 FRMD4B UTRN

1.18e-0417012558ab67e2b6e30fdf9e9a2c02e31d4df34e751a3ed
ToppCellfacs|World / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CLSTN1 ECM1 QSOX1 HEG1 SNX9

1.21e-041711255bb71e816dde44fda6af0ad98d979be9f8740fda6
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD31 FRMPD1 DCBLD1 LAMC3 SCN3B

1.21e-041711255b73a365ab3743d1fb7195abfbd76ef779f542cc2
ToppCellfacs|World / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLSTN1 ECM1 QSOX1 HEG1 SNX9

1.21e-0417112555bcb96ed7fc15548f2dc9cf47482f890640cb39c
ToppCellfacs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCBLD1 PKHD1L1 HEG1 NRXN3 HMCN1

1.25e-041721255f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCellfacs-Heart-LV-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCBLD1 PKHD1L1 HEG1 NRXN3 HMCN1

1.25e-0417212556ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD1 ZNF536 FRMPD1 ECM1 FRMD4B

1.39e-041761255682a1dfcc507ec540f5fadf08e872533ea9f0291
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANKK1 BCR PKHD1L1 NRXN2 UTRN

1.39e-041761255460cb302c5b3d609c65b924e1d4e8ea057a68485
ToppCellE16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ECM1 THBS1 MELTF NRXN2 PLXNA4

1.43e-04177125584591e28482ab62a5ef41e61043eb64912766356
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 ZNF536 LAMC3 REV3L LSP1

1.43e-0417712559ec7f1e64312d26d434b3312b58386715dbad644
ToppCellE16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ECM1 THBS1 MELTF NRXN2 PLXNA4

1.43e-0417712554bc100062891d07cacd10ffba38966cc6302c92f
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF536 NRXN3 TRPV4 BCAR3 CDH2

1.43e-0417712550417460bdb012bc43d7254377fa53d79cdab3f34
ToppCellE16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ECM1 THBS1 MELTF NRXN2 PLXNA4

1.43e-0417712559f3a2adb9cd4f0a059afc87b6e377a9702154bb1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 ZNF536 LAMC3 REV3L LSP1

1.43e-041771255016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCellPND10-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GAD1 IFIT1 THBS1 PLXNA4 JHY

1.46e-0417812559e1f2596fcea5b79cc50b58d83706bb8605e224f
ToppCellPND10-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GAD1 IFIT1 THBS1 PLXNA4 JHY

1.46e-041781255aa659bd283c4dfbe292cd8698bbf6b1999ca3314
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-4|TCGA-Breast / Sample_Type by Project: Shred V9

MFHAS1 TIAM2 FAM171A1 MELTF MSANTD3

1.46e-04178125544b5ba4e8788d3973749a1717e427647ac4c8579
ToppCellPND10-Immune-Immune_Myeloid-Megakaryocyte/Platelet|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GAD1 IFIT1 THBS1 PLXNA4 JHY

1.46e-041781255bf1d273802a4f42e52ea1bd2a0cae2039559c093
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRMPD1 ITPKB FAM171A1 HMCN1 BCAR3

1.50e-041791255666072c0e8448dbaec1683d18368ec2502453f90
DrugBenfluorex hydrochloride [23642-66-2]; Up 200; 10.4uM; MCF7; HT_HG-U133A

USP34 GAD1 ZSCAN31 IFIT1 ITPKB SUPT6H TNFAIP3 HERC5

1.28e-0519412682621_UP
DrugDeoxycorticosterone [64-85-7]; Down 200; 12.2uM; PC3; HT_HG-U133A

SETX TFAP2C THBS1 NRXN3 SMARCA2 QKI UTRN HERC5

1.43e-0519712686758_DN
DrugHydroxytacrine maleate (R,S) [118909-22-1]; Up 200; 12.2uM; PC3; HT_HG-U133A

FRMPD1 CASP10 MELTF HEG1 PTPRD PNMA8A MIOS TNFAIP3

1.48e-0519812686651_UP
DrugPyridoxine hydrochloride [58-56-0]; Down 200; 19.4uM; PC3; HT_HG-U133A

