Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	methenyltetrahydrofolate cyclohydrolase activity	MTHFD1 MTHFD2 MTHFD2L	4.13e-08	3	70	3	GO:0004477
GeneOntologyMolecularFunction	methylenetetrahydrofolate dehydrogenase (NAD+) activity	MTHFD1 MTHFD2 MTHFD2L	4.13e-08	3	70	3	GO:0004487
GeneOntologyMolecularFunction	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	MTHFD1 MTHFD2 MTHFD2L	1.65e-07	4	70	3	GO:0004486
GeneOntologyMolecularFunction	methylenetetrahydrofolate dehydrogenase (NADP+) activity	MTHFD1 MTHFD2 MTHFD2L	1.65e-07	4	70	3	GO:0004488
GeneOntologyMolecularFunction	cyclohydrolase activity	MTHFD1 MTHFD2 MTHFD2L	4.11e-07	5	70	3	GO:0019238
GeneOntologyMolecularFunction	NADPH-hemoprotein reductase activity	NDOR1 POR MTRR	4.11e-07	5	70	3	GO:0003958
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	NDOR1 POR MTRR	8.87e-06	12	70	3	GO:0016653
GeneOntologyMolecularFunction	FMN binding	NDOR1 POR MTRR	2.24e-05	16	70	3	GO:0010181
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	MTHFD1 MTHFD2 MTHFD2L	3.24e-05	18	70	3	GO:0016646
GeneOntologyMolecularFunction	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	DSG2 DSP	1.20e-04	5	70	2	GO:0086083
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH group of donors	MTHFD1 MTHFD2 MTHFD2L	1.57e-04	30	70	3	GO:0016645
GeneOntologyMolecularFunction	acetyl-CoA C-acetyltransferase activity	ACAT2 ACAA2	1.80e-04	6	70	2	GO:0003985
GeneOntologyMolecularFunction	C-acetyltransferase activity	ACAT2 ACAA2	2.52e-04	7	70	2	GO:0016453
GeneOntologyMolecularFunction	acetyl-CoA C-acyltransferase activity	ACAT2 ACAA2	2.52e-04	7	70	2	GO:0003988
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	MTHFD1 MTHFD2 MTHFD2L	2.71e-04	36	70	3	GO:0016814
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H	NDOR1 POR MTRR NDUFB6	3.47e-04	95	70	4	GO:0016651
GeneOntologyMolecularFunction	chondroitin sulfate binding	PTPRS ADGRE2	6.53e-04	11	70	2	GO:0035374
GeneOntologyMolecularFunction	NADP binding	NDOR1 POR MTRR	1.35e-03	62	70	3	GO:0050661
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	MTHFD1 MTHFD2 MTHFD2L SIRT3	1.73e-03	146	70	4	GO:0016810
GeneOntologyMolecularFunction	protein binding involved in heterotypic cell-cell adhesion	DSG2 DSP	1.79e-03	18	70	2	GO:0086080
GeneOntologyMolecularFunction	C-acyltransferase activity	ACAT2 ACAA2	2.44e-03	21	70	2	GO:0016408
GeneOntologyMolecularFunction	mRNA binding	NYNRIN RBM15B CSTF3 SRBD1 RBM20 SF1 CSTF2T AQR	2.89e-03	694	70	8	GO:0003729
GeneOntologyMolecularFunction	NADPH binding	NDOR1 MTRR	3.73e-03	26	70	2	GO:0070402
GeneOntologyBiologicalProcess	folic acid-containing compound metabolic process	MTHFD1 MTHFD2 MTHFD2L MTRR	5.53e-06	34	71	4	GO:0006760
GeneOntologyBiologicalProcess	methionine biosynthetic process	MTHFD1 MTHFD2L MTRR	8.41e-06	12	71	3	GO:0009086
GeneOntologyBiologicalProcess	pteridine-containing compound metabolic process	MTHFD1 MTHFD2 MTHFD2L MTRR	1.07e-05	40	71	4	GO:0042558
GeneOntologyBiologicalProcess	L-histidine biosynthetic process	MTHFD1 MTHFD2L	1.17e-05	2	71	2	GO:0000105
GeneOntologyBiologicalProcess	tetrahydrofolate interconversion	MTHFD1 MTHFD2 MTHFD2L	2.12e-05	16	71	3	GO:0035999
GeneOntologyBiologicalProcess	methionine metabolic process	MTHFD1 MTHFD2L MTRR	2.12e-05	16	71	3	GO:0006555
GeneOntologyBiologicalProcess	folic acid metabolic process	MTHFD2 MTHFD2L MTRR	3.07e-05	18	71	3	GO:0046655
GeneOntologyBiologicalProcess	sulfur amino acid biosynthetic process	MTHFD1 MTHFD2L MTRR	4.97e-05	21	71	3	GO:0000097
GeneOntologyBiologicalProcess	aspartate family amino acid biosynthetic process	MTHFD1 MTHFD2L MTRR	5.74e-05	22	71	3	GO:0009067
GeneOntologyBiologicalProcess	tetrahydrofolate metabolic process	MTHFD1 MTHFD2 MTHFD2L	6.59e-05	23	71	3	GO:0046653
GeneOntologyBiologicalProcess	10-formyltetrahydrofolate metabolic process	MTHFD1 MTHFD2L	1.74e-04	6	71	2	GO:0009256
GeneOntologyBiologicalProcess	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	DSG2 DSP	1.74e-04	6	71	2	GO:0086073
GeneOntologyBiologicalProcess	aromatic amino acid family biosynthetic process	MTHFD1 MTHFD2L	1.74e-04	6	71	2	GO:0009073
GeneOntologyBiologicalProcess	negative regulation of interferon-alpha production	PTPRS NLRC3	2.43e-04	7	71	2	GO:0032687
GeneOntologyBiologicalProcess	cardiac muscle cell-cardiac muscle cell adhesion	DSG2 DSP	2.43e-04	7	71	2	GO:0086042
GeneOntologyBiologicalProcess	sulfur amino acid metabolic process	MTHFD1 MTHFD2L MTRR	3.52e-04	40	71	3	GO:0000096
GeneOntologyBiologicalProcess	purine nucleotide biosynthetic process	GMPS HNF1A MTHFD1 MTHFD2L DLAT NDUFB6	4.06e-04	280	71	6	GO:0006164
GeneOntologyBiologicalProcess	one-carbon metabolic process	MTHFD1 MTHFD2 MTHFD2L	4.68e-04	44	71	3	GO:0006730
GeneOntologyBiologicalProcess	purine-containing compound biosynthetic process	GMPS HNF1A MTHFD1 MTHFD2L DLAT NDUFB6	4.71e-04	288	71	6	GO:0072522
GeneOntologyBiologicalProcess	L-histidine metabolic process	MTHFD1 MTHFD2L	5.16e-04	10	71	2	GO:0006547
GeneOntologyBiologicalProcess	desmosome organization	DSG2 DSP	5.16e-04	10	71	2	GO:0002934
GeneOntologyBiologicalProcess	negative regulation of fibroblast proliferation	DACH1 KMT2A NLRC3	5.34e-04	46	71	3	GO:0048147
Domain	THF_DHG_CYH_1	MTHFD1 MTHFD2 MTHFD2L	5.04e-08	3	70	3	PS00766
Domain	THF_DHG_CYH_2	MTHFD1 MTHFD2 MTHFD2L	5.04e-08	3	70	3	PS00767
Domain	THF_DH/CycHdrlase_CS	MTHFD1 MTHFD2 MTHFD2L	5.04e-08	3	70	3	IPR020867
Domain	THF_DHG_CYH	MTHFD1 MTHFD2 MTHFD2L	2.01e-07	4	70	3	PF00763
Domain	THF_DH/CycHdrlase	MTHFD1 MTHFD2 MTHFD2L	2.01e-07	4	70	3	IPR000672
Domain	THF_DHG_CYH_C	MTHFD1 MTHFD2 MTHFD2L	2.01e-07	4	70	3	PF02882
Domain	THF_DH/CycHdrlase_cat_dom	MTHFD1 MTHFD2 MTHFD2L	2.01e-07	4	70	3	IPR020630
Domain	THF_DH/CycHdrlase_NAD-bd_dom	MTHFD1 MTHFD2 MTHFD2L	2.01e-07	4	70	3	IPR020631
