Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionzinc ion transmembrane transporter activity

SLC39A6 SLC39A10 SLC39A9 SLC39A7

4.31e-0824304GO:0005385
GeneOntologyMolecularFunctiontransition metal ion transmembrane transporter activity

SLC39A6 SLC39A10 SLC39A9 SLC39A7

5.39e-0744304GO:0046915
GeneOntologyMolecularFunctionmonoatomic cation:bicarbonate symporter activity

SLC39A6 SLC39A10

1.68e-0413302GO:0140410
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

GABRQ SLC39A6 SLC39A10 SLC39A9 SLC39A7 UNC80

1.01e-03793306GO:0015075
GeneOntologyMolecularFunctionbicarbonate transmembrane transporter activity

SLC39A6 SLC39A10

1.05e-0332302GO:0015106
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

CRIM1 CLK2 CLK3

1.32e-03145303GO:0004713
GeneOntologyMolecularFunctionprotein serine/threonine/tyrosine kinase activity

CLK2 CLK3

2.26e-0347302GO:0004712
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC39A6 SLC39A10 SLC39A9 SLC39A7 UNC80

2.86e-03664305GO:0008324
GeneOntologyBiologicalProcesszinc ion transmembrane transport

SLC39A6 SLC39A10 SLC39A9 SLC39A7

6.30e-0829284GO:0071577
GeneOntologyBiologicalProcesszinc ion transport

SLC39A6 SLC39A10 SLC39A9 SLC39A7

7.26e-0830284GO:0006829
GeneOntologyBiologicalProcessintracellular zinc ion homeostasis

SLC39A6 SLC39A10 SLC39A9 SLC39A7

3.55e-0744284GO:0006882
GeneOntologyBiologicalProcesstransition metal ion transport

SLC39A6 SLC39A10 SLC39A9 SLC39A7

1.58e-05113284GO:0000041
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

HRC SLC39A6 SLC39A10 SLC39A9 SPP1 SLC39A7 UNC80

3.34e-05705287GO:0055080
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

HRC SLC39A6 SLC39A10 SLC39A9 SPP1 SLC39A7 UNC80

3.72e-05717287GO:0050801
GeneOntologyBiologicalProcesszinc ion import across plasma membrane

SLC39A6 SLC39A10

9.70e-0511282GO:0071578
GeneOntologyBiologicalProcesscellular response to testosterone stimulus

SLC39A9 SPP1

1.37e-0413282GO:0071394
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

HRC SLC39A6 SLC39A10 SLC39A9 SPP1 SLC39A7

1.42e-04611286GO:0030003
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

HRC SLC39A6 SLC39A10 SLC39A9 SPP1 SLC39A7

1.57e-04622286GO:0006873
GeneOntologyBiologicalProcessinorganic ion homeostasis

HRC SLC39A6 SLC39A10 SLC39A9 SPP1 SLC39A7

1.57e-04622286GO:0098771
GeneOntologyBiologicalProcesschemical homeostasis

HRC SLC39A6 SLC39A10 SLC39A9 SPP1 SCD SLC39A7 UNC80

1.85e-041249288GO:0048878
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

HRC GABRQ SLC39A6 SLC39A10 SLC39A9 SLC39A7 UNC80

5.75e-041115287GO:0034220
GeneOntologyBiologicalProcessintracellular chemical homeostasis