USP34 ZSCAN31 BCR ITPKB NCOR1 HEG1 CDH2 JHY

1.48e-0519812685813_DN
DrugPentoxifylline [6493-05-6]; Up 200; 14.4uM; PC3; HT_HG-U133A

GAD1 CHD3 PNISR BCR HEG1 SMARCA2 TNFAIP3 QKI

1.60e-0520012682127_UP
DiseaseAutism Spectrum Disorders

TSHZ3 LAMC3 CHD2 NRXN3 NRXN2

2.80e-05851225C1510586
Diseaseautism spectrum disorder (implicated_via_orthology)

TSHZ3 LAMC3 CHD2 SCAMP3 NRXN3 NRXN2

4.18e-051521226DOID:0060041 (implicated_via_orthology)
Diseaseelectrodermal activity measurement

NRXN3 TNRC6A

5.07e-0531222EFO_0006866
DiseaseMammary Carcinoma, Human

PPP1R12B MST1 NCOR1 THBS1 FASN PTPRD PIN1 LSP1 BCAR3 CDH2

6.79e-0552512210C4704874
DiseaseMammary Neoplasms, Human

PPP1R12B MST1 NCOR1 THBS1 FASN PTPRD PIN1 LSP1 BCAR3 CDH2

6.79e-0552512210C1257931
DiseaseMammary Neoplasms

PPP1R12B MST1 NCOR1 THBS1 FASN PTPRD PIN1 LSP1 BCAR3 CDH2

7.00e-0552712210C1458155
DiseaseBreast Carcinoma

PPP1R12B MST1 NCOR1 THBS1 FASN PTPRD PIN1 LSP1 BCAR3 CDH2

8.31e-0553812210C0678222
DiseaseUlcerative Colitis

ECM1 MST1 FCGR2A LSP1

1.37e-04631224C0009324
Diseasecortical surface area measurement

USP34 ZNF536 DNAJC13 NBEAL1 MFHAS1 PPP1R12B LAMC3 MED13L CLSTN1 BCR FRMD4B NCOR1 THBS1 TNRC6A TRIM8 LNX1

1.38e-04134512216EFO_0010736
DiseaseMalignant neoplasm of breast

TICAM1 PPP1R12B FRMPD1 MST1 NCOR1 THBS1 FASN PTPRD PIN1 GOLIM4 LSP1 BCAR3 CDH2 ZNF646

1.46e-04107412214C0006142
Diseasevelopharyngeal dysfunction

MFHAS1 TEKT5 PTPRD LNX1 TTC33

1.57e-041221225EFO_0009336
DiseaseMENTAL RETARDATION, AUTOSOMAL DOMINANT 12

SMARCA2 SMARCA4

1.68e-0451222C3281201
Diseasevital capacity

USP34 ZSCAN31 FRMPD1 LCT TIAM2 NCOR1 THBS1 MELTF PTPRD HMCN1 PIN1 SMARCA2 LNX1 CDH2 UTRN

1.82e-04123612215EFO_0004312
DiseaseChild Development Disorders, Specific

PNKP CHD4 KCNT1

2.33e-04291223C0085997
DiseaseChild Development Deviations

PNKP CHD4 KCNT1

2.33e-04291223C0085996
DiseaseDevelopmental Disabilities

PNKP CHD4 KCNT1

2.58e-04301223C0008073
DiseaseAutoimmune Lymphoproliferative Syndrome

CASP10 TNFAIP3

4.67e-0481222C1328840
Diseasepulmonary function measurement, forced expiratory volume

ZSCAN31 MICB ZKSCAN3

4.84e-04371223EFO_0003892, EFO_0004314
DiseaseIntellectual Disability

TMEM94 CHD3 MED13L FASN NRXN2 TRIM8 QKI CDH2

5.57e-044471228C3714756
Diseaseopportunistic bacterial infectious disease (implicated_via_orthology)

SMARCA2 SMARCA4

5.99e-0491222DOID:0050340 (implicated_via_orthology)
Diseasepulse pressure measurement