Domain	FAD_binding_1	NDOR1 POR MTRR	1.00e-06	6	70	3	PF00667
Domain	FAD-binding_1	NDOR1 POR MTRR	1.00e-06	6	70	3	IPR003097
Domain	-	NDOR1 POR MTRR	1.00e-06	6	70	3	1.20.990.10
Domain	NADPH_Cyt_P450_Rdtase_dom3	NDOR1 POR MTRR	1.00e-06	6	70	3	IPR023173
Domain	FLAVODOXIN_LIKE	NDOR1 POR MTRR	2.79e-06	8	70	3	PS50902
Domain	Flavodoxin/NO_synth	NDOR1 POR MTRR	2.79e-06	8	70	3	IPR008254
Domain	Flavdoxin-like	NDOR1 POR MTRR	2.79e-06	8	70	3	IPR001094
Domain	Flavodoxin_1	NDOR1 POR MTRR	2.79e-06	8	70	3	PF00258
Domain	Flavoprotein-like_dom	NDOR1 POR MTRR	5.94e-06	10	70	3	IPR029039
Domain	Flavoprot_Pyr_Nucl_cyt_Rdtase	NDOR1 POR MTRR	5.94e-06	10	70	3	IPR001709
Domain	-	NDOR1 POR MTRR	5.94e-06	10	70	3	3.40.50.360
Domain	OxRdtase_FAD/NAD-bd	NDOR1 POR MTRR	1.08e-05	12	70	3	IPR001433
Domain	NAD_binding_1	NDOR1 POR MTRR	1.08e-05	12	70	3	PF00175
Domain	Fd_Rdtase_FAD-bd	NDOR1 POR MTRR	4.68e-05	19	70	3	IPR017927
Domain	FAD_FR	NDOR1 POR MTRR	4.68e-05	19	70	3	PS51384
Domain	Riboflavin_synthase-like_b-brl	NDOR1 POR MTRR	4.68e-05	19	70	3	IPR017938
Domain	Thiolase_AS	ACAT2 ACAA2	1.37e-04	5	70	2	IPR020610
Domain	Thiolase_C	ACAT2 ACAA2	2.06e-04	6	70	2	PF02803
Domain	Thiolase_N	ACAT2 ACAA2	2.06e-04	6	70	2	PF00108
Domain	THIOLASE_2	ACAT2 ACAA2	2.06e-04	6	70	2	PS00737
Domain	THIOLASE_1	ACAT2 ACAA2	2.06e-04	6	70	2	PS00098
Domain	THIOLASE_3	ACAT2 ACAA2	2.06e-04	6	70	2	PS00099
Domain	Thiolase_N	ACAT2 ACAA2	2.06e-04	6	70	2	IPR020616
Domain	Thiolase_C	ACAT2 ACAA2	2.06e-04	6	70	2	IPR020617
Domain	Thiolase_CS	ACAT2 ACAA2	2.06e-04	6	70	2	IPR020613
Domain	Thiolase	ACAT2 ACAA2	2.06e-04	6	70	2	IPR002155
Domain	-	ACAT2 ACAA2	6.11e-04	10	70	2	3.40.47.10
Domain	Thiolase-like	ACAT2 ACAA2	6.11e-04	10	70	2	IPR016039
Domain	Fib_collagen_C	COL5A2 COL24A1	7.45e-04	11	70	2	IPR000885
Domain	COLFI	COL5A2 COL24A1	7.45e-04	11	70	2	PF01410
Domain	NC1_FIB	COL5A2 COL24A1	7.45e-04	11	70	2	PS51461
Domain	Fib_collagen_C	COL5A2 COL24A1	7.45e-04	11	70	2	PD002078
Domain	COLFI	COL5A2 COL24A1	7.45e-04	11	70	2	SM00038
Domain	Collagen	COL5A2 COL24A1 EDA	4.00e-03	85	70	3	IPR008160
Domain	Collagen	COL5A2 COL24A1 EDA	4.00e-03	85	70	3	PF01391
Domain	-	HNF1A POU3F2	4.57e-03	27	70	2	1.10.260.40
Domain	AT_hook	KMT2A ZNF653	4.57e-03	27	70	2	SM00384
Domain	AT_hook_DNA-bd_motif	KMT2A ZNF653	4.57e-03	27	70	2	IPR017956
Domain	Lambda_DNA-bd_dom	HNF1A POU3F2	5.27e-03	29	70	2	IPR010982
Pathway	KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	MTHFD1 MTHFD2 MTHFD2L	3.21e-05	16	56	3	M5244
Pathway	KEGG_ONE_CARBON_POOL_BY_FOLATE	MTHFD1 MTHFD2 MTHFD2L	3.88e-05	17	56	3	M12039
Pathway	REACTOME_METABOLISM_OF_FOLATE_AND_PTERINES	MTHFD1 MTHFD2 MTHFD2L	3.88e-05	17	56	3	M27085
Pathway	WP_DISORDERS_OF_FOLATE_METABOLISM_AND_TRANSPORT	MTHFD1 MTHFD2 MTHFD2L	5.50e-05	19	56	3	M39777
Pathway	REACTOME_METABOLISM_OF_FOLATE_AND_PTERINES	MTHFD1 MTHFD2 MTHFD2L	7.51e-05	21	56	3	MM14763
Pathway	WP_FOLATE_METABOLISM	ABCA1 MTHFD1 MTHFD2 MTRR	1.59e-04	69	56	4	M39617
Pathway	WP_ONECARBON_METABOLISM	MTHFD1 MTHFD2 MTRR	2.02e-04	29	56	3	M39471
Pathway	WP_ONECARBON_METABOLISM	MTHFD1 MTHFD2 MTRR	3.26e-04	34	56	3	MM15859
Pubmed	Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues.	MTHFD1 MTHFD2 MTHFD2L	3.26e-08	4	71	3	24733394
Pubmed	Liver and brain differential expression of one-carbon metabolism genes during ontogenesis.	MTHFD1 MTHFD2 MTHFD2L MTRR	6.24e-07	33	71	4	34702858
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	GMPS ZSWIM8 DSP UGGT1 KMT2A DLAT GIGYF2 FRYL HSPA2 AQR	8.38e-07	653	71	10	22586326
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	MON2 ZSWIM8 TDRKH PNPLA6 UGGT1 CHID1 HSPA2	1.83e-06	282	71	7	35007762
Pubmed	118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.	MTHFD1 MTHFD2 MTRR	2.92e-06	14	71	3	19493349
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	GMPS FBXO22 PNPLA6 GATAD2A ACAT2 DSP MTHFD1 DLAT AKAP13 ACAA2 SRBD1 SNRPA AQR	3.14e-06	1353	71	13	29467282
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	HOXA13 GATAD2A DSP DACH1 RBM15B CSTF3 KMT2A GIGYF2 SNRPA HSPA2 SF1	3.56e-06	954	71	11	36373674
Pubmed	The expression of mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase supports a role in rapid cell growth.	MTHFD1 MTHFD2	4.11e-06	2	71	2	15342116
Pubmed	Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia.	KMT2A FRYL	4.11e-06	2	71	2	17854671
Pubmed	Proximal FAD histidine residue influences interflavin electron transfer in cytochrome P450 reductase and methionine synthase reductase.	POR MTRR	4.11e-06	2	71	2	24589657
Pubmed	Nucleotide sequence of the human NAD-dependent methylene tetrahydrofolate dehydrogenase-cyclohydrolase.	MTHFD1 MTHFD2	4.11e-06	2	71	2	2587219
Pubmed	[Association of maternal MTHFD1 and MTHFD2 gene polymorphisms with congenital heart disease in offspring].	MTHFD1 MTHFD2	4.11e-06	2	71	2	35894196
Pubmed	Population-prevalent desmosomal mutations predisposing to arrhythmogenic right ventricular cardiomyopathy.	DSG2 DSP	4.11e-06	2	71	2	21397041
Pubmed	Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy.	SDK2 SDK1	4.11e-06	2	71	2	15213259
Pubmed	Deficits in Col5a2 Expression Result in Novel Skin and Adipose Abnormalities and Predisposition to Aortic Aneurysms and Dissections.	COL5A2 NDOR1	4.11e-06	2	71	2	28734943
Pubmed	Definition of the critical domains required for homophilic targeting of mouse sidekick molecules.	SDK2 SDK1	4.11e-06	2	71	2	15703275
Pubmed	Architecture of cell-cell adhesion mediated by sidekicks.	SDK2 SDK1	4.11e-06	2	71	2	30150416
Pubmed	Genetic polymorphisms involved in folate metabolism and maternal risk for down syndrome: a meta-analysis.	MTHFD1 MTRR	4.11e-06	2	71	2	25544792
Pubmed	AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner.	KMT2A FRYL	4.11e-06	2	71	2	16061630