HRC SLC39A6 SLC39A10 SLC39A9 SPP1 SLC39A7

9.17e-04866286GO:0055082
HumanPhenoEnlarged naris

NSD1 UNC80

2.42e-05672HP:0009931
HumanPhenoBroad forehead

NSD1 ADAMTS3 UNC80 BRPF1

8.11e-0520574HP:0000337
MousePhenodecreased cardiac muscle relaxation

HRC NEBL

2.14e-055212MP:0020419
DomainZip

SLC39A6 SLC39A10 SLC39A9 SLC39A7

5.35e-0914304PF02535
DomainZIP

SLC39A6 SLC39A10 SLC39A9 SLC39A7

5.35e-0914304IPR003689
DomainPWWP

NSD1 BRPF1

4.65e-0420302SM00293
DomainPWWP

NSD1 BRPF1

6.18e-0423302PF00855
DomainPWWP_dom

NSD1 BRPF1

6.18e-0423302IPR000313
DomainPWWP

NSD1 BRPF1

6.73e-0424302PS50812
DomainZnf_FYVE_PHD

NSD1 WDFY2 BRPF1

1.66e-03147303IPR011011
DomainWD40_repeat_CS

WDHD1 TLE1 WDFY2

2.27e-03164303IPR019775
DomainZinc_finger_PHD-type_CS

NSD1 BRPF1

4.87e-0365302IPR019786
Domain-

NSD1 TRIM43 WDFY2 BRPF1

5.50e-034493043.30.40.10
DomainZnf_RING/FYVE/PHD

NSD1 TRIM43 WDFY2 BRPF1

5.95e-03459304IPR013083
DomainZnf_PHD-finger

NSD1 BRPF1

7.12e-0379302IPR019787
DomainWD40

WDHD1 TLE1 WDFY2

8.12e-03259303PF00400
DomainWD40

WDHD1 TLE1 WDFY2

8.91e-03268303SM00320
DomainPHD

NSD1 BRPF1

8.96e-0389302SM00249
DomainWD40_repeat

WDHD1 TLE1 WDFY2

9.28e-03272303IPR001680
DomainZnf_PHD

NSD1 BRPF1

9.35e-0391302IPR001965
DomainWD_REPEATS_1

WDHD1 TLE1 WDFY2

9.84e-03278303PS00678
DomainWD_REPEATS_2

WDHD1 TLE1 WDFY2

9.94e-03279303PS50082
DomainWD_REPEATS_REGION

WDHD1 TLE1 WDFY2

9.94e-03279303PS50294
DomainZF_PHD_2

NSD1 BRPF1

1.02e-0295302PS50016
DomainZF_PHD_1

NSD1 BRPF1

1.04e-0296302PS01359
DomainWD40_repeat_dom

WDHD1 TLE1 WDFY2

1.18e-02297303IPR017986
Domain-

WDHD1 TLE1 WDFY2

1.60e-023333032.130.10.10
DomainWD40/YVTN_repeat-like_dom

WDHD1 TLE1 WDFY2

1.62e-02335303IPR015943
PathwayWP_ZINC_HOMEOSTASIS

SLC39A6 SLC39A10 SLC39A9 SLC39A7

6.75e-0737274M39377
PathwayREACTOME_ZINC_INFLUX_INTO_CELLS_BY_THE_SLC39_GENE_FAMILY

SLC39A6 SLC39A10 SLC39A7

7.45e-0710273M27361
PathwayREACTOME_ZINC_TRANSPORTERS

SLC39A6 SLC39A10 SLC39A7

2.81e-0615273M832
PathwayREACTOME_METAL_ION_SLC_TRANSPORTERS

SLC39A6 SLC39A10 SLC39A7

1.23e-0524273M18795
PathwayREACTOME_ZINC_INFLUX_INTO_CELLS_BY_THE_SLC39_GENE_FAMILY

SLC39A6 SLC39A7

9.82e-058272MM15106
PathwayWP_NRF2_PATHWAY

SLC39A6 SLC39A10 SLC39A9 SLC39A7

1.41e-04141274M39454
PathwayREACTOME_ZINC_TRANSPORTERS

SLC39A6 SLC39A7

1.92e-0411272MM15101
PathwayWP_NUCLEAR_RECEPTORS_METAPATHWAY

SLC39A6 SLC39A10 SLC39A9 SCD SLC39A7

2.87e-04314275M39428
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC39A6 SLC39A10 SLC39A7

5.38e-0484273M27334
PathwayREACTOME_METAL_ION_SLC_TRANSPORTERS

SLC39A6 SLC39A7

6.57e-0420272MM15077
Pubmed

Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION.

SLC39A6 SLC39A7

7.19e-07230225969539
Pubmed

High glucose level promotes migration behavior of breast cancer cells through zinc and its transporters.

SLC39A6 SLC39A10

7.19e-07230224587242
Pubmed

Ermelin, an endoplasmic reticulum transmembrane protein, contains the novel HELP domain conserved in eukaryotes.