USP34 NBEAL1 MFHAS1 CHD2 MED13L QSOX1 MELTF FASN PTPRD SUPT6H TNRC6A TRIM8 LSP1 CORO7 LNX1

6.38e-04139212215EFO_0005763
Diseasealpha fetoprotein measurement

USP34 SETX MANBA NCOR1

8.03e-041001224EFO_0010583
DiseaseMyoclonic Astatic Epilepsy

CHD2 TNRC6A

9.10e-04111222C0393702
Diseaseselective IgA deficiency disease

FAM171A1 FASN TTC33

9.19e-04461223EFO_1001929
Diseasepsoriasis

SPHK2 MANBA REV3L MICB TNFAIP3 TTC33

9.80e-042731226EFO_0000676
Diseasetriacylglycerol 58:12 measurement

NRXN3 LNX1

1.09e-03121222EFO_0010439
DiseaseCharcot-Marie-Tooth Disease

SETX TRPV4

1.09e-03121222C0007959
DiseaseSchizophrenia

ANKK1 GAD1 ZSCAN31 CHD4 TEKT5 THBS1 NRXN3 NRXN2 MICB SMARCA2 QKI

1.11e-0388312211C0036341
Diseasepathological myopia

ZNF536 CHD4 CLSTN2 PTPRD

1.18e-031111224EFO_0004207
DiseaseCoffin-Siris syndrome

SMARCA2 SMARCA4

1.28e-03131222C0265338
DiseaseSjogren's Syndrome

FCGR2A TNFAIP3

1.28e-03131222C1527336
DiseaseSicca Syndrome

FCGR2A TNFAIP3

1.28e-03131222C0086981
DiseaseDrug habituation

TIAM2 QSOX1 NRXN3 BCAR3

1.35e-031151224C0013170
DiseaseDrug abuse

TIAM2 QSOX1 NRXN3 BCAR3

1.35e-031151224C0013146
DiseasePrescription Drug Abuse

TIAM2 QSOX1 NRXN3 BCAR3

1.35e-031151224C4316881
DiseaseSubstance-Related Disorders

TIAM2 QSOX1 NRXN3 BCAR3

1.35e-031151224C0236969
DiseaseDrug Use Disorders

TIAM2 QSOX1 NRXN3 BCAR3

1.35e-031151224C0013222
DiseaseDrug Dependence

TIAM2 QSOX1 NRXN3 BCAR3

1.35e-031151224C1510472
DiseaseSubstance Dependence

TIAM2 QSOX1 NRXN3 BCAR3

1.35e-031151224C0038580
DiseaseSubstance Use Disorders

TIAM2 QSOX1 NRXN3 BCAR3

1.35e-031151224C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

TIAM2 QSOX1 NRXN3 BCAR3

1.35e-031151224C0029231
DiseaseSubstance abuse problem

TIAM2 QSOX1 NRXN3 BCAR3

1.39e-031161224C0740858
Diseaseunipolar depression, anxiety

ZSCAN31 PTPRD

1.49e-03141222EFO_0003761, EFO_0005230
Diseaset-tau measurement

NRXN3 PLXNA4 GOLIM4 SNX9

1.89e-031261224EFO_0004760
DiseaseSchizoaffective disorder-bipolar type

NRXN3 SCN3B

1.96e-03161222EFO_0009965
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

PNKP TRIM8

1.96e-03161222C0393706
Diseaseproliferative diabetic retinopathy

NRXN3 GOLIM4 UTRN

2.08e-03611223EFO_0009322
Diseasenon-Hodgkin lymphoma (is_implicated_in)

CASP10 FCGR2A

2.21e-03171222DOID:0060060 (is_implicated_in)
Diseaserheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement

RGS22 FCGR2A TNFAIP3

2.29e-03631223EFO_0000685, EFO_0007791, EFO_0009459
DiseaseGlobal developmental delay