Pubmed	Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina.	SDK2 SDK1	4.11e-06	2	71	2	12230981
Pubmed	Mammalian mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase derived from a trifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase.	MTHFD1 MTHFD2	4.11e-06	2	71	2	12061812
Pubmed	t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (GUANOSINE 5' MONOPHOSPHATE SYNTHETASE) gene.	GMPS KMT2A	4.11e-06	2	71	2	11110714
Pubmed	Molecular basis of sidekick-mediated cell-cell adhesion and specificity.	SDK2 SDK1	4.11e-06	2	71	2	27644106
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	GMPS SMAP1 FBXO22 GATAD2A DSP MTHFD1 UGGT1 DLAT GIGYF2 AKAP13 SNRPA SF1 AQR	5.10e-06	1415	71	13	28515276
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	COL5A2 VPS13D FBXO22 ANK3 MTHFD1 DUSP9 KMT2A GIGYF2	7.95e-06	497	71	8	36774506
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	PNPLA6 GATAD2A DSG2 DSP MTHFD1 UGGT1 RBM15B SRBD1 SNRPA SF1 AQR PHC2	8.42e-06	1257	71	12	36526897
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MON2 GMPS ANK3 DSP PTPRS UGGT1 DUSP9 CSTF3 POR HSPA2 RBM20	8.73e-06	1049	71	11	27880917
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	SMAP1 HNF1A ACAT2 DSP MTHFD1 PTPRS MTHFD2 UGGT1 CSTF3 AKAP13 FRYL SNRPA	1.04e-05	1284	71	12	17353931
Pubmed	Association of methionine synthase (rs1805087), methionine synthase reductase (rs1801394), and methylenetetrahydrofolate dehydrogenase 1 (rs2236225) genetic polymorphisms with recurrent implantation failure.	MTHFD1 MTRR	1.23e-05	3	71	2	31099277
Pubmed	NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.	NDOR1 KMT2A	1.23e-05	3	71	2	27889185
Pubmed	Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China.	MTHFD1 MTRR	1.23e-05	3	71	2	29392422
Pubmed	Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos.	MTHFD1 MTHFD2	1.23e-05	3	71	2	19948730
Pubmed	Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome.	KMT2A FRYL	1.23e-05	3	71	2	18195096
Pubmed	MTHFD 1958G>A and MTR 2756A>G polymorphisms are associated with bipolar disorder and schizophrenia.	MTHFD1 MTRR	1.23e-05	3	71	2	17417062
Pubmed	Arrhythmogenic right ventricular dysplasia.	DSG2 DSP	1.23e-05	3	71	2	18596851
Pubmed	One-carbon metabolism enzyme polymorphisms and uteroplacental insufficiency.	MTHFD1 MTRR	1.23e-05	3	71	2	18771981
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	GMPS HOXA13 GATAD2A MTHFD1 DACH1 CSTF3 KMT2A C15orf39 SNRPA SF1 CSTF2T	1.39e-05	1103	71	11	34189442
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	DSP MTHFD1 DLAT GIGYF2 FRYL SRBD1 SNRPA AQR	1.67e-05	551	71	8	34728620
Pubmed	Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.	HNF1A ABCA1 ACAA2 IRS1	1.74e-05	75	71	4	20571754
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	MON2 GMPS CACNA1B SMAP1 ANK3 DSP MTHFD1 POR DLAT AQP4 HSPA2	1.88e-05	1139	71	11	36417873
Pubmed	Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.	ACAT2 DLAT	2.46e-05	4	71	2	25042803
Pubmed	IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?	HNF1A IRS1	2.46e-05	4	71	2	16367885
Pubmed	Arrhythmogenic right ventricular dysplasia: clinical characteristics and identification of novel desmosome gene mutations.	DSG2 DSP	2.46e-05	4	71	2	18632414
Pubmed	Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate.	MTHFD1 MTRR	2.46e-05	4	71	2	20386493
Pubmed	Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure.	DSG2 DSP	2.46e-05	4	71	2	16303847
Pubmed	Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.	DSG2 DSP	2.46e-05	4	71	2	8858175
Pubmed	Arrhythmogenic right ventricular dysplasia/cardiomyopathy diagnostic task force criteria: impact of new task force criteria.	DSG2 DSP	2.46e-05	4	71	2	20215590
Pubmed	Mutated desmoglein-2 proteins are incorporated into desmosomes and exhibit dominant-negative effects in arrhythmogenic right ventricular cardiomyopathy.	DSG2 DSP	2.46e-05	4	71	2	23381804
Pubmed	Lower than expected desmosomal gene mutation prevalence in endurance athletes with complex ventricular arrhythmias of right ventricular origin.	DSG2 DSP	2.46e-05	4	71	2	20525856
Pubmed	Plasma folate, related genetic variants, and colorectal cancer risk in EPIC.	MTHFD1 MTRR	2.46e-05	4	71	2	20447924
Pubmed	[Features of allele polymorphism of genes involved in homocysteine and folate metabolism in patients with atherosclerosis of the lower extremity arteries].	MTHFD1 MTRR	2.46e-05	4	71	2	20209990
Pubmed	Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.	GMPS GATAD2A CHID1 HSPA2 SF1 CSTF2T	2.53e-05	283	71	6	28533407
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TUBGCP6 PNPLA6 DSP RBM15B KMT2A GIGYF2 SF1 CSTF2T PHC2	2.78e-05	774	71	9	15302935
Pubmed	Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.	MTHFD1 MTHFD2 MTRR	2.87e-05	29	71	3	19048631
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DSG2 DSP MTHFD1 UGGT1 RBM15B CSTF3 POR DLAT GIGYF2 SNRPA SF1 AQR	2.92e-05	1425	71	12	30948266
Pubmed	Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.	DSG2 DSP	4.09e-05	5	71	2	22781308
Pubmed	Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1.	NDOR1 KMT2A	4.09e-05	5	71	2	32241942
Pubmed	Genotype frequencies and linkage disequilibrium in the CEPH human diversity panel for variants in folate pathway genes MTHFR, MTHFD, MTRR, RFC1, and GCP2.	MTHFD1 MTRR	4.09e-05	5	71	2	14632302
Pubmed	Wide spectrum of desmosomal mutations in Danish patients with arrhythmogenic right ventricular cardiomyopathy.	DSG2 DSP	4.09e-05	5	71	2	20864495
Pubmed	Folate and choline metabolism gene variants and development of uterine cervical carcinoma.	MTHFD1 MTRR	4.09e-05	5	71	2	21349258
Pubmed	Comprehensive desmosome mutation analysis in north americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy.	DSG2 DSP	4.09e-05	5	71	2	20031617