SLC39A6 SLC39A7

7.19e-07230211891044
Pubmed

Moderate zinc deficiency reduces testicular Zip6 and Zip10 abundance and impairs spermatogenesis in mice.

SLC39A6 SLC39A10

7.19e-07230221248196
Pubmed

Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration.

SLC39A6 SLC39A10

7.19e-07230227274087
Pubmed

The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.

CLK2 CLK3

7.19e-0723029637771
Pubmed

The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis.

SLC39A6 SLC39A10

2.16e-06330232797246
Pubmed

Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.

CLK2 CLK3

4.31e-0643027990150
Pubmed

Chromosomal mapping of three human LAMMER protein-kinase-encoding genes.

CLK2 CLK3

4.31e-0643029856501
Pubmed

Characterization and comparison of four serine- and arginine-rich (SR) protein kinases.

CLK2 CLK3

4.31e-0643029307018
Pubmed

A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.

SLC39A6 SLC39A10

4.31e-06430228098160
Pubmed

Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.

SLC39A6 SLC39A7

4.31e-06430212839489
Pubmed

Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.

CLK2 CLK3

7.18e-06530219168442
Pubmed

The LZT proteins; the LIV-1 subfamily of zinc transporters.

SLC39A6 SLC39A10

2.01e-05830212659941
Pubmed

Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis.

SLC39A6 SLC39A10

9.70e-051730229078349
Pubmed

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.

SLC39A6 SLC39A10 CLK3 SLC39A7

1.18e-0429630434186245
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

SLC39A6 SLC39A10 SLC39A9 SPP1 SCD TLE1 SLC39A7

1.90e-04145130730550785
Pubmed

Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling.

SCD TLE1

1.96e-042430215728386
Pubmed

Expression of Groucho/TLE proteins during pancreas development.

POU3F4 TLE1

1.96e-042430218778483
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

NSD1 WAPL SLC39A10 IK WDHD1 SCD

2.83e-04108430611544199
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

WAPL WDHD1 NEBL SCD TLE1

3.78e-0473330534672954
Pubmed

Diversification of stem cell molecular repertoire by alternative splicing.

CLK2 NUP210

4.20e-043530216183747
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

SLC39A6 SLC39A10 ZNF417 SCD SLC39A7 NUP210

4.92e-04120330629180619
Pubmed

Gene expression analysis of the embryonic subplate.

CRIM1 NEBL TLE1

6.40e-0419630321862448
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

WDHD1 SPP1 CLK2 NUP210

6.78e-0446930427634302
Pubmed

Genetic variations strongly influence phenotypic outcome in the mouse retina.