TMEM94 CHD3 TRIM8 CDH2

2.30e-031331224C0557874
Diseaseage-related hearing impairment

ZNF536 CLSTN2 MED13L ZFP69 HEG1 PLXNA4

2.33e-033241226EFO_0005782
Diseaserheumatoid arthritis, COVID-19

ZSCAN31 MICB ZKSCAN3

2.39e-03641223EFO_0000685, MONDO_0100096
Diseasesclerosing cholangitis

MANBA MST1 TNFAIP3

2.61e-03661223EFO_0004268
DiseaseCocaine Dependence

ANKK1 GAD1 DBH SMARCA4

2.70e-031391224C0600427
Diseasealkaline phosphatase measurement

USP34 DNAJC13 CACUL1 MANBA MFHAS1 CHD3 DBH ITPKB TRIM8 SNX9 UTRN

3.30e-03101512211EFO_0004533
DiseaseLymphoma, Diffuse

FPGS CASP10

3.38e-03211222C3714542
DiseaseLow Grade Lymphoma (neoplasm)

FPGS CASP10

3.38e-03211222C0079747
DiseaseLymphoma, Intermediate-Grade

FPGS CASP10

3.38e-03211222C0079741
DiseaseHigh Grade Lymphoma (neoplasm)

FPGS CASP10

3.38e-03211222C0079740
DiseaseDiffuse Mixed-Cell Lymphoma

FPGS CASP10

3.38e-03211222C0079757
Diseasesystemising measurement

TSHZ3 CLSTN1

3.38e-03211222EFO_0010221
DiseaseLymphoma, Undifferentiated

FPGS CASP10

3.38e-03211222C0024306
DiseaseReticulosarcoma

FPGS CASP10

3.38e-03211222C0024302
DiseaseLymphoma, Mixed-Cell

FPGS CASP10

3.38e-03211222C0024304
Diseasemyocardial infarction

ANKRD31 NBEAL1 DCBLD1 ZNF77 SMARCA4 QKI

3.41e-033501226EFO_0000612
DiseaseLymphoma, Non-Hodgkin, Familial

FPGS CASP10

3.71e-03221222C4721532
DiseaseLymphoma, Small Noncleaved-Cell

FPGS CASP10

3.71e-03221222C0079770
Diseasepulse pressure measurement, alcohol consumption measurement

LSP1 LNX1

3.71e-03221222EFO_0005763, EFO_0007878
Diseasemelanoma

INCENP DCBLD1 CASP10 MELTF FASN

3.76e-032481225C0025202
Diseaseglucagon measurement

ZNF536 FRMD4B TIAM2 MELTF

3.89e-031541224EFO_0008463
DiseaseParkinson's disease (is_implicated_in)

DNAJC13 POLG DBH

3.89e-03761223DOID:14330 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
QRNHSLDNWPNTTRV