Pubmed	The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges.	SDK2 SDK1	4.09e-05	5	71	2	34545809
Pubmed	Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia.	DSG2 DSP	4.09e-05	5	71	2	19863551
Pubmed	Prognostic significance of folate metabolism polymorphisms for lung cancer.	MTHFD1 MTRR	4.09e-05	5	71	2	17533396
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	GATAD2A DSG2 DSP MTHFD1 UGGT1 CSTF3 GIGYF2 SNRPA SF1 AQR	4.25e-05	1024	71	10	24711643
Pubmed	Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.	HNF1A DUSP9 IRS1	4.66e-05	34	71	3	20581827
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	TUBGCP6 ZSWIM8 PNPLA6 DSP UGGT1 KMT2A GIGYF2 HSPA2	4.78e-05	639	71	8	23443559
Pubmed	Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.	MTHFD1 MTRR IRS1	5.09e-05	35	71	3	18992148
Pubmed	Agrin has a pathological role in the progression of oral cancer.	VPS13D PNPLA6 ANK3 MTHFD1 PHC2	5.33e-05	197	71	5	29872149
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	GMPS GATAD2A DSG2 DSP MTHFD1 DLAT HSPA2	5.45e-05	477	71	7	31300519
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	PNPLA6 GATAD2A DSG2 RBM15B CSTF3 KMT2A GIGYF2 SF1 AQR	5.58e-05	847	71	9	35850772
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	UGGT1 KMT2A GIGYF2 HSPA2 AQR	6.00e-05	202	71	5	24639526
Pubmed	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	HNF1A ABCA1 DSP MTHFD1 MTHFD2 MTRR	6.05e-05	331	71	6	20634891
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	GMPS FBXO22 DSG2 DSP MTHFD1 UGGT1 AKAP13 CHID1 SNRPA NDUFB6 AQR	6.11e-05	1297	71	11	33545068
Pubmed	Expression and Roles of the Immunoglobulin Superfamily Recognition Molecule Sidekick1 in Mouse Retina.	SDK2 SDK1	6.13e-05	6	71	2	30687002
Pubmed	Reporter-nanobody fusions (RANbodies) as versatile, small, sensitive immunohistochemical reagents.	SDK2 SDK1	6.13e-05	6	71	2	29440485
Pubmed	Polymorphisms in folate-metabolizing genes and risk of non-Hodgkin's lymphoma.	MTHFD1 MTRR	6.13e-05	6	71	2	21055808
Pubmed	Lack of association of polymorphisms in homocysteine metabolism genes with pseudoexfoliation syndrome and glaucoma.	MTHFD1 MTRR	6.13e-05	6	71	2	19112534
Pubmed	Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance.	DUSP9 IRS1	6.13e-05	6	71	2	18296638
Pubmed	Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels.	HNF1A ABCA1	6.13e-05	6	71	2	20394740
Pubmed	Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.	MTHFD1 MTRR	6.13e-05	6	71	2	20056620
Pubmed	E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly.	DSG2 DSP	6.13e-05	6	71	2	20859650
Pubmed	Evaluation of folate metabolism gene polymorphisms as risk factors for open and closed neural tube defects.	MTHFD1 MTRR	6.13e-05	6	71	2	19533788
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	GMPS MTHFD1 MTHFD2 POR DLAT ACAA2 CHID1 NDUFB6 HSPA2	6.21e-05	859	71	9	31536960
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	VPS13D DSG2 DSP KMT2A GIGYF2 AKAP13 FRYL IRS1 AQR	6.32e-05	861	71	9	36931259
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	GMPS FBXO22 DSG2 ACAT2 DSP MTHFD1 MTHFD2 DUSP9 DLAT	7.34e-05	878	71	9	37223481
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	MON2 TDRKH PNPLA6 MTHFD2 DUSP9 ACAA2 NDUFB6 SIRT3	7.84e-05	686	71	8	28380382
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 NDOR1 PNPLA6 ZNF628 PTPRS C15orf39 AKAP13 FRYL IRS1 PHC2	8.01e-05	1105	71	10	35748872
Pubmed	The Long Noncoding RNA Pnky Is a Trans-acting Regulator of Cortical Development In Vivo.	NDOR1 POU3F2	8.57e-05	7	71	2	31112699
Pubmed	Loss of MLL Induces Epigenetic Dysregulation of Rasgrf1 to Attenuate Kras-Driven Lung Tumorigenesis.	NDOR1 KMT2A	8.57e-05	7	71	2	36098964
Pubmed	Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia.	MTHFD1 MTRR	8.57e-05	7	71	2	15797993
Pubmed	Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis.	MTHFD1 MTRR	8.57e-05	7	71	2	19706844
Pubmed	Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.	DSG2 DSP	8.57e-05	7	71	2	15479741
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	MTHFD1 DACH1 CSTF3 GIGYF2 ACAA2 SNRPA NDUFB6 HSPA2 CSTF2T	1.06e-04	922	71	9	27609421
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	TDRKH ACAT2 MTHFD1 MTHFD2 MTHFD2L DLAT ACAA2 NDUFB6 SIRT3	1.10e-04	926	71	9	20877624
Pubmed	Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway.	ANK3 DSG2	1.14e-04	8	71	2	28826662
Pubmed	Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia.	MTHFD1 MTRR	1.14e-04	8	71	2	19020309
Pubmed	Genome-wide association study reveals two new risk loci for bipolar disorder.	ANK3 POU3F2	1.14e-04	8	71	2	24618891
Pubmed	HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage.	DSP DLAT	1.14e-04	8	71	2	31537781
Pubmed	Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage.	DSG2 DSP	1.14e-04	8	71	2	9864371
Interaction	RYR3 interactions	HNF1A FBXO22 DSP UGGT1	1.42e-06	24	71	4	int:RYR3
Interaction	PAPOLA interactions	MTHFD1 CSTF3 SNRPA HSPA2 CSTF2T	1.82e-05	92	71	5	int:PAPOLA
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	PNPLA6 GATAD2A PTPRS BEST2 ARHGEF18 ADGRE2 ZNF653	2.35e-04	797	71	7	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr14q23	MTHFD1 HSPA2 ARMH4	1.10e-03	130	71	3	chr14q23
Cytoband	15q24.2	FBXO22 C15orf39	1.14e-03	32	71	2	15q24.2
Cytoband	9q32	C9orf43 KIF12	2.44e-03	47	71	2	9q32
Cytoband	Ensembl 112 genes in cytogenetic band chr9q32	C9orf43 KIF12	2.75e-03	50	71	2	chr9q32
Coexpression	PILON_KLF1_TARGETS_UP	GMPS COL5A2 ABCA1 ANK3 MTHFD2 DUSP9 KMT2A DLAT GIGYF2 FRYL	1.00e-06	503	71	10	M2226
Coexpression	PILON_KLF1_TARGETS_UP	GMPS COL5A2 ABCA1 ANK3 MTHFD2 DUSP9 KMT2A DLAT GIGYF2 FRYL	1.93e-06	541	71	10	MM1061
Coexpression	WU_ALZHEIMER_DISEASE_DN	DEFB4A ANK3 HSPA2	1.79e-05	19	71	3	M13334