NSD1 TLE1

7.27e-044630221779340
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

WAPL IK SLC39A7 BRPF1 NUP210

7.28e-0484730535850772
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

CRIM1 WDFY2 NUP210

8.25e-0421430322199357
InteractionCCDC125 interactions

NSD1 NEBL ZNF417 ZNF587

2.86e-0667304int:CCDC125
InteractionNKAPL interactions

ZNF417 CLK3 ZNF587

5.90e-0624303int:NKAPL
InteractionCEP70 interactions

IK NEBL ZNF417 ZNF587 BRPF1

3.90e-05262305int:CEP70
InteractionRORB interactions

NSD1 ZNF417 ZNF587

4.62e-0547303int:RORB
InteractionTRIM27 interactions

TRIM43 TTC23 NEBL ZNF417 CLK2 ZNF587

9.43e-05514306int:TRIM27
InteractionBIVM-ERCC5 interactions

CLK2 CLK3

9.57e-0510302int:BIVM-ERCC5
GeneFamilyCDC like kinases

CLK2 CLK3

1.10e-054252480
GeneFamilyPWWP domain containing

NSD1 BRPF1

4.17e-04222521147
GeneFamilySolute carriers

SLC39A6 SLC39A10 SLC39A9 SLC39A7

1.97e-03395254752
GeneFamilyWD repeat domain containing

WDHD1 TLE1 WDFY2

5.47e-03262253362
GeneFamilyPHD finger proteins

NSD1 BRPF1

6.82e-039025288
Diseasecysteine-rich with EGF-like domain protein 1 measurement

BRPF1 NUP210

4.23e-0432282EFO_0021870
DiseaseAutism Spectrum Disorders

GABRQ UNC80

2.95e-0385282C1510586
Diseasechronic obstructive pulmonary disease

TTC23 CRIM1 NEBL TLE1

3.84e-03688284EFO_0000341
Diseaseconotruncal heart malformations

NEBL NUP210

5.24e-03114282MONDO_0016581
Diseaseneuroblastoma

CRIM1 RPTN

5.42e-03116282EFO_0000621
Diseasespine bone mineral density

SPP1 TLE1

5.69e-03119282EFO_0007701
Diseasesmoking behavior, BMI-adjusted waist circumference

NSD1 ADAMTS3

5.97e-03122282EFO_0004318, EFO_0007789
DiseaseBMI-adjusted waist circumference, physical activity measurement

NSD1 ADAMTS3

6.07e-03123282EFO_0007789, EFO_0008002
DiseaseMammary Neoplasms, Experimental

SPP1 SCD

9.48e-03155282C0024668

Protein segments in the cluster

PeptideGeneStartEntry
VDFGSATFDHEHHST

CLK2

326

P49760
VADFGSATFDHEHHT

CLK3

466

P49761
HLTSEDGDHFSDVHF

NSD1

1096

Q96L73
REFHSHEFHSHEDML

SPP1

271

P10451
VHFHDNSGDVFHAHS

NUP210

1406

Q8TEM1
VEAHGHGVTHDHEDS

GABRQ

486

Q9UN88
ADHHSKHEAQRHFLE

KIAA1109

1086

Q2LD37
DHGELGSHHCQDHSD

POU3F4

171

P49335
RSDLNHSEHHDHAIF

ADAMTS3

341

O15072
VDGHHHKNEESWHDG

CRIM1

611

Q9NZV1
HDAEGSHSHVHFDEK

C20orf27

21

Q9GZN8
SHSHVHFDEKLHDSV

C20orf27

26

Q9GZN8
GHGHSHGHESNKFLE

SLC39A10

476

Q9ULF5
DHSHSDGLHTIHEHD

SLC39A10

606

Q9ULF5
DGLHTIHEHDLHAAA

SLC39A10

611

Q9ULF5
AAEKSVVHEHEHSHD

SLC39A9

86

Q9NUM3
HGAHKHHPIEEAAEE

TRIM43

121

Q96BQ3
DTEDSAEHRHHLPSH

HRC

141

P23327
SEEDEDVSDGHHHHG

HRC

221

P23327
HGIEEDEDVSDGHHH

HRC

276

P23327
DEDVSDGHHHRDPSH

HRC

281

P23327
DTLGQSDDLIHHHHD

SLC39A6

546

Q13433
HSLAGDEATHHTEDA

BRPF1

751

P55201
DDKKHHDAEHHRDRE

TLE1

181

Q04724
EDEEHTTEHTPNHHV

UNC80

1821

Q8N2C7
TFHDSKHNIVHVHFD

WDFY2

361

Q96P53
HDDLHDDLQEDFHGH

SLC39A7

31

Q92504
DDLQEDFHGHSHRHS

SLC39A7

36

Q92504
IDVEFHDTSIHHATH

WDHD1

466

O75717
LEDVFHFADHQETHH

ZNF587

101

Q96SQ5
LEDVFHFADHQETHH

ZNF417

101

Q8TAU3
HEKNSHHIHKNADDS

WAPL

176

Q7Z5K2
DHRAHHKFSETHADP

SCD

156

O00767
DGHDVDDPHSFHQSK

IK

16

Q13123
AHAAVASGRHEHHDV

TTC23

276

Q5W5X9
SHHGQSEKQDRDSHH

RPTN

156

Q6XPR3
FADDTDPHVHHSTHL

ZNF285

241

Q96NJ3
HFVGCHHSRDSEHTE

LYPD6B

116

Q8NI32
HFDADAVEHLHHKGN

NEBL

316

O76041