ERVPABLB-1

216

P60509
QQRDLFATDWSQQPG

ERVPABLB-1

246

P60509
TGSQQQAWPGRQSQE

TFAP2C

96

Q92754
TQDGIQESPWQDRHG

BCAR3

86

O75815
PRVQQWSHQQRVGDL

BCR

566

P11274
GWTPLHLAAQNNFEN

ANKK1

461

Q8NFD2
RSPESDSIQWFHNGN

FCGR2A

66

P12318
QWLDTPLHAAARQSN

ASB11

226

Q8WXH4
GDPQNATRQQQLEWD

CLSTN1

961

O94985
QDLWTVNGLPNENNS

ANGEL2

516

Q5VTE6
QAHWQGLAQPEAQIT

DHTKD1

506

Q96HY7
HGQNGARQAQLEWDD

CLSTN2

936

Q9H4D0
SSPPWDHGNQRQEAA

CCDC140

16

Q96MF4
HLAQQQEPWSRLNST

CFAP276

36

Q5T5A4
NHNNWEAAVDGFRQP

CACUL1

21

Q86Y37
GTSSRNPGQQRNHFW

MKRN4P

441

Q13434
PDAAHQISQQVGWQD

NBEAL1

1251

Q6ZS30
WHRENNEQPTLQSSA

RBM27

671

Q9P2N5
KENTWRQHLNGQISP

RBM46

311

Q8TBY0
EQNRGKPNWEHLNED

QKI

136

Q96PU8
NEQEQPLGQWHLSKR

QSOX1

631

O00391
HQSQNLQQPRGSQAW

RFWD3

406

Q6PCD5
VNLNDNAGWTPLHEA

ANKRD31

1181

Q8N7Z5
SQNQHQPPENWAEAL

PNMA8A

136

Q86V59
KAETPNNWNATEDQH

PNMA8A

211

Q86V59
DEPQTWPTDHRAQQG

MISP

46

Q8IVT2
WPTDHRAQQGVQRQG

MISP

51

Q8IVT2
QHLQDAGTREWSPQN

FAM171A1

646

Q5VUB5
QPWSGEENDNHSRLK

MED13L

1486

Q71F56
HTWDQGANNRQQPIE

JHY

106

Q6NUN7
EVPENNGNNSWPHND

INCENP

391

Q9NQS7
NGNNSWPHNDTEIAN

INCENP

396

Q9NQS7
NEVPHAEAWINGTNL

MFHAS1

856

Q9Y4C4
RLNPTWNHPDQDTEA

MYG1

201

Q9HB07
SVVIGRHQNPWQECN

LIPT1

71

Q9Y234
HTSRGQEGQESPEQW

KCNT1

516

Q5JUK3
PQTHNARDQWLQDAF

FAM89B

171

Q8N5H3
SKQQPLGWSNHQAEL

CCDC9B

456

Q6ZUT6
HQDQIFSLAWSPDGQ

CORO7

636

P57737
NGIERANSVTWNPHK

GAD1

391

Q99259
NHITNASQWERPSGN

PIN1

26

Q13526
QHCPAQESQWLELSG

PLXNA4

836

Q9HCM2
NHITNPSQWERPSGN

PIN1P1

26

O15428
PNWVSPSDHQRAQIN

FAM205BP

226

Q63HN1
NSDKPVNDNQWHNVV

NRXN2

991

Q9P2S2
IKGNSDRPLNDNQWH

NRXN3

941

Q9Y4C0
PTQRDWQEQLVVGHN

POLG

256

P54098
QRSPDIFQEAGWNSN

LNX1

466

Q8TBB1
PQALQDHGGWQNESV

LCT

501

P09848
QRTWQALAHEYNSQP

MSANTD3

46

Q96H12
LSHNTQQWGDVLPDG

MICB

246

Q29980
RWQNDSPTFGEHQLA

HEG1

411

Q9ULI3
PAWQNSIRHNLSLND

FOXD4

146

Q12950
WQKEGINVNTSGRNH

HMCN1

4021

Q96RW7
NDVWQNHEAVPGRAE

GOLIM4

286

O00461
FNVHWDRNDTNLIPN

HERC5

836

Q9UII4
DDTGQQNWLQLDHRV

FRMD4B

106

Q9Y2L6
ARAAQAPHWKSLQQQ

HDAC10

346

Q969S8
DSDWNPQNDLQAQAR

CHD2

886

O14647
SDWNPHNDIQAFSRA

CHD3

1156

Q12873
ADVHASLQWNFRPQQ

COX11

156

Q9Y6N1
LWPGNKQQAHRVSAE

FRMPD1

501

Q5SYB0
WSDQKGQIHLDPQQD

DBH

116

P09172
EPQGLDAASWAQIHQ

CCDC78

376

A2IDD5
LHQQQQQQEPWGEAA

ATG9B

841

Q674R7
GTHENPELIWNDNSR

DNAJC13

1921