Coexpression	NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP	ABCA1 ANK3 DSP RBM15B FRYL SRBD1 SNRPA AQR	4.29e-05	475	71	8	M40979
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_1000	CACNA1B HOXA13 COL5A2 COL24A1 ABCA1 DSG2 DSP DACH1 CSTF3 GIGYF2 AKAP13	4.62e-05	769	71	11	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_emap-30875_k-means-cluster#1_top-relative-expression-ranked_200	CACNA1B HOXA13 ARMH4	5.27e-05	22	71	3	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_200_k1
CoexpressionAtlas	facebase_RNAseq_e9.5_MandArch_2500_K3	PCED1B TUBGCP6 ZSWIM8 NDOR1 ZNF628 ANK3 MTHFD2 DUSP9 RBM15B MTHFD2L C15orf39 SNRPA RBM20 SF1	6.16e-05	1259	71	14	facebase_RNAseq_e9.5_MandArch_2500_K3
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_500	CACNA1B HOXA13 ABCA1 ANK3 DSP DACH1 GIGYF2 ARMH4	6.30e-05	407	71	8	gudmap_developingLowerUrinaryTract_e14.5_ urethra_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_1000	CACNA1B HOXA13 ABCA1 GATAD2A ANK3 DSG2 DSP PTPRS DACH1 C15orf39 ARMH4	8.04e-05	818	71	11	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor\|bone_marrow / Manually curated celltypes from each tissue	COL24A1 SDK2 DSG2 NYNRIN KIF12	4.07e-06	149	71	5	078e1e5765e476ba85c23fb8f6892b6698cbcbdb
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VPS13D DUSP9 IRS1 AQP4 HSPA2	6.30e-06	163	71	5	cab65dabeea58141c649e4fec5e0123beb3de1b3
ToppCell	CTRL-Lymphoid-pDC\|Lymphoid / Disease state, Lineage and Cell class	COL24A1 SDK2 DSG2 PTPRS DACH1	8.65e-06	174	71	5	ff4315e9fad198cc323fc987deb8652da137cf98
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L5-6_FEZF2_ANKRD20A1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL24A1 DSG2 DACH1 SDK1 RBM20	8.65e-06	174	71	5	99eb5e1aee136c7039e23b68a43a0fa3d775859f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PCED1B ANK3 KMT2A EDA SF1	1.13e-05	184	71	5	5350b58aa9979631228835d11eb45ddf81d08bff
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A2 SDK2 PTPRS ADGRE2 SDK1	1.29e-05	189	71	5	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	COL5A2 SDK2 PTPRS DACH1 SDK1	1.43e-05	193	71	5	acad568621ed677031797b8c2e34dafea798d681
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-HSC-MPP\|bone_marrow / Manually curated celltypes from each tissue	C9orf43 DSG2 NYNRIN DACH1 CHID1	1.46e-05	194	71	5	3a7e7acbddc63da44d9a04a5b52adf6934fc83dd
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 UGGT1 KIF12 KMT2A FRYL	1.50e-05	195	71	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 UGGT1 KIF12 KMT2A FRYL	1.50e-05	195	71	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Basal_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SDK2 DSP NYNRIN DUSP9 IRS1	1.54e-05	196	71	5	3b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A2 DSG2 PTPRS POR AQP4	1.54e-05	196	71	5	2029f58ce6a7b8c35d3a7496c3341391990909ce
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GLOD5 ANK3 KMT2A FRYL SF1	1.58e-05	197	71	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	mild-CD4+_T_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PCED1B ANK3 KMT2A EDA SF1	1.65e-05	199	71	5	3e4baaf4ee23f257d821194468102c00a8ad2f21
ToppCell	COVID-19-COVID-19_Mild-Others-HSPC\|COVID-19_Mild / Disease, condition lineage and cell class	COL24A1 C9orf43 DSG2 NYNRIN DACH1	1.65e-05	199	71	5	0230103c37ae3aff58240739b89f2c36b1e39a69
ToppCell	CTRL-Lymphoid-pDC\|CTRL / Disease state, Lineage and Cell class	COL24A1 SDK2 PTPRS DACH1	7.22e-05	139	71	4	bbc10812b0c5b8c85e78171c12316becde8895c3
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated\|lymph-node_spleen / Manually curated celltypes from each tissue	EDA HSPA2 SF1 SIRT3	9.45e-05	149	71	4	32b0a8789d3be4889821afab0b52214deeff7e4d
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1B MIGA2 DSG2 DSP	1.16e-04	157	71	4	4766f7d545bf2d775390589460677519cb92f4d5
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	COL5A2 SDK2 PTPRS NYNRIN	1.21e-04	159	71	4	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	TCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma-Usual_Type-6\|TCGA-Adrenal / Sample_Type by Project: Shred V9	GLOD5 DSG2 DUSP9 EDA	1.30e-04	162	71	4	0e8fb83acb8ea9905cc3ca985feb8a00931549ff
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	ANK3 MTRR AKAP13 AQP4	1.37e-04	164	71	4	beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	COL5A2 COL24A1 DSG2 ARMH4	1.37e-04	164	71	4	9b4a6007abae992db871d9f6f731d5af724de30d
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	ANK3 MTRR AKAP13 AQP4	1.37e-04	164	71	4	d005cfd821b87548b075120bffe65a0be9860463
ToppCell	severe-HSPC\|severe / disease stage, cell group and cell class	COL24A1 C9orf43 DSG2 NYNRIN	1.40e-04	165	71	4	acd837d88ad3786c263f74651a6c0e02fa2fa2c5
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PNPLA6 ANK3 ARHGEF18 NLRC3	1.43e-04	166	71	4	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PNPLA6 ANK3 ARHGEF18 NLRC3	1.43e-04	166	71	4	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRS UGGT1 DUSP9 AQR	1.47e-04	167	71	4	e0f2509e86302eca8352821bce12597f6c51fc24
ToppCell	facs-Lung-EPCAM-24m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRS UGGT1 DUSP9 AQR	1.47e-04	167	71	4	b25646b6653cd8814dbeae4c74ce899ede105200
ToppCell	10x5'-Lung-Myeloid_Dendritic-pDC\|Lung / Manually curated celltypes from each tissue	COL24A1 SDK2 PTPRS DACH1	1.50e-04	168	71	4	90f713dae3fcbd6ca801a019e3861c263ff3366b
ToppCell	NS-moderate-d_07-13-Myeloid-pDC\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	COL24A1 SDK2 PTPRS DACH1	1.50e-04	168	71	4	d03e91f0e0518b33555c0ec98124fc5ed0f11be5
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL24A1 SDK2 DACH1 RBM20	1.50e-04	168	71	4	7abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCell	severe-HSPC\|World / disease stage, cell group and cell class	COL24A1 C9orf43 DSG2 NYNRIN	1.53e-04	169	71	4	b0421b73bfdc92f7a2762b4b670b9eae124aa702
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL5A2 COL24A1 DSG2 RBM20	1.53e-04	169	71	4	d0c64ca31053dfc283a07d5ad1117ca7dc1777a7
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL5A2 COL24A1 DSG2 RBM20	1.53e-04	169	71	4	d79abfbeffd082a4fbffbc1051ffc474374874fa
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B DSP KIF12 POU3F2	1.57e-04	170	71	4	6a98f47f8c2b5b15e09169bd82eff1e6bf76e5a6
ToppCell	10x5'-blood-Myeloid_Dendritic-pDC\|blood / Manually curated celltypes from each tissue	COL24A1 SDK2 PTPRS DACH1	1.57e-04	170	71	4	59cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GMPS HOXA13 GLOD5 AQP4	1.57e-04	170	71	4	833b4f44ea1fa673dfc6b43ce45a79fe68ae3b05
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL24A1 SDK2 PTPRS ZNF653	1.60e-04	171	71	4	39c8ae139e449217091e1481eb5e2aafb8f69a1c
ToppCell	mild_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	COL24A1 DSG2 PTPRS DACH1	1.64e-04	172	71	4	dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L5-6_FEZF2_ANKRD20A1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL24A1 DSG2 DACH1 RBM20	1.64e-04	172	71	4	ddecdb1a0791296929790f78b49008f51a130f8b
ToppCell	Healthy_donor-HSPC\|Healthy_donor / disease group, cell group and cell class (v2)	COL5A2 C9orf43 NYNRIN DACH1	1.64e-04	172	71	4	bc7549faadfc92c683c0e26bea380458706774b5
ToppCell	droplet-Fat-Gat-18m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNF1A DSG2 KIF12 AQP4	1.68e-04	173	71	4	f3f67531f72d6d52e19c7f1f2db1ab4026fb70da
ToppCell	droplet-Fat-Gat-18m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNF1A DSG2 KIF12 AQP4	1.68e-04	173	71	4	a40a52d8041d45dc3bef74fe55945ae07aa018d6
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NYNRIN DUSP9 KIF12 HSPA2	1.68e-04	173	71	4	7a3115e7cf7e2f345192cde0656a7f0193594a5f
ToppCell	droplet-Fat-Gat-18m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNF1A DSG2 KIF12 AQP4	1.68e-04	173	71	4	f0b4dd1cf41d6ee6abb0e1968b8b39f4fabebcb5
ToppCell	BAL-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	COL24A1 DSG2 PTPRS DACH1	1.72e-04	174	71	4	ab654e87c7eab7f33adc61be7a86da5c4d88008d
ToppCell	BAL-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	COL24A1 DSG2 PTPRS DACH1	1.72e-04	174	71	4	d9bccff5258c4277bdd1edbd87e17c327ec125e8
ToppCell	BAL-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	COL24A1 DSG2 PTPRS DACH1	1.72e-04	174	71	4	2453419842fd22d066631615403393bfe4449bb8
ToppCell	mild_COVID-19-pDC\|mild_COVID-19 / disease group, cell group and cell class (v2)	COL24A1 DSG2 PTPRS DACH1	1.75e-04	175	71	4	b87f279a7519710146c49d6acccb0adedc195965
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL24A1 SDK2 SDK1 RBM20	1.75e-04	175	71	4	90e29945aa861082c94bb4f331161adc3a6ef899
ToppCell	BAL-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL24A1 DSG2 PTPRS DACH1	1.75e-04	175	71	4	6d5bdfbe53608e01c3845ecd908ca6d0fecc58f8
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HNF1A DSG2 DSP KIF12	1.75e-04	175	71	4	6759d200a133034756de9cdf2d5daceca927aac9
ToppCell	BAL-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL24A1 DSG2 PTPRS DACH1	1.75e-04	175	71	4	6839ee3bb4457d13cb08ca8eb79ae33ddd256783
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ABCA1 ACAT2 ADGRE2 SIRT3	1.75e-04	175	71	4	da191dfb8a7f976a632a3a0b923942ab54f5c8c1
ToppCell	BAL-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL24A1 DSG2 PTPRS DACH1	1.75e-04	175	71	4	9d6135e183179968555670abec39dff9da2c3219
ToppCell	Control-Myeloid-pDC\|Control / Disease group,lineage and cell class （2021.01.30）	COL24A1 DSG2 PTPRS DACH1	1.79e-04	176	71	4	baa3563973ea1a351fe028f55828463d2a51bf1a
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL24A1 DACH1 AKAP13 RBM20	1.79e-04	176	71	4	72a2a01618ce836bc843395d5095e9090759b4a6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL24A1 SDK2 SDK1 RBM20	1.79e-04	176	71	4	e4b21fd6a5e0c5950f27c3e1868318e48330ae5e
ToppCell	368C-Epithelial_cells-Epithelial-B_(AT2)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	GLOD5 SDK2 DSG2 DSP	1.83e-04	177	71	4	ac8f774596068e66c0a9ea8a318be0ce5f5df834
ToppCell	Control-Myeloid-pDC\|Control / Disease state, Lineage and Cell class	COL24A1 SDK2 DSG2 PTPRS	1.83e-04	177	71	4	3940663bb5b45b2ca9f772550380a516c53e410b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL5A2 COL24A1 DSG2 RBM20	1.83e-04	177	71	4	a25ca82c4bda033ee113f8ecb4a541b22e7a29ca
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SDK2 DSG2 AKAP13 RBM20	1.83e-04	177	71	4	57033ee0d49a4a50fc25328a4a44d4de2b35f505
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL5A2 COL24A1 DSG2 RBM20	1.83e-04	177	71	4	fbead6e56271b1f1d447f89857de444ebe7157b0
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	C9orf43 NDOR1 DSG2 DACH1	1.83e-04	177	71	4	844017225e9039d1bc621a9630a30c2e9a51b36d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL24A1 SDK2 DACH1 RBM20	1.83e-04	177	71	4	4c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL24A1 SDK2 DACH1 SDK1	1.83e-04	177	71	4	bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCell	Control-Myeloid-pDC\|Myeloid / Disease state, Lineage and Cell class	COL24A1 SDK2 DSG2 PTPRS	1.83e-04	177	71	4	e82115bfc32c7b689460fbc5caeb983c1aabe30f
ToppCell	368C-Epithelial_cells-Epithelial-B_(AT2)\|368C / Donor, Lineage, Cell class and subclass (all cells)	GLOD5 SDK2 DSG2 DSP	1.83e-04	177	71	4	d9c4a93b0e04a13bf39992dd1c1ec8df2c5f89fe
ToppCell	Control-Myeloid-pDC\|World / Disease state, Lineage and Cell class	COL24A1 SDK2 PTPRS DACH1	1.87e-04	178	71	4	20ef63d925e67ddd5955832312ca8574a6f838a4
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 SDK2 UGGT1 IRS1	1.87e-04	178	71	4	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2-Exc_L5_FEZF2_MORN2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL5A2 COL24A1 DSG2 RBM20	1.87e-04	178	71	4	b0fc56f583cb3f2977fe2306994c0d478c9a6b1b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL5A2 COL24A1 SDK2 SDK1	1.91e-04	179	71	4	7954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL24A1 SDK2 DACH1 RBM20	1.91e-04	179	71	4	f65889bf1e41396979cce44a5e63f49dea2bbd9b
ToppCell	IPF-Myeloid-pDC\|Myeloid / Disease state, Lineage and Cell class	COL24A1 SDK2 DSG2 PTPRS	1.95e-04	180	71	4	0f8567aa835d4e3a52f6631ae15216eca18a030c
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL5A2 COL24A1 ABCA1 SDK1	1.95e-04	180	71	4	f2f6e83127a4a415e65c76a35efa8175fbd5b5d9
ToppCell	moderate-Myeloid-pDC\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	COL24A1 SDK2 PTPRS DACH1	1.95e-04	180	71	4	a0751ad5e42a21cb107d900abfa9ee967a0069fc
ToppCell	NS-moderate-d_16-33-Myeloid-pDC\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	COL24A1 SDK2 PTPRS DACH1	1.95e-04	180	71	4	144818e69613296cde43f29cb8c20899c670b319
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(INS+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GLOD5 DSP KIF12 POU3F2	1.95e-04	180	71	4	0c5d9245b8a7cc34ad52522d31559906cda55bdf
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL24A1 SDK2 DACH1 SDK1	1.99e-04	181	71	4	08f44323bf71b6004a921bbc969c954c75feeb66
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAT2 PTPRS IRS1 ARMH4	1.99e-04	181	71	4	4e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAT2 PTPRS IRS1 ARMH4	1.99e-04	181	71	4	ad30c01290fb98adbd0caed301a584761212c977
ToppCell	3'_v3-Lung-Myeloid_Dendritic-pDC\|Lung / Manually curated celltypes from each tissue	COL24A1 SDK2 DSG2 PTPRS	1.99e-04	181	71	4	3d7f089fb434fbc989f1fa159e22133ae00b2487
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXA13 DEFB4A KIF12 ACAA2	1.99e-04	181	71	4	bec917f6f56ae252639a5a76024be5df5c70a6d5
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAT2 PTPRS IRS1 ARMH4	1.99e-04	181	71	4	3a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	COL24A1 C9orf43 DSG2 NYNRIN	2.04e-04	182	71	4	6497eeafb2b137e70261ec0314782831892a940d
ToppCell	Control-Hematopoietic_SC-HSPC\|Control / Disease group, lineage and cell class	COL24A1 C9orf43 DSG2 NYNRIN	2.04e-04	182	71	4	14e347c0e6444410f1948851407bb18c706569f4
ToppCell	Control-Hematopoietic_SC\|Control / Disease group, lineage and cell class	COL24A1 C9orf43 DSG2 NYNRIN	2.04e-04	182	71	4	43243c6bae2ac7fa3fd1f193a17f61ee4d938ea9
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL24A1 C9orf43 DSG2 NYNRIN	2.04e-04	182	71	4	d0ebf2f0d5370458ab81485a0017c311077133d5
ToppCell	PBMC-Control-Hematopoietic-HSPC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	COL24A1 C9orf43 DSG2 NYNRIN	2.04e-04	182	71	4	bd1626261803324084fafca2f6665b50854e7fae
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL24A1 C9orf43 DSG2 NYNRIN	2.04e-04	182	71	4	2a6d1246bfb5899a0861c7f2f8fb9b43b0df8acc
ToppCell	PBMC-Control-Hematopoietic-HSPC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL24A1 C9orf43 DSG2 NYNRIN	2.04e-04	182	71	4	918286422b3eab32d962b49aa07b1b9512e51d9d
ToppCell	PBMC-Control-Hematopoietic-HSPC-HSPC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	COL24A1 C9orf43 DSG2 NYNRIN	2.04e-04	182	71	4	0d9b8c900da8cbae9cde72aecd4026b1ac2bbd67
ToppCell	Basal\|World / shred by cell class for mouse tongue	ABCA1 DSG2 MTHFD1 PTPRS	2.08e-04	183	71	4	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	COVID-19-Epithelial_cells-ECM-high_epithelial\|COVID-19 / group, cell type (main and fine annotations)	COL5A2 ANK3 DSG2 DSP	2.08e-04	183	71	4	dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL24A1 SDK2 DACH1 RBM20	2.08e-04	183	71	4	65f2a5895d166189a095cf7ea9dda171f0419b08
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|normal_Lung / Location, Cell class and cell subclass	COL5A2 COL24A1 IRS1 ARMH4	2.12e-04	184	71	4	0b336489c10e8c3c957795dd845454f03404382b
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3\|TCGA-Lung / Sample_Type by Project: Shred V9	CACNA1B SDK2 PTPRS SDK1	2.12e-04	184	71	4	ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
ToppCell	droplet-Thymus-nan-18m-Myeloid-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK3 DSG2 DSP KIF12	2.26e-04	187	71	4	ed69e7cbd6fb59363b0e26f24887fc49405397ce
ToppCell	CF-Lymphoid-pDC\|Lymphoid / Disease state, Lineage and Cell class	COL24A1 SDK2 DSG2 PTPRS	2.26e-04	187	71	4	adc79e5804ab98006dbdf1d76ef0d8f85cc5cb0f
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GATAD2A ANK3 NYNRIN KMT2A	2.31e-04	188	71	4	6468fa95ad0395395301115286f2d8c0df5d3882
Disease	Neural tube defects, folate-sensitive	MTHFD1 MTRR	3.22e-05	4	69	2	cv:C1866558
Disease	Neural tube defect, folate-sensitive	MTHFD1 MTRR	3.22e-05	4	69	2	C1866558
Disease	NEURAL TUBE DEFECTS, FOLATE-SENSITIVE	MTHFD1 MTRR	3.22e-05	4	69	2	601634
Disease	smoking status measurement, Cannabis use, schizophrenia	POU3F2 SDK1 PHC2	4.28e-05	29	69	3	EFO_0006527, EFO_0007585, MONDO_0005090
Disease	glutamate measurement	HNF1A POU3F2 NDUFB6	4.28e-05	29	69	3	EFO_0010487
Disease	spina bifida (is_implicated_in)	MTHFD1 MTRR	8.03e-05	6	69	2	DOID:0080016 (is_implicated_in)
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	HNF1A ABCA1 NYNRIN ACAA2	8.72e-05	99	69	4	EFO_0004611, EFO_0007878
Disease	blood urea nitrogen measurement	HOXA13 HNF1A DUSP9 DACH1 POR AKAP13 PHC2	8.99e-05	452	69	7	EFO_0004741
Disease	coronary artery disease (is_implicated_in)	HNF1A ABCA1 ACAT2 IRS1	9.07e-05	100	69	4	DOID:3393 (is_implicated_in)
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	HNF1A ABCA1 NYNRIN ACAA2	9.79e-05	102	69	4	EFO_0004329, EFO_0004611
Disease	creatinine measurement	HOXA13 HNF1A FBXO22 DUSP9 DACH1 POR ARHGEF18 GIGYF2 NLRC3 PHC2	1.02e-04	995	69	10	EFO_0004518
Disease	Arrhythmogenic right ventricular cardiomyopathy	DSG2 DSP	1.12e-04	7	69	2	cv:C0349788
Disease	premature menopause (biomarker_via_orthology)	ABCA1 ACAT2	1.50e-04	8	69	2	DOID:10787 (biomarker_via_orthology)
Disease	saturated fatty acids measurement	HNF1A ABCA1 ACAA2	1.62e-04	45	69	3	EFO_0022304
Disease	Cardiomyopathy	DSG2 DSP RBM20	1.84e-04	47	69	3	cv:C0878544
Disease	triglycerides in HDL measurement	HNF1A ABCA1 ACAA2	2.64e-04	53	69	3	EFO_0022317
Disease	Peripheral Nervous System Diseases	CACNA1B ABCA1 PNPLA6	2.79e-04	54	69	3	C4721453
Disease	triglycerides in very large HDL measurement	HNF1A ABCA1 ACAA2	2.94e-04	55	69	3	EFO_0022324
Disease	factor VII measurement	HNF1A SDK1 SF1	2.94e-04	55	69	3	EFO_0004619
Disease	anxiety disorder, stress-related disorder	GIGYF2 SDK1	3.50e-04	12	69	2	EFO_0006788, EFO_0010098
Disease	free cholesterol to total lipids in medium HDL percentage	HNF1A ABCA1 ACAA2	3.81e-04	60	69	3	EFO_0022282
Disease	Cannabis use	CHID1 SDK1	6.33e-04	16	69	2	EFO_0007585
Disease	non-Hodgkin lymphoma (is_implicated_in)	MTRR KMT2A	7.16e-04	17	69	2	DOID:0060060 (is_implicated_in)
Disease	extrahepatic cholestasis (biomarker_via_orthology)	HNF1A ABCA1	7.16e-04	17	69	2	DOID:13619 (biomarker_via_orthology)
Disease	phospholipid measurement, high density lipoprotein cholesterol measurement	HNF1A ABCA1 NYNRIN ACAA2 ARMH4	9.39e-04	321	69	5	EFO_0004612, EFO_0004639
Disease	lipoprotein measurement, phospholipid measurement	HNF1A ABCA1 NYNRIN	1.05e-03	85	69	3	EFO_0004639, EFO_0004732
Disease	lipid measurement, high density lipoprotein cholesterol measurement	HNF1A ABCA1 NYNRIN ACAA2 ARMH4	1.06e-03	330	69	5	EFO_0004529, EFO_0004612
Disease	level of Phosphatidylcholine (18:1_20:4) in blood serum	ABCA1 GATAD2A	1.10e-03	21	69	2	OBA_2045104
Disease	level of Phosphatidylinositol (18:0_18:2) in blood serum	HNF1A ACAA2	1.10e-03	21	69	2	OBA_2045156
Disease	lipid measurement, lipoprotein measurement	HNF1A ABCA1 NYNRIN	1.24e-03	90	69	3	EFO_0004529, EFO_0004732
Disease	Coronary heart disease	HNF1A IRS1	1.44e-03	24	69	2	C0010068
Disease	Antiglaucoma preparations and miotics use measurement	ABCA1 KMT2A	1.69e-03	26	69	2	EFO_0009944
Disease	azoospermia (implicated_via_orthology)	TDRKH PTPRS	1.82e-03	27	69	2	DOID:14227 (implicated_via_orthology)
Disease	TYPE 2 DIABETES MELLITUS	HNF1A IRS1	1.96e-03	28	69	2	125853
Disease	Type 2 diabetes mellitus	HNF1A IRS1	1.96e-03	28	69	2	cv:C0011860
Disease	hepatocellular carcinoma (biomarker_via_orthology)	GMPS ABCA1 MTHFD2	2.10e-03	108	69	3	DOID:684 (biomarker_via_orthology)
Disease	Primary familial dilated cardiomyopathy	DSG2 RBM20	2.25e-03	30	69	2	cv:C0340427
Disease	triacylglycerol 50:4 measurement	GATAD2A DACH1	2.25e-03	30	69	2	EFO_0010411
Disease	ceramide measurement	HNF1A ABCA1 GATAD2A SDK1	2.26e-03	235	69	4	EFO_0010222
Disease	triglyceride measurement, intermediate density lipoprotein measurement	HNF1A ABCA1 NYNRIN	2.27e-03	111	69	3	EFO_0004530, EFO_0008595

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGTTPGPLGRIVEFM	C2orf16	461	Q68DN1
VTPPSVVGGLGVTMV	AQP4	136	P55087
GPVEPFSIVTMPGPR	BEST2	476	Q8NFU1
PAGPGTQLGPITGEM	ARHGEF18	361	Q6ZSZ5
EGPRVSMLPSGVGPE	ARHGEF18	1176	Q6ZSZ5
DPGPSVVGLVSIPGM	ADGRE2	396	Q9UHX3
VLGSPVTPPGIMVGE	ARMH4	556	Q86TY3
VTPPGIMVGEPSISP	ARMH4	561	Q86TY3
GGPPVVFLDEPTTGM	ABCA1	2061	O95477
VTDPQGVGTPEMIPL	AKAP13	1141	Q12802
PGLTMVVGPPGTGKT	AQR	816	O60306
GLMSPGIIPPTGLTA	DACH1	311	Q9UI36
PVMLTGPLGEATVVP	CACNA1B	1081	Q00975
MPLPGVFGGIGDPVT	DEFB4A	16	O15263
PSGLGTEGMPTVEPG	RBM15B	801	Q8NDT2
GVMPQTPGQPAVILG	RBM20	201	Q5T481
VTGSTMPPTTVILGP	DSG2	941	Q14126
MRVTPEPGAGPTQGL	GATAD2A	46	Q86YP4
LGIVTPGIVVTPMGS	FBXO22	146	Q8NEZ5
PVPFVPQVLGVMIGA	PNPLA6	51	Q8IY17
TPVIMVGPGTGVAPF	POR	526	P16435
VPPRVSITIGVAGMG	NLRC3	136	Q7RTR2
EEGPVPRTGAKGPIM	GLOD5	126	A6NK44
GEGVPVPPSLAGIMQ	KIF12	121	Q96FN5
PSIPIIMVGPGTGIA	MTRR	536	Q9UBK8
PLSLGIETAGGVMTP	HSPA2	401	P54652
GMAPVPTGVFTDIPI	DLAT	411	P10515
MPVGEEVTGGFLPPK	PCED1B	166	Q96HM7
PGDTILETGEVIPPM	NDUFB6	106	O95139
PGGVFPVPPAAVVLM	CSTF3	606	Q12996
GEPPMPTTGVILPSG	FRYL	466	O94915
AGSSMAPVPGPVPVV	DUSP9	146	Q99956
ASLPGVMTIGPGEPA	HNF1A	406	P20823
VMTIGPGEPASLGPT	HNF1A	411	P20823
GPEMGGEQLGTVPLP	MIGA2	76	Q7L4E1
PVGPGAEPSVQTGMV	TUBGCP6	901	Q96RT7
VNVPVPVLIGPISGM	MON2	1191	Q7Z3U7
ESTGVEMGRLGPAPP	IRS1	956	P35568
PETPDTPVIMVGPGT	NDOR1	446	Q9UHB4
TPVIMVGPGTGVAPF	NDOR1	451	Q9UHB4
GPGMVSVVGPMGLLV	PTPRS	6	Q13332
GIPGIPGIPGTTVMG	EDA	201	Q92838
MTGIPATPGNEIPVE	GMPS	646	P49915
TLRPVETPVVGAPGM	GIGYF2	461	Q6Y7W6
GTRVGTPGMIVPPPT	C9orf43	176	Q8TAL5
TGPGGVDMLVPSVGL	DSP	496	P15924
ITMTIPVPPPSGEGV	ANK3	1216	Q12955
SQVGLMPGSVGPVGP	COL5A2	206	P05997
EMGGLGILTSVPITP	KMT2A	1416	Q03164
GMPGVGPVPLERGQV	CSTF2T	291	Q9H0L4
GTPETMAPTIVVPPG	SDK1	286	Q7Z5N4
PGPPMGILFPEVRTT	SDK2	1301	Q58EX2
SFITPVPGGVGPMTV	MTHFD1	266	P11586
VIPPAITPGTDQLGM	CHID1	226	Q9BWS9
VPGPPGSLMVGGLTE	NYNRIN	111	Q9P2P1
TPVPGGVGPMTVAML	MTHFD2	306	P13995
VVMVGAGISTPSGIP	SIRT3	141	Q9NTG7
RMTPPGGTLPGAEDV	POU3F2	411	P20265
DMPVVPGLGGPGESR	HOXA13	251	P31271
TSPVPGRTLMGVDPG	SRBD1	531	Q8N5C6
PGLPGVPVTTDAMPR	C15orf39	626	Q6ZRI6
IGETGPVGLPGEVGM	COL24A1	851	Q17RW2
GCDPSIMGIGPVPAI	ACAA2	286	P42765
IVTAMPGGLPVPTSP	PHC2	496	Q8IXK0
PGMVPGSQVIIIAGP	ZNF653	311	Q96CK0
VTPPPKGGGDMAVVV	TDRKH	251	Q9Y2W6
VGVEPSIMGIGPIPA	ACAT2	286	Q9BWD1
GVPVPAAPGLIGNVM	SMAP1	346	Q8IYB5
AGFITPVPGGVGPMT	MTHFD2L	316	Q9H903
PVPGGVGPMTVAMLL	MTHFD2L	321	Q9H903
MPEGRGGPGTEPVTV	ZSWIM8	1456	A7E2V4
TVIPGMPTVIPPGLT	SF1	31	Q15637
TPVVGAVQGPVPGMP	SNRPA	131	P09012
TGVGPLPVVLFNGMP	UGGT1	626	Q9NYU2
QAMLEPGEVVVPGPV	ZNF783	391	Q6ZMS7
VVPAGAGPGVMTPQG	ZNF628	1026	Q5EBL2
PGSGMLSIRVIPDGP	VPS13D	3771	Q5THJ4