O75165
HPSIIIWSGNNENEE

MANBA

446

O00462
HDNQANVRSLVTWGN

IFIT1

86

P09914
FGDWSQRPEQRQQHE

LSP1

81

P33241
WNGENHNGIENIDLS

CDC20B

256

Q86Y33
QQHWNHLDEEQASPD

FPGS

471

Q05932
ALPQESWQNKHAGSN

CASP10

226

Q92851
EPESWNAAQHCQQDR

ECM1

141

Q16610
PSRNSWDHRIQAQGQ

ENAM

761

Q9NRM1
NSPWTVSLRNRQGQH

MST1

491

P26927
DQVHWSPGQARLQDQ

DCBLD1

281

Q8N8Z6
ELQQHDVAQGQWDPA

FASN

1286

P49327
SDWNPHNDIQAFSRA

CHD4

1146

Q14839
DWHPENQNLSQVSDP

RSC1A1

151

Q92681
QHAALGGTATRQNNW

SCAMP3

121

O14828
NDNRPEFLHQVWNGT

CDH2

261

P19022
DQHEQKFTGLPRQWQ

PAK4

26

O96013
PGQQFTWEHSNLEVN

PTPRD

1366

P23468
PDQNNIWIRDHEDSG

MEIS3P1

96

A6NDR6
QWDGTQHGVELRQQQ

UTRN

2316

P46939
RNTNTPNNWDTAFGH

SNX9

136

Q9Y5X1
SDWNPHQDLQAQDRA

SMARCA2

1146

P51531
NTNGHNSEPWAAELR

MELTF

581

P08582
DGSQWNEEHLRNIQS

RGS22

481

Q8NE09
EGQTLQHDVPWQEGN

ITPKB

906

P27987
SAVNQAAPHQQNRIW

NCOR1

2406

O75376
SDWNPHQDLQAQDRA

SMARCA4

1176

P51532
QLSAAELQSRNQGHW

SELENOO

541

Q9BVL4
SVWQDHPDDNNSVQD

SETX

1091

Q7Z333
PHDWDQSNQLQVRGA

TEKT5

91

Q96M29
WDHLQEQANDGTPIS

PNKP

266

Q96T60
GFTQEEWQHLDPAQR

ZNF37A

16

P17032
QQQPKSNSHAAIDWG

SUPT6H

1661

Q7KZ85
SGQSSRNDWQVLQPE

SIRPB2

31

Q5JXA9
SQNDPNWVVRHQGKE

THBS1

971

P07996
NWRFDNTGDQHQIPQ

ZNF77

86

Q15935
WDQETHLRGNNFSGQ

ZSCAN31

21

Q96LW9
QSSHQRPGEQSEAWL

ZSCAN32

166

Q9NX65
NPAGTENNSIWELIH

TIAM2

1406

Q8IVF5
RHNWSGLDKQSDIQN

MIOS

471

Q9NXC5
WQENSEQGRREGHAQ

TNFAIP3

356

P21580
PQPNNSDWIQGHTRK

REV3L

1791

O60673
QDQRPDQELTGSWGH

SPHK2

11

Q9NRA0
NTLHLSNEQERGDWP

TMEM94

476

Q12767
LNNHMWNQRGSQAPE

TICAM1

691

Q8IUC6
WDNRDNSSQLQPGSH

ZNF646

1516

O15015
HQEVESPFQGRLQWN

SCN3B

81

Q9NY72
ETPEGTFWANNHGRN

PPP1R3F

266

Q6ZSY5
AFWVTNPNNTIRHNA

PKHD1L1

2561

Q86WI1
NNRWFNGQPIHAELS

U2AF1

131

Q01081
DDNHETDNNNPKRWS

TSHZ3

241

Q63HK5
SQAPEKQWHSQGLLQ

ZNF536

1226

O15090
NLQSWVREQHPESGE

ZKSCAN3

101

Q9BRR0
QSFQHQQDPSQIDWA

PNISR

21

Q8TF01
EPNNWLEGQQDSHLS

ZFP2

16

Q6ZN57
PAFTRQLASHQNIQW

USP34

2866

Q70CQ2
SQQNGHQVWEPEEDS

RPTN

641

Q6XPR3
VRDWLDASQQPGHQD

TRIM8

521

Q9BZR9
SHWNQNLGIINEDPG

TRPV4

786

Q9HBA0
EWNKLPSNQHSNDSA

TNRC6A

616

Q8NDV7
TQEEWGQLAPAHQNL

ZFP69

86

Q49AA0
QQNPHSWESWQTLGR

TTC33

121

Q6PID6
THQGQSPRNSWDRGT

ZNF641

421

Q96N77
WNSDTQNPYHQQALA

GEMIN4

276

P57678
DTHQAPAQALNETQW

LAMC3

1496

Q9Y6N6
NVNQQDNEGWTPLHA

PPP1R12B

116

O